MCID: BND004
MIFTS: 28

Bone Deterioration Disease

Categories: Bone diseases

Aliases & Classifications for Bone Deterioration Disease

MalaCards integrated aliases for Bone Deterioration Disease:

Name: Bone Deterioration Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080007

Summaries for Bone Deterioration Disease

Disease Ontology : 12 A bone structure disease that results in change or damage of structure located in bone.

MalaCards based summary : Bone Deterioration Disease is related to degenerative disc disease and spinal stenosis. An important gene associated with Bone Deterioration Disease is IVD (Isovaleryl-CoA Dehydrogenase), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. Affiliated tissues include bone and bone, and related phenotypes are homeostasis/metabolism and limbs/digits/tail

Related Diseases for Bone Deterioration Disease

Diseases related to Bone Deterioration Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 degenerative disc disease 30.9 ACAN BMP2 COL9A3 GDF5 SOX9
2 spinal stenosis 27.8 ACAN BMP7 COL2A1 COL9A2 COL9A3 MMP3
3 polyradiculopathy 10.6 ACAN BMP2 IVD
4 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.5 COL9A2 COL9A3
5 superior limbic keratoconjunctivitis 10.5 MMP1 MMP3
6 spastic entropion 10.4 MMP1 MMP3
7 frozen shoulder 10.4 GDF5 IL1B MMP3
8 autosomal recessive stickler syndrome 10.4 COL9A2 COL9A3
9 achondrogenesis, type ia 10.4 ACAN COL2A1
10 coxa vara 10.3 COL2A1 MMP13
11 scheuermann disease 10.3 COL2A1 COL9A3
12 cartilage disease 10.3 ACAN COL2A1
13 uruguay faciocardiomusculoskeletal syndrome 10.3 BMP7 CILP
14 tympanosclerosis 10.2 BMP2 COL2A1
15 pseudoachondroplasia 10.2 ACAN COL9A2 COL9A3
16 back pain 10.2 CILP COL9A2 COL9A3
17 periodontitis, chronic 10.2 IL1B MMP1
18 coronary artery aneurysm 10.2 MMP1 MMP13 MMP3
19 ischemic bone disease 10.2 ACAN BMP2 COL2A1
20 synovial chondromatosis 10.1 BMP2 COL2A1 SOX9
21 corneal edema 10.1 IL1B MMP1 MMP3
22 adult astrocytic tumour 10.0 MMP1 MMP3
23 proximal symphalangism 10.0 BMP2 BMP7 GDF5
24 achondrogenesis 10.0 COL2A1 COL9A2
25 chondrosarcoma 10.0 MMP1 MMP13 MMP3 SOX9
26 brachydactyly 9.9 BMP2 COL2A1 GDF5
27 adenomyosis 9.9 MMP1 MMP3
28 vitreoretinal degeneration 9.9 COL2A1 COL9A2
29 sorsby fundus dystrophy 9.9 MMP13 MMP3 TIMP1
30 psoriatic arthritis 9.9 IL1B MMP1 MMP3
31 stickler syndrome 9.9 COL2A1 COL9A2 COL9A3
32 spondylolysis 9.9 BMP7 FTH1 GDF5
33 corneal ulcer 9.9 IL1B MMP3
34 synovitis 9.8 IL1B MMP1 MMP13 MMP3
35 tooth agenesis 9.8 BMP2 MMP1 MMP13
36 intervertebral disc disease 9.8 CILP COL9A2 COL9A3 IL1B
37 bone development disease 9.8 COL2A1 COL9A2 GDF5 SOX9
38 joint disorders 9.7 IL1B MMP3 TIMP1
39 multiple epiphyseal dysplasia 9.7 ACAN COL2A1 COL9A2 COL9A3
40 osteonecrosis 9.6 BMP2 BMP7 COL2A1
41 conjunctivochalasis 9.6 MMP1 MMP3 TIMP1
42 tendinosis 9.5 MMP1 MMP3 TIMP1
43 gingival overgrowth 9.5 MMP1 MMP3 TIMP1
44 varicose veins 9.5 MMP1 MMP3 TIMP1
45 gingival fibromatosis 9.5 MMP1 MMP3 TIMP1
46 inguinal hernia 9.5 MMP1 MMP13 TIMP1
47 gingival disease 9.4 IL1B MMP1 TIMP1
48 fibrosarcoma 9.3 MMP1 MMP3 TIMP1
49 periodontitis 9.1 IL1B MMP1 MMP3 TIMP1
50 periodontal disease 9.1 IL1B MMP1 MMP3 TIMP1

