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MCID: BNC003
MIFTS: 61

Bone Cancer

Categories: Bone diseases, Cancer diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Bone Cancer

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MalaCards integrated aliases for Bone Cancer:

Name: Bone Cancer 12 44 15
Malignant Bone Neoplasm 12 17 74
Bone Carcinoma 12 15 74
Bone Neoplasms 77 45 74
Bone Neoplasm 12 17
Malignant Neoplasm of Bone 12
Malignant Osseous Tumor 12
Malignant Bone Tumour 12
Osteosarcoma of Bone 74
Osteogenic Neoplasm 74
Ca - Bone Cancer 12
Neoplasm of Bone 12
Osseous Tumor 12
Bone Tumour 12

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Bone Cancer

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MedlinePlus : 44 Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another part of the body is more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and 19. It is more common in the knee and upper arm. Chondrosarcoma - starts in cartilage, usually after age 40 Ewing's sarcoma - occurs most often in children and teens under 19. It is more common in boys than girls. The most common symptom of bone cancer is pain. Other symptoms vary, depending on the location and size of the cancer. Surgery is often the main treatment for bone cancer. Other treatments may include amputation, chemotherapy, and radiation therapy. Because bone cancer can come back after treatment, regular follow-up visits are important. NIH: National Cancer Institute

MalaCards based summary : Bone Cancer, also known as malignant bone neoplasm, is related to ewing sarcoma and villonodular synovitis, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Bone Cancer is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Pathways in cancer and TNFR1 Pathway. The drugs Prednisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and breast, and related phenotypes are behavior/neurological and growth/size/body region

Disease Ontology : 12 A connective tissue cancer that is located in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.

Wikipedia : 77 A bone tumor is a neoplastic growth of tissue in bone. Abnormal growths found in the bone can be either... more...

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Related Diseases for Bone Cancer

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Diseases in the Bone Cancer family:

Primary Bone Cancer

Diseases related to Bone Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 165)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 31.4 BMI1 CDKN2A CYCS EWSR1 IL6 MMP9
2 villonodular synovitis 30.0 MMP9 TNFSF11
3 pain agnosia 30.0 CNR1 PDYN TRPV1
4 giant cell tumor 29.9 MMP9 TNFRSF11A TNFSF11
5 bone resorption disease 29.7 ESR1 IL6 TNFRSF11A TNFSF11 TRPV1
6 chest wall bone cancer 12.2
7 primary bone cancer 12.1
8 bone marrow cancer 11.3
9 maxillary cancer 11.0
10 adamantinoma of long bones 10.9
11 osteogenic sarcoma 10.9
12 aneurysmal bone cysts 10.9
13 bone squamous cell carcinoma 10.9
14 chondrosarcoma 10.8
15 multiple enchondromatosis, maffucci type 10.8
16 bone fracture 10.8
17 long bones of lower limb cancer 10.8
18 jaw cancer 10.8
19 orbital cancer 10.8
20 bone giant cell tumor 10.8
21 sternum cancer 10.8
22 paget's disease of bone 10.8
23 femoral cancer 10.8
24 bone lymphoma 10.8
25 polyarticular onset juvenile idiopathic arthritis 10.5 TNFRSF11A TNFSF11
26 cyclic vomiting syndrome 10.5 CNR1 IL6
27 hemophilic arthropathy 10.5 TNFRSF11A TNFSF11
28 osteoporotic fracture 10.5 ESR1 IL6
29 osteopetrosis, autosomal recessive 7 10.4 TNFRSF11A TNFSF11
30 agnosia 10.4 CNR1 PDYN TRPV1
31 breast leiomyosarcoma 10.4 TNFRSF11A TNFSF11
32 specific developmental disorder 10.4 CNR1 PDYN TRPV1
33 paget disease of bone 5, juvenile-onset 10.4 TNFRSF11A TNFSF11
34 periapical periodontitis 10.4 IL6 TNFRSF11A TNFSF11
35 periodontitis, chronic 10.4 IL6 TNFSF11
36 root resorption 10.4 P2RX7 TNFRSF11A TNFSF11
37 dissociative amnesia 10.4 PDYN TNFSF11
38 autoimmune disease of central nervous system 10.4 CCL2 IL6 TRPV1
39 mouth disease 10.4 IL6 TNFSF11 TRPV1
40 bartholin's gland benign neoplasm 10.4 CDKN2A ESR1
41 hallucinogen dependence 10.4 CNR1 PENK
42 connective tissue cancer 10.4 EWSR1 TNFSF11 TRPV1
43 drug dependence 10.4 CNR1 PDYN PENK
44 adenomyosis 10.4 ESR1 MMP9 TRPV1
45 cystitis 10.4 CCL2 IL6 TRPV1
46 rosacea 10.4 IL6 MMP9 TRPV1
47 urinary system disease 10.3 CCL2 IL6 TRPV1
48 bone remodeling disease 10.3 ESR1 TNFRSF11A TNFSF11 TRPV1
49 acquired metabolic disease 10.3 CCL2 IL6 TRPV1
50 disease of mental health 10.3 CNR1 IL6 PDYN TRPV1

