Bone Development Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Bone Development Disease

MalaCards integrated aliases for Bone Development Disease:

Name: Bone Development Disease ¹¹ ¹⁴ ¹⁶

Classifications:

MalaCards categories:
Global: Fetal diseases Rare diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0080006

EFO ¹⁶ EFO_0005541

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Summaries for Bone Development Disease

Disease Ontology: ¹¹ A bone disease that results in abnormal growth and development located in bone or located in cartilage.

MalaCards based summary: Bone Development Disease is related to shox-related short stature and dysostosis. An important gene associated with Bone Development Disease is RNU4ATAC (RNA, U4atac Small Nuclear), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Signaling by Receptor Tyrosine Kinases. Affiliated tissues include bone and cartilage, and related phenotypes are limbs/digits/tail and growth/size/body region

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Related Diseases for Bone Development Disease

Diseases in the Bone Development Disease family:

Rare Bone Development Disorder

Diseases related to Bone Development Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)

#	Related Disease	Score	Top Affiliating Genes
1	shox-related short stature	32.0	SLC26A2 SHOX
2	dysostosis	32.0	RUNX2 RNU4ATAC MSX2 IHH H2AC18 FGFR3
3	osteochondrodysplasia	31.6	SOX9 SLC26A2 SHOX RUNX2 RNU4ATAC P3H1
4	fibular aplasia or hypoplasia, femoral bowing and poly-, syn-, and oligodactyly	10.9
5	mandibuloacral dysplasia with type a lipodystrophy	10.9
6	spondylocarpotarsal synostosis syndrome	10.9
7	eiken syndrome	10.9
8	saul-wilson syndrome	10.9
9	asphyxiating thoracic dystrophy	10.9
10	vitamin d-dependent rickets	10.9
11	split hand-foot malformation	10.9
12	geleophysic dysplasia	10.9
13	otopalatodigital syndrome spectrum disorder	10.9
14	clubfoot	10.9
15	metaphyseal dysplasia	10.5	RUNX2 RNU4ATAC COL2A1
16	ehlers-danlos/osteogenesis imperfecta syndrome	10.5	COL1A2 COL1A1
17	osteogenesis imperfecta, type v	10.5	IFITM5 COL1A2 COL1A1
18	osteogenesis imperfecta, type vi	10.5	IFITM5 COL1A2 COL1A1
19	high bone mass osteogenesis imperfecta	10.5	COL1A2 COL1A1
20	osteogenesis imperfecta, type xi	10.5	CRTAP COL1A2 COL1A1
21	primary bone dysplasia	10.5	FGFR3 COL2A1 COL1A2 COL1A1
22	hypertelorism, microtia, facial clefting syndrome	10.5	MSX2 FGFR3 FGFR2
23	osteogenesis imperfecta, type xiv	10.5	P3H1 CRTAP COL1A2
24	achondroplasia, severe, with developmental delay and acanthosis nigricans	10.5	IHH FGFR3 FGFR2
25	osteogenesis imperfecta, type xix	10.5	P3H1 MIA2 CRTAP
26	acromesomelic dysplasia 1	10.5	SHOX FGFR3 COL2A1
27	fibrogenesis imperfecta ossium	10.5	P3H1 CRTAP COL1A2 COL1A1
28	hemifacial hyperplasia	10.5	FGFR3 FGFR2
29	localized scleroderma	10.5	H2AC18 COL1A2 COL1A1
30	metatropic dysplasia	10.5	SOX9 RUNX2 COL2A1
31	osteogenesis imperfecta, type ix	10.5	SLC26A2 P3H1 CRTAP
32	collagen disease	10.5	H2AC18 COL2A1 COL1A2 COL1A1
33	pigmentation disease	10.5	RNU4ATAC FGFR3 FGFR2
34	muenke syndrome	10.5	MSX2 FGFR3 FGFR2
35	hypochondrogenesis	10.5	SLC26A2 COMP COL2A1
36	ehlers-danlos syndrome, classic type, 1	10.5	P3H1 CRTAP COL1A2 COL1A1
37	ehlers-danlos syndrome, arthrochalasia type, 2	10.5	IFITM5 CRTAP COL1A2 COL1A1
38	plagiocephaly	10.5	FGFR3 FGFR2
39	achondrogenesis, type ii	10.5	SLC26A2 COMP COL2A1
40	metachondromatosis	10.5	SOX9 IHH COL2A1
41	acromesomelic dysplasia	10.5	SHOX IHH FGFR3 COL2A1
42	dentin dysplasia	10.5	MSX2 MIA2 COL1A2
43	breast scirrhous carcinoma	10.5	COL1A2 COL1A1
44	kniest dysplasia	10.5	SLC26A2 COMP COL2A1
45	epiphyseal dysplasia, multiple, 1	10.5	SLC26A2 MIA2 COMP COL1A1
46	stickler syndrome	10.5	SOX9 COL2A1 COL1A2 COL1A1
47	osteogenesis imperfecta, type vii	10.5	P3H1 IFITM5 CRTAP COL1A1
48	multiple epiphyseal dysplasia due to collagen 9 anomaly	10.5	SLC26A2 H2AC18 COMP
49	endosteal hyperostosis, autosomal dominant	10.5	SOX9 CRTAP COL1A2 COL1A1
50	multiple epiphyseal dysplasia	10.5	SLC26A2 COMP COL2A1

