Bone Cancer

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Bone Cancer

MalaCards integrated aliases for Bone Cancer:

Name: Bone Cancer 12 44 15
Malignant Bone Neoplasm 12 17 74
Bone Carcinoma 12 15 74
Bone Neoplasms 77 45 74
Bone Neoplasm 12 17
Malignant Neoplasm of Bone 12
Malignant Osseous Tumor 12
Malignant Bone Tumour 12
Osteosarcoma of Bone 74
Osteogenic Neoplasm 74
Ca - Bone Cancer 12
Neoplasm of Bone 12
Osseous Tumor 12
Bone Tumour 12


Summaries for Bone Cancer

MedlinePlus : 44 Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another part of the body is more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and 19. It is more common in the knee and upper arm. Chondrosarcoma - starts in cartilage, usually after age 40 Ewing's sarcoma - occurs most often in children and teens under 19. It is more common in boys than girls. The most common symptom of bone cancer is pain. Other symptoms vary, depending on the location and size of the cancer. Surgery is often the main treatment for bone cancer. Other treatments may include amputation, chemotherapy, and radiation therapy. Because bone cancer can come back after treatment, regular follow-up visits are important. NIH: National Cancer Institute

MalaCards based summary : Bone Cancer, also known as malignant bone neoplasm, is related to ewing sarcoma and pain agnosia, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Bone Cancer is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Pathways in cancer and TNFR1 Pathway. The drugs Prednisone and Hydrocortisone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and breast, and related phenotypes are behavior/neurological and growth/size/body region

Disease Ontology : 12 A connective tissue cancer that is located in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.

Wikipedia : 77 A bone tumor is a neoplastic growth of tissue in bone. Abnormal growths found in the bone can be either... more...

Related Diseases for Bone Cancer

Diseases in the Bone Cancer family:

Primary Bone Cancer

Diseases related to Bone Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 167)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 31.5 BMI1 CYCS EWSR1 IL6 MMP9
2 pain agnosia 30.2 CNR1 PDYN TRPV1
3 villonodular synovitis 30.0 MMP9 TNFSF11
4 giant cell tumor 29.9 MMP9 TNFRSF11A TNFSF11
5 bone inflammation disease 29.9 CCL2 IL6 TNFSF11 TRPV1
6 osteoporosis 29.6 BMP2 ESR1 IL6 TNFRSF11A TNFSF11
7 bone resorption disease 29.5 BMP2 ESR1 IL6 TNFRSF11A TNFSF11 TRPV1
8 rheumatoid arthritis 29.4 CCL2 IL6 MMP9 TNFRSF11A TNFSF11
9 chest wall bone cancer 12.2
10 primary bone cancer 12.2
11 bone marrow cancer 11.3
12 osteogenic sarcoma 11.3
13 maxillary cancer 11.0
14 adamantinoma of long bones 10.9
15 aneurysmal bone cysts 10.9
16 bone squamous cell carcinoma 10.9
17 chondrosarcoma 10.8
18 multiple enchondromatosis, maffucci type 10.8
19 bone fracture 10.8
20 long bones of lower limb cancer 10.8
21 jaw cancer 10.8
22 orbital cancer 10.8
23 bone giant cell tumor 10.8
24 sternum cancer 10.8
25 femoral cancer 10.8
26 bone lymphoma 10.8
27 polyarticular onset juvenile idiopathic arthritis 10.5 TNFRSF11A TNFSF11
28 cyclic vomiting syndrome 10.5 CNR1 IL6
29 tooth ankylosis 10.5 BMP2 TNFSF11
30 osteoporotic fracture 10.4 ESR1 IL6
31 hemophilic arthropathy 10.4 TNFRSF11A TNFSF11
32 agnosia 10.4 CNR1 PDYN TRPV1
33 osteopetrosis, autosomal recessive 7 10.4 TNFRSF11A TNFSF11
34 breast leiomyosarcoma 10.4 TNFRSF11A TNFSF11
35 specific developmental disorder 10.4 CNR1 PDYN TRPV1
36 paget disease of bone 5, juvenile-onset 10.4 TNFRSF11A TNFSF11
37 periodontitis, chronic 10.4 IL6 TNFSF11
38 tooth resorption 10.4 BMP2 TNFRSF11A TNFSF11
39 ischemic bone disease 10.4 BMP2 TNFRSF11A TNFSF11
40 periapical periodontitis 10.4 IL6 TNFRSF11A TNFSF11
41 osteomyelitis 10.4 BMP2 IL6 TNFSF11
42 mouth disease 10.4 IL6 TNFSF11 TRPV1
43 root resorption 10.4 P2RX7 TNFRSF11A TNFSF11
44 dissociative amnesia 10.4 PDYN TNFSF11
45 autoimmune disease of central nervous system 10.4 CCL2 IL6 TRPV1
46 drug dependence 10.4 CNR1 PDYN PENK
47 hallucinogen dependence 10.4 CNR1 PENK
48 connective tissue cancer 10.4 EWSR1 TNFSF11 TRPV1
49 cystitis 10.4 CCL2 IL6 TRPV1
50 adenomyosis 10.3 ESR1 MMP9 TRPV1

