MCID: BNG005
MIFTS: 32

Bone Giant Cell Sarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Giant Cell Sarcoma

MalaCards integrated aliases for Bone Giant Cell Sarcoma:

Name: Bone Giant Cell Sarcoma 12 15
Giant Cell Tumor of Bone, Malignant 12
Giant Cell Sarcoma of the Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4719
NCIt 50 C4304
SNOMED-CT 67 10069009
UMLS 70 C0334552

Summaries for Bone Giant Cell Sarcoma

Disease Ontology : 12 A malignant giant cell tumor that is composed of multinucleated giant cells.

MalaCards based summary : Bone Giant Cell Sarcoma, also known as giant cell tumor of bone, malignant, is related to malignant giant cell tumor and bone giant cell tumor. An important gene associated with Bone Giant Cell Sarcoma is H3-3B (H3.3 Histone B), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and PEDF Induced Signaling. Affiliated tissues include bone, lung and brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Bone Giant Cell Sarcoma

Diseases related to Bone Giant Cell Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 malignant giant cell tumor 30.6 H3-3B H3-3A
2 bone giant cell tumor 29.8 TNFSF11 H3-3B H3-3A CSF1
3 benign giant cell tumor 29.8 TNFSF11 H3-3B H3-3A CSF1
4 adult brain stem glioma 10.3 H3-3B H3-3A
5 telangiectatic osteogenic sarcoma 10.3 H3-3B H3-3A
6 spinal cord astrocytoma 10.3 H3-3B H3-3A
7 adult oligodendroglioma 10.3 H3-3B H3-3A
8 childhood oligodendroglioma 10.3 H3-3B H3-3A
9 childhood brain stem glioma 10.3 H3-3B H3-3A
10 childhood pilocytic astrocytoma 10.3 H3-3B H3-3A
11 juvenile pilocytic astrocytoma 10.3 H3-3B H3-3A
12 clear cell chondrosarcoma 10.3 H3-3B H3-3A
13 chondroblastic osteosarcoma 10.2 H3-3B H3-3A
14 colon leiomyoma 10.2 H3-3B H3-3A
15 spinal cord glioma 10.2 H3-3B H3-3A
16 mature teratoma 10.2 TP53 KRAS
17 spinal cancer 10.2 H3-3B H3-3A
18 brain stem cancer 10.2 H3-3B H3-3A
19 liver angiosarcoma 10.2 TP53 KRAS
20 endometrioid ovary carcinoma 10.2 TP53 KRAS
21 spitz nevus 10.2 TP53 HRAS
22 alpha thalassemia-x-linked intellectual disability syndrome 10.2 H3-3B H3-3A
23 hepatic flexure cancer 10.2 KRAS HRAS
24 high grade ependymoma 10.2 TP53 H3-3A
25 trachea carcinoma in situ 10.2 KRAS HRAS
26 squamous cell papilloma 10.2 TP53 HRAS
27 signet ring basal cell carcinoma 10.2 KRAS HRAS
28 cobblestone retinal degeneration 10.2 KRAS HRAS
29 immature teratoma of ovary 10.2 KRAS HRAS
30 keratocystic odontogenic tumor 10.2 TP53 TNFSF11
31 descending colon cancer 10.2 KRAS HRAS
32 ampulla of vater benign neoplasm 10.2 KRAS HRAS
33 adult malignant schwannoma 10.1 TP53 HRAS
34 transverse colon cancer 10.1 KRAS HRAS
35 periampullary adenoma 10.1 KRAS HRAS
36 acneiform dermatitis 10.1 KRAS HRAS
37 appendiceal neoplasm 10.1 KRAS HRAS
38 gallbladder benign neoplasm 10.1 KRAS HRAS
39 adenosquamous lung carcinoma 10.1 KRAS HRAS
40 appendix adenocarcinoma 10.1 KRAS HRAS
41 mucinous lung adenocarcinoma 10.1 KRAS HRAS
42 wolffian duct adenocarcinoma 10.1 KRAS HRAS
43 endometrial serous adenocarcinoma 10.1 TP53 KRAS
44 noonan syndrome-like disorder with loose anagen hair 1 10.1 KRAS HRAS
45 noonan syndrome-like disorder with loose anagen hair 10.1 KRAS HRAS
46 myh-associated polyposis 10.1 KRAS HRAS
47 ascending colon cancer 10.1 KRAS HRAS
48 ovarian mucinous neoplasm 10.1 KRAS HRAS
49 pancreatic acinar cell adenocarcinoma 10.1 KRAS HRAS
50 paronychia 10.1 KRAS HRAS

Graphical network of the top 20 diseases related to Bone Giant Cell Sarcoma:



Diseases related to Bone Giant Cell Sarcoma

Symptoms & Phenotypes for Bone Giant Cell Sarcoma

GenomeRNAi Phenotypes related to Bone Giant Cell Sarcoma according to GeneCards Suite gene sharing:

26 (show all 27)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.75 KRAS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.75 KRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.75 CSF1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.75 KRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-165 9.75 KRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.75 KRAS
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.75 KRAS
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.75 CSF1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-183 9.75 HRAS
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-193 9.75 KRAS
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-196 9.75 KRAS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.75 KRAS
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.75 KRAS
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.75 KRAS
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.75 KRAS
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-43 9.75 HRAS
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-47 9.75 CSF1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 9.75 KRAS
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 9.75 KRAS
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.75 KRAS
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.75 KRAS
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.75 HRAS
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.75 CSF1
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-90 9.75 CSF1
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.75 CSF1
26 Decreased shRNA abundance (Z-score < -2) GR00366-A-93 9.75 KRAS
27 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.75 HRAS

MGI Mouse Phenotypes related to Bone Giant Cell Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 CD163 CSF1 FLT4 H3-3B HRAS KRAS
2 craniofacial MP:0005382 9.8 CSF1 HRAS KRAS TNFSF11 TP53
3 integument MP:0010771 9.8 CSF1 FLT4 HRAS KRAS TNFSF11 TP53
4 muscle MP:0005369 9.8 CD163 CSF1 FLT4 HRAS KRAS TNFSF11
5 no phenotypic analysis MP:0003012 9.63 CSF1 FLT4 HRAS KRAS TNFSF11 TP53
6 normal MP:0002873 9.43 FLT4 H3-3B HRAS KRAS TNFSF11 TP53
7 respiratory system MP:0005388 9.1 CD163 CSF1 HRAS KRAS TNFSF11 TP53

Drugs & Therapeutics for Bone Giant Cell Sarcoma

Search Clinical Trials , NIH Clinical Center for Bone Giant Cell Sarcoma

Genetic Tests for Bone Giant Cell Sarcoma

Anatomical Context for Bone Giant Cell Sarcoma

MalaCards organs/tissues related to Bone Giant Cell Sarcoma:

40
Bone, Lung, Brain, Colon, Ovary, Thyroid, Appendix

Publications for Bone Giant Cell Sarcoma

Articles related to Bone Giant Cell Sarcoma:

# Title Authors PMID Year
1
Malignancy in Giant Cell Tumor of Bone: A Review of the Literature. 61
30935298 2019
2
Factor XIIIa-immunoreactivity in tumors of the central nervous system. 61
9561329 1998
3
Malignant giant cell tumor of bone: malignant transformation of a benign giant cell tumor treated by surgery. 61
2175663 1990

Variations for Bone Giant Cell Sarcoma

Expression for Bone Giant Cell Sarcoma

Search GEO for disease gene expression data for Bone Giant Cell Sarcoma.

