Aliases & Classifications for Bone Cancer

MalaCards integrated aliases for Bone Cancer:

Name: Bone Cancer 12 43 15
Bone Carcinoma 12 15 73
Malignant Bone Neoplasm 12 73
Bone Neoplasms 44 73
Malignant Neoplasm of Bone 12
Malignant Osseous Tumor 12
Malignant Bone Tumour 12
Osteosarcoma of Bone 73
Osteogenic Neoplasm 73
Ca - Bone Cancer 12
Neoplasm of Bone 12
Bone Neoplasm 12
Osseous Tumor 12
Bone Tumour 12


Summaries for Bone Cancer

MedlinePlus : 43 Cancer that starts in a bone is uncommon. Cancer that has spread to the bone from another part of the body is more common. There are three types of bone cancer: Osteosarcoma - occurs most often between ages 10 and 19. It is more common in the knee and upper arm. Chondrosarcoma - starts in cartilage, usually after age 40 Ewing's sarcoma - occurs most often in children and teens under 19. It is more common in boys than girls. The most common symptom of bone cancer is pain. Other symptoms vary, depending on the location and size of the cancer. Surgery is often the main treatment for bone cancer. Other treatments may include amputation, chemotherapy, and radiation therapy. Because bone cancer can come back after treatment, regular follow-up visits are important. NIH: National Cancer Institute

MalaCards based summary : Bone Cancer, also known as bone carcinoma, is related to ewing sarcoma and bone disease, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Bone Cancer is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are ERK Signaling and Pathways in cancer. The drugs Quadramet and Xgeva have been mentioned in the context of this disorder. Affiliated tissues include bone, bone and prostate, and related phenotypes are behavior/neurological and growth/size/body region

Disease Ontology : 12 A connective tissue cancer that is located in bone and is characterized by uncontrolled cellular proliferation that destroys normal bone tissue.

Related Diseases for Bone Cancer

Diseases related to Bone Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 89)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 31.0 CDKN2A CYCS EWSR1 IL6 MMP9
2 bone disease 29.8 COL1A1 IL6 TNFRSF11A TNFSF11
3 osteoporosis 29.2 COL1A1 ESR1 IL6 TNFRSF11A TNFSF11 TRPV1
4 chest wall bone cancer 12.0
5 primary bone cancer 12.0
6 bone marrow cancer 11.2
7 polyarticular onset juvenile idiopathic arthritis 11.0 TNFRSF11A TNFSF11
8 breast leiomyosarcoma 10.9 TNFRSF11A TNFSF11
9 hemophilic arthropathy 10.9 TNFRSF11A TNFSF11
10 maxillary neoplasm 10.8
11 paget disease of bone 5, juvenile-onset 10.8 TNFRSF11A TNFSF11
12 female reproductive system disease 10.8 ESR1 IL6 TRPV1
13 periapical periodontitis 10.8 IL6 TNFRSF11A TNFSF11
14 root resorption 10.8 P2RX7 TNFRSF11A TNFSF11
15 reproductive system disease 10.8 ESR1 IL6 TRPV1
16 periodontitis, chronic 10.8 IL6 TNFSF11
17 osteogenic sarcoma 10.8
18 mouth disease 10.7 IL6 TNFSF11 TRPV1
19 bone squamous cell carcinoma 10.7
20 dissociative amnesia 10.7 PDYN TNFSF11
21 osteoporotic fracture 10.7 COL1A1 ESR1 IL6
22 villonodular synovitis 10.7 MMP9 TNFSF11
23 diabetic foot ulcers 10.7 IL6 MMP9
24 bone remodeling disease 10.7 ESR1 TNFRSF11A TNFSF11 TRPV1
25 overnutrition 10.7 CCL2 IL6 TRPV1
26 urinary system disease 10.7 CCL2 IL6 TRPV1
27 familial expansile osteolysis 10.6 TNFRSF11A TNFSF11
28 endometriosis 10.6 CCL2 ESR1 IL6
29 rosacea 10.6 IL6 MMP9 TRPV1
30 chondrosarcoma 10.6
31 multiple enchondromatosis, maffucci type 10.6
32 bone fracture 10.6
33 long bones of lower limb cancer 10.6
34 jaw cancer 10.6
35 orbital cancer 10.6
36 bone giant cell tumor 10.6
37 sternum cancer 10.6
38 paget's disease of bone 10.6
39 femoral cancer 10.6
40 bone lymphoma 10.6
41 acquired metabolic disease 10.6 CCL2 IL6 TRPV1
42 giant cell tumor 10.6 MMP9 TNFRSF11A TNFSF11
43 connective tissue cancer 10.6 COL1A1 EWSR1 TRPV1
44 acute transverse myelitis 10.6 IL6 MMP9
45 bone inflammation disease 10.6 CCL2 IL6 TNFSF11 TRPV1
46 pelvic organ prolapse 10.5 COL1A1 ESR1 MMP9
47 chorioamnionitis 10.5 CCL2 IL6 MMP9
48 aortic aneurysm, familial abdominal, 1 10.5 CCL2 IL6 MMP9
49 atherosclerosis susceptibility 10.4 CCL2 ESR1 IL6
50 meningitis 10.4 CCL2 IL6 MMP9

