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MCID: BND020
MIFTS: 60

Bone Disease

Categories: Bone diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Bone Disease

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MalaCards integrated aliases for Bone Disease:

Name: Bone Disease 12 15 17
Bone Diseases 55 43 44 15 72
Disorder of Skeletal System 72
Skeletal Disorder 55
Skeletal Disease 12

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:0080001
MeSH 44 D001847
SNOMED-CT 68 76069003
ICD10 33 M89 M89.8 M89.9
UMLS 72 C0005940 C0263661
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Summaries for Bone Disease

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MedlinePlus : 43 Your bones help you move, give you shape and support your body. They are living tissues that rebuild constantly throughout your life. During childhood and your teens, your body adds new bone faster than it removes old bone. After about age 20, you can lose bone faster than you make bone. To have strong bones when you are young, and to prevent bone loss when you are older, you need to get enough calcium, vitamin D, and exercise. You should also avoid smoking and drinking too much alcohol. Bone diseases can make bones easy to break. Different kinds of bone problems include Low bone density and osteoporosis, which make your bones weak and more likely to break Osteogenesis imperfecta makes your bones brittle Paget's disease of bone makes them weak Bones can also develop cancer and infections Other bone diseases, which are caused by poor nutrition, genetics, or problems with the rate of bone growth or rebuilding NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Bone Disease, also known as bone diseases, is related to ischemic bone disease and osteopetrosis, and has symptoms including back pain, bone pain and sciatica. An important gene associated with Bone Disease is DANCR (Differentiation Antagonizing Non-Protein Coding RNA), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. The drugs Isosorbide Dinitrate and AT-101 have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and breast, and related phenotypes are cellular and growth/size/body region

Disease Ontology : 12 A connective tissue disease that affects the structure or development of bone or causes an impairment of normal bone function.

Wikipedia : 75 Bone disease refers to the medical conditions which affect the... more...

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Related Diseases for Bone Disease