Graphical network of the top 20 diseases related to Bone Cancer:



Diseases related to Bone Cancer
Sources

Symptoms & Phenotypes for Bone Cancer

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UMLS symptoms related to Bone Cancer:


back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Bone Cancer:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.32 ATF3 CDKN2A CNR1 CYCS ESR1 IL6
2 growth/size/body region MP:0005378 10.27 ATF3 CDKN2A CNR1 CYCS ESR1 IL6
3 homeostasis/metabolism MP:0005376 10.18 ATF3 CDKN2A CNR1 ESR1 IL6 MMP9
4 immune system MP:0005387 10.18 ATF3 CCL2 CDKN2A CYCS ESR1 IL6
5 hematopoietic system MP:0005397 10.13 ATF3 CDKN2A CYCS ESR1 IL6 MMP9
6 cardiovascular system MP:0005385 10.1 CDKN2A CYCS ESR1 IL6 MMP9 MTAP
7 integument MP:0010771 10.1 ATF3 CDKN2A CNR1 ESR1 IL6 MMP9
8 digestive/alimentary MP:0005381 10.02 CDKN2A CNR1 ESR1 IL6 MMP9 PDYN
9 adipose tissue MP:0005375 10 ATF3 CNR1 ESR1 IL6 PDYN TRPV1
10 neoplasm MP:0002006 9.86 ATF3 CDKN2A ESR1 IL6 MMP9 TNFRSF11A
11 no phenotypic analysis MP:0003012 9.81 ATF3 CDKN2A CNR1 ESR1 PDYN PENK
12 respiratory system MP:0005388 9.56 ATF3 CDKN2A ESR1 IL6 MMP9 MTAP
13 skeleton MP:0005390 9.32 CDKN2A CNR1 CYCS ESR1 IL6 MMP9
Sources