Graphical network of the top 20 diseases related to Bone Cancer:

Diseases related to Bone Cancer

Symptoms & Phenotypes for Bone Cancer

UMLS symptoms related to Bone Cancer:

back pain, muscle cramp, sciatica

MGI Mouse Phenotypes related to Bone Cancer:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.36 P2RX7 PDYN MMP9 TNFSF11 PENK TRPV1
2 growth/size/body region MP:0005378 10.31 IL6 P2RX7 TNFRSF11A PDYN ESR1 MMP9
3 immune system MP:0005387 10.28 MMP9 TNFSF11 MRC2 TRPV1 MTAP IL6
4 cardiovascular system MP:0005385 10.24 IL6 P2RX7 ESR1 MMP9 PENK MTAP
5 homeostasis/metabolism MP:0005376 10.23 TRPV1 IL6 P2RX7 TNFRSF11A PDYN MMP9
6 hematopoietic system MP:0005397 10.22 IL6 P2RX7 TNFRSF11A ESR1 MMP9 TNFSF11
7 integument MP:0010771 10.18 PDYN MMP9 TNFSF11 PENK TRPV1 IL6
8 endocrine/exocrine gland MP:0005379 10.16 IL6 TNFRSF11A ESR1 TNFSF11 PENK ATF3
9 digestive/alimentary MP:0005381 10.07 IL6 TNFRSF11A PDYN MMP9 ESR1 COL1A1
10 adipose tissue MP:0005375 10.03 TRPV1 IL6 PDYN ESR1 ATF3 COL1A1
11 limbs/digits/tail MP:0005371 9.91 P2RX7 TNFRSF11A ESR1 MMP9 TNFSF11 PENK
12 neoplasm MP:0002006 9.91 MMP9 TNFSF11 TRPV1 IL6 TNFRSF11A CDKN2A
13 liver/biliary system MP:0005370 9.87 TRPV1 IL6 TNFRSF11A ESR1 MTAP COL1A1
14 no phenotypic analysis MP:0003012 9.81 TNFRSF11A PDYN TNFSF11 PENK TRPV1 CDKN2A
15 respiratory system MP:0005388 9.61 IL6 TNFRSF11A MMP9 TNFSF11 MTAP CDKN2A
16 skeleton MP:0005390 9.36 TNFRSF11A P2RX7 PDYN MMP9 TNFSF11 PENK

Drugs & Therapeutics for Bone Cancer

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
Quadramet 18 SAMARIUM SM-153 LEXIDRONAM PENTASODIUM DuPont Merck Pharmaceutical Company March 1997
Xgeva 18 49 DENOSUMAB Amgen June 2013/ November 2010
Xofigo 18 49 RADIUM RA-223 DICHLORIDE Bayer Healthcare Pharmaceuticals May 2013
Zometa 18 49 ZOLEDRONIC ACID Novartis August 2001/ February 2002

