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MCID: BND020
MIFTS: 60

Bone Disease

Categories: Bone diseases, Rare diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Bone Disease

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MalaCards integrated aliases for Bone Disease:

Name: Bone Disease 12 15 17
Bone Diseases 54 42 43 15 71
Disorder of Skeletal System 71
Skeletal Disorder 54
Skeletal Disease 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0080001
MeSH 43 D001847
SNOMED-CT 67 76069003
ICD10 32 M89 M89.8 M89.9
UMLS 71 C0005940 C0263661
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Summaries for Bone Disease

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MedlinePlus : 42 Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly throughout your life. During childhood and your teens, your body adds new bone faster than it removes old bone. After about age 20, you can lose bone faster than you make bone. To have strong bones when you are young, and to prevent bone loss when you are older, you need to get enough calcium, vitamin D, and exercise. You should also avoid smoking and drinking too much alcohol. Bone diseases can make bones easy to break. Different kinds of bone problems include Low bone density and osteoporosis, which make your bones weak and more likely to break Osteogenesis imperfecta makes your bones brittle Paget's disease of bone makes them weak Bones can also develop cancer and infections Other bone diseases, which are caused by poor nutrition, genetics, or problems with the rate of bone growth or rebuilding NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Bone Disease, also known as bone diseases, is related to ischemic bone disease and gorham's disease, and has symptoms including back pain, bone pain and sciatica. An important gene associated with Bone Disease is DANCR (Differentiation Antagonizing Non-Protein Coding RNA), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. The drugs Tocopherol and Alendronate have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and breast, and related phenotypes are cellular and growth/size/body region

Disease Ontology : 12 A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function.

Wikipedia : 74 Bone disease refers to the medical conditions which affect the... more...

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Related Diseases for Bone Disease

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Diseases in the Bone Disease family:

Trpv4-Related Bone Disorder

Diseases related to Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 789)
# Related Disease Score Top Affiliating Genes
1 ischemic bone disease 34.7 TNFSF11 TNFRSF11B TNFRSF11A SOST RUNX2 PTH
2 gorham's disease 34.1 TNFSF11 PTH CALCA
3 brittle bone disorder 34.1 TNFSF11 TNFRSF11B SOST RUNX2 PTH FGFR3
4 osteopetrosis 34.1 TNFSF11 TNFRSF11B TNFRSF11A CTSK CALCA BGLAP
5 paget disease of bone 5, juvenile-onset 34.1 TNFSF11 TNFRSF11B TNFRSF11A CALCA
6 osteitis fibrosa 33.5 PTH FGF23 CALCA BGLAP B2M
7 paget's disease of bone 33.3 VDR TNFSF11 TNFRSF11B TNFRSF11A SOST PTH
8 osteonecrosis 33.3 TNFSF11 TNFRSF11B RUNX2 PTH DKK1 BGLAP
9 renal osteodystrophy 33.0 VDR TNFSF11 TNFRSF11B SOST PTH FGF23
10 primary hyperparathyroidism 32.9 VDR TNFSF11 TNFRSF11B SOST PTH FGF23
11 arthropathy 32.9 TNFSF11 TNFRSF11B TNFRSF11A B2M ALPL
12 hypophosphatasia 32.9 RUNX2 PTH ALPP ALPL
13 chronic kidney disease 32.8 VDR TNFSF11 TNFRSF11B SOST RUNX2 PTH
14 odontochondrodysplasia 32.8 TNFSF11 SOST RUNX2 PTH FGFR3 CTSK
15 bone inflammation disease 32.6 TNFSF11 TNFRSF11B ACP5
16 hypophosphatasia, adult 32.5 ALPP ALPL
17 osteopetrosis, autosomal dominant 2 32.4 TNFSF11 BGLAP ACP5
18 cleidocranial dysplasia 32.4 RUNX2 BGLAP ALPP ALPL
19 bone development disease 32.2 SOST RUNX2 PTH FGFR3 CTSK BGLAP
20 bone resorption disease 32.2 VDR TNFSF11 TNFRSF11B TNFRSF11A SOST RUNX2
21 hyperparathyroidism 32.1 VDR TNFSF11 TNFRSF11B SOST PTH FGF23
22 osteomalacia 32.1 VDR TNFSF11 PTH FGF23 CALCA BGLAP
23 hypophosphatasia, childhood 32.1 ALPP ALPL
24 enchondromatosis, multiple, ollier type 32.0 RUNX2 PTH FGFR3 EXT2 EXT1 ACP5
25 mammary paget's disease 32.0 TNFSF11 TNFRSF11B TNFRSF11A PTH CTSK CALCA
26 myeloma, multiple 32.0 TNFSF11 TNFRSF11B SOST RUNX2 PTH FGFR3
27 kidney disease 31.9 VDR TNFRSF11B PTH FGF23 BGLAP B2M
28 bone remodeling disease 31.9 VDR TNFSF11 TNFRSF11B TNFRSF11A SOST RUNX2
29 osteopetrosis, autosomal recessive 2 31.8 TNFSF11 ACP5
30 secondary hyperparathyroidism 31.8 VDR TNFRSF11B PTH FGF23 CALCA BGLAP
31 rickets 31.8 VDR PTH FGF23 BGLAP ALPP ALPL
32 osteoporosis 31.7 VDR TNFSF11 TNFRSF11B TNFRSF11A SOST RUNX2
33 osteomyelitis 31.6 TNFSF11 CTSK CALCA ALPL ACP5
34 hypoparathyroidism 31.5 VDR PTH FGF23 CALCA BGLAP ALPP
35 hyperphosphatemia 31.5 VDR TNFRSF11B RUNX2 PTH FGF23 BGLAP
36 hypophosphatemia 31.5 VDR PTH FGF23 BGLAP ALPL
37 endosteal hyperostosis, autosomal dominant 31.4 TNFSF11 TNFRSF11B SOST PTH CTSK ACP5
38 uremia 31.4 VDR TNFRSF11B PTH B2M
39 hyperthyroidism 31.3 PTH CALCA BGLAP ALPP ACP5
40 fibrous dysplasia 31.3 RUNX2 FGF23 CALCA BGLAP
41 bone cancer 31.2 VDR TNFSF11 TNFRSF11B TNFRSF11A CALCA
42 parathyroid adenoma 31.2 VDR PTH CALCA BGLAP ALPP
43 nephrolithiasis, calcium oxalate 31.2 VDR PTH FGF23 CALCA BGLAP
44 monoclonal gammopathy of uncertain significance 31.1 TNFSF11 FGFR3 DKK1 B2M
45 osteogenic sarcoma 31.1 TNFSF11 TNFRSF11B RUNX2 PTH DANCR BGLAP
46 glucocorticoid-induced osteoporosis 31.1 VDR TNFSF11 TNFRSF11B SOST RUNX2 PTH
47 idiopathic hypercalciuria 31.1 VDR TNFSF11 BGLAP
48 sclerosteosis 31.1 VDR TNFSF11 TNFRSF11B SOST RUNX2 PTH
49 arthritis 31.0 TNFSF11 TNFRSF11A PTH CTSK ACP5
50 multicentric carpotarsal osteolysis syndrome 31.0 TNFSF11 TNFRSF11B TNFRSF11A BGLAP

Graphical network of the top 20 diseases related to Bone Disease:



Diseases related to Bone Disease
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Symptoms & Phenotypes for Bone Disease

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UMLS symptoms related to Bone Disease:


back pain, bone pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Bone Disease:

45 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.29 ALPL B2M CTSK DKK1 EXT1 FGFR3
2 growth/size/body region MP:0005378 10.28 ALPL B2M CTSK DKK1 EXT1 FGF23
3 craniofacial MP:0005382 10.24 ALPL CTSK DKK1 EXT1 FGFR3 PTH
4 hematopoietic system MP:0005397 10.14 ALPL B2M CTSK FGF23 FGFR3 PTH
5 digestive/alimentary MP:0005381 10.13 ALPL B2M CTSK EXT1 FGF23 FGFR3
6 limbs/digits/tail MP:0005371 10.13 ALPL CTSK DKK1 EXT1 FGF23 FGFR3
7 endocrine/exocrine gland MP:0005379 10.11 ALPL B2M CTSK FGF23 PTH RUNX2
8 immune system MP:0005387 10.11 ALPL B2M CTSK FGF23 FGFR3 PTH
9 mortality/aging MP:0010768 10.07 ALPL B2M DKK1 EXT1 EXT2 FGF23
10 reproductive system MP:0005389 9.81 ALPL B2M CTSK FGF23 FGFR3 RUNX2
11 respiratory system MP:0005388 9.56 ALPL CTSK DKK1 FGF23 FGFR3 RUNX2
12 skeleton MP:0005390 9.47 ALPL CTSK DKK1 EXT1 EXT2 FGF23
Sources

Drugs & Therapeutics for Bone Disease

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Drugs for Bone Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 398)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
2
Alendronate Approved Phase 4 66376-36-1, 121268-17-5 2088
3
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
4
Lactulose Approved Phase 4 4618-18-2 11333
5
Tibolone Approved, Investigational Phase 4 5630-53-5
6
Mecasermin Approved, Investigational Phase 4 68562-41-4
7
Potassium citrate Approved, Investigational, Vet_approved Phase 4
8
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
9
Gliclazide Approved Phase 4 21187-98-4 3475
10
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
11
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
12
Norelgestromin Approved, Investigational Phase 4 53016-31-2 13752005
13
Methyltestosterone Approved Phase 4 58-18-4 6010
14
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
15
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 6013 10204
16
Testosterone enanthate Approved Phase 4 315-37-7 9416
17
Cobicistat Approved Phase 4 1004316-88-4
18
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
19
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
20
Methadone Approved Phase 4 76-99-3 4095
21
Velpatasvir Approved, Investigational Phase 4 1377049-84-7 67683363
22
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
23
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
24
Acetaminophen Approved Phase 4 103-90-2 1983
25
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
26
Desogestrel Approved Phase 4 54024-22-5 40973
27
Abatacept Approved Phase 4 332348-12-6 10237
28
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
29
alemtuzumab Approved, Investigational Phase 4 216503-57-0
30
Promethazine Approved, Investigational Phase 4 60-87-7 4927
31
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
32
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
33
Mycophenolic acid Approved Phase 4 24280-93-1 446541
34
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
35
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
36
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
37 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
38
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
39
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
40
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
41
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
42
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
43
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
44
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
45
Calcitriol Approved, Nutraceutical Phase 4 32222-06-3 134070 5280453
46
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
47 Tocotrienol Investigational Phase 4 6829-55-6
48
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
49
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
50 Retinol palmitate Phase 4

Interventional clinical trials:

(show top 50) (show all 735)
# Name Status NCT ID Phase Drugs
1 Providing Intravenous Paricalcitol Treatment to the Sick and Poor Chronic Hemodialysis Patients With Severe Secondary Hyperparathyroidism Resistant to Existing Vitamin D Analogs Unknown status NCT03023748 Phase 4 Intravenous Paricalcitol
2 Study of Vitamin D2 Virus 1,25(OH)2-Vitamin D3 and Normal Protein Diet Virus Low Protein Diet in the Treatment of CKD-MBD and Malnutrition for Progressive CKD Patients Unknown status NCT02005302 Phase 4 1,25(OH)2 Vitamin D3;Vitamin D2
3 A Prospective Study of the InterFuse T(tm) Unknown status NCT02678130 Phase 4
4 Effects of Omega-3 Fatty Acids on Bone and Frailty Unknown status NCT00634686 Phase 4
5 Adverse Effects of Glucocorticoid Therapy on Bone in Childhood Crohn's Disease Unknown status NCT00609752 Phase 4 prednisolone
6 Maintenance of Vitamin D Sufficiency With Oral Vitamin D Supplementation in Malaysian Women of Malay and Indian Ethnicity With Post Menopausal Osteoporosis Unknown status NCT02389179 Phase 4 Vitamin D3
7 Study Comparing Full-dose Radiotherapy Versus Reduced Dose in the Management of Bone Metastasis in Patients With Breast Cancer Receiving Zoledronic Acid Completed NCT00172029 Phase 4 Zoledronic acid
8 An Open Label Study of the Efficacy, Safety, and Pharmacoeconomics of Oral Ibandronate (Bondronat 50 mg) in Treatment of Metastatic Bone Disease Completed NCT02564107 Phase 4 Ibandronate
9 Denosumab Counteracts Metabolic Bone Disease in Chronic Intestinal Failure Patients: A Randomized, Controlled Clinical Trial Completed NCT02853539 Phase 4 Denosumab
10 Osteopenia and Renal Osteodystrophy: Evaluation and Management Completed NCT00108394 Phase 4 pamidronate
11 Prospective, Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy of Disodium Pamidronate in the Treatment of Bone Loss Associated With Liver Transplant Completed NCT00657852 Phase 4 Disodium pamidronate;Placebo
12 Comparison Between Pamidronate and Zoledronic Acid for the Treatment of Heart and Lung Transplant Related Osteopaenia and Osteoporosis Completed NCT00164008 Phase 4 zoledronic acid vs pamidronate
13 Pilot Study: Effects of Hectorol (Doxercalciferol) Vitamin D Replacement on Proteinuria, PTH Level and Bone Turnover in Stable Kidney Transplant Recipients: a Single-Blind, Placebo-Controlled Study in Patients Receiving 25-OH Vitamin D3 Completed NCT00889629 Phase 4 Doxercalciferol;placebo;25-OH Vitamin D3
14 A Multicenter Study of the Efficacy of Cerezyme in Testing Skeletal Disease in Patients With Type I Gaucher Disease. Completed NCT00365131 Phase 4 Cerezyme (imiglucerase for injection)
15 An Open, Prospective, Multi-center Study to Evaluate Bone Loss, the Survival Rate of SPI Implant System and Implant Stability Over a 24 Months, in Patients With Tooth Loss Requiring up to 4 Implants, in Staged Loading Protocol. Completed NCT02367261 Phase 4
16 An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies Completed NCT00740129 Phase 4 Zoledronic Acid
17 A 2 Year Prospective, Multicentre, Open-label, Randomised, Controlled Study to Investigate the Effectiveness of Pamidronate in the Prevention of Bone Loss in de Novo Renal Transplant Patients (With a PTH > 150pg/ml) on a Ciclosporin A and Glucocorticoid Based Immunosuppressive Regimen. Completed NCT00738257 Phase 4 Pamidronate
18 A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China Completed NCT00774020 Phase 4 Zoledronic acid
19 A Multi-center, Post Marketing Surveillance Study to Monitor the Safety and Performance of the Barricaid® ARD in the Treatment of Back and Radicular Pain Caused by Primary Lumbar Disc Herniation Completed NCT01534065 Phase 4
20 Double-blind, Placebo-controlled, Randomized, Multicenter Study to Assess the Efficacy and Safety of Oral Ibandronate Once Monthly in Postmenopausal Women With Osteopenia Completed NCT00129623 Phase 4 Placebo;ibandronate [Bonviva/Boniva]
21 Influence of Alfacalcidol on Falls in Elderly Postmenopausal, Alendronate-Treated, Osteopenic/Osteoporotic Women With High Risk of Falls Completed NCT00168909 Phase 4 alfacalcidol;placebo
22 A Randomized, Double-Blind, Multicenter, Parallel Pilot Clinical Trial to Study the Efficay of a Treatment of Lactulose + Vitamin D + Calcium 0.5 g Concurrently Controlled With a Standard Treatment (Vit D + Calcium) in Bone Mass Preservation Among Postmenopausal Women Completed NCT00160264 Phase 4 Lactulose, Vitamin D, Calcium
23 An International Multicentric, Multidisciplinary Prospective and Randomized Study to Compare Minimally Invasive Reduction and Fixation Using the KyphX System and Radiopaque PMMA Cement to Medical Therapy Alone for the Treatment of Painful, Acute Osteopenic Vertebral Body Compression Fractures Completed NCT00211211 Phase 4
24 A Multi-center Study to Evaluate Bone Loss, Survival Rate and Stability of ICE Implant System Over 24 Months, for Patients With Tooth Loss Requiring up to 4 Implants, in Staged Loading Protocol Completed NCT01960361 Phase 4
25 A Prospective, Open-Label, Multi-Center, Two-Part Study to Investigate Patient Satisfaction With Monthly Dosed Ibandronate Therapy in Women With Post-Menopausal Osteoporosis or Osteopenia Transitioned From Once-Weekly Alendronate or Risendronate Completed NCT02604836 Phase 4 Ibandronate
26 Cholecalciferol Supplementation for Anemia and Mineral and Bone Disorder in Hemodialysis Patients (CHAMBER): A Multicenter, Double-blind, Randomized, Placebo-controlled Trial Completed NCT02214563 Phase 4
27 Study of Vitamin D2 Virus 1,25(OH)2-Vitamin D3 in the Treatment of Chronic Kidney Disease Mineral and Bone Disease Completed NCT01633853 Phase 4 Vitamin D2;1,25(OH)2 Vit D3
28 A Multinational, Randomized, Double-Blind, Parallel Group Comparative Trial on the Effects of 2 Years Treatment With Tibolone (1.25 mg Org OD 14) and Raloxifene (60 mg) on Bone Mineral Density in Osteopenic Postmenopausal Women Completed NCT00431431 Phase 4 tibolone;raloxifen
29 Can Risedronate Prevent Periprosthetic Bone Loss After Total Hip Arthroplasty. A Randomized, Double-blind, Placebo-controlled, Parallel-group Study Completed NCT00772395 Phase 4 Risedronate;Placebo
30 Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation Completed NCT00668200 Phase 4 Reclast (ZOL446, zoledronic acid)
31 An Open-Label, Multi-Center Study to Determine Level of Adherence to Monthly Oral or Every Three Month Intravenous Ibandronate Treatment in Post-Menopausal Women With Osteoporosis or Osteopenia, Who Are GI Intolerant of Daily or Weekly Alendronate or Risendronate Completed NCT02598453 Phase 4 Ibandronate
32 Switch From Tenofovir to Raltegravir for Low Bone Mineral Density Completed NCT00939874 Phase 4 Raltegravir
33 A Multicentre, Double-Blind, Randomized Placebo-Controlled Study of 70mg Alendronate Once Weekly for the Prevention and Treatment of Osteoporosis in Canadian Adult Cystic Fibrosis Patients Completed NCT00157690 Phase 4 Alendronate;Placebo
34 Do Aromatase Inhibitors (AIs) Decrease Intestinal Calcium Absorption? Completed NCT00766532 Phase 4 Aromatase Inhibitor
35 Alendronate Prevents Microarchitectural Deterioration of Trabecular Bone in Early Postmenopausal Completed NCT00504166 Phase 4 alendronate sodium
36 High Dosage Vitamin D in the Treatment of Osteoporosis in Postmenopausal Women Completed NCT00491920 Phase 4 cholecalciferol (Vitamin D3);placebo
37 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4 Alendronate;Pamidronate
38 NMR Imaging and Stereological Analysis of Trabecular Bone in Female Subjects 60 and Older at Risk of Fracture Receiving Either Zoledronic Acid or Teriparatide Completed NCT01153425 Phase 4 Teriparatide;Zoledronic Acid
39 Effect of Phosphate Binders on FGF-23 During Calcitriol Administration in CKD Stage 3 Patients Completed NCT01748396 Phase 4 Calcitriol;Calcium Carbonate
40 A Multicenter, Post-Approval Clinical Study for Asfotase Alfa (Human Recombinant Tissue-nonspecific Alkaline Phosphatase Fusion Protein) Treatment for Patients With Hypophosphatasia (HPP) in Japan Completed NCT02531867 Phase 4
41 Open-Label Study to Establish the Short Term Efficacy of Intravenous Loading-Doses of Bondronat 6 mg in Patients With Breast Cancer and Skeletal Metastases Experiencing Moderate to Severe Pain, Within 7 Days After Initiation of Treatment Completed NCT02553707 Phase 4 Ibandronate
42 Efficacy of Monthly Ibandronate in Women With Rheumatoid Arthritis and Reduced Bone Mineral Density Receiving Long-term Glucocorticoids Completed NCT01287533 Phase 4 Ibandronate;Placebo
43 Effect of Anti-diabetic Drugs on Bone Metabolism and Glycemic Variability.A Comparison Between Vildagliptin and Gliclazide MR Completed NCT01679899 Phase 4 Vildagliptin;Gliclazide MR
44 Primary Hyperparathyroidism: Does a Systematic Treatment Improve the Calcium- and Bone Metabolism After Successful Surgery? - Part I Completed NCT01222026 Phase 4 Strontium Ranelate + Ca/Vitamin-D;Placebo
45 A Randomized Placebo Controlled Double Blind Investigation of the Effects of Potassium Citrate on Bone Metabolism in Postmenopausal Osteopenia Completed NCT00357331 Phase 4 potassium citrate
46 A Randomized, Double-blind, Placebo-controlled, Phase IV Trial Evaluating the Palliative Benefit of Either Continuing Pamidronate or Switching to Second-line Zoledronic Acid in Breast Cancer Patients With High-risk Bone Metastases. Completed NCT01907880 Phase 4 Pamidronate;Zoledronic acid;placebo
47 An Open-label Trial on the Effect of I.V. Zoledronic Acid 4 mg on Bone Mineral Density in Hormone Sensitive Prostate Cancer Patients With Bone Metastasis Completed NCT00035997 Phase 4 Zometa
48 A Phase 4 Randomized Multicenter Open Label Trial of Paricalcitol Versus Calcitriol for Efficacy and Safety in Stage 3 or 4 Ckd Patients With Secondary Hyperparathyroidism Completed NCT00823303 Phase 4 Paricalcitol;Calcitriol
49 A Prospective and Randomized Trial of Zoledronic Acid to Prevent Bone Loss in the First Year After Kidney Transplantation Completed NCT01675089 Phase 4 Zoledronic acid
50 Effect of Varied Dialysate Bicarbonate Levels on Phosphate and Potassium Removal: A Pilot Study Completed NCT01930370 Phase 4 Bicarbonate hemodialysis solution (low concentration);Bicarbonate hemodialysis solution (high concentration)

