Bone Cancer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BNC003 MIFTS: 62	Bone Cancer Categories: Bone diseases, Cancer diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Bone Cancer

MalaCards integrated aliases for Bone Cancer:

Name: Bone Cancer ¹² ⁴⁴ ¹⁵

Malignant Bone Neoplasm ¹² ¹⁷ ⁷⁴

Bone Carcinoma ¹² ¹⁵ ⁷⁴

Bone Neoplasms ⁷⁷ ⁴⁵ ⁷⁴

Bone Neoplasm ¹² ¹⁷

Malignant Neoplasm of Bone ¹²

Malignant Osseous Tumor ¹²

Malignant Bone Tumour ¹²

Osteosarcoma of Bone ⁷⁴

Osteogenic Neoplasm ⁷⁴

Ca - Bone Cancer ¹²

Neoplasm of Bone ¹²

Osseous Tumor ¹²

Bone Tumour ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:184 DOID:2762

MeSH ⁴⁵ D001859

NCIt ⁵¹ C36082 C9343

EFO ¹⁷ EFO_0003820 EFO_1000350

UMLS ⁷⁴ C0005967 C0279530 C0585442 more

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Summaries for Bone Cancer

MedlinePlus : ⁴⁴ Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another part of the body is more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and 19. It is more common in the knee and upper arm. Chondrosarcoma - starts in cartilage, usually after age 40 Ewing's sarcoma - occurs most often in children and teens under 19. It is more common in boys than girls. The most common symptom of bone cancer is pain. Other symptoms vary, depending on the location and size of the cancer. Surgery is often the main treatment for bone cancer. Other treatments may include amputation, chemotherapy, and radiation therapy. Because bone cancer can come back after treatment, regular follow-up visits are important. NIH: National Cancer Institute

MalaCards based summary : Bone Cancer, also known as malignant bone neoplasm, is related to ewing sarcoma and pain agnosia, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Bone Cancer is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Pathways in cancer and TNFR1 Pathway. The drugs Prednisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and breast, and related phenotypes are behavior/neurological and growth/size/body region

Disease Ontology : ¹² A connective tissue cancer that is located in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.

Wikipedia : ⁷⁷ A bone tumor is a neoplastic growth of tissue in bone. Abnormal growths found in the bone can be either... more...

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Related Diseases for Bone Cancer

Diseases in the Bone Cancer family:

Primary Bone Cancer

Diseases related to Bone Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)

#	Related Disease	Score	Top Affiliating Genes
1	ewing sarcoma	31.5	BMI1 CYCS EWSR1 IL6 MMP9
2	pain agnosia	30.2	CNR1 PDYN TRPV1
3	villonodular synovitis	30.0	MMP9 TNFSF11
4	giant cell tumor	29.9	MMP9 TNFRSF11A TNFSF11
5	bone inflammation disease	29.9	CCL2 IL6 TNFSF11 TRPV1
6	osteoporosis	29.6	BMP2 ESR1 IL6 TNFRSF11A TNFSF11
7	bone resorption disease	29.5	BMP2 ESR1 IL6 TNFRSF11A TNFSF11 TRPV1
8	rheumatoid arthritis	29.4	CCL2 IL6 MMP9 TNFRSF11A TNFSF11
9	chest wall bone cancer	12.2
10	primary bone cancer	12.2
11	bone marrow cancer	11.3
12	osteogenic sarcoma	11.3
13	maxillary cancer	11.0
14	adamantinoma of long bones	10.9
15	aneurysmal bone cysts	10.9
16	bone squamous cell carcinoma	10.9
17	chondrosarcoma	10.8
18	multiple enchondromatosis, maffucci type	10.8
19	bone fracture	10.8
20	long bones of lower limb cancer	10.8
21	jaw cancer	10.8
22	orbital cancer	10.8
23	bone giant cell tumor	10.8
24	sternum cancer	10.8
25	femoral cancer	10.8
26	bone lymphoma	10.8
27	polyarticular onset juvenile idiopathic arthritis	10.5	TNFRSF11A TNFSF11
28	cyclic vomiting syndrome	10.5	CNR1 IL6
29	tooth ankylosis	10.5	BMP2 TNFSF11
30	osteoporotic fracture	10.4	ESR1 IL6
31	hemophilic arthropathy	10.4	TNFRSF11A TNFSF11
32	agnosia	10.4	CNR1 PDYN TRPV1
33	osteopetrosis, autosomal recessive 7	10.4	TNFRSF11A TNFSF11
34	breast leiomyosarcoma	10.4	TNFRSF11A TNFSF11
35	specific developmental disorder	10.4	CNR1 PDYN TRPV1
36	paget disease of bone 5, juvenile-onset	10.4	TNFRSF11A TNFSF11
37	periodontitis, chronic	10.4	IL6 TNFSF11
38	tooth resorption	10.4	BMP2 TNFRSF11A TNFSF11
39	ischemic bone disease	10.4	BMP2 TNFRSF11A TNFSF11
40	periapical periodontitis	10.4	IL6 TNFRSF11A TNFSF11
41	osteomyelitis	10.4	BMP2 IL6 TNFSF11
42	mouth disease	10.4	IL6 TNFSF11 TRPV1
43	root resorption	10.4	P2RX7 TNFRSF11A TNFSF11
44	dissociative amnesia	10.4	PDYN TNFSF11
45	autoimmune disease of central nervous system	10.4	CCL2 IL6 TRPV1
46	drug dependence	10.4	CNR1 PDYN PENK
47	hallucinogen dependence	10.4	CNR1 PENK
48	connective tissue cancer	10.4	EWSR1 TNFSF11 TRPV1
49	cystitis	10.4	CCL2 IL6 TRPV1
50	adenomyosis	10.3	ESR1 MMP9 TRPV1