Drugs & Therapeutics for Bone Cancer

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Drugs for Bone Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 485)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 1 53-03-2 5865
2
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
4
Dopamine Approved Phase 4,Phase 2 62-31-7, 51-61-6 681
5
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
6
Zoledronic Acid Approved Phase 4,Phase 2,Phase 3,Phase 1 118072-93-8 68740
7
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1 615258-40-7
8
Radium Ra 223 dichloride Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 444811-40-9
9
Lithium carbonate Approved Phase 4 554-13-2
10
Dalteparin Approved Phase 4,Not Applicable 9005-49-6
11
Heparin Approved, Investigational Phase 4,Not Applicable 9005-49-6 772 46507594
12
Enoxaparin Approved Phase 4 9005-49-6 772
13
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
14
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
15
Calcium Approved, Nutraceutical Phase 4,Phase 1,Phase 2,Not Applicable 7440-70-2 271
16
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 1406-16-2
17 Hydrocortisone 17-butyrate 21-propionate Phase 4
18 Hydrocortisone-17-butyrate Phase 4
19 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
21 Anesthetics Phase 4,Phase 3,Phase 1,Not Applicable
22 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Hydrocortisone hemisuccinate Phase 4
25 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
26 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
27 Central Nervous System Stimulants Phase 4,Phase 3,Phase 2,Phase 1
28 Adrenergic Agents Phase 4,Not Applicable
29 Dopamine Uptake Inhibitors Phase 4
30 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
31 Sympathomimetics Phase 4
32 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Neurotransmitter Uptake Inhibitors Phase 4
34 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
35 Dopamine Agents Phase 4,Phase 2
36 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
37 Diphosphonates Phase 4,Phase 2,Phase 3,Early Phase 1
38 Vitamins Phase 4,Phase 1,Phase 2,Not Applicable
39 Calcium, Dietary Phase 4,Phase 1,Phase 2,Not Applicable
40 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
41 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
42 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
43 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
44 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Ibandronic Acid Phase 4,Phase 3,Phase 2
46 Calciferol Phase 4,Phase 2,Phase 1
47 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Early Phase 1,Not Applicable
48 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
49 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
50 Immunoglobulin G Phase 4,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 785)
# Name Status NCT ID Phase Drugs
1 The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy Unknown status NCT02905916 Phase 4 PEG-rhG-CSF
2 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
3 Bioactive Glass Granules in Filling of Bone Defects Completed NCT01304121 Phase 4
4 Long Term Efficacy and Safety of Zoledronic Acid Treatment in Patients With Bone Metastases Completed NCT00434447 Phase 4 Zoledronic acid
5 A Study to Assess the Short Term Efficacy of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Pain Due to Breast Cancer Completed NCT02553707 Phase 4 Ibandronate
6 A Study of Ibandronate (Bondronat) in Participants With Metastatic Bone Disease Completed NCT02564107 Phase 4 Ibandronate
7 FREE Study - Fracture Reduction Evaluation Completed NCT00211211 Phase 4
8 Effect of Zoledronic Acid as Anti-Cancer Treatment in Metastatic Breast Cancer Patients Completed NCT01129336 Phase 4 Zoledronic acid;Standard Therapy
9 Screening Non Small Cell Lung Cancer With Bone Metastasis and Efficacy and Safety Research of Receiving Bisphosphonates Completed NCT00765687 Phase 4 bisphosphates
10 Efficacy and Safety Study of ZOMETA® in Treatment of High-level NTX Non Small Cell Lung Cancer With Bone Metastasis Completed NCT00762346 Phase 4 zometa
11 Assessment of the Efficacy, Tolerability and Pharmaco-economic Impact of Zoledronic Acid Treatment in Prostate Cancer With Bone Metastasis Completed NCT00241111 Phase 4 zoledronic acid
12 Effect of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastasis Completed NCT00237159 Phase 4 Zoledronic acid
13 Effect of Zoledronic Acid on Bone Metabolism in Patients With Bone Metastasis and Prostate or Breast Cancer Completed NCT00334139 Phase 4 Zoledronic Acid
14 Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma Recruiting NCT01669369 Phase 4 Lithium Carbonate;Placebo
