MCID: BNW001
MIFTS: 50

Bone Ewing's Sarcoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Bone Ewing's Sarcoma

MalaCards integrated aliases for Bone Ewing's Sarcoma:

Name: Bone Ewing's Sarcoma 12 15
Ewing's Sarcoma of Bone 12 73
Ewing's Sarcoma/bone Peripheral Primitive Neuroectodermal Tumor 12
Localized Skeletal Ewing's Sarcoma 12
Bone Localized Ewing's Sarcoma 12
Bone Localized Ewing Sarcoma 12
Localized Bone Ewing Sarcoma 73
Skeletal Ewing's Tumor 12
Bone Ewing Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3368

Summaries for Bone Ewing's Sarcoma

Disease Ontology : 12 A peripheral primitive neuroectodermal tumor that is located in bone.

MalaCards based summary : Bone Ewing's Sarcoma, also known as ewing's sarcoma of bone, is related to ewing sarcoma and small cell osteogenic sarcoma, and has symptoms including fever and pain. An important gene associated with Bone Ewing's Sarcoma is MDN1 (Midasin AAA ATPase 1), and among its related pathways/superpathways are Immune response IL-23 signaling pathway and Human T-cell leukemia virus 1 infection. The drugs Vincristine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and kidney, and related phenotypes are growth/size/body region and cardiovascular system

Related Diseases for Bone Ewing's Sarcoma

Diseases related to Bone Ewing's Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 67)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 31.2 CD99 ENO2 ETS1 EWSR1 MYC MYCN
2 small cell osteogenic sarcoma 10.3 ENO2 EWSR1
3 adrenal neuroblastoma 10.2 ENO2 MYCN
4 plexiform schwannoma 10.2 B3GAT1 ENO2
5 extraosseous chondrosarcoma 10.2 ENO2 EWSR1
6 bednar tumor 10.2 ENO2 PDGFB
7 autonomic nervous system benign neoplasm 10.2 ENO2 MYCN
8 nodular ganglioneuroblastoma 10.2 ENO2 MYCN
9 head injury 10.2 CHAT ENO2
10 primitive neuroectodermal tumor of the cervix uteri 10.2 ENO2 PTPRC
11 dermis tumor 10.2 B3GAT1 PDGFB
12 vulvar sarcoma 10.2 EWSR1 PTPRC
13 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.2 B3GAT1 PTPRC
14 hodgkin's lymphoma, mixed cellularity 10.2 B3GAT1 PTPRC
15 conventional fibrosarcoma 10.2 ENO2 PTPRC
16 sarcomatosis 10.2 EWSR1 WT1
17 endometrial small cell carcinoma 10.2 ENO2 PTPRC
18 renal adenoma 10.2 B3GAT1 WT1
19 epithelial predominant wilms' tumor 10.1 B3GAT1 WT1
20 bladder sarcoma 10.1 CD99 EWSR1
21 marcus gunn phenomenon 10.1 CHAT MYC
22 epithelioid cell melanoma 10.1 ENO2 WT1
23 tendinitis 10.1 PDGFB PHB2
24 olfactory neuroblastoma 10.1 ENO2 EWSR1 PTPRC
25 cerebral primitive neuroectodermal tumor 10.1 ENO2 MYC MYCN
26 medullomyoblastoma 10.1 ENO2 MYC MYCN
27 gastric small cell carcinoma 10.1 B3GAT1 ENO2 PTPRC
28 autonomic nervous system neoplasm 10.1 ENO2 MYC MYCN
29 rhabdoid cancer 10.1 ENO2 EWSR1 WT1
30 peripheral nervous system neoplasm 10.1 ENO2 MYC MYCN
31 central nervous system cancer 10.1 ENO2 MYC MYCN
32 cauda equina neoplasm 10.1 ENO2 EWSR1 WT1
33 desmoplastic small round cell tumor 10.1 ENO2 EWSR1 WT1
34 chondrosarcoma, extraskeletal myxoid 10.1 ENO2 EWSR1 WT1
35 muscle cancer 10.1 ENO2 EWSR1 WT1
36 kidney clear cell sarcoma 10.1 ENO2 WT1
37 clear cell sarcoma 10.1 ENO2 EWSR1 WT1
38 nervous system disease 10.1 CHAT ENO2 MYCN
39 ovarian lymphoma 10.1 MYC PTPRC
40 kidney benign neoplasm 10.1 B3GAT1 WT1
41 small cell cancer of the lung 10.1 ENO2 MYC MYCN
42 hypertrichosis universalis congenita, ambras type 10.1 MYC PHB2
43 malignant histiocytosis 10.1 MYB MYC PDGFB
44 venous hemangioma 10.1 MYC WT1
45 adult fibrosarcoma 10.1 PDGFB WT1
46 askin's tumor 10.0 ENO2 EWSR1 MYC MYCN
47 nervous system cancer 10.0 ENO2 EWSR1 MYC MYCN
48 pericardium cancer 10.0 CD99 ENO2 MYCN
49 rhabdomyosarcoma 10.0 ENO2 EWSR1 MYCN PTPRC
50 breast adenomyoepithelioma 10.0 CD99 ENO2