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Diseases related to Bone Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 769, show less)
# Related Disease Score Top Affiliating Genes
1 ischemic bone disease 34.4 TNFSF11 TNFRSF11B TNFRSF11A SOST RUNX2 PTH
2 osteopetrosis 34.2 TNFSF11 TNFRSF11A CTSK
3 paget disease of bone 5, juvenile-onset 34.1 TNFSF11 TNFRSF11B TNFRSF11A CALCA
4 osteitis fibrosa 33.5 PTH CALCA BGLAP B2M
5 paget's disease of bone 33.3 TNFSF11 TNFRSF11B TNFRSF11A CALCA BGLAP B2M
6 osteonecrosis 33.2 TNFSF11 TNFRSF11B RUNX2 PTH BGLAP ACP5
7 bone inflammation disease 33.0 TNFSF11 TNFRSF11B CTSK BGLAP ACP5
8 hypophosphatasia 33.0 RUNX2 ALPP ALPL
9 arthropathy 32.9 TNFSF11 TNFRSF11B B2M
10 hypophosphatasia, adult 32.9 PTH CALCA BGLAP ALPL
11 primary hyperparathyroidism 32.7 VDR PTH FGF23 CALCA BGLAP ALPP
12 renal osteodystrophy 32.7 VDR TNFRSF11B SOST PTH FGF23 CALCA
13 cleidocranial dysplasia 32.4 RUNX2 BGLAP ALPL
14 osteopetrosis, autosomal recessive 7 32.4 TNFSF11 TNFRSF11A
15 osteopetrosis, autosomal dominant 2 32.3 TNFSF11 SOST CTSK BGLAP ACP5
16 osteomalacia 32.0 VDR PTH FGF23 CALCA BGLAP ALPL
17 enchondromatosis, multiple, ollier type 32.0 EXT2 EXT1 ACP5
18 myeloma, multiple 32.0 TNFSF11 TNFRSF11B FGFR3 DKK1 B2M
19 hyperparathyroidism 31.9 VDR TNFRSF11B PTH FGF23 CALCA BGLAP
20 rickets 31.7 VDR PTH FGF23 BGLAP ALPL
21 osteomyelitis 31.5 TNFSF11 CTSK ACP5
22 endosteal hyperostosis, autosomal dominant 31.5 TNFSF11 TNFRSF11B CTSK
23 kidney disease 31.5 VDR TNFRSF11B PTH FGF23 B2M
24 hypoparathyroidism 31.5 PTH FGF23 BGLAP ALPP
25 hypophosphatemia 31.4 PTH FGF23 BGLAP
26 hyperphosphatemia 31.4 VDR RUNX2 PTH FGF23
27 bone resorption disease 31.4 VDR TNFSF11 TNFRSF11B TNFRSF11A SOST RUNX2
28 uremia 31.3 VDR TNFRSF11B PTH B2M
29 fibrous dysplasia 31.3 FGF23 CALCA BGLAP
30 parathyroid adenoma 31.2 VDR PTH CALCA BGLAP
31 idiopathic hypercalciuria 31.2 VDR TNFSF11 BGLAP
32 hyperostosis 31.1 TNFRSF11B SOST FGF23
33 monoclonal gammopathy of uncertain significance 31.1 FGFR3 DKK1 B2M
34 familial expansile osteolysis 31.1 TNFSF11 TNFRSF11B TNFRSF11A
35 sclerosteosis 31.0 VDR SOST RUNX2
36 multicentric carpotarsal osteolysis syndrome 31.0 TNFSF11 TNFRSF11B TNFRSF11A CTSK BGLAP
37 glucocorticoid-induced osteoporosis 30.8 TNFSF11 TNFRSF11B RUNX2 PTH DKK1 CALCA
38 hypercalcemia, infantile, 1 30.8 VDR PTH CALCA
39 periodontitis 30.8 TNFSF11 TNFRSF11B RUNX2 CTSK BGLAP
40 giant cell tumor 30.8 TNFSF11 TNFRSF11B TNFRSF11A CTSK CALCA BGLAP
41 ankylosis 30.8 TNFRSF11B RUNX2 BGLAP
42 fibrogenesis imperfecta ossium 30.7 TNFRSF11B PTH CALCA
43 osteoporosis, juvenile 30.7 SOST PTH DKK1 CALCA BGLAP
44 rheumatoid arthritis 30.7 TNFSF11 TNFRSF11B TNFRSF11A CTSK ACP5
45 bone remodeling disease 30.6 VDR TNFSF11 TNFRSF11B TNFRSF11A SOST RUNX2
46 calciphylaxis 30.6 VDR PTH FGF23
47 aneurysmal bone cysts 30.6 TNFSF11 TNFRSF11A CALCA
48 osteogenesis imperfecta, type i 30.5 TNFRSF11B FGFR3 BGLAP
49 pfeiffer syndrome 30.5 RUNX2 FGFR3 BGLAP ALPL
50 bone giant cell tumor 30.5 TNFSF11 CTSK CALCA ACP5
51 osteoporosis 30.5 VDR TNFSF11 TNFRSF11B TNFRSF11A SOST RUNX2
52 hypervitaminosis d 30.4 VDR PTH FGF23
53 periostitis 30.3 TNFRSF11A ALPP
54 exostosis 30.1 EXT2 EXT1 BGLAP
55 breast adenocarcinoma 29.9 TNFSF11 CTSK CALCA
56 polycystic bone disease 12.2
57 hypophosphatemic bone disease 12.2
58 rare genetic bone disease 12.2
59 pierre robin syndrome associated with bone disease 12.1
60 obsolete: rare bone disease with limb reduction defect 12.1
61 non-rare bone disease 12.0
62 rare bone disease related to a common gene or pathway defect 12.0
63 obsolete: bone disease with increased bone density and metaphyseal or diaphyseal involvement 12.0
64 brittle bone disorder 12.0
65 gorham's disease 11.9
66 col1a1/2-related osteogenesis imperfecta 11.4
67 cystic angiomatosis of bone, diffuse 11.3
68 thanatophoric dysplasia, type i 11.3
69 diaphanospondylodysostosis 11.3
70 hajdu-cheney syndrome 11.2
71 chronic kidney disease 11.2
72 inclusion body myopathy with early-onset paget disease with or without frontotemporal dementia 1 11.2
73 end stage renal failure 11.1
74 gaucher's disease 11.1
75 osteonecrosis of the jaw 11.1
76 gaucher disease, type i 11.1
77 odontochondrodysplasia 11.1
78 exostoses, multiple, type ii 11.1
79 exostoses, multiple, type i 11.1
80 diastrophic dysplasia 11.1
81 atelosteogenesis, type ii 11.1
82 achondrogenesis, type ib 11.1
83 bent bone dysplasia syndrome 11.1
84 coxa vara 11.1
85 hypophosphatasia, infantile 11.0
86 premature ovarian failure 1 11.0
87 dysbaric osteonecrosis 11.0
88 spinal stenosis 11.0
89 osteochondrosis 11.0
90 acrocapitofemoral dysplasia 11.0
91 inclusion body myopathy with early-onset paget disease and frontotemporal dementia 11.0