Graphical network of the top 20 diseases related to Bone Cancer:

Diseases related to Bone Cancer

Symptoms & Phenotypes for Bone Cancer

UMLS symptoms related to Bone Cancer:

back pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Bone Cancer:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.3 ATF3 CNR1 CYCS ESR1 IL6 MMP9
2 growth/size/body region MP:0005378 10.29 ATF3 BMP2 CNR1 CYCS ESR1 IL6
3 immune system MP:0005387 10.22 ATF3 BMP2 CCL2 CYCS ESR1 IL6
4 homeostasis/metabolism MP:0005376 10.21 ATF3 BMP2 CNR1 ESR1 IL6 MMP9
5 hematopoietic system MP:0005397 10.16 ATF3 BMP2 CYCS ESR1 IL6 MMP9
6 cardiovascular system MP:0005385 10.11 BMP2 CYCS ESR1 IL6 MMP9 MTAP
7 integument MP:0010771 10.11 ATF3 CNR1 ESR1 IL6 MMP9 P2RX7
8 digestive/alimentary MP:0005381 10.04 BMP2 CNR1 ESR1 IL6 MMP9 PDYN
9 adipose tissue MP:0005375 10.01 ATF3 CNR1 ESR1 IL6 PDYN TRPV1
10 limbs/digits/tail MP:0005371 9.8 BMP2 ESR1 MMP9 P2RX7 TNFRSF11A TNFSF11
11 neoplasm MP:0002006 9.8 ATF3 ESR1 IL6 MMP9 TNFRSF11A TNFSF11
12 no phenotypic analysis MP:0003012 9.76 ATF3 CNR1 ESR1 PDYN PENK TNFRSF11A
13 respiratory system MP:0005388 9.5 ATF3 ESR1 IL6 MMP9 MTAP TNFRSF11A
14 skeleton MP:0005390 9.32 BMP2 CNR1 CYCS ESR1 IL6 MMP9

