MCID: BNC005
MIFTS: 23

Bone Chondrosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Chondrosarcoma

MalaCards integrated aliases for Bone Chondrosarcoma:

Name: Bone Chondrosarcoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050897

Summaries for Bone Chondrosarcoma

Disease Ontology : 12 A chondrosarcoma that is located in bone.

MalaCards based summary : Bone Chondrosarcoma is related to chondrosarcoma and cartilage disease. An important gene associated with Bone Chondrosarcoma is COMP (Cartilage Oligomeric Matrix Protein), and among its related pathways/superpathways are Circadian entrainment and G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins. Affiliated tissues include bone and bone.

Related Diseases for Bone Chondrosarcoma

Diseases related to Bone Chondrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 30.4 MMP1 MMP13
2 cartilage disease 10.1 ACAN COMP
3 achondrogenesis, type ii 10.1 ACAN COMP
4 transient arthritis 10.1 ACAN COMP
5 hypochondrogenesis 10.1 ACAN COMP
6 epiphyseal dysplasia, multiple, 1 10.1 ACAN COMP
7 pseudoachondroplasia 10.1 ACAN COMP
8 achondroplasia 10.1 ACAN COMP
9 odontogenic myxoma 10.1 ACAN MMP1
10 multiple epiphyseal dysplasia 10.1 ACAN COMP
11 arthropathy 10.0 ACAN COMP
12 bone deterioration disease 10.0 ACAN MMP13
13 bone structure disease 10.0 ACAN MMP13
14 localized scleroderma 10.0 MMP1 MMP13
15 coronary artery aneurysm 10.0 MMP1 MMP13
16 metaphyseal chondrodysplasia, schmid type 10.0 COMP RUNX2
17 mitral valve disease 10.0 MMP1 MMP13
18 inguinal hernia 9.9 MMP1 MMP13
19 psoriatic arthritis 9.9 COMP MMP1
20 ischemic bone disease 9.9 ACAN RUNX2
21 aortic aneurysm, familial abdominal, 1 9.9 MMP1 MMP13
22 bone development disease 9.9 COMP RUNX2
23 osteochondritis dissecans 9.9 ACAN COMP MMP13
24 synovitis 9.9 COMP MMP1 MMP13
25 arthritis 9.8 ACAN MMP1 MMP13
26 aortic valve disease 1 9.8 ACAN RUNX2
27 periodontitis 9.8 MMP1 RUNX2
28 squamous cell carcinoma 9.8
29 paget's disease of bone 9.8
30 brachydactyly 9.8 COMP RUNX2
31 rheumatoid arthritis 9.8 COMP MMP1 MMP13
32 tooth agenesis 9.8 MMP1 MMP13
33 spondyloepiphyseal dysplasia congenita 9.7 COMP MMP13 RUNX2
34 bone disease 9.7 ACAN MMP13 RUNX2
35 bone inflammation disease 9.7 ACAN COMP MMP1 MMP13
36 osteoarthritis 9.7 ACAN COMP MMP1 MMP13

Graphical network of the top 20 diseases related to Bone Chondrosarcoma:



Diseases related to Bone Chondrosarcoma

Symptoms & Phenotypes for Bone Chondrosarcoma

Drugs & Therapeutics for Bone Chondrosarcoma

Search Clinical Trials , NIH Clinical Center for Bone Chondrosarcoma

Genetic Tests for Bone Chondrosarcoma

Anatomical Context for Bone Chondrosarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Chondrosarcoma:

19
Bone

MalaCards organs/tissues related to Bone Chondrosarcoma:

41
Bone

Publications for Bone Chondrosarcoma

Articles related to Bone Chondrosarcoma:

# Title Authors Year
1
Temporal bone chondrosarcoma: Presentation of 4 cases and review of the literature. ( 25531842 )
2014
2
Primary multipotential malignant neoplasm of bone: chondrosarcoma associated with squamous cell carcinoma. ( 2419240 )
1986

Variations for Bone Chondrosarcoma

Expression for Bone Chondrosarcoma

Search GEO for disease gene expression data for Bone Chondrosarcoma.

Pathways for Bone Chondrosarcoma

GO Terms for Bone Chondrosarcoma

Cellular components related to Bone Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 ACAN COMP CTSD MMP1 MMP13
2 lysosomal lumen GO:0043202 9.26 ACAN CTSD
3 collagen-containing extracellular matrix GO:0062023 9.13 ACAN COMP CTSD
4 extracellular matrix GO:0031012 8.92 ACAN COMP MMP1 MMP13

Biological processes related to Bone Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.62 ACAN CTSD MMP1 MMP13
2 extracellular matrix disassembly GO:0022617 9.4 MMP1 MMP13
3 endochondral ossification GO:0001958 9.37 MMP13 RUNX2
4 skeletal system development GO:0001501 9.33 ACAN COMP RUNX2
5 chondrocyte development GO:0002063 9.26 ACAN RUNX2
6 growth plate cartilage development GO:0003417 8.96 COMP MMP13
7 collagen catabolic process GO:0030574 8.8 CTSD MMP1 MMP13

Molecular functions related to Bone Chondrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.54 ACAN COMP MMP13
2 peptidase activity GO:0008233 9.33 CTSD MMP1 MMP13
3 extracellular matrix structural constituent GO:0005201 9.32 ACAN COMP
4 metalloendopeptidase activity GO:0004222 9.26 MMP1 MMP13
5 collagen binding GO:0005518 8.96 COMP MMP13
6 serine-type endopeptidase activity GO:0004252 8.8 CTSD MMP1 MMP13

Sources for Bone Chondrosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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