92 polyarticular onset juvenile idiopathic arthritis 11.0 TNFSF11 TNFRSF11B TNFRSF11A
93 hemophilic arthropathy 11.0 TNFSF11 TNFRSF11B TNFRSF11A
94 mesomelic dysplasia, kantaputra type 10.9
95 axial osteomalacia 10.9 PTH BGLAP
96 periapical periodontitis 10.9 TNFSF11 TNFRSF11B TNFRSF11A ACP5
97 lateral meningocele syndrome 10.9
98 metachondromatosis 10.9
99 metatropic dysplasia 10.9
100 kummell's disease 10.9 TNFSF11 TNFRSF11B SOST DKK1
101 extraskeletal chondroma 10.9 PTH BGLAP
102 hyperparathyroidism, transient neonatal 10.9
103 multicentric reticulohistiocytosis 10.9 TNFSF11 TNFRSF11B
104 breast leiomyosarcoma 10.9 TNFSF11 TNFRSF11A
105 villonodular synovitis 10.9 TNFSF11 ACP5
106 osseous heteroplasia, progressive 10.8 RUNX2 BGLAP ALPP
107 chronic apical periodontitis 10.8 TNFSF11 TNFRSF11B
108 tooth resorption 10.8 TNFSF11 TNFRSF11B TNFRSF11A CTSK ACP5
109 phosphorus metabolism disease 10.8 VDR PTH FGF23
110 periodontitis, chronic 10.8 TNFSF11 TNFRSF11B
111 aortic valve disease 2 10.8 TNFSF11 TNFRSF11B RUNX2
112 hypercementosis 10.8 TNFRSF11A SOST CTSK ACP5
113 mineral metabolism disease 10.8 VDR PTH FGF23 CALCA
114 hypocalcemia, autosomal dominant 1 10.8 VDR PTH FGF23 CALCA
115 impaired renal function disease 10.8 SOST PTH FGF23 BGLAP
116 cloacogenic carcinoma 10.8 PTH CALCA B2M
117 metaphyseal chondrodysplasia, jansen type 10.8 PTH FGFR3 FGF23 CALCA
118 basilar impression, primary 10.8
119 kyphomelic dysplasia 10.8
120 geleophysic dysplasia 3 10.8
121 trichorhinophalangeal syndrome, type i 10.8 TNFRSF11B RUNX2 EXT1
122 parathyroid gland disease 10.8 VDR PTH FGF23 CALCA BGLAP
123 anemia, congenital dyserythropoietic, type iii 10.8
124 brachyolmia type 3 10.8
125 klippel-feil syndrome 1, autosomal dominant 10.8
126 cleidorhizomelic syndrome 10.8
127 epiphyseal dysplasia, multiple, 1 10.8
128 chromosome 8q22.1 duplication syndrome 10.8
129 kniest dysplasia 10.8
130 spondyloepiphyseal dysplasia congenita 10.8
131 achondrogenesis, type ii 10.8
132 chondrodysplasia, grebe type 10.8
133 klippel-feil syndrome 2, autosomal recessive 10.8
134 mucopolysaccharidosis, type iva 10.8
135 osteopetrosis, autosomal recessive 2 10.8
136 osteopetrosis, autosomal recessive 5 10.8
137 osteopetrosis, autosomal recessive 3 10.8
138 spondylocostal dysostosis 1, autosomal recessive 10.8
139 winchester syndrome 10.8
140 spondyloepiphyseal dysplasia tarda, x-linked 10.8
141 epiphyseal dysplasia, multiple, 2 10.8
142 spondylospinal thoracic dysostosis 10.8
143 acromesomelic dysplasia, maroteaux type 10.8
144 intervertebral disc disease 10.8
145 osteopetrosis, autosomal dominant 1 10.8
146 acromesomelic dysplasia, demirhan type 10.8
147 osteopetrosis, autosomal recessive 4 10.8
148 osteopetrosis, autosomal recessive 6 10.8
149 klippel-feil syndrome 3, autosomal dominant 10.8
150 klippel-feil syndrome 4, autosomal recessive, with nemaline myopathy and facial dysmorphism 10.8
151 spondyloepimetaphyseal dysplasia, faden-alkuraya type 10.8
152 spondyloepimetaphyseal dysplasia, di rocco type 10.8
153 spondyloepimetaphyseal dysplasia, krakow type 10.8
154 acromesomelic dysplasia 10.8
155 root resorption 10.8 TNFSF11 TNFRSF11B TNFRSF11A RUNX2 CTSK CALCA
156 saethre-chotzen syndrome 10.7 RUNX2 FGFR3 BGLAP ALPP
157 ischiocoxopodopatellar syndrome with or without pulmonary arterial hypertension 10.7
158 paget disease of bone 3 10.7
159 parastremmatic dwarfism 10.7
160 spondyloepimetaphyseal dysplasia, strudwick type 10.7
161 spondylometaphyseal dysplasia, kozlowski type 10.7
162 multiple synostoses syndrome 1 10.7
163 hypophosphatemic rickets, autosomal dominant 10.7
164 hypophosphatasia, childhood 10.7
165 opsismodysplasia 10.7
166 spondyloepimetaphyseal dysplasia with joint laxity, type 1, with or without fractures 10.7
167 spondylometaepiphyseal dysplasia, short limb-hand type 10.7
168 spondyloepimetaphyseal dysplasia, x-linked 10.7
169 paget disease of bone 2, early-onset 10.7
170 spondyloepimetaphyseal dysplasia, missouri type 10.7
171 renal tubular acidosis, distal, autosomal recessive 10.7
172 spondyloepimetaphyseal dysplasia with joint laxity, type 2 10.7
173 langerhans cell histiocytosis 10.7
174 spondyloepimetaphyseal dysplasia, matrilin-3 related 10.7
175 multiple synostoses syndrome 2 10.7
176 spondyloepimetaphyseal dysplasia, aggrecan type 10.7
177 multiple synostoses syndrome 3 10.7
178 catel-manzke syndrome 10.7
179 multiple synostoses syndrome 4 10.7
180 spondyloepimetaphyseal dysplasia with joint laxity, type 3 10.7
181 cole-carpenter syndrome 10.7
182 bone development disease 10.7
183 bone structure disease 10.7
184 gastroparesis 10.7
185 melorheostosis 10.7
186 osteochondritis dissecans 10.7