15 Radium-223 Dichloride Long-term Follow-up Program Recruiting NCT02312960 Phase 4
16 Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004 Active, not recruiting NCT03301857 Phase 4 Denosumab (Cohort A)
17 Low Molecular Weight Heparin (LMWH) vs Aspirin for Venous Thromboembolism (VTE) Prophylaxis in Orthopaedic Oncology Enrolling by invitation NCT03244020 Phase 4 Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
18 Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer Not yet recruiting NCT02480634 Phase 4 Zoledronic acid
19 A Study To Evaluate Pregabalin In The Treatment Of Moderate To Severe Chronic Bone Pain Related To Metastatic Cancer Terminated NCT00381095 Phase 4 Pregabalin;Placebo
20 Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma Unknown status NCT00691236 Phase 2, Phase 3 Zoledronic acid;Standard chemotherapy
21 A Clinical Trial on Efficacy and Safety for Lobaplatin and Gemcitabine in Combination With Docetaxel in the Second-line Treatments on Advanced Osteosarcoma Unknown status NCT02099396 Phase 2, Phase 3 Docetaxel+lobaplatin;Gemcitabine+lobaplatin
22 Laser Therapy Prevents Mucositis Oral in Chemotherapy for Bone Marrow Transplantation? Unknown status NCT02020928 Phase 3
23 Non-invasive Focal Therapy for Osteoid Osteoma Unknown status NCT02302651 Phase 2, Phase 3
24 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Unknown status NCT01987596 Phase 3
25 Biological Image Guided Antalgic Stereotactic Body Radiotherapy of Bone Metastases Unknown status NCT01429493 Phase 2, Phase 3
26 F18PET/CT Versus TC-MDP Scanning to Detect Bone Mets Unknown status NCT00882609 Phase 3
27 Study in Localized and Disseminated Ewing Sarcoma Unknown status NCT00987636 Phase 3 Zoledronic acid;Busulfan;Treosulfan
28 Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
29 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
30 Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement Unknown status NCT01813240 Phase 2, Phase 3 Minocycline;placebo
31 SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Unknown status NCT00517959 Phase 3
32 Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy Completed NCT02711007 Phase 2, Phase 3 apatinib
33 Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children Completed NCT00180908 Phase 3 Etoposide, Ifosfamide, Methotrexate;Doxorubicin, Methotrexate
34 Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma Completed NCT01176981 Phase 3 High Dose Methotrexate
35 Osteosarcoma Study #2: A Randomized Trial of Pre-Surgical Chemotherapy vs. Immediate Surgery and Adjuvant Chemotherapy in the Treatment of Non-Metastatic Osteosarcoma. A Pediatric Oncology Group Phase III Study Completed NCT00001217 Phase 3 pre-surgical chemotherapy
36 Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma Completed NCT00002539 Phase 3 cisplatin;doxorubicin hydrochloride
37 Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Completed NCT00003937 Phase 3 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate
38 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
39 A Study to Evaluate Renal Safety of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Disease Due to Breast Cancer Completed NCT02716792 Phase 3 Ibandronate
40 A Study of Ibandronate (Bondronat) in Participants With Malignant Bone Disease Completed NCT02561039 Phase 3 Ibandronate
41 Recombinant Human Keratinocyte Growth Factor to Reduce Oral Mucositis in Hematologic Malignancy Patients Undergoing Peripheral Blood Stem Cell Transplantation After Radiation and High-dose Chemotherapy Completed NCT00041665 Phase 3 Recombinant Human Keratinocyte Growth Factor
42 Ridaforolimus in Treatment of Sarcoma-SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus)(8669-011 AM6) Completed NCT00538239 Phase 3 ridaforolimus;Placebo
43 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
44 Dexamethasone for Pain Flare After Radiotherapy of Painful Bone metastasesZonMW 11510009 Completed NCT01669499 Phase 3 Dexamethasone acetate;Placebo
45 Palliation: the Effect of Education on Pain Completed NCT01358539 Phase 3
46 Dexamethasone vs Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases Completed NCT01248585 Phase 3 Dexamethasone;Placebo
47 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
48 Evaluation of Vertebroplasty Associated With Radiotherapy for Spine Metastases (EVAR) Completed NCT00267033 Phase 3
49 Palliative Radiotherapy for Bone Metastases: Single Versus Multiple Fractions. Completed NCT00858741 Phase 3
50 Optimization of Radiotherapy in Treatment of Painful Bone Metastasis Completed NCT00610272 Phase 3

