MCID: BNG036
MIFTS: 48

Bone Giant Cell Tumor

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Bone Giant Cell Tumor

MalaCards integrated aliases for Bone Giant Cell Tumor:

Name: Bone Giant Cell Tumor 12 15 17
Giant Cell Tumor of Bone 12 52 58 36 43 71
Osteoclastoma 12 52 58 54
Gct of Bone 52 58
Giant Cell Neoplasm of Bone 12
Giant Cell Myeloma 12

Classifications:

Orphanet: 58  
Rare bone diseases


External Ids:

Disease Ontology 12 DOID:4305
KEGG 36 H01470
MeSH 43 D018212
NCIt 49 C121932
SNOMED-CT 67 57500000
ICD10 via Orphanet 33 D48.0
UMLS via Orphanet 72 C0206638
Orphanet 58 ORPHA363976
UMLS 71 C0206638

Summaries for Bone Giant Cell Tumor

KEGG : 36 Giant-cell tumor of bone (GCTB) is a rare osteolytic tumor of the bone. Although classified as a benign tumor, GCTB is characterized by local aggressiveness and risk of local recurrence. Its name is derived from the numerous multinucleated giant cells found within the tumor, which are principally responsible for the extensive bone resorption that is characteristic of GCTB. However, the neoplastic components of GCTB are the spindle-like stromal cells, which produce RANKL that recruits monocytic osteoclast precursors from blood to the tumor, and stimulates differentiation into multinucleated giant cells. Recently, denosumab (RANKL inhibitor) has become a new treatment option for locally advanced GCTB.

MalaCards based summary : Bone Giant Cell Tumor, also known as giant cell tumor of bone, is related to bone giant cell sarcoma and epulis, and has symptoms including pain An important gene associated with Bone Giant Cell Tumor is ACP5 (Acid Phosphatase 5, Tartrate Resistant), and among its related pathways/superpathways are Presynaptic function of Kainate receptors and RANK Signaling in Osteoclasts. The drugs Denosumab and Antibodies, Monoclonal have been mentioned in the context of this disorder. Affiliated tissues include bone, monocytes and lung, and related phenotypes are cellular and hematopoietic system

Disease Ontology : 12 A giant cell tumor and bone cancer and bone tissue neoplasm that results in the presence of multinucleated giant cells (osteoclast-like cell).

Wikipedia : 74 Giant-cell tumor of the bone (GCTOB), is a relatively uncommon tumor of the bone. It is characterized by... more...

Related Diseases for Bone Giant Cell Tumor

Diseases related to Bone Giant Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 227, show less)
# Related Disease Score Top Affiliating Genes
1 bone giant cell sarcoma 31.9 USP6 SH3BP2 H3-3B H3-3A
2 epulis 30.9 SERPINA3 CD68
3 aneurysmal bone cysts 30.5 USP6 TNFSF11 TNFRSF11A CALCA
4 fibroma 30.4 USP6 SERPINA3 CD68
5 fibrous dysplasia 30.3 SPP1 SH3BP2 CALCA
6 osteomyelitis 30.3 TNFSF11 CTSK CALCA ACP5
7 bone inflammation disease 30.2 TNFSF11 TNFRSF11B SERPINA3 ACP5
8 villonodular synovitis 30.1 TNFSF11 CD68 ACP5
9 telangiectatic osteogenic sarcoma 30.1 USP6 H3-3B H3-3A
10 osteonecrosis 30.0 TNFSF11 TNFRSF11B PTH ACP5
11 osteomalacia 30.0 TNFSF11 PTH CALCA
12 grade iii astrocytoma 30.0 THBS1 H3-3B H3-3A CTSB
13 multicentric carpotarsal osteolysis syndrome 29.9 TNFSF11 TNFRSF11B TNFRSF11A
14 malignant giant cell tumor 29.9 H3-3B H3-3A CD68
15 cherubism 29.8 USP6 TNFSF11 SH3BP2 CALCA
16 osteogenic sarcoma 29.8 TNFSF11 TNFRSF11B SPP1 PTH CALCRL
17 secondary hyperparathyroidism 29.8 TNFRSF11B PTH CALCA ACP5
18 chondroblastoma 29.7 TNFSF11 SERPINA3 H3-3B H3-3A
19 primary hyperparathyroidism 29.7 TNFSF11 TNFRSF11B PTH CALCA
20 hyperparathyroidism 29.6 TNFSF11 TNFRSF11B PTH CALCA ACP5
21 arthritis 29.5 TNFSF11 TNFRSF11A PTH CTSK ACP5
22 synovitis 29.5 TNFSF11 TNFRSF11B CD68 ACP5
23 connective tissue benign neoplasm 29.4 USP6 SERPINA3 PTH CD68
24 bone resorption disease 29.2 TNFSF11 TNFRSF11B TNFRSF11A SPP1 PTH CTSK
25 endosteal hyperostosis, autosomal dominant 29.2 TNFSF11 TNFRSF11B SH3BP2 PTH CTSK ACP5
26 bone cancer 29.0 TNFSF11 TNFRSF11B TNFRSF11A SERPINA3 CALCA
27 pigmented villonodular synovitis 29.0 TNFSF11 TNFRSF11B SERPINA3 CD68 CALCR ACP5
28 mammary paget's disease 28.9 TNFSF11 TNFRSF11B TNFRSF11A PTH CTSK CALCA
29 osteopetrosis 28.7 TNFSF11 TNFRSF11B TNFRSF11A CTSK CALCR CALCA
30 paget's disease of bone 28.3 ZNF687 TNFSF11 TNFRSF11B TNFRSF11A PTH CALCA
31 bone disease 28.2 TNFSF11 TNFRSF11B TNFRSF11A SPP1 PTH CTSK
32 giant cell tumor 27.9 ZNF687 TNFSF11 TNFRSF11B TNFRSF11A SERPINA3 H3-3B
33 giant cell reparative granuloma 26.7 USP6 TNFSF11 TNFRSF11A SH3BP2 SERPINA3 PTH
34 paget disease of bone 6 11.3
35 clear cell adenoma 10.4 PTH CALCR
36 diffuse intrinsic pontine glioma 10.4 H3-3B H3-3A
37 adult brain stem glioma 10.4 H3-3B H3-3A
38 histiocytoma 10.3
39 fibrous histiocytoma 10.3
40 undifferentiated pleomorphic sarcoma 10.3
41 nodular tenosynovitis 10.3 SERPINA3 CD68
42 congenital epulis 10.3 SERPINA3 CD68
43 spinal cord astrocytoma 10.3 H3-3B H3-3A
44 malignant fibroxanthoma 10.3
45 pilocytic astrocytoma of cerebellum 10.3 H3-3B H3-3A
46 xanthogranulomatous pyelonephritis 10.3 SERPINA3 CD68
47 cerebellar astrocytoma 10.3 SERPINA3 H3-3B
48 hypercalcemia, infantile, 1 10.3 PTH CALCA
49 inflammatory mfh 10.3 SERPINA3 CD68
50 reticulohistiocytic granuloma 10.3 SERPINA3 CD68
51 pancreas sarcoma 10.3 SERPINA3 CD68
52 bone leiomyosarcoma 10.3 TNFSF11 CD68
53 hypervitaminosis d 10.3 PTH CALCA
54 adult oligodendroglioma 10.3 H3-3B H3-3A
55 malignant granular cell myoblastoma 10.3 SERPINA3 CD68
56 papillary cystadenocarcinoma 10.3 SPP1 SERPINA3
57 xanthogranulomatous cholecystitis 10.3 SERPINA3 CD68
58 liver sarcoma 10.3 SERPINA3 CD68
59 childhood oligodendroglioma 10.3 H3-3B H3-3A
60 malignant giant cell tumor of soft parts 10.2 CD68 ACP5
61 histiocytic and dendritic cell cancer 10.2 SERPINA3 CD68
62 non-langerhans-cell histiocytosis 10.2 SERPINA3 CD68
63 malignant ovarian brenner tumor 10.2 TNFSF11 PTH CALCA
64 periodontitis, chronic 10.2 TNFSF11 TNFRSF11B
65 verruciform xanthoma of skin 10.2 SERPINA3 CTSB CD68
66 gorham's disease 10.2 TNFSF11 PTH CALCA
67 clear cell chondrosarcoma 10.2 SERPINA3 H3-3B H3-3A
68 chondroblastic osteosarcoma 10.2 SERPINA3 H3-3B H3-3A
69 endemic goiter 10.2 PTH CALCA
70 epidermolytic acanthoma 10.2 CTSB CD68
71 ossifying fibroma 10.2
72 fibrosarcoma 10.2
73 spindle cell sarcoma 10.2
74 osteonecrosis of the jaw 10.2
75 pleomorphic xanthoastrocytoma 10.2 SERPINA3 H3-3B H3-3A
76 endocrine organ benign neoplasm 10.2 SERPINA3 PTH CALCA
77 colon leiomyoma 10.2 H3-3B H3-3A
78 neuroma 10.2 SERPINA3 CD68 CALCA
79 chronic apical periodontitis 10.1 TNFSF11 TNFRSF11B
80 calcinosis 10.1 SPP1 PTH CALCA
81 chondrosarcoma 10.1
82 sarcoma 10.1
83 rapidly involuting congenital hemangioma 10.1
84 vascular cancer 10.1 THBS1 SERPINA3 CD68
85 osteopetrosis, autosomal recessive 2 10.1 TNFSF11 ACP5
86 childhood pilocytic astrocytoma 10.1 H3-3B H3-3A
87 hyperthyroidism 10.1 PTH CALCA ACP5
88 hairy cell leukemia 10.1
89 kummell's disease 10.1 TNFSF11 TNFRSF11B
90 tenosynovial giant cell tumor 10.1 SERPINA3 CD68
91 osteoblastoma 10.1
92 mesenchymal cell neoplasm 10.1
93 48,xyyy 10.1
94 ring chromosome 10.1
95 teeth hard tissue disease 10.1 TNFSF11 TNFRSF11B ACP5
96 breast leiomyosarcoma 10.1 TNFSF11 TNFRSF11A
97 adult astrocytic tumour 10.1 H3-3B H3-3A
98 hypersensitivity reaction type iv disease 10.1 SERPINA3 PTH CD68
99 gingival disease 10.0 TNFSF11 TNFRSF11B SERPINA3
100 nephrolithiasis, calcium oxalate 10.0 SPP1 PTH CALCR CALCA
101 proliferative fasciitis 10.0 USP6 SERPINA3 CD68
102 gliosarcoma 10.0 SERPINA3 H3-3B H3-3A CTSB
103 odontochondrodysplasia 10.0 TNFSF11 SPP1 PTH CTSK
104 pseudosarcomatous fibromatosis 10.0 USP6 SERPINA3 CD68
105 liposarcoma 10.0
106 histiocytosis 10.0
107 rare disease in surgical orthopedic 10.0
108 overgrowth syndrome 10.0
109 periapical periodontitis 10.0 TNFSF11 TNFRSF11B CTSK ACP5
110 otosclerosis 10.0 TNFSF11 TNFRSF11B CALCA
111 neurofibromatosis, type i 10.0
112 neurofibromatosis, type iv, of riccardi 10.0
113 neuropathy, congenital hypomyelinating, 2 10.0
114 ptosis 10.0
115 bacterial infectious disease 10.0
116 thyroid gland cancer 10.0
117 transitional cell carcinoma 10.0
118 astrocytoma 10.0
119 papillary carcinoma 10.0
120 osteitis fibrosa 10.0
121 fibrosarcoma of bone 10.0
122 papillary transitional carcinoma 10.0
123 severe combined immunodeficiency 10.0
124 in situ carcinoma 10.0
125 neurofibroma 10.0
126 enchondroma 10.0
127 dysphagia 10.0
128 hyperphosphatemia 10.0 TNFRSF11B SPP1 PTH
129 van buchem disease 9.9 TNFSF11 TNFRSF11B PTH
130 spinal cord glioma 9.9 H3-3B H3-3A
131 tympanosclerosis 9.9 SPP1 CALCA
132 spondyloarthropathy 1 9.9 TNFSF11 TNFRSF11B PTH
133 uremia 9.9 TNFRSF11B SPP1 PTH
134 polyarticular onset juvenile idiopathic arthritis 9.9 TNFSF11 TNFRSF11B TNFRSF11A
135 hemophilic arthropathy 9.9 TNFSF11 TNFRSF11B TNFRSF11A
136 arthropathy 9.9 TNFSF11 TNFRSF11B TNFRSF11A
137 aortic valve disease 2 9.9 TNFSF11 TNFRSF11B SPP1 SERPINA3
138 familial expansile osteolysis 9.9 TNFSF11 TNFRSF11B TNFRSF11A
139 renal cell carcinoma, nonpapillary 9.8
140 oculodentodigital dysplasia 9.8
141 sarcoma, synovial 9.8
142 focal dermal hypoplasia 9.8
143 langerhans cell histiocytosis 9.8
144 meningioma, radiation-induced 9.8
145 meningioma, familial 9.8
146 myxoid liposarcoma 9.8
147 angiosarcoma 9.8
148 exanthem 9.8
149 paraganglioma 9.8
150 arteriovenous malformation 9.8
151 spinal meningioma 9.8
152 hypophosphatemia 9.8
153 retinitis pigmentosa 11 9.8
154 pulmonary arteriovenous fistulas 9.8
155 strabismus 9.8
156 polykaryocytosis inducer 9.8
157 leukemia 9.8
158 hypophosphatasia 9.8
159 patellofemoral pain syndrome 9.8
160 squamous cell carcinoma 9.8
161 melanoma 9.8
162 leiomyosarcoma 9.8
163 pleomorphic adenoma carcinoma 9.8
164 juxtacortical osteosarcoma 9.8
165 plague 9.8
166 choriocarcinoma 9.8
167 plexopathy 9.8
168 spindle cell carcinoma 9.8
169 amelanotic melanoma 9.8
170 hypokalemia 9.8
171 pleomorphic adenoma 9.8
172 secretory meningioma 9.8
173 lymphoplasmacyte-rich meningioma 9.8
174 pulmonary coin lesion 9.8
175 adenoma 9.8
176 peroneal nerve paralysis 9.8
177 parathyroid adenoma 9.8
178 osteoarthritis 9.8
179 mechanical strabismus 9.8
180 exophthalmos 9.8
181 aminoaciduria 9.8
182 brain tumor, childhood 9.8
183 germ cells tumors 9.8
184 juvenile ossifying fibroma 9.8
185 oncogenic osteomalacia 9.8
186 pulmonary arteriovenous malformation 9.8
187 radiation induced cancer 9.8
188 ring chromosome 11 9.8
189 sacral plexopathy 9.8
190 soft tissue sarcoma 9.8
191 back pain 9.8
192 bone sarcoma 9.8
193 myopericytoma 9.8
194 chondromyxoid fibroma 9.8
195 avascular necrosis 9.8
196 argyria 9.8
197 thyroid carcinoma 9.8
198 sclerosteosis 9.8 TNFSF11 TNFRSF11B PTH CTSK
199 osteoporosis, juvenile 9.8 TNFSF11 TNFRSF11B PTH CALCA
200 scoliosis 9.8
201 mastoiditis 9.8
202 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.8
203 chordoma 9.8
204 triiodothyronine receptor auxiliary protein 9.8
205 thrombophilia due to thrombin defect 9.8
206 chondroma 9.8
207 47,xyy 9.8
208 rare tumor 9.8
209 bone benign neoplasm 9.8 USP6 SH3BP2 SERPINA3 PTH
210 breast adenocarcinoma 9.8 TNFSF11 THBS1 SERPINA3 CTSK CTSB CALCA
211 multicentric reticulohistiocytosis 9.8 TNFSF11 TNFRSF11B SERPINA3 CD68
212 paget disease of bone 5, juvenile-onset 9.7 TNFSF11 TNFRSF11B TNFRSF11A CALCA
213 glucocorticoid-induced osteoporosis 9.7 TNFSF11 TNFRSF11B PTH CALCA ACP5
214 renal osteodystrophy 9.7 TNFSF11 TNFRSF11B PTH CALCA ACP5
215 parathyroid gland disease 9.7 TNFSF11 TNFRSF11B PTH CALCA ACP5
216 mineral metabolism disease 9.6 TNFSF11 TNFRSF11B SPP1 PTH CALCA
217 chronic kidney disease 9.6 TNFSF11 TNFRSF11B SPP1 PTH ACP5
218 myeloma, multiple 9.5 TNFSF11 TNFRSF11B SPP1 PTH CTSK ACP5
219 periodontitis 9.4 TNFSF11 TNFRSF11B TNFRSF11A SPP1 CTSK ACP5
220 brittle bone disorder 9.4 TNFSF11 TNFRSF11B SPP1 PTH CTSK CALCA
221 root resorption 9.2 TNFSF11 TNFRSF11B TNFRSF11A SPP1 CTSK CALCR
222 connective tissue disease 9.2 TNFSF11 TNFRSF11B SPP1 SERPINA3 PTH CTSK
223 tooth resorption 9.0 TNFSF11 TNFRSF11B TNFRSF11A SPP1 SH3BP2 CTSK
224 ischemic bone disease 9.0 TNFSF11 TNFRSF11B TNFRSF11A SPP1 PTH CTSK
225 bone remodeling disease 8.8 TNFSF11 TNFRSF11B TNFRSF11A SPP1 PTH CTSK
226 osteoporosis 8.8 TNFSF11 TNFRSF11B TNFRSF11A SPP1 PTH CTSK
227 rheumatoid arthritis 8.8 TNFSF11 TNFRSF11B TNFRSF11A SPP1 SERPINA3 PTH