Graphical network of the top 20 diseases related to Bone Development Disease:

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Symptoms & Phenotypes for Bone Development Disease

MGI Mouse Phenotypes related to Bone Development Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail	MP:0005371	10.25	COL1A1 COL1A2 COL2A1 COMP FGFR2 FGFR3
2	growth/size/body region	MP:0005378	10.22	COL1A1 COL1A2 COL2A1 COMP CRTAP FGFR2
3	muscle	MP:0005369	10.09	COL1A1 COL1A2 COMP FGFR2 IHH MSX2
4	digestive/alimentary	MP:0005381	9.91	COL1A1 COL2A1 FGFR2 FGFR3 IHH MSX2
5	craniofacial	MP:0005382	9.9	COL1A1 COL2A1 FGFR2 FGFR3 IFITM5 IHH
6	hearing/vestibular/ear	MP:0005377	9.85	COL1A1 COL2A1 FGFR2 FGFR3 MSX2 SOX9
7	cellular	MP:0005384	9.73	CFAP47 COL1A1 COL1A2 COL2A1 COMP FGFR2
8	skeleton	MP:0005390	9.5	COL1A1 COL1A2 COL2A1 COMP CRTAP FGFR2

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Drugs & Therapeutics for Bone Development Disease

Search Clinical Trials, NIH Clinical Center for Bone Development Disease

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Genetic Tests for Bone Development Disease

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Anatomical Context for Bone Development Disease

Organs/tissues related to Bone Development Disease:

FMA: Bone, Cartilage

MalaCards : Bone

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Publications for Bone Development Disease

Articles related to Bone Development Disease:

#	Title	Authors	PMID	Year
1	Genome-wide screening of functional long noncoding RNAs in the epicardial adipose tissues of atrial fibrillation. ⁶²	Shi X...Zhang Y	32147422	2020
2	Fate of growth plate hypertrophic chondrocytes: death or lineage extension? ⁶²	Tsang KY...Cheah KS	25714187	2015
3	Bone tissue engineering with human stem cells. ⁶²	Marolt D...Novakovic GV	20637059	2010

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Genes for Bone Development Disease

Genes related to Bone Development Disease (0 elite genes):