Graphical network of the top 20 diseases related to Bone Cancer:

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Symptoms & Phenotypes for Bone Cancer

UMLS symptoms related to Bone Cancer:

back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Bone Cancer:

⁴⁷ (show all 14)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	10.3	ATF3 CNR1 CYCS ESR1 IL6 MMP9
2	growth/size/body region	MP:0005378	10.29	ATF3 BMP2 CNR1 CYCS ESR1 IL6
3	immune system	MP:0005387	10.22	ATF3 BMP2 CCL2 CYCS ESR1 IL6
4	homeostasis/metabolism	MP:0005376	10.21	ATF3 BMP2 CNR1 ESR1 IL6 MMP9
5	hematopoietic system	MP:0005397	10.16	ATF3 BMP2 CYCS ESR1 IL6 MMP9
6	cardiovascular system	MP:0005385	10.11	BMP2 CYCS ESR1 IL6 MMP9 MTAP
7	integument	MP:0010771	10.11	ATF3 CNR1 ESR1 IL6 MMP9 P2RX7
8	digestive/alimentary	MP:0005381	10.04	BMP2 CNR1 ESR1 IL6 MMP9 PDYN
9	adipose tissue	MP:0005375	10.01	ATF3 CNR1 ESR1 IL6 PDYN TRPV1
10	limbs/digits/tail	MP:0005371	9.8	BMP2 ESR1 MMP9 P2RX7 TNFRSF11A TNFSF11
11	neoplasm	MP:0002006	9.8	ATF3 ESR1 IL6 MMP9 TNFRSF11A TNFSF11
12	no phenotypic analysis	MP:0003012	9.76	ATF3 CNR1 ESR1 PDYN PENK TNFRSF11A
13	respiratory system	MP:0005388	9.5	ATF3 ESR1 IL6 MMP9 MTAP TNFRSF11A
14	skeleton	MP:0005390	9.32	BMP2 CNR1 CYCS ESR1 IL6 MMP9

Sources

Drugs & Therapeutics for Bone Cancer

Drugs for Bone Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 492)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Prednisone

Approved, Vet_approved

Phase 4,Phase 2,Phase 1

53-03-2

5865

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

5754

Methamphetamine

Approved, Illicit

Phase 4

537-46-2

10836

Dopamine

Approved

Phase 4,Phase 2

62-31-7, 51-61-6

681

Zoledronic Acid

Approved

Phase 4,Phase 2,Phase 3,Phase 1

118072-93-8

68740

Denosumab

Approved

Phase 4,Phase 3,Phase 2,Phase 1

615258-40-7

Radium Ra 223 dichloride

Approved, Investigational

Phase 4,Phase 3,Phase 1,Phase 2

444811-40-9

Lithium carbonate

Approved

Phase 4

554-13-2

Heparin

Approved, Investigational

Phase 4,Not Applicable

9005-49-6

46507594 772

Dalteparin

Approved

Phase 4,Not Applicable

9005-49-6

Enoxaparin

Approved

Phase 4

9005-49-6

772

Aspirin

Approved, Vet_approved

Phase 4

50-78-2

2244

Pregabalin

Approved, Illicit, Investigational

Phase 4

148553-50-8

5486971

Calcium

Approved, Nutraceutical

Phase 4,Phase 1,Phase 2,Not Applicable

7440-70-2

271

Vitamin D

Approved, Nutraceutical, Vet_approved

Phase 4,Phase 2,Phase 1

1406-16-2

Antineoplastic Agents, Hormonal

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hydrocortisone-17-butyrate

Phase 4

Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Anesthetics

Phase 4,Phase 3,Phase 1,Not Applicable

Hydrocortisone 17-butyrate 21-propionate

Phase 4

glucocorticoids

Phase 4,Phase 3,Phase 2,Phase 1

Anti-Inflammatory Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Hydrocortisone hemisuccinate