Graphical network of the top 20 diseases related to Bone Giant Cell Tumor:



Diseases related to Bone Giant Cell Tumor

Symptoms & Phenotypes for Bone Giant Cell Tumor

UMLS symptoms related to Bone Giant Cell Tumor:


pain

MGI Mouse Phenotypes related to Bone Giant Cell Tumor:

45 (showing 7, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 CALCRL CTSB CTSK H3-3B PTH SH3BP2
2 hematopoietic system MP:0005397 10.03 CALCR CALCRL CD68 CTSK PTH SH3BP2
3 craniofacial MP:0005382 9.97 CTSK PTH SH3BP2 SPP1 THRA TNFRSF11A
4 immune system MP:0005387 9.97 CALCR CALCRL CD68 CTSB CTSK PTH
5 digestive/alimentary MP:0005381 9.87 CALCRL CTSB CTSK SH3BP2 THBS1 THRA
6 limbs/digits/tail MP:0005371 9.61 CALCR CTSK PTH SH3BP2 THBS1 THRA
7 skeleton MP:0005390 9.36 CALCR CD68 CTSK PTH SH3BP2 SPP1

Drugs & Therapeutics for Bone Giant Cell Tumor

Drugs for Bone Giant Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 53, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Denosumab Approved Phase 4 615258-40-7
2 Antibodies, Monoclonal Phase 4
3 Antibodies Phase 4
4 Immunoglobulins Phase 4
5 Immunoglobulin G Phase 4
6
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
7
Ethanol Approved Phase 3 64-17-5 702
8
Phenol Approved, Experimental Phase 3 108-95-2 996
9 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
10 Analgesics Phase 3
11 Liver Extracts Phase 3
12 Cola Phase 3
13 Narcotics Phase 3
14 Anesthetics Phase 3
15 Anesthetics, General Phase 3
16 Analgesics, Opioid Phase 3
17 Adjuvants, Anesthesia Phase 3
18 Central Nervous System Depressants Phase 3
19 Anesthetics, Intravenous Phase 3
20 Polymethyl Methacrylate Phase 3
21 Diphosphonates Phase 3
22
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
23
Fludarabine Approved Phase 2 21679-14-1, 75607-67-9 30751
24
Vidarabine Approved, Investigational Phase 2 24356-66-9 32326 21704
25
Aldesleukin Approved Phase 2 110942-02-4, 85898-30-2
26
Zoledronic Acid Approved Phase 2 118072-93-8 68740
27
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2 1406-16-2
28
Emodepside Investigational, Vet_approved Phase 2 155030-63-0
29 Micronutrients Phase 2
30 Trace Elements Phase 2
31 Vitamins Phase 2
32 Nutrients Phase 2
33 Calciferol Phase 2
34 Hormones Phase 2
35 Protein Kinase Inhibitors Phase 2
36 Interleukin-2 Phase 2
37 Anti-Infective Agents Phase 2
38 Anti-Retroviral Agents Phase 2
39 Analgesics, Non-Narcotic Phase 2
40 Antiviral Agents Phase 2
41 Antimetabolites Phase 2
42 Anti-HIV Agents Phase 2
43 Vidarabine Phosphate Phase 2
44 Pharmaceutical Solutions Phase 1, Phase 2
45
Serine Investigational, Nutraceutical Phase 2 56-45-1 5951
46
Cyclophosphamide Approved, Investigational Early Phase 1 50-18-0, 6055-19-2 2907
47
Calcium Approved, Nutraceutical 7440-70-2 271
48 Calcium, Dietary
49 Calcium Supplement
50 Alkylating Agents Early Phase 1
51 Antirheumatic Agents Early Phase 1
52 Immunosuppressive Agents Early Phase 1
53 Immunologic Factors Early Phase 1

Interventional clinical trials:

(showing 16, show less)
# Name Status NCT ID Phase Drugs
1 Long-term Safety Follow-up of Subjects With Giant Cell Tumor of Bone Treated With Denosumab in Study 20062004 Active, not recruiting NCT03301857 Phase 4 Denosumab (Cohort A)
2 Clinical, Pathologic Characteristics and Its Mechansim of Denosumab Treated Giant Cell Tumor of Bone Unknown status NCT03259152 Phase 3 Denosumab
3 A Randomized, Double-blind, Placebo-controlled Multi-center Study to Evaluate the Safety and Efficacy of Fentanyl Sublingual Spray (Fentanyl SL Spray) for the Treatment of Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone: A Prospective Randomized Controlled Trial Recruiting NCT03295981 Phase 3 Zoledronic Acid
5 An Open-Label, Multi-Center, Phase 2 Safety and Efficacy Study of Denosumab (AMG 162) in Subjects With Recurrent or Unresectable Giant Cell Tumor (GCT) of Bone Completed NCT00396279 Phase 2
6 An Open-label, Multi-center, Phase 2 Study of Denosumab in Subjects With Giant Cell Tumor of Bone Completed NCT00680992 Phase 2 Denosumab
7 A Phase II Trial of Dasatinib in Advanced Sarcomas Completed NCT00464620 Phase 2 Dasatinib
8 Denosumab: A Potential Treatment Option for Aneurysmal Bone Cysts Completed NCT03415477 Phase 1, Phase 2 Denosumab (Xgeva)
9 Reduced Dose-density of Denosumab for Maintenance Therapy of Unresectable Giant Cell Tumor of Bone: a Multicenter Phase II Study "REDUCE" Recruiting NCT03620149 Phase 2 Denosumab 120 MG/1.7 ML Subcutaneous Solution [XGEVA]
10 Clinical Study to Assess Efficacy and Safety of LN-145 (Autologous Centrally Manufactured Tumor Infiltrating Lymphocytes) Across Multiple Tumor Types Recruiting NCT03449108 Phase 2 Cyclophosphamide;Fludarabine;Fludarabine Phosphate
11 Adjuvant Zoledronic Acid in 'High Risk' Giant Cell Tumour of Bone (GCT) - A Randomized Phase II Study Terminated NCT00889590 Phase 2 Zoledronic acid
12 Phase 2 Study of the Effect of Zoledronate on Local Recurrence After Surgical Treatment of Giant Cell Tumors of Bone Terminated NCT01564121 Phase 1, Phase 2 acid Zoledronic
13 Il Tumore a Cellule Giganti Delle estermità Completed NCT02996734
14 Giant Cell Tumor of the Bone in Patients Under 15 Years Old: a Single Institution Case-series Recruiting NCT04002817
15 Safety and Efficacy of Post-operative Denosumab Strategy for Giant Cell Tumor of Bone Treatment in China:Correlation Between Recurrence and Drug Withdrawl Not yet recruiting NCT03358212 Denosumab
16 Sequential Administration of Cryoablation and Cyclophosphamide for Advanced Solid Epithelial Cancer Terminated NCT00499733 Early Phase 1 cyclophosphamide

Search NIH Clinical Center for Bone Giant Cell Tumor

Cochrane evidence based reviews: giant cell tumor of bone

Genetic Tests for Bone Giant Cell Tumor

Anatomical Context for Bone Giant Cell Tumor

MalaCards organs/tissues related to Bone Giant Cell Tumor:

40
Bone, Monocytes, Lung, Breast, Pancreas, Liver, Thyroid

Publications for Bone Giant Cell Tumor

Articles related to Bone Giant Cell Tumor:

(showing 1080, show less)
# Title Authors PMID Year
1
[Evaluation of total scapular arthroplasty after total scapulectomy for scapular tumors]. 61
32030948 2020
2
Giant cell tumor of soft tissue of the breast: Case report with H3F3A mutation analysis and review of the literature. 61
31784095 2020
3
Simvastatin Possesses Antitumor and Differentiation-Promoting Properties That Affect Stromal Cells in Giant Cell Tumor of Bone. 61
31471919 2020
4
Implanted β-Tricalcium Phosphate Blocks Can Function as a Placeholder in Recurrent Giant Cell Tumor of Bone. 61
32015922 2020
5
Curettage as first surgery for bone giant cell tumor : adequate surgery is more important than oncology training or surgical management by high volume specialized teams. 61
31520122 2020
6
Denosumab-treated Giant Cell Tumors of Bone: A Clinicopathologic Analysis of 35 Cases From the French Group of Bone Pathology. 61
31651524 2020
7
Functional Outcomes After Sauve-Kapandji Arthrodesis. 61
31948706 2020
8
Soft Tissue Special Issue: Giant Cell-Rich Lesions of the Head and Neck Region. 61
31950466 2020
9
Immunohistochemical analysis of 36 cases of chondroblastomas: A single institutional experience. 61
31862519 2019
10
Short-term Preoperative Denosumab With Surgery in Unresectable or Recurrent Giant Cell Tumor of Bone. 61
31762217 2019
11
Absence of H3F3A mutation in a subset of malignant giant cell tumor of bone. 61
31285528 2019
12
Denosumab Therapy Obscures Histological Features of Giant Cell Tumor of Bone. 61
31665371 2019
13
Survival and prognosis in malignant giant cell tumor of bone: A population-based analysis from 1984 to 2013. 61
31667061 2019
14
Epidemiologic Characteristics, Clinical Behavior, and Outcome of the Giant Cell Tumor of the Bone: A Retrospective Single-center Study. 61
31970259 2019
15
A case of pelvic giant cell tumor of bone, complete remission with denosumab: long duration of response. 61
31743134 2019
16
Denosumab and Sunitinib in the treatment of giant-cell tumor of bone with pulmonary and bone metastases in an adolescent: A case report. 61
31725619 2019
17
Is Treatment with Denosumab Associated with Local Recurrence in Patients with Giant Cell Tumor of Bone Treated with Curettage? A Systematic Review. 61
31794487 2019
18
Present day controversies and consensus in curettage for giant cell tumor of bone. 61
31736607 2019
19
Histone H3.3 mutation in giant cell tumor of bone: an update in pathology. 61
31748824 2019
20
Utility of FOS as diagnostic marker for osteoid osteoma and osteoblastoma. 61
31768625 2019
21
Role of intravenous zoledronic acid in management of giant cell tumor of bone- A prospective, randomized, clinical, radiological and electron microscopic analysis. 61
31736608 2019
22
Surgical resection and reconstructive techniques using autologous femoral head bone-grafting in treating partial acetabular defects arising from primary pelvic malignant tumors. 61
31627719 2019
23
Use of Denosumab in Children With Osteoclast Bone Dysplasias: Report of Three Cases. 61
31687646 2019
24
Denosumab treatment for giant-cell tumor of bone: a systematic review of the literature. 61
30877429 2019
25
Plasma metabolite profiling reveals potential biomarkers of giant cell tumor of bone by using NMR-based metabolic profiles: A cross-sectional study. 61
31577769 2019
26
Convolutional neural network to predict the local recurrence of giant cell tumor of bone after curettage based on pre-surgery magnetic resonance images. 61
30859281 2019
27
In situ cell cycle analysis in giant cell tumor of bone reveals patients with elevated risk of reduced progression-free survival. 61
31233932 2019
28
A new computerized tomography classification to evaluate response to Denosumab in giant cell tumors in the extremities. 61
31253385 2019
29
Retrospective Audit of Various Surgical Modalities Adopted for Giant Cell Tumor in a Rural Tertiary Cancer Center. 61
31496597 2019
30
Reconstruction with β-tricalcium phosphate for giant cell tumor of the talus. 61
31743864 2019
31
Evaluation of Local Recurrence in Giant-Cell Tumor of Bone Treated by Neoadjuvant Denosumab. 61
31475058 2019
32
A posterior approach for curettage in giant cell tumor of bone in the proximal fibula. 61
31548873 2019
33
Validation of Fluorescence in situ Hybridization Testing of USP6 Gene Rearrangement for Diagnosis of Primary Aneurysmal Bone Cyst. 61
31611201 2019
34
Clinical Significance of MRI and Pathological Features of Giant Cell Tumor of Bone Boundary. 61
31422584 2019
35
[The study of the value of H3F3A G34W immunohistochemical staining in the diagnosis of giant cell tumor of bone]. 61
31288308 2019
36
Challenges of denosumab in giant cell tumor of bone, and other giant cell-rich tumors of bone. 61
30844887 2019
37
Adjuvant Zoledronic Acid in High-Risk Giant Cell Tumor of Bone: A Multicenter Randomized Phase II Trial. 61
31040253 2019
38
Giant cell tumour of the bone treated with denosumab: How has the blood supply and oncological prognosis of the tumour changed? 61
31508313 2019
39
Morphologic Changes After Denosumab Therapy in Patients with Giant Cell Tumor of the Spine: Report of Four Cases and a Review of the Literature. 61
30926552 2019
40
Similar local recurrence but better function with curettage versus resection for bone giant cell tumor and pathological fracture at presentation. 61
30734307 2019
41
Preoperative Denosumab plus Surgery in the Management of Giant Cell Tumor of Bone: A Comprehensive Narrative Literature Review. 61
31242985 2019
42
Intra-articular ectopic ossification associated with denosumab administration for giant cell tumor of bone with intra-articular pathological fracture. 61
28109658 2019
43
Denosumab versus zoledronic acid in cases of surgically unsalvageable giant cell tumor of bone: A randomized clinical trial. 61
30740297 2019
44
Knock-down of oncohistone H3F3A-G34W counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells. 61
30742944 2019
45
Characterization of Three Novel H3F3A-mutated Giant Cell Tumor Cell Lines and Targeting of Their Wee1 Pathway. 61
31015476 2019
46
A randomized phase III trial of denosumab before curettage for giant cell tumor of bone: Japan Clinical Oncology Group Study JCOG1610. 61
30796832 2019
47
The prognostic significance of the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio in giant cell tumor of the extremities. 61
30961549 2019
48
Measurement of morphological parameters of giant cell tumor of bone in the knee. 61
30930988 2019
49
Giant Cell Tumor of Bone: Review of Current Literature, Evaluation, and Treatment Options. 61
30449024 2019
50
Treatment of Massive Giant Cell Tumor of Bone of the Proximal Radius. Case Study. 61
31180037 2019
51
An unusual case of giant cell tumor of soft parts in an American Warmblood horse. 61
31086765 2019
52
Giant Cell Tumor of the Carotid Body: A Rare Tumor in a Novel Location. 61
30922105 2019
53
Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone: A 1 to 12-Year Follow-up Study. 61
30811352 2019
54
Managements of giant cell tumor within the distal radius: A retrospective study of 58 cases from a single center. 61
30705814 2019
55
Tumor immunohistochemistry and preoperative magnetic resonance imaging features predict local recurrence of giant cell tumor of bone following intralesional curettage. 61
30675196 2019
56
Recurrent Adolescent Giant-Cell Tumor of the Scaphoid: Scaphoid Excision with Intracarpal Fusion after Failed Curettage and Bone Grafting. 61
31093399 2019
57
In Vitro Study of the Effects of Denosumab on Giant Cell Tumor of Bone: Comparison with Zoledronic Acid. 61
29159783 2019
58
Histopathology of giant cell tumors of the bone: With special emphasis on fibrohistiocytic and aneurysmal bone cyst like components. 61
30392920 2019
59
Effect of bisphosphonates on local recurrence of giant cell tumor of bone: a meta-analysis. 61
30666162 2019
60
Malignancy in Giant Cell Tumor of Bone: A Review of the Literature. 61
30935298 2019
61
Secondary Malignant Transformation of Giant Cell Tumor of Bone: Is It a Fate? 61
31528174 2019
62
Giant cell tumor of bone: Unusual features of a rare tumor. 61
31598208 2019
63
Role of Bisphosphonates as Adjuvants of Surgery in Giant Cell Tumor of Spine. 61
30619673 2018
64
Secondary malignant giant cell tumor of bone with histone H3.3 mutation: A case series. 61
30522923 2018
65
Malignant Sarcomatous Transformation of Benign Giant Cell Tumor of Bone after Treatment with Denosumab Therapy: A Literature Review of Reported Cases. 61
30868006 2018
66
Neoadjuvant and Adjuvant Treatment with Denosumab in Aggressive Giant-cell Tumor of Bone in the Proximal Fibula: a Case Report. 61
31188771 2018
67
MHRA Drug Safety Update: denosumab (Xgeva) and rebound hypercalcaemia. 61
30297446 2018
68
A novel subchondral bone-grafting procedure for the treatment of giant-cell tumor around the knee: A retrospective study of 27 cases. 61
30407342 2018
69
Long-term Follow-up of the Use of a Synthetic Bone Graft Composite in the Surgical Management of Primary Bone Tumors. 61
30371921 2018
70
Diagnostic Immunohistochemistry for Soft Tissue and Bone Tumors: An Update. 61
30134255 2018
71
Giant cell tumor of bone: updated molecular pathogenesis and tumor biology. 61
29944971 2018
72
Primary thoracic giant cell tumor of bone sensitive to steroids. 61
29502130 2018
73
Intratibial injection of patient-derived tumor cells from giant cell tumor of bone elicits osteolytic reaction in nude mouse. 61
30214599 2018
74
Denosumab in patients with aneurysmal bone cysts: A case series with preliminary results. 61
30086700 2018
75
Incidence and demographics of giant cell tumor of bone in The Netherlands: First nationwide Pathology Registry Study. 61
29987945 2018
76
An extremely rare case of primary malignancy in giant cell tumor of bone, arising in the right femur and harboring H3F3A mutation. 61
29970305 2018
77
[H3F3A mutated multicentric giant cell tumor of bone : A very rare primary bone disease]. 61
30046846 2018
78
Denosumab treatment of inoperable or locally advanced giant cell tumor of bone - Multicenter analysis outside clinical trial. 61
29650420 2018
79
Preoperative Denosumab With Curettage and Cryotherapy in Giant Cell Tumor of Bone: Is There an Increased Risk of Local Recurrence? 61
30778015 2018
80
Management of an Unusual Periprosthetic Giant Cell Tumor of Bone of the Proximal Tibia. 61
30465034 2018
81
Assessment of denosumab treatment effects and imaging response in patients with giant cell tumor of bone. 61
30231890 2018
82
Epidemiology of benign giant cell tumor of bone in the Chinese population. 61
30148063 2018
83
Giant Cell Tumor of the Frontal Bone: A Case Report and Literature Review. 61
30483457 2018
84
Giant Cell Tumor of Bone Presenting as Left Posteromedial Chest Wall Tumor. 61
29577929 2018
85
Immunohistochemistry for histone H3G34W and H3K36M is highly specific for giant cell tumor of bone and chondroblastoma, respectively, in FNA and core needle biopsy. 61
29757500 2018
86
Clinical outcome of primary giant cell tumor of bone after curettage with or without perioperative denosumab in Japan: from a questionnaire for JCOG 1610 study. 61
30089488 2018
87
Norcantharidin modulates the miR-30a/Metadherin/AKT signaling axis to suppress proliferation and metastasis of stromal tumor cells in giant cell tumor of bone. 61
29710674 2018
88
Matrix metalloproteinase-9 expression of GCTSC in peripheral tissue and central tissue of GCTB. 61
29600575 2018
89
Expression of MMP-2 and TIMP-3 with incidence and prognosis of giant-cell tumor of the bone. 61
29963137 2018
90
Prognosis of metastatic giant cell tumor of bone in the pre-denosumab era. A systematic review and a meta-analysis. 61
29741702 2018
91
Diagnostic tools in the differential diagnosis of giant cell-rich lesions of bone at biopsy. 61
30046391 2018
92
[Treatment of proximal femoral benign lesions by proximal femoral nail anti-rotation combined with curettage and bone graft through the Watson-Jones approach]. 61
30129314 2018
93
Primary malignancy in giant cell tumor of thoracic vertebrae: A case report. 61
29995810 2018
94
Denosumab in Patients with Giant Cell Tumor and Its Recurrence: A Systematic Review. 61
30175172 2018
95
Giant cell tumor of bone under Denosumab treatment. 61
28970075 2018
96
Fortuitous administration of denosumab in breast carcinoma with osteoclastic giant cells. 61
29481473 2018
97
[Clinical, radiologic and pathologic features of giant cell tumor of bone treated with denosumab]. 61
29886590 2018
98
USP6 gene rearrangement differentiates primary paranasal sinus solid aneurysmal bone cyst from other giant cell-rich lesions: report of a rare case. 61
29217425 2018
99
Characteristics of Benign and Malignant Bone Tumors Registered in the Hiroshima Tumor Tissue Registry, 1973-2012. 61
30280138 2018
100
Mid- to long-term clinical outcome of giant cell tumor of bone treated with calcium phosphate cement following thorough curettage and phenolization. 61
29315595 2018
101
Response evaluation of giant-cell tumor of bone treated by denosumab: Histogram and texture analysis of CT images. 61
29429890 2018
102
Giant cell tumor of the small bones of the foot. 61
30270796 2018
103
Osteoscopic Surgery of Giant Cell Tumor of Bone for Preservation of Proximal Fibula. 61
29715130 2018
104
Giant Cell Tumor of the Lateral Skull Base: Diagnostic and Management Options. 61
29845001 2018
105
Pathologic conditions of hard tissue: role of osteoclasts in osteolytic lesion. 61
29356963 2018
106
[Benign and malignant giant-cell rich lesions of bone: Pathological diagnosis with special emphasis on recent immunohistochemistry and molecular techniques]. 61
29580573 2018
107
[New aspects on giant cell tumor of bone]. 61
29110035 2018
108
Therapeutic benefits of neoadjuvant and post-operative denosumab on sacral giant cell tumor: a retrospective cohort study of 30 cases. 61
29745092 2018
109
Denosumab May Increase the Risk of Local Recurrence in Patients with Giant-Cell Tumor of Bone Treated with Curettage. 61
29557866 2018
110
Retrospective investigation of "paint brush borders" sign in association with local recurrence of giant cell tumor of bone after intralesional curettage. 61
29255669 2018
111
[Treatment progress on giant cell tumors of bone]. 61
29600686 2018
112
Magnetic resonance feature of "paintbrush borders" sign as a novel way to predict recurrence of giant cell tumor of bone after curettage: a pilot study. 61
29239274 2018
113
Osteonecrosis of the Jaw and Rebound Hypercalcemia in Young People Treated With Denosumab for Giant Cell Tumor of Bone. 61
29211870 2018
114
Expression of H3.3 G34W Distinguishes Giant Cell Tumor of Bone From Its Major Giant Cell-containing Bone and Soft Tissue Mimics, in Particular Aneurysmal Bone Cyst and Giant Cell Tumor of Soft Tissue. 61
29489506 2018
115
Giant Cell Tumor of Bone in Patients 55 Years and Older: A Study of 34 Patients. 61
29425276 2018
116
ALCAM+ stromal cells: role in giant cell tumor of bone progression. 61
29463803 2018
117
Safety and efficacy of denosumab in the treatment of pulmonary metastatic giant cell tumor of bone. 61
30013396 2018
118
STAT1, IGF1, RAC1, and MDM2 Are Associated with Recurrence of Giant Cell Tumor of Bone. 61