Search NIH Clinical Center for Bone Cancer

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: bone neoplasms

Sources

Genetic Tests for Bone Cancer

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Sources

Anatomical Context for Bone Cancer

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MalaCards organs/tissues related to Bone Cancer:

42
Bone, Prostate, Breast, Lung, Brain, T Cells, Spinal Cord

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Cancer:

20
Bone
Sources

Publications for Bone Cancer

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Articles related to Bone Cancer:

(show top 50) (show all 487)
# Title Authors Year
1
Pain: Persistent postsurgery and bone cancer-related pain. ( 30632434 )
2019
2
Imbalanced spinal infiltration of Th17/Treg cells contributes to bone cancer pain via promoting microglial activation. ( 30685532 )
2019
3
Brain and Bone Cancer Targeting by a Ferrofluid Composed of Superparamagnetic Iron-Oxide/Silica/Carbon Nanoparticles, (Earthicles). ( 30711662 )
2019
4
Neuroinflammation and central PI3K/Akt/mTOR signal pathway contribute to bone cancer pain. ( 30717619 )
2019
5
Biological and toxicological evaluation of N-(4methyl-phenyl)-4-methylphthalimide on bone cancer in mice. ( 30734686 )
2019
6
Upregulation of bone morphogenetic protein 2 ( Bmp2) in dorsal root ganglion in a rat model of bone cancer pain. ( 30799697 )
2019
7
Thalidomide alleviates bone cancer pain by down-regulating expressions of NF-κB and GFAP in spinal astrocytes in a mouse model. ( 30806135 )
2019
8
Comparative evaluation of magnetic hyperthermia performance and biocompatibility of magnetite and novel Fe-doped hardystonite nanoparticles for potential bone cancer therapy. ( 30813100 )
2019
9
The roles of chemokine CXCL13 in the development of bone cancer pain and the regulation of morphine analgesia in rats. ( 30826523 )
2019
10
Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus. ( 30829675 )
2019
11
Growing Without Pain: The Noninvasive Expandable Prosthesis is Boon for Children with Bone Cancer, as well as Their Surgeons! ( 30905999 )
2019
12
The short interference RNA (siRNA) targeting NMUR2 relieves nociception in a bone cancer pain model of rat through PKC-ERK and PI3K-AKT pathways. ( 30914203 )
2019
13
Suppression of HDAC2 in Spinal Cord Alleviates Mechanical Hyperalgesia and Restores KCC2 Expression in a Rat Model of Bone Cancer Pain. ( 29482000 )
2018
14
Adverse events associated with aprepitant pediatric bone cancer patients. ( 29409391 )
2018
15
A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain Without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain. ( 29371114 )
2018
16
Socio-economic patterning in early mortality of patients aged 0-49 years diagnosed with primary bone cancer in Great Britain, 1985-2008. ( 29414632 )
2018
17
IL-18 Contributes to Bone Cancer Pain by Regulating Glia Cells and Neuron Interaction. ( 29079540 )
2018
18
Longitudinal resting-state fMRI in a mouse model of metastatic bone cancer reveals distinct functional reorganizations along a developing chronic pain state. ( 29319607 )
2018
19
Expression of BDNF in dorsal root ganglion of rats with bone cancer pain and its effect on pain behavior. ( 29504577 )
2018
20
Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice. ( 29867362 )
2018
21
Spinal PKC activation - Induced neuronal HMGB1 translocation contributes to hyperalgesia in a bone cancer pain model in rats. ( 29428215 )
2018
22
CORR InsightsAr: Can Augmented Reality Be Helpful in Pelvic Bone Cancer Surgery? An In Vitro Study. ( 29762155 )
2018
23
Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment. ( 29127069 )
2018
24
Hedgehog signaling contributes to bone cancer pain by regulating sensory neuron excitability in rats. ( 29607715 )
2018
25
Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer. ( 29357732 )
2018
26
Electrical peripheral nerve stimulation relieves bone cancer pain by inducing Arc protein expression in the spinal cord dorsal horn. ( 29606887 )
2018
27
Neuronal complement cascade drives bone cancer pain via C3R mediated microglial activation. ( 29909203 )
2018
28
Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype. ( 29882480 )
2018
29
<sup>18</sup>F-Fluoride PET/CT and <sup>99m</sup>Tc-MDP SPECT/CT can detect bone cancer at early stage in rodents. ( 29778807 )
2018
30
Preconditioning with hydrogen sulfide prevents bone cancer pain in rats through a proliferator-activated receptor gamma/p38/Jun N-terminal kinase pathway. ( 29096563 )
2018
31
Blockage of spinal endothelin A receptors attenuates bone cancer pain via regulation of the Akt/ERK signaling pathway in mice. ( 29395120 )
2018
32
Health professional perceptions of communicating with adolescents and young adults about bone cancer clinical trial participation. ( 29978324 )
2018
33
A new method for selecting auricle positions in skull base reconstruction for temporal bone cancer. ( 29574745 )
2018
34
Fluoridation and county-level secondary bone cancer among cancer patients 18 years or older in New York State. ( 30109528 )
2018
35
Activation of the P2X7 receptor in midbrain periaqueductal gray participates in the analgesic effect of tramadol in bone cancer pain rats. ( 30198382 )
2018
36
Bone Cancer: Diagnosis and Treatment Principles. ( 30215968 )
2018
37
Bone Cancer. ( 30215985 )
2018
38
Bone morphogenetic protein and activin membrane-bound inhibitor suppress bone cancer progression in MG63 and SAOS cells via regulation of the TGF-β-induced EMT signaling pathway. ( 30250579 )
2018
39
In vitro evaluation of a biomaterial-based anticancer drug delivery system as an alternative to conventional post-surgery bone cancer treatment. ( 30274043 )
2018
40
Iodine-125 seed implantation combined with arterial chemoembolization therapy for pain palliation in metastatic bone cancer: a retrospective study. ( 30296196 )
2018
41
Bone-Cancer Assessment and Destruction Pattern Analysis in Long-Bone X-ray Image. ( 30367308 )
2018
42
Decitabine attenuates nociceptive behavior in a murine model of bone cancer pain. ( 30422869 )
2018
43
SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission. ( 30579931 )
2018
44
The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat. ( 30592048 )
2018
45
Can Augmented Reality Be Helpful in Pelvic Bone Cancer Surgery? An In Vitro Study. ( 30794209 )
2018
46
Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats. ( 29196874 )
2017
47
STAT1 as a downstream mediator of ERK signaling contributes to bone cancer pain by regulating MHC II expression in spinal microglia. ( 27742579 )
2017
48
Teniposide ameliorates bone cancer nociception in rats via the P2X7 receptor. ( 28825192 )
2017
49
Effect of alkylaminophenols on growth inhibition and apoptosis of bone cancer cells. ( 28728976 )
2017
50
Normalizing GDNF expression in the spinal cord alleviates cutaneous hyperalgesia but not ongoing pain in a rat model of bone cancer pain. ( 27716965 )
2017
Sources