Phase 4

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1

Hormones

Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1

Central Nervous System Stimulants

Phase 4,Phase 3,Phase 2,Phase 1

Dopamine Uptake Inhibitors

Phase 4

Peripheral Nervous System Agents

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable

Adrenergic Agents

Phase 4,Not Applicable

Sympathomimetics

Phase 4

Dopamine Agents

Phase 4,Phase 2

Neurotransmitter Agents

Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable

Autonomic Agents

Phase 4,Phase 3,Phase 2,Phase 1

Neurotransmitter Uptake Inhibitors

Phase 4

Bone Density Conservation Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Diphosphonates

Phase 4,Phase 2,Phase 3,Early Phase 1

Calcium, Dietary

Phase 4,Phase 1,Phase 2,Not Applicable

Vitamins

Phase 4,Phase 1,Phase 2,Not Applicable

Antibodies

Phase 4,Phase 3,Phase 2,Phase 1

Immunoglobulins

Phase 4,Phase 3,Phase 2,Phase 1

Immunologic Factors

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Antibodies, Monoclonal

Phase 4,Phase 3,Phase 2,Phase 1

Analgesics, Non-Narcotic

Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable

Analgesics

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Anti-Inflammatory Agents, Non-Steroidal

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Antirheumatic Agents

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1

Ibandronic Acid

Phase 4,Phase 3,Phase 2

Calciferol

Phase 4,Phase 2,Phase 1

Central Nervous System Depressants

Phase 4,Phase 3,Phase 1,Early Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 793)

