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MCID: BNF002
MIFTS: 46

Bone Fracture

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Bone Fracture

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MalaCards integrated aliases for Bone Fracture:

Name: Bone Fracture 38 55

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


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Summaries for Bone Fracture

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MalaCards based summary : Bone Fracture is related to osteofibrous dysplasia and osteoporosis. An important gene associated with Bone Fracture is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Pathways in cancer and G-protein signaling RAC1 in cellular process. The drugs Teriparatide and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Adipose, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

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Related Diseases for Bone Fracture

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Diseases related to Bone Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 osteofibrous dysplasia 31.0 BGLAP BMP2 TGFB1
2 osteoporosis 29.7 BGLAP BMP2 CRP TGFB1
3 differentiated thyroid carcinoma 29.4 BGLAP TGFB1
4 otosclerosis 29.2 BMP2 TGFB1
5 chronic kidney failure 29.1 BGLAP CRP TGFB1
6 spinal muscular atrophy, type i, with congenital bone fractures 12.6
7 spinal muscular atrophy with congenital bone fractures 2 12.5
8 prenatal-onset spinal muscular atrophy with congenital bone fractures 12.2
9 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 11.3
10 antley-bixler syndrome 11.2
11 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 11.1
12 hyper-ige recurrent infection syndrome, autosomal dominant 11.1
13 osteogenesis imperfecta, type ii 11.1
14 gnathodiaphyseal dysplasia 11.1
15 marsili syndrome 10.9
16 osteogenesis imperfecta, type i 10.9
17 mucolipidosis iii alpha/beta 10.9
18 multiple pterygium syndrome, lethal type 10.9
19 osteoporosis-pseudoglioma syndrome 10.9
20 pyle disease 10.9
21 spinal muscular atrophy, x-linked 2 10.9
22 lethal congenital contracture syndrome 2 10.9
23 osteogenesis imperfecta, type v 10.9
24 cerebroretinal microangiopathy with calcifications and cysts 1 10.9
25 neuropathy, hereditary sensory and autonomic, type vii 10.9
26 bruck syndrome 10.9
27 rickets 10.9
28 tetanus 10.9
29 osteitis fibrosa 10.9
30 cerebrospinal fluid leak 10.9
31 facial paralysis 10.2
32 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
33 camurati-engelmann disease 10.0 BGLAP TGFB1
34 brain injury 10.0
35 rapidly progressive glomerulonephritis 10.0 CRP TGFB1
36 head injury 10.0
37 calcific tendinitis 10.0 CRP TGFB1
38 heart valve disease 10.0 CRP TGFB1
39 nutritional deficiency disease 10.0 BGLAP CRP
40 bone inflammation disease 10.0 BGLAP CRP
41 end stage renal failure 10.0 CRP TGFB1
42 traumatic brain injury 10.0
43 juvenile rheumatoid arthritis 10.0 BGLAP CRP
44 intestinal disease 10.0 CRP STAT3
45 urinary system disease 9.9 CRP TGFB1
46 ossification of the posterior longitudinal ligament of spine 9.9 BGLAP BMP2
47 osseous heteroplasia, progressive 9.9 BGLAP BMP2
48 glucocorticoid-induced osteoporosis 9.9 BGLAP BMP2
49 ischemic bone disease 9.9 BGLAP BMP2
50 periodontitis 9.9 BGLAP CRP

Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to Bone Fracture
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Symptoms & Phenotypes for Bone Fracture

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GenomeRNAi Phenotypes related to Bone Fracture according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.44 BGLAP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.44 CRP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.44 STAT3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.44 BGLAP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 BGLAP CRP STAT3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.44 BGLAP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.44 STAT3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.44 STAT3
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.44 STAT3
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.44 CRP
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.44 CRP
Sources

Drugs & Therapeutics for Bone Fracture

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Drugs for Bone Fracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 824)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Teriparatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52232-67-4 16133850
2
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
5
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
6
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6 23925
7
Etidronic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable 7414-83-7, 2809-21-4 3305
8
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Not Applicable 1197-18-8 5526
9
Levobupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27262-47-1 92253
10
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
11
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84057-95-4 175805 71273
12
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 471-34-1
13
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1 113775-47-6 68602 5311068
14
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-27-2 5288826
15
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
16
Cilostazol Approved, Investigational Phase 4,Not Applicable 73963-72-1 2754
17
Clopidogrel Approved Phase 4,Not Applicable 113665-84-2, 120202-66-6 60606
18
Cefmetazole Approved, Investigational Phase 4 56796-20-4 42008
19
Celecoxib Approved, Investigational Phase 4,Phase 3,Not Applicable 169590-42-5 2662
20
Ketorolac Approved Phase 4,Phase 3,Phase 2,Not Applicable 66635-83-4, 74103-06-3 3826
21
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 329-65-7 838
22
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-43-4 5816
23
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 76-42-6 5284603
24
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
25
Linagliptin Approved Phase 4 668270-12-0 10096344
26
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112809-51-5 3902
27
Zoledronic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 118072-93-8 68740
28
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
29
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
30
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068
31
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
32
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable 50-23-7 5754
33
Etomidate Approved Phase 4 33125-97-2 667484 36339
34
Hydrocortisone acetate Approved, Vet_approved Phase 4,Not Applicable 50-03-3
35
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Not Applicable 59467-70-8 4192
36
Alendronate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 66376-36-1, 121268-17-5 2088
37 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38
Tocopherol Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 1406-66-2 14986
39
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
40
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 437-38-7 3345
41
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
42
Indapamide Approved Phase 4 26807-65-8 3702
43
Emtricitabine Approved, Investigational Phase 4,Phase 2 143491-57-0 60877
44
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Not Applicable 28523-86-6 5206
45
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
46
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable,Early Phase 1 6740-88-1 3821
47
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
48
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 302-25-0
49
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-24-8 5755
50
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 83-43-2 6741

Interventional clinical trials:

(show top 50) (show all 3667)
# Name Status NCT ID Phase Drugs
1 Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail Unknown status NCT01437176 Phase 4
2 Ankle Fractures Treated With Teriparatide Unknown status NCT02955056 Phase 4 Forsteo
3 The Use of Teriparatide as an Adjunctive Therapy for the Treatment of Jones Fractures Unknown status NCT01173081 Phase 4 Teriparatide;Placebo
4 Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture Unknown status NCT00829725 Phase 4
5 NovaLign Intramedullary Fixation System (IFS) for the Treatment of Humeral Fractures Unknown status NCT00969839 Phase 4
6 Obturator and Femoral Nerve Block in Patients With Hip Fracture Unknown status NCT02540837 Phase 4 Bupivacaine;Saline
7 Parathyroid Hormone for the Treatment of Humerus Fractures Unknown status NCT01687374 Phase 4 1-84 parathyroid hormone;Placebo
8 Single Dose of Dexamethasone in Femur Fractures Unknown status NCT01550146 Phase 4 Dexamethasone acetate;Placebo
9 Outcome Comparison Between PFNA and InterTAN Unknown status NCT01797237 Phase 4
10 Hematoma Block for Reduction of Distal Radius Fractures Unknown status NCT02129270 Phase 4 Lidocaine HCl 2% .;Lidocaine HCl 1%
11 The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery Unknown status NCT00162617 Phase 4 Red blood cell transfusion
12 Efficacy and Safety of Intravenous Iron Sucrose in Patients With Hip Fracture to Prevent Perioperative Anemia Unknown status NCT01084122 Phase 4 Iron sucrose
13 Short-term Functional Recovery Between Early- and Late Bisphosphonate Treatment Following Hemiarthroplasty Unknown status NCT02148848 Phase 4 Risedronate
14 Comparing Weight Bearing After Intramedullary Fixation Devices for the Proximal Femur Fracture Unknown status NCT01509859 Phase 4
15 W-Shaped Acetabular Angular Plate (WAAP) Versus Reconstruction Plate Unknown status NCT02327949 Phase 4
16 Dose Finding Study for Continuous Spinal Anaesthesia Unknown status NCT01680120 Phase 4
17 Tranexamic Acid in Intertrochanteric and Subtrochanteric Femur Fractures Unknown status NCT02580227 Phase 4 Tranexamic Acid
18 A Dose Finding Study for Pain Relief of a Broken Hip Unknown status NCT00926666 Phase 4 Levobupivacaine
19 Study of Nerve Block Anesthesia for Surgery of Hip Fracture in the Elderly Unknown status NCT02104908 Phase 4
20 Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures Unknown status NCT01482858 Phase 4
21 Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Unknown status NCT01934049 Phase 4 Total Intravenous Anesthesia and Peripheral nerve blocks
22 Intrathecal Morphine,Femoral Nerve Block,Periarticular Bupivacaine Infiltration for Pain After Intramedullary Hip Screw Unknown status NCT01219088 Phase 4 Bupivacaine, morphine
23 Monopolar Electrosurgery Versus Ultrasound Scissors in Thoracoscopic Ventral Spondylodesis Unknown status NCT00941213 Phase 4
24 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
25 The Effect of Periarticular Multi-Drug Regimen on Pain After Partial Hip Replacement Unknown status NCT01112436 Phase 4 periarticular injection of multidrug regimen;none of medication preoperatively and intraoperatively
26 Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo Unknown status NCT01945788 Phase 4 Teriparatide (rDNA origin)
27 A One-year Randomized Controlled Trial Evaluating the Impact of Pioglitazone Versus Linagliptin on Bone Turnover Markers Unknown status NCT02429232 Phase 4 Pioglitazone;Linagliptin
28 Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy (PreFace) Unknown status NCT01908556 Phase 4 Letrozole
29 The Effect of Zoledronic Acid to Bone Fusion and Bone Metabolism of Patients With Lumbar Degenerative Disease After Lumbar Interbody Fusion Unknown status NCT01310465 Phase 4 zoledronic acid;sodium chloride
30 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
31 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
32 Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
33 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
34 Bone Turnover in Type 2 Diabetes Patients Unknown status NCT00732121 Phase 4 Sitagliptin;Placebo
35 Manually Versus Digitally Fabricated Removable Partial Dentures Unknown status NCT01191073 Phase 4
36 Efficacy and Safety of Brand Versus Generic Alendronate for Osteoporosis Treatment Unknown status NCT02371252 Phase 4 Generic alendronate
37 Determination of Vitamin D Dose to Maintain Sufficiency Amongst Indian and Malay Women in the Tropics Unknown status NCT02389179 Phase 4 Vitamin D3
38 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
39 the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Ankle Unknown status NCT02519881 Phase 4
40 Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients Unknown status NCT00912938 Phase 4 zoledronic acid
41 Intranasal Fentanyl for Pain Management Unknown status NCT00882960 Phase 4 intravenous fentanyl;intra-nasal fentanyl
42 Comparison of Efficacy and Safety of Microfracture and Modified Microfracture Unknown status NCT02539030 Phase 4
43 The Hypertension in the Very Elderly Trial (HYVET) Unknown status NCT00122811 Phase 4 Indapamide SR 1.5mg; Perindopril 2-4mg
44 Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss Unknown status NCT02322099 Phase 4 Alendronate;Placebo;Tenofovir disoproxil
45 Study Evaluating InductOs in Diaphyseal Tibia Fractures Completed NCT00161616 Phase 4 InductOs
46 Outcomes of Operative Treatment of Unstable Ankle Fracture - Comparison Between Metallic and Biodegradable Implants Completed NCT01431560 Phase 4
47 Treatment of Acetabular Posterior Wall Fracture With Anatomical Locking Plate Completed NCT01437150 Phase 4
48 Evaluation of the Effects of Less Invasive Stabilization System (LISS) Plating Techniques in Distal Femoral Fractures Completed NCT00552331 Phase 4
49 Allomatrix Injectable Putty in Distal Radius Fractures Completed NCT00274378 Phase 4
50 Efficacy of DBM on Fractures of the Shinbone (Tibia) Completed NCT00299052 Phase 4

Search NIH Clinical Center for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bone Fracture cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bone Fracture:
ALLOB�, allogeneic osteoblasts for bone disorders
Bone marrow-derived mesenchymal stem cells for treatment of atrophic nonunion fractures
Map3�, multipotent adult progenitor cel-based bone graft for bone injury
Ovation�, mesenchymal stem cells for bone repair
PREOB�, autologous osteoblasts for bone disorders
Stromal vascular fraction cells for osteoporotic bone fractures
Embryonic/Adult Cultured Cells Related to Bone Fracture:
Bone marrow-derived mesenchymal stem cells PMIDs: 23180104
Bone marrow-derived adherent progenitor cells (MultiStem)
Stromal vascular fraction cells PMIDs: 21605897 16488036
Sources

Genetic Tests for Bone Fracture

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Anatomical Context for Bone Fracture

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MalaCards organs/tissues related to Bone Fracture:

41
Bone, Kidney, Lung, Brain, Bone Marrow, Liver, Endothelial
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
# Tissue Anatomical CompartmentCell Relevance
1 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
Sources

Publications for Bone Fracture

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Articles related to Bone Fracture:

(show top 50) (show all 804)
# Title Authors Year
1
Otopathology of Unilateral Cochlear Implantation in Patients With Bilateral Temporal Bone Fracture. ( 30531637 )
2019
2
Vestibular Traumatic Neuroma Following Temporal Bone Fracture. ( 30531646 )
2019
3
The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings. ( 29356996 )
2018
4
Mineralized collagen fibril network spatial arrangement influences cortical bone fracture behavior. ( 29137726 )
2018
5
Pain Intensity and Risk of Bone Fracture in Children With Minor Extremity Injuries. ( 29369266 )
2018
6
Temporary inhibition of the plasminogen activator inhibits periosteal chondrogenesis and promotes periosteal osteogenesis during appendicular bone fracture healing. ( 29680264 )
2018
7
New Insights in Understanding and Treating Bone Fracture Pain. ( 29948820 )
2018
8
Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice. ( 29765320 )
2018
9
Association Between Inhaled Corticosteroid Use and Bone Fracture in Children With Asthma. ( 29131874 )
2018
10
Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover. ( 29931664 )
2018
11
Estrogen receptor I+- (ERI+), but not ERI^-signaling, is crucially involved in mechanostimulation of bone fracture healing by whole-body vibration. ( 29367057 )
2018
12
Can quantitative computed tomography detect bone morphological changes associated with catastrophic proximal sesamoid bone fracture in Thoroughbred racehorses? ( 29758110 )
2018
13
A CONCOMITANT BONE FRACTURE DELAYS COGNITIVE RECOVERY FROM TRAUMATIC BRAIN INJURY. ( 29787539 )
2018
14
Pronounced femur malunion after pathological bone fracture due to a simple bone cyst in the shaft of the femur, treated using Ilizarov fixation: a case report. ( 29925426 )
2018
15
Anabolic Strategies to Augment Bone Fracture Healing. ( 29725836 )
2018
16
Bariatric surgery increases risk of bone fracture. ( 29713829 )
2018
17
Effect of ultrasound on bone fracture healing: A computational bioregulatory model. ( 29975857 )
2018
18
Pseudo-malignant osteolysis of the pelvis: Unusual pattern of pubic bone fracture. ( 29709697 )
2018
19
Dietary fat, saturated fatty acid, and monounsaturated fatty acid intakes and risk of bone fracture: a systematic review and meta-analysis of observational studies. ( 29947872 )
2018
20
Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing. ( 29146294 )
2018
21
Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP<sub>1</sub> receptor antagonist and in vivo studies in a bone fracture model. ( 29934246 )
2018
22
Optimal administration frequency and dose of teriparatide for acceleration of biomechanical healing of long-bone fracture in a mouse model. ( 29721806 )
2018
23
The Impact of Type 2 Diabetes on Bone Fracture Healing. ( 29416527 )
2018
24
Usefulness of indirect open reduction via a transconjunctival approach for the treatment of nasal bone fracture associated with orbital blowout fracture. ( 29788695 )
2018
25
Assessment of cortical bone fracture resistance curves by fusing artificial neural networks and linear regression. ( 29383945 )
2018
26
Accuracy in Screw Selection in a Cadaveric, Small-Bone Fracture Model. ( 29801935 )
2018
27
Application of resampling techniques to improve the quality of survival analysis risk curves for human frontal bone fracture. ( 29753560 )
2018
28
Otopathologic Changes in the Cochlea following Head Injury without Temporal Bone Fracture. ( 29890895 )
2018
29
Impact of Bone Fracture on Ischemic Stroke Recovery. ( 29786644 )
2018
30
Effects of obesity on the healing of bone fracture in mice. ( 29880016 )
2018
31
Development of controlled drug delivery systems for bone fracture-targeted therapeutic delivery: A review. ( 29471078 )
2018
32
Forces associated with launch into space do not impact bone fracture healing. ( 29475520 )
2018
33
Simplified Access for Reduction and Fixation of a Frontal Bone Fracture. ( 29481494 )
2018
34
Systematic review of hearing loss after traumatic brain injury without associated temporal bone fracture. ( 29506762 )
2018
35
MicroRNA-218 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells and Accelerates Bone Fracture Healing. ( 29523928 )
2018
36
Panfacial bone fracture: cephalic to caudal. ( 29609426 )
2018
37
The efficacy of mobile application use on recall of surgical risks in nasal bone fracture reduction surgery. ( 29609431 )
2018
38
Down-regulation of LGR6 promotes bone fracture recovery using bone marrow stromal cells. ( 29625528 )
2018
39
Novel, cost-effective, Cu-doped calcium silicate nanoparticles for bone fracture intervention: Inherent bioactivity and in vivo performance. ( 29656599 )
2018
40
LAG-3 Represents a Marker of CD4+ T Cells with Regulatory Activity in Patients with Bone Fracture. ( 29671649 )
2018
41
Application of mesenchymal stem cells to enhance non-union bone fracture healing. ( 29673055 )
2018
42
Role of Dynamic Loading on Early Stage of Bone Fracture Healing. ( 29987542 )
2018
43
A Model-Based Approach to Investigate the Effect of a Long Bone Fracture on Ultrasound Strain Elastography. ( 29994472 )
2018
44
Optimal bone fracture repair requires 24R,25-dihydroxyvitamin D3 and its effector molecule FAM57B2. ( 30010626 )
2018
45
Influence of Menopause on Inflammatory Cytokines during Murine and Human Bone Fracture Healing. ( 30013010 )
2018
46
PHOSPHO1 is essential for normal bone fracture healing: An Animal Study. ( 30034793 )
2018
47
Granulocyte-colony stimulating factor enhances bone fracture healing. ( 30036852 )
2018
48
Effect of radial shock wave therapy on long bone fracture repair. ( 30043570 )
2018
49
Risk factors for nonunion of bone fracture in pediatric patients: An inception cohort study of 237,033 fractures. ( 30075567 )
2018
50
Cerebral Edema and Neurological Recovery after Traumatic Brain Injury Are Worsened if Accompanied by a Concomitant Long Bone Fracture. ( 30084745 )
2018
Sources

Variations for Bone Fracture

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Expression for Bone Fracture

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Search GEO for disease gene expression data for Bone Fracture.
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Pathways for Bone Fracture

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Pathways related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Pathways in cancer 37
12.43 BMP2 STAT3 TGFB1
2
G-protein signaling RAC1 in cellular process 22
Show member pathways
 11.98 BMP2 STAT3 TGFB1
3
Interleukin-4 and 13 signaling 66
11.65 STAT3 TGFB1
4
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.62 BMP2 STAT3 TGFB1
5
Senescence and Autophagy in Cancer 1
11.61 BMP2 TGFB1
6
Visual Cycle in Retinal Rods 64
11.57 CRP STAT3
7
AGE-RAGE signaling pathway in diabetic complications 37
11.57 STAT3 TGFB1
8
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.54 STAT3 TGFB1
9
IL6-mediated signaling events 1
Show member pathways
 11.49 CRP STAT3
10
TGF-beta signaling pathway (KEGG) 37
11.47 BMP2 TGFB1
11
Elastic fibre formation 66
Show member pathways
 11.39 BMP2 TGFB1
12
IL-2 Gene Expression in Activated and Quiescent T-Cells 64
Show member pathways
 11.3 STAT3 TGFB1
13
TGF-beta Receptor Signaling (WikiPathways) 1
11.26 STAT3 TGFB1
14
Adipogenesis 1
11.25 BMP2 STAT3 TGFB1
15
Hepatitis C and Hepatocellular Carcinoma 1
11.18 STAT3 TGFB1
16
Notch-mediated HES/HEY network 1
11.14 BGLAP STAT3
17
Development_Thrombopoetin signaling via JAK-STAT pathway 22
10.97 CRP STAT3
18
Development_Leptin signaling via JAK/STAT and MAPK cascades 22
Show member pathways
 10.88 CRP STAT3
19
Dopaminergic Neurogenesis 1
10.85 STAT3 TGFB1
20
IL12 signaling mediated by STAT4 1
10.77 STAT3 TGFB1
21
Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway 1
10.58 BMP2 TGFB1
22
Interleukin-11 Signaling Pathway 1
10.44 BGLAP STAT3 TGFB1
Sources

GO Terms for Bone Fracture

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Cellular components related to Bone Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.96 BGLAP TGFB1
2 extracellular space GO:0005615 8.92 BGLAP BMP2 CRP TGFB1

Biological processes related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.82 BMP2 STAT3 TGFB1
2 negative regulation of cell proliferation GO:0008285 9.79 BMP2 STAT3 TGFB1
3 response to drug GO:0042493 9.71 BGLAP STAT3 TGFB1
4 positive regulation of cell migration GO:0030335 9.69 BMP2 STAT3 TGFB1
5 positive regulation of gene expression GO:0010628 9.67 BMP2 CRP STAT3 TGFB1
6 Notch signaling pathway GO:0007219 9.66 BMP2 TGFB1
7 response to ethanol GO:0045471 9.65 BGLAP STAT3
8 response to estradiol GO:0032355 9.65 STAT3 TGFB1
9 osteoblast differentiation GO:0001649 9.65 BGLAP BMP2
10 response to organic substance GO:0010033 9.64 STAT3 TGFB1
11 ossification GO:0001503 9.63 BGLAP BMP2
12 cell development GO:0048468 9.63 BMP2 TGFB1
13 aging GO:0007568 9.63 BGLAP STAT3 TGFB1
14 regulation of MAPK cascade GO:0043408 9.62 BMP2 TGFB1
15 SMAD protein signal transduction GO:0060395 9.62 BMP2 TGFB1
16 inner ear development GO:0048839 9.61 BMP2 TGFB1
17 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.6 BMP2 TGFB1
18 negative regulation of cell cycle GO:0045786 9.59 BMP2 TGFB1
19 positive regulation of epithelial to mesenchymal transition GO:0010718 9.58 BMP2 TGFB1
20 bone mineralization GO:0030282 9.58 BGLAP BMP2
21 response to organic cyclic compound GO:0014070 9.58 BGLAP STAT3 TGFB1
22 chondrocyte differentiation GO:0002062 9.57 BMP2 TGFB1
23 epithelial to mesenchymal transition GO:0001837 9.56 BMP2 TGFB1
24 inflammatory response GO:0006954 9.56 BMP2 CRP STAT3 TGFB1
25 acute-phase response GO:0006953 9.55 CRP STAT3
26 positive regulation of bone mineralization GO:0030501 9.52 BMP2 TGFB1
27 response to vitamin D GO:0033280 9.49 BGLAP TGFB1
28 positive regulation of superoxide anion generation GO:0032930 9.48 CRP TGFB1
29 pathway-restricted SMAD protein phosphorylation GO:0060389 9.43 BMP2 TGFB1
30 cellular response to organic cyclic compound GO:0071407 9.33 BMP2 STAT3 TGFB1
31 positive regulation of odontogenesis GO:0042482 9.32 BMP2 TGFB1
32 cellular response to growth factor stimulus GO:0071363 9.13 BGLAP BMP2 TGFB1
33 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.8 BMP2 STAT3 TGFB1

Molecular functions related to Bone Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 8.62 BMP2 TGFB1
Sources

Sources for Bone Fracture

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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