Search NIH Clinical Center for Bone Disease

Inferred drug relations via UMLS 71 / NDF-RT 50 :


deferoxamine mesylate

Cochrane evidence based reviews: bone diseases

Sources

Genetic Tests for Bone Disease

About this section
Sources

Anatomical Context for Bone Disease

About this section

MalaCards organs/tissues related to Bone Disease:

40
Bone, Kidney, Breast, Prostate, Bone Marrow, Liver, Lung
Sources

Publications for Bone Disease

About this section

Articles related to Bone Disease:

(show top 50) (show all 13459)
# Title Authors PMID Year
1
Osteochondral Reconstruction of the Capitellum. 42
31739884 2020
2
Immediate versus conventional loading of mandibular implant-supported fixed prostheses in edentulous patients: 10-year report of a randomised controlled trial. 42
31781698 2019
3
Immediate versus conventional loading of variable-thread tapered implants supporting three- to four-unit fixed partial dentures in the posterior maxilla: 3-year results of a split-mouth randomised controlled trial. 42
31781699 2019
4
[Significance of sRANKL/OPG ratio in diagnosis of multiple myeloma bone disease]. 61 54
20416172 2010
5
The calcium-sensing receptor in bone cells: a potential therapeutic target in osteoporosis. 61 54
19660583 2010
6
The use of a point of care device for monitoring the bone resorption biomarker urinary N-telopeptide in cancer patients with bone metastases. 54 61
19931437 2010
7
Osteopontin: an effector and an effect of tumor metastasis. 54 61
20205680 2010
8
Runx2 association with progression of prostate cancer in patients: mechanisms mediating bone osteolysis and osteoblastic metastatic lesions. 61 54
19915614 2010
9
Extent of disease burden determined with magnetic resonance imaging of the bone marrow is predictive of survival outcome in patients with multiple myeloma. 54 61
19862816 2010
10
Theoretical investigation of the role of the RANK-RANKL-OPG system in bone remodeling. 54 61
19782692 2010
11
Bone biology and the role of the RANK ligand pathway. 61 54
20128323 2009
12
Serum levels of total-RANKL in multiple myeloma. 54 61
19951882 2009
13
Increased expression of macrophage inflammatory protein-1alpha on trephine biopsies correlates with extensive bone disease, increased angiogenesis and advanced stage in newly diagnosed patients with multiple myeloma. 61 54
19587705 2009
14
RUNX2 mutations in Chinese patients with cleidocranial dysplasia. 54 61
19515746 2009
15
Mechanism of bone metastasis: the role of osteoprotegerin and of the host-tissue microenvironment-related survival factors. 61 54
19201081 2009
16
The -9247 T/C polymorphism in the SOST upstream regulatory region that potentially affects C/EBPalpha and FOXA1 binding is associated with osteoporosis. 61 54
19371798 2009
17
RANKL inhibition for the management of patients with benign metabolic bone disorders. 61 54
19558335 2009
18
RANKL inhibition: clinical implications for the management of patients with multiple myeloma and solid tumors with bone metastases. 61 54
19344283 2009
19
Cathepsin K: a therapeutic target for bone diseases. 61 54
19338743 2009
20
Role of RANKL in bone diseases. 54 61
19185505 2009
21
RANK, RANKL and osteoprotegerin in bone biology and disease. 61 54
19468919 2009
22
Denosumab, a fully human monoclonal antibody to RANKL, inhibits bone resorption and increases BMD in knock-in mice that express chimeric (murine/human) RANKL. 61 54
19016581 2009
23
Proinflammatory cytokines and receptor activator of nuclear factor kappaB-ligand/osteoprotegerin associated with bone deterioration in patients with Crohn's disease. 61 54
19098682 2009
24
Clinical applications of RANK-ligand inhibition. 54 61
19356186 2009
25
Targeting Src signaling in metastatic bone disease. 54 61
18942061 2009
26
Bortezomib inhibits maturation and function of osteoclasts from PBMCs of patients with multiple myeloma by downregulating TRAF6. 61 54
18778854 2009
27
Emerging treatments for postmenopausal osteoporosis - focus on denosumab. 61 54
19554095 2009
28
Action of RANKL and OPG for osteoclastogenesis. 54 61
19191757 2009
29
1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression. 61 54
19449179 2009
30
Novel anti-cancer strategy in bone tumors by targeting molecular and cellular modulators of bone resorption. 61 54
18991786 2008
31
[Long-term steroid therapy in children: is adjunct therapy relevant in nephrotic syndrome?]. 54 61
18951767 2008
32
Negative regulation of the osteoblast function in multiple myeloma through the repressor gene E4BP4 activated by malignant plasma cells. 61 54
18829486 2008
33
Runx2 transcriptional activation of Indian Hedgehog and a downstream bone metastatic pathway in breast cancer cells. 61 54
18829534 2008
34
Vitamin D receptor ligand therapy in chronic kidney disease. 54 61
18826852 2008
35
RANKL inhibition in the treatment of bone metastases. 61 54
18685421 2008
36
Nutritional rickets and z scores for height in the United Arab Emirates: to D or not to D? 61 54
18937749 2008
37
Intracellular and surface RANKL are differentially regulated in patients with ankylosing spondylitis. 61 54
18369625 2008
38
Idiopathic severe elevation of serum alkaline phosphatase following adult renal transplantation: case reports. 61 54
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39
Current management of secondary hyperparathyroidism: a multicenter observational study (COSMOS). 61 54
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40
Skeletal deterioration induced by RANKL infusion: a model for high-turnover bone disease. 54 61
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41
Improvement of bone disease by imiglucerase (Cerezyme) therapy in patients with skeletal manifestations of type 1 Gaucher disease: results of a 48-month longitudinal cohort study. 61 54
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42
Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. 61 54
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43
Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. 54 61
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44
A case of lethal hypophosphatasia providing new insights into the perinatal benign form of hypophosphatasia and expression of the ALPL gene. 61 54
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45
Circulating cathepsin K and cystatin C in patients with cancer related bone disease: clinical and therapeutic implications. 61 54
17728092 2008
46
Bone disease drug discovery: examining the interactions between osteoblast and osteoclast. 61 54
18208371 2008
47
RANK ligand as a therapeutic target for bone metastases and multiple myeloma. 54 61
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48
Prognostic and predictive factors in patients with androgen-independent prostate cancer treated with docetaxel and estramustine: a single institution experience. 54 61
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49
Association between bone scintigraphy and serum levels of procollagen (I) and PSA in the detection of bone disease in prostate cancer patients. 54 61
18404790 2008
50
Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors. 54 61
17905588 2008
Sources

Variations for Bone Disease

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ClinVar genetic disease variations for Bone Disease:

6 ‎‎ ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CACNA1G NM_018896.5(CACNA1G):c.664_666TTC[1] (p.Phe223del)short repeat Likely pathogenic 183285 rs730882202 17:48649319-48649321 17:50571958-50571960
2 SLC39A13 NM_001128225.3(SLC39A13):c.398C>T (p.Thr133Met)SNV Conflicting interpretations of pathogenicity 196579 rs140574574 11:47433573-47433573 11:47412022-47412022
3 46;XY;t(7;12)(q21.13;q24)dnTranslocation Uncertain significance 267805

Copy number variations for Bone Disease from CNVD:

7
# CNVD ID Chromosome Start End Type Gene Symbol CNVD Disease
1 43764 10 49062854 52062367 Duplication skeletal anomalies
Sources

Expression for Bone Disease

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Search GEO for disease gene expression data for Bone Disease.
Sources