29651441 2018
119
Stromal Cell-Derived CCL20 Promotes Tumor Progression and Osteolysis in Giant Cell Tumor of Bone. 61
30537747 2018
120
Wide Resection and Iliac Crest Arthrodesis for Multiply Recurrent Giant Cell Tumor of First Metatarsal. 61
30631621 2018
121
Left orbital roof giant cell tumor of bone: A case report. 61
30034918 2018
122
Locally Aggressive Connective Tissue Tumors. 61
29220303 2018
123
Detection of H3F3A p.G35W and p.G35R in giant cell tumor of bone by Allele Specific Locked Nucleic Acid quantitative PCR (ASLNAqPCR). 61
29254795 2018
124
Probing the Function of Oncohistones Using Mutant Transgenes and Knock-In Mutations. 61
30073537 2018
125
High-activity chitosan/nano hydroxyapatite/zoledronic acid scaffolds for simultaneous tumor inhibition, bone repair and infection eradication. 61
29025652 2018
126
Development and validation of a prognostic index to predict pulmonary metastasis of giant cell tumor of bone. 61
29296223 2017
127
Malignant bone tumors (other than Ewing's): clinical practice guidelines for diagnosis, treatment and follow-up by Spanish Group for Research on Sarcomas (GEIS). 61
29038849 2017
128
Surveillance for lung metastasis from giant cell tumor of bone. 61
28650536 2017
129
Soft tissue recurrence of giant cell tumor of the bone: Prevalence and radiographic features. 61
29018768 2017
130
Multicentric giant cell tumor of bone: Case series of 4 patients. 61
28869118 2017
131
MicroRNA-30c suppressed giant-cell tumor of bone cell metastasis and growth via targeting HOXA1. 61
29164581 2017
132
Development of high-grade osteosarcoma in a patient with recurrent giant cell tumor of the ischium while receiving treatment with denosumab. 61
29048579 2017
133
Transformation of Benign Giant Cell Tumor of Bone Into Epithelioid Angiosarcoma. 61
29309463 2017
134
MiR-127 and miR-376a act as tumor suppressors by in vivo targeting of COA1 and PDIA6 in giant cell tumor of bone. 61
28866093 2017
135
TGF-β induced PAR-1 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone. 61
28670703 2017
136
Histone 3.3 mutations in giant cell tumor and giant cell-rich sarcomas of bone. 61
28899740 2017
137
Diagnostic value of histone 3 mutations in osteoclast-rich bone tumors. 61
28882701 2017
138
First report of stereotactic body radiotherapy for large-volume spinal tumors. 61
31149491 2017
139
Highly recurrent H3F3A mutations with additional epigenetic regulator alterations in giant cell tumor of bone. 61
28545165 2017
140
Giant-cell tumor of bone with pathological evidence of blood vessel invasion. 61
28633039 2017
141
An Active Giant Cell Tumor of the Patella: A Case Report. 61
29142790 2017
142
The distinct clinical features of giant cell tumor of bone in pagetic and non-pagetic patients are associated with genetic, biochemical and histological differences. 61
28968976 2017
143
H3F3A (Histone 3.3) G34W Immunohistochemistry: A Reliable Marker Defining Benign and Malignant Giant Cell Tumor of Bone. 61
28505000 2017
144
[Effectiveness of unicompartment allografts replacement for bone tumor around the knee]. 61
29806423 2017
145
TGF-β2-induced ANGPTL4 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone. 61
28903395 2017
146
TRAIL-R1 as a novel surface marker for circulating giant cell tumor of bone. 61
28881598 2017
147
Overexpression of zinc finger protein 687 enhances tumorigenic capability and promotes recurrence of hepatocellular carcinoma. 61
28737756 2017
148
Giant cell tumor of bone: imaging and histology changes after denosumab treatment : Comment on: von Borstel D, Taguibao RA, Strle NA, Burns JE. Giant cell tumor of the bone: Aggressive case initially treated with denosumab and intralesional surgery. Skeletal Radiol 2017;46:571-578. 61
28389819 2017
149
Pulmonary metastasis from giant cell tumor of bone: clinical outcome prior to the introduction of molecular target therapy. 61
28334868 2017
150
Freezing Nitrogen Ethanol Composite May be a Viable Approach for Cryotherapy of Human Giant Cell Tumor of Bone. 61
28197783 2017
151
CORR Insights®: Freezing Nitrogen Ethanol Composite May be a Viable Approach for Cryotherapy of Human Giant Cell Tumor of Bone. 61
28243975 2017
152
Genome-Wide Transcriptome Profiling of the Neoplastic Giant Cell Tumor of Bone Stromal Cells by RNA Sequencing. 61
27862217 2017
153
Clinical characteristics and risk factors analysis of lung metastasis of benign giant cell tumor of bone. 61
28443231 2017
154
Giant cell tumor of the thoracic spine completely removed by total spondylectomy after neoadjuvant denosumab therapy. 61
28396950 2017
155
Denosumab-treated giant cell tumor of bone. Its histologic spectrum and potential diagnostic pitfalls. 61
28235628 2017
156
Non-Small Cell Carcinoma of the Lung With Osteoclast-Like Giant Cells. 61
27899694 2017
157
Anchored multiplex PCR for targeted next-generation sequencing reveals recurrent and novel USP6 fusions and upregulation of USP6 expression in aneurysmal bone cyst. 61
27910166 2017
158
Epidemiological characteristics of primary spinal osseous tumors in Eastern China. 61
28376922 2017
159
The Role of Denosumab in the Modern Treatment of Giant Cell Tumor of Bone. 61
28441213 2017
160
Osseous Myopericytoma Simulating a Giant Cell Tumor of Bone: A Case Report. 61
29244665 2017
161
Denosumab in patients with giant-cell tumor of bone in Norway: results from a nationwide cohort. 61
28105885 2017
162
Denosumab treatment for progressive skull base giant cell tumor of bone in a 14 year old female - a case report and literature review. 61
28356124 2017
163
Microsurgical reconstruction in limb salvage due to a giant cell tumor of the distal radius. Case report. 61
28840677 2017
164
Successful treatment with denosumab in a patient with sacral giant cell tumor of bone refractory to combination therapy with arterial embolization and zoledronic acid: A case report. 61
28451403 2017
165
[Application of debridement and bone autografting combined with proximal femoral anatomical plates for benign tumor in proximal femur]. 61
29350012 2017
166
NCCN Guidelines Insights: Bone Cancer, Version 2.2017. 61
28188186 2017
167
[Updates and interpretations of 2017 NCCN guidelines for bone cancer]. 61
28056253 2017
168
Low-grade central osteosarcoma in proximal humerus: a rare entity. 61
29123414 2017
169
Clinicopathological Features of a Series of 27 Cases of Post-Denosumab Treated Giant Cell Tumors of Bones: A Single Institutional Experience at a Tertiary Cancer Referral Centre, India. 61
27722984 2017
170
MicroRNA-16-5p Inhibits Osteoclastogenesis in Giant Cell Tumor of Bone. 61
28589137 2017
171
Denosumab Therapy for Giant Cell Tumor of Bone Pulmonary Metastasis. 61
28573059 2017
172
Giant cell tumor of bone revisited. 61
28905737 2017
173
Giant Cell Tumor of Bone and Other Giant Cell-Rich Lesions. 61
28750392 2017
174
A Patient-Matched Entire First Metacarpal Prosthesis in Treatment of Giant Cell Tumor of Bone. 61
28698814 2017
175
Clinical and pathological results of denosumab treatment for giant cell tumors of bone: Prospective study of 14 cases. 61
27784623 2017
176
Two-stage surgery on pregnant woman with a giant cell tumor of bone who refused blood transfusion: A case report. 61
26740439 2017
177
Multiple giant cell tumors of bone arising from multiple fatty tumors. 61
27771752 2017
178
Reconstruction with β-Tricalcium Phosphate for Giant Cell Tumor of Bone around the Knee. 61
27018512 2017
179
Differential expression of filamin B splice variants in giant cell tumor cells. 61
27779699 2016
180
Giant Cell Tumor of Long Bones Outcomes of Treatment Corelating with Histopathological Grade. 61
28828045 2016
181
Denosumab treatment of inoperable or locally advanced giant cell tumor of bone. 61
28101196 2016
182
[Ilizarov TECHNIQUE FOR TREATMENT OF INFECTION AFTER LIMB SALVAGE OPERATION OF PRIMARY BONE TUMOR]. 61
29786332 2016
183
Risks and benefits of combining denosumab and surgery in giant cell tumor of bone-a case series. 61
27809843 2016
184
P63 expression as a biomarker discriminating giant cell tumor of bone from other giant cell-rich bone lesions. 61
27473669 2016
185
A case of thoracic giant cell tumor of bone and discussion of radiological features and current management practices. 61
27594954 2016
186
Case of a Missed Giant Cell Tumor of Bone: An Opportunity to Observe its Natural History Disease. 61
29782126 2016
187
Biological characteristics of a novel giant cell tumor cell line derived from spine. 61
26801673 2016
188
CD10 and CD138 can be expressed in giant cell tumor of bone: An immunohistochemical study. 61
27390668 2016
189
Reconstruction of the Midfoot Using a Free Vascularized Fibular Graft After En Bloc Excision for Giant Cell Tumor of the Tarsal Bones: A Case Report. 61
26213165 2016
190
Forty-three-Year Follow-up of Salvage Knee Reconstruction Using the Patella to Replace Lost Tibial Articular Surface: A Case Report. 61
29252640 2016
191
Multidisciplinary Approach to Management of Temporal Bone Giant Cell Tumor. 61
28078198 2016
192
Morphological Transformation of Giant-Cell Tumor of Bone After Treatment with Denosumab: A Case Report. 61
29252651 2016
193
Malignant Transformation of a Giant Cell Tumor of Bone Treated with Denosumab: A Case Report. 61
29252655 2016
194
Symplastic/pseudoanaplastic giant cell tumor of the bone. 61
27020452 2016
195
Giant Cell Tumor of Bone With Pseudosarcomatous Changes Leading to Premature Denosumab Therapy Interruption: A Case Report With Review of the Literature. 61
26842345 2016
196
Sex Differences in the Recurrence Rate and Risk Factors for Primary Giant Cell Tumors Around the Knee in China. 61
27321308 2016
197
Population-based study of giant cell tumor of bone in Sweden (1983-2011). 61
27060625 2016
198
A solitary pleural metastasis of benign giant cell tumor of bone. 61
27516881 2016
199
Expression of Matrix Metalloproteinase-9 and CD34 in Giant Cell Tumor of Bone. 61
27384731 2016
200
A thoracic spinal bone giant cell tumor in a skeletally immature girl. A case report and literature review. 61
26732064 2016
201
Bortezomib Inhibits Giant Cell Tumor of Bone through Induction of Cell Apoptosis and Inhibition of Osteoclast Recruitment, Giant Cell Formation, and Bone Resorption. 61
26861247 2016
202
Clinical and Radiographic Results of Reconstruction with Fibular Autograft for Distal Radius Giant Cell Tumor. 61
27384728 2016
203
Rapidly growing giant cell tumor of bone in a skeletally immature girl. 61
26585568 2016
204
Giant cell tumor of bone arising in long bones possibly originates from the metaphyseal region. 61
27073530 2016
205
Histopathological, immunohistochemical, and image analytic parameters characterizing the stromal component in primary and recurrent giant cell tumor of bone. 61
27182148 2016
206
Surgery methods and soft tissue extension are the potential risk factors of local recurrence in giant cell tumor of bone. 61
27094617 2016
207
Secondary malignant giant cell tumor of bone due to malignant transformation 40 years after surgery without radiation therapy, presenting as fever of unknown origin: a case report. 61
26951080 2016
208
Pseudosarcomatous Spindle Cell Proliferation With Osteoid Matrix Mimicking Osteosarcoma: A Distinct Histologic Phenotype in Giant Cell Tumor of Bone Following Denosumab Therapy. 61
25789537 2016
209
Chemotherapy for Bone Sarcoma in Adults. 61
26962160 2016
210
Differentiating giant cell tumor of bone from patellofemoral syndrome: a case study. 61
27069267 2016
211
ZNF687 Mutations in Severe Paget Disease of Bone Associated with Giant Cell Tumor. 61
26849110 2016
212
Restoration of miR-127-3p and miR-376a-3p counteracts the neoplastic phenotype of giant cell tumor of bone derived stromal cells by targeting COA1, GLE1 and PDIA6. 61
26655997 2016
213
Reconstruction of an Entire Thumb Metacarpal: A Case Report. 61
27014539 2016
214
Use of warm Ringer's lactate solution in the management of locally advanced giant cell tumor of bone. 61
26123312 2016
215
Percutaneous CT-Guided Cryoablation as an Alternative Treatment for an Extensive Pelvic Bone Giant Cell Tumor. 61
26126580 2016
216
Current status and unanswered questions on the use of Denosumab in giant cell tumor of bone. 61
27651889 2016
217
Giant Cell Tumor of Bone: Documented Progression over 4 Years from Its Origin at the Metaphysis to the Articular Surface. 61
27630783 2016
218
Inhibitory effect of bone morphogenetic protein-2 on the proliferation of giant cell tumor of bone stromal cells in vitro. 61
26889259 2016
219
The interdisciplinary approach of an aggressive giant cell tumor of bone complicated with a fracture of the distal femur. 61
27516036 2016
220
What role for radiobiphosphonates bone scintigraphy in the monitoring of an unusual bone giant cell tumor: a case report and literature review. 61
27186440 2016
221
Significance of β-catenin expression for the incidence of pathological fractures in giant cell tumors of bone. 61
28547961 2016
222
Receptor-Activator of Nuclear KappaB Ligand Expression as a New Therapeutic Target in Primary Bone Tumors. 61
27163152 2016
223
Denosumab-treated Giant Cell Tumor of Bone Exhibits Morphologic Overlap With Malignant Giant Cell Tumor of Bone. 61
26414220 2016
224
Severe hypercalcemia following denosumab treatment in a juvenile patient. 61
26056018 2016
225
Giant Cell Tumor within the Proximal Tibia after ACL Reconstruction. 61
26981302 2016
226
Giant Cell Tumor of Bone - An Overview. 61
26894211 2016
227
Salvage of the proximal femur following pathological fractures involving benign bone tumors. 61
26482583 2015
228
Rank ligand as a target in musculoskeletal neoplasms. 61
26452557 2015
229
Tibial stress reaction presenting as bilateral shin pain in a man taking denosumab for giant cell tumor of the bone. 61
26117225 2015
230
Prognostic value of p53 protein expression in giant cell tumor of bone. 61
27003771 2015
231
A mouse model of luciferase-transfected stromal cells of giant cell tumor of bone. 61
26327464 2015
232
Novel Clonal der(9)t(5;9)(q31;q34) Cytogenetic Translocation in a Giant Cell Tumor of Bone. 61
26551341 2015
233
Mutation Analysis of H3F3A and H3F3B as a Diagnostic Tool for Giant Cell Tumor of Bone and Chondroblastoma. 61
26457357 2015
234
Incidence Trends in the Diagnosis of Giant Cell Tumor of Bone in Sweden Since 1958. 61
26537163 2015
235
Objective tumor response to denosumab in patients with giant cell tumor of bone: a multicenter phase II trial. 61
26205395 2015
236
Giant Cell Tumor of Bone in Skeletally Immature Patients - A Clinical Perspective. 61
27299101 2015
237
MicroRNA-210 is upregulated by hypoxia-inducible factor-1α in the stromal cells of giant cell tumors of bone. 61
26239498 2015
238
Benign chondroblastoma on fine-needle aspiration smears: A seven-case experience and review of the literature. 61
25914148 2015
239
A High-grade Sarcoma Arising in a Patient With Recurrent Benign Giant Cell Tumor of the Proximal Tibia While Receiving Treatment With Denosumab. 61
25758379 2015
240
Surgical downstaging in an open-label phase II trial of denosumab in patients with giant cell tumor of bone. 61
26033180 2015
241