(show top 50) (show all 74)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RNU4ATAC	RNA, U4atac Small Nuclear	RNA Gene	13.23	DISEASES inferred ¹⁴ ¹⁴
2	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	9.08	DISEASES inferred ¹⁴
3	CFAP47	Cilia And Flagella Associated Protein 47	Protein Coding	8.91	DISEASES inferred ¹⁴ ¹⁴ ¹⁴
4	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	8.88	DISEASES inferred ¹⁴
5	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	8.77	DISEASES inferred ¹⁴
6	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	8.72	DISEASES inferred ¹⁴
7	MIA2	MIA SH3 Domain ER Export Factor 2	Protein Coding	8.63	DISEASES inferred ¹⁴ ¹⁴
8	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	8.56	DISEASES inferred ¹⁴
9	COL2A1	Collagen Type II Alpha 1 Chain	Protein Coding	8.48	DISEASES inferred ¹⁴
10	H2AC18	H2A Clustered Histone 18	Protein Coding	8.34	DISEASES inferred ¹⁴ ¹⁴
11	CRTAP	Cartilage Associated Protein	Protein Coding	8.29	DISEASES inferred ¹⁴
12	SHOX	Short Stature Homeobox	Protein Coding	8.17	DISEASES inferred ¹⁴
13	SLC26A2	Solute Carrier Family 26 Member 2	Protein Coding	8.16	DISEASES inferred ¹⁴
14	SOX9	SRY-Box Transcription Factor 9	Protein Coding	8.16	DISEASES inferred ¹⁴
15	P3H1	Prolyl 3-Hydroxylase 1	Protein Coding	7.98	DISEASES inferred ¹⁴
16	IHH	Indian Hedgehog Signaling Molecule	Protein Coding	7.85	DISEASES inferred ¹⁴
17	MIR140	MicroRNA 140	RNA Gene	7.82	DISEASES inferred ¹⁴ ¹⁴
18	MSX2	Msh Homeobox 2	Protein Coding	7.82	DISEASES inferred ¹⁴
19	COMP	Cartilage Oligomeric Matrix Protein	Protein Coding	7.8	DISEASES inferred ¹⁴
20	IFITM5	Interferon Induced Transmembrane Protein 5	Protein Coding	7.76	DISEASES inferred ¹⁴
21	FKBP10	FKBP Prolyl Isomerase 10	Protein Coding	7.75	DISEASES inferred ¹⁴
22	FGFR1	Fibroblast Growth Factor Receptor 1	Protein Coding	7.73	DISEASES inferred ¹⁴
23	SP7	Sp7 Transcription Factor	Protein Coding	7.71	DISEASES inferred ¹⁴
24	GDF5	Growth Differentiation Factor 5	Protein Coding	7.7	DISEASES inferred ¹⁴
25	ACAN	Aggrecan	Protein Coding	7.68	DISEASES inferred ¹⁴
26	TRAPPC2	Trafficking Protein Particle Complex Subunit 2	Protein Coding	7.66	DISEASES inferred ¹⁴
27	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	7.63	DISEASES inferred ¹⁴
28	HOXD13	Homeobox D13	Protein Coding	7.59	DISEASES inferred ¹⁴
29	GLI3	GLI Family Zinc Finger 3	Protein Coding	7.58	DISEASES inferred ¹⁴
30	PTH	Parathyroid Hormone	Protein Coding	7.56	DISEASES inferred ¹⁴
31	COL9A2	Collagen Type IX Alpha 2 Chain	Protein Coding	7.52	DISEASES inferred ¹⁴
32	SOST	Sclerostin	Protein Coding	7.46	DISEASES inferred ¹⁴
33	CTSK	Cathepsin K	Protein Coding	7.44	DISEASES inferred ¹⁴
34	COL10A1	Collagen Type X Alpha 1 Chain	Protein Coding	7.43	DISEASES inferred ¹⁴
35	COL9A1	Collagen Type IX Alpha 1 Chain	Protein Coding	7.41	DISEASES inferred ¹⁴
36	ADAMTSL2	ADAMTS Like 2	Protein Coding	7.39	DISEASES inferred ¹⁴
37	SMARCAL1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A Like 1	Protein Coding	7.39	DISEASES inferred ¹⁴
38	NPPC	Natriuretic Peptide C	Protein Coding	7.36	DISEASES inferred ¹⁴
39	TWIST1	Twist Family BHLH Transcription Factor 1	Protein Coding	7.35	DISEASES inferred ¹⁴
40	BMP2	Bone Morphogenetic Protein 2	Protein Coding	7.34	DISEASES inferred ¹⁴
41	FBN1	Fibrillin 1	Protein Coding	7.34	DISEASES inferred ¹⁴
42	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	7.33	DISEASES inferred ¹⁴ ¹⁴
43	SHH	Sonic Hedgehog Signaling Molecule	Protein Coding	7.32	DISEASES inferred ¹⁴
44	TRAPPC2B	Trafficking Protein Particle Complex Subunit 2B	Protein Coding	7.32	DISEASES inferred ¹⁴
45	COL9A3	Collagen Type IX Alpha 3 Chain	Protein Coding	7.31	DISEASES inferred ¹⁴
46	IFT80	Intraflagellar Transport 80	Protein Coding	7.3	DISEASES inferred ¹⁴
47	EVC2	EvC Ciliary Complex Subunit 2	Protein Coding	7.3	DISEASES inferred ¹⁴
48	TMEM38B	Transmembrane Protein 38B	Protein Coding	7.26	DISEASES inferred ¹⁴
49	COL11A2	Collagen Type XI Alpha 2 Chain	Protein Coding	7.24	DISEASES inferred ¹⁴
50	FGF8	Fibroblast Growth Factor 8	Protein Coding	7.24	DISEASES inferred ¹⁴

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Variations for Bone Development Disease

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Expression for Bone Development Disease

Search GEO for disease gene expression data for Bone Development Disease.