187 crystal arthropathies 10.7
188 chiari malformation 10.7 FGFR3 DKK1
189 giant cell reparative granuloma 10.7 TNFRSF11A CALCA
190 uremic neuropathy 10.7 PTH B2M
191 urinary system disease 10.6 PTH FGF23 B2M
192 dysplasia epiphysealis hemimelica 10.6 EXT2 EXT1
193 secondary hyperparathyroidism of renal origin 10.6 VDR TNFRSF11B PTH FGF23 CALCA BGLAP
194 bone mineral density quantitative trait locus 8 10.6
195 bone mineral density quantitative trait locus 15 10.6
196 avascular necrosis 10.5
197 osteochondroma 10.5 FGFR3 EXT2 EXT1
198 tick infestation 10.5 ALPP ALPL
199 mammary paget's disease 10.5
200 secondary hyperparathyroidism 10.5
201 hereditary multiple osteochondromas 10.4 EXT2 EXT1
202 bone mineral density quantitative trait locus 3 10.2
203 liver cirrhosis 10.2
204 hypogonadism 10.1
205 hypogonadotropism 10.1
206 cystic fibrosis 10.1
207 primary biliary cholangitis 10.1
208 arterial calcification, generalized, of infancy, 1 10.1
209 primary biliary cirrhosis 10.1
210 liver disease 10.1
211 breast cancer 10.1
212 severe combined immunodeficiency 10.1
213 hyperthyroidism 10.1
214 osteogenic sarcoma 10.1
215 inflammatory bowel disease 10.1
216 thalassemia 10.1
217 prostate cancer 10.0
218 cholestasis 10.0
219 metabolic acidosis 10.0
220 renal tubular acidosis 10.0
221 overnutrition 10.0
222 fibrosis of extraocular muscles, congenital, 1 10.0
223 adenoma 10.0
224 multiple enchondromatosis, maffucci type 10.0 EXT2 EXT1
225 nephrolithiasis, calcium oxalate 10.0
226 hemosiderosis 10.0
227 rare hereditary hemochromatosis 10.0
228 deficiency anemia 10.0
229 short stature and advanced bone age, with or without early-onset osteoarthritis and/or osteochondritis dissecans 9.9
230 bone cancer 9.9
231 acromegaly 9.9
232 nephrocalcinosis 9.9
233 crohn's disease 9.9
234 neurofibromatosis, type ii 9.9
235 graves disease 1 9.9
236 hypophosphatemic rickets, x-linked recessive 9.9
237 autosomal recessive disease 9.9
238 myopathy 9.9
239 osteoarthritis 9.9
240 arthritis 9.9
241 amyloidosis 9.9
242 diabetes mellitus 9.9
243 47,xyy 9.9
244 renal cell carcinoma, nonpapillary 9.9
245 celiac disease 1 9.9
246 leukemia 9.9
247 hypothyroidism 9.9
248 triiodothyronine receptor auxiliary protein 9.8
249 leptin deficiency or dysfunction 9.8
250 complement factor b deficiency 9.8
251 scoliosis 9.8
252 lymphocytic leukemia 9.8
253 combined t cell and b cell immunodeficiency 9.8
254 cytokine deficiency 9.8
255 distal renal tubular acidosis 9.8
256 pseudoachondroplasia 9.8
257 achondroplasia 9.8
258 autoimmune disease 9.8
259 hypervitaminosis a 9.8
260 immune deficiency disease 9.8
261 osteoporosis-pseudoglioma syndrome 9.8
262 hypophosphatemic rickets, x-linked dominant 9.8
263 cystinosis 9.8
264 spondyloarthropathy 9.8
265 inflammatory spondylopathy 9.8
266 echinococcosis 9.8
267 kidney cancer 9.8
268 spondylitis 9.8
269 ulcerative colitis 9.8
270 cholangitis 9.8
271 sickle cell disease 9.8
272 carpal tunnel syndrome 9.7
273 insulin-like growth factor i 9.7
274 body mass index quantitative trait locus 11 9.7
275 body mass index quantitative trait locus 9 9.7
276 body mass index quantitative trait locus 8 9.7
277 body mass index quantitative trait locus 1 9.7
278 anorexia nervosa 9.7
279 body mass index quantitative trait locus 4 9.7
280 body mass index quantitative trait locus 10 9.7
281 body mass index quantitative trait locus 7 9.7
282 body mass index quantitative trait locus 12 9.7
283 body mass index quantitative trait locus 14 9.7
284 beta-thalassemia 9.7
285 body mass index quantitative trait locus 18 9.7
286 body mass index quantitative trait locus 19 9.7
287 body mass index quantitative trait locus 20 9.7
288 fanconi syndrome 9.7
289 chondrocalcinosis 9.7
290 nephrotic syndrome 9.7
291 neutropenia 9.7
292 alcohol use disorder 9.7
293 vascular disease 9.7
294 synovitis 9.7
295 primary hyperoxaluria 9.7
296 plasmacytoma 9.7
297 pseudohypoparathyroidism 9.7
298 lung disease 9.7
299 aminoaciduria 9.7
300 skeletal dysplasias 9.7
301 slipped capital femoral epiphysis 9.7
302 splenomegaly 9.7
303 juvenile primary osteoporosis 9.7
304 back pain 9.7
305 thyroid carcinoma 9.7
306 apert syndrome 9.7
307 klippel-feil syndrome 9.7
308 ehlers-danlos syndrome 9.7
309 acroosteolysis dominant type 9.7
310 alcohol dependence 9.7
311 spondyloarthropathy 1 9.7
312 fibrodysplasia ossificans progressiva 9.7
313 hypochondroplasia 9.7
314 legg-calve-perthes disease 9.7
315 leukemia, chronic lymphocytic 9.7
316 neurofibromatosis, type iv, of riccardi 9.7
317 chondrosarcoma 9.7
318 cystinosis, nephropathic 9.7
319 chronic recurrent multifocal osteomyelitis 9.7
320 pycnodysostosis 9.7
321 leukemia, acute lymphoblastic 9.7
322 cholangitis, primary sclerosing 9.7
323 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7
324 sensorineural hearing loss 9.7
325 osteopoikilosis 9.7
326 obstructive jaundice 9.7
327 biliary atresia 9.7
328 sapho syndrome 9.7
329 sclerosing cholangitis 9.7
330 rheumatic disease 9.7
331 thrombocytopenia 9.7
332 enthesopathy 9.7
333 acute kidney failure 9.7
334 mastocytosis 9.7
335 pancreatitis 9.7
336 paraplegia 9.7
337 homocystinuria 9.7
338 48,xyyy 9.7
339 bronchopulmonary dysplasia 9.7
340 growth hormone deficiency 9.7
341 leukemia, b-cell, chronic 9.7
342 hereditary hypophosphatemic rickets 9.7
343 angiomatosis 9.7
344 encephalopathy 9.7
345 myotonia 9.7
346 wilms tumor 5 9.7
347 pseudohypoparathyroidism, type ia 9.6
348 caffey disease 9.6
349 colorectal cancer 9.6
350 cherubism 9.6
351 multiple endocrine neoplasia, type i 9.6
352 fanconi renotubular syndrome 1 9.6
353 systemic lupus erythematosus 9.6
354 myositis 9.6
355 neurofibromatosis, type i 9.6
356 mccune-albright syndrome 9.6
357 dowling-degos disease 1 9.6
358 vitiligo-associated multiple autoimmune disease susceptibility 6 9.6
359 lung cancer 9.6
360 enterocolitis 9.6
361 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.6
362 van buchem disease 9.6
363 myelofibrosis 9.6
364 schwartz-jampel syndrome, type 1 9.6
365 myxedema 9.6
366 osteogenesis imperfecta, type iii 9.6
367 phenylketonuria 9.6
368 aging 9.6
369 prostatic hyperplasia, benign 9.6
370 suppression of tumorigenicity 12 9.6
371 yemenite deaf-blind hypopigmentation syndrome 9.6
372 branchiootic syndrome 1 9.6
373 homocysteinemia 9.6
374 sickle cell anemia 9.6
375 vitiligo-associated multiple autoimmune disease susceptibility 1 9.6
376 psoriatic arthritis 9.6
377 hepatitis c virus 9.6
378 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.6
379 gastric cancer 9.6
380 mucopolysaccharidosis-plus syndrome 9.6
381 fibroma 9.6
382 crohn's colitis 9.6
383 short bowel syndrome 9.6
384 prostatic hypertrophy 9.6
385 microcytic anemia 9.6
386 heart disease 9.6
387 otosclerosis 9.6
388 spinal muscular atrophy 9.6
389 acute leukemia 9.6
390 dementia 9.6
391 diarrhea 9.6
392 exocrine pancreatic insufficiency 9.6
393 algoneurodystrophy 9.6
394 frozen shoulder 9.6
395 impotence 9.6
396 viral hepatitis 9.6
397 dysostosis 9.6
398 cerebral palsy 9.6
399 constipation 9.6
400 spondylosis 9.6
401 hemangioma 9.6
402 chondroma 9.6
403 dermatitis 9.6
404 prostatic adenoma 9.6
405 bursitis 9.6
406 adenocarcinoma 9.6
407 lipid metabolism disorder 9.6
408 lysosomal storage disease 9.6
409 skin carcinoma 9.6
410 systemic mastocytosis 9.6
411 dentinogenesis imperfecta 9.6
412 hyperglycemia 9.6
413 middle ear disease 9.6
414 hemolytic anemia 9.6
415 cerebrovascular disease 9.6
416 juvenile rheumatoid arthritis 9.6
417 b-cell lymphoma 9.6
418 peptic ulcer disease 9.6
419 muscular atrophy 9.6
420 gastrointestinal system disease 9.6
421 measles 9.6
422 lupus erythematosus 9.6
423 macroglobulinemia 9.6
424 tenosynovitis 9.6
425 dwarfism 9.6
426 plasma cell leukemia 9.6
427 primary bone cancer 9.6
428 spondylarthropathy 9.6
429 bunion 9.6
430 multiple endocrine neoplasia 9.6
431 headache 9.6
432 hypoxia 9.6
433 mucopolysaccharidoses 9.6
434 pik3ca-related overgrowth syndrome 9.6
435 hematopoietic stem cell transplantation 9.6
436 rare disease in surgical orthopedic 9.6
437 overgrowth syndrome 9.6
438 eosinophilic granuloma 9.6
439 acanthosis nigricans 9.5
440 acroosteolysis 9.5
441 bladder cancer 9.5
442 boomerang dysplasia 9.5
443 alagille syndrome 1 9.5
444 cleft palate, isolated 9.5
445 crouzon syndrome 9.5
446 keratitis, hereditary 9.5
447 marfan syndrome 9.5
448 osteogenesis imperfecta, type ii 9.5
449 osteoglophonic dysplasia 9.5
450 papillomatosis, confluent and reticulated 9.5
451 sella turcica, bridged 9.5
452 sprengel deformity 9.5
453 chromosome 2q35 duplication syndrome 9.5
454 neuropathy, hereditary sensory and autonomic, type iii 9.5
455 ellis-van creveld syndrome 9.5
456 lichtenstein syndrome 9.5
457 multicentric osteolysis, nodulosis, and arthropathy 9.5
458 muenke syndrome 9.5
459 anxiety 9.5
460 spondylocostal dysostosis 3, autosomal recessive 9.5
461 crouzon syndrome with acanthosis nigricans 9.5
462 achondroplasia, severe, with developmental delay and acanthosis nigricans 9.5
463 brachydactyly 9.5
464 atelosteogenesis 9.5
465 colorectal adenoma 9.5
466 stickler syndrome 9.5
467 mood disorder 9.5
468 septic arthritis 9.5
469 degenerative disc disease 9.5
470 exophthalmos 9.5
471 fasciitis 9.5
472 plantar fasciitis 9.5
473 cold-induced sweating syndrome including crisponi syndrome 9.5
474 fgfr-related craniosynostosis syndromes 9.5
475 multiple epiphyseal dysplasia, recessive 9.5
476 type ii collagen disorders 9.5
477 fibromatosis multiple non ossifying 9.5