Drugs & Therapeutics for Bone Cancer

Drugs for Bone Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 492)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 1 53-03-2 5865
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
Dopamine Approved Phase 4,Phase 2 62-31-7, 51-61-6 681
Zoledronic Acid Approved Phase 4,Phase 2,Phase 3,Phase 1 118072-93-8 68740
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1 615258-40-7
Radium Ra 223 dichloride Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 444811-40-9
Lithium carbonate Approved Phase 4 554-13-2
Heparin Approved, Investigational Phase 4,Not Applicable 9005-49-6 46507594 772
Dalteparin Approved Phase 4,Not Applicable 9005-49-6
Enoxaparin Approved Phase 4 9005-49-6 772
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
Calcium Approved, Nutraceutical Phase 4,Phase 1,Phase 2,Not Applicable 7440-70-2 271
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 1406-16-2
17 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Hydrocortisone-17-butyrate Phase 4
19 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
20 Anesthetics Phase 4,Phase 3,Phase 1,Not Applicable
21 Hydrocortisone 17-butyrate 21-propionate Phase 4
22 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
23 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Hydrocortisone hemisuccinate Phase 4
25 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Hormones Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1
27 Central Nervous System Stimulants Phase 4,Phase 3,Phase 2,Phase 1
28 Dopamine Uptake Inhibitors Phase 4
29 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
30 Adrenergic Agents Phase 4,Not Applicable
31 Sympathomimetics Phase 4
32 Dopamine Agents Phase 4,Phase 2
33 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable
34 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
35 Neurotransmitter Uptake Inhibitors Phase 4
36 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Diphosphonates Phase 4,Phase 2,Phase 3,Early Phase 1
38 Calcium, Dietary Phase 4,Phase 1,Phase 2,Not Applicable
39 Vitamins Phase 4,Phase 1,Phase 2,Not Applicable
40 Antibodies Phase 4,Phase 3,Phase 2,Phase 1
41 Immunoglobulins Phase 4,Phase 3,Phase 2,Phase 1
42 Immunologic Factors Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
43 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2,Phase 1
44 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
45 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
46 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
47 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
48 Ibandronic Acid Phase 4,Phase 3,Phase 2
49 Calciferol Phase 4,Phase 2,Phase 1
50 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Early Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 793)
# Name Status NCT ID Phase Drugs
1 The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy Unknown status NCT02905916 Phase 4 PEG-rhG-CSF
2 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
3 Bioactive Glass Granules in Filling of Bone Defects Completed NCT01304121 Phase 4
4 Long Term Efficacy and Safety of Zoledronic Acid Treatment in Patients With Bone Metastases Completed NCT00434447 Phase 4 Zoledronic acid
5 A Study to Assess the Short Term Efficacy of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Pain Due to Breast Cancer Completed NCT02553707 Phase 4 Ibandronate
6 A Study of Ibandronate (Bondronat) in Participants With Metastatic Bone Disease Completed NCT02564107 Phase 4 Ibandronate
7 FREE Study - Fracture Reduction Evaluation Completed NCT00211211 Phase 4
8 Effect of Zoledronic Acid as Anti-Cancer Treatment in Metastatic Breast Cancer Patients Completed NCT01129336 Phase 4 Zoledronic acid;Standard Therapy
9 Screening Non Small Cell Lung Cancer With Bone Metastasis and Efficacy and Safety Research of Receiving Bisphosphonates Completed NCT00765687 Phase 4 bisphosphates
10 Efficacy and Safety Study of ZOMETA® in Treatment of High-level NTX Non Small Cell Lung Cancer With Bone Metastasis Completed NCT00762346 Phase 4 zometa
11 Assessment of the Efficacy, Tolerability and Pharmaco-economic Impact of Zoledronic Acid Treatment in Prostate Cancer With Bone Metastasis Completed NCT00241111 Phase 4 zoledronic acid
12 Effect of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastasis Completed NCT00237159 Phase 4 Zoledronic acid
13 Effect of Zoledronic Acid on Bone Metabolism in Patients With Bone Metastasis and Prostate or Breast Cancer Completed NCT00334139 Phase 4 Zoledronic Acid
14 Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma Recruiting NCT01669369 Phase 4 Lithium Carbonate;Placebo
15 Zoledronic Acid in Decrease the Lung Metastatic Rate of Osteosarcoma Recruiting NCT03932071 Phase 4 Zoledronic Acid
16 Radium-223 Dichloride Long-term Follow-up Program Recruiting NCT02312960 Phase 4
17 Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004 Active, not recruiting NCT03301857 Phase 4 Denosumab (Cohort A)
18 Low Molecular Weight Heparin (LMWH) vs Aspirin for Venous Thromboembolism (VTE) Prophylaxis in Orthopaedic Oncology Enrolling by invitation NCT03244020 Phase 4 Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
19 Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer Not yet recruiting NCT02480634 Phase 4 Zoledronic acid
20 A Study To Evaluate Pregabalin In The Treatment Of Moderate To Severe Chronic Bone Pain Related To Metastatic Cancer Terminated NCT00381095 Phase 4 Pregabalin;Placebo
21 Characteristics and Mechanism of Denosumab-treated Giant Cell Tumor of Bone Unknown status NCT03259152 Phase 3 Denosumab
22 Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma Unknown status NCT00691236 Phase 2, Phase 3 Zoledronic acid;Standard chemotherapy
23 A Clinical Trial on Efficacy and Safety for Lobaplatin and Gemcitabine in Combination With Docetaxel in the Second-line Treatments on Advanced Osteosarcoma Unknown status NCT02099396 Phase 2, Phase 3 Docetaxel+lobaplatin;Gemcitabine+lobaplatin
24 Laser Therapy Prevents Mucositis Oral in Chemotherapy for Bone Marrow Transplantation? Unknown status NCT02020928 Phase 3
25 Non-invasive Focal Therapy for Osteoid Osteoma Unknown status NCT02302651 Phase 2, Phase 3
26 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Unknown status NCT01987596 Phase 3
27 Biological Image Guided Antalgic Stereotactic Body Radiotherapy of Bone Metastases Unknown status NCT01429493 Phase 2, Phase 3
28 F18PET/CT Versus TC-MDP Scanning to Detect Bone Mets Unknown status NCT00882609 Phase 3
29 Study in Localized and Disseminated Ewing Sarcoma Unknown status NCT00987636 Phase 3 Zoledronic acid;Busulfan;Treosulfan
30 Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
31 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
32 Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement Unknown status NCT01813240 Phase 2, Phase 3 Minocycline;placebo
33 SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Unknown status NCT00517959 Phase 3
34 ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma Completed NCT01459484 Phase 2, Phase 3 Mifamurtide arm
35 Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy Completed NCT02711007 Phase 2, Phase 3 apatinib
36 Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children Completed NCT00180908 Phase 3 Etoposide, Ifosfamide, Methotrexate;Doxorubicin, Methotrexate
37 Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma Completed NCT01176981 Phase 3 High Dose Methotrexate
38 Osteosarcoma Study #2: A Randomized Trial of Pre-Surgical Chemotherapy vs. Immediate Surgery and Adjuvant Chemotherapy in the Treatment of Non-Metastatic Osteosarcoma. A Pediatric Oncology Group Phase III Study Completed NCT00001217 Phase 3 pre-surgical chemotherapy
39 Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma Completed NCT00002539 Phase 3 cisplatin;doxorubicin hydrochloride
40 Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Completed NCT00003937 Phase 3 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate
41 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
42 A Study to Evaluate Renal Safety of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Disease Due to Breast Cancer Completed NCT02716792 Phase 3 Ibandronate
43 A Study of Ibandronate (Bondronat) in Participants With Malignant Bone Disease Completed NCT02561039 Phase 3 Ibandronate
44 Recombinant Human Keratinocyte Growth Factor to Reduce Oral Mucositis in Hematologic Malignancy Patients Undergoing Peripheral Blood Stem Cell Transplantation After Radiation and High-dose Chemotherapy Completed NCT00041665 Phase 3 Recombinant Human Keratinocyte Growth Factor
45 Ridaforolimus in Treatment of Sarcoma-SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus)(8669-011 AM6) Completed NCT00538239 Phase 3 ridaforolimus;Placebo
46 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
47 Dexamethasone for Pain Flare After Radiotherapy of Painful Bone metastasesZonMW 11510009 Completed NCT01669499 Phase 3 Dexamethasone acetate;Placebo
48 Palliation: the Effect of Education on Pain Completed NCT01358539 Phase 3
49 Dexamethasone vs Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases Completed NCT01248585 Phase 3 Dexamethasone;Placebo
50 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo

Search NIH Clinical Center for Bone Cancer

Inferred drug relations via UMLS 74 / NDF-RT 52 :

Cochrane evidence based reviews: bone neoplasms

Genetic Tests for Bone Cancer

Anatomical Context for Bone Cancer

MalaCards organs/tissues related to Bone Cancer:

Bone, Prostate, Breast, Lung, Brain, T Cells, Spinal Cord

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Cancer:


Publications for Bone Cancer

Articles related to Bone Cancer:

(show top 50) (show all 490)
# Title Authors Year
Adverse events associated with aprepitant pediatric bone cancer patients. ( 29409391 )
Health professional perceptions of communicating with adolescents and young adults about bone cancer clinical trial participation. ( 29978324 )
Fluoridation and county-level secondary bone cancer among cancer patients 18 years or older in New York State. ( 30109528 )
Bone-Cancer Assessment and Destruction Pattern Analysis in Long-Bone X-ray Image. ( 30367308 )
Decitabine attenuates nociceptive behavior in a murine model of bone cancer pain. ( 30422869 )
Pain: Persistent postsurgery and bone cancer-related pain. ( 30632434 )
Imbalanced spinal infiltration of Th17/Treg cells contributes to bone cancer pain via promoting microglial activation. ( 30685532 )
Brain and bone cancer targeting by a ferrofluid composed of superparamagnetic iron-oxide/silica/carbon nanoparticles (earthicles). ( 30711662 )
Neuroinflammation and central PI3K/Akt/mTOR signal pathway contribute to bone cancer pain. ( 30717619 )
Biological and toxicological evaluation of N-(4methyl-phenyl)-4-methylphthalimide on bone cancer in mice. ( 30734686 )
Upregulation of bone morphogenetic protein 2 ( Bmp2) in dorsal root ganglion in a rat model of bone cancer pain. ( 30799697 )
Thalidomide alleviates bone cancer pain by down-regulating expressions of NF-κB and GFAP in spinal astrocytes in a mouse model. ( 30806135 )
Comparative evaluation of magnetic hyperthermia performance and biocompatibility of magnetite and novel Fe-doped hardystonite nanoparticles for potential bone cancer therapy. ( 30813100 )
The roles of chemokine CXCL13 in the development of bone cancer pain and the regulation of morphine analgesia in rats. ( 30826523 )
Minocycline Relieves Depressive-Like Behaviors in Rats With Bone Cancer Pain by Inhibiting Microglia Activation in Hippocampus. ( 30829675 )
Growing Without Pain: The Noninvasive Expandable Prosthesis is Boon for Children with Bone Cancer, as well as Their Surgeons! ( 30905999 )
The short interference RNA (siRNA) targeting NMUR2 relieves nociception in a bone cancer pain model of rat through PKC-ERK and PI3K-AKT pathways. ( 30914203 )
XPro1595 ameliorates bone cancer pain in rats via inhibiting p38-mediated glial cell activation and neuroinflammation in the spinal dorsal horn. ( 31002915 )
Suppression of WNK1-SPAK/OSR1 attenuates bone cancer pain by regulating NKCC1 and KCC2. ( 31085334 )
Incidence and mortality of bone cancer among children, adolescents and young adults of Brazil. ( 31090796 )
Analgesic effects of microRNA-129-5p against bone cancer pain through the EphB1/EphrinB2 signaling pathway in mice. ( 29236320 )
Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain. ( 29300279 )
Longitudinal resting-state functional magnetic resonance imaging in a mouse model of metastatic bone cancer reveals distinct functional reorganizations along a developing chronic pain state. ( 29319607 )
Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer. ( 29357732 )
A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain Without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain. ( 29371114 )
Blockage of spinal endothelin A receptors attenuates bone cancer pain via regulation of the Akt/ERK signaling pathway in mice. ( 29395120 )
Socio-economic patterning in early mortality of patients aged 0-49 years diagnosed with primary bone cancer in Great Britain, 1985-2008. ( 29414632 )
Spinal PKC activation - Induced neuronal HMGB1 translocation contributes to hyperalgesia in a bone cancer pain model in rats. ( 29428215 )
Suppression of HDAC2 in Spinal Cord Alleviates Mechanical Hyperalgesia and Restores KCC2 Expression in a Rat Model of Bone Cancer Pain. ( 29482000 )
Expression of BDNF in dorsal root ganglion of rats with bone cancer pain and its effect on pain behavior. ( 29504577 )
A new method for selecting auricle positions in skull base reconstruction for temporal bone cancer. ( 29574745 )
Electrical peripheral nerve stimulation relieves bone cancer pain by inducing Arc protein expression in the spinal cord dorsal horn. ( 29606887 )
Hedgehog signaling contributes to bone cancer pain by regulating sensory neuron excitability in rats. ( 29607715 )
CORR Insights®: Can Augmented Reality Be Helpful in Pelvic Bone Cancer Surgery? An In Vitro Study. ( 29762155 )
18F-Fluoride PET/CT and 99mTc-MDP SPECT/CT can detect bone cancer at early stage in rodents. ( 29778807 )
Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice. ( 29867362 )
Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype. ( 29882480 )
Neuronal complement cascade drives bone cancer pain via C3R mediated microglial activation. ( 29909203 )
Activation of the P2X7 receptor in midbrain periaqueductal gray participates in the analgesic effect of tramadol in bone cancer pain rats. ( 30198382 )
Bone Cancer: Diagnosis and Treatment Principles. ( 30215968 )
Bone Cancer. ( 30215985 )
Bone morphogenetic protein and activin membrane-bound inhibitor suppress bone cancer progression in MG63 and SAOS cells via regulation of the TGF-β-induced EMT signaling pathway. ( 30250579 )
In vitro evaluation of a biomaterial-based anticancer drug delivery system as an alternative to conventional post-surgery bone cancer treatment. ( 30274043 )
Iodine-125 seed implantation combined with arterial chemoembolization therapy for pain palliation in metastatic bone cancer: a retrospective study. ( 30296196 )
SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission. ( 30579931 )
The antinociceptive effect of resveratrol in bone cancer pain is inhibited by the Silent Information Regulator 1 inhibitor selisistat. ( 30592048 )
Can Augmented Reality Be Helpful in Pelvic Bone Cancer Surgery? An In Vitro Study. ( 30794209 )
The perceptions of teenagers, young adults and professionals in the participation of bone cancer clinical trials. ( 26936110 )
Hyperthermia effect and antibacterial efficacy of Fe3+ /Co2+ co-substitutions in β-Ca3 (PO4 )2 for bone cancer and defect therapy. ( 28661574 )
Teniposide ameliorates bone cancer nociception in rats via the P2X7 receptor. ( 28825192 )

Variations for Bone Cancer

Copy number variations for Bone Cancer from CNVD:

# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 70082 12 58138784 58142025 Amplification SAS Bone cancer
2 70083 12 58141509 58146230 Amplification CDK4 Bone cancer
3 71134 12 67700000 68661632 Amplification MDM2 Bone cancer

Expression for Bone Cancer

Search GEO for disease gene expression data for Bone Cancer.

Pathways for Bone Cancer

Pathways related to Bone Cancer according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1 12.6 BMP2 CYCS ESR1 IL6 MMP9
Show member pathways
3 11.94 BMI1 EWSR1 IL6 MMP9
4 11.75 CCL2 IL6 MMP9
5 11.73 BMI1 BMP2 IL6
6 11.54 CCL2 IL6 MMP9 PDYN
7 11.48 CCL2 IL6 MMP9
8 11.41 CCL2 IL6 MMP9
9 11.15 IL6 TNFRSF11A TNFSF11
10 10.96 CCL2 IL6 MMP9
11 10.94 BMP2 CCL2 IL6 TNFSF11
12 10.88 CCL2 IL6 TNFRSF11A TNFSF11
13 10.8 BMP2 CCL2 IL6 PENK TNFSF11
14 10.71 TNFRSF11A TNFSF11

GO Terms for Bone Cancer

Biological processes related to Bone Cancer according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.95 BMP2 CCL2 IL6 P2RX7 TRPV1
2 cytokine-mediated signaling pathway GO:0019221 9.89 CCL2 IL6 MMP9 TNFSF11
3 positive regulation of gene expression GO:0010628 9.88 ATF3 BMP2 IL6 P2RX7 RLN2 TNFSF11
4 response to lipopolysaccharide GO:0032496 9.84 CNR1 P2RX7 PENK TNFRSF11A
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.83 IL6 TNFRSF11A TNFSF11 TRIM14
6 response to bacterium GO:0009617 9.8 BMP2 CCL2 P2RX7 PENK
7 positive regulation of apoptotic process GO:0043065 9.8 BMP2 CNR1 IL6 MMP9 P2RX7 TRPV1
8 osteoblast differentiation GO:0001649 9.77 BMP2 MRC2 PENK
9 cellular response to organic cyclic compound GO:0071407 9.73 BMP2 CCL2 P2RX7
10 ossification GO:0001503 9.73 BMP2 MMP9 TNFRSF11A TNFSF11
11 positive regulation of ossification GO:0045778 9.58 BMP2 P2RX7
12 negative regulation of bone resorption GO:0045779 9.58 IL6 P2RX7
13 PERK-mediated unfolded protein response GO:0036499 9.57 ATF3 CCL2
14 sensory perception of pain GO:0019233 9.56 CNR1 P2RX7 PENK TRPV1
15 mammary gland alveolus development GO:0060749 9.54 ESR1 TNFRSF11A TNFSF11
16 TNFSF11-mediated signaling pathway GO:0071847 9.51 TNFRSF11A TNFSF11
17 regulation of signaling receptor activity GO:0010469 9.5 BMP2 CCL2 IL6 PDYN PENK RLN2
18 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.48 TNFRSF11A TNFSF11
19 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.46 TNFRSF11A TNFSF11
20 monocyte chemotaxis GO:0002548 9.46 CCL2 IL6 TNFRSF11A TNFSF11
21 positive regulation of DNA-binding transcription factor activity GO:0051091 9.02 ESR1 IL6 TNFRSF11A TNFSF11 TRIM14

Molecular functions related to Bone Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 BMP2 CCL2 IL6 TNFSF11
2 opioid peptide activity GO:0001515 8.62 PDYN PENK

Sources for Bone Cancer

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
33 HPO
34 ICD10
35 ICD10 via Orphanet
39 LifeMap
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
56 Novoseek
59 OMIM via Orphanet
63 PubMed
71 SNOMED-CT via Orphanet
73 Tocris
75 UMLS via Orphanet
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