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MCID: BND020
MIFTS: 65

Bone Disease

Categories: Bone diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Bone Disease

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MalaCards integrated aliases for Bone Disease:

Name: Bone Disease 12 15 17
Bone Diseases 56 44 45 74
Disorder of Skeletal System 74
Skeletal Disorder 56
Skeletal Disease 12

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:0080001
MeSH 45 D001847
SNOMED-CT 69 76069003
ICD10 34 M89 M89.8 M89.9
Sources

Summaries for Bone Disease

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MedlinePlus : 44 Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly throughout your life. During childhood and your teens, your body adds new bone faster than it removes old bone. After about age 20, you can lose bone faster than you make bone. To have strong bones when you are young, and to prevent bone loss when you are older, you need to get enough calcium, vitamin D, and exercise. You should also avoid smoking and drinking too much alcohol. Bone diseases can make bones easy to break. Different kinds of bone problems include Low bone density and osteoporosis, which make your bones weak and more likely to break Osteogenesis imperfecta makes your bones brittle Paget's disease of bone makes them weak Bones can also develop cancer and infections Other bone diseases, which are caused by poor nutrition, genetics, or problems with the rate of bone growth or rebuilding NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Bone Disease, also known as bone diseases, is related to ischemic bone disease and osteopetrosis, and has symptoms including back pain, bone pain and sciatica. An important gene associated with Bone Disease is DANCR (Differentiation Antagonizing Non-Protein Coding RNA), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. The drugs AT-101 and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and prostate, and related phenotypes are cellular and growth/size/body region

Disease Ontology : 12 A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function.

Wikipedia : 77 Bone disease refers to the medical conditions which affect the... more...

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Related Diseases for Bone Disease

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Diseases related to Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 420)
# Related Disease Score Top Affiliating Genes
1 ischemic bone disease 33.8 ACP5 BGLAP PTH RUNX2 SOST TNFRSF11A
2 osteopetrosis 33.5 CTSK TNFRSF11A TNFSF11
3 paget disease of bone 5, juvenile-onset 33.1 CALCA TNFRSF11A TNFRSF11B TNFSF11
4 osteitis fibrosa 32.8 B2M BGLAP CALCA PTH
5 paget's disease of bone 32.7 B2M BGLAP CALCA TNFRSF11A TNFRSF11B TNFSF11
6 hypophosphatasia 32.2 ALPL ALPP RUNX2
7 arthropathy 32.2 B2M TNFRSF11B TNFSF11
8 bone inflammation disease 32.2 ACP5 BGLAP CTSK TNFRSF11B TNFSF11
9 osteonecrosis 32.1 ACP5 BGLAP PTH RUNX2 TNFRSF11B TNFSF11
10 primary hyperparathyroidism 32.1 ALPP BGLAP CALCA FGF23 PTH VDR
11 chronic kidney failure 32.0 B2M BGLAP CALCA FGF23 PTH TNFRSF11B
12 multicentric carpotarsal osteolysis syndrome 31.9 BGLAP CTSK TNFRSF11A TNFRSF11B TNFSF11
13 renal osteodystrophy 31.9 BGLAP CALCA FGF23 PTH SOST TNFRSF11B
14 osteopetrosis, autosomal recessive 7 31.8 TNFRSF11A TNFSF11
15 cleidocranial dysplasia 31.7 ALPL BGLAP RUNX2
16 hypophosphatasia, adult 31.7 ALPL BGLAP CALCA PTH
17 osteopetrosis, autosomal dominant 2 31.6 ACP5 BGLAP CTSK SOST TNFSF11
18 enchondromatosis, multiple, ollier type 31.4 ACP5 EXT1 EXT2
19 myeloma, multiple 31.3 B2M DKK1 FGFR3 TNFRSF11B TNFSF11
20 hyperparathyroidism 30.9 ACP5 BGLAP CALCA FGF23 PTH TNFRSF11B
21 kidney disease 30.7 B2M FGF23 PTH TNFRSF11B VDR
22 rickets 30.6 ALPL BGLAP FGF23 PTH VDR
23 uremia 30.6 B2M PTH TNFRSF11B VDR
24 osteomalacia 30.6 ALPL BGLAP CALCA FGF23 PTH VDR
25 bone remodeling disease 30.5 ACP5 BGLAP CALCA CTSK EXT1 EXT2
26 hypophosphatemia 30.5 BGLAP FGF23 PTH
27 parathyroid adenoma 30.4 BGLAP CALCA PTH VDR
28 idiopathic hypercalciuria 30.4 BGLAP TNFSF11 VDR
29 rheumatoid arthritis 30.4 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
30 endosteal hyperostosis, autosomal dominant 30.3 CTSK TNFRSF11B TNFSF11
31 osteomyelitis 30.2 ACP5 CTSK TNFSF11
32 fibrogenesis imperfecta ossium 30.2 CALCA PTH TNFRSF11B
33 hypoparathyroidism 30.2 ALPP BGLAP FGF23 PTH
34 bone resorption disease 30.2 ACP5 BGLAP CALCA CTSK DKK1 PTH
35 monoclonal gammopathy of uncertain significance 30.2 B2M DKK1 FGFR3
36 fibrous dysplasia 30.1 BGLAP CALCA FGF23
37 hyperostosis 30.1 FGF23 SOST TNFRSF11B
38 osteoporosis 30.1 ACP5 ALPL ALPP BGLAP CALCA CTSK
39 hyperphosphatemia 30.0 FGF23 PTH RUNX2 VDR
40 giant cell tumor 29.8 BGLAP CALCA CTSK TNFRSF11A TNFRSF11B TNFSF11
41 glucocorticoid-induced osteoporosis 29.7 ACP5 BGLAP CALCA DKK1 PTH RUNX2
42 polycystic bone disease 12.2
43 hypophosphatemic bone disease 12.1
44 brittle bone disorder 11.9
45 gorham's disease 11.8
46 col1a1/2-related osteogenesis imperfecta 11.3
47 cystic angiomatosis of bone, diffuse 11.2
48 hajdu-cheney syndrome 11.1
49 diaphanospondylodysostosis 11.1
50 inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1 11.1