Drugs for Bone Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 441)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
Prednisone Approved, Vet_approved Phase 4,Phase 2,Phase 1 53-03-2 5865
Zoledronic acid Approved Phase 4,Phase 2,Phase 3,Phase 1 118072-93-8 68740
Dopamine Approved Phase 4,Phase 2 51-61-6, 62-31-7 681
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1 615258-40-7
Radium Ra 223 dichloride Approved, Investigational Phase 4,Phase 1,Phase 2 444811-40-9
Dalteparin Approved Phase 4,Not Applicable 9005-49-6
Heparin Approved, Investigational Phase 4,Not Applicable 9005-49-6 772 46507594
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
Enoxaparin Approved Phase 4 9005-49-6 772
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 1406-16-2
Butyric Acid Experimental, Investigational Phase 4 107-92-6 264
15 Anesthetics Phase 4,Phase 3,Phase 1,Not Applicable
16 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
18 Cortisol succinate Phase 4
19 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
20 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
21 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
23 Hydrocortisone 17-butyrate 21-propionate Phase 4
24 Hydrocortisone acetate Phase 4
25 Hydrocortisone-17-butyrate Phase 4
26 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
27 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
28 Diphosphonates Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
29 Calcium, Dietary Phase 4,Phase 1,Phase 2,Not Applicable
30 Vitamins Phase 4,Phase 2,Phase 1,Not Applicable
31 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
32 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
33 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
34 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
35 Adrenergic Agents Phase 4,Not Applicable
36 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1
37 Central Nervous System Stimulants Phase 4,Phase 2,Phase 1
38 Dopamine Agents Phase 4,Phase 2
39 Dopamine Uptake Inhibitors Phase 4
40 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
41 Neurotransmitter Uptake Inhibitors Phase 4
42 Ibandronic acid Phase 4,Phase 3,Phase 2
43 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Not Applicable
44 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
45 Antidepressive Agents Phase 4
46 Antimanic Agents Phase 4,Phase 1
47 Lithium carbonate Phase 4 554-13-2
48 Psychotropic Drugs Phase 4,Phase 1
49 Tranquilizing Agents Phase 4,Phase 1
50 Anticoagulants Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 726)
# Name Status NCT ID Phase Drugs
1 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
2 Bioactive Glass Granules in Filling of Bone Defects Completed NCT01304121 Phase 4
3 Long Term Efficacy and Safety of Zoledronic Acid Treatment in Patients With Bone Metastases Completed NCT00434447 Phase 4 Zoledronic acid
4 A Study to Assess the Short Term Efficacy of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Pain Due to Breast Cancer Completed NCT02553707 Phase 4 Ibandronate
5 A Study of Ibandronate (Bondronat) in Participants With Metastatic Bone Disease Completed NCT02564107 Phase 4 Ibandronate
6 FREE Study - Fracture Reduction Evaluation Completed NCT00211211 Phase 4
7 Effect of Zoledronic Acid as Anti-Cancer Treatment in Metastatic Breast Cancer Patients Completed NCT01129336 Phase 4 Zoledronic acid;Standard Therapy
8 Screening Non Small Cell Lung Cancer With Bone Metastasis and Efficacy and Safety Research of Receiving Bisphosphonates Completed NCT00765687 Phase 4 bisphosphates
9 Efficacy and Safety Study of ZOMETA® in Treatment of High-level NTX Non Small Cell Lung Cancer With Bone Metastasis Completed NCT00762346 Phase 4 zometa
10 Assessment of the Efficacy, Tolerability and Pharmaco-economic Impact of Zoledronic Acid Treatment in Prostate Cancer With Bone Metastasis Completed NCT00241111 Phase 4 zoledronic acid
11 Effect of Zoledronic Acid in Patients With Prostate Cancer and Bone Metastasis Completed NCT00237159 Phase 4 Zoledronic acid
12 Effect of Zoledronic Acid on Bone Metabolism in Patients With Bone Metastasis and Prostate or Breast Cancer Completed NCT00334139 Phase 4 Zoledronic Acid
13 Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma Recruiting NCT01669369 Phase 4 Lithium Carbonate;Placebo
14 Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004 Recruiting NCT03301857 Phase 4 Cohort A Denosumab
15 The Efficacy and Safety of PEG-rhG-CSF in Neutropenia After Chemotherapy Recruiting NCT02905916 Phase 4 PEG-rhG-CSF
16 Radium-223 Dichloride Long-term Follow-up Program Recruiting NCT02312960 Phase 4