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Pathways for Bone Development Disease

Pathways directly related to Bone Development Disease:

#	Pathway	Source
1	Signaling by FGFR in disease	Reactome ⁶⁶
2	Signaling by FGFR2 in disease	Reactome ⁶⁶
3	Signaling by FGFR3 in disease	Reactome ⁶⁶
4	Signaling by FGFR1 in disease	Reactome ⁶⁶
5	FGFR1 mutant receptor activation	Reactome ⁶⁶
6	Signaling by activated point mutants of FGFR1	Reactome ⁶⁶
7	FGFR2 mutant receptor activation	Reactome ⁶⁶
8	Signaling by activated point mutants of FGFR3	Reactome ⁶⁶
9	FGFR3 mutant receptor activation	Reactome ⁶⁶
10	Activated point mutants of FGFR2	Reactome ⁶⁶

Pathways related to Bone Development Disease according to GeneCards Suite gene sharing:

(show all 21)

#	Super pathways	Score	Top Affiliating Genes
1	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.78	FGFR3 FGFR2 COMP COL2A1 COL1A2 COL1A1
2	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.7	FGFR3 FGFR2 COL2A1 COL1A2 COL1A1
3	Collagen chain trimerization ⁶⁶ Show member pathways Anchoring fibril formation ⁶⁶ Assembly of collagen fibrils and other multimeric structures ⁶⁶ Blood Coagulation Cascade ⁶⁴ Collagen biosynthesis and modifying enzymes ⁶⁶ Collagen degradation ⁶⁶ Collagen formation ⁶⁶ Crosslinking of collagen fibrils ⁶⁶ Intrinsic Prothrombin Activation Pathway ⁶⁴	12.68	P3H1 CRTAP COL2A1 COL1A2 COL1A1
4	Extracellular matrix organization ⁶⁶ Show member pathways Degradation of the extracellular matrix ⁶⁶	12.55	P3H1 CRTAP COMP COL2A1 COL1A2 COL1A1
5	Focal adhesion ⁷⁴	12.14	COMP COL2A1 COL1A2 COL1A1
6	ECM proteoglycans ⁶⁶ Show member pathways Integrin cell surface interactions ⁶⁶ MED and pseudoachondroplasia genes ⁷⁴	12.03	COMP COL2A1 COL1A2 COL1A1
7	Endochondral ossification ⁷⁴ Show member pathways Endochondral ossification with skeletal dysplasias ⁷⁴	11.87	SOX9 RUNX2 IHH FGFR3 COL2A1
8	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	11.74	SOX9 RUNX2 MSX2 COL2A1
9	Neural crest differentiation ⁷⁴	11.66	SOX9 MSX2 FGFR3 FGFR2 COL2A1
10	Burn wound healing ⁷⁴	11.58	FGFR3 FGFR2 COL1A2 COL1A1
11	Cell adhesion_ECM remodeling ²²	11.53	COL1A1 COL1A2 COL2A1
12	RUNX2 regulates bone development ⁶⁶ Show member pathways RUNX2 regulates chondrocyte maturation ⁶⁶ RUNX2 regulates osteoblast differentiation ⁶⁶	11.52	COL1A1 IHH RUNX2
13	Integrins in angiogenesis ⁶¹	11.47	COL2A1 COL1A2 COL1A1
14	FGF signaling pathway ⁶¹	11.43	RUNX2 FGFR3 FGFR2
15	Osteoblast differentiation and related diseases ⁷⁴	11.35	SOX9 RUNX2 IHH FGFR3 FGFR2
16	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	11.21	COL1A1 COL1A2 IHH RUNX2
17	FGFR3 signaling in chondrocyte proliferation and terminal differentiation ⁷⁴	11.08	FGFR3 IHH SOX9
18	G-protein signaling_Rap2B regulation pathway ²²	10.89	FGFR3 FGFR2 COL2A1 COL1A2 COL1A1
19	Type I collagen synthesis in the context of osteogenesis imperfecta ⁷⁴	10.87	P3H1 IFITM5 CRTAP COL1A2 COL1A1
20	MAP3K1 role in promoting and blocking gonadal determination ⁷⁴	10.8	SOX9 FGFR2
21	Syndecan-1-mediated signaling events ⁶¹	10.5	FGFR3 FGFR2 COL2A1 COL1A2 COL1A1