Graphical network of the top 20 diseases related to Bone Disease:



Diseases related to Bone Disease
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Symptoms & Phenotypes for Bone Disease

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UMLS symptoms related to Bone Disease:


back pain, bone pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Bone Disease:

47 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.3 ALPL B2M CTSK DKK1 EXT1 FGFR3
2 growth/size/body region MP:0005378 10.3 ALPL B2M CTSK DKK1 EXT1 FGF23
3 craniofacial MP:0005382 10.25 ALPL CTSK DKK1 EXT1 FGFR3 PTH
4 homeostasis/metabolism MP:0005376 10.18 ALPL B2M CTSK DKK1 FGF23 FGFR3
5 hematopoietic system MP:0005397 10.17 ALPL B2M CTSK FGF23 FGFR3 PTH
6 digestive/alimentary MP:0005381 10.15 ALPL B2M CTSK EXT1 FGF23 FGFR3
7 endocrine/exocrine gland MP:0005379 10.13 ALPL B2M CTSK FGF23 PTH RUNX2
8 immune system MP:0005387 10.11 ALPL B2M CTSK FGF23 FGFR3 PTH
9 limbs/digits/tail MP:0005371 10.07 ALPL CTSK DKK1 EXT1 FGF23 FGFR3
10 mortality/aging MP:0010768 9.97 ALPL B2M DKK1 EXT1 EXT2 FGF23
11 integument MP:0010771 9.92 B2M EXT1 FGF23 FGFR3 RUNX2 TNFRSF11A
12 respiratory system MP:0005388 9.56 ALPL CTSK DKK1 FGF23 FGFR3 RUNX2
13 skeleton MP:0005390 9.47 ALPL CTSK DKK1 EXT1 EXT2 FGF23
Sources

