Aliases & Classifications for Bone Fracture

MalaCards integrated aliases for Bone Fracture:

Name: Bone Fracture 39 56 17

Classifications:



External Ids:

Summaries for Bone Fracture

MalaCards based summary : Bone Fracture is related to osteofibrous dysplasia and osteoporosis. An important gene associated with Bone Fracture is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Pathways in cancer and G-protein signaling RAC1 in cellular process. The drugs Ceftaroline fosamil and Teriparatide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Adipose, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

Related Diseases for Bone Fracture

Diseases related to Bone Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 osteofibrous dysplasia 31.0 BGLAP BMP2 TGFB1
2 osteoporosis 30.0 BGLAP BMP2 TGFB1
3 otosclerosis 29.4 BMP2 TGFB1
4 bone resorption disease 29.4 BGLAP BMP2
5 differentiated thyroid carcinoma 29.4 BGLAP TGFB1
6 chronic kidney failure 29.0 BGLAP CRP TGFB1
7 spinal muscular atrophy, type i, with congenital bone fractures 12.6
8 spinal muscular atrophy with congenital bone fractures 2 12.5
9 prenatal-onset spinal muscular atrophy with congenital bone fractures 12.2
10 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 11.3
11 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 1 11.2
12 antley-bixler syndrome 11.2
13 hyper-ige recurrent infection syndrome 1, autosomal dominant 11.1
14 osteogenesis imperfecta, type ii 11.1
15 gnathodiaphyseal dysplasia 11.1
16 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 2 11.1
17 marsili syndrome 10.9
18 osteogenesis imperfecta, type i 10.9
19 mucolipidosis iii alpha/beta 10.9
20 multiple pterygium syndrome, lethal type 10.9
21 osteoporosis-pseudoglioma syndrome 10.9
22 pyle disease 10.9
23 spinal muscular atrophy, x-linked 2 10.9
24 lethal congenital contracture syndrome 2 10.9
25 osteogenesis imperfecta, type v 10.9
26 cerebroretinal microangiopathy with calcifications and cysts 1 10.9
27 ewing sarcoma 10.9
28 neuropathy, hereditary sensory and autonomic, type vii 10.9
29 bruck syndrome 10.9
30 rickets 10.9
31 tetanus 10.9
32 osteitis fibrosa 10.9
33 cerebrospinal fluid leak 10.9
34 facial paralysis 10.2
35 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.1
36 head injury 10.1
37 camurati-engelmann disease 10.1 BGLAP TGFB1
38 brain injury 10.0
39 ossification of the posterior longitudinal ligament of spine 10.0 BGLAP BMP2
40 spinal muscular atrophy 10.0
41 muscular atrophy 10.0
42 osseous heteroplasia, progressive 10.0 BGLAP BMP2
43 glucocorticoid-induced osteoporosis 10.0 BGLAP BMP2
44 ischemic bone disease 10.0 BGLAP BMP2
45 ankylosis 10.0 BGLAP BMP2
46 bone remodeling disease 10.0 BGLAP BMP2
47 diabetes mellitus 10.0
48 traumatic brain injury 10.0
49 hyperparathyroidism 10.0
50 osteonecrosis 10.0 BGLAP BMP2

Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to Bone Fracture

Symptoms & Phenotypes for Bone Fracture

GenomeRNAi Phenotypes related to Bone Fracture according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.44 BGLAP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.44 CRP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.44 STAT3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.44 BGLAP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.44 BGLAP CRP STAT3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.44 BGLAP
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.44 STAT3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.44 STAT3
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.44 STAT3
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.44 CRP
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.44 CRP

Drugs & Therapeutics for Bone Fracture

Drugs for Bone Fracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 863)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ceftaroline fosamil Approved, Investigational Phase 4,Phase 1,Phase 2 229016-73-3
2
Teriparatide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52232-67-4 16133850
3
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
4
Parathyroid hormone Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 9002-64-6
5
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
6
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 1177-87-3
7
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
8
Iron Approved, Experimental Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6, 15438-31-0 23925 27284
9
Risedronate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 105462-24-6 5245
10
Etidronic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7414-83-7, 2809-21-4 3305
11
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Not Applicable 1197-18-8 5526
12
Levobupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27262-47-1 92253
13
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
14
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84057-95-4 71273 175805
15
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 471-34-1
16
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable,Early Phase 1 113775-47-6 68602 5311068
17
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-27-2 5288826
18
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 50-78-2 2244
19
Cilostazol Approved, Investigational Phase 4,Not Applicable 73963-72-1 2754
20
Clopidogrel Approved Phase 4,Not Applicable 120202-66-6, 113665-84-2 60606
21
Cefmetazole Approved, Investigational Phase 4 56796-20-4 42008
22
Celecoxib Approved, Investigational Phase 4,Phase 3,Not Applicable 169590-42-5 2662
23
Ketorolac Approved Phase 4,Phase 3,Not Applicable 66635-83-4, 74103-06-3 3826
24
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 329-65-7 838
25
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-43-4 5816
26
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1,Not Applicable 76-42-6 5284603
27
Silver sulfadiazine Approved, Vet_approved Phase 4,Phase 3 22199-08-2 441244
28
Linagliptin Approved Phase 4 668270-12-0 10096344
29
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
30
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112809-51-5 3902
31
Zoledronic Acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 118072-93-8 68740
32
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
33
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
34
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068
35
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
36
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable 50-23-7 5754
37
Etomidate Approved Phase 4 33125-97-2 36339 667484
38
Hydrocortisone acetate Approved, Vet_approved Phase 4,Not Applicable 50-03-3
39
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Not Applicable 59467-70-8 4192
40
Alendronate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 66376-36-1, 121268-17-5 2088
41
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
42
Tocopherol Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 1406-66-2 14986
43
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
44
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 437-38-7 3345
45
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
46
Indapamide Approved Phase 4 26807-65-8 3702
47
Emtricitabine Approved, Investigational Phase 4,Phase 2 143491-57-0 60877
48
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Not Applicable 28523-86-6 5206
49
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
50
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 6740-88-1 3821

Interventional clinical trials:

(show top 50) (show all 3781)
# Name Status NCT ID Phase Drugs
1 Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail Unknown status NCT01437176 Phase 4
2 Antibiotic Prophylaxis in Open Fractures Unknown status NCT02937181 Phase 4 Ceftaroline
3 Ankle Fractures Treated With Teriparatide Unknown status NCT02955056 Phase 4 Forsteo
4 The Use of Teriparatide as an Adjunctive Therapy for the Treatment of Jones Fractures Unknown status NCT01173081 Phase 4 Teriparatide;Placebo
5 Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture Unknown status NCT00829725 Phase 4
6 NovaLign Intramedullary Fixation System (IFS) for the Treatment of Humeral Fractures Unknown status NCT00969839 Phase 4
7 Obturator and Femoral Nerve Block in Patients With Hip Fracture Unknown status NCT02540837 Phase 4 Bupivacaine;Saline
8 Parathyroid Hormone for the Treatment of Humerus Fractures Unknown status NCT01687374 Phase 4 1-84 parathyroid hormone;Placebo
9 Single Dose of Dexamethasone in Femur Fractures Unknown status NCT01550146 Phase 4 Dexamethasone acetate;Placebo
10 Outcome Comparison Between PFNA and InterTAN Unknown status NCT01797237 Phase 4
11 Hematoma Block for Reduction of Distal Radius Fractures Unknown status NCT02129270 Phase 4 Lidocaine HCl 2% .;Lidocaine HCl 1%
12 The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery Unknown status NCT00162617 Phase 4 Red blood cell transfusion
13 Efficacy and Safety of Intravenous Iron Sucrose in Patients With Hip Fracture to Prevent Perioperative Anemia Unknown status NCT01084122 Phase 4 Iron sucrose
14 Short-term Functional Recovery Between Early- and Late Bisphosphonate Treatment Following Hemiarthroplasty Unknown status NCT02148848 Phase 4 Risedronate
15 Comparing Weight Bearing After Intramedullary Fixation Devices for the Proximal Femur Fracture Unknown status NCT01509859 Phase 4
16 W-Shaped Acetabular Angular Plate (WAAP) Versus Reconstruction Plate Unknown status NCT02327949 Phase 4
17 Dose Finding Study for Continuous Spinal Anaesthesia Unknown status NCT01680120 Phase 4
18 Tranexamic Acid in Intertrochanteric and Subtrochanteric Femur Fractures Unknown status NCT02580227 Phase 4 Tranexamic Acid
19 A Dose Finding Study for Pain Relief of a Broken Hip Unknown status NCT00926666 Phase 4 Levobupivacaine
20 Study of Nerve Block Anesthesia for Surgery of Hip Fracture in the Elderly Unknown status NCT02104908 Phase 4
21 Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures Unknown status NCT01482858 Phase 4
22 Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Unknown status NCT01934049 Phase 4 Total Intravenous Anesthesia and Peripheral nerve blocks
23 Intrathecal Morphine,Femoral Nerve Block,Periarticular Bupivacaine Infiltration for Pain After Intramedullary Hip Screw Unknown status NCT01219088 Phase 4 Bupivacaine, morphine
24 Monopolar Electrosurgery Versus Ultrasound Scissors in Thoracoscopic Ventral Spondylodesis Unknown status NCT00941213 Phase 4
25 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
26 The Effect of Periarticular Multi-Drug Regimen on Pain After Partial Hip Replacement Unknown status NCT01112436 Phase 4 periarticular injection of multidrug regimen;none of medication preoperatively and intraoperatively
27 Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo Unknown status NCT01945788 Phase 4 Teriparatide (rDNA origin)
28 The New Skin Stretching Device for Treatment of Limb Tension Wounds Unknown status NCT03141502 Phase 4
29 A One-year Randomized Controlled Trial Evaluating the Impact of Pioglitazone Versus Linagliptin on Bone Turnover Markers Unknown status NCT02429232 Phase 4 Pioglitazone;Linagliptin
30 Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy (PreFace) Unknown status NCT01908556 Phase 4 Letrozole
31 The Effect of Zoledronic Acid to Bone Fusion and Bone Metabolism of Patients With Lumbar Degenerative Disease After Lumbar Interbody Fusion Unknown status NCT01310465 Phase 4 zoledronic acid;sodium chloride
32 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
33 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
34 Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
35 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
36 Bone Turnover in Type 2 Diabetes Patients Unknown status NCT00732121 Phase 4 Sitagliptin;Placebo
37 Manually Versus Digitally Fabricated Removable Partial Dentures Unknown status NCT01191073 Phase 4
38 Efficacy and Safety of Brand Versus Generic Alendronate for Osteoporosis Treatment Unknown status NCT02371252 Phase 4 Generic alendronate
39 Determination of Vitamin D Dose to Maintain Sufficiency Amongst Indian and Malay Women in the Tropics Unknown status NCT02389179 Phase 4 Vitamin D3
40 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
41 the Efficacy and Safety of a Modified Microfracture Using Collagen Compared to Those of a Simple Microfracture in Ankle Unknown status NCT02519881 Phase 4
42 Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients Unknown status NCT00912938 Phase 4 zoledronic acid
43 Intranasal Fentanyl for Pain Management Unknown status NCT00882960 Phase 4 intravenous fentanyl;intra-nasal fentanyl
44 Comparison of Efficacy and Safety of Microfracture and Modified Microfracture Unknown status NCT02539030 Phase 4
45 The Hypertension in the Very Elderly Trial (HYVET) Unknown status NCT00122811 Phase 4 Indapamide SR 1.5mg; Perindopril 2-4mg
46 Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss Unknown status NCT02322099 Phase 4 Alendronate;Placebo;Tenofovir disoproxil
47 Study Evaluating InductOs in Diaphyseal Tibia Fractures Completed NCT00161616 Phase 4 InductOs
48 Outcomes of Operative Treatment of Unstable Ankle Fracture - Comparison Between Metallic and Biodegradable Implants Completed NCT01431560 Phase 4
49 Treatment of Acetabular Posterior Wall Fracture With Anatomical Locking Plate Completed NCT01437150 Phase 4
50 Evaluation of the Effects of Less Invasive Stabilization System (LISS) Plating Techniques in Distal Femoral Fractures Completed NCT00552331 Phase 4

Search NIH Clinical Center for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bone Fracture cell therapies at LifeMap Discovery.

Genetic Tests for Bone Fracture

Anatomical Context for Bone Fracture

MalaCards organs/tissues related to Bone Fracture:

42
Bone, Prostate, Breast, Bone Marrow, Kidney, Testes, Spinal Cord
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
# Tissue Anatomical CompartmentCell Relevance
1 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate

Publications for Bone Fracture

Articles related to Bone Fracture:

(show top 50) (show all 823)
# Title Authors Year
1
Novel, cost-effective, Cu-doped calcium silicate nanoparticles for bone fracture intervention: Inherent bioactivity and in vivo performance. ( 29656599 )
2019
2
Application of mesenchymal stem cells to enhance non-union bone fracture healing. ( 29673055 )
2019
3
Role of SMPD3 during Bone Fracture Healing and Regulation of Its Expression. ( 30530524 )
2019
4
Otopathology of Unilateral Cochlear Implantation in Patients With Bilateral Temporal Bone Fracture. ( 30531637 )
2019
5
Vestibular Traumatic Neuroma Following Temporal Bone Fracture. ( 30531646 )
2019
6
Risk of Ischemic Stroke After a Facial Bone Fracture in Elderly Patients. ( 30628941 )
2019
7
Targeted Endocrine Therapy: Design, Synthesis, and Proof-of-Principle of 17β-Hydroxysteroid Dehydrogenase Type 2 Inhibitors in Bone Fracture Healing. ( 30645111 )
2019
8
Psoralen accelerates bone fracture healing by activating both osteoclasts and osteoblasts. ( 30702934 )
2019
9
Effect of fentanyl nasal packing treatment on patients with acute postoperative pain after closed reduction of nasal bone fracture: a randomized double-blind controlled trial. ( 30734629 )
2019
10
Risk of bone fracture associated with sodium-glucose cotransporter-2 inhibitor treatment: a meta-analysis of randomized controlled trials. ( 30738154 )
2019
11
The effectiveness and safety of cervus and cucumis polypeptide injection in promoting fracture healing after bone fracture surgeries: Protocol for a systematic review and meta-analysis. ( 30762805 )
2019
12
Ultrasound Radiation Force for the Assessment of Bone Fracture Healing in Children: An In Vivo Pilot Study. ( 30813465 )
2019
13
Conservative versus Surgical Therapy in Managing Patients with Facial Nerve Palsy Due to the Temporal Bone Fracture. ( 30815211 )
2019
14
Effect of ultrasound on bone fracture healing: A computational mechanobioregulatory model. ( 30823826 )
2019
15
Perilymphatic fistula and pneumolabyrinth without temporal bone fracture: a rare entity. ( 30826783 )
2019
16
Optimal currents for electrical stimulation of bone fracture repair: A computational analysis including variations in frequency, tissue properties, and fracture morphology. ( 30830978 )
2019
17
Pericytes as a Source of Osteogenic Cells in Bone Fracture Healing. ( 30832329 )
2019
18
The effects of dynamic loading on bone fracture healing under Ilizarov Circular Fixators. ( 30835278 )
2019
19
Finger reduction of nasal bone fracture under local anesthesia: outcomes and patient reported satisfaction. ( 30840815 )
2019
20
The measurement of nose dimensions through the three-dimensional reformation images after nasal bone fracture. ( 30840816 )
2019
21
Bone fracture healing under Ilizarov fixator: influence of fixator configuration, fracture geometry and loading. ( 30869195 )
2019
22
Misplaced incus: an unusual complication of a temporal bone fracture. ( 30898967 )
2019
23
The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings. ( 29356996 )
2018
24
Mineralized collagen fibril network spatial arrangement influences cortical bone fracture behavior. ( 29137726 )
2018
25
Pain Intensity and Risk of Bone Fracture in Children With Minor Extremity Injuries. ( 29369266 )
2018
26
Temporary inhibition of the plasminogen activator inhibits periosteal chondrogenesis and promotes periosteal osteogenesis during appendicular bone fracture healing. ( 29680264 )
2018
27
New Insights in Understanding and Treating Bone Fracture Pain. ( 29948820 )
2018
28
Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice. ( 29765320 )
2018
29
Association Between Inhaled Corticosteroid Use and Bone Fracture in Children With Asthma. ( 29131874 )
2018
30
Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover. ( 29931664 )
2018
31
Estrogen receptor I+- (ERI+), but not ERI^-signaling, is crucially involved in mechanostimulation of bone fracture healing by whole-body vibration. ( 29367057 )
2018
32
Can quantitative computed tomography detect bone morphological changes associated with catastrophic proximal sesamoid bone fracture in Thoroughbred racehorses? ( 29758110 )
2018
33
A CONCOMITANT BONE FRACTURE DELAYS COGNITIVE RECOVERY FROM TRAUMATIC BRAIN INJURY. ( 29787539 )
2018
34
Pronounced femur malunion after pathological bone fracture due to a simple bone cyst in the shaft of the femur, treated using Ilizarov fixation: a case report. ( 29925426 )
2018
35
Anabolic Strategies to Augment Bone Fracture Healing. ( 29725836 )
2018
36
Bariatric surgery increases risk of bone fracture. ( 29713829 )
2018
37
Effect of ultrasound on bone fracture healing: A computational bioregulatory model. ( 29975857 )
2018
38
Pseudo-malignant osteolysis of the pelvis: Unusual pattern of pubic bone fracture. ( 29709697 )
2018
39
Dietary fat, saturated fatty acid, and monounsaturated fatty acid intakes and risk of bone fracture: a systematic review and meta-analysis of observational studies. ( 29947872 )
2018
40
Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing. ( 29146294 )
2018
41
Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP<sub>1</sub> receptor antagonist and in vivo studies in a bone fracture model. ( 29934246 )
2018
42
Optimal administration frequency and dose of teriparatide for acceleration of biomechanical healing of long-bone fracture in a mouse model. ( 29721806 )
2018
43
The Impact of Type 2 Diabetes on Bone Fracture Healing. ( 29416527 )
2018
44
Usefulness of indirect open reduction via a transconjunctival approach for the treatment of nasal bone fracture associated with orbital blowout fracture. ( 29788695 )
2018
45
Assessment of cortical bone fracture resistance curves by fusing artificial neural networks and linear regression. ( 29383945 )
2018
46
Accuracy in Screw Selection in a Cadaveric, Small-Bone Fracture Model. ( 29801935 )
2018
47
Application of resampling techniques to improve the quality of survival analysis risk curves for human frontal bone fracture. ( 29753560 )
2018
48
Otopathologic Changes in the Cochlea following Head Injury without Temporal Bone Fracture. ( 29890895 )
2018
49
Impact of Bone Fracture on Ischemic Stroke Recovery. ( 29786644 )
2018
50
Effects of obesity on the healing of bone fracture in mice. ( 29880016 )
2018

Variations for Bone Fracture

Expression for Bone Fracture

Search GEO for disease gene expression data for Bone Fracture.

Pathways for Bone Fracture

Pathways related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1 12.44 BMP2 STAT3 TGFB1
2
Show member pathways
11.98 BMP2 STAT3 TGFB1
3 11.64 STAT3 TGFB1
4
Show member pathways
11.62 BMP2 STAT3 TGFB1
5 11.6 BMP2 TGFB1
6 11.57 STAT3 TGFB1
7 11.56 CRP STAT3
8
Show member pathways
11.53 STAT3 TGFB1
9 11.5 BMP2 TGFB1
10
Show member pathways
11.39 BMP2 TGFB1
11
Show member pathways
11.3 STAT3 TGFB1
12 11.26 STAT3 TGFB1
13 11.25 BMP2 STAT3 TGFB1
14 11.18 STAT3 TGFB1
15 11.14 BGLAP STAT3
16 10.96 CRP STAT3
17
Show member pathways
10.88 CRP STAT3
18 10.85 STAT3 TGFB1
19 10.77 STAT3 TGFB1
20 10.58 BMP2 TGFB1
21 10.44 BGLAP STAT3 TGFB1

GO Terms for Bone Fracture

Cellular components related to Bone Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi lumen GO:0005796 8.96 BGLAP TGFB1
2 extracellular space GO:0005615 8.92 BGLAP BMP2 CRP TGFB1

Biological processes related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.82 BMP2 STAT3 TGFB1
2 negative regulation of cell proliferation GO:0008285 9.79 BMP2 STAT3 TGFB1
3 response to drug GO:0042493 9.71 BGLAP STAT3 TGFB1
4 positive regulation of cell migration GO:0030335 9.69 BMP2 STAT3 TGFB1
5 positive regulation of gene expression GO:0010628 9.67 BMP2 CRP STAT3 TGFB1
6 Notch signaling pathway GO:0007219 9.66 BMP2 TGFB1
7 response to ethanol GO:0045471 9.65 BGLAP STAT3
8 response to estradiol GO:0032355 9.65 STAT3 TGFB1
9 osteoblast differentiation GO:0001649 9.65 BGLAP BMP2
10 response to organic substance GO:0010033 9.64 STAT3 TGFB1
11 ossification GO:0001503 9.63 BGLAP BMP2
12 cell development GO:0048468 9.63 BMP2 TGFB1
13 aging GO:0007568 9.63 BGLAP STAT3 TGFB1
14 regulation of MAPK cascade GO:0043408 9.62 BMP2 TGFB1
15 SMAD protein signal transduction GO:0060395 9.62 BMP2 TGFB1
16 inner ear development GO:0048839 9.61 BMP2 TGFB1
17 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.6 BMP2 TGFB1
18 negative regulation of cell cycle GO:0045786 9.59 BMP2 TGFB1
19 positive regulation of epithelial to mesenchymal transition GO:0010718 9.58 BMP2 TGFB1
20 bone mineralization GO:0030282 9.58 BGLAP BMP2
21 response to organic cyclic compound GO:0014070 9.58 BGLAP STAT3 TGFB1
22 chondrocyte differentiation GO:0002062 9.57 BMP2 TGFB1
23 epithelial to mesenchymal transition GO:0001837 9.56 BMP2 TGFB1
24 inflammatory response GO:0006954 9.56 BMP2 CRP STAT3 TGFB1
25 acute-phase response GO:0006953 9.55 CRP STAT3
26 positive regulation of bone mineralization GO:0030501 9.52 BMP2 TGFB1
27 response to vitamin D GO:0033280 9.49 BGLAP TGFB1
28 positive regulation of superoxide anion generation GO:0032930 9.48 CRP TGFB1
29 pathway-restricted SMAD protein phosphorylation GO:0060389 9.43 BMP2 TGFB1
30 cellular response to organic cyclic compound GO:0071407 9.33 BMP2 STAT3 TGFB1
31 positive regulation of odontogenesis GO:0042482 9.32 BMP2 TGFB1
32 cellular response to growth factor stimulus GO:0071363 9.13 BGLAP BMP2 TGFB1
33 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.8 BMP2 STAT3 TGFB1

Molecular functions related to Bone Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta receptor binding GO:0005160 8.62 BMP2 TGFB1

Sources for Bone Fracture

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....