Graphical network of the top 20 diseases related to Bone Deterioration Disease:



Diseases related to Bone Deterioration Disease

Symptoms & Phenotypes for Bone Deterioration Disease

MGI Mouse Phenotypes related to Bone Deterioration Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.9 IVD MMP1 MMP13 MMP3 SOX9 TIMP1
2 limbs/digits/tail MP:0005371 9.56 MMP13 SOX9 TIMP1 BMP2 BMP7 COL2A1
3 skeleton MP:0005390 9.32 MMP13 MMP3 SOX9 TIMP1 BMP2 BMP7

Drugs & Therapeutics for Bone Deterioration Disease

Search Clinical Trials , NIH Clinical Center for Bone Deterioration Disease

Genetic Tests for Bone Deterioration Disease

Anatomical Context for Bone Deterioration Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Deterioration Disease:

19
Bone

MalaCards organs/tissues related to Bone Deterioration Disease:

41
Bone

Publications for Bone Deterioration Disease

Variations for Bone Deterioration Disease

Expression for Bone Deterioration Disease

Search GEO for disease gene expression data for Bone Deterioration Disease.

Pathways for Bone Deterioration Disease

Pathways related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

(show all 28)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3
2
Show member pathways
13.27 ACAN COL2A1 COL9A2 COL9A3 MMP1 MMP13
3
Show member pathways
12.75 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3
4
Show member pathways
12.7 COL2A1 COL9A2 COL9A3 MMP13 MMP3
5
Show member pathways
12.53 BMP2 BMP7 GDF5 IL1B TIMP1
6
Show member pathways
12.19 IL1B MMP1 MMP13 MMP3
7
Show member pathways
12.02 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3
8
Show member pathways
12.01 MMP1 MMP13 MMP3 TIMP1
9
Show member pathways
11.89 BMP2 BMP7 GDF5 IL1B TIMP1
10 11.8 BMP7 COL2A1 SOX9
11 11.78 ACAN COL2A1 IL1B SOX9
12 11.74 IL1B MMP1 MMP3
13 11.73 IL1B MMP1 MMP3 TIMP1
14 11.72 MMP13 MMP3 TIMP1
15 11.69 BMP2 BMP7 GDF5
16
Show member pathways
11.62 MMP1 MMP13 MMP3 TIMP1
17
Show member pathways
11.61 BMP2 BMP7 GDF5
18 11.52 BMP7 IL1B TIMP1
19
Show member pathways
11.51 IL1B MMP1 MMP3
20 11.46 ACAN COL9A2 COL9A3
21 11.37 ACAN BMP7 COL2A1 MMP13 SOX9
22 11.2 ACAN MMP1 MMP3
23 11.14 COL2A1 MMP1 MMP13 MMP3 TIMP1
24 11.04 BMP2 BMP7
25 11.03 IL1B TIMP1
26 10.97 BMP2 BMP7
27 10.94 BMP2 COL2A1
28 10.9 MMP1 TIMP1

GO Terms for Bone Deterioration Disease

Cellular components related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 BMP2 BMP7 CILP COL2A1 GDF5 IL1B
2 extracellular region GO:0005576 9.77 ACAN BMP2 BMP7 COL2A1 COL9A2 COL9A3
3 endoplasmic reticulum lumen GO:0005788 9.67 COL2A1 COL9A2 COL9A3 TIMP1
4 collagen trimer GO:0005581 9.55 COL2A1 COL9A2 COL9A3 MMP13 TIMP1
5 collagen type IX trimer GO:0005594 9.32 COL9A2 COL9A3
6 extracellular matrix GO:0031012 9.23 ACAN BMP7 CILP COL2A1 MMP1 MMP13

