MCID: BNG036
MIFTS: 51

Bone Giant Cell Tumor

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Bone Giant Cell Tumor

MalaCards integrated aliases for Bone Giant Cell Tumor:

Name: Bone Giant Cell Tumor 12 15 17
Giant Cell Tumor of Bone 12 54 60 38 45 74
Osteoclastoma 12 54 60 56
Gct of Bone 54 60
Giant Cell Neoplasm of Bone 12
Giant Cell Myeloma 12

Classifications:

Orphanet: 60  
Rare bone diseases


External Ids:

Disease Ontology 12 DOID:4305
KEGG 38 H01470
MeSH 45 D018212
NCIt 51 C121932
SNOMED-CT 69 57500000
ICD10 via Orphanet 35 D48.0
UMLS via Orphanet 75 C0206638
Orphanet 60 ORPHA363976
UMLS 74 C0206638

Summaries for Bone Giant Cell Tumor

Disease Ontology : 12 A giant cell tumor and bone cancer and bone tissue neoplasm that results in the presence of multinucleated giant cells (osteoclast-like cell).

MalaCards based summary : Bone Giant Cell Tumor, also known as giant cell tumor of bone, is related to malignant giant cell tumor and giant cell tumor, and has symptoms including pain An important gene associated with Bone Giant Cell Tumor is ACP5 (Acid Phosphatase 5, Tartrate Resistant), and among its related pathways/superpathways are Degradation of the extracellular matrix and RANK Signaling in Osteoclasts. The drugs Denosumab and Bone Density Conservation Agents have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and lung, and related phenotypes are immune system and craniofacial

Wikipedia : 77 Giant-cell tumor of the bone, (GCTOB) also called osteoclastoma, is a relatively uncommon tumor of the... more...

Related Diseases for Bone Giant Cell Tumor

Diseases related to Bone Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 malignant giant cell tumor 30.9 ACP5 H3F3A
2 giant cell tumor 30.1 CALCA CTSK H3F3A SERPINA3 TNFSF11
3 aneurysmal bone cysts 30.0 CALCA TNFSF11
4 bone inflammation disease 29.9 ACP5 CTSK TNFSF11
5 villonodular synovitis 29.7 ACP5 TNFSF11
6 chondroblastoma 29.7 H3F3A TNFSF11
7 bone resorption disease 29.6 ACP5 CALCA CTSK SPP1 TNFSF11
8 pigmented villonodular synovitis 29.5 ACP5 CALCR TNFSF11
9 bone disease 29.4 ACP5 CALCA CTSK SPP1 TNFSF11
10 bone giant cell sarcoma 11.3
11 paget disease of bone 6 11.2
12 tendinitis 10.3 ACP5 SPP1
13 giant cell reparative granuloma 10.2 CALCA CALCR
14 paget's disease of bone 10.2
15 hypophosphatasia, adult 10.2 CALCA SPP1
16 sarcoma 10.2
17 secondary hyperparathyroidism of renal origin 10.2 ACP5 CALCA
18 hypercementosis 10.2 ACP5 CTSK SPP1
19 calcific tendinitis 10.1 CTSK SPP1
20 osteogenic sarcoma 10.1
21 paget disease of bone 3 10.1
22 epulis 10.1
23 chondrosarcoma 10.1
24 degos 'en cocarde' erythrokeratoderma 10.1
25 telangiectatic osteogenic sarcoma 10.0 H3F3A ITGAV
26 multicentric carpotarsal osteolysis syndrome 10.0 CTSK TNFSF11
27 paget disease of bone 5, juvenile-onset 9.9 CALCA TNFSF11
28 periapical periodontitis 9.9 ACP5 TNFSF11
29 cherubism 9.9
30 leukemia 9.9
31 transitional cell carcinoma 9.9
32 hairy cell leukemia 9.9
33 adenocarcinoma 9.9
34 astrocytoma 9.9
35 grade iii astrocytoma 9.9
36 papillary transitional carcinoma 9.9
37 enchondroma 9.9
38 ischemic bone disease 9.9 ACP5 TNFSF11
39 tooth resorption 9.9 ACP5 CTSK TNFSF11
40 osteopetrosis, autosomal dominant 2 9.8 ACP5 CTSK TNFSF11
41 retinitis pigmentosa 42 9.8 CTSB ITGAV
42 osteomyelitis 9.8 ACP5 CTSK TNFSF11
43 renal cell carcinoma, nonpapillary 9.8
44 pulmonary arteriovenous fistulas 9.8
45 aging 9.8
46 burns 9.8
47 osteonecrosis 9.8
48 angiosarcoma 9.8
49 paraganglioma 9.8
50 osteomalacia 9.8

Graphical network of the top 20 diseases related to Bone Giant Cell Tumor:



Diseases related to Bone Giant Cell Tumor

Symptoms & Phenotypes for Bone Giant Cell Tumor

UMLS symptoms related to Bone Giant Cell Tumor:


pain

MGI Mouse Phenotypes related to Bone Giant Cell Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.86 CALCR CTSB CTSK ITGAV SPP1 THBS1
2 craniofacial MP:0005382 9.72 CTSK ITGAV SPP1 THRA TNFSF11
3 limbs/digits/tail MP:0005371 9.55 CALCR CTSK THBS1 THRA TNFSF11
4 neoplasm MP:0002006 9.43 CTSB ITGAV SPP1 THBS1 THRA TNFSF11
5 renal/urinary system MP:0005367 9.02 CTSB ITGAV SPP1 THBS1 THRA

Drugs & Therapeutics for Bone Giant Cell Tumor

Drugs for Bone Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1 615258-40-7
2 Bone Density Conservation Agents Phase 4,Phase 3,Phase 2,Phase 1
3 Immunoglobulins Phase 4,Phase 3,Phase 2
4 Antibodies, Monoclonal Phase 4,Phase 3,Phase 2
5 Immunoglobulin G Phase 4,Phase 2
6 Antibodies Phase 4,Phase 3,Phase 2
7 Immunologic Factors Phase 4,Phase 2,Early Phase 1
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
9
Phenol Approved, Experimental Phase 3 108-95-2 996
10
Zoledronic Acid Approved Phase 3,Phase 2,Phase 1 118072-93-8 68740
11
Ethanol Approved Phase 3 64-17-5 702
12 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
13 Adjuvants, Anesthesia Phase 3
14 Analgesics Phase 3
15 Liver Extracts Phase 3,Early Phase 1
16 Anesthetics, General Phase 3
17 Anesthetics Phase 3
18 Anesthetics, Intravenous Phase 3
19 Narcotics Phase 3
20 Cola Phase 3,Early Phase 1
21 Central Nervous System Depressants Phase 3
22 Peripheral Nervous System Agents Phase 3
23 Analgesics, Opioid Phase 3
24 Diphosphonates Phase 3
25 Polymethyl Methacrylate Phase 3
26
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
27
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
28
Calcium Approved, Nutraceutical Phase 2,Not Applicable 7440-70-2 271
29 Micronutrients Phase 2
30 Calcium, Dietary Phase 2,Not Applicable
31 Hormones Phase 2,Not Applicable
32 Nutrients Phase 2
33 Vitamins Phase 2
34 Trace Elements Phase 2
35 Calciferol Phase 2
36 Protein Kinase Inhibitors Phase 2
37 Pharmaceutical Solutions Phase 2,Phase 1
38
Parathyroid hormone Approved, Investigational Not Applicable 9002-64-6
39
Cyclophosphamide Approved, Investigational Early Phase 1 6055-19-2, 50-18-0 2907
40 Calcium Supplement
41 Antineoplastic Agents, Alkylating Early Phase 1
42 Immunosuppressive Agents Early Phase 1
43 Antirheumatic Agents Early Phase 1
44 Alkylating Agents Early Phase 1