478 horseshoe kidney 9.5
479 simpson-golabi-behmel syndrome 9.5
480 hereditary neuropathies 9.5
481 paraneoplastic syndromes 9.5
482 syncope 9.5
483 campomelic dysplasia and related disorders 9.5
484 spondyloepiphyseal dysplasia with congenital joint dislocations 9.5
485 wilms tumor 1 9.5
486 arthropathy, progressive pseudorheumatoid, of childhood 9.5
487 osteopetrosis, autosomal recessive 1 9.5
488 spondyloocular syndrome 9.5
489 epiphyseal dysplasia, multiple, 5 9.5
490 aortic aneurysm, familial thoracic 1 9.5
491 complement component 3 deficiency, autosomal recessive 9.5
492 tendinopathy 9.5
493 tendinitis 9.5
494 autonomic neuropathy 9.5
495 epicondylitis 9.5
496 hyperinsulinism 9.5
497 pulmonary tuberculosis 9.5
498 periarthritis 9.5
499 rhabdomyosarcoma 9.5
500 teratocarcinoma 9.5
501 teratoma 9.5
502 aortic aneurysm 9.5
503 blood protein disease 9.5
504 complement component 3 deficiency 9.5
505 vasculitis 9.5
506 myeloid sarcoma 9.5
507 diabetic neuropathy 9.5
508 familial osteochondritis dissecans 9.5
509 rosai-dorfman disease 9.5
510 paresthesia 9.5
511 autosomal recessive malignant osteopetrosis 9.5
512 idiopathic avascular necrosis 9.5
513 lumbar syndrome 9.5
514 arteries, anomalies of 9.4
515 atherosclerosis susceptibility 9.4
516 gastroesophageal reflux 9.4
517 craniometaphyseal dysplasia, autosomal dominant 9.4
518 camurati-engelmann disease 9.4
519 esophageal cancer 9.4
520 factor viii deficiency 9.4
521 hypercholesterolemia, familial, 1 9.4
522 mastocytosis, cutaneous 9.4
523 thyroid carcinoma, familial medullary 9.4
524 metaphyseal chondrodysplasia, schmid type 9.4
525 nevus, epidermal 9.4
526 schimmelpenning-feuerstein-mims syndrome 9.4
527 osteogenesis imperfecta, type iv 9.4
528 gnathodiaphyseal dysplasia 9.4
529 osteomesopyknosis 9.4
530 prolidase deficiency 9.4
531 pheochromocytoma 9.4
532 polyposis, gastric 9.4
533 hutchinson-gilford progeria syndrome 9.4
534 retinal detachment 9.4
535 sarcoidosis 1 9.4
536 scheuermann disease 9.4
537 scleroderma, familial progressive 9.4
538 scoliosis, isolated 1 9.4
539 slipped femoral capital epiphyses 9.4
540 small cell cancer of the lung 9.4
541 neural tube defects 9.4
542 temporal arteritis 9.4
543 down syndrome 9.4
544 alkaptonuria 9.4
545 biliary atresia, extrahepatic 9.4
546 tumoral calcinosis, hyperphosphatemic, familial, 1 9.4
547 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 9.4
548 persistent hyperplastic primary vitreous, autosomal recessive 9.4
549 lysinuric protein intolerance 9.4
550 hemochromatosis, type 1 9.4
551 hypoascorbemia 9.4
552 hypogonadism, male 9.4
553 chylomicron retention disease 9.4
554 marden-walker syndrome 9.4
555 proteasome-associated autoinflammatory syndrome 1 9.4
556 neuroblastoma 1 9.4
557 panencephalitis, subacute sclerosing 9.4
558 vitamin d hydroxylation-deficient rickets, type 1a 9.4
559 pseudoxanthoma elasticum 9.4
560 pyle disease 9.4
561 rothmund-thomson syndrome 9.4
562 thrombocytopenia-absent radius syndrome 9.4
563 vitamin d-dependent rickets, type 2a 9.4
564 dent disease 1 9.4
565 focal dermal hypoplasia 9.4
566 hemophilia a 9.4
567 menkes disease 9.4
568 muscular dystrophy, duchenne type 9.4
569 norrie disease 9.4
570 diabetes and deafness, maternally inherited 9.4
571 gallbladder disease 1 9.4
572 asthma 9.4
573 dermatitis herpetiformis, familial 9.4
574 stroke, ischemic 9.4
575 stuve-wiedemann syndrome 9.4
576 ossification of the posterior longitudinal ligament of spine 9.4
577 reflex sympathetic dystrophy 9.4
578 scheie syndrome 9.4
579 nasopharyngeal carcinoma 9.4
580 creatinine clearance quantitative trait locus 9.4
581 coronary heart disease 1 9.4
582 patent ductus arteriosus 1 9.4
583 aural atresia, congenital 9.4
584 parathyroid carcinoma 9.4
585 choanal atresia, posterior 9.4
586 majeed syndrome 9.4
587 hyperparathyroidism 3 9.4
588 osteogenesis imperfecta, type vii 9.4
589 osteogenesis imperfecta, type v 9.4
590 ewing sarcoma 9.4
591 inflammatory bowel disease 19 9.4
592 lung cancer susceptibility 3 9.4
593 microvascular complications of diabetes 3 9.4
594 microvascular complications of diabetes 4 9.4
595 microvascular complications of diabetes 6 9.4
596 microvascular complications of diabetes 7 9.4
597 odontoid hypoplasia 9.4
598 osteogenesis imperfecta, type vi 9.4
599 myelodysplastic syndrome 9.4
600 graft-versus-host disease 9.4
601 retinal dystrophy, iris coloboma, and comedogenic acne syndrome 9.4
602 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 9.4
603 leukemia, acute lymphoblastic 3 9.4
604 hydrops, lactic acidosis, and sideroblastic anemia 9.4
605 nevus comedonicus 9.4
606 helix syndrome 9.4
607 angina pectoris 9.4
608 pulmonary hypertension 9.4
609 congenital hypothyroidism 9.4
610 adult t-cell leukemia 9.4
611 exudative vitreoretinopathy 9.4
612 female breast cancer 9.4
613 paraganglioma 9.4
614 peripheral artery disease 9.4
615 sleep apnea 9.4
616 oral squamous cell carcinoma 9.4
617 adrenal gland pheochromocytoma 9.4
618 lymphoma 9.4
619 pain agnosia 9.4
620 colitis 9.4
621 basal ganglia calcification 9.4
622 idiopathic scoliosis 9.4
623 persistent hyperplastic primary vitreous 9.4
624 inguinal hernia 9.4
625 progressive familial intrahepatic cholestasis 9.4
626 childhood acute lymphocytic leukemia 9.4
627 non-alcoholic fatty liver disease 9.4
628 polycystic kidney disease 9.4
629 non-alcoholic steatohepatitis 9.4
630 dermatomyositis 9.4
631 chronic meningitis 9.4
632 pre-eclampsia 9.4
633 microphthalmia 9.4
634 cholesteatoma of middle ear 9.4
635 lipoid nephrosis 9.4
636 sarcoma 9.4
637 vitamin k deficiency bleeding 9.4
638 gestational diabetes 9.4
639 iron deficiency anemia 9.4
640 leukocoria 9.4
641 visual epilepsy 9.4
642 cryptococcosis 9.4
643 cartilage disease 9.4
644 male infertility 9.4
645 pancytopenia 9.4
646 hepatitis a 9.4
647 hepatic coma 9.4
648 multiple epiphyseal dysplasia 9.4
649 quadriplegia 9.4
650 focal segmental glomerulosclerosis 9.4
651 uveitis 9.4
652 acute cystitis 9.4
653 gout 9.4
654 hepatic encephalopathy 9.4
655 tuberous sclerosis 9.4
656 eclampsia 9.4
657 hypermobility syndrome 9.4
658 facial paralysis 9.4
659 childhood type dermatomyositis 9.4
660 ochronosis 9.4
661 gonadal dysgenesis 9.4
662 blount's disease 9.4
663 cystic echinococcosis 9.4
664 urticaria 9.4
665 neuroendocrine tumor 9.4
666 richter's syndrome 9.4
667 ossifying fibroma 9.4
668 calcinosis 9.4
669 epilepsy 9.4
670 hepatitis c 9.4
671 dental caries 9.4
672 craniosynostosis 9.4
673 arteriosclerosis 9.4
674 iron metabolism disease 9.4
675 sensory peripheral neuropathy 9.4
676 hairy cell leukemia 9.4
677 hemoglobinopathy 9.4
678 glomerulonephritis 9.4
679 lipomatosis 9.4
680 ischemia 9.4
681 fibrosarcoma 9.4
682 bone osteosarcoma 9.4
683 histiocytosis 9.4
684 breast disease 9.4
685 cellulitis 9.4
686 turner syndrome 9.4
687 skin disease 9.4
688 extramedullary plasmacytoma 9.4
689 solitary osseous plasmacytoma 9.4
690 lung squamous cell carcinoma 9.4
691 thyroid gland medullary carcinoma 9.4
692 nail disease 9.4
693 secondary syphilis 9.4
694 syphilis 9.4
695 spindle cell sarcoma 9.4
696 radiculopathy 9.4
697 erdheim-chester disease 9.4
698 pustulosis of palm and sole 9.4
699 seminoma 9.4
700 nutritional deficiency disease 9.4
701 infertility 9.4
702 intestinal disease 9.4
703 peripheral nervous system disease 9.4
704 fibromyalgia 9.4
705 acquired immunodeficiency syndrome 9.4
706 connective tissue disease 9.4
707 diffuse idiopathic skeletal hyperostosis 9.4
708 myositis ossificans 9.4
709 compartment syndrome 9.4
710 t-cell leukemia 9.4
711 osgood-schlatter's disease 9.4
712 tertiary syphilis 9.4
713 cataract 9.4
714 ileus 9.4
715 retinal degeneration 9.4
716 dermatitis herpetiformis 9.4
717 eating disorder 9.4
718 perinatal necrotizing enterocolitis 9.4
719 neuropathy 9.4
720 rosacea 9.4
721 psoriasis 9.4
722 parapsoriasis 9.4
723 diabetes insipidus 9.4
724 fatty liver disease 9.4
725 smoldering myeloma 9.4
726 neurofibroma 9.4
727 irritable bowel syndrome 9.4
728 muscular dystrophy 9.4
729 multiple epiphyseal dysplasia, autosomal dominant 9.4
730 plod1-related kyphoscoliotic ehlers-danlos syndrome 9.4
731 trichorhinophalangeal syndrome 9.4
732 al amyloidosis 9.4
733 arachnoid cysts 9.4
734 bone marrow necrosis 9.4
735 bowing of long bones congenital 9.4
736 chromosomal triplication 9.4
737 chronic graft versus host disease 9.4
738 familial tumoral calcinosis 9.4
739 germ cells tumors 9.4
740 lathyrism 9.4
741 leukemia, t-cell, chronic 9.4
742 lymphangiomatosis 9.4
743 medullary sponge kidney 9.4
744 oncogenic osteomalacia 9.4
745 precocious puberty 9.4
746 pseudohypoparathyroidism with albright hereditary osteodystrophy 9.4
747 single ventricular heart 9.4
748 urachal cancer 9.4
749 brain injury 9.4
750 chronic pain 9.4
751 cytomegalovirus infection 9.4
752 dysautonomia 9.4
753 hypotonia 9.4
754 overuse syndrome 9.4
755 seizure disorder 9.4
756 systemic autoimmune disease 9.4
757 rapidly involuting congenital hemangioma 9.4
758 idiopathic nephrotic syndrome 9.4
759 phalangeal microgeodic syndrome 9.4
760 disorders of vitamin d metabolism 9.4
761 familial intrahepatic cholestasis 9.4
762 chondromyxoid fibroma 9.4
763 monostotic fibrous dysplasia 9.4
764 primary bone dysplasia with increased bone density 9.4
765 lethal chondrodysplasia 9.4
766 fgfr3-related chondrodysplasia 9.4
767 refractory anemia 9.4
768 vitreoretinopathy 9.4
769 precursor t-cell acute lymphoblastic leukemia 9.4

