MCID: BND004
MIFTS: 28

Bone Deterioration Disease

Categories: Bone diseases

Aliases & Classifications for Bone Deterioration Disease

MalaCards integrated aliases for Bone Deterioration Disease:

Name: Bone Deterioration Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080007

Summaries for Bone Deterioration Disease

Disease Ontology : 12 A bone structure disease that results in change or damage of structure located in bone.

MalaCards based summary : Bone Deterioration Disease is related to degenerative disc disease and spinal stenosis. An important gene associated with Bone Deterioration Disease is IVD (Isovaleryl-CoA Dehydrogenase), and among its related pathways/superpathways are ERK Signaling and Phospholipase-C Pathway. Affiliated tissues include bone and bone, and related phenotypes are cardiovascular system and craniofacial

Related Diseases for Bone Deterioration Disease

Diseases related to Bone Deterioration Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 degenerative disc disease 31.1 ACAN BMP2 COL9A3 GDF5 SOX9
2 spinal stenosis 30.3 ACAN BMP7 COL2A1 COL9A2 COL9A3 MMP3
3 bone chondrosarcoma 10.4 ACAN MMP13
4 polyradiculopathy 10.2 ACAN BMP2 IVD
5 hydrarthrosis 10.2 IL1B MMP13 MMP3
6 chondrosarcoma 10.2 MMP13 MMP3 SOX9
7 frozen shoulder 10.2 GDF5 IL1B MMP3
8 achondrogenesis, type ia 10.2 ACAN COL2A1
9 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.2 COL9A2 COL9A3
10 synovitis 10.2 IL1B MMP13 MMP3
11 brachydactyly, type a2 10.1 BMP2 GDF5 MMP3
12 autosomal recessive stickler syndrome 10.1 COL9A2 COL9A3
13 epiphyseal dysplasia, multiple, 2 10.1 COL9A2 COL9A3
14 epiphyseal dysplasia, multiple, 3 10.1 COL9A2 COL9A3
15 scheuermann disease 10.1 COL2A1 COL9A3
16 coxa vara 10.1 COL2A1 MMP13
17 stapes ankylosis with broad thumbs and toes 10.1 BMP7 CILP
18 cartilage disease 10.1 ACAN COL2A1
19 epiphyseal dysplasia, multiple, 4 10.1 COL9A2 COL9A3
20 pseudoarthrosis 10.1 BMP2 BMP7
21 epiphyseal dysplasia, multiple, 5 10.1 COL9A2 COL9A3
22 epiphyseal dysplasia, multiple, 1 10.0 ACAN COL9A2 COL9A3
23 tympanosclerosis 10.0 BMP2 COL2A1
24 pseudoachondroplasia 10.0 ACAN COL9A2 COL9A3
25 ischemic bone disease 10.0 ACAN BMP2 COL2A1
26 achondrogenesis 10.0 COL2A1 COL9A2
27 simpson-golabi-behmel syndrome, type 1 10.0 ACAN COL2A1
28 atelosteogenesis 10.0 COL9A2 IVD
29 synovial chondromatosis 10.0 BMP2 COL2A1 SOX9
30 brachydactyly 10.0 BMP2 COL2A1 GDF5
31 corneal ulcer 9.9 IL1B MMP3
32 vitreoretinal degeneration 9.9 COL2A1 COL9A2
33 stickler syndrome 9.9 COL2A1 COL9A2 COL9A3
34 bone development disease 9.8 COL2A1 COL9A2 GDF5 SOX9
35 intervertebral disc disease 9.8 CILP COL9A2 COL9A3 IL1B
36 arthritis 9.8 ACAN COL2A1 IL1B MMP13 MMP3
37 osteonecrosis 9.8 BMP2 BMP7 COL2A1
38 multiple epiphyseal dysplasia 9.8 ACAN COL2A1 COL9A2 COL9A3
39 spondylolysis 9.7 BMP7 FTH1 GDF5
40 bone inflammation disease 9.6 ACAN COL2A1 IL1B MMP13 MMP3 SOX9
41 osteochondritis dissecans 9.4 ACAN BMP7 COL9A2 COL9A3 MMP13 MMP3
42 bone disease 9.4 ACAN BMP7 COL2A1 GDF5 IL1B MMP13
43 osteoarthritis 9.3 ACAN CILP COL2A1 GDF5 IL1B MMP13
44 spondylolisthesis 9.2 BMP2 BMP7 FTH1 GDF5 IVD MMP3
45 bone structure disease 7.3 ACAN BMP2 BMP7 CILP COL2A1 COL9A2