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004 Active, not recruiting NCT03301857 Phase 4 Denosumab (Cohort A)
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Characteristics and Mechanism of Denosumab-treated Giant Cell Tumor of Bone Recruiting NCT03259152 Phase 3 Denosumab
4 Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone Recruiting NCT03295981 Phase 3 Zoledronic Acid
5 Study of Denosumab in Subjects With Giant Cell Tumor of Bone Completed NCT00680992 Phase 2 Denosumab
6 Safety and Efficacy Study of Denosumab in Patients With Recurrent or Unresectable Giant Cell Tumor of Bone Completed NCT00396279 Phase 2
7 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
8 Trial of Dasatinib in Advanced Sarcomas Completed NCT00464620 Phase 2 Dasatinib
9 Reduced Dose-density of Denosumab for Unresectable GCTB Not yet recruiting NCT03620149 Phase 2 Denosumab 120 MG/1.7 ML Subcutaneous Solution [XGEVA]
10 Adjuvant Zoledronic Acid in High Risk Giant Cell Tumour of Bone (GCT) Terminated NCT00889590 Phase 2 Zoledronic acid
11 Study of the Effect of Zoledronate on Local Recurrence After Surgical Treatment of Giant Cell Tumors of Bone Zométa Terminated NCT01564121 Phase 1, Phase 2 acid Zoledronic
12 Giant Cell Tumor of the Extremities Treated With Surgery and/or Medical Treatment Completed NCT02996734
13 Subtotal Parathyroidectomy or Total Parathyroidectomy With Autograft in Chronic Kidney Disease Patients Under Dialysis Active, not recruiting NCT02464072 Not Applicable
14 Safety and Efficacy of Post-operative Denosumab Strategy for Giant Cell Tumor of Bone Treatment in China Not yet recruiting NCT03358212 Denosumab
15 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Terminated NCT00499733 Early Phase 1 cyclophosphamide

Search NIH Clinical Center for Bone Giant Cell Tumor

Cochrane evidence based reviews: giant cell tumor of bone

Genetic Tests for Bone Giant Cell Tumor

Anatomical Context for Bone Giant Cell Tumor

MalaCards organs/tissues related to Bone Giant Cell Tumor:

42
Bone, Monocytes, Lung, Kidney, Lymph Node, Liver, Spinal Cord

Publications for Bone Giant Cell Tumor

Articles related to Bone Giant Cell Tumor:

(show top 50) (show all 580)
# Title Authors Year
1
Similar local recurrence but better function with curettage versus resection for bone giant cell tumor and pathological fracture at presentation. ( 30734307 )
2019
2
Effect of bisphosphonates on local recurrence of giant cell tumor of bone: a meta-analysis. ( 30666162 )
2019
3
Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage. ( 30675196 )
2019
4
Denosumab versus zoledronic acid in cases of surgically unsalvageable giant cell tumor of bone: A randomized clinical trial. ( 30740297 )
2019
5
Knock-down of oncohistone H3F3A-G34W counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells. ( 30742944 )
2019
6
A randomized phase III trial of denosumab before curettage for giant cell tumor of bone: Japan Clinical Oncology Group Study JCOG1610. ( 30796832 )
2019
7
Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone: A 1 to 12-Year Follow-up Study. ( 30811352 )
2019
8
Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone. ( 30844887 )
2019
9
Convolutional neural network to predict the local recurrence of giant cell tumor of bone after curettage based on pre-surgery magnetic resonance images. ( 30859281 )
2019
10
Denosumab treatment for giant-cell tumor of bone: a systematic review of the literature. ( 30877429 )
2019
11
In Vitro Study of the Effects of Denosumab on Giant Cell Tumor of Bone: Comparison with Zoledronic Acid. ( 29159783 )
2019
12
Osteonecrosis of the Jaw and Rebound Hypercalcemia in Young People Treated With Denosumab for Giant Cell Tumor of Bone. ( 29211870 )
2018
13
Retrospective investigation of "paint brush borders" sign in association with local recurrence of giant cell tumor of bone after intralesional curettage. ( 29255669 )
2018
14
Mid- to long-term clinical outcome of giant cell tumor of bone treated with calcium phosphate cement following thorough curettage and phenolization. ( 29315595 )
2018
15
Giant Cell Tumor of Bone in Patients 55 Years and Older: A Study of 34 Patients. ( 29425276 )
2018
16
Norcantharidin modulates the miR-30a/Metadherin/AKT signaling axis to suppress proliferation and metastasis of stromal tumor cells in giant cell tumor of bone. ( 29710674 )
2018
17
An extremely rare case of primary malignancy in giant cell tumor of bone, arising in the right femur and harboring H3F3A mutation. ( 29970305 )
2018
18
Detection of H3F3A p.G35W and p.G35R in giant cell tumor of bone by Allele Specific Locked Nucleic Acid quantitative PCR (ASLNAqPCR). ( 29254795 )
2018
19
Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy. ( 29757500 )
2018
20
Response evaluation of giant-cell tumor of bone treated by denosumab: Histogram and texture analysis of CT images. ( 29429890 )
2018
21
Osteoscopic Surgery of Giant Cell Tumor of Bone for Preservation of Proximal Fibula. ( 29715130 )
2018
22
Giant cell tumor of bone: updated molecular pathogenesis and tumor biology. ( 29944971 )
2018
23
Prognosis of metastatic giant cell tumor of bone in the pre-denosumab era. A systematic review and a meta-analysis. ( 29741702 )
2018
24
Magnetic resonance feature of "paintbrush borders" sign as a novel way to predict recurrence of giant cell tumor of bone after curettage: a pilot study. ( 29239274 )
2018
25
ALCAM+ stromal cells: role in giant cell tumor of bone progression. ( 29463803 )
2018
26
Expression of H3.3 G34W Distinguishes Giant Cell Tumor of Bone From Its Major Giant Cell-containing Bone and Soft Tissue Mimics, in Particular Aneurysmal Bone Cyst and Giant Cell Tumor of Soft Tissue. ( 29489506 )
2018
27
Primary thoracic giant cell tumor of bone sensitive to steroids. ( 29502130 )
2018
28
Denosumab May Increase the Risk of Local Recurrence in Patients with Giant-Cell Tumor of Bone Treated with Curettage. ( 29557866 )
2018
29
Giant Cell Tumor of Bone Presenting as Left Posteromedial Chest Wall Tumor. ( 29577929 )
2018
30
Denosumab treatment of inoperable or locally advanced giant cell tumor of bone - Multicenter analysis outside clinical trial. ( 29650420 )
2018
31
STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone. ( 29651441 )
2018
32
Incidence and demographics of giant cell tumor of bone in The Netherlands: First nationwide Pathology Registry Study. ( 29987945 )
2018
33
Safety and efficacy of denosumab in the treatment of pulmonary metastatic giant cell tumor of bone. ( 30013396 )
2018
34
Left orbital roof giant cell tumor of bone: A case report. ( 30034918 )
2018
35
Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study. ( 30089488 )
2018
36
Epidemiology of benign giant cell tumor of bone in the Chinese population. ( 30148063 )
2018
37
Intratibial injection of patient-derived tumor cells from giant cell tumor of bone elicits osteolytic reaction in nude mouse. ( 30214599 )
2018
38
Assessment of denosumab treatment effects and imaging response in patients with giant cell tumor of bone. ( 30231890 )
2018
39
Giant Cell Tumor of Bone: Review of Current Literature, Evaluation, and Treatment Options. ( 30449024 )
2018
40
Management of an Unusual Periprosthetic Giant Cell Tumor of Bone of the Proximal Tibia. ( 30465034 )
2018
41
Secondary malignant giant cell tumor of bone with histone H3.3 mutation: A case series. ( 30522923 )
2018
42
Stromal Cell-Derived CCL20 Promotes Tumor Progression and Osteolysis in Giant Cell Tumor of Bone. ( 30537747 )
2018
43
Preoperative Denosumab With Curettage and Cryotherapy in Giant Cell Tumor of Bone: Is There an Increased Risk of Local Recurrence? ( 30778015 )
2018
44
Malignant Sarcomatous Transformation of Benign Giant Cell Tumor of Bone after Treatment with Denosumab Therapy: A Literature Review of Reported Cases. ( 30868006 )
2018
45
Giant cell tumor of bone under Denosumab treatment. ( 28970075 )
2018
46
TRAIL-R1 as a novel surface marker for circulating giant cell tumor of bone. ( 28881598 )
2017
47
Osseous Myopericytoma Simulating a Giant Cell Tumor of Bone: A Case Report. ( 29244665 )
2017
48
Highly recurrent H3F3A mutations with additional epigenetic regulator alterations in giant cell tumor of bone. ( 28545165 )
2017
49
Transformation of Benign Giant Cell Tumor of Bone Into Epithelioid Angiosarcoma. ( 29309463 )
2017
50
Giant Cell Tumor of Bone and Other Giant Cell-Rich Lesions. ( 28750392 )
2017

Variations for Bone Giant Cell Tumor

Expression for Bone Giant Cell Tumor

Search GEO for disease gene expression data for Bone Giant Cell Tumor.

Pathways for Bone Giant Cell Tumor

GO Terms for Bone Giant Cell Tumor

Cellular components related to Bone Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.73 CTSB H3F3A ITGAV SERPINA3 SPP1 THBS1
2 extracellular space GO:0005615 9.7 CALCA CTSB CTSK SERPINA3 SPP1 THBS1
3 extracellular region GO:0005576 9.23 CALCA CTSB CTSK H3F3A SERPINA3 SPP1
4 endolysosome lumen GO:0036021 8.96 CTSB CTSK

Biological processes related to Bone Giant Cell Tumor according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.74 CALCA H3F3A SPP1
2 extracellular matrix organization GO:0030198 9.73 ITGAV SPP1 THBS1
3 positive regulation of protein kinase B signaling GO:0051897 9.67 CALCR THBS1 TNFSF11
4 inflammatory response GO:0006954 9.67 CALCA SERPINA3 SPP1 THBS1
5 positive regulation of cytosolic calcium ion concentration GO:0007204 9.63 CALCA CALCR ITGAV
6 monocyte chemotaxis GO:0002548 9.6 CALCA TNFSF11
7 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.59 ITGAV THBS1
8 regulation of heart contraction GO:0008016 9.58 CALCA THRA
9 collagen catabolic process GO:0030574 9.58 CTSB CTSK
10 activation of adenylate cyclase activity GO:0007190 9.55 CALCA CALCR
11 osteoclast differentiation GO:0030316 9.54 CALCR TNFSF11
12 positive regulation of phosphorylation GO:0042327 9.52 THBS1 TNFSF11
13 ERK1 and ERK2 cascade GO:0070371 9.51 ITGAV TNFSF11
14 decidualization GO:0046697 9.48 CTSB SPP1
15 negative regulation of ossification GO:0030279 9.43 CALCA CALCR
16 ossification GO:0001503 9.43 ACP5 THRA TNFSF11
17 positive regulation of bone resorption GO:0045780 9.4 SPP1 TNFSF11
18 negative regulation of interleukin-12 production GO:0032695 9.32 ACP5 THBS1
19 amylin receptor signaling pathway GO:0097647 9.16 CALCA CALCR
20 embryo implantation GO:0007566 8.96 CALCA SPP1
21 bone resorption GO:0045453 8.8 ACP5 CTSK TNFSF11

Molecular functions related to Bone Giant Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 9.33 ITGAV SPP1 THBS1
2 fibroblast growth factor binding GO:0017134 9.32 ITGAV THBS1
3 transforming growth factor beta binding GO:0050431 9.26 ITGAV THBS1
4 fibronectin binding GO:0001968 9.13 CTSK ITGAV THBS1
5 proteoglycan binding GO:0043394 8.8 CTSB CTSK THBS1
6 protein binding GO:0005515 10.11 CALCA CALCR CTSB CTSK H3F3A ITGAV

Sources for Bone Giant Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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