Graphical network of the top 20 diseases related to Bone Ewing's Sarcoma:



Diseases related to Bone Ewing's Sarcoma

Symptoms & Phenotypes for Bone Ewing's Sarcoma

UMLS symptoms related to Bone Ewing's Sarcoma:


fever, pain

MGI Mouse Phenotypes related to Bone Ewing's Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.1 CHAT ENO2 ETS1 FES LONP1 MYB
2 cardiovascular system MP:0005385 10.01 CHAT ETS1 FES MYB MYC MYCN
3 mortality/aging MP:0010768 9.93 B3GAT1 CHAT ETS1 FES LONP1 MYB
4 embryo MP:0005380 9.91 ETS1 LONP1 MYB MYC MYCN PDGFB
5 liver/biliary system MP:0005370 9.8 FES MYB MYC MYCN PDGFB PTPRC
6 no phenotypic analysis MP:0003012 9.43 MYB MYC MYCN PDGFB PTPRC WT1
7 reproductive system MP:0005389 9.23 B3GAT1 CHAT FES MYC MYCN PDGFB

Drugs & Therapeutics for Bone Ewing's Sarcoma

Drugs for Bone Ewing's Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 2,Not Applicable 57-22-7, 2068-78-2 5978
2
Cyclophosphamide Approved, Investigational Phase 2,Not Applicable 6055-19-2, 50-18-0 2907
3
Topotecan Approved, Investigational Phase 2,Not Applicable 123948-87-8, 119413-54-6 60700
4
Bevacizumab Approved, Investigational Phase 2 216974-75-3
5
Doxorubicin Approved, Investigational Phase 2,Not Applicable 23214-92-8 31703
6
Ifosfamide Approved Phase 2,Not Applicable 3778-73-2 3690
7
Etoposide Approved Phase 2,Not Applicable 33419-42-0 36462
8
Lenograstim Approved, Investigational Phase 2,Not Applicable 135968-09-1
9
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
10
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
11
Everolimus Approved Phase 2 159351-69-6 6442177
12
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
13
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
14
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
15
Mechlorethamine Approved, Investigational Phase 2,Not Applicable 51-75-2 4033
16
Doxil Approved June 1999 Phase 2,Not Applicable 31703
17 Immunosuppressive Agents Phase 2,Not Applicable
18 Antirheumatic Agents Phase 2,Not Applicable
19 Antineoplastic Agents, Alkylating Phase 2,Not Applicable
20 Immunologic Factors Phase 2,Not Applicable
21 topoisomerase I inhibitors Phase 2,Not Applicable
22 Alkylating Agents Phase 2,Not Applicable
23 Antibodies Phase 2
24 Topoisomerase Inhibitors Phase 2,Not Applicable
25 Immunoglobulins Phase 2
26 Antibodies, Monoclonal Phase 2
27 Antimitotic Agents Phase 2,Not Applicable
28 Antineoplastic Agents, Phytogenic Phase 2,Not Applicable
29 Angiogenesis Modulating Agents Phase 2
30 Angiogenesis Inhibitors Phase 2
31
Isophosphamide mustard Phase 2,Not Applicable 0
32 Anti-Bacterial Agents Phase 2,Not Applicable
33 Antibiotics, Antitubercular Phase 2,Not Applicable
34 Etoposide phosphate Phase 2,Not Applicable
35 Anti-Infective Agents Phase 2,Early Phase 1
36 Antifungal Agents Phase 2
37 Protein Kinase Inhibitors Phase 2
38 Protective Agents Phase 2
39 Cardiotonic Agents Phase 2
40 razoxane Phase 2
41
Dactinomycin Approved, Investigational 50-76-0 457193 2019
42
Alovudine Investigational Early Phase 1 25526-93-6
43 Antiviral Agents Early Phase 1
44 Fluorodeoxyglucose F18 Early Phase 1
45 Radiopharmaceuticals Early Phase 1
46 Fluorides Early Phase 1
47 Nucleic Acid Synthesis Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Vincristine Sulfate, Topotecan Hydrochloride, and Cyclophosphamide With or Without Bevacizumab in Treating Young Patients With Refractory or First Recurrent Extracranial Ewing Sarcoma Completed NCT00516295 Phase 2 topotecan hydrochloride;vincristine sulfate;cyclophosphamide
2 A Phase II Study Evaluating Efficacy and Safety of Regorafenib in Patients With Metastatic Bone Sarcomas Recruiting NCT02389244 Phase 2 Regorafenib;Placebo
3 Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell Tumors Active, not recruiting NCT01946529 Phase 2 vincristine;doxorubicin;cyclophosphamide;ifosfamide;etoposide;temozolomide;temsirolimus;bevacizumab;sorafenib
4 Combination Chemotherapy and Dexrazoxane Followed by Surgery and Radiation Therapy in Treating Patients With Advanced Soft Tissue Sarcoma or Recurrent Bone Sarcoma Terminated NCT00544778 Phase 2 dexrazoxane hydrochloride;doxorubicin hydrochloride;ifosfamide;irinotecan hydrochloride
5 Two Regimens of Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed Localized Ewing Sarcoma Family of Tumors Completed NCT00618813 Not Applicable etoposide;ifosfamide;doxorubicin hydrochloride;cyclophosphamide;vincristine sulfate;topotecan hydrochloride
6 18F-FLT Positron Emission Tomography and Diffusion-Weighted Magnetic Resonance Imaging in Planning Surgery and Radiation Therapy and Measuring Response in Patients With Newly Diagnosed Ewing Sarcoma Completed NCT01825902 Early Phase 1 fluorine F 18 fluorothymidine
7 Evaluating Dactinomycin and Vincristine in Young Patients With Cancer Completed NCT00674193
8 Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed By Stem Cell Rescue in Treating Patients With Poor-Risk Ewing Sarcoma Withdrawn NCT01795430 Not Applicable etoposide;ifosfamide;topotecan hydrochloride;busulfan;melphalan

Search NIH Clinical Center for Bone Ewing's Sarcoma

Genetic Tests for Bone Ewing's Sarcoma

Anatomical Context for Bone Ewing's Sarcoma

MalaCards organs/tissues related to Bone Ewing's Sarcoma:

41
Bone, Lung, Kidney, Heart, Cervix, Myeloid, Eye

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Ewing's Sarcoma:

19
Bone

Publications for Bone Ewing's Sarcoma

Articles related to Bone Ewing's Sarcoma:

(show top 50) (show all 79)
# Title Authors Year
1
A systematic review of optimal treatment strategies for localized Ewing's sarcoma of bone after neo-adjuvant chemotherapy. ( 26979636 )
2016
2
Evidence-based guideline recommendations on treatment strategies for localized Ewing's sarcoma of bone following neo-adjuvant chemotherapy. ( 27312034 )
2016
3
Ewing's sarcoma of bone tumor cells produces MCSF that stimulates monocyte proliferation in a novel mouse model of Ewing's sarcoma of bone. ( 26051470 )
2015
4
Ewing's sarcoma of bone. ( 25070232 )
2014
5
Bee-sting, a non-resolving wound and a progressive mass over the right eye preceding the ultimate diagnosis of frontal bone Ewing's sarcoma. ( 22761215 )
2012
6
Risk adapted chemotherapy for localised Ewing's sarcoma of bone: the French EW93 study. ( 22516209 )
2012
7
Health related quality of life and late side effects of long-term survivors of Ewing's sarcoma of bone. ( 22006761 )
2011
8
Role of radiation therapy in the multidisciplinary management of Ewing's Sarcoma of bone in pediatric patients: An effective treatment for local control. ( 24376965 )
2011
9
Long-lasting multiagent chemotherapy in adult high-risk Ewing's sarcoma of bone. ( 18989798 )
2009
10
The differential effects of the radioprotectant drugs amifostine and sodium selenite treatment in combination with radiation therapy on constituent bone cells, Ewing's sarcoma of bone tumor cells, and rhabdomyosarcoma tumor cells in vitro. ( 18473385 )
2008
11
Ewing's sarcoma of bone: ESMO clinical recommendations for diagnosis, treatment and follow-up. ( 17491059 )
2007
12
Ewing's sarcoma of bone: the detection of specific transcripts in a large, consecutive series of formalin-fixed, decalcified, paraffin-embedded tissue samples using the reverse transcriptase-polymerase chain reaction. ( 16487358 )
2006
13
ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of Ewing's sarcoma of bone. ( 15888765 )
2005
14
Surgery for lung metastases in Ewing's sarcoma of bone. ( 14736525 )
2004
15
Incidental detection of microfilariae in aspirates from Ewing's sarcoma of bone. ( 12827713 )
2003
16
ESMO Minimum Clinical Recommendations for diagnosis, treatment and follow-up of Ewing's sarcoma of bone. ( 12881370 )
2003
17
The treatment of Ewing's sarcoma of bone at the University of Florida: 1969 to 1998. ( 11953620 )
2002
18
Ewing's sarcoma of bone: relation between clinical characteristics and staging. ( 11295079 )
2001
19
Primary petrous bone Ewing's sarcoma. ( 10889890 )
2000
20
Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli. ( 10623687 )
2000
21
Neoadjuvant chemotherapy for Ewing's sarcoma of bone in patients older than thirty-nine years. ( 10752664 )
2000
22
Overexpression of p53 protein in primary Ewing's sarcoma of bone: relationship to tumour stage, response and prognosis. ( 10098757 )
1999
23
Prognostic significance of serum LDH in Ewing's sarcoma of bone. ( 10373661 )
1999
24
Expression of neural cell adhesion molecules and neurofilament protein isoforms in Ewing's sarcoma of bone and soft tissue sarcomas other than rhabdomyosarcoma. ( 10534169 )
1999
25
Neoadjuvant chemotherapy for Ewing's sarcoma of bone: no benefit observed after adding ifosfamide and etoposide to vincristine, actinomycin, cyclophosphamide, and doxorubicin in the maintenance phase--results of two sequential studies. ( 9506366 )
1998
26
Quantitative analysis of the plain radiographic appearance of Ewing's sarcoma of bone. ( 9007649 )
1997
27
The Impact of Radiotherapy Dose on Local Control of Ewing's Sarcoma of Bone. ( 18521198 )
1997
28
Long-term follow-up for patients with Ewing's sarcoma of bone treated with adjuvant and neoadjuvant chemotherapy. ( 21590179 )
1997
29
Ewing's sarcoma of bone--a study of 71 cases by fine needle aspiration cytology. ( 8854626 )
1996
30
Comparison of Ewing's sarcoma of bone and peripheral neuroepithelioma. ( 7487413 )
1995
31
Is neuro-ectodermal differentiation of Ewing's sarcoma of bone associated with an unfavourable prognosis? ( 7786593 )
1995
32
A comparative study of nuclear morphometry and proliferating activity in neuroectodermal tumors of bone and Ewing's sarcoma of bone. ( 8548592 )
1995
33
Ewing's sarcoma of bone: oncologic and functional results. ( 8551735 )
1995
34
Comparison of Ewing's sarcoma of bone and peripheral neuroepithelioma. An immunocytochemical and ultrastructural analysis of two primitive neuroectodermal neoplasms. ( 8204006 )
1994
35
Monitoring the effect of chemotherapy in Ewing's sarcoma of bone with MR imaging. ( 7824974 )
1994
36
Classification of histopathologic changes following chemotherapy in Ewing's sarcoma of bone. ( 7824975 )
1994
37
Negative 123-meta-iodobenzyl-guanidine imaging in Ewing's sarcoma of bone. ( 8202035 )
1994
38
No advantages in the addition of ifosfamide and VP-16 to the standard four-drug regimen in the maintenance phase of neoadjuvant chemotherapy of Ewing's sarcoma of bone: results of two sequential studies. ( 8229153 )
1993
39
Comparison of cell surface antigen HBA71 (p30/32MIC2), neuron-specific enolase, and vimentin in the immunohistochemical analysis of Ewing's sarcoma of bone. ( 1497115 )
1992
40
Ifosfamide plus etoposide in newly diagnosed Ewing's sarcoma of bone. ( 1403056 )
1992
41
(Sub)periosteal Ewing's sarcoma of bone. ( 1729262 )
1992
42
Local control and function after twice-a-day radiotherapy for Ewing's sarcoma of bone. ( 1938560 )
1991
43
Long-term follow-up of Ewing's sarcoma of bone treated with combined modality therapy. ( 1995522 )
1991
44
Long-term follow-up of Ewing's sarcoma of bone. ( 1995554 )
1991
45
Combined therapy of localized Ewing's sarcoma of bone: analysis of results in 100 patients. ( 2254107 )
1990
46
Multimodal therapy for the management of nonpelvic, localized Ewing's sarcoma of bone: intergroup study IESS-II. ( 2099751 )
1990
47
Multimodal therapy for the management of primary, nonmetastatic Ewing's sarcoma of bone: a long-term follow-up of the First Intergroup study. ( 2213103 )
1990
48
Ewing's sarcoma of bone. ( 2092766 )
1990
49
Therapy for localized Ewing's sarcoma of bone. ( 2915236 )
1989
50
Ewing's sarcoma of bone and soft tissues. ( 2655527 )
1989