Drugs & Therapeutics for Bone Disease

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Drugs for Bone Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1081)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
AT-101 Approved, Investigational Phase 4,Phase 3 90141-22-3, 652-67-5 12597
2
Nitric Oxide Approved Phase 4,Phase 3 10102-43-9 145068
3
Isosorbide Dinitrate Approved, Investigational Phase 4,Phase 3 87-33-2 6883
4
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
5
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
6
Parathyroid hormone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 9002-64-6
7
Emtricitabine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 143491-57-0 60877
8
Tenofovir Approved, Experimental, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 147127-20-6 464205
9
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 471-34-1
10
Alendronate Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 66376-36-1, 121268-17-5 2088
11
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
12
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 113775-47-6 5311068 68602
13
Norepinephrine Approved Phase 4,Phase 3,Not Applicable 51-41-2 439260
14
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 62-31-7, 51-61-6 681
15
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-28-2 5757
16
Polyestradiol phosphate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 28014-46-2
17
Medroxyprogesterone acetate Approved, Investigational Phase 4,Phase 3,Phase 1 71-58-9
18
Progesterone Approved, Vet_approved Phase 4,Phase 3,Not Applicable 57-83-0 5994
19
Etidronic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7414-83-7, 2809-21-4 3305
20
Risedronate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 105462-24-6 5245
21
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 83-43-2 6741
22
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 2921-57-5
23
Prednisolone Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 50-24-8 5755
24
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 302-25-0
25
Methadone Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 76-99-3 4095
26
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 93-14-1 3516
27
Thrombin Approved, Investigational Phase 4
28
Sevoflurane Approved, Vet_approved Phase 4,Not Applicable 28523-86-6 5206
29
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
30
Teriparatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52232-67-4 16133850
31
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 615258-40-7
32
Pioglitazone Approved, Investigational Phase 4,Not Applicable 111025-46-8 4829
33
Linagliptin Approved Phase 4 668270-12-0 10096344
34
Octreotide Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 83150-76-9 6400441 383414
35
Somatostatin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 38916-34-6, 51110-01-1 53481605
36
Pasireotide Approved Phase 4,Phase 3,Phase 2,Phase 1 396091-73-9 9941444
37
lanreotide Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 108736-35-2
38
Celecoxib Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 169590-42-5 2662
39
Etanercept Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 185243-69-0
40
Sulfasalazine Approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 599-79-1 5359476 5353980
41
Adalimumab Approved Phase 4,Phase 3,Phase 2,Not Applicable 331731-18-1 16219006
42
Mecasermin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 68562-41-4
43
Pamidronate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 40391-99-9 4674
44
Rifampicin Approved Phase 4,Phase 3,Early Phase 1 13292-46-1 5381226 5458213
45
Pyrazinamide Approved, Investigational Phase 4,Early Phase 1 98-96-4 1046
46
Ethambutol Approved Phase 4 74-55-5 14052 3279
47
Isoniazid Approved, Investigational Phase 4,Phase 3,Early Phase 1 54-85-3 3767
48
Infliximab Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 170277-31-3
49
Certolizumab pegol Approved Phase 4,Phase 3,Phase 2,Phase 1 428863-50-7
50
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable,Early Phase 1 50-23-7 5754

Interventional clinical trials:

(show top 50) (show all 4780)
# Name Status NCT ID Phase Drugs
1 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
2 Optimizing Treatment Programs for Chronic Kidney Disease-mineral and Bone Disorder and Malnutrition Unknown status NCT02005302 Phase 4 1,25(OH)2 Vitamin D3;Vitamin D2
3 Cholecalciferol Supplementation in Restless Leg Syndrome in Patients With Chronic Kidney Disease Unknown status NCT03063190 Phase 4 Vitamin D;Placebo Oral Tablet
4 Intravenous Paricalcitol in Chronic Hemodialysis Patients Unknown status NCT03023748 Phase 4 Intravenous Paricalcitol
5 A Prospective Study of the InterFuse T(tm), Unknown status NCT02678130 Phase 4
6 Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss Unknown status NCT02322099 Phase 4 Alendronate;Placebo;Tenofovir disoproxil
7 The Effect of Perioperative Lidocaine Intravenous Infusion on Postoperative Recovery After Spine Surgery. Unknown status NCT02762656 Phase 4 Lidocaine
8 The Effect of Dexmedetomidine Analgesia and Sedation in Minimally Invasive Spine Surgery Under Local Anesthesia Unknown status NCT02535273 Phase 4 Dexmedetomidine;Lidocaine;Low-dose Dexmedetomidine;Moderate-dose Dexmedetomidine;High-dose Dexmedetomidine;normal saline
9 Duloxetine as an Analgesic Agent in Patients Undergoing Elective Spine Surgery Unknown status NCT02535000 Phase 4 Duloxetine;Placebo
10 Efficacy and Safety of Brand Versus Generic Alendronate for Osteoporosis Treatment Unknown status NCT02371252 Phase 4 Generic alendronate
11 The Effect of Inactive and Active Vitamin D on Serum Sclerostin/dickkopf1 Levels Unknown status NCT01765010 Phase 4 Calcitriol;Alfacalcidol;Cholecalciferol;Placebo
12 Multi-centre Clinical Trial on Hormone Replacement Treatment in China Unknown status NCT01698164 Phase 4 estradiol plus MPA;Ximingting Tablet;estradiol plus progesterone
13 Efficacy and Safety Study of Risedronate, Cholecalciferol Combination Tablet in Patients With Osteoporosis Unknown status NCT01675297 Phase 4 Risedronate/Cholecalciferol combination;Risedronate
14 CERAMENTâ„¢|G - Bone Healing and Re-infection Prophylaxis Unknown status NCT02128256 Phase 4
15 Osteoporosis and Dental Implant Unknown status NCT00727493 Phase 4 alendronate once weekly 70mg;placebo
16 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
17 Alendronate in the Prevention of Collapse of Femoral Head in Non-Traumatic Osteonecrosis Unknown status NCT00265252 Phase 4 Alendronate
18 A Trial Comparing Single Intra-op Dose of Methadone Versus Placebo in Patients Undergoing Spine Surgery Unknown status NCT02206685 Phase 4 Methadone;Normal Saline
19 Effect of Human Thrombin With Gelatin Matrix on Perioperative Blood Loss in Scoliosis Surgery Unknown status NCT01451788 Phase 4
20 Pulmonary Mechanics During Minimally Invasive Repair of Pectus Excavatum Unknown status NCT01486953 Phase 4 Desflurane;Sevoflurane
21 Effects of Omega-3 Fatty Acids on Bone and Frailty Unknown status NCT00634686 Phase 4
22 Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo Unknown status NCT01945788 Phase 4 Teriparatide (rDNA origin)
23 Study Evaluating Denosumab on Bone and Vascular Metabolism in Osteoporotic Chronic Kidney Disease Unknown status NCT02792413 Phase 4 Denosumab;NaCl (placebo)
24 Effect of Evogliptin on Bone Metabolism in Human Unknown status NCT02587975 Phase 4 Evogliptin
25 A One-year Randomized Controlled Trial Evaluating the Impact of Pioglitazone Versus Linagliptin on Bone Turnover Markers Unknown status NCT02429232 Phase 4 Pioglitazone;Linagliptin