#	Name	Status	NCT ID	Phase	Drugs
1	The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy	Unknown status	NCT02905916	Phase 4	PEG-rhG-CSF
2	Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions	Unknown status	NCT02190994	Phase 4	Hydrocortisone;Prednisone
3	Bioactive Glass Granules in Filling of Bone Defects	Completed	NCT01304121	Phase 4
4	Long Term Efficacy and Safety of Zoledronic Acid Treatment in Patients With Bone Metastases	Completed	NCT00434447	Phase 4	Zoledronic acid
5	A Study to Assess the Short Term Efficacy of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Pain Due to Breast Cancer	Completed	NCT02553707	Phase 4	Ibandronate
6	A Study of Ibandronate (Bondronat) in Participants With Metastatic Bone Disease	Completed	NCT02564107	Phase 4	Ibandronate
7	FREE Study - Fracture Reduction Evaluation	Completed	NCT00211211	Phase 4
8	Effect of Zoledronic Acid as Anti-Cancer Treatment in Metastatic Breast Cancer Patients	Completed	NCT01129336	Phase 4	Zoledronic acid;Standard Therapy
9	Screening Non Small Cell Lung Cancer With Bone Metastasis and Efficacy and Safety Research of Receiving Bisphosphonates	Completed	NCT00765687	Phase 4	bisphosphates
10	Efficacy and Safety Study of ZOMETA® in Treatment of High-level NTX Non Small Cell Lung Cancer With Bone Metastasis	Completed	NCT00762346	Phase 4	zometa
11	Assessment of the Efficacy, Tolerability and Pharmaco-economic Impact of Zoledronic Acid Treatment in Prostate Cancer With Bone Metastasis	Completed	NCT00241111	Phase 4	zoledronic acid
12	Effect of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastasis	Completed	NCT00237159	Phase 4	Zoledronic acid
13	Effect of Zoledronic Acid on Bone Metabolism in Patients With Bone Metastasis and Prostate or Breast Cancer	Completed	NCT00334139	Phase 4	Zoledronic Acid
14	Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma	Recruiting	NCT01669369	Phase 4	Lithium Carbonate;Placebo
15	Zoledronic Acid in Decrease the Lung Metastatic Rate of Osteosarcoma	Recruiting	NCT03932071	Phase 4	Zoledronic Acid
16	Radium-223 Dichloride Long-term Follow-up Program	Recruiting	NCT02312960	Phase 4
17	Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004	Active, not recruiting	NCT03301857	Phase 4	Denosumab (Cohort A)
18	Low Molecular Weight Heparin (LMWH) vs Aspirin for Venous Thromboembolism (VTE) Prophylaxis in Orthopaedic Oncology	Enrolling by invitation	NCT03244020	Phase 4	Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
19	Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer	Not yet recruiting	NCT02480634	Phase 4	Zoledronic acid
20	A Study To Evaluate Pregabalin In The Treatment Of Moderate To Severe Chronic Bone Pain Related To Metastatic Cancer	Terminated	NCT00381095	Phase 4	Pregabalin;Placebo
21	Characteristics and Mechanism of Denosumab-treated Giant Cell Tumor of Bone	Unknown status	NCT03259152	Phase 3	Denosumab
22	Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma	Unknown status	NCT00691236	Phase 2, Phase 3	Zoledronic acid;Standard chemotherapy
23	A Clinical Trial on Efficacy and Safety for Lobaplatin and Gemcitabine in Combination With Docetaxel in the Second-line Treatments on Advanced Osteosarcoma	Unknown status	NCT02099396	Phase 2, Phase 3	Docetaxel+lobaplatin;Gemcitabine+lobaplatin
24	Laser Therapy Prevents Mucositis Oral in Chemotherapy for Bone Marrow Transplantation?	Unknown status	NCT02020928	Phase 3
25	Non-invasive Focal Therapy for Osteoid Osteoma	Unknown status	NCT02302651	Phase 2, Phase 3
26	Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer	Unknown status	NCT01987596	Phase 3
27	Biological Image Guided Antalgic Stereotactic Body Radiotherapy of Bone Metastases	Unknown status	NCT01429493	Phase 2, Phase 3
28	F18PET/CT Versus TC-MDP Scanning to Detect Bone Mets	Unknown status	NCT00882609	Phase 3
29	Study in Localized and Disseminated Ewing Sarcoma	Unknown status	NCT00987636	Phase 3	Zoledronic acid;Busulfan;Treosulfan
30	Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma	Unknown status	NCT00002516	Phase 3	cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
31	Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma	Unknown status	NCT00020566	Phase 3	busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
32	Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement	Unknown status	NCT01813240	Phase 2, Phase 3	Minocycline;placebo
33	SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors	Unknown status	NCT00517959	Phase 3
34	ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma	Completed	NCT01459484	Phase 2, Phase 3	Mifamurtide arm
35	Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy	Completed	NCT02711007	Phase 2, Phase 3	apatinib
36	Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children	Completed	NCT00180908	Phase 3	Etoposide, Ifosfamide, Methotrexate;Doxorubicin, Methotrexate
37	Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma	Completed	NCT01176981	Phase 3	High Dose Methotrexate
38	Osteosarcoma Study #2: A Randomized Trial of Pre-Surgical Chemotherapy vs. Immediate Surgery and Adjuvant Chemotherapy in the Treatment of Non-Metastatic Osteosarcoma. A Pediatric Oncology Group Phase III Study	Completed	NCT00001217	Phase 3	pre-surgical chemotherapy
39	Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma	Completed	NCT00002539	Phase 3	cisplatin;doxorubicin hydrochloride
40	Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma	Completed	NCT00003937	Phase 3	cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate
41	Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy	Completed	NCT00716976	Phase 3	sodium thiosulfate
42	A Study to Evaluate Renal Safety of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Disease Due to Breast Cancer	Completed	NCT02716792	Phase 3	Ibandronate
43	A Study of Ibandronate (Bondronat) in Participants With Malignant Bone Disease	Completed	NCT02561039	Phase 3	Ibandronate
44	Recombinant Human Keratinocyte Growth Factor to Reduce Oral Mucositis in Hematologic Malignancy Patients Undergoing Peripheral Blood Stem Cell Transplantation After Radiation and High-dose Chemotherapy	Completed	NCT00041665	Phase 3	Recombinant Human Keratinocyte Growth Factor
45	Ridaforolimus in Treatment of Sarcoma-SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus)(8669-011 AM6)	Completed	NCT00538239	Phase 3	ridaforolimus;Placebo
46	Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma	Completed	NCT00346164	Phase 3	doxorubicin hydrochloride;ifosfamide
47	Dexamethasone for Pain Flare After Radiotherapy of Painful Bone metastasesZonMW 11510009	Completed	NCT01669499	Phase 3	Dexamethasone acetate;Placebo
48	Palliation: the Effect of Education on Pain	Completed	NCT01358539	Phase 3
49	Dexamethasone vs Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases	Completed	NCT01248585	Phase 3	Dexamethasone;Placebo
50	Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain	Completed	NCT00538850	Phase 3	Fentanyl sublingual spray;Placebo