Variations for Bone Ewing's Sarcoma

Expression for Bone Ewing's Sarcoma

Search GEO for disease gene expression data for Bone Ewing's Sarcoma.

Pathways for Bone Ewing's Sarcoma

GO Terms for Bone Ewing's Sarcoma

Cellular components related to Bone Ewing's Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.4 CD99 CENPV CHAT ENO2 ETS1 EWSR1

Biological processes related to Bone Ewing's Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.55 ETS1 MYC MYCN PDGFB WT1
2 response to wounding GO:0009611 9.5 ETS1 MYC PDGFB
3 positive regulation of smooth muscle cell migration GO:0014911 9.46 MYC PDGFB
4 positive regulation of glial cell proliferation GO:0060252 9.43 MYB MYC
5 positive regulation of smooth muscle cell proliferation GO:0048661 9.43 MYB MYC PDGFB
6 positive regulation of DNA biosynthetic process GO:2000573 9.4 MYC PDGFB
7 hypothalamus development GO:0021854 9.37 ETS1 MYC
8 positive regulation of transcription, DNA-templated GO:0045893 9.1 ETS1 MYB MYC MYCN PDGFB WT1
9 positive regulation of DNA methylation GO:1905643 8.96 MYC WT1

Molecular functions related to Bone Ewing's Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001077 9.02 ETS1 MYB MYC MYCN WT1

Sources for Bone Ewing's Sarcoma

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
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32 HPO
33 ICD10
34 ICD10 via Orphanet
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44 MeSH
45 MESH via Orphanet
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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