5-Fluoruracil blocked giant cell tumor progression by suppressing osteoclastogenesis through NF-kappaB signals and blocking angiogenesis. 61
25956534 2015
242
RANK and RANK ligand expression in primary human osteosarcoma. 61
27556008 2015
243
Epigenetic regulation of embryonic stem cell marker miR302C in human chondrosarcoma as determinant of antiproliferative activity of proline-rich polypeptide 1. 61
26094604 2015
244
MicroRNA-106b inhibits osteoclastogenesis and osteolysis by targeting RANKL in giant cell tumor of bone. 61
26053181 2015
245
Denosumab, a Potential Alternative to the Surgical Treatment of Distal Radius Giant Cell Tumor of Bone: Case Report. 61
25935517 2015
246
Prognostic role of nuclear factor/IB and bone remodeling proteins in metastatic giant cell tumor of bone: A retrospective study. 61
25764026 2015
247
Expression of IMP3 and IGF2 in giant cell tumor of spine is associated with tumor recurrence and angiogenesis. 61
25740666 2015
248
Endobronchial metastasis in benign giant cell tumor of bone in a 25-year male -Second case report with literature review. 61
26180400 2015
249
MiR-125b inhibits stromal cell proliferation in giant cell tumor of bone by targeting parathyroid hormone 1 receptor. 61
26351562 2015
250
Sternum bone giant cell tumor resection and chest wall reconstruction after the excision of breast cancer. 61
26458679 2015
251
Giant cell tumor of the capitate: an unusual case with 10 years follow-up. 61
27163074 2015
252
Giant cell tumor of soft tissue: a case report with emphasis on MR imaging. 61
25833278 2015
253
Primary leiomyosarcoma of the breast with prominent osteoclastic giant cells: A case expressing receptor activator of NF-κB ligand (RANKL). 61
26150133 2015
254
[Efficacy of endoscopic nasal lateral wall dissection approach in the treatment of maxillary sinus diseases]. 61
26513994 2015
255
Critical hypercalcemia following discontinuation of denosumab therapy for metastatic giant cell tumor of bone. 61
25556556 2015
256
[Expression of S100A8 and A100A9 in giant cell tumor of bone and its relation with CT and MR imaging findings]. 61
26350015 2015
257
Effect of denosumab on recurrent giant cell reparative granuloma of the lumbar spine. 61
25955096 2015
258
Expression of ezrin, CD44, and VEGF in giant cell tumor of bone and its significance. 61
25929323 2015
259
Inferior displacement of the lower belly of the lateral pterygoid muscle: a sign of temporomandibular joint lesions. 61
25700228 2015
260
A case of pulmonary metastasis of giant cell tumor of bone presenting as pulmonary arteriovenous malformation. 61
25839772 2015
261
Unusual Presentation of Giant Cell Tumor in Skeletally Immature Patient in Diaphysis of Ulna. 61
27299037 2015
262
Does total humeral endoprosthetic replacement provide reliable reconstruction with preservation of a useful extremity? 61
24801261 2015
263
Risk factors for pulmonary metastases from giant cell tumor of bone. 61
25740033 2015
264
Giant cell tumor of the lower end of tibia. Curettage and cement reconstruction. 61
25682416 2015
265
[Total en-bloc spondylectomy for recurrence spinal tumor]. 61
25908285 2015
266
RANK pathway in giant cell tumor of bone: pathogenesis and therapeutic aspects. 61
25618600 2015
267
Denosumab for the treatment of giant cell tumor of the bone. 61
26161925 2015
268
Local administration of zoledronic acid for giant cell tumor of bone. 61
25611416 2015
269
Two Cases of Sarcoma Arising in Giant Cell Tumor of Bone Treated with Denosumab. 61
26798348 2015
270
Epidemiological Aspects of Osteosarcoma, Giant Cell Tumor and Chondrosarcoma Musculoskeletal Tumors--Experience of the National Rehabilitation Institute, Mexico City. 61
26434858 2015
271
Association of Metastasis with Clinicopathological Data in Mexican Patients with Osteosarcoma, Giant Cell Tumor of Bone and Chondrosarcoma. 61
26625782 2015
272
Chemotherapy for bone sarcomas in adults: the MD anderson experience. 61
25993237 2015
273
Prognostic impact of reduced connexin43 expression and gap junction coupling of neoplastic stromal cells in giant cell tumor of bone. 61
25933380 2015
274
Denosumab: A bone antiresorptive drug. 61
25609868 2015
275
Serum Levels of NTx and TRACP5b in Giant Cell Tumor of Bone and its Clinical Implications. 61
26427154 2015
276
Squamous cell carcinoma of lung associated with osteoclast-like giant cells: report of a case. 61
26617934 2015
277
A recurrent giant cell tumor of bone treated with denosumab. 61
25918628 2015
278
Giant-cell tumor of bone: treatment options and role of denosumab. 61
26203221 2015
279
Differential Expression of ADAM23, CDKN2A (P16), MMP14 and VIM Associated with Giant Cell Tumor of Bone. 61
26078788 2015
280
Expressions and clinical significance of factors related to giant cell tumor of bone. 61
26885235 2015
281
Expression of CD147, PCNA, VEGF, MMPs and their clinical significance in the giant cell tumor of bones. 61
26339416 2015
282
Joint preserved reconstruction after curettage in giant cell tumor of bone arising in the distal radius: Case report. 61
26492357 2015
283
Successful Intravascular Correction of Intratumoral Pseudoaneurysm by Erosion of the Aorta in a Patient with Thoracic Giant Cell Tumor of Bone Responding to Denosumab. 61
26600960 2015
284
Factors Affecting the Recurrence of Giant Cell Tumor of Bone After Surgery: A Clinicopathological Study of 80 Cases from a Single Center. 61
26202356 2015
285
[GIANT CELL TUMOR OF BONE: RESULTS AND TREATMENT COMPLICATIONS]. 61
26285474 2014
286
Regional variation and challenges in estimating the incidence of giant cell tumor of bone. 61
25471915 2014
287
Management of central giant cell granuloma with subcutaneous denosumab therapy. 61
25262402 2014
288
Gene expression profiling of giant cell tumor of bone reveals downregulation of extracellular matrix components decorin and lumican associated with lung metastasis. 61
25304290 2014
289
Giant cell tumor of bone. 61
25378541 2014
290
Enrichment of c-Met+ tumorigenic stromal cells of giant cell tumor of bone and targeting by cabozantinib. 61
25321478 2014
291
Histological Regression of Giant Cell Tumor of Bone Following RANK Ligand Inhibition. 61
26425630 2014
292
Subretinal Bone Formation in a Patient with Giant Cell Tumor of the Sphenoid. 61
27175360 2014
293
MiR-30a inhibits osteolysis by targeting RunX2 in giant cell tumor of bone. 61
25264196 2014
294
Malignant giant cell tumor of the rib with lung metastasis in a man. 61
25276374 2014
295
Effects of denosumab on pain and analgesic use in giant cell tumor of bone: interim results from a phase II study. 61
24834795 2014
296
Chemical functionalization of bone implants with nanoparticle-stabilized chitosan and methotrexate for inhibiting both osteoclastoma formation and bacterial infection. 61
25177491 2014
297
Giant cell tumor of bone: current treatment options. 61
24788576 2014
298
Early evaluation of the therapeutic effect of denosumab on tartrate-resistant acid phosphatase 5b expression in a giant cell tumor of bone: a case report. 61
25193435 2014
299
A Translational Study of the Neoplastic Cells of Giant Cell Tumor of Bone Following Neoadjuvant Denosumab. 61
25100780 2014
300
Genetics of rare mesenchymal tumors: implications for targeted treatment in DFSP, ASPS, CCS, GCTB and PEComa. 61
24704529 2014
301
Targeting receptor-activator of nuclear kappaB ligand in aneurysmal bone cysts: verification of target and therapeutic response. 61
24726460 2014
302
Pulmonary metastasis of giant cell tumor of bones. 61
25139054 2014
303
The multidisciplinary management of giant cell tumor of bone. 61
24666240 2014
304
Giant cell tumor of bone involving the temporomandibular joint and temporal bone. 61
25006918 2014
305
Epigenetic silencing of genes and microRNAs within the imprinted Dlk1-Dio3 region at human chromosome 14.32 in giant cell tumor of bone. 61
25005035 2014
306
Giant cell tumor of bone presenting in the lumbar spine of a 35-year-old female: cytodiagnosis and other diagnostic considerations. 61
23637103 2014
307
Dedifferentiated giant-cell tumor of bone with an undifferentiated round cell mesenchymal component. 61
25276319 2014
308
Giant cell tumor of bone with secondary aneurysmal bone cyst-like change producing β-human chorionic gonadotropin. 61
24362936 2014
309
[Clinicopathologic differential diagnosis of giant cell-rich osteosarcoma and giant cell tumor of bone]. 61
25208987 2014
310
Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab. 61
24906559 2014
311
Isocitrate dehydrogenase mutation is frequently observed in giant cell tumor of bone. 61
24898068 2014
312
Giant cell tumor of bone in a patient with diagnosis of primary hyperparathyroidism: a challenge in differential diagnosis with brown tumor. 61
24270977 2014
313
The clinical approach toward giant cell tumor of bone. 61
24718514 2014
314
Fibrosarcoma development 15 years after curettage and bone grafting of giant cell tumor of bone. 61
24810832 2014
315
Percutaneous radiofrequency ablation for treatment of giant cell tumor of bone guided by real-time US fused with CT. 61
27277777 2014
316
Liquid nitrogen or phenolization for giant cell tumor of bone?: a comparative cohort study of various standard treatments at two tertiary referral centers. 61
24599207 2014
317
[Allogeneic bone transplantation for pelvic reconstruction of large skeletal defects after tumor resection]. 61
24844014 2014
318
Dedifferentiated chondrosarcoma mimicking a giant cell tumor. Is this low grade dedifferentiated chondrosarcoma? 61
24405942 2014
319
May bone cement be used to treat benign aggressive bone tumors of the feet with confidence? 61
24365067 2014
320
Giant cell tumor of bone. 61
24679193 2014
321
Giant cell tumor of bone in childhood: clinical aspects and novel therapeutic targets. 61
24114694 2014
322
Intracranial, intra-axial metastatic giant cell tumor of bone: case report and review of literature. 61
24438802 2014
323
Triple-phase dynamic MRI: a new clue to predict malignant transformation of giant cell tumor of bone. 61
24239410 2014
324
Giant cell tumor of distal phalanx in an adolescent with Goltz-Gorlin syndrome. 61
25804026 2014
325
Metachronous multicentric giant cell tumor of bone with retroperitoneal metastasis. 61
25043095 2014
326
[Clinical perspectives of the study of RANK/RANKL/OPG system components in primary and metastatic bone tumor]. 61
25552059 2014
327
[Multicentric giant cell tumor: clinical analysis of 9 cases]. 61
24534311 2013
328
Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone. 61
24162739 2013
329
Recurrent H3.3 alterations in childhood tumors. 61
24270444 2013
330
Inactivated autograft-prosthesis composite has a role for grade III giant cell tumor of bone around the knee. 61
24209887 2013
331
Postoperative irrigation with bisphosphonates may reduce the recurrence of giant cell tumor of bone. 61
23968573 2013
332
Denosumab: a new treatment option for giant cell tumor of bone. 61
24308016 2013
333
[Surgical treatment for long bone giant cell tumor of extremity with pathologic fracture]. 61
24136271 2013
334
Radiotherapy in the management of giant cell tumor of bone. 61
22781387 2013
335
[Factors related to biologic behavior in giant cell tumor of bone]. 61
24433729 2013
336
[Diagnosis and treatment of giant cell tumor of bone in skeletal immature patients]. 61
24330965 2013
337
Iatrogenic implantation of giant cell tumor at bone graft donor site and clinical recommendations to prevent "a rare avoidable complication". 61
23412188 2013
338
Subchondral bone grafting reduces degenerative change of knee joint in patients of giant cell tumor of bone. 61
23981611 2013
339
Pharmaceutical approval update. 61
24222975 2013
340
Contemporary adjuvant polymethyl methacrylate cementation optimally limits recurrence in primary giant cell tumor of bone patients compared to bone grafting: a systematic review and meta-analysis. 61
23866921 2013
341
Parathyroid hormone-related protein (PTHrP) modulates adhesion, migration and invasion in bone tumor cells. 61
23466453 2013
342
p53 mutations may be involved in malignant transformation of giant cell tumor of bone through interaction with GPX1. 61
23748877 2013
343
Modulation of osteoclastic migration by metabolism of 25OH-vitamin D3. 61
22989483 2013
344
Giant cell tumor of bone in a child with Goltz syndrome. 61
23530933 2013
345
Updates in the treatment of bone cancer. 61
23704242 2013
346
Myofibroblastic differentiation of stromal cells in giant cell tumor of bone: an immunohistochemical and ultrastructural study. 61
23650991 2013
347
MicroRNA expression profiles in metastatic and non-metastatic giant cell tumor of bone. 61
23172052 2013
348
Retroperitoneal mass: a diagnostic challenge. 61
24362615 2013
349
Expression of osteoprotegerin and osteoprotegerin ligand in giant cell tumor of bone and its clinical significance. 61
23599752 2013
350
Denosumab treatment of metastatic giant-cell tumor of bone in a 10-year-old girl. 61
23509309 2013
351
Sustained autocrine induction and impaired negative feedback of osteoclastogenesis in CD14(+) cells of giant cell tumor of bone. 61
23395086 2013
352
[Long-term effect of repeated selective arterial embolization and curettage on high-level sacral giant cell tumor of bone]. 61
23880008 2013
353
Giant cell tumor with pathologic fracture: should we curette or resect? 61
22926445 2013
354
Long-term outcome of giant cell tumor of bone involving sacroiliac joint treated with selective arterial embolization and curettage: a case report and literature review. 61
23497322 2013
355
p63 as a prognostic marker for giant cell tumor of bone. 61
23033898 2013
356
Benign looking giant cell component in dedifferentiated chondrosarcoma: benign or malignant? A case report. 61
22736299 2013
357
Giant cell tumor occurring in familial Paget's disease of bone: report of clinical characteristics and linkage analysis of a large pedigree. 61
22936311 2013
358
Giant cell tumor of bone. 61
23378375 2013
359
Use of a calcium sulfate-calcium phosphate synthetic bone graft composite in the surgical management of primary bone tumors. 61
23380017 2013
360
p63 regulates cell proliferation and cell cycle progression‑associated genes in stromal cells of giant cell tumor of the bone. 61
23229819 2013
361
Clinical outcomes of giant cell tumor of bone treated with bone cement filling and internal fixation, and oral bisphosphonates. 61
23420680 2013
362
Expressional Analysis of GFP-Tagged Cells in an In Vivo Mouse Model of Giant Cell Tumor of Bone. 61
23730372 2013
363
Smad3 is the key to transforming growth factor-β1-induced osteoclast differentiation in giant cell tumor of bone. 61
23690270 2013
364
Denosumab chemotherapy for recurrent giant-cell tumor of bone: a case report of neoadjuvant use enabling complete surgical resection. 61
23984138 2013
365
A rare location for a common bone tumor, meta-diaphyseal giant cell tumor of bone in an adult patient. 61
24179645 2013
366
[Clinical observation of surgical management for recurrent giant cell tumor of bone]. 61
23427489 2013
367
Targeting the giant cell tumor stromal cell: functional characterization and a novel therapeutic strategy. 61
23922683 2013
368