Biological processes related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 BMP2 BMP7 IL1B SOX9
2 regulation of signaling receptor activity GO:0010469 9.99 BMP2 BMP7 GDF5 IL1B TIMP1
3 regulation of apoptotic process GO:0042981 9.97 BMP2 BMP7 GDF5 SOX9
4 cytokine-mediated signaling pathway GO:0019221 9.96 IL1B MMP1 MMP3 TIMP1
5 negative regulation of cell proliferation GO:0008285 9.96 BMP2 BMP7 FTH1 IL1B SOX9
6 central nervous system development GO:0007417 9.86 ACAN COL2A1 SOX9
7 BMP signaling pathway GO:0030509 9.82 BMP2 BMP7 GDF5
8 positive regulation of neuron differentiation GO:0045666 9.81 BMP2 BMP7 GDF5
9 extracellular matrix organization GO:0030198 9.8 ACAN COL2A1 COL9A2 COL9A3 SOX9
10 SMAD protein signal transduction GO:0060395 9.76 BMP2 BMP7 GDF5
11 cell development GO:0048468 9.75 BMP2 BMP7 GDF5
12 regulation of MAPK cascade GO:0043408 9.74 BMP2 BMP7 GDF5
13 ossification GO:0001503 9.73 BMP2 BMP7 COL2A1 SOX9
14 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.69 BMP2 BMP7 GDF5
15 cartilage condensation GO:0001502 9.68 COL2A1 SOX9
16 positive regulation of chondrocyte differentiation GO:0032332 9.68 GDF5 SOX9
17 tissue homeostasis GO:0001894 9.67 COL2A1 SOX9
18 negative regulation of chondrocyte differentiation GO:0032331 9.67 GDF5 SOX9
19 positive regulation of epithelial to mesenchymal transition GO:0010718 9.67 BMP2 BMP7 IL1B
20 collagen catabolic process GO:0030574 9.67 COL2A1 MMP1 MMP13 MMP3
21 positive regulation of protein oligomerization GO:0032461 9.66 MMP1 MMP3
22 endocardial cushion morphogenesis GO:0003203 9.65 BMP2 SOX9
23 positive regulation of cartilage development GO:0061036 9.65 BMP2 SOX9
24 epithelial to mesenchymal transition GO:0001837 9.65 BMP2 BMP7 SOX9
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.64 BMP7 IL1B
26 limb bud formation GO:0060174 9.63 COL2A1 SOX9
27 embryonic skeletal joint morphogenesis GO:0060272 9.63 BMP7 COL2A1
28 notochord development GO:0030903 9.62 COL2A1 SOX9
29 mesenchymal cell differentiation GO:0048762 9.62 BMP2 BMP7
30 chondrocyte differentiation GO:0002062 9.62 BMP2 COL2A1 GDF5 SOX9
31 negative regulation of insulin-like growth factor receptor signaling pathway GO:0043569 9.61 BMP2 CILP
32 proteoglycan metabolic process GO:0006029 9.61 BMP2 COL2A1
33 otic vesicle development GO:0071599 9.6 COL2A1 SOX9
34 cellular response to BMP stimulus GO:0071773 9.56 BMP2 BMP7 COL2A1 SOX9
35 negative regulation of mesenchymal cell apoptotic process GO:2001054 9.55 GDF5 SOX9
36 extracellular matrix disassembly GO:0022617 9.55 ACAN MMP1 MMP13 MMP3 TIMP1
37 mesenchyme development GO:0060485 9.54 BMP2 BMP7
38 anterior head development GO:0097065 9.52 COL2A1 SOX9
39 monocyte aggregation GO:0070487 9.46 BMP7 IL1B
40 skeletal system development GO:0001501 9.43 ACAN BMP2 BMP7 COL2A1 COL9A2 SOX9
41 cartilage development GO:0051216 9.17 BMP2 BMP7 COL2A1 GDF5 MMP13 SOX9

Molecular functions related to Bone Deterioration Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.56 BMP2 BMP7 GDF5 TIMP1
2 metalloendopeptidase activity GO:0004222 9.54 MMP1 MMP13 MMP3
3 cytokine activity GO:0005125 9.35 BMP2 BMP7 GDF5 IL1B TIMP1
4 transforming growth factor beta receptor binding GO:0005160 9.33 BMP2 BMP7 GDF5
5 BMP receptor binding GO:0070700 9.32 BMP2 BMP7
6 extracellular matrix structural constituent conferring tensile strength GO:0030020 8.8 COL2A1 COL9A2 COL9A3

Sources for Bone Deterioration Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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