Search NIH Clinical Center for Bone Cancer

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :

zoledronic

zoledronic acid

Cochrane evidence based reviews: bone neoplasms

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Genetic Tests for Bone Cancer

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Anatomical Context for Bone Cancer

MalaCards organs/tissues related to Bone Cancer:

⁴²

Bone, Prostate, Breast, Lung, Brain, T Cells, Spinal Cord

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Cancer:

²⁰

Bone

Sources

Publications for Bone Cancer

Articles related to Bone Cancer:

(show top 50) (show all 490)

#	Title	Authors	Year
1	Adverse events associated with aprepitant pediatric bone cancer patients. ( 29409391 )	Okumura LM...Moreira LB	2019
2	Health professional perceptions of communicating with adolescents and young adults about bone cancer clinical trial participation. ( 29978324 )	Lavender V...Pearce S	2019
3	Fluoridation and county-level secondary bone cancer among cancer patients 18 years or older in New York State. ( 30109528 )	Crnosija N...Meliker JR	2019
4	Bone-Cancer Assessment and Destruction Pattern Analysis in Long-Bone X-ray Image. ( 30367308 )	Bandyopadhyay O...Bhattacharya BB	2019
5	Decitabine attenuates nociceptive behavior in a murine model of bone cancer pain. ( 30422869 )	Appel CK...Heegaard AM	2019
6	Pain: Persistent postsurgery and bone cancer-related pain. ( 30632434 )	Feller L...Lemmer J	2019
7	Imbalanced spinal infiltration of Th17/Treg cells contributes to bone cancer pain via promoting microglial activation. ( 30685532 )	Huo W...Gu X	2019
8	Brain and bone cancer targeting by a ferrofluid composed of superparamagnetic iron-oxide/silica/carbon nanoparticles (earthicles). ( 30711662 )	Wu VM...Uskokovi? V	2019
9	Neuroinflammation and central PI3K/Akt/mTOR signal pathway contribute to bone cancer pain. ( 30717619 )	Zhang J...Pang X	2019
10	Biological and toxicological evaluation of N-(4methyl-phenyl)-4-methylphthalimide on bone cancer in mice. ( 30734686 )	Santin JR...Quint?o NLM	2019
11	Upregulation of bone morphogenetic protein 2 ( Bmp2) in dorsal root ganglion in a rat model of bone cancer pain. ( 30799697 )	Wang W...Xu M	2019
12	Thalidomide alleviates bone cancer pain by down-regulating expressions of NF-κB and GFAP in spinal astrocytes in a mouse model. ( 30806135 )	Tian J...Yan R	2019
13	Comparative evaluation of magnetic hyperthermia performance and biocompatibility of magnetite and novel Fe-doped hardystonite nanoparticles for potential bone cancer therapy. ( 30813100 )	Farzin A...Ai J	2019
14	The roles of chemokine CXCL13 in the development of bone cancer pain and the regulation of morphine analgesia in rats. ( 30826523 )	Bu HL...Zhang W	2019
15	Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus. ( 30829675 )	Dai J...Song Z	2019
16	Growing Without Pain: The Noninvasive Expandable Prosthesis is Boon for Children with Bone Cancer, as well as Their Surgeons! ( 30905999 )	Gundavda MK...Agarwal MG	2019
17	The short interference RNA (siRNA) targeting NMUR2 relieves nociception in a bone cancer pain model of rat through PKC-ERK and PI3K-AKT pathways. ( 30914203 )	Peng S...Wang J	2019
18	XPro1595 ameliorates bone cancer pain in rats via inhibiting p38-mediated glial cell activation and neuroinflammation in the spinal dorsal horn. ( 31002915 )	Zhou KX...Dong YL	2019
19	Suppression of WNK1-SPAK/OSR1 attenuates bone cancer pain by regulating NKCC1 and KCC2. ( 31085334 )	Gao JL...Yang JP	2019
20	Incidence and mortality of bone cancer among children, adolescents and young adults of Brazil. ( 31090796 )	Balmant NV...Camargo B	2019
21	Analgesic effects of microRNA-129-5p against bone cancer pain through the EphB1/EphrinB2 signaling pathway in mice. ( 29236320 )	Yu SN...Li XF	2019
22	Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain. ( 29300279 )	Remeniuk B...Porreca F	2018