Rare presentation of giant cell tumor of bone in the lateral end of the clavicle. 61
23875059 2013
369
A Systematic Review and Meta-Analysis of En-Bloc vs Intralesional Resection for Giant Cell Tumor of Bone of the Distal Radius. 61
23730371 2013
370
Comparison of the anti-tumor effects of denosumab and zoledronic acid on the neoplastic stromal cells of giant cell tumor of bone. 61
24060052 2013
371
Primary hyperparathyroidism presenting as a giant cell tumor of the jaws. 61
23645306 2013
372
Multicentric giant cell tumor of bone: synchronous and metachronous presentation. 61
24106628 2013
373
[Skeletal disease in primary hyperparathyroidism: X-ray, CT and MR imaging founding]. 61
23578450 2013
374
Giant cell tumor of bone: review, mimics, and new developments in treatment. 61
23322837 2013
375
Giant cell tumor of bone: a basic science perspective. 61
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376
Multicentric Giant Cell Tumor of Bone and Paraganglioma: A Case Report. 61
29252328 2013
377
Giant cell tumor of uterus resembling osseous giant cell tumor: case report and review of literature. 61
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378
Stro-1(+) stromal cells have stem-like features in giant cell tumor of bone. 61
22605660 2012
379
Benign tumors of the spine. 61
23118137 2012
380
Overexpression of hexokinase-2 in giant cell tumor of bone is associated with false positive in bone tumor on FDG-PET/CT. 61
22825642 2012
381
Late malignant transformation of giant cell tumor of bone 41 years after primary surgery. 61
23027500 2012
382
Pulmonary metastases due to a giant-cell tumor of bone. 61
22791763 2012
383
Giant-cell tumor of bone, anti-RANKL therapy. 61
24363925 2012
384
Can p63 serve as a biomarker for giant cell tumor of bone? A Moroccan experience. 61
23016917 2012
385
The outcomes of treatment of giant cell tumor of bone around the knee. 61
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386
In vitro effects of thermoablation on apoptosis of giant cell tumor of bone: a preliminary report. 61
23326996 2012
387
Pre-operative selective arterial embolization as a neoadjuvant therapy for proximal humerus giant cell tumor of bone: radiological and histological evaluation. 61
22689917 2012
388
Transcriptomic and proteomic analyses in bone tumor cells: Deciphering parathyroid hormone-related protein regulation of the cell cycle and apoptosis. 61
22508574 2012
389
Soft tissue extension increases the risk of local recurrence after curettage with adjuvants for giant-cell tumor of the long bones. 61
22880716 2012
390
Denosumab induces tumor reduction and bone formation in patients with giant-cell tumor of bone. 61
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391
Giant cell tumor of bone mimicking metastatic renal cell carcinoma: a case report. 61
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[Giant-cell lesions of bone and their differential diagnosis]. 61
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393
RANKL, denosumab, and giant cell tumor of bone. 61
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394
Giant cell tumor of the distal ulna: a case report. 61
22657940 2012
395
PTHrP increases RANKL expression by stromal cells from giant cell tumor of bone. 61
22102368 2012
396
Giant cell tumor of bonelike lesion in a Trp53 mutant mouse. 61
22328409 2012
397
Modern interpretation of giant cell tumor of bone: predominantly osteoclastogenic stromal tumor. 61
22662295 2012
398
Management of giant cell tumor of bone: computerized tomography based selection strategy and approaching the lesion through the site of cortical break. 61
22615151 2012
399
T cells stimulate catabolic gene expression by the stromal cells from giant cell tumor of bone. 61
22386994 2012
400
Histological and clinical characteristics of malignant giant cell tumor of bone. 61
22350004 2012
401
CD138 (syndecan-1) expression in bone-forming tumors. 61
22338054 2012
402
Bone Cytology: A Realistic Approach for Clinical Use. 61
26837916 2012
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Giant cell tumor of bone: are we stratifying results appropriately? 61
22125240 2012
404
Giant Cell Tumor of Bone. 61
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405
Cytomorphology of giant cell tumor of bone in pleural fluid. 61
23227101 2012
406
Rapamycin inhibits osteoclast formation in giant cell tumor of bone through the C/EBPβ - MafB axis. 61
22071989 2012
407
Tartrate-Resistant Acid Phosphatase 5b is a Useful Serum Marker for Diagnosis and Recurrence Detection of Giant Cell Tumor of Bone. 61
22962569 2012
408
Giant cell tumors of the axial skeleton. 61
22448122 2012
409
Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation. 61
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410
Aggressive giant cell tumor of the anterior arc of the rib. 61
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411
[Limb preservation surgery combined with perioperative rehabilitation for the treatment of 7 patients with stage II to III giant cell tumor of bone in the proximal humerus]. 61
22276517 2011
412
Primary hyperparathyroidism diagnosed after surgical ablation of a costal mass mistaken for giant-cell bone tumor: a case report. 61
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413
Central giant cell lesion. 61
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414
Osteoclast-rich undifferentiated carcinoma of the urinary bladder: an immunohistochemical study. 61
22019007 2011
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A case of de novo secondary malignant giant-cell tumor of bone with loss of heterozygosity of p53 gene that transformed within a short-term follow-up. 61
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[Computer-aided precise resection of pelvic tumor and function reconstruction]. 61
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Denosumab: benefits of RANK ligand inhibition in cancer patients. 61
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The role of TWIST as a regulator in giant cell tumor of bone. 61
21503964 2011
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Locally administered zoledronic Acid therapy for giant cell tumor of bone. 61
21717996 2011
420
Giant cell tumor of soft tissue of hand: simple but rare diagnosis, which is often missed. 61
24765315 2011
421
A short-term in vivo model for giant cell tumor of bone. 61
21668953 2011
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Siglec-15, a member of the sialic acid-binding lectin, is a novel regulator for osteoclast differentiation. 61
21586272 2011
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p63 expression in giant cell-containing lesions of bone and soft tissue. 61
21631272 2011
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A case of secondary malignant giant-cell tumor of bone with p53 mutation after long-term follow-up. 61
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Giant cell tumor of bone with lymph node metastases: a rare presentation. 61
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A case of giant cell tumor of the hipbone invading the bladder. 61
21623573 2011
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Recurrent giant cell tumor of long bones: analysis of surgical management. 61
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Differentially expressed genes in giant cell tumor of bone. 61
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Local recurrences after curettage and cementing in long bone giant cell tumor. 61
21430873 2011
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Pamidronate, farnesyl transferase, and geranylgeranyl transferase-I inhibitors affects cell proliferation, apoptosis, and OPG/RANKL mRNA expression in stromal cells of giant cell tumor of bone. 61
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Effect of water-soluble P-chitosan and S-chitosan on human primary osteoblasts and giant cell tumor of bone stromal cells. 61
21205994 2011
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CCND1 and MET genomic amplification during malignant transformation of a giant cell tumor of bone. 61
21098327 2011
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Giant cell tumor of bone: risk factors for recurrence. 61
20706812 2011
434
Therapeutic targeting of osteoclast function and pathways. 61
21204734 2011
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Erratum: Gene transfection in primary stem-like cells of giant cell tumor of bone. 61
24198527 2011
436
Best cases from the AFIP: Necrotic giant cell tumor of bone manifesting with pathologic fracture. 61
21257935 2011
437
Identification of potential biomarkers for giant cell tumor of bone using comparative proteomics analysis. 61
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AP-1 as a Regulator of MMP-13 in the Stromal Cell of Giant Cell Tumor of Bone. 61
21461405 2011
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Intramedullary spinal cord metastasis following spontaneous malignant transformation from giant cell tumor of bone 16 years after pulmonary metastasis. 61
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PTHrP induces autocrine/paracrine proliferation of bone tumor cells through inhibition of apoptosis. 61
21625386 2011
441
Interferon alfa-2b for recurrent and metastatic giant cell tumor of the spine: report of two cases. 61
21030898 2010
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A case of recurrent giant cell tumor of bone with malignant transformation and benign pulmonary metastases. 61
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Giant cell tumor of the distal femur associated with complete tumor necrosis. 61
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Functional results after giant cell tumor operation near knee joint and the cement radiolucent zone as indicator of recurrence. 61
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Evidence for the role of matrix metalloproteinase-13 in bone resorption by giant cell tumor of bone. 61
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[Tumor-segmental resection of hand-foot-giant cell tumor of bone and autologous iliac bone graft reconstruction]. 61
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Long-term outcome of giant cell tumors of bone around the knee treated by en bloc resection of tumor and reconstruction with prosthesis. 61
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[Giant cell tumor of temporal bone and mandibular condyle: a case report]. 61
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[Giant cell tumor of bone in a patient with HIV infection]. 61
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Primary giant cell tumor of soft tissue: fluid-fluid levels at MRI (2010:3b). 61
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CCAAT/enhancer binding protein beta is up-regulated in giant cell tumor of bone and regulates RANKL expression. 61
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Giant cell tumor in a case of Paget's disease of bone: an aggressive benign tumor exhibiting a quick response to an innovative therapeutic agent. 61
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P53 expression as a prognostic marker in giant cell tumor of bone: a pilot study. 61
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Metacarpal giant-cell tumor of bone in children. 61
20375665 2010
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Giant Cell Tumor (tumor gigantocellularis, osteoclastoma) - epidemiology, diagnosis, treatment. 61
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Comparative proteomics analysis of human osteosarcomas and benign tumor of bone. 61
20362224 2010
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Application of mixed bone graft (autograft+allograft) in the management of giant cell tumor of bone. 61
20395916 2010
458
Metastatic giant cell tumor of bone: are there associated factors and best treatment modalities? 61
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Primary malignant giant-cell tumor of bone has high survival rate. 61
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460
Polypoid giant cell tumor of the skin. 61
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Could MTA be a novel medicine on the recurrence therapy for GCTB? 61
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Fine needle aspiration cytology of benign fibrous histiocytoma of bone: a case report. 61
20306998 2010
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High-Speed Burring with and without the Use of Surgical Adjuvants in the Intralesional Management of Giant Cell Tumor of Bone: A Systematic Review and Meta-Analysis. 61
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Giant-cell tumor of the distal ulna treated by wide resection and ulnar support reconstruction: a case report. 61
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[Multifocal giant cell tumor of bone: a care report]. 61
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Gene transfection in primary stem-like cells of giant cell tumor of bone. 61
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Cytotoxic effect of zoledronic acid-loaded bone cement on giant cell tumor, multiple myeloma, and renal cell carcinoma cell lines. 61
20048108 2010
468
Giant cell tumor-like lesion of the urinary bladder: a report of two cases and literature review; giant cell tumor or undifferentiated carcinoma? 61
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Giant cell reparative granuloma of the axis. 61
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[MMP- and FAP-mediated non-inflammation-related destruction of cartilage and bone in rheumatoid arthritis]. 61
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471
Primary giant cell tumor of soft tissue of the groin - a case of 46 years duration. 61
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Treatment and differential diagnosis of aneurysmal bone cyst based on our own experience. 61
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[CT guided radio frequency ablation as a treatment of pelvis tumor]. 61
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Upregulation of MMP-13 via Runx2 in the stromal cell of Giant Cell Tumor of bone. 61
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Treatment of giant cell tumor of long bones: clinical outcome and reconstructive strategy for lower and upper limbs. 61
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Cytogenetic analysis of 101 giant cell tumors of bone: nonrandom patterns of telomeric associations and other structural aberrations. 61
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477
Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas. 61
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478
Expression of bone morphogenetic proteins in giant cell tumor of bone. 61
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479
Genomic instability in giant cell tumor of bone. A study of 52 cases using DNA ploidy, relocalization FISH, and array-CGH analysis. 61
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[Applications of external fixation for management of complications associated with musculoskeletal tumors and related surgery]. 61