Variations for Bone Cancer

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Copy number variations for Bone Cancer from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 70082 12 58138784 58142025 Amplification SAS Bone cancer
2 70083 12 58141509 58146230 Amplification CDK4 Bone cancer
3 71134 12 67700000 68661632 Amplification MDM2 Bone cancer
Sources

Expression for Bone Cancer

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Search GEO for disease gene expression data for Bone Cancer.
Sources

Pathways for Bone Cancer

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Pathways related to Bone Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 38
12.58 CDKN2A CYCS ESR1 IL6 MMP9
2
TNFR1 Pathway 65
Show member pathways
 12.28 ATF3 CCL2 CYCS IL6 MMP9 TNFRSF11A
3
Transcriptional misregulation in cancer 38
11.94 BMI1 EWSR1 IL6 MMP9
4
TNF signaling pathway 38
11.73 CCL2 IL6 MMP9
5
Senescence and Autophagy in Cancer 1
11.7 BMI1 CDKN2A IL6
6
Spinal Cord Injury 1
11.54 CCL2 IL6 MMP9 PDYN
7
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.46 CCL2 IL6 MMP9
8
Lung fibrosis 1
11.38 CCL2 IL6 MMP9
9
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.15 IL6 TNFRSF11A TNFSF11
10
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
10.96 CCL2 IL6 MMP9
11
Rheumatoid arthritis 38
10.88 CCL2 IL6 TNFRSF11A TNFSF11
12
Osteoclast Signaling 1
10.68 TNFRSF11A TNFSF11
Sources

GO Terms for Bone Cancer

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Biological processes related to Bone Cancer according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.88 CCL2 IL6 PDYN PENK RLN2 TNFSF11
2 cytokine-mediated signaling pathway GO:0019221 9.86 CCL2 IL6 MMP9 TNFSF11
3 positive regulation of gene expression GO:0010628 9.85 ATF3 CDKN2A IL6 P2RX7 RLN2 TNFSF11
4 response to lipopolysaccharide GO:0032496 9.81 CNR1 P2RX7 PENK TNFRSF11A
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 IL6 TNFRSF11A TNFSF11 TRIM14
6 response to bacterium GO:0009617 9.74 CCL2 P2RX7 PENK
7 positive regulation of apoptotic process GO:0043065 9.73 CDKN2A CNR1 IL6 MMP9 P2RX7 TRPV1
8 ossification GO:0001503 9.72 MMP9 TNFRSF11A TNFSF11
9 negative regulation of bone resorption GO:0045779 9.54 IL6 P2RX7
10 PERK-mediated unfolded protein response GO:0036499 9.52 ATF3 CCL2
11 mammary gland alveolus development GO:0060749 9.5 ESR1 TNFRSF11A TNFSF11
12 TNFSF11-mediated signaling pathway GO:0071847 9.48 TNFRSF11A TNFSF11
13 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.46 TNFRSF11A TNFSF11
14 sensory perception of pain GO:0019233 9.46 CNR1 P2RX7 PENK TRPV1
15 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.43 TNFRSF11A TNFSF11
16 monocyte chemotaxis GO:0002548 9.26 CCL2 IL6 TNFRSF11A TNFSF11
17 positive regulation of DNA-binding transcription factor activity GO:0051091 9.02 ESR1 IL6 TNFRSF11A TNFSF11 TRIM14

Molecular functions related to Bone Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 opioid peptide activity GO:0001515 8.62 PDYN PENK
Sources

Sources for Bone Cancer

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The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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