26 Phase IV Clinical Study of Pegylated Somatropin (PEG Somatropin) to Treat Growth Hormone Deficiency Children Unknown status NCT02314676 Phase 4
27 Pegylated Somatropin (PEG Somatropin) in the Treatment of Children With Growth Hormone Deficiency Unknown status NCT02976675 Phase 4
28 Clinical Study of Pegylated Somatropin to Treat Children Growth Hormone Deficiency Unknown status NCT02908958 Phase 4
29 Pasireotide LAR and Pegvisomant Study in Acromegaly Unknown status NCT02668172 Phase 4 Pasireotide LAR 60 mg;Pegvisomant
30 Dose Reduction of Etanercept in Patients With Ankylosing Spondylitis Unknown status NCT02638896 Phase 4 etanercept (Half-Dose);etanercept (Full-Dose);Sulfasalazine;Celecoxib
31 Etanercept Versus Adalimumab in the Treatment of Patients With Ankylosing Spondylitis. A Switch Study Unknown status NCT02489760 Phase 4
32 Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures Unknown status NCT01482858 Phase 4
33 Effects of Sandostatin LAR® in Acromegaly Unknown status NCT01424241 Phase 4 Sandostatin LAR
34 Combined Treatment With TNF Inhibitor and Pamidronate in AS Patients: Effect on the Radiographic Progression Unknown status NCT02313727 Phase 4 Pamidronate
35 The Optimal Duration of Preoperative Anti-tuberculosis Treatment of Spinal Tuberculosis Unknown status NCT02477852 Phase 4 Isoniazid;Rifampicin;Ethambutol;Pyrazinamide
36 Immunodeficiency in Cartilage-hair Hypoplasia: Sub-project on Safety of Vaccination Against Chickenpox Unknown status NCT02383797 Phase 4
37 Effects of Biological Treatment on Blood Pressure and Endothelial Function in Patients With Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis Unknown status NCT02132234 Phase 4 Etanercept;Adalimumab;Certolizumab;Infliximab
38 Assessment Of Gh-Igf-1 Axis In Children With Chronic Myelogenous Leukemia (CML) In Remission Unknown status NCT01901666 Phase 4 Growth Hormone
39 Changes of Left Ventricular Mass and Cardiac Function in Patients With Active Acromegaly During Treatment With the Growth Hormone Receptor Antagonist Pegvisomant Unknown status NCT00552851 Phase 4 pegvisomant
40 Heart Function in Rheumatoid Arthritis and Ankylosing Spondylitis Pre and Post-TNF Blocker Unknown status NCT01072058 Phase 4 TNF blockers (infliximab, adalimumab, etanercept)
41 Danish Multicenter Study of Adalimumab in Spondyloarthritis Unknown status NCT00477893 Phase 4 Adalimumab;Placebo
42 Adalimumab in Alleviating Inflammation in Patients With Axial Spondyloarthritis Unknown status NCT02634541 Phase 4 Adalimumab
43 Treatment of Axial Spondyloarthritis by Recombinant Human Tumor Necrosis Factor-α Receptor Ⅱ IgG Fc Fusion Protein Unknown status NCT02364479 Phase 4 etanercept;etanercept (half dose);placebo
44 Percutaneous HydroDiscectomy Compared to TESI for Radiculopathy Unknown status NCT02414698 Phase 4 TESI
45 Effect of Perioperative Glucocorticoid Replacement on Prognosis of Surgical Patients With Sellar Lesions Unknown status NCT02190994 Phase 4 Hydrocortisone;Prednisone
46 Protocol for H.P. Acthar Gel in Moderately to Severely Active Psoriatic Arthritis Unknown status NCT01939132 Phase 4 Open label H.P. Acthar Gel
47 Conservative Versus Aggressive Discectomy for Primary Disc Herniation With Radiculopathy Unknown status NCT01204008 Phase 4
48 Safety and Efficacy of Anti-Pandemic H1N1 Vaccination in Rheumatic Diseases Unknown status NCT01151644 Phase 4
49 Denosumab in Metabolic Bone Disease in Chronic Intestinal Failure Patients Completed NCT02853539 Phase 4 Denosumab
50 A Study of Ibandronate (Bondronat) in Participants With Metastatic Bone Disease Completed NCT02564107 Phase 4 Ibandronate