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[Giant cell tumor of bone and malignancies in giant cell tumor: a clinicopathologic analysis]. 61
19575873 2009
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Chondroblastic osteosarcoma of the cuboid: a literature review and report of a rare case. 61
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Endoscopic endonasal surgery for biopsy of cavernous sinus lesions. 61
19452412 2009
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Epidemiology of bone tumors in Mexico City: retrospective clinicopathologic study of 566 patients at a referral institution. 61
19118777 2009
485
Curettage of benign bone tumors without grafts gives sufficient bone strength. 61
19234882 2009
486
Fine-needle aspiration of brown tumor of bone: cytologic features with radiologic and histologic correlation. 61
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487
Surgical treatment of multifocal giant cell tumor of carpal bones with preservation of wrist function: case report. 61
19135808 2009
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Telomeric associations correlate with telomere length reduction and clonal chromosome aberrations in giant cell tumor of bone. 61
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[Survivin and COX-2 expressions in giant cell tumor of bone and their relation to the prognosis]. 61
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Soft-tissue recurrence of giant cell tumor of bone associated with pulmonary metastases. 61
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Giant cell tumor of bone in elderly patients: a study of ten patients. 61
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492
Immunohistochemical analyses of beta-catenin and cyclin D1 expression in giant cell tumor of bone (GCTB): a possible role of Wnt pathway in GCTB tumorigenesis. 61
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Matrix Metalloproteinase Activity in the Stromal Cell of Giant Cell Tumor of Bone. 61
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CD33+ CD14- phenotype is characteristic of multinuclear osteoclast-like cells in giant cell tumor of bone. 61
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[Histologic study of local infiltration of spinal bone giant cell tumor and chordoma]. 61
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496
Knee reconstruction with preservation of the meniscus in tibial giant cell tumor. 61
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[Total elbow arthroplasty after resection of tumors at the elbow]. 61
19094737 2008
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[Differential diagnosis of giant cell-rich lesions of bone]. 61
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[Repairing bone defects of benign bone neoplasm by grafting of bioactive glass combined with autologous bone marrow]. 61
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[Osteomalacia and giant cell tumor: a rare case]. 61
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Histogenetic characterization of giant cell tumor of bone. 61
18543051 2008
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Giant cell tumor of bone: treatment and outcome of 214 cases. 61
18322700 2008
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Clinicopathologic profile of 470 giant cell tumors of bone from a cancer hospital in western India. 61
18620989 2008
504
Giant cell tumor of bone with secondary aneurysmal bone cyst. 61
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505
Primary giant cell tumor of soft tissue in the finger. 61
18713588 2008
506
Local recurrence of giant cell tumor of bone after intralesional treatment with and without adjuvant therapy. 61
18451399 2008
507
Distribution and prognostic significance of human telomerase reverse transcriptase (hTERT) expression in giant-cell tumor of bone. 61
18204433 2008
508
Giant cell tumor of bone express p63. 61
18311114 2008
509
Dedifferentiated parosteal osteosarcoma with giant cell tumor component. 61
18256826 2008
510
Carcinosarcomatous malignancy, osteosarcoma and squamous cell carcinoma, in giant cell tumor of the right distal femur. 61
18440162 2008
511
Giant cell tumor of bone: a neoplasm or a reactive condition? 61
18787633 2008
512
[Application of cryodestruction in the treatment of the bone giant cell tumor]. 61
18610858 2008
513
Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: a case-control study. 61
17962092 2008
514
Diagnostic and therapeutic problems of giant cell tumor in the proximal femur. 61
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515
Re-operation results in osteoarthritic change of knee joints in patients with giant cell tumor of bone. 61
17601737 2007
516
Telomerase activity in giant cell tumors of bone. 61
17653593 2007
517
Giant cell tumor of soft tissue arising in breast. 61
17870021 2007
518
Giant cell tumor of bone in children and adolescents. 61
17717462 2007
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Unstable translocation (8;22) in a case of giant cell reparative granuloma. 61
17693193 2007
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Novel karyotypes in giant cell-rich lesions of bone. 61
17527082 2007
521
SH3BP2 is rarely mutated in exon 9 in giant cell lesions outside cherubism. 61
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Properties of the stromal cell in giant cell tumor of bone. 61
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[Total spondylectomy and reconstruction for thoracolumbar spinal tumors with neurological deficit]. 61
17578278 2007
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[Endoprosthetic reconstruction after wide resection of primary bone tumor around the knee]. 61
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Diagnoses and clinical outcomes associated with surgically amputated feline digits submitted to multiple veterinary diagnostic laboratories. 61
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[Massive allograft replacement in management of bone tumors]. 61
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Imaging of giant cell tumor of bone. 61
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Giant cell tumor of bone: Multimodal approach. 61
21139762 2007
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Treatment of giant cell tumor of bone: Current concepts. 61
21139760 2007
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Giant cell tumor of bone: Is curettage the answer? 61
21139761 2007
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The value of recognizing suspect diagnoses in the triple diagnosis of giant cell tumor of bone. 61
21139759 2007
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[Malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report]. 61
17568357 2007
533
Primary malignant giant cell tumor of bone: a series of three rare cases. 61
17592717 2007
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[An analysis on follow-up of the treatment of complicated giant cell tumor of bone]. 61
17140074 2006
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[Case analysis on treatment and recurrence of giant cell tumor of bone]. 61
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[Vascularized fibular combined with iliac grafting to repair bone defect after tumor extensive resection for giant cell tumor of bone around knee]. 61
17140068 2006
537
20q11.1 amplification in giant-cell tumor of bone: Array CGH, FISH, and association with outcome. 61
16847944 2006
538
Multicentric giant cell tumor of bone. Clinicopathologic analysis of thirty cases. 61
16951117 2006
539
Hip joint remodeling in an adult following excision of a giant cell tumor involving the acetabulum: a case report and literature review. 61
16810549 2006
540
[Analysis of the factors affecting the recurrence of giant cell tumor of bone]. 61
16889722 2006
541
Similarities between giant cell tumor of bone, giant cell tumor of tendon sheath, and pigmented villonodular synovitis concerning ultrastructural cytochemical features of multinucleated giant cells and mononuclear stromal cells. 61
16825116 2006
542
Multicentric, synchronous giant-cell tumor of bone. 61
16598336 2006
543
Giant cell tumor of bone. 61
16462511 2006
544
Osteosarcoma arising from giant cell tumor of bone ten years after primary surgery: a case report and review of the literature. 61
16434839 2006
545
Giant cell tumor of bone. 61
16311110 2006
546
Diagnostic value of fine needle aspiration cytology in gouty tophi: a report of 7 cases. 61
16514850 2006
547
Ethanol as a local adjuvant for giant cell tumor of bone. 61
16789453 2006
548
Serum total acid phosphatase for monitoring the clinical course of giant cell tumors of bone--26 patients with 5 local recurrences. 61
16263611 2005
549
Phenotypic and molecular studies of giant-cell tumors of bone and soft tissue. 61
16153456 2005
550
Impact severity of local recurrence in giant cell tumor of bone. 61
16131879 2005
551
Cytological properties of stromal cells derived from giant cell tumor of bone (GCTSC) which can induce osteoclast formation of human blood monocytes without cell to cell contact. 61
16024207 2005
552
[Allograft replacement in management of giant cell tumor of bone: a report of 77 cases]. 61
16194332 2005
553
Molecular profiling of giant cell tumor of bone and the osteoclastic localization of ligand for receptor activator of nuclear factor kappaB. 61
15972958 2005
554
Evidence for telomeric fusions as a mechanism for recurring structural aberrations of chromosome 11 in giant cell tumor of bone. 61
15860354 2005
555
Recurrent giant cell tumor of bone with simultaneous regional lymph node and pulmonary metastases. 61
15365782 2005
556
Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone. 61
15607894 2005
557
Differential gene expression in stromal cells of human giant cell tumor of bone. 61
15449052 2004
558
Immunohistochemical evaluation of microphthalmia-associated transcription factor expression in giant cell lesions. 61
15205688 2004
559
[Extended transsphenoidal approach to giant tumors in sellar and clival area]. 61
15569427 2004
560
[Central giant cell granuloma and osteitis fibrosa cystica of hyperparathyroidism. A challenge in differential diagnosis of patients with osteolytic jawbone lesions and a history of cancer]. 61
15480872 2004
561
Bisphosphonates may reduce recurrence in giant cell tumor by inducing apoptosis. 61
15346059 2004
562
Surgical management for giant cell tumor of bones. 61
15959547 2004
563
Soft tissue giant cell tumor of low malignant potential. 61
15595466 2004
564
Aneurysmal bone cyst and giant cell tumor of bone of the hand and distal radius. 61
15275686 2004
565
Cryotherapy of musculoskeletal tumors--from basic science to clinical results. 61
15270588 2004
566
Cathepsin K is the principal protease in giant cell tumor of bone. 61
15277232 2004
567
Results of giant cell tumor of bone treated with intralesional excision. 61
15241169 2004
568
Osteoclast-type giant cell neoplasm of salivary gland. A microdissection-based comparative genotyping assay and literature review: extraskeletal "giant cell tumor of bone" or osteoclast-type giant cell "carcinoma"? 61
15223968 2004
569
Bisphosphonates induce apoptosis of stromal tumor cells in giant cell tumor of bone. 61
15037971 2004
570
Anaplastic thyroid carcinoma with osteoclast-like giant cells. 61
15645990 2004
571
Free fibula long bone reconstruction in orthopedic oncology: a surgical algorithm for reconstructive options. 61
15253188 2004
572
Thapsigargin potentiates TRAIL-induced apoptosis in giant cell tumor of bone. 61
15193543 2004
573
Giant cell tumor of rib masquerading as thymoma: a diagnostic pitfall in needle core biopsy of the mediastinum. 61
15043459 2004
574
Central giant cell granuloma of the jaws: assessment of cell cycle proteins. 61
15128059 2004
575
[Giant cell tumor of bone with rapid malignant course]. 61
15007559 2004
576
Proteases and interleukin-6 gene analysis in 92 giant cell tumors of bone. 61
14998856 2004
577
Decreased expression of transforming growth factor-beta II receptor is associated with that of p27KIP1 in giant cell tumor of bone: a possible link between transforming growth factor-beta and cell cycle-related protein. 61
14745726 2004
578
Giant cell tumor of tendon sheath simulating giant cell tumor of bone: report of a case. 61
15281411 2004
579
Mimics on radiography of giant cell tumor of bone. 61
14627578 2003
580
Giant cell tumor of bone with pulmonary metastases. 61
14515387 2003
581
[Giant cell tumor of bone. An evaluation of 87 patients]. 61
14679436 2003
582
Metatarsal giant cell tumors and giant cell reparative granuloma are similar entities. 61
14646771 2003
583
Cytochemical and ultrastructural changes in the osteoclast-like giant cells of giant cell tumor of bone following bisphosphonate administration. 61
14660277 2003
584
Primary giant cell tumor of soft tissue. Report of a case with fine needle aspiration cytologic and histologic findings. 61
14674090 2003
585
Cytogenetic analysis of the mononuclear cell component of giant cell tumors of bone. 61
14553953 2003
586
The origin of the neoplastic stromal cell in giant cell tumor of bone. 61
14608531 2003
587
Radiotherapy in the management of giant cell tumor of bone. 61
12909228 2003
588
Multicentric giant cell tumor of bone: ten lesions at presentation. 61
12879297 2003
589
Distal radioulnar allograft reconstruction after giant cell tumor resection. 61
12943342 2003
590
[Surgical treatment of giant cell tumor of bone]. 61
12970996 2003
591
Expression of VEGF and MMP-9 in giant cell tumor of bone and other osteolytic lesions. 61
12850503 2003
592
Expression and localization of extracellular matrix metalloproteinase inducer in giant cell tumor of bone. 61
12898514 2003
593
Radiology case of the month. Rapidly expanding tumor of bone. Cystic giant cell tumor of bone. 61
14506822 2003
594
Stimulated type I collagen turnover in patients with giant cell tumor of bone. 61
14506947 2003
595
[Non-differentiated carcinoma with osteoclast-like giant cells of the pancreas]. 61
12909827 2003
596
[Giant-cell tumor of the bone]. 61
12866146 2003
597
Malignancy in giant cell tumor of bone. 61
12733152 2003
598
Multicentric giant cell tumor of bone: a case report and review of the literature. 61
12771839 2003
599
Tc-99m-tetrofosmin scintigraphy in a primary giant cell tumor of bone with pulmonary metastases. 61
12790366 2003
600
Malignancy in giant cell tumor. 61
12605278 2003
601
Identification of markers of possible prognostic value in 57 giant cell tumors of bone. 61
12579271 2003
602
Cyclin alterations in giant cell tumor of bone. 61
12640100 2003
603
[Clinical manifestations of giant cell tumor of bone]. 61
12712622 2003
604
[Modern methods of diagnosis of giant-cell tumor of bone]. 61
12774480 2003
605
Surgical treatment and prognostic factors in giant-cell tumor of bone. 61
12882097 2003
606
Expression of parathyroid hormone (PTH)-related peptide (PthrP) and PTH/PTHrP receptor in osteoclast-like giant cells. 61