Graphical network of the top 20 diseases related to Bone Disease:



Diseases related to Bone Disease
Sources

Symptoms & Phenotypes for Bone Disease

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UMLS symptoms related to Bone Disease:


back pain, bone pain, sciatica, muscle cramp

MGI Mouse Phenotypes related to Bone Disease:

46 (showing 13, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.3 ALPL B2M CTSK DKK1 EXT1 FGFR3
2 growth/size/body region MP:0005378 10.3 ALPL B2M CTSK DKK1 EXT1 FGF23
3 craniofacial MP:0005382 10.25 ALPL CTSK DKK1 EXT1 FGFR3 PTH
4 homeostasis/metabolism MP:0005376 10.18 ALPL B2M CTSK DKK1 FGF23 FGFR3
5 hematopoietic system MP:0005397 10.17 ALPL B2M CTSK FGF23 FGFR3 PTH
6 digestive/alimentary MP:0005381 10.15 ALPL B2M CTSK EXT1 FGF23 FGFR3
7 endocrine/exocrine gland MP:0005379 10.13 ALPL B2M CTSK FGF23 PTH RUNX2
8 immune system MP:0005387 10.11 ALPL B2M CTSK FGF23 FGFR3 PTH
9 limbs/digits/tail MP:0005371 10.07 ALPL CTSK DKK1 EXT1 FGF23 FGFR3
10 mortality/aging MP:0010768 9.97 ALPL B2M DKK1 EXT1 EXT2 FGF23
11 integument MP:0010771 9.92 B2M EXT1 FGF23 FGFR3 RUNX2 TNFRSF11A
12 respiratory system MP:0005388 9.56 ALPL CTSK DKK1 FGF23 FGFR3 RUNX2
13 skeleton MP:0005390 9.47 ALPL CTSK DKK1 EXT1 EXT2 FGF23
Sources

Drugs & Therapeutics for Bone Disease

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Drugs for Bone Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 410, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
2
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
3
Tocopherol Approved, Investigational Phase 4 1406-66-2, 54-28-4 14986
4
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
5
Lactulose Approved Phase 4 4618-18-2 11333
6
Tibolone Approved, Investigational Phase 4 5630-53-5
7
Mecasermin Approved, Investigational Phase 4 68562-41-4
8
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
9
Gliclazide Approved Phase 4 21187-98-4 3475
10
Vildagliptin Approved, Investigational Phase 4 274901-16-5 6918537
11
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
12
Methamphetamine Approved, Illicit Phase 4 537-46-2 10836
13
Norelgestromin Approved, Investigational Phase 4 53016-31-2 13752005
14
Cobicistat Approved Phase 4 1004316-88-4
15
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
16
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
17
Methadone Approved, Illicit Phase 4 76-99-3 4095
18
Velpatasvir Approved, Investigational Phase 4 1377049-84-7 67683363
19
Doxorubicin Approved, Investigational Phase 4 23214-92-8 31703
20
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
21
Acetaminophen Approved Phase 4 103-90-2 1983
22
Desogestrel Approved Phase 4 54024-22-5 40973
23
Etonogestrel Approved, Investigational Phase 4 54048-10-1 6917715 40976
24
Abatacept Approved Phase 4 332348-12-6 10237
25
Promethazine Approved, Investigational Phase 4 60-87-7 4927
26
alemtuzumab Approved, Investigational Phase 4 216503-57-0
27
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
28
Methyltestosterone Approved Phase 4 58-18-4 6010
29
Testosterone enanthate Approved Phase 4 315-37-7 9416
30
Testosterone Approved, Experimental, Investigational Phase 4 481-30-1, 58-22-0 6013 10204
31
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
32
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
33
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
34
Mycophenolic acid Approved Phase 4 24280-93-1 446541
35
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
36
Emtricitabine Approved, Investigational Phase 4 143491-57-0 60877
37
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
38
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
39
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
40
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
41
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
42
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 11103-57-4, 68-26-8 9904001 445354
43
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
44
Alfacalcidol Approved, Nutraceutical Phase 4 41294-56-8 5282181
45
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
46
Calcitriol Approved, Nutraceutical Phase 4 32222-06-3 5280453 134070
47 Tocotrienol Investigational Phase 4 6829-55-6
48
Tenofovir Experimental, Investigational Phase 4 147127-20-6 464205
49
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
50 retinol Phase 4
51 Retinol palmitate Phase 4
52 Nitric Oxide Donors Phase 4
53 isosorbide-5-mononitrate Phase 4
54 Omega 3 Fatty Acid Phase 4
55 Tocotrienols Phase 4
56 Tocopherols Phase 4
57 Liver Extracts Phase 4
58 Mitogens Phase 4
59 triamcinolone acetonide Phase 4
60 Triamcinolone hexacetonide Phase 4
61 Triamcinolone diacetate Phase 4
62 Neurotransmitter Agents Phase 4
63 Central Nervous System Stimulants Phase 4
64 Hepcidins Phase 4
65 Selective Estrogen Receptor Modulators Phase 4
66 Estrogen Receptor Modulators Phase 4
67 Raloxifene Hydrochloride Phase 4
68 Androgen Antagonists Phase 4
69 Dialysis Solutions Phase 4