Search NIH Clinical Center for Bone Disease

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: bone diseases

Sources

Genetic Tests for Bone Disease

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Sources

Anatomical Context for Bone Disease

About this section

MalaCards organs/tissues related to Bone Disease:

42
Bone, Breast, Prostate, Kidney, Testes, Bone Marrow, Spinal Cord
Sources

Publications for Bone Disease

About this section

Articles related to Bone Disease:

(show top 50) (show all 2890)
# Title Authors Year
1
First-in-Human Phase I Study of MBC-11, a Novel Bone-Targeted Cytarabine-Etidronate Conjugate in Patients with Cancer-Induced Bone Disease. ( 30413669 )
2019
2
Thermal ablation to relieve pain from metastatic bone disease: a systematic review. ( 30627778 )
2019
3
Primary hyperparathyroid bone disease. ( 30629246 )
2019
4
Incidence of surgical interventions for metastatic bone disease in the extremities: a population-based cohort study. ( 30632859 )
2019
5
The prognosis and management of neuroendocrine neoplasms-related metastatic bone disease: lessons from clinical practice. ( 30635793 )
2019
6
Tumor-derived extracellular vesicles inhibit osteogenesis and exacerbate myeloma bone disease. ( 30662562 )
2019
7
Non-Viral Delivery System and Targeted Bone Disease Therapy. ( 30699924 )
2019
8
Senescent Cells in Early Vascular Ageing and Bone Disease of Chronic Kidney Disease-A Novel Target for Treatment. ( 30717151 )
2019
9
Has Paget's bone disease become rare? ( 30731129 )
2019
10
Myeloma bone disease: from biology findings to treatment approaches. ( 30760454 )
2019
11
Gorham-Stout Syndrome: A Phantom Bone Disease Treated With Bisphosphonates. ( 30801337 )
2019
12
Management of Post-transplant Hyperparathyroidism and Bone Disease. ( 30811012 )
2019
13
Evaluation of bone disease in patients with cystic fibrosis and end-stage lung disease. ( 30843951 )
2019
14
Prediction of survival after surgical management of femoral metastatic bone disease - A comparison of prognostic models. ( 30847272 )
2019
15
Dual Roles of the Mineral Metabolism Disorders Biomarkers in Prevalent Hemodilysis Patients: In Renal Bone Disease and in Vascular Calcification. ( 30867641 )
2019
16
Pain prevalence and treatment in patients with metastatic bone disease. ( 30867771 )
2019
17
Hyponatremia and metabolic bone disease in patients with epilepsy: A cross-sectional study. ( 30905745 )
2019
18
Bone scan index as metastatic bone disease quantifier and predictor of radium-223-dichloride biochemical response. ( 30908340 )
2019
19
Epigenetic-Based Mechanisms of Osteoblast Suppression in Multiple Myeloma Bone Disease. ( 30918921 )
2019
20
Metastatic bone disease: Pathogenesis and therapeutic options: Up-date on bone metastasis management. ( 30937279 )
2019
21
Metastatic bone disease from an occult renal primary. ( 30948394 )
2019
22
They are not alone - Cell System and Bone Disease. ( 30991056 )
2019
23
Radiographic and histological evidence of metabolic bone disease in gliding leaf frogs (Agalychnis spurrelli). ( 30997428 )