12747470 2003
607
[The role of radiotherapy in the treatment of bone neoplasms]. 61
12491046 2002
608
Giant cell tumor of bone. 61
12354366 2002
609
[Histogenesis of giant cell tumors]. 61
12376858 2002
610
Vascularized fibular graft after excision of giant-cell tumor of the distal radius: wrist arthroplasty versus partial wrist arthrodesis. 61
12087240 2002
611
Giant-cell tumor of the appendicular skeleton. 61
12072763 2002
612
Dedifferentiated chondrosarcoma with a noncartilaginous component mimicking a conventional giant cell tumor of bone. 61
12089726 2002
613
Giant cell tumor of long bone: a Canadian Sarcoma Group study. 61
11953616 2002
614
Customized treatment algorithm for giant cell tumor of bone: report of a series. 61
11953617 2002
615
Skin metastasis from conventional giant cell tumor of bone: conceptual significance. 61
11935202 2002
616
Clonality studies in giant cell tumor of bone. 61
11918322 2002
617
Oncologic and functional results after treatment of giant cell tumors of bone. 61
11995874 2002
618
Giant cell tumor of bone. The role of fibroblast growth factor 3 positive mesenchymal stem cells in its pathogenesis. 61
12865629 2002
619
Giant-cell tumor of bone arising from the falx cerebri. A case report. 61
11989858 2002
620
[Expression of ADAM12 (Meltrin-alpha) gene in giant cell tumor of bone]. 61
11769731 2001
621
Multifocal giant cell tumour of bone in a skeletally immature patient--a case report. 61
12035373 2001
622
Unicameral bone cyst of a cervical vertebral body and lateral mass with associated pathological fracture in a child. Case report and review of the literature. 61
11599845 2001
623
Characterizations of recombinant human tartrate-resistant acid phosphatase from osteosarcoma: comparison study between recombinant and placental proteins. 54
11838317 2001
624
Primary giant cell tumor of soft tissue. 61
11553317 2001
625
[Expression and significance of urokinase-type plasminogen activator, its receptor, and type 2 inhibitor in giant cell tumor of bone]. 61
11810768 2001
626
No EWS/FLI1 fusion transcripts in giant-cell tumors of bone. 61
11519035 2001
627
The nature of giant cell tumor of bone. 61
11501745 2001
628
Prognosis of giant cell tumor of bone. Histopathological analysis of 15 cases and review of the literature. 61
11753878 2001
629
Discovery of a novel antitumor benzolactone enamide class that selectively inhibits mammalian vacuolar-type (H+)-atpases. 61
11259534 2001
630
Efficacy of radiotherapy for giant cell tumor of bone: given either postoperatively or as sole treatment. 61
11286829 2001
631
[A case of giant cell tumor originating from the rib]. 61
11244761 2001
632
De novo malignant transformation of giant cell tumor of bone. 61
11310196 2001
633
Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR. 61
11310346 2001
634
[Repair of bone defect with benign tumor by embryonic bone transplantation]. 61
12563921 2001
635
Primary giant cell tumor of soft tissues similar to bone giant cell tumor: A case report and literature review. 61
11148467 2001
636
Malignant transformation of a giant cell tumor 25 years after initial treatment. 61
11127655 2000
637
Cytogenetic-morphologic correlations in aneurysmal bone cyst, giant cell tumor of bone and combined lesions. A report from the CHAMP study group. 61
11106078 2000
638
Binuclear cells induced by acridine orange in giant cell tumor of bone. 61
11062716 2000
639
Identification of EWS/FLI-1 transcripts in giant-cell tumor of bone. 61
10897036 2000
640
Relationship between binuclear and multinuclear cells in giant cell tumor of bone. 61
10953311 2000
641
Spindle-shaped cells derived from giant-cell tumor of bone support differentiation of blood monocytes to osteoclast-like cells. 61
11052502 2000
642
The localization of thyroid hormone receptor mRNAs in human bone. 54
10807056 2000
643
A CD36-binding peptide from thrombospondin-1 can stimulate resorption by osteoclasts in vitro. 54
10772961 2000
644
Gene expression of osteoprotegerin ligand, osteoprotegerin, and receptor activator of NF-kappaB in giant cell tumor of bone: possible involvement in tumor cell-induced osteoclast-like cell formation. 61
10702390 2000
645
The human tartrate-resistant acid phosphatase (TRAP): involvement of the hemin responsive elements (HRE) in transcriptional regulation. 54
10784406 2000
646
Primary giant cell tumor of soft tissues: a study of 22 cases. 61
10680893 2000
647
Giant cell tumor of rib--rare location on the anterior aspect. 61
10738893 2000
648
Apoptosis in giant cell tumors of bone. 61
10948650 2000
649
[The comparative biochemical and morphological characteristics of chondrosarcoma and giant-cell tumor of the bone]. 61
10976275 2000
650
Comparative frequency of bone sarcomas among different racial groups. 61
11721448 1999
651
[V-ATPase inhibitor baflomycine A1 inhibits bone resorption by osteoclast-like cells]. 61
11869558 1999
652
A lung metastasis from giant cell tumor of bone at eight years after primary resection. 61
10658380 1999
653
Megavoltage radiation therapy for axial and inoperable giant-cell tumor of bone. 61
10565648 1999
654
Telomeric fusion is a major cytogenetic aberration of giant cell tumors of bone. 61
10643009 1999
655
Localization of RANKL (receptor activator of NF kappa B ligand) mRNA and protein in skeletal and extraskeletal tissues. 61
10574572 1999
656
Interleukin-1beta upregulates MMP-9 expression in stromal cells of human giant cell tumor of bone. 61
10547161 1999
657
The developing concept of giant cell tumor of bone: a summary of serial basic studies. 61
11717973 1999
658
Expression of members of the thrombospondin family by human skeletal tissues and cultured cells. 54
10491303 1999
659
Soft tissue giant cell tumor of low malignant potential: a proposal for the reclassification of malignant giant cell tumor of soft parts. 61
10496598 1999
660
Treatment of giant-cell tumors of long bones with curettage and bone-grafting. 61
10391546 1999
661
Effect of cytokines on in vitro bone resorption by cells isolated from giant cell tumor of bone. 61
11593516 1999
662
Radiation treatment of benign mesenchymal disease. 61
10092709 1999
663
Radiation therapy in the treatment of giant cell tumor of bone. 61
10192357 1999
664
[Physiopathology of tumor-induced osteolysis]. 61
10327468 1999
665
Cytofluorometric DNA ploidy analysis in giant cell tumor of bone: histologic and prognostic value. 61
10355752 1999
666
Pseudoanaplastic giant cell tumor of bone. 61
10050793 1999
667
Cryosurgery in the treatment of giant cell tumor. A long-term followup study. 61
10078141 1999
668
Transcriptional regulation of MMP-9 expression in stromal cells of human giant cell tumor of bone by tumor necrosis factor-alpha. 61
9917505 1999
669
[The relationship between surgical staging, pathologic grading, operative type and postoperative recurrence in giant cell tumor of bone]. 61
11938783 1999
670
[Treatment of giant cell tumor of bone: surgery or radiotherapy?]. 61
10765483 1999
671
Giant cell tumor of bone. 61
10509202 1999
672
Bone tumors in the pelvis presenting growth during pregnancy. 61
10076940 1999
673
Giant cell tumor of bone in an aged Fischer 344 rat. 61
9864098 1998
674
Human osteoclasts and osteoclast-like cells synthesize and release high basal and inflammatory stimulated levels of the potent chemokine interleukin-8. 61
9751519 1998
675
Update on giant cell tumor of bone. 61
9801847 1998
676
Giant cell tumor of bone: a clinicopathologic study of prognostic factors. 61
9778111 1998
677
[Analysis of X-ray images of giant-cell tumor of bone of rare locations]. 61
10921038 1998
678
[A preliminary clinical observation of giant cell tumor of bone treated by adriamycin-loaded chitosan drug delivery system]. 61
10437104 1998
679
Gene expression of monocyte chemoattractant protein-1 in giant cell tumors of bone osteoclastoma: possible involvement in CD68+ macrophage-like cell migration. 61
9632113 1998
680
Giant cell tumor of bone with selective metastases to mediastinal lymph nodes. 61
9677653 1998
681
[Giant-cell tumor of bone]. 61
9773536 1998
682
Giant cell tumor of bone: an immunohistochemical comparative study. 61
9704342 1998
683
Giant cell tumor of bone: oncological and functional results of long-term follow-up. 61
9703860 1998
684
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas and periampullary region. 61
9529019 1998
685
[Giant cell tumors of the distal end of the radius treated by resection-arthrodesis]. 61
9586249 1998
686
Imprint cytology of chondroblastoma of bone. A case report. 61
9568146 1998
687
Osteoclasts from human giant cell tumors of bone lack estrogen receptors. 61
9492061 1998
688
Treatment of giant cell tumor of bone: a comparison of local curettage and wide resection. 61
9607262 1998
689
Multicentric giant cell tumor with viral-like inclusions associated with Paget's disease of bone: a case treated by steroid therapy. 61
9468548 1998
690
Factor XIIIa-immunoreactivity in tumors of the central nervous system. 61
9561329 1998
691
P2Y2 receptors are expressed by human osteoclasts of giant cell tumor but do not mediate ATP-induced bone resorption. 61
9514211 1998
692
[Differential diagnosis of giant cell tumor of bone]. 61
10095427 1998
693
Giant cell tumor of bone. 61
9553696 1998
694
[Primary hyperparathyroidism diagnosed as a multicentric giant cell tumor of bone--case report]. 61
10224871 1998
695
Prognostic relevance of C-myc gene expression in giant-cell tumor of bone. 61
9565066 1998
696
[Giant cell tumor of bone. Morphological, immunohistochemical, morphometric and DNA flow cytometric findings]. 61
10095447 1998
697
Clear cell tumors of bone. 61
9383827 1997
698
[Alterations of retinoblastoma gene and its protein expression in aggressive bone tumors]. 61
10374331 1997
699
[Alterations of MDM2 and p53 genes in bone tumors]. 61
10374333 1997
700
[Promotive effect of TNF-alpha and M-CSF on osteolysis induced by giant cell tumor of bone]. 61
10374334 1997
701
Giant cell tumor of bone: frequent actin immunoreactivity in stromal tumor cells. 61
9361101 1997
702
Radiology case of the month. Delayed treatment of a large, fungating mass. Benign giant-cell tumor of bone. 61
9347632 1997
703
Multicentric giant cell tumor of bone--a case report and comprehensive review of literature. 61
9491674 1997
704
[A case of multicentric intraosseous well differentiated osteosarcoma originating in the rib]. 61
9301243 1997
705
[Giant-cell tumor of bone: a review of diagnosis and treatment of 105 cases]. 61
11038769 1997
706
Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone. 61
9219728 1997
707
Giant cell tumor of bone. Prognosis and treatment of pulmonary metastases. 61
9170381 1997
708
Benign giant cell tumor of bone with osteosarcomatous transformation ("dedifferentiated" primary malignant GCT): report of two cases. 61
9151375 1997
709
Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study. 61
9111508 1997
710
Cytologic findings in tenosynovial giant cell tumors investigated by fine-needle aspiration cytology. 61
9143824 1997
711
Giant-cell tumor of bone around the knee. 61
9216120 1997
712
Analysis of giant cell tumor of bone with pulmonary metastases. 61
9020226 1997
713
Late malignant transformation of a benign giant-cell tumor of bone. A case report. 61
9052550 1997
714
Recurrence of giant cell tumor of bone: the role of MRI in diagnosis. 61
9122055 1997
715
Giant cell tumors of the bones of the hand. 61
9018620 1997
716
Expression of metalloproteinases and tissue inhibitors of metalloproteinases in giant cell tumor of bone: an immunohistochemical study with clinical correlation. 61
8912822 1996
717
Giant cell tumor of bone in children and adolescents. 61
8938873 1996
718
Human cord blood monocytes undergo terminal osteoclast differentiation in vitro in the presence of culture medium conditioned by giant cell tumor of bone. 61
8816903 1996
719
Uterine leiomyosarcoma with osteoclast-like giant cells: histopathological and cytological observations. 61
8905874 1996
720
[A case of giant cell tumor originating in the rib]. 61
8828373 1996
721
Human calcitonin has the same inhibitory effect on osteoclastic bone resorption by human giant cell tumor cells as salmon calcitonin. 61
8687977 1996
722
Methotrexate eluted from bone cement: effect on giant cell tumor of bone in vitro. 61
8653971 1996
723
Chromosomal anomalies exclusive of telomeric associations in giant cell tumor of bone. 61
8640728 1996
724
Use of preoperative autologous blood donations and erythropoietin for treatment of giant cell tumor of the ischium. 61
8620648 1996
725
Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts. 54
8647859 1996
726
Lack of microsatellite instability in giant cell tumor of bone. 61
8630976 1996
727
A flow cytometric study on giant cell tumor of bone. 61
8758338 1996
728
Giant cell tumor of bone. 61
8625607 1996
729
Production of interleukin-6 by human osteoclast-like cells from giant cell tumor of bone. 61
21544359 1996
730
Matrix metalloproteinase 9 (gelatinase B) is expressed in multinucleated giant cells of human giant cell tumor of bone and is associated with vascular invasion. 61
8579123 1996
731
Chromosome telomere integrity of human solid neoplasms. 61
8616786 1996
732
Multicentric giant cell tumor of bone. 61
8542701 1996
733
[Resection of cranial base tumors]. 61
9642358 1996
734
Benign giant-cell tumor of bone with metastasis to mediastinal lymph nodes. A case report of resection facilitated with use of steroids. 61
8550667 1996
735
Interleukin-6 and soluble interleukin-6 receptors in the synovial fluids from rheumatoid arthritis patients are responsible for osteoclast-like cell formation. 61
8770701 1996
736
MR findings indicative of hemosiderin in giant-cell tumor of bone: frequency, cause, and diagnostic significance. 61
8571864 1996
737
[Molecular weight determination and protein analysis of GCF-5 antigens of giant cell tumor of bone]. 61
9275692 1996
738
Giant cell tumor of bone. Curettage and cement reconstruction. 61
7497676 1995
739
Detection of mRNAs for urokinase-type plasminogen activator, its receptor, and type 1 inhibitor in giant cell tumors of bone with in situ hybridization. 61
7495280 1995
740
Cytogenetic, telomere, and telomerase studies in five surgically managed lumbosacral chordomas. 61
8536238 1995
741
Expression of 72 kDa and 92 kDa type IV collagenases from human giant-cell tumor of bone. 61
7586800 1995
742
Giant cell tumor of bone in the foot and ankle. 61
8574373 1995
743
Translocation of protein kinase C isoenzymes by elevated extracellular Ca2+ concentration in cells from a human giant cell tumor of bone. 61
8554927 1995
744
Giant cell tumor of the pancreas arising in the ovarian-like stroma of a mucinous cystadenocarcinoma. 61
7594774 1995
745
Expression of two human skeletal calcitonin receptor isoforms cloned from a giant cell tumor of bone. The first intracellular domain modulates ligand binding and signal transduction. 61
7769107 1995
746
Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution. 54
7576232 1995
747
Fine needle aspiration diagnosis of aggressive giant cell tumor of bone. A case report. 61
7762351 1995
748
Prