Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: BNF002
MIFTS: 55

Bone Fracture

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Drugs
Sources

Aliases & Classifications for Bone Fracture

About this section

MalaCards integrated aliases for Bone Fracture:

Name: Bone Fracture 38 55

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Bone Fracture

About this section
MalaCards based summary : Bone Fracture is related to osteofibrous dysplasia and osteoporosis. An important gene associated with Bone Fracture is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. The drugs Teriparatide and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Adipose, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 A bone fracture (sometimes abbreviated FRX or Fx, Fx, or #) is a medical condition in which there is a... more...

Sources

Related Diseases for Bone Fracture

About this section

Diseases related to Bone Fracture via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 osteofibrous dysplasia 32.1 BGLAP BMP2 TGFB1
2 osteoporosis 29.9 BGLAP BMP2 CRP LRP5 TGFB1
3 spinal muscular atrophy, type i, with congenital bone fractures 12.4
4 spinal muscular atrophy with congenital bone fractures 2 12.3
5 prenatal-onset spinal muscular atrophy with congenital bone fractures 12.0
6 antley-bixler syndrome without genital anomalies or disordered steroidogenesis 11.2
7 antley-bixler syndrome 11.0
8 polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy 11.0
9 hyper-ige recurrent infection syndrome, autosomal dominant 10.9
10 osteogenesis imperfecta, type ii 10.9
11 gnathodiaphyseal dysplasia 10.9
12 marsili syndrome 10.8
13 osteogenesis imperfecta, type i 10.8
14 mucolipidosis iii alpha/beta 10.8
15 multiple pterygium syndrome, lethal type 10.8
16 osteoporosis-pseudoglioma syndrome 10.8
17 pyle disease 10.8
18 spinal muscular atrophy, x-linked 2 10.8
19 osteogenesis imperfecta, type v 10.8
20 cerebroretinal microangiopathy with calcifications and cysts 1 10.8
21 neuropathy, hereditary sensory and autonomic, type vii 10.8
22 bruck syndrome 10.8
23 rickets 10.8
24 tetanus 10.8
25 osteitis fibrosa 10.8
26 cerebrospinal fluid leak 10.8
27 aortic valve disease 1 10.5 BMP2 CRP TGFB1
28 intestinal disease 10.5 CRP STAT3 TLR4
29 glanders 10.5 LRP5 TLR4
30 eosinophilic variant of chromophobe renal cell carcinoma 10.5 CAV1 TGFB1
31 respiratory system disease 10.5 CRP TGFB1 TLR4
32 camurati-engelmann disease 10.4 BGLAP LRP5 TGFB1
33 variola major 10.4 IL2 TLR4
34 bone resorption disease 10.4 BGLAP BMP2 LRP5
35 bone remodeling disease 10.4 BGLAP BMP2 LRP5
36 aortic valve disease 2 10.4 BMP2 CRP MYH7
37 virus associated hemophagocytic syndrome 10.3 IL2 MB
38 periodontitis 10.3 BGLAP CRP TLR4
39 brucellosis 10.3 CRP IL2 TLR4
40 bone inflammation disease 10.3 BGLAP CRP IL2
41 primary bacterial infectious disease 10.2 CRP IL2 TLR4
42 heritable pulmonary arterial hypertension 10.2 CAV1 TGFB1
43 facial paralysis 10.0
44 chagas disease 10.0 IL2 TGFB1 TLR4
45 aging 10.0
46 visceral leishmaniasis 9.9 CRP IL2 TLR4
47 leukocyte disease 9.9 CRP IL2 IL3
48 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.9
49 cerebritis 9.9
50 brain injury 9.8

Graphical network of the top 20 diseases related to Bone Fracture:



Diseases related to Bone Fracture
Sources

Symptoms & Phenotypes for Bone Fracture

About this section

MGI Mouse Phenotypes related to Bone Fracture:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.25 BMP2 CAV1 CRP FGF2 IL2 LRP5
2 cellular MP:0005384 10.14 IL2 LRP5 MB STAT3 TGFB1 TGFBR3
3 hematopoietic system MP:0005397 10.11 LRP5 LTBP1 MB STAT3 TGFB1 TGFBR3
4 immune system MP:0005387 10.02 BMP2 CAV1 CRP IL2 LRP5 LTBP1
5 liver/biliary system MP:0005370 9.86 CAV1 IL2 LRP5 LTBP1 STAT3 TGFB1
6 muscle MP:0005369 9.85 MYH7 PCOLCE STAT3 TGFB1 TGFBR3 TLR4
7 neoplasm MP:0002006 9.43 CAV1 FGF2 IL2 STAT3 TGFB1 TLR4
8 skeleton MP:0005390 9.32 BMP2 CAV1 FGF2 LRP5 LTBP1 PCOLCE
Sources

Drugs & Therapeutics for Bone Fracture

About this section

Drugs for Bone Fracture (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 767)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Teriparatide Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 52232-67-4 16133850
2
Bupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 2180-92-9, 38396-39-3 2474
3
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-02-2 5743
4
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
5
Iron Approved Phase 4,Phase 3,Phase 2,Not Applicable 7439-89-6 23925
6
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2,Not Applicable 1197-18-8 5526
7
Levobupivacaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 27262-47-1 92253
8
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 2078-54-8 4943
9
Ropivacaine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84057-95-4 71273 175805
10
Calcium Carbonate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 471-34-1
11
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Not Applicable 113775-47-6 68602 5311068
12
Thrombin Approved, Investigational Phase 4,Phase 3
13
Morphine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 57-27-2 5288826
14
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-78-2 2244
15
Cilostazol Approved, Investigational Phase 4,Not Applicable 73963-72-1 2754
16
Clopidogrel Approved Phase 4,Not Applicable 120202-66-6, 113665-84-2 60606
17
Cefmetazole Approved, Investigational Phase 4 56796-20-4 42008
18
Celecoxib Approved, Investigational Phase 4,Not Applicable 169590-42-5 2662
19
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
20
Ketorolac Approved Phase 4,Phase 3,Phase 2,Not Applicable 74103-06-3, 66635-83-4 3826
21
Oxycodone Approved, Illicit, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable,Early Phase 1 76-42-6 5284603
22
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
23
Linagliptin Approved Phase 4 668270-12-0 10096344
24
Pioglitazone Approved, Investigational Phase 4,Phase 2 111025-46-8 4829
25
Letrozole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 112809-51-5 3902
26
Zoledronic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 118072-93-8 68740
27
Omeprazole Approved, Investigational, Vet_approved Phase 4,Phase 3 73590-58-6 4594
28
AT-101 Approved, Investigational Phase 4 90141-22-3, 652-67-5 12597
29
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
30
Nitric Oxide Approved Phase 4,Phase 1 10102-43-9 145068 160954
31
Etomidate Approved Phase 4 33125-97-2 36339 667484
32
Hydrocortisone Approved, Vet_approved Phase 4,Not Applicable 50-23-7 5754
33
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Not Applicable 59467-70-8 4192
34
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
35
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 437-38-7 3345
36
Indapamide Approved Phase 4 26807-65-8 3702
37
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
38
Tramadol Approved, Investigational Phase 4,Phase 2,Not Applicable 27203-92-5 33741
39
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Not Applicable 28523-86-6 5206
40
Desflurane Approved Phase 4,Not Applicable 57041-67-5 42113
41
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
42
Ketamine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 6740-88-1 3821
43
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 83-43-2 6741
44
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 50-24-8 5755
45
Dalteparin Approved Phase 4,Phase 3,Phase 2,Not Applicable 9005-49-6
46
Heparin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 9005-49-6 772 46507594
47
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1 15687-27-1 3672
48
Anastrozole Approved, Investigational Phase 4,Phase 3 120511-73-1 2187
49
Acetylcholine Approved Phase 4,Phase 1,Not Applicable 51-84-3 187
50
Cimetidine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 51481-61-9 2756

Interventional clinical trials:

(show top 50) (show all 3392)
# Name Status NCT ID Phase Drugs
1 Treatment of Intertrochanteric Fracture With New Type of Intramedullary Nail Unknown status NCT01437176 Phase 4
2 The Use of Teriparatide as an Adjunctive Therapy for the Treatment of Jones Fractures Unknown status NCT01173081 Phase 4 Teriparatide;Placebo
3 Comparison Study of 3-4-screws-internal Fixation With Multi-screw-system Targon FN for Femoral Neck Fracture Unknown status NCT00829725 Phase 4
4 Obturator and Femoral Nerve Block in Patients With Hip Fracture Unknown status NCT02540837 Phase 4 Bupivacaine;Saline
5 NovaLign Intramedullary Fixation System (IFS) for the Treatment of Humeral Fractures Unknown status NCT00969839 Phase 4
6 Parathyroid Hormone for the Treatment of Humerus Fractures Unknown status NCT01687374 Phase 4 1-84 parathyroid hormone;Placebo
7 Single Dose of Dexamethasone in Femur Fractures Unknown status NCT01550146 Phase 4 Dexamethasone acetate;Placebo
8 Outcome Comparison Between PFNA and InterTAN Unknown status NCT01797237 Phase 4
9 Hematoma Block for Reduction of Distal Radius Fractures Unknown status NCT02129270 Phase 4 Lidocaine HCl 2% .;Lidocaine HCl 1%
10 The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery Unknown status NCT00162617 Phase 4 Red blood cell transfusion
11 Efficacy and Safety of Intravenous Iron Sucrose in Patients With Hip Fracture to Prevent Perioperative Anemia Unknown status NCT01084122 Phase 4 Iron sucrose
12 Comparing Weight Bearing After Intramedullary Fixation Devices for the Proximal Femur Fracture Unknown status NCT01509859 Phase 4
13 Dose Finding Study for Continuous Spinal Anaesthesia Unknown status NCT01680120 Phase 4
14 Tranexamic Acid in Intertrochanteric and Subtrochanteric Femur Fractures Unknown status NCT02580227 Phase 4 Tranexamic Acid
15 A Dose Finding Study for Pain Relief of a Broken Hip Unknown status NCT00926666 Phase 4 Levobupivacaine
16 Study of Nerve Block Anesthesia for Surgery of Hip Fracture in the Elderly Unknown status NCT02104908 Phase 4
17 Analgesic Effects of the Gastrolith, in Osteoporotic Patients Suffering From Recent Skeletal Pain Caused by Vertebral Fractures Unknown status NCT01482858 Phase 4
18 Postoperative Recovery in Elderly Patients Undergoing Hip Hemi-arthroplasty Unknown status NCT01934049 Phase 4 Total Intravenous Anesthesia and Peripheral nerve blocks
19 Hemostasis in Kocher-Langenbeck Approaches for Acetabular Surgery Using a Topical Surgical Hemostat (Vitagel) Unknown status NCT01230931 Phase 4
20 Intrathecal Morphine,Femoral Nerve Block,Periarticular Bupivacaine Infiltration for Pain After Intramedullary Hip Screw Unknown status NCT01219088 Phase 4 Bupivacaine, morphine
21 Monopolar Electrosurgery Versus Ultrasound Scissors in Thoracoscopic Ventral Spondylodesis Unknown status NCT00941213 Phase 4
22 Efficacy of Self-Expanding Nitinol S.M.A.R.T CONTROL Stent Versus Life Stent For The Atherosclerotic Femoro-Popliteal Arterial Disease Unknown status NCT01653600 Phase 4
23 The Effect of Periarticular Multi-Drug Regimen on Pain After Partial Hip Replacement Unknown status NCT01112436 Phase 4 periarticular injection of multidrug regimen;none of medication preoperatively and intraoperatively
24 Clinical Comparison of Efficacy and Safety of Two Teriparatide Formulations: Osteofortil and Forteo Unknown status NCT01945788 Phase 4 Teriparatide (rDNA origin)
25 A One-year Randomized Controlled Trial Evaluating the Impact of Pioglitazone Versus Linagliptin on Bone Turnover Markers Unknown status NCT02429232 Phase 4 Pioglitazone;Linagliptin
26 Evaluation of Predictive Factors Regarding the Effectivity of Aromatase Inhibitor Therapy (PreFace) Unknown status NCT01908556 Phase 4 Letrozole
27 The Effect of Zoledronic Acid to Bone Fusion and Bone Metabolism of Patients With Lumbar Degenerative Disease After Lumbar Interbody Fusion Unknown status NCT01310465 Phase 4 zoledronic acid;sodium chloride
28 Randomized, Double Blind, Placebo Control Trial to Evaluate the Efficacy of Wu-Chu-Yu Tang on Gastroesophageal Reflux Disease (GERD) Unknown status NCT01822106 Phase 4
29 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
30 Effects of Etomidate on Postoperative Circadian Rhythm Changes of Salivary Cortisol in Children Unknown status NCT02013986 Phase 4 etomidate;midazolam;propofol
31 Role of Stress Reduction Protocol on Outcome of Periodontal Therapy Unknown status NCT02487862 Phase 4
32 Bone Turnover in Type 2 Diabetes Patients Unknown status NCT00732121 Phase 4 Sitagliptin;Placebo
33 Manually Versus Digitally Fabricated Removable Partial Dentures Unknown status NCT01191073 Phase 4
34 Determination of Vitamin D Dose to Maintain Sufficiency Amongst Indian and Malay Women in the Tropics Unknown status NCT02389179 Phase 4 Vitamin D3
35 Evaluation of the Efficacy in Decreasing Iron Absorption in Patients With Congenital Dyserythropoietic Anemia Type I by Treatment With LOSEC Unknown status NCT01795794 Phase 4 omeprazole
36 Evaluate the Relationship of Bone Remodeling Markers for Skeletal Complications in Metastatic Breast Cancer Patients Unknown status NCT00912938 Phase 4 zoledronic acid
37 Intranasal Fentanyl for Pain Management Unknown status NCT00882960 Phase 4 intravenous fentanyl;intra-nasal fentanyl
38 Comparison of Efficacy and Safety of Microfracture and Modified Microfracture Unknown status NCT02539030 Phase 4
39 The Hypertension in the Very Elderly Trial (HYVET) Unknown status NCT00122811 Phase 4 Indapamide SR 1.5mg; Perindopril 2-4mg
40 Study Evaluating InductOs in Diaphyseal Tibia Fractures Completed NCT00161616 Phase 4 InductOs
41 Outcomes of Operative Treatment of Unstable Ankle Fracture - Comparison Between Metallic and Biodegradable Implants Completed NCT01431560 Phase 4
42 Treatment of Acetabular Posterior Wall Fracture With Anatomical Locking Plate Completed NCT01437150 Phase 4
43 Evaluation of the Effects of Less Invasive Stabilization System (LISS) Plating Techniques in Distal Femoral Fractures Completed NCT00552331 Phase 4
44 Allomatrix Injectable Putty in Distal Radius Fractures Completed NCT00274378 Phase 4
45 Efficacy of DBM on Fractures of the Shinbone (Tibia) Completed NCT00299052 Phase 4
46 RCT on Ketorolac and Tramadol in Bone Fractures Pain of Child Completed NCT00560443 Phase 4 ketorolac;tramadol
47 Effect of Anesthesia in Fracture Healing Completed NCT02621255 Phase 4 Sevoflurane;Bupivacaine
48 Study Of Tranexamic Acid For The Reduction Of Blood Loss In Patients Undergoing Surgery For Long Bone Fracture Completed NCT00824564 Phase 4 Tranexamic Acid plus standard of care
49 Perioperative Analgesia by Femoral Perineural Catheter for Femoral Neck Fracture - Study KTcol Completed NCT01052974 Phase 4 ropivacaine
50 Evaluation of Surgical Treatment on Pain and Disability for Chronic, Non-healing Rib Fracture Completed NCT00774618 Phase 4

Search NIH Clinical Center for Bone Fracture

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Bone Fracture cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Bone Fracture:
ALLOB
Bone marrow-derived mesenchymal stem cells for treatment of atrophic nonunion fractures
Map3
Ovation
PREOB
Stromal vascular fraction cells for osteoporotic bone fractures
Embryonic/Adult Cultured Cells Related to Bone Fracture:
Bone marrow-derived mesenchymal stem cells PMIDs: 23180104
Bone marrow-derived adherent progenitor cells (MultiStem)
Stromal vascular fraction cells PMIDs: 21605897 16488036
Sources

Genetic Tests for Bone Fracture

About this section
Sources

Anatomical Context for Bone Fracture

About this section

MalaCards organs/tissues related to Bone Fracture:

41
Bone, Prostate, Breast, Kidney, Bone Marrow, Spinal Cord, Testes
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Bone Fracture:
# Tissue Anatomical CompartmentCell Relevance
1 Adipose Subcutaneous White Adipose Mesenchymal Stem Cells Potential therapeutic candidate
2 Adipose Subcutaneous White Adipose Stromal Cells Potential therapeutic candidate
Sources

Publications for Bone Fracture

About this section

Articles related to Bone Fracture:

(show top 50) (show all 718)
# Title Authors Year
1
The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings. ( 29356996 )
2018
2
Mineralized collagen fibril network spatial arrangement influences cortical bone fracture behavior. ( 29137726 )
2018
3
Pain Intensity and Risk of Bone Fracture in Children With Minor Extremity Injuries. ( 29369266 )
2018
4
Hypophosphatemic Osteomalacia with Multiple Bone Fractures: ADV-Induced Fanconi's Syndrome. ( 29399572 )
2018
5
Temporary inhibition of the plasminogen activator inhibits periosteal chondrogenesis and promotes periosteal osteogenesis during appendicular bone fracture healing. ( 29680264 )
2018
6
New Insights in Understanding and Treating Bone Fracture Pain. ( 29948820 )
2018
7
Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice. ( 29765320 )
2018
8
Association Between Inhaled Corticosteroid Use and Bone Fracture in Children With Asthma. ( 29131874 )
2018
9
Calcium and vitamin D in bone fracture healing and post-traumatic bone turnover. ( 29931664 )
2018
10
Estrogen receptor I+- (ERI+), but not ERI^-signaling, is crucially involved in mechanostimulation of bone fracture healing by whole-body vibration. ( 29367057 )
2018
11
Can quantitative computed tomography detect bone morphological changes associated with catastrophic proximal sesamoid bone fracture in Thoroughbred racehorses? ( 29758110 )
2018
12
A CONCOMITANT BONE FRACTURE DELAYS COGNITIVE RECOVERY FROM TRAUMATIC BRAIN INJURY. ( 29787539 )
2018
13
Pronounced femur malunion after pathological bone fracture due to a simple bone cyst in the shaft of the femur, treated using Ilizarov fixation: a case report. ( 29925426 )
2018
14
Anabolic Strategies to Augment Bone Fracture Healing. ( 29725836 )
2018
15
Bariatric surgery increases risk of bone fracture. ( 29713829 )
2018
16
Effect of ultrasound on bone fracture healing: A computational bioregulatory model. ( 29975857 )
2018
17
Pseudo-malignant osteolysis of the pelvis: Unusual pattern of pubic bone fracture. ( 29709697 )
2018
18
Dietary fat, saturated fatty acid, and monounsaturated fatty acid intakes and risk of bone fracture: a systematic review and meta-analysis of observational studies. ( 29947872 )
2018
19
Distinct Effects of IL-6 Classic and Trans-Signaling in Bone Fracture Healing. ( 29146294 )
2018
20
Discovery of a novel 2-(1H-pyrazolo[3,4-b]pyridin-1-yl)thiazole derivative as an EP<sub>1</sub> receptor antagonist and in vivo studies in a bone fracture model. ( 29934246 )
2018
21
Optimal administration frequency and dose of teriparatide for acceleration of biomechanical healing of long-bone fracture in a mouse model. ( 29721806 )
2018
22
The Impact of Type 2 Diabetes on Bone Fracture Healing. ( 29416527 )
2018
23
Usefulness of indirect open reduction via a transconjunctival approach for the treatment of nasal bone fracture associated with orbital blowout fracture. ( 29788695 )
2018
24
Assessment of cortical bone fracture resistance curves by fusing artificial neural networks and linear regression. ( 29383945 )
2018
25
Accuracy in Screw Selection in a Cadaveric, Small-Bone Fracture Model. ( 29801935 )
2018
26
Application of resampling techniques to improve the quality of survival analysis risk curves for human frontal bone fracture. ( 29753560 )
2018
27
Hypoglossal-facial nerve &amp;quot;side&amp;quot;-to-side neurorrhaphy for facial paralysis resulting from closed temporal bone fractures. ( 29889081 )
2018
28
Otopathologic Changes in the Cochlea following Head Injury without Temporal Bone Fracture. ( 29890895 )
2018
29
Impact of Bone Fracture on Ischemic Stroke Recovery. ( 29786644 )
2018
30
Effects of obesity on the healing of bone fracture in mice. ( 29880016 )
2018
31
A review of computational models of bone fracture healing. ( 28785849 )
2017
32
Osthole Promotes Bone Fracture Healing through Activation of BMP Signaling in Chondrocytes. ( 28924381 )
2017
33
Bone fracture nonunion rate decreases with increasing age: A prospective inception cohort study. ( 27836732 )
2017
34
Bone fracture risk in patients with rheumatoid arthritis: A meta-analysis. ( 28885321 )
2017
35
Reliability of temporal bone high-resolution CT in patients with facial paralysis in temporal bone fracture. ( 29258690 )
2017
36
Controlled and sustained delivery of siRNA/NPs from hydrogels expedites bone fracture healing. ( 28601703 )
2017
37
Non-union bone fracture: a quicker fix. ( 29069072 )
2017
38
The effects of dipeptidyl peptidase-4 inhibitors on bone fracture among patients with type 2 diabetes mellitus: A network meta-analysis of randomized controlled trials. ( 29206832 )
2017
39
An Algorithmic Approach Using Ultrasonography in the Diagnosis of Pediatric Nasal Bone Fracture. ( 27906845 )
2017
40
Delayed Expression of Circulating TGF-I^1 and BMP-2 Levels in Human Nonunion Long Bone Fracture Healing. ( 28331138 )
2017
41
Pathological bone fractures in a patient with parathyroid carcinoma - A Case Report. ( 29256556 )
2017
42
Occurrence of Clinical Bone Fracture Following a Prolonged Stay in Intensive Care Unit: A Retrospective Controlled Study. ( 28695239 )
2017
43
A Rare Case of Infantile Myofibromatosis Presenting to the Emergency Department as Undiagnosed Long Bone Fractures. ( 29095782 )
2017
44
Study of fall risk-increasing drugs in elderly patients before and after a bone fracture. ( 28916557 )
2017
45
Epidemiology of Bone Fracture in Female Trauma Patients Based on Risks of Osteoporosis Assessed using the Osteoporosis Self-Assessment Tool for Asians Score. ( 29137199 )
2017
46
The effect of light-emitting diode (590/830A nm)-based low-level laser therapy on posttraumatic edema of facial bone fracture patients. ( 28986000 )
2017
47
Actual reason for bone fractures in the case of a patient followed-up with the osteogenesis imperfecta: Gaucher's Disease. ( 29354164 )
2017
48
The role of impairment of mesenchymal stem cell function in osteoporotic bone fracture healing. ( 28677081 )
2017
49
In vivo study of microarc oxidation coated biodegradable magnesium plate to heal bone fracture defect of 3mm width. ( 28688364 )
2017
50
The Algorithm-Oriented Management of Nasal Bone Fracture according to Stranc's Classification System. ( 28913315 )
2017
Sources

Variations for Bone Fracture

About this section
Sources

Expression for Bone Fracture

About this section
Search GEO for disease gene expression data for Bone Fracture.
Sources

Pathways for Bone Fracture

About this section

Pathways related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 36)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 64
Show member pathways
 13.68 BMP2 FGF2 IL2 IL3 LRP5 LTBP1
2
GPCR Pathway 64
Show member pathways
 13.66 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
3
Activation of cAMP-Dependent PKA 64
Show member pathways
 13.46 BMP2 CRP FGF2 IL2 IL3 LTBP1
4
TGF-Beta Pathway 64
Show member pathways
 13.38 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
5
Akt Signaling 64
Show member pathways
 13.26 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
6
CREB Pathway 64
Show member pathways
 13.22 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
7
Nanog in Mammalian ESC Pluripotency 64
Show member pathways
 13.16 BMP2 CAV1 FGF2 IL2 IL3 LTBP1
8
PAK Pathway 64
Show member pathways
 13.02 BMP2 FGF2 IL2 IL3 LTBP1 MYH2
9
Phospholipase-C Pathway 64
Show member pathways
 12.81 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
10
p70S6K Signaling 64
Show member pathways
 12.69 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
11
Degradation of the extracellular matrix 66
Show member pathways
 12.67 BMP2 FGF2 LTBP1 PCOLCE TGFB1
12
Pathways in cancer 37
12.63 BMP2 FGF2 IL2 IL3 LRP5 STAT3
13
Human Embryonic Stem Cell Pluripotency 64
Show member pathways
 12.41 BMP2 FGF2 MYH7 TGFB1
14
Th17 cell differentiation 37
Show member pathways
 12.38 IL2 STAT3 TGFB1 TLR4
15
Th1 Differentiation Pathway 65
Show member pathways
 12.19 IL2 STAT3 TGFB1 TLR4
16
Proteoglycans in cancer 37
12.18 CAV1 FGF2 STAT3 TGFB1 TLR4
17
NF-KappaB Family Pathway 64
Show member pathways
 12.18 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
18
Colorectal Cancer Metastasis 64
12.12 LRP5 STAT3 TGFB1 TLR4
19
MicroRNAs in cardiomyocyte hypertrophy 1
Show member pathways
 12.09 FGF2 LRP5 STAT3 TGFB1
20
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.99 FGF2 IL3 STAT3 TGFB1
21
Senescence and Autophagy in Cancer 1
11.87 BMP2 IL3 TGFB1
22
Corticotropin-releasing hormone signaling pathway 1
11.81 IL2 TGFB1 TLR4
23
Cytokine production by Th17 cells in CF (Mouse model) 22
Show member pathways
 11.8 STAT3 TGFB1 TLR4
24
Angiogenesis (CST) 4
11.78 FGF2 TGFB1 TGFBR3
25
TGF-beta signaling pathway (KEGG) 37
11.74 BMP2 LTBP1 TGFB1
26
Primary Focal Segmental Glomerulosclerosis FSGS 1
11.68 LRP5 TGFB1 TLR4
27
Elastic fibre formation 66
Show member pathways
 11.67 BMP2 LTBP1 TGFB1
28
TGF-beta receptor signaling (Pathway Interaction Database) 1
11.49 CAV1 TGFB1 TGFBR3
29
Cell adhesion_Plasmin signaling 22
11.47 FGF2 TGFB1 TGFBR3
30
TGF-beta Receptor Signaling (WikiPathways) 1
11.47 LTBP1 STAT3 TGFB1 TGFBR3
31
Differentiation Pathway 1
11.45 FGF2 IL3 TGFB1
32
Interleukin-11 Signaling Pathway 1
11.4 BGLAP STAT3 TGFB1
33
Immune response IFN gamma signaling pathway 22
Show member pathways
 11.24 BMP2 FGF2 IL2 IL3 LTBP1 NUDT6
34
Cytokines and Inflammatory Response 1
11.2 IL2 IL3 TGFB1
35
IL12 signaling mediated by STAT4 1
11.15 IL2 STAT3 TGFB1
Sources

GO Terms for Bone Fracture

About this section

Cellular components related to Bone Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 BGLAP BMP2 CRP CRTAC1 FGF2 IL2
2 extracellular space GO:0005615 9.32 BGLAP BMP2 CRP FGF2 IL2 IL3

Biological processes related to Bone Fracture according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.92 FGF2 IL2 IL3 TGFB1
2 inflammatory response GO:0006954 9.92 BMP2 CRP STAT3 TGFB1 TLR4
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.88 BMP2 FGF2 TGFB1 TLR4
4 positive regulation of cell proliferation GO:0008284 9.88 FGF2 IL2 IL3 LRP5 STAT3 TGFB1
5 cytokine-mediated signaling pathway GO:0019221 9.83 FGF2 IL2 IL3 STAT3 TGFB1
6 BMP signaling pathway GO:0030509 9.8 BMP2 TGFB1 TGFBR3
7 cellular response to organic cyclic compound GO:0071407 9.74 BMP2 STAT3 TGFB1
8 negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 9.73 CAV1 TGFB1 TGFBR3
9 regulation of signaling receptor activity GO:0010469 9.73 BMP2 FGF2 IL2 IL3 NUDT6 TGFB1
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.72 IL2 IL3 STAT3
11 somatic stem cell population maintenance GO:0035019 9.71 FGF2 LRP5 STAT3
12 cellular response to growth factor stimulus GO:0071363 9.69 BGLAP BMP2 TGFB1
13 regulation of regulatory T cell differentiation GO:0045589 9.64 IL2 TGFB1
14 hyaluronan catabolic process GO:0030214 9.64 FGF2 TGFB1
15 positive regulation of superoxide anion generation GO:0032930 9.63 CRP TGFB1
16 positive regulation of peptidase activity GO:0010952 9.63 CAV1 PCOLCE
17 epithelial to mesenchymal transition GO:0001837 9.63 BMP2 TGFB1 TGFBR3
18 positive regulation of gene expression GO:0010628 9.63 BMP2 CAV1 CRP STAT3 TGFB1 TLR4
19 cardiac epithelial to mesenchymal transition GO:0060317 9.61 BMP2 TGFBR3
20 positive regulation of interleukin-17 production GO:0032740 9.61 IL2 TGFB1
21 positive regulation of osteoblast proliferation GO:0033690 9.6 BMP2 LRP5
22 negative regulation of interleukin-17 production GO:0032700 9.59 TGFB1 TLR4
23 positive regulation of regulatory T cell differentiation GO:0045591 9.58 IL2 TGFB1
24 ventricular cardiac muscle tissue morphogenesis GO:0055010 9.54 MYH7 TGFB1 TGFBR3
25 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.5 BMP2 STAT3 TGFB1
26 positive regulation of odontogenesis GO:0042482 9.48 BMP2 TGFB1
27 response to hypoxia GO:0001666 9.35 BMP2 CAV1 MB TGFB1 TGFBR3
28 pathway-restricted SMAD protein phosphorylation GO:0060389 8.8 BMP2 TGFB1 TGFBR3
29 positive regulation of transcription, DNA-templated GO:0045893 10.04 BMP2 FGF2 LRP5 STAT3 TGFB1
30 positive regulation of transcription by RNA polymerase II GO:0045944 10.04 BMP2 FGF2 IL2 LRP5 STAT3 TGFB1

Molecular functions related to Bone Fracture according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 BMP receptor binding GO:0070700 9.4 BMP2 TGFB1
2 peptidase activator activity GO:0016504 9.37 CAV1 PCOLCE
3 cytokine activity GO:0005125 9.35 BMP2 FGF2 IL2 IL3