23	Longitudinal resting-state functional magnetic resonance imaging in a mouse model of metastatic bone cancer reveals distinct functional reorganizations along a developing chronic pain state. ( 29319607 )	Buehlmann D...Rudin M	2018
24	Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer. ( 29357732 )	Watanabe M...Narita M	2018
25	A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain Without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain. ( 29371114 )	Edwards KA...Streicher JM	2018
26	Blockage of spinal endothelin A receptors attenuates bone cancer pain via regulation of the Akt/ERK signaling pathway in mice. ( 29395120 )	Han MM...Li J	2018
27	Socio-economic patterning in early mortality of patients aged 0-49 years diagnosed with primary bone cancer in Great Britain, 1985-2008. ( 29414632 )	Blakey K...McNally RJQ	2018
28	Spinal PKC activation - Induced neuronal HMGB1 translocation contributes to hyperalgesia in a bone cancer pain model in rats. ( 29428215 )	An K...Yao M	2018
29	Suppression of HDAC2 in Spinal Cord Alleviates Mechanical Hyperalgesia and Restores KCC2 Expression in a Rat Model of Bone Cancer Pain. ( 29482000 )	Hou X...Guo Q	2018
30	Expression of BDNF in dorsal root ganglion of rats with bone cancer pain and its effect on pain behavior. ( 29504577 )	Huang Y	2018
31	A new method for selecting auricle positions in skull base reconstruction for temporal bone cancer. ( 29574745 )	Tanaka K...Okazaki M	2018
32	Electrical peripheral nerve stimulation relieves bone cancer pain by inducing Arc protein expression in the spinal cord dorsal horn. ( 29606887 )	Sun KF...Yang HL	2018
33	Hedgehog signaling contributes to bone cancer pain by regulating sensory neuron excitability in rats. ( 29607715 )	Liu S...Liu GJ	2018
34	CORR Insights®: Can Augmented Reality Be Helpful in Pelvic Bone Cancer Surgery? An In Vitro Study. ( 29762155 )	Gerrand C	2018
35	18F-Fluoride PET/CT and 99mTc-MDP SPECT/CT can detect bone cancer at early stage in rodents. ( 29778807 )	Alves CRR...Brum PC	2018
36	Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice. ( 29867362 )	Yang H...Wu L	2018
37	Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype. ( 29882480 )	Huo W...Gu X	2018
38	Neuronal complement cascade drives bone cancer pain via C3R mediated microglial activation. ( 29909203 )	Huang X...Ke C	2018
39	Activation of the P2X7 receptor in midbrain periaqueductal gray participates in the analgesic effect of tramadol in bone cancer pain rats. ( 30198382 )	Li P...Qin Y	2018
40	Bone Cancer: Diagnosis and Treatment Principles. ( 30215968 )	Ferguson JL...Turner SP	2018
41	Bone Cancer. ( 30215985 )		2018
42	Bone morphogenetic protein and activin membrane-bound inhibitor suppress bone cancer progression in MG63 and SAOS cells via regulation of the TGF-β-induced EMT signaling pathway. ( 30250579 )	Liu F...Yang YL	2018
43	In vitro evaluation of a biomaterial-based anticancer drug delivery system as an alternative to conventional post-surgery bone cancer treatment. ( 30274043 )	Bischoff I...Unger RE	2018
44	Iodine-125 seed implantation combined with arterial chemoembolization therapy for pain palliation in metastatic bone cancer: a retrospective study. ( 30296196 )	Yang Z...Jin L	2018
45	SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission. ( 30579931 )	Li MY...Zhu HL	2018
46	The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat. ( 30592048 )	Lux S...Constandil L	2018
47	Can Augmented Reality Be Helpful in Pelvic Bone Cancer Surgery? An In Vitro Study. ( 30794209 )	Cho HS...Hong J	2018
48	The perceptions of teenagers, young adults and professionals in the participation of bone cancer clinical trials. ( 26936110 )	Pearce S...Lavender V	2018
49	Hyperthermia effect and antibacterial efficacy of Fe3+ /Co2+ co-substitutions in β-Ca3 (PO4 )2 for bone cancer and defect therapy. ( 28661574 )	Singh RK...Kannan S	2018
50	Teniposide ameliorates bone cancer nociception in rats via the P2X7 receptor. ( 28825192 )	Yan J...Zeng Z	2018

Sources

Genes for Bone Cancer

Genes related to Bone Cancer (0 elite genes):

