MCID: BNG005
MIFTS: 25

Bone Giant Cell Sarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Giant Cell Sarcoma

MalaCards integrated aliases for Bone Giant Cell Sarcoma:

Name: Bone Giant Cell Sarcoma 12 15
Giant Cell Tumor of Bone, Malignant 12
Giant Cell Sarcoma of the Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4719
NCIt 51 C4304
SNOMED-CT 69 10069009
UMLS 74 C0334552

Summaries for Bone Giant Cell Sarcoma

Disease Ontology : 12 A malignant giant cell tumor that is composed_of multinucleated giant cells.

MalaCards based summary : Bone Giant Cell Sarcoma, also known as giant cell tumor of bone, malignant, is related to malignant giant cell tumor and giant cell tumor. An important gene associated with Bone Giant Cell Sarcoma is H3F3A (H3 Histone Family Member 3A), and among its related pathways/superpathways are TGF-Beta Pathway and Cell Cycle, Mitotic. Affiliated tissues include bone.

Related Diseases for Bone Giant Cell Sarcoma

Graphical network of the top 20 diseases related to Bone Giant Cell Sarcoma:



Diseases related to Bone Giant Cell Sarcoma

Symptoms & Phenotypes for Bone Giant Cell Sarcoma

Drugs & Therapeutics for Bone Giant Cell Sarcoma

Search Clinical Trials , NIH Clinical Center for Bone Giant Cell Sarcoma

Genetic Tests for Bone Giant Cell Sarcoma

Anatomical Context for Bone Giant Cell Sarcoma

MalaCards organs/tissues related to Bone Giant Cell Sarcoma:

42
Bone

Publications for Bone Giant Cell Sarcoma

Articles related to Bone Giant Cell Sarcoma:

# Title Authors Year
1
Malignant giant cell tumor of bone: malignant transformation of a benign giant cell tumor treated by surgery. ( 2175663 )
1990

Variations for Bone Giant Cell Sarcoma

Expression for Bone Giant Cell Sarcoma

Search GEO for disease gene expression data for Bone Giant Cell Sarcoma.

Pathways for Bone Giant Cell Sarcoma

Pathways related to Bone Giant Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 H3F3A H3F3B TP53
2
Show member pathways
12.83 H3F3A H3F3B TP53
3
Show member pathways
12.71 H3F3A H3F3B TP53
4
Show member pathways
12.53 H3F3A H3F3B TP53
5
Show member pathways
12 H3F3A H3F3B
6
Show member pathways
11.85 H3F3A H3F3B TP53
7
Show member pathways
11.82 H3F3A H3F3B
8
Show member pathways
11.71 H3F3A H3F3B
9 11.7 H3F3A H3F3B TP53
10
Show member pathways
11.59 H3F3A H3F3B
11 11.53 H3F3A H3F3B TP53
12
Show member pathways
11.23 H3F3A H3F3B TP53
13 10.89 H3F3A H3F3B
14 10.21 H3F3A H3F3B TP53

GO Terms for Bone Giant Cell Sarcoma

Cellular components related to Bone Giant Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.33 H3F3A H3F3B TP53
2 nuclear chromosome, telomeric region GO:0000784 9.32 H3F3A H3F3B
3 nucleosome GO:0000786 9.26 H3F3A H3F3B
4 nuclear chromosome GO:0000228 8.96 H3F3A H3F3B
5 nuclear nucleosome GO:0000788 8.62 H3F3A H3F3B

Biological processes related to Bone Giant Cell Sarcoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.49 H3F3A H3F3B
2 blood coagulation GO:0007596 9.48 H3F3A H3F3B
3 nucleosome assembly GO:0006334 9.46 H3F3A H3F3B
4 positive regulation of cell growth GO:0030307 9.43 H3F3A H3F3B
5 regulation of megakaryocyte differentiation GO:0045652 9.4 H3F3A H3F3B
6 regulation of gene silencing by miRNA GO:0060964 9.37 H3F3A H3F3B
7 negative regulation of gene expression, epigenetic GO:0045814 9.32 H3F3A H3F3B
8 chromatin silencing at rDNA GO:0000183 9.26 H3F3A H3F3B
9 telomere organization GO:0032200 9.16 H3F3A H3F3B
10 cell proliferation GO:0008283 8.65 TP53
11 DNA replication-independent nucleosome assembly GO:0006336 8.62 H3F3A H3F3B

Molecular functions related to Bone Giant Cell Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein heterodimerization activity GO:0046982 9.33 H3F3A H3F3B TP53
2 nucleosomal DNA binding GO:0031492 9.26 H3F3A H3F3B
3 RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 8.96 H3F3A H3F3B
4 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 8.8 H3F3A H3F3B TP53

Sources for Bone Giant Cell Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....