Graphical network of the top 20 diseases related to Bone Deterioration Disease:



Diseases related to Bone Deterioration Disease

Symptoms & Phenotypes for Bone Deterioration Disease

MGI Mouse Phenotypes related to Bone Deterioration Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 ADAMTS3 BMP2 BMP7 COL2A1 FTH1 IL1B
2 craniofacial MP:0005382 9.73 ADAMTS3 BMP2 BMP7 COL2A1 IL1B SOX9
3 hearing/vestibular/ear MP:0005377 9.63 ADAMTS3 BMP2 BMP7 COL2A1 COL9A2 SOX9
4 limbs/digits/tail MP:0005371 9.5 BMP2 BMP7 COL2A1 COL9A2 GDF5 MMP13
5 skeleton MP:0005390 9.32 ADAMTS3 BMP2 BMP7 COL2A1 COL9A2 GDF5

Drugs & Therapeutics for Bone Deterioration Disease

Search Clinical Trials , NIH Clinical Center for Bone Deterioration Disease

Genetic Tests for Bone Deterioration Disease

Anatomical Context for Bone Deterioration Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Deterioration Disease:

20
Bone

MalaCards organs/tissues related to Bone Deterioration Disease:

42
Bone

Publications for Bone Deterioration Disease

Variations for Bone Deterioration Disease

Expression for Bone Deterioration Disease

Search GEO for disease gene expression data for Bone Deterioration Disease.

Pathways for Bone Deterioration Disease

Pathways related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.63 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3
2
Show member pathways
12.76 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3
3
Show member pathways
12.57 ADAMTS3 COL2A1 COL9A2 COL9A3 MMP13 MMP3
4
Show member pathways
12.52 BMP2 BMP7 GDF5 IL1B
5
Show member pathways
12.05 BMP2 BMP7 GDF5 IL1B
6
Show member pathways
11.98 ACAN ADAMTS3 BMP2 BMP7 COL2A1 COL9A2
7 11.97 BMP2 BMP7 GDF5
8
Show member pathways
11.94 COL2A1 COL9A2 COL9A3
9
Show member pathways
11.9 ACAN COL2A1 COL9A2 COL9A3 IL1B MMP13
10
Show member pathways
11.87 BMP2 BMP7 GDF5 IL1B
11
Show member pathways
11.82 ACAN IL1B MMP3
12 11.78 ACAN COL2A1 IL1B SOX9
13 11.71 BMP7 COL2A1 SOX9
14 11.63 BMP2 BMP7 GDF5
15
Show member pathways
11.52 BMP2 BMP7 GDF5
16 11.42 COL2A1 MMP13 MMP3
17 11.36 ACAN COL9A2 COL9A3
18 11.17 ACAN BMP7 COL2A1 MMP13 SOX9
19 10.99 BMP2 BMP7
20 10.92 BMP2 BMP7
21 10.89 BMP2 COL2A1
22 10.66 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3

GO Terms for Bone Deterioration Disease

Cellular components related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.9 ADAMTS3 BMP2 BMP7 CILP COL2A1 COL9A2
2 collagen-containing extracellular matrix GO:0062023 9.72 ACAN ADAMTS3 BMP7 CILP COL2A1
3 basement membrane GO:0005604 9.58 ACAN COL2A1 COL9A2
4 collagen trimer GO:0005581 9.56 COL2A1 COL9A2 COL9A3 MMP13
5 extracellular matrix GO:0031012 9.5 ACAN ADAMTS3 COL2A1 COL9A2 COL9A3 MMP13
6 extracellular region GO:0005576 9.44 ACAN ADAMTS3 BMP2 BMP7 CILP COL2A1
7 collagen type IX trimer GO:0005594 9.37 COL9A2 COL9A3