17 Low Molecular Weight Heparin (LMWH) vs Aspirin for Venous Thromboembolism (VTE) Prophylaxis in Orthopaedic Oncology Enrolling by invitation NCT03244020 Phase 4 Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
18 Zoledronic Acid Combined Radiotherapy for Bone Metastasis of Non-small Cell Lung Cancer Not yet recruiting NCT02480634 Phase 4 Zoledronic acid
19 A Study To Evaluate Pregabalin In The Treatment Of Moderate To Severe Chronic Bone Pain Related To Metastatic Cancer Terminated NCT00381095 Phase 4 Pregabalin;Placebo
20 Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma Unknown status NCT00691236 Phase 2, Phase 3 Zoledronic acid;Standard chemotherapy
21 A Clinical Trial on Efficacy and Safety for Lobaplatin and Gemcitabine in Combination With Docetaxel in the Second-line Treatments on Advanced Osteosarcoma Unknown status NCT02099396 Phase 2, Phase 3 Docetaxel+lobaplatin;Gemcitabine+lobaplatin
22 Laser Therapy Prevents Mucositis Oral in Chemotherapy for Bone Marrow Transplantation? Unknown status NCT02020928 Phase 3
23 Non-invasive Focal Therapy for Osteoid Osteoma Unknown status NCT02302651 Phase 2, Phase 3
24 Biological Image Guided Antalgic Stereotactic Body Radiotherapy of Bone Metastases Unknown status NCT01429493 Phase 2, Phase 3
25 F18PET/CT Versus TC-MDP Scanning to Detect Bone Mets Unknown status NCT00882609 Phase 3
26 Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
27 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
28 Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement Unknown status NCT01813240 Phase 2, Phase 3 Minocycline;placebo
29 SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors Unknown status NCT00517959 Phase 3
30 Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy Completed NCT02711007 Phase 2, Phase 3 apatinib
31 Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children Completed NCT00180908 Phase 3 Etoposide, Ifosfamide, Methotrexate;Doxorubicin, Methotrexate
32 Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma Completed NCT01176981 Phase 3 High Dose Methotrexate
33 Osteosarcoma Study #2: A Randomized Trial of Pre-Surgical Chemotherapy vs. Immediate Surgery and Adjuvant Chemotherapy in the Treatment of Non-Metastatic Osteosarcoma. A Pediatric Oncology Group Phase III Study Completed NCT00001217 Phase 3 pre-surgical chemotherapy
34 Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma Completed NCT00002539 Phase 3 cisplatin;doxorubicin hydrochloride
35 Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Completed NCT00003937 Phase 3 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate
36 ExAblate (Magnetic Resonance-guided Focused Ultrasound Surgery) Treatment of Metastatic Bone Tumors for the Palliation of Pain Completed NCT00656305 Phase 3
37 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
38 A Study to Evaluate Renal Safety of Intravenous Ibandronate (Bondronat) in Participants With Metastatic Bone Disease Due to Breast Cancer Completed NCT02716792 Phase 3 Ibandronate
39 A Study of Ibandronate (Bondronat) in Participants With Malignant Bone Disease Completed NCT02561039 Phase 3 Ibandronate
40 Recombinant Human Keratinocyte Growth Factor to Reduce Oral Mucositis in Hematologic Malignancy Patients Undergoing Peripheral Blood Stem Cell Transplantation After Radiation and High-dose Chemotherapy Completed NCT00041665 Phase 3 Recombinant Human Keratinocyte Growth Factor
41 Ridaforolimus in Treatment of Sarcoma-SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus)(8669-011 AM6) Completed NCT00538239 Phase 3 ridaforolimus;Placebo
42 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
43 Dexamethasone for Pain Flare After Radiotherapy of Painful Bone metastasesZonMW 11510009 Completed NCT01669499 Phase 3 Dexamethasone acetate;Placebo
44 Palliation: the Effect of Education on Pain Completed NCT01358539 Phase 3
45 Dexamethasone vs Placebo in the Prophylaxis of Radiation-Induced Pain Flare Following Palliative Radiotherapy for Bone Metastases Completed NCT01248585 Phase 3 Dexamethasone;Placebo
46 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
47 Evaluation of Vertebroplasty Associated With Radiotherapy for Spine Metastases (EVAR) Completed NCT00267033 Phase 3
48 Palliative Radiotherapy for Bone Metastases: Single Versus Multiple Fractions. Completed NCT00858741 Phase 3
49 Optimization of Radiotherapy in Treatment of Painful Bone Metastasis Completed NCT00610272 Phase 3
50 Efficacy and Safety of Zoledronic Acid in Patients With Bone Metastases of Any Solid Tumors or Multiple Myeloma Completed NCT00219258 Phase 3 Zoledronic acid

Search NIH Clinical Center for Bone Cancer

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: bone neoplasms

Genetic Tests for Bone Cancer

Anatomical Context for Bone Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Cancer:


MalaCards organs/tissues related to Bone Cancer:

Bone, Prostate, Breast, Brain, Lung, T Cells, Spinal Cord

Publications for Bone Cancer

Articles related to Bone Cancer:

(show top 50) (show all 205)
# Title Authors Year
Suppression of HDAC2 in Spinal Cord Alleviates Mechanical Hyperalgesia and Restores KCC2 Expression in a Rat Model of Bone Cancer Pain. ( 29482000 )
Adverse events associated with aprepitant pediatric bone cancer patients. ( 29409391 )
A Kappa Opioid Receptor Agonist Blocks Bone Cancer Pain Without Altering Bone Loss, Tumor Size, or Cancer Cell Proliferation in a Mouse Model of Cancer-Induced Bone Pain. ( 29371114 )
Socio-economic patterning in early mortality of patients aged 0-49 years diagnosed with primary bone cancer in Great Britain, 1985-2008. ( 29414632 )
IL-18 Contributes to Bone Cancer Pain by Regulating Glia Cells and Neuron Interaction. ( 29079540 )
Longitudinal resting-state fMRI in a mouse model of metastatic bone cancer reveals distinct functional reorganizations along a developing chronic pain state. ( 29319607 )
Expression of BDNF in dorsal root ganglion of rats with bone cancer pain and its effect on pain behavior. ( 29504577 )
Inhibition of Connexin 43 and Phosphorylated NR2B in Spinal Astrocytes Attenuates Bone Cancer Pain in Mice. ( 29867362 )
Spinal PKC activation - Induced neuronal HMGB1 translocation contributes to hyperalgesia in a bone cancer pain model in rats. ( 29428215 )
CORR InsightsAr: Can Augmented Reality Be Helpful in Pelvic Bone Cancer Surgery? An In Vitro Study. ( 29762155 )
Lectin-conjugated pH-responsive mesoporous silica nanoparticles for targeted bone cancer treatment. ( 29127069 )
Hedgehog signaling contributes to bone cancer pain by regulating sensory neuron excitability in rats. ( 29607715 )
Activation of ventral tegmental area dopaminergic neurons reverses pathological allodynia resulting from nerve injury or bone cancer. ( 29357732 )
Electrical peripheral nerve stimulation relieves bone cancer pain by inducing Arc protein expression in the spinal cord dorsal horn. ( 29606887 )
Neuronal complement cascade drives bone cancer pain via C3R mediated microglial activation. ( 29909203 )
Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype. ( 29882480 )
<sup>18</sup>F-Fluoride PET/CT and <sup>99m</sup>Tc-MDP SPECT/CT can detect bone cancer at early stage in rodents. ( 29778807 )
Preconditioning with hydrogen sulfide prevents bone cancer pain in rats through a proliferator-activated receptor gamma/p38/Jun N-terminal kinase pathway. ( 29096563 )
Blockage of spinal endothelin A receptors attenuates bone cancer pain via regulation of the Akt/ERK signaling pathway in mice. ( 29395120 )
Health professional perceptions of communicating with adolescents and young adults about bone cancer clinical trial participation. ( 29978324 )
A new method for selecting auricle positions in skull base reconstruction for temporal bone cancer. ( 29574745 )
Upregulation of Spinal Voltage-Dependent Anion Channel 1 Contributes to Bone Cancer Pain Hypersensitivity in Rats. ( 29196874 )
STAT1 as a downstream mediator of ERK signaling contributes to bone cancer pain by regulating MHC II expression in spinal microglia. ( 27742579 )
Teniposide ameliorates bone cancer nociception in rats via the P2X7 receptor. ( 28825192 )
Effect of alkylaminophenols on growth inhibition and apoptosis of bone cancer cells. ( 28728976 )
Normalizing GDNF expression in the spinal cord alleviates cutaneous hyperalgesia but not ongoing pain in a rat model of bone cancer pain. ( 27716965 )
Recombinant protein transduction domain-Cu/Zn superoxide dismutase alleviates bone cancer pain via peroxiredoxin 4 modulation and antioxidation. ( 28391978 )
The Molecular Genetic Expression as a Novel Biomarker in the Evaluation and Monitoring of Patients With Osteosarcoma-Subtype Bone Cancer Disease. ( 28425009 )
Resveratrol attenuates bone cancer pain through regulating the expression levels of ASIC3 and activating cell autophagy. ( 29036449 )
Antinociceptive Effect of Intrathecal Injection of Genetically Engineered Human Bone Marrow Stem Cells Expressing the Human Proenkephalin Gene in a Rat Model of Bone Cancer Pain. ( 28286408 )
Bone cancer: Is the osteosarcoma genome targetable? ( 28776583 )
Efficacy and mechanism of action of etanercept in bone cancer pain. ( 29441991 )
Bindarit Attenuates Pain and Cancer-Related Inflammation by Influencing Myeloid Cells in a Model of Bone Cancer. ( 29234825 )
Morin Suppresses Astrocyte Activation and Regulates Cytokine Release in Bone Cancer Pain Rat Models. ( 28618070 )
Hyperthermia effect and antibacterial efficacy of Fe(3+) /Co(2+) co-substitutions in I^-Ca3 (PO4 )2 for bone cancer and defect therapy. ( 28661574 )
Plasma-induced selectivity in bone cancer cells death. ( 28571751 )
Multi-target treatment of bone cancer pain using synergistic combinations of pharmacological compounds in experimental animals. ( 28850433 )
The analgesic effects of triptolide in the bone cancer pain rats via inhibiting the upregulation of HDACs in spinal glial cells. ( 29096654 )
Retraction Statement: CXCL12/CXCR4 chemokine signaling in spinal glia induces pain hypersensitivity through MAPKs-mediated neuroinflammation in bone cancer rats. ( 28417467 )
Bufalin attenuates cancer-induced pain and bone destruction in a model of bone cancer. ( 28840279 )
Etanercept attenuates thermal and mechanical hyperalgesia induced by bone cancer. ( 28565880 )
Alleviating Mechanical Allodynia and Modulating Cellular Immunity Contribute to Electroacupuncture's Dual Effect on Bone Cancer Pain. ( 28870114 )
Spinal miRNA-124 regulates synaptopodin and nociception in an animal model of bone cancer pain. ( 28887457 )
DNMT3a contributes to the development and maintenance of bone cancer pain by silencing Kv1.2 expression in spinal cord dorsal horn. ( 29056068 )
Combined application of diclofenac and celecoxib with an opioid yields superior efficacy in metastatic bone cancer pain: a randomized controlled trial. ( 28484877 )
Vincristine-loaded hydroxyapatite nanoparticles as a potential delivery system for bone cancer therapy. ( 29098881 )
Disease modifying actions of interleukin-6 blockade in a rat model of bone cancer pain. ( 29300279 )
Analgesic effects of microRNA-129-5p against bone cancer pain through the EphB1/EphrinB2 signaling pathway in mice. ( 29236320 )
Simultaneous inhibition of NMDA and mGlu1/5 receptors by levo-corydalmine in rat spinal cord attenuates bone cancer pain. ( 28500623 )
Midazolam and ropivacaine act synergistically to inhibit bone cancer pain with different mechanisms in rats. ( 27841001 )

Variations for Bone Cancer

Copy number variations for Bone Cancer from CNVD:

# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 70082 12 58138784 58142025 Amplification SAS Bone cancer
2 70083 12 58141509 58146230 Amplification CDK4 Bone cancer
3 71134 12 67700000 68661632 Amplification MDM2 Bone cancer

Expression for Bone Cancer

Search GEO for disease gene expression data for Bone Cancer.

Pathways for Bone Cancer

GO Terms for Bone Cancer

Biological processes related to Bone Cancer according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.93 CCL2 IL6 P2RX7 TNFRSF11A TRPV1
2 positive regulation of gene expression GO:0010628 9.91 ATF3 CDKN2A IL6 P2RX7 RLN2
3 positive regulation of apoptotic process GO:0043065 9.89 CDKN2A IL6 MMP9 P2RX7 TRPV1
4 regulation of signaling receptor activity GO:0010469 9.8 CCL2 IL6 PDYN PENK RLN2 TNFSF11
5 osteoblast differentiation GO:0001649 9.77 COL1A1 MRC2 PENK
6 response to estradiol GO:0032355 9.76 COL1A1 ESR1 PENK
7 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 IL6 TNFRSF11A TNFSF11 TRIM14
8 collagen catabolic process GO:0030574 9.72 COL1A1 MMP9 MRC2
9 sensory perception of pain GO:0019233 9.7 P2RX7 PENK TRPV1
10 positive regulation of bone resorption GO:0045780 9.6 TNFRSF11A TNFSF11
11 negative regulation of bone resorption GO:0045779 9.58 IL6 P2RX7
12 sensory perception GO:0007600 9.57 PDYN PENK
13 PERK-mediated unfolded protein response GO:0036499 9.56 ATF3 CCL2
14 ossification GO:0001503 9.56 COL1A1 MMP9 TNFRSF11A TNFSF11
15 TNFSF11-mediated signaling pathway GO:0071847 9.48 TNFRSF11A TNFSF11
16 tooth eruption GO:0044691 9.46 COL1A1 TNFSF11
17 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.4 TNFRSF11A TNFSF11
18 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.37 TNFRSF11A TNFSF11
19 mammary gland alveolus development GO:0060749 9.33 ESR1 TNFRSF11A TNFSF11
20 monocyte chemotaxis GO:0002548 9.26 CCL2 IL6 TNFRSF11A TNFSF11
21 positive regulation of DNA binding transcription factor activity GO:0051091 9.02 ESR1 IL6 TNFRSF11A TNFSF11 TRIM14

Molecular functions related to Bone Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 opioid peptide activity GO:0001515 8.96 PDYN PENK
2 opioid receptor binding GO:0031628 8.62 PDYN PENK
3 protein binding GO:0005515 10.09 ATF3 BMI1 CCL2 CDKN2A COL1A1 CYCS

Sources for Bone Cancer

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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