(show all 27)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	21.65	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	TNFSF11	TNF Superfamily Member 11	Protein Coding	21.58	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	BMP2	Bone Morphogenetic Protein 2	Protein Coding	20.6	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	MTAP	Methylthioadenosine Phosphorylase	Protein Coding	20.19	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	IL6	Interleukin 6	Protein Coding	20.16	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
6	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	20.14	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	CYCS	Cytochrome C, Somatic	Protein Coding	20.04	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	P2RX7	Purinergic Receptor P2X 7	Protein Coding	19.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	PDYN	Prodynorphin	Protein Coding	19.78	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	EWSR1	EWS RNA Binding Protein 1	Protein Coding	19.74	DISEASES inferred ¹⁵
11	MRC2	Mannose Receptor C Type 2	Protein Coding	19.56	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	CNR1	Cannabinoid Receptor 1	Protein Coding	19.54	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	ESR1	Estrogen Receptor 1	Protein Coding	19.51	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	MMP9	Matrix Metallopeptidase 9	Protein Coding	19.38	DISEASES inferred ¹⁵ ¹⁵
15	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	19.33	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	PENK	Proenkephalin	Protein Coding	19.21	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
17	BMI1	BMI1 Proto-Oncogene, Polycomb Ring Finger	Protein Coding	19.05	DISEASES inferred ¹⁵ ¹⁵
18	ATF3	Activating Transcription Factor 3	Protein Coding	19.01	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
19	TRIM14	Tripartite Motif Containing 14	Protein Coding	10.18	DISEASES inferred ¹⁵ ¹⁵
20	RLN2	Relaxin 2	Protein Coding	9.68	DISEASES inferred ¹⁵ ¹⁵
21	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	8.57	DISEASES inferred ¹⁵ ¹⁵
22	ENG	Endoglin	Protein Coding	8.13	DISEASES inferred ¹⁵ ¹⁵
23	TRAT1	T Cell Receptor Associated Transmembrane Adaptor 1	Protein Coding	7.88	DISEASES inferred ¹⁵ ¹⁵
24	RECK	Reversion Inducing Cysteine Rich Protein With Kazal Motifs	Protein Coding	7.63	DISEASES inferred ¹⁵ ¹⁵
25	CD99	CD99 Molecule (Xg Blood Group)	Protein Coding	7.4	DISEASES inferred ¹⁵
26	CLUAP1	Clusterin Associated Protein 1	Protein Coding	7.13	GeneCards inferred via : Proteins (show sections)
27	CDK1	Cyclin Dependent Kinase 1	Protein Coding	7.12	DISEASES inferred ¹⁵ ¹⁵

Sources

Variations for Bone Cancer

Copy number variations for Bone Cancer from CNVD:

⁷

#	CNVD ID	Chromosom	Start	End	Type	Gene Symbol	CNVD Disease
1	70082	12	58138784	58142025	Amplification	SAS	Bone cancer
2	70083	12	58141509	58146230	Amplification	CDK4	Bone cancer
3	71134	12	67700000	68661632	Amplification	MDM2	Bone cancer

Sources

Expression for Bone Cancer

Search GEO for disease gene expression data for Bone Cancer.

Sources

Pathways for Bone Cancer

Pathways related to Bone Cancer according to GeneCards Suite gene sharing:

(show all 14)

#	Super pathways	Score	Top Affiliating Genes
1	Pathways in cancer ³⁸	12.6	BMP2 CYCS ESR1 IL6 MMP9
2	TNFR1 Pathway ⁶⁵ Show member pathways Apoptosis and survival TNFR1 signaling pathway ²³ Apoptosis through Death Receptors ⁶⁵ Apoptotic Pathways Triggered By HIV1 ⁶⁵ DR3 Signaling ⁶⁵ Fas Signaling ⁶⁵ GITR Pathway ⁶⁵ HIV-1 Nef- Negative effector of Fas and TNF-alpha ¹ Stimulation of the cell death response by PAK-2p34 ⁶⁷ TNF alpha Signaling Pathway ¹ TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway ¹ TNF Signaling ⁶⁵ TRAIL Pathway ⁶⁵ TWEAK Pathway ⁶⁵	12.28	ATF3 CCL2 CYCS IL6 MMP9 TNFRSF11A
3	Transcriptional misregulation in cancer ³⁸	11.94	BMI1 EWSR1 IL6 MMP9
4	TNF signaling pathway ³⁸	11.75	CCL2 IL6 MMP9
5	Senescence and Autophagy in Cancer ¹	11.73	BMI1 BMP2 IL6
6	Spinal Cord Injury ¹	11.54	CCL2 IL6 MMP9 PDYN
7	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁶	11.48	CCL2 IL6 MMP9
8	Lung fibrosis ¹	11.41	CCL2 IL6 MMP9
9	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	11.15	IL6 TNFRSF11A TNFSF11
10	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ¹	10.96	CCL2 IL6 MMP9
11	G-protein signaling_RhoB regulation pathway ²³	10.94	BMP2 CCL2 IL6 TNFSF11
12	Rheumatoid arthritis ³⁸	10.88	CCL2 IL6 TNFRSF11A TNFSF11
13	G-protein signaling_Rap2B regulation pathway ²³	10.8	BMP2 CCL2 IL6 PENK TNFSF11
14	Osteoclast Signaling ¹	10.71	TNFRSF11A TNFSF11