Biological processes related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.97 BMP2 BMP7 FTH1 IL1B SOX9
2 regulation of apoptotic process GO:0042981 9.93 BMP2 BMP7 GDF5 SOX9
3 central nervous system development GO:0007417 9.85 ACAN COL2A1 SOX9
4 positive regulation of neuron differentiation GO:0045666 9.82 BMP2 BMP7 GDF5
5 BMP signaling pathway GO:0030509 9.8 BMP2 BMP7 GDF5
6 cell development GO:0048468 9.77 BMP2 BMP7 GDF5
7 regulation of MAPK cascade GO:0043408 9.76 BMP2 BMP7 GDF5
8 SMAD protein signal transduction GO:0060395 9.75 BMP2 BMP7 GDF5
9 extracellular matrix organization GO:0030198 9.72 ACAN COL2A1 COL9A2 COL9A3 SOX9
10 ossification GO:0001503 9.71 BMP2 BMP7 COL2A1 SOX9
11 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.7 BMP2 BMP7 GDF5
12 endochondral ossification GO:0001958 9.69 COL2A1 MMP13
13 collagen fibril organization GO:0030199 9.69 ACAN ADAMTS3 COL2A1
14 negative regulation of neurogenesis GO:0050768 9.68 BMP7 IL1B
15 positive regulation of chondrocyte differentiation GO:0032332 9.68 GDF5 SOX9
16 tissue homeostasis GO:0001894 9.68 COL2A1 SOX9
17 negative regulation of chondrocyte differentiation GO:0032331 9.67 GDF5 SOX9
18 chondrocyte development GO:0002063 9.67 ACAN SOX9
19 positive regulation of epithelial to mesenchymal transition GO:0010718 9.67 BMP2 BMP7 IL1B
20 endocardial cushion morphogenesis GO:0003203 9.66 BMP2 SOX9
21 positive regulation of cartilage development GO:0061036 9.66 BMP2 SOX9
22 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.65 BMP7 IL1B
23 epithelial to mesenchymal transition GO:0001837 9.65 BMP2 BMP7 SOX9
24 limb bud formation GO:0060174 9.64 COL2A1 SOX9
25 notochord development GO:0030903 9.64 COL2A1 SOX9
26 collagen catabolic process GO:0030574 9.63 ADAMTS3 MMP13 MMP3
27 embryonic skeletal joint morphogenesis GO:0060272 9.62 BMP7 COL2A1
28 mesenchymal cell differentiation GO:0048762 9.62 BMP2 BMP7
29 negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569 9.61 BMP2 CILP
30 proteoglycan metabolic process GO:0006029 9.61 BMP2 COL2A1
31 otic vesicle development GO:0071599 9.6 COL2A1 SOX9
32 negative regulation of mesenchymal cell apoptotic process GO:2001054 9.56 GDF5 SOX9
33 chondrocyte differentiation GO:0002062 9.56 BMP2 COL2A1 GDF5 SOX9
34 anterior head development GO:0097065 9.55 COL2A1 SOX9
35 mesenchyme development GO:0060485 9.54 BMP2 BMP7
36 cartilage condensation GO:0001502 9.54 ACAN COL2A1 SOX9
37 cellular response to BMP stimulus GO:0071773 9.46 BMP2 BMP7 COL2A1 SOX9
38 monocyte aggregation GO:0070487 9.43 BMP7 IL1B
39 skeletal system development GO:0001501 9.43 ACAN BMP2 BMP7 COL2A1 COL9A2 SOX9
40 response to vitamin D GO:0033280 9.37 BMP7
41 positive regulation of astrocyte differentiation GO:0048711 9.35 BMP2
42 cartilage development GO:0051216 9.1 BMP2 BMP7 COL2A1 GDF5 MMP13 SOX9

Molecular functions related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 BMP2 BMP7 GDF5 IL1B
2 metalloendopeptidase activity GO:0004222 9.54 ADAMTS3 MMP13 MMP3
3 transforming growth factor beta receptor binding GO:0005160 9.33 BMP2 BMP7 GDF5
4 BMP receptor binding GO:0070700 9.32 BMP2 BMP7
5 extracellular matrix structural constituent conferring tensile strength GO:0030020 9.13 COL2A1 COL9A2 COL9A3
6 extracellular matrix structural constituent GO:0005201 9.02 ACAN CILP COL2A1 COL9A2 COL9A3

Sources for Bone Deterioration Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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