2019
24
A patent review of bisphosphonates in treating bone disease. ( 31023104 )
2019
25
Metabolic Bone Disease of Prematurity: Diagnosis and Management. ( 31032241 )
2019
26
Hypereosinophilia and severe bone disease in an African child: an unexpected diagnosis. ( 31036733 )
2019
27
Metabolic bone disease of prematurity: causes, recognition, prevention, treatment and long-term consequences. ( 31079069 )
2019
28
Novel functions of the primary cilium in bone disease and cancer. ( 31108028 )
2019
29
Incorporating the patient perspective in the study of rare bone disease: insights from the osteogenesis imperfecta community. ( 30191258 )
2019
30
Pharmacometrics and systems pharmacology for metabolic bone diseases. ( 30690761 )
2019
31
Preliminary results of biodistribution and dosimetric analysis of [68Ga]Ga-DOTAZOL: a new zoledronate-based bisphosphonate for PET/CT diagnosis of bone diseases. ( 30877560 )
2019
32
Drugs for the treatment of metabolic bone diseases. ( 30950086 )
2019
33
Focal and Osteosclerotic Bone Diseases. ( 31073747 )
2019
34
Are mTOR and Endoplasmic Reticulum Stress Pathway Genes Associated with Oral and Bone Diseases? ( 30205378 )
2019
35
Frailty is an independent risk factor for mortality, cardiovascular disease, bone disease and diabetes among aging adults with HIV. ( 30590451 )
2018
36
Bone disease in β thalassemia patients: past, present and future perspectives. ( 28987275 )
2018
37
Side effects of drugs for osteoporosis and metastatic bone disease. ( 30192026 )
2018
38
Using Mendelian Randomization to Decipher Mechanisms of Bone Disease. ( 30203249 )
2018
39
The effect of meals on bone turnover - a systematic review with focus on diabetic bone disease. ( 30234398 )
2018
40
A Cross-Sectional Study of Growth and Metabolic Bone Disease in a Pediatric Global Cohort Undergoing Chronic Hemodialysis. ( 30268401 )
2018
41
PET-MRI for the Study of Metabolic Bone Disease. ( 30284705 )
2018
42
Management of multiple myeloma bone disease: impact of treatment on renal function. ( 30285492 )
2018
43
Preventing and Repairing Myeloma Bone Disease by Combining Conventional Antiresorptive Treatment With a Bone Anabolic Agent in Murine Models. ( 30320927 )
2018
44
Risk factors analysis and prevention of metabolic bone disease of prematurity. ( 30334994 )
2018
45
Primary biliary cholangitis and bone disease. ( 30343712 )
2018
46
Myeloma Bone Disease: Update on Pathogenesis and Novel Treatment Strategies. ( 30355994 )
2018
47
Rate of cardiovascular, renal and bone disease and their major risks factors in HIV-infected individuals on antiretroviral therapy in Spain. ( 30389268 )
2018
48
Mineral and Bone Disease in Kidney Transplant Recipients. ( 30390201 )
2018
49
LIGHT/TNFSF14 as a New Biomarker of Bone Disease in Multiple Myeloma Patients Experiencing Therapeutic Regimens. ( 30405638 )
2018
50
Exosomes play a role in multiple myeloma bone disease and tumor development by targeting osteoclasts and osteoblasts. ( 30409995 )
2018
Sources