Sources

GO Terms for Bone Cancer

Biological processes related to Bone Cancer according to GeneCards Suite gene sharing:

(show all 21)

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	9.95	BMP2 CCL2 IL6 P2RX7 TRPV1
2	cytokine-mediated signaling pathway	GO:0019221	9.89	CCL2 IL6 MMP9 TNFSF11
3	positive regulation of gene expression	GO:0010628	9.88	ATF3 BMP2 IL6 P2RX7 RLN2 TNFSF11
4	response to lipopolysaccharide	GO:0032496	9.84	CNR1 P2RX7 PENK TNFRSF11A
5	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.83	IL6 TNFRSF11A TNFSF11 TRIM14
6	response to bacterium	GO:0009617	9.8	BMP2 CCL2 P2RX7 PENK
7	positive regulation of apoptotic process	GO:0043065	9.8	BMP2 CNR1 IL6 MMP9 P2RX7 TRPV1
8	osteoblast differentiation	GO:0001649	9.77	BMP2 MRC2 PENK
9	cellular response to organic cyclic compound	GO:0071407	9.73	BMP2 CCL2 P2RX7
10	ossification	GO:0001503	9.73	BMP2 MMP9 TNFRSF11A TNFSF11
11	positive regulation of ossification	GO:0045778	9.58	BMP2 P2RX7
12	negative regulation of bone resorption	GO:0045779	9.58	IL6 P2RX7
13	PERK-mediated unfolded protein response	GO:0036499	9.57	ATF3 CCL2
14	sensory perception of pain	GO:0019233	9.56	CNR1 P2RX7 PENK TRPV1
15	mammary gland alveolus development	GO:0060749	9.54	ESR1 TNFRSF11A TNFSF11
16	TNFSF11-mediated signaling pathway	GO:0071847	9.51	TNFRSF11A TNFSF11
17	regulation of signaling receptor activity	GO:0010469	9.5	BMP2 CCL2 IL6 PDYN PENK RLN2
18	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	GO:0071848	9.48	TNFRSF11A TNFSF11
19	positive regulation of fever generation by positive regulation of prostaglandin secretion	GO:0071812	9.46	TNFRSF11A TNFSF11
20	monocyte chemotaxis	GO:0002548	9.46	CCL2 IL6 TNFRSF11A TNFSF11
21	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.02	ESR1 IL6 TNFRSF11A TNFSF11 TRIM14

Molecular functions related to Bone Cancer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.26	BMP2 CCL2 IL6 TNFSF11
2	opioid peptide activity	GO:0001515	8.62	PDYN PENK

Sources

Sources for Bone Cancer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia

Bone Cancer

Aliases & Classifications for Bone Cancer

MalaCards integrated aliases for Bone Cancer:

Classifications:

External Ids:

Summaries for Bone Cancer

Related Diseases for Bone Cancer

Diseases in the Bone Cancer family:

Diseases related to Bone Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Bone Cancer:

Symptoms & Phenotypes for Bone Cancer

UMLS symptoms related to Bone Cancer:

MGI Mouse Phenotypes related to Bone Cancer:

Drugs & Therapeutics for Bone Cancer

Drugs for Bone Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

Interventional clinical trials:

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: bone neoplasms

Genetic Tests for Bone Cancer

Anatomical Context for Bone Cancer

MalaCards organs/tissues related to Bone Cancer:

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Cancer:

Publications for Bone Cancer

Articles related to Bone Cancer:

Genes for Bone Cancer

Genes related to Bone Cancer (0 elite genes):

Variations for Bone Cancer

Copy number variations for Bone Cancer from CNVD:

Expression for Bone Cancer

Pathways for Bone Cancer

Pathways related to Bone Cancer according to GeneCards Suite gene sharing:

GO Terms for Bone Cancer

Biological processes related to Bone Cancer according to GeneCards Suite gene sharing:

Molecular functions related to Bone Cancer according to GeneCards Suite gene sharing:

Sources for Bone Cancer

Inferred drug relations via UMLS ⁷⁴ / NDF-RT ⁵² :