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GO Terms for Bone Development Disease

Cellular components related to Bone Development Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	endoplasmic reticulum lumen	GO:0005788	9.96	P3H1 CRTAP COL2A1 COL1A2 COL1A1
2	extracellular matrix	GO:0031012	9.85	IHH COMP COL2A1 COL1A2 COL1A1
3	collagen-containing extracellular matrix	GO:0062023	9.73	P3H1 FGFR2 COMP COL2A1 COL1A2 COL1A1
4	collagen type I trimer	GO:0005584	8.92	COL1A2 COL1A1

Biological processes related to Bone Development Disease according to GeneCards Suite gene sharing:

(show all 30)

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of gene expression	GO:0010468	10.23	SOX9 RUNX2 IHH COMP COL2A1
2	osteoblast differentiation	GO:0001649	10.21	RUNX2 MSX2 IHH COL1A1
3	positive regulation of epithelial cell proliferation	GO:0050679	10.14	SOX9 RUNX2 IHH FGFR2
4	collagen fibril organization	GO:0030199	10.13	COL1A1 COL1A2 COL2A1 COMP CRTAP
5	endochondral ossification	GO:0001958	10.08	RUNX2 FGFR3 COL2A1 COL1A1
6	cellular response to BMP stimulus	GO:0071773	10.06	SOX9 RUNX2 COL2A1
7	positive regulation of mesenchymal cell proliferation	GO:0002053	10.03	SOX9 IHH FGFR2
8	chondrocyte differentiation	GO:0002062	10.02	SOX9 RUNX2 IHH FGFR3 COL2A1
9	chondrocyte proliferation	GO:0035988	10	IHH FGFR3 COMP
10	cartilage development	GO:0051216	10	SOX9 MSX2 IHH COMP COL2A1
11	odontogenesis	GO:0042476	9.99	COL1A2 FGFR2 MSX2
12	limb bud formation	GO:0060174	9.99	SOX9 FGFR2 COL2A1
13	positive regulation of chondrocyte proliferation	GO:1902732	9.95	SOX9 COMP
14	chondrocyte development	GO:0002063	9.95	SOX9 RUNX2 MSX2 COMP
15	bone trabecula formation	GO:0060346	9.94	MSX2 COL1A1
16	positive regulation of phospholipase activity	GO:0010518	9.94	FGFR3 FGFR2
17	otic vesicle formation	GO:0030916	9.93	FGFR2 SOX9
18	bone mineralization	GO:0030282	9.93	SOX9 IFITM5 FGFR3 FGFR2 COMP COL1A2
19	lacrimal gland development	GO:0032808	9.92	FGFR2 SOX9
20	anterior head development	GO:0097065	9.91	SOX9 COL2A1
21	chondrocyte differentiation involved in endochondral bone morphogenesis	GO:0003413	9.9	SOX9 IHH
22	skeletal system morphogenesis	GO:0048705	9.89	COL1A1 COL2A1 FGFR2 RUNX2
23	negative regulation of post-translational protein modification	GO:1901874	9.88	P3H1 CRTAP
24	endochondral bone growth	GO:0003416	9.87	COMP FGFR2 FGFR3 MSX2
25	bone morphogenesis	GO:0060349	9.86	MSX2 IFITM5 FGFR3 FGFR2 COMP
26	otic vesicle development	GO:0071599	9.79	SOX9 COL2A1
27	prostate gland morphogenesis	GO:0060512	9.74	SOX9 FGFR2
28	ossification	GO:0001503	9.7	COL1A1 COL2A1 COMP IHH MSX2 RUNX2
29	cellular response to endogenous stimulus	GO:0071495	9.55	FGFR2 FGFR3
30	skeletal system development	GO:0001501	9.55	SOX9 SHOX RUNX2 IHH FGFR3 COMP

Molecular functions related to Bone Development Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix structural constituent	GO:0005201	9.86	COMP COL2A1 COL1A2 COL1A1
2	extracellular matrix structural constituent conferring tensile strength	GO:0030020	9.63	COL2A1 COL1A2 COL1A1
3	fibroblast growth factor receptor activity	GO:0005007	9.26	FGFR3 FGFR2
4	platelet-derived growth factor binding	GO:0048407	9.1	COL2A1 COL1A2 COL1A1

Sources

Sources for Bone Development Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: BND014 MIFTS: 31	Bone Development Disease Categories: Bone diseases, Fetal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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