MCID: BNW001
MIFTS: 48

Bone Ewing's Sarcoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Bone Ewing's Sarcoma

MalaCards integrated aliases for Bone Ewing's Sarcoma:

Name: Bone Ewing's Sarcoma 12 15
Ewing's Sarcoma of Bone 12 74
Ewing's Sarcoma/bone Peripheral Primitive Neuroectodermal Tumor 12
Localized Skeletal Ewing's Sarcoma 12
Bone Localized Ewing's Sarcoma 12
Bone Localized Ewing Sarcoma 12
Localized Bone Ewing Sarcoma 74
Skeletal Ewing's Tumor 12
Bone Ewing Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3368

Summaries for Bone Ewing's Sarcoma

Disease Ontology : 12 A peripheral primitive neuroectodermal tumor that is located in bone.

MalaCards based summary : Bone Ewing's Sarcoma, also known as ewing's sarcoma of bone, is related to rhabdomyosarcoma and ewing sarcoma, and has symptoms including fever and pain. An important gene associated with Bone Ewing's Sarcoma is MDN1 (Midasin AAA ATPase 1), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Human T-cell leukemia virus 1 infection. The drugs Bevacizumab and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and eye, and related phenotypes are growth/size/body region and mortality/aging

Related Diseases for Bone Ewing's Sarcoma

Diseases related to Bone Ewing's Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 rhabdomyosarcoma 30.1 ENO2 EWSR1 MYCN PTPRC
2 ewing sarcoma 28.3 CD99 ENO2 ETS1 EWSR1 MYC MYCN
3 sarcoma 10.5
4 rhabdoid cancer 10.4 ENO2 EWSR1
5 small cell osteogenic sarcoma 10.4 ENO2 EWSR1
6 cauda equina neoplasm 10.4 ENO2 EWSR1
7 plexiform schwannoma 10.4 B3GAT1 ENO2
8 adrenal neuroblastoma 10.4 ENO2 MYCN
9 extraosseous chondrosarcoma 10.3 ENO2 EWSR1
10 bednar tumor 10.3 ENO2 PDGFB
11 desmoplastic small round cell tumor 10.3 ENO2 EWSR1
12 autonomic nervous system benign neoplasm 10.3 ENO2 MYCN
13 nodular ganglioneuroblastoma 10.3 ENO2 MYCN
14 head injury 10.2 CHAT ENO2
15 primitive neuroectodermal tumor of the cervix uteri 10.2 ENO2 PTPRC
16 rhabdomyosarcoma 2 10.2 ENO2 EWSR1 MYCN
17 dermis tumor 10.2 B3GAT1 PDGFB
18 vulvar sarcoma 10.2 EWSR1 PTPRC
19 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 B3GAT1 PTPRC
20 conventional fibrosarcoma 10.2 ENO2 PTPRC
21 hodgkin's lymphoma, mixed cellularity 10.2 B3GAT1 PTPRC
22 bladder sarcoma 10.2 CD99 EWSR1
23 endometrial small cell carcinoma 10.2 ENO2 PTPRC
24 marcus gunn phenomenon 10.1 CHAT MYC
25 spindle cell sarcoma 10.1
26 cerebral primitive neuroectodermal tumor 10.1 ENO2 MYC MYCN
27 olfactory neuroblastoma 10.1 ENO2 EWSR1 PTPRC
28 tendinitis 10.1 PDGFB PHB2
29 medullomyoblastoma 10.1 ENO2 MYC MYCN
30 autonomic nervous system neoplasm 10.1 ENO2 MYC MYCN
31 peripheral nervous system neoplasm 10.1 ENO2 MYC MYCN
32 gastric small cell carcinoma 10.1 B3GAT1 ENO2 PTPRC
33 central nervous system cancer 10.1 ENO2 MYC MYCN
34 nervous system disease 10.1 CHAT ENO2 MYCN
35 small cell cancer of the lung 10.1 ENO2 MYC MYCN
36 ovarian lymphoma 10.0 MYC PTPRC
37 malignant histiocytosis 10.0 MYB MYC PDGFB
38 hypertrichosis universalis congenita, ambras type 10.0 MYC PHB2
39 pericardium cancer 10.0 CD99 ENO2 MYCN
40 askin's tumor 10.0 ENO2 EWSR1 MYC MYCN
41 nervous system cancer 10.0 ENO2 EWSR1 MYC MYCN
42 breast adenomyoepithelioma 9.9 CD99 ENO2
43 intracranial primitive neuroectodermal tumor 9.9 CD99 CENPV ENO2
44 breast myoepithelial neoplasm 9.9 CD99 ENO2
45 epidural neoplasm 9.9 CD99 PTPRC
46 brain cancer 9.9 ENO2 MYC MYCN PDGFB
47 connective tissue cancer 9.8 CD99 ENO2 EWSR1 PDGFB
48 wilms tumor 1 9.8 ENO2 EWSR1 MYB MYC MYCN
49 extraskeletal ewing sarcoma 9.8 CD99 ENO2 EWSR1 PTPRC
50 medulloblastoma 9.7 ENO2 MYC MYCN PDGFB

Graphical network of the top 20 diseases related to Bone Ewing's Sarcoma:



Diseases related to Bone Ewing's Sarcoma

Symptoms & Phenotypes for Bone Ewing's Sarcoma

UMLS symptoms related to Bone Ewing's Sarcoma:


fever, pain

MGI Mouse Phenotypes related to Bone Ewing's Sarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10 CHAT ENO2 ETS1 FES LONP1 MYB
2 mortality/aging MP:0010768 9.7 B3GAT1 CHAT ETS1 FES LONP1 MYB
3 liver/biliary system MP:0005370 9.63 FES MYB MYC MYCN PDGFB PTPRC
4 nervous system MP:0003631 9.28 B3GAT1 CHAT ENO2 FES LONP1 MYC

Drugs & Therapeutics for Bone Ewing's Sarcoma

Drugs for Bone Ewing's Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 48)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2
Vincristine Approved, Investigational Phase 2,Not Applicable 2068-78-2, 57-22-7 5978
3
Cyclophosphamide Approved, Investigational Phase 2,Not Applicable 6055-19-2, 50-18-0 2907
4
Topotecan Approved, Investigational Phase 2,Not Applicable 123948-87-8, 119413-54-6 60700
5
Doxorubicin Approved, Investigational Phase 2,Not Applicable 23214-92-8 31703
6
Etoposide Approved Phase 2,Not Applicable 33419-42-0 36462
7
Ifosfamide Approved Phase 2,Not Applicable 3778-73-2 3690
8
Lenograstim Approved, Investigational Phase 2,Not Applicable 135968-09-1
9
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
10
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
11
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
12
Mechlorethamine Approved, Investigational Phase 2,Not Applicable 51-75-2 4033
13
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
14
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
15
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
16
Doxil Approved June 1999 Phase 2,Not Applicable 31703
17 Angiogenesis Inhibitors Phase 2
18 Immunoglobulins Phase 2
19 Angiogenesis Modulating Agents Phase 2
20 Antineoplastic Agents, Alkylating Phase 2,Not Applicable
21 Antibodies, Monoclonal Phase 2
22 Antineoplastic Agents, Immunological Phase 2
23 Immunosuppressive Agents Phase 2,Not Applicable
24 Antibodies Phase 2
25 Immunologic Factors Phase 2,Not Applicable
26 Topoisomerase Inhibitors Phase 2,Not Applicable
27 Alkylating Agents Phase 2,Not Applicable
28 Antimitotic Agents Phase 2,Not Applicable
29 topoisomerase I inhibitors Phase 2,Not Applicable
30 Antineoplastic Agents, Phytogenic Phase 2,Not Applicable
31 Antirheumatic Agents Phase 2,Not Applicable
32 Antibiotics, Antitubercular Phase 2,Not Applicable
33 Etoposide phosphate Phase 2,Not Applicable
34 Anti-Infective Agents Phase 2,Early Phase 1
35 Anti-Bacterial Agents Phase 2,Not Applicable
36
Isophosphamide mustard Phase 2,Not Applicable 0
37 Antifungal Agents Phase 2
38 Protein Kinase Inhibitors Phase 2
39 Cardiotonic Agents Phase 2
40 razoxane Phase 2
41 Protective Agents Phase 2
42
Dactinomycin Approved, Investigational 50-76-0 457193 2019
43
Alovudine Investigational Early Phase 1 25526-93-6
44 Fluorodeoxyglucose F18 Early Phase 1
45 Antiviral Agents Early Phase 1
46 Fluorides Early Phase 1
47 Radiopharmaceuticals Early Phase 1
48 Nucleic Acid Synthesis Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vincristine Sulfate, Topotecan Hydrochloride, and Cyclophosphamide With or Without Bevacizumab in Treating Young Patients With Refractory or First Recurrent Extracranial Ewing Sarcoma Completed NCT00516295 Phase 2 topotecan hydrochloride;vincristine sulfate;cyclophosphamide
2 A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
3 Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors Active, not recruiting NCT01946529 Phase 2 vincristine;doxorubicin;cyclophosphamide;ifosfamide;etoposide;temozolomide;temsirolimus;bevacizumab;sorafenib
4 Combination Chemotherapy and Dexrazoxane Followed by Surgery and Radiation Therapy in Treating Patients With Advanced Soft Tissue Sarcoma or Recurrent Bone Sarcoma Terminated NCT00544778 Phase 2 dexrazoxane hydrochloride;doxorubicin hydrochloride;ifosfamide;irinotecan hydrochloride
5 Two Regimens of Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed Localized Ewing Sarcoma Family of Tumors Completed NCT00618813 Not Applicable etoposide;ifosfamide;doxorubicin hydrochloride;cyclophosphamide;vincristine sulfate;topotecan hydrochloride
6 18F-FLT Positron Emission Tomography and Diffusion-Weighted Magnetic Resonance Imaging in Planning Surgery and Radiation Therapy and Measuring Response in Patients With Newly Diagnosed Ewing Sarcoma Completed NCT01825902 Early Phase 1 fluorine F 18 fluorothymidine
7 Evaluating Dactinomycin and Vincristine in Young Patients With Cancer Completed NCT00674193
8 Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed By Stem Cell Rescue in Treating Patients With Poor-Risk Ewing Sarcoma Withdrawn NCT01795430 Not Applicable etoposide;ifosfamide;topotecan hydrochloride;busulfan;melphalan

Search NIH Clinical Center for Bone Ewing's Sarcoma

Genetic Tests for Bone Ewing's Sarcoma

Anatomical Context for Bone Ewing's Sarcoma

MalaCards organs/tissues related to Bone Ewing's Sarcoma:

42
Bone, Lung, Eye, Endothelial, Skeletal Muscle, Monocytes

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Ewing's Sarcoma:

20
Bone

Publications for Bone Ewing's Sarcoma

Articles related to Bone Ewing's Sarcoma:

(show top 50) (show all 80)
# Title Authors Year
1
Surgical Resection of Primary Ewing's Sarcoma of Bone Improves Overall Survival in Patients Presenting with Metastasis. ( 30770526 )
2019
2
A systematic review of optimal treatment strategies for localized Ewing's sarcoma of bone after neo-adjuvant chemotherapy. ( 26979636 )
2016
3
Evidence-based guideline recommendations on treatment strategies for localized Ewing's sarcoma of bone following neo-adjuvant chemotherapy. ( 27312034 )
2016
4
Ewing's sarcoma of bone tumor cells produces MCSF that stimulates monocyte proliferation in a novel mouse model of Ewing's sarcoma of bone. ( 26051470 )
2015
5
Ewing's sarcoma of bone. ( 25070232 )
2014
6
Bee-sting, a non-resolving wound and a progressive mass over the right eye preceding the ultimate diagnosis of frontal bone Ewing's sarcoma. ( 22761215 )
2012
7
Risk adapted chemotherapy for localised Ewing's sarcoma of bone: the French EW93 study. ( 22516209 )
2012
8
Health related quality of life and late side effects of long-term survivors of Ewing's sarcoma of bone. ( 22006761 )
2011
9
Role of radiation therapy in the multidisciplinary management of Ewing's Sarcoma of bone in pediatric patients: An effective treatment for local control. ( 24376965 )
2011
10
Long-lasting multiagent chemotherapy in adult high-risk Ewing's sarcoma of bone. ( 18989798 )
2009
11
The differential effects of the radioprotectant drugs amifostine and sodium selenite treatment in combination with radiation therapy on constituent bone cells, Ewing's sarcoma of bone tumor cells, and rhabdomyosarcoma tumor cells in vitro. ( 18473385 )
2008
12
Ewing's sarcoma of bone: ESMO clinical recommendations for diagnosis, treatment and follow-up. ( 17491059 )
2007
13
Ewing's sarcoma of bone: the detection of specific transcripts in a large, consecutive series of formalin-fixed, decalcified, paraffin-embedded tissue samples using the reverse transcriptase-polymerase chain reaction. ( 16487358 )
2006
14
ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of Ewing's sarcoma of bone. ( 15888765 )
2005
15
Surgery for lung metastases in Ewing's sarcoma of bone. ( 14736525 )
2004
16
Incidental detection of microfilariae in aspirates from Ewing's sarcoma of bone. ( 12827713 )
2003
17
ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of Ewing's sarcoma of bone. ( 12881370 )
2003
18
The treatment of Ewing's sarcoma of bone at the University of Florida: 1969 to 1998. ( 11953620 )
2002
19
Ewing's sarcoma of bone: relation between clinical characteristics and staging. ( 11295079 )
2001
20
Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli. ( 10623687 )
2000
21
Primary petrous bone Ewing's sarcoma. ( 10889890 )
2000
22
Neoadjuvant chemotherapy for Ewing's sarcoma of bone in patients older than thirty-nine years. ( 10752664 )
2000
23
Expression of neural cell adhesion molecules and neurofilament protein isoforms in Ewing's sarcoma of bone and soft tissue sarcomas other than rhabdomyosarcoma. ( 10534169 )
1999
24
Overexpression of p53 protein in primary Ewing's sarcoma of bone: relationship to tumour stage, response and prognosis. ( 10098757 )
1999
25
Prognostic significance of serum LDH in Ewing's sarcoma of bone. ( 10373661 )
1999
26
Neoadjuvant chemotherapy for Ewing's sarcoma of bone: no benefit observed after adding ifosfamide and etoposide to vincristine, actinomycin, cyclophosphamide, and doxorubicin in the maintenance phase--results of two sequential studies. ( 9506366 )
1998
27
Quantitative analysis of the plain radiographic appearance of Ewing's sarcoma of bone. ( 9007649 )
1997
28
The Impact of Radiotherapy Dose on Local Control of Ewing's Sarcoma of Bone. ( 18521198 )
1997
29
Long-term follow-up for patients with Ewing's sarcoma of bone treated with adjuvant and neoadjuvant chemotherapy. ( 21590179 )
1997
30
Ewing's sarcoma of bone--a study of 71 cases by fine needle aspiration cytology. ( 8854626 )
1996
31
Comparison of Ewing's sarcoma of bone and peripheral neuroepithelioma. ( 7487413 )
1995
32
Is neuro-ectodermal differentiation of Ewing's sarcoma of bone associated with an unfavourable prognosis? ( 7786593 )
1995
33
A comparative study of nuclear morphometry and proliferating activity in neuroectodermal tumors of bone and Ewing's sarcoma of bone. ( 8548592 )
1995
34
Ewing's sarcoma of bone: oncologic and functional results. ( 8551735 )
1995
35
Comparison of Ewing's sarcoma of bone and peripheral neuroepithelioma. An immunocytochemical and ultrastructural analysis of two primitive neuroectodermal neoplasms. ( 8204006 )
1994
36
Monitoring the effect of chemotherapy in Ewing's sarcoma of bone with MR imaging. ( 7824974 )
1994
37
Classification of histopathologic changes following chemotherapy in Ewing's sarcoma of bone. ( 7824975 )
1994
38
Negative 123-meta-iodobenzyl-guanidine imaging in Ewing's sarcoma of bone. ( 8202035 )
1994
39
No advantages in the addition of ifosfamide and VP-16 to the standard four-drug regimen in the maintenance phase of neoadjuvant chemotherapy of Ewing's sarcoma of bone: results of two sequential studies. ( 8229153 )
1993
40
Comparison of cell surface antigen HBA71 (p30/32MIC2), neuron-specific enolase, and vimentin in the immunohistochemical analysis of Ewing's sarcoma of bone. ( 1497115 )
1992
41
Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone. ( 1403056 )
1992
42
(Sub)periosteal Ewing's sarcoma of bone. ( 1729262 )
1992
43
Local control and function after twice-a-day radiotherapy for Ewing's sarcoma of bone. ( 1938560 )
1991
44
Long-term follow-up of Ewing's sarcoma of bone treated with combined modality therapy. ( 1995522 )
1991
45
Long-term follow-up of Ewing's sarcoma of bone. ( 1995554 )
1991
46
Combined therapy of localized Ewing's sarcoma of bone: analysis of results in 100 patients. ( 2254107 )
1990
47
Multimodal therapy for the management of nonpelvic, localized Ewing's sarcoma of bone: intergroup study IESS-II. ( 2099751 )
1990
48
Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study. ( 2213103 )
1990
49
Ewing's sarcoma of bone. ( 2092766 )
1990
50
Therapy for localized Ewing's sarcoma of bone. ( 2915236 )
1989

Variations for Bone Ewing's Sarcoma

Expression for Bone Ewing's Sarcoma

Search GEO for disease gene expression data for Bone Ewing's Sarcoma.

Pathways for Bone Ewing's Sarcoma

GO Terms for Bone Ewing's Sarcoma

Biological processes related to Bone Ewing's Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.73 ETS1 MYC MYCN PDGFB
2 positive regulation of transcription, DNA-templated GO:0045893 9.55 ETS1 MYB MYC MYCN PDGFB
3 positive regulation of DNA biosynthetic process GO:2000573 9.32 MYC PDGFB
4 positive regulation of smooth muscle cell migration GO:0014911 9.1 PDGFB
5 positive regulation of glial cell proliferation GO:0060252 9.07 MYB
6 hypothalamus development GO:0021854 8.96 ETS1
7 response to wounding GO:0009611 8.96 ETS1 PDGFB
8 positive regulation of smooth muscle cell proliferation GO:0048661 8.62 MYB PDGFB

Sources for Bone Ewing's Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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