Pathways for Bone Disease

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Pathways related to Bone Disease according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
RANK Signaling in Osteoclasts 63
Show member pathways
 12.25 TNFSF11 TNFRSF11B TNFRSF11A CTSK ACP5
2
Osteoclast differentiation 36
11.91 TNFSF11 TNFRSF11B TNFRSF11A CTSK ACP5
3
Parathyroid hormone synthesis, secretion and action 36
11.83 VDR TNFSF11 SOST RUNX2 PTH FGF23
4
Rheumatoid arthritis 36
11.73 TNFSF11 TNFRSF11A PTH CTSK ACP5
5
Endochondral Ossification 1
11.55 RUNX2 PTH FGFR3 ALPL
6
FGF signaling pathway 1
11.33 RUNX2 FGF23 BGLAP
7
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
11.31 VDR TNFSF11 RUNX2 PTH BGLAP
8
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.88 VDR TNFSF11 TNFRSF11B TNFRSF11A RUNX2 PTH
9
NOTCH1 regulation of human endothelial cell calcification 1
10.78 FGFR3 ALPL
10
Osteoclast Signaling 1
10.76 TNFSF11 TNFRSF11B TNFRSF11A CTSK ACP5
11
Thiamine metabolism 36
10.71 ALPP ALPL
12
Osteoblast Signaling 1
10.5 TNFSF11 TNFRSF11B PTH FGF23 BGLAP
13
Vitamin D Metabolism 1
10.49 VDR PTH
Sources

GO Terms for Bone Disease

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Cellular components related to Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 TNFSF11 TNFRSF11B SOST PTH FGFR3 FGF23
2 extracellular space GO:0005615 9.36 TNFSF11 TNFRSF11B SOST PTH FGF23 DKK1

Biological processes related to Bone Disease according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.87 TNFRSF11A PTH FGFR3 CALCA
2 osteoblast differentiation GO:0001649 9.8 RUNX2 BGLAP ALPL
3 monocyte chemotaxis GO:0002548 9.69 TNFSF11 TNFRSF11A CALCA
4 heparan sulfate proteoglycan biosynthetic process GO:0015012 9.63 EXT2 EXT1
5 endochondral ossification GO:0001958 9.63 RUNX2 FGFR3 ALPL
6 mammary gland alveolus development GO:0060749 9.62 TNFSF11 TNFRSF11A
7 regulation of osteoclast differentiation GO:0045670 9.61 TNFSF11 BGLAP
8 cellular response to vitamin D GO:0071305 9.61 FGF23 BGLAP
9 negative regulation of bone resorption GO:0045779 9.6 TNFRSF11B CALCA
10 response to inorganic substance GO:0010035 9.59 TNFRSF11B BGLAP
11 vitamin D metabolic process GO:0042359 9.58 VDR FGF23
12 response to magnesium ion GO:0032026 9.58 TNFRSF11B FGF23
13 modulation of age-related behavioral decline GO:0090647 9.56 DKK1 B2M
14 skeletal system development GO:0001501 9.56 VDR TNFRSF11B RUNX2 PTH FGFR3 EXT1
15 cellular response to parathyroid hormone stimulus GO:0071374 9.55 SOST FGF23
16 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process GO:0015014 9.54 EXT2 EXT1
17 phosphate ion homeostasis GO:0055062 9.52 PTH FGF23
18 negative regulation of ossification GO:0030279 9.5 SOST DKK1 CALCA
19 TNFSF11-mediated signaling pathway GO:0071847 9.49 TNFSF11 TNFRSF11A
20 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.48 VDR FGF23
21 bone resorption GO:0045453 9.46 TNFSF11 PTH CTSK ACP5
22 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.43 TNFSF11 TNFRSF11A
23 response to vitamin D GO:0033280 9.43 PTH BGLAP ALPL
24 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.4 TNFSF11 TNFRSF11A
25 cellular polysaccharide biosynthetic process GO:0033692 9.37 EXT2 EXT1
26 ossification GO:0001503 9.23 TNFSF11 TNFRSF11A SOST RUNX2 EXT2 EXT1

Molecular functions related to Bone Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heparan sulfate N-acetylglucosaminyltransferase activity GO:0042328 9.26 EXT2 EXT1
2 alkaline phosphatase activity GO:0004035 9.16 ALPP ALPL
3 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity GO:0050508 8.96 EXT2 EXT1
4 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity GO:0050509 8.62 EXT2 EXT1
Sources

Sources for Bone Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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