Variations for Bone Disease

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ClinVar genetic disease variations for Bone Disease:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CACNA1G NM_198382.2(CACNA1G): c.667_669delTTC (p.Phe223del) deletion Likely pathogenic rs730882202 GRCh38 Chromosome 17, 50571958: 50571960
2 CACNA1G NM_198382.2(CACNA1G): c.667_669delTTC (p.Phe223del) deletion Likely pathogenic rs730882202 GRCh37 Chromosome 17, 48649319: 48649321
3 SLC39A13 NM_152264.4(SLC39A13): c.398C> T (p.Thr133Met) single nucleotide variant Conflicting interpretations of pathogenicity rs140574574 GRCh37 Chromosome 11, 47433573: 47433573
4 SLC39A13 NM_152264.4(SLC39A13): c.398C> T (p.Thr133Met) single nucleotide variant Conflicting interpretations of pathogenicity rs140574574 GRCh38 Chromosome 11, 47412022: 47412022
5 46;XY;t(7;12)(q21.13;q24)dn Translocation Uncertain significance

Copy number variations for Bone Disease from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 43764 10 49062854 52062367 Duplication skeletal anomalies
Sources

Expression for Bone Disease

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Search GEO for disease gene expression data for Bone Disease.
Sources

Pathways for Bone Disease

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Pathways related to Bone Disease according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
RANK Signaling in Osteoclasts 65
Show member pathways
 12.25 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
2
Osteoclast differentiation 38
11.87 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
3
Parathyroid hormone synthesis, secretion and action 38
11.83 BGLAP FGF23 PTH RUNX2 SOST TNFSF11
4
Rheumatoid arthritis 38
11.69 ACP5 CTSK TNFRSF11A TNFSF11
5
Endochondral Ossification 1
11.52 ALPL FGFR3 PTH RUNX2
6
FGF signaling pathway 1
11.33 BGLAP FGF23 RUNX2
7
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 23
11.31 BGLAP PTH RUNX2 TNFSF11 VDR
8
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
10.88 BGLAP CALCA PTH RUNX2 TNFRSF11A TNFRSF11B
9
NOTCH1 regulation of human endothelial cell calcification 1
10.78 ALPL FGFR3
10
Osteoclast Signaling 1
10.76 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
11
Thiamine metabolism 38
10.71 ALPL ALPP
12
Osteoblast Signaling 1
10.5 BGLAP FGF23 PTH TNFRSF11B TNFSF11
13
Vitamin D Metabolism 1
10.49 PTH VDR
Sources

GO Terms for Bone Disease

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Cellular components related to Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ALPL B2M BGLAP CALCA CTSK DKK1
2 extracellular space GO:0005615 9.36 ALPL B2M BGLAP CALCA CTSK DKK1

Biological processes related to Bone Disease according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.96 B2M BGLAP PTH TNFRSF11B
2 cell-cell signaling GO:0007267 9.88 CALCA FGFR3 PTH TNFRSF11A
3 regulation of signaling receptor activity GO:0010469 9.85 CALCA DKK1 FGF23 PTH TNFRSF11B TNFSF11
4 osteoblast differentiation GO:0001649 9.81 ALPL BGLAP RUNX2
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.74 TNFRSF11A TNFRSF11B TNFSF11
6 monocyte chemotaxis GO:0002548 9.71 CALCA TNFRSF11A TNFSF11
7 osteoblast development GO:0002076 9.66 BGLAP RUNX2
8 positive regulation of bone resorption GO:0045780 9.65 TNFRSF11A TNFSF11
9 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.65 EXT1 EXT2
10 endochondral ossification GO:0001958 9.65 ALPL FGFR3 RUNX2
11 mammary gland alveolus development GO:0060749 9.64 TNFRSF11A TNFSF11
12 cellular calcium ion homeostasis GO:0006874 9.63 PTH VDR
13 regulation of osteoclast differentiation GO:0045670 9.62 BGLAP TNFSF11
14 negative regulation of bone resorption GO:0045779 9.62 CALCA TNFRSF11B
15 response to inorganic substance GO:0010035 9.61 BGLAP TNFRSF11B
16 response to magnesium ion GO:0032026 9.61 FGF23 TNFRSF11B
17 vitamin D metabolic process GO:0042359 9.6 FGF23 VDR
18 cellular response to vitamin D GO:0071305 9.59 BGLAP FGF23
19 cellular response to parathyroid hormone stimulus GO:0071374 9.58 FGF23 SOST
20 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.56 EXT1 EXT2
21 skeletal system development GO:0001501 9.56 ALPL BGLAP EXT1 FGFR3 PTH RUNX2
22 phosphate ion homeostasis GO:0055062 9.55 FGF23 PTH
23 TNFSF11-mediated signaling pathway GO:0071847 9.52 TNFRSF11A TNFSF11
24 bone mineralization GO:0030282 9.51 BGLAP FGFR3
25 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.49 FGF23 VDR
26 cellular polysaccharide biosynthetic process GO:0033692 9.46 EXT1 EXT2
27 bone resorption GO:0045453 9.46 ACP5 CTSK PTH TNFSF11
28 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.43 TNFRSF11A TNFSF11
29 response to vitamin D GO:0033280 9.43 ALPL BGLAP PTH
30 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.4 TNFRSF11A TNFSF11
31 negative regulation of ossification GO:0030279 9.32 DKK1 SOST
32 ossification GO:0001503 9.23 ACP5 BGLAP EXT1 EXT2 RUNX2 SOST
33 cell differentiation GO:0030154 10.03 EXT2 FGF23 RUNX2 TNFSF11 VDR

Molecular functions related to Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 alkaline phosphatase activity GO:0004035 9.26 ALPL ALPP
2 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.16 EXT1 EXT2
3 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 8.96 EXT1 EXT2
4 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 8.62 EXT1 EXT2
Sources

Sources for Bone Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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