Pathways for Bone Giant Cell Sarcoma

Pathways related to Bone Giant Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 50)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.66 TP53 KRAS HRAS H3-3B H3-3A FLT4
2
Show member pathways
13.48 TP53 TNFSF11 KRAS HRAS FLT4 CSF1
3
Show member pathways
13.28 TP53 KRAS HRAS H3-3B H3-3A FLT4
4
Show member pathways
13.18 TP53 TNFSF11 KRAS HRAS CSF1
5
Show member pathways
13.13 TP53 KRAS HRAS H3-3B H3-3A
6
Show member pathways
13.11 TNFSF11 KRAS HRAS FLT4 CSF1
7
Show member pathways
13.1 TP53 TNFSF11 KRAS HRAS FLT4 CSF1
8
Show member pathways
13.03 TP53 TNFSF11 KRAS HRAS H3-3B H3-3A
9 12.67 TP53 KRAS HRAS FLT4
10
Show member pathways
12.64 TP53 KRAS HRAS FLT4 CSF1
11
Show member pathways
12.55 KRAS HRAS FLT4 CSF1
12
Show member pathways
12.44 TNFSF11 KRAS HRAS CSF1
13 12.32 TP53 KRAS HRAS FLT4 CSF1
14
Show member pathways
12.28 TP53 KRAS HRAS FLT4
15 12.27 TP53 H3-3B H3-3A
16
Show member pathways
12.22 TP53 H3-3B H3-3A
17
Show member pathways
12.22 TP53 KRAS HRAS
18
Show member pathways
12.22 TP53 TNFSF11 KRAS HRAS FLT4
19 12.2 TP53 KRAS HRAS
20 12.17 TP53 KRAS HRAS
21 12.16 TP53 KRAS HRAS
22
Show member pathways
12.16 TP53 KRAS HRAS
23 12.14 TP53 H3-3B H3-3A
24
Show member pathways
12.09 TP53 KRAS HRAS FLT4
25
Show member pathways
12.02 TP53 KRAS HRAS
26
Show member pathways
12.02 TP53 KRAS HRAS FLT4
27 12 TP53 H3-3B H3-3A
28 12 TP53 KRAS HRAS
29
Show member pathways
11.98 TP53 KRAS HRAS
30
Show member pathways
11.97 TP53 KRAS HRAS
31 11.85 TP53 KRAS HRAS
32 11.84 TP53 KRAS HRAS
33 11.81 TP53 KRAS HRAS
34 11.77 TP53 KRAS HRAS
35
Show member pathways
11.62 KRAS HRAS FLT4
36 11.53 TP53 KRAS HRAS
37 11.48 TP53 KRAS HRAS
38 11.44 TP53 KRAS HRAS
39 11.22 H3-3B H3-3A
40 11.22 KRAS HRAS
41 11.17 KRAS HRAS
42 11.17 KRAS HRAS
43
Show member pathways
11.15 KRAS HRAS
44 11.13 KRAS HRAS FLT4
45
Show member pathways
11.13 TP53 KRAS HRAS H3-3B H3-3A
46 11.03 KRAS HRAS
47 11 KRAS HRAS
48 10.96 KRAS HRAS
50 10.71 KRAS HRAS

GO Terms for Bone Giant Cell Sarcoma

Cellular components related to Bone Giant Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 TNFSF11 H3-3B H3-3A FLT4 CSF1 CD163
2 Barr body GO:0001740 8.62 H3-3B H3-3A

Biological processes related to Bone Giant Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.85 KRAS HRAS FLT4 CSF1
2 cellular protein metabolic process GO:0044267 9.8 H3-3B H3-3A CSF1
3 positive regulation of protein phosphorylation GO:0001934 9.77 KRAS HRAS FLT4
4 cytokine-mediated signaling pathway GO:0019221 9.76 TP53 TNFSF11 KRAS CSF1
5 positive regulation of JNK cascade GO:0046330 9.67 TNFSF11 HRAS FLT4
6 multicellular organism growth GO:0035264 9.65 TP53 H3-3B H3-3A
7 chromatin silencing at rDNA GO:0000183 9.64 H3-3B H3-3A
8 positive regulation of Ras protein signal transduction GO:0046579 9.63 HRAS CSF1
9 osteoclast differentiation GO:0030316 9.63 TNFSF11 CSF1
10 intrinsic apoptotic signaling pathway GO:0097193 9.62 TP53 HRAS
11 cellular response to gamma radiation GO:0071480 9.61 TP53 HRAS
12 nucleus organization GO:0006997 9.61 H3-3B H3-3A
13 Ras protein signal transduction GO:0007265 9.61 TP53 KRAS HRAS
14 telomere organization GO:0032200 9.6 H3-3B H3-3A
15 homeostasis of number of cells within a tissue GO:0048873 9.58 KRAS CSF1
16 cell aging GO:0007569 9.58 TP53 HRAS
17 positive regulation of MAP kinase activity GO:0043406 9.58 TNFSF11 KRAS HRAS
18 DNA replication-independent nucleosome assembly GO:0006336 9.57 H3-3B H3-3A
19 positive regulation of osteoclast differentiation GO:0045672 9.56 TNFSF11 CSF1
20 positive regulation of gene expression GO:0010628 9.55 TP53 TNFSF11 KRAS HRAS CSF1
21 regulation of long-term neuronal synaptic plasticity GO:0048169 9.54 KRAS HRAS
22 muscle cell differentiation GO:0042692 9.52 H3-3B H3-3A
23 response to isolation stress GO:0035900 9.51 KRAS HRAS
24 pericentric heterochromatin assembly GO:0031508 9.37 H3-3B H3-3A
25 osteoclast proliferation GO:0002158 9.32 TNFSF11 CSF1
26 regulation of centromere complex assembly GO:0090230 9.26 H3-3B H3-3A
27 negative regulation of chromosome condensation GO:1902340 8.96 H3-3B H3-3A
28 telomeric heterochromatin assembly GO:0031509 8.62 H3-3B H3-3A

Molecular functions related to Bone Giant Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.62 H3-3B H3-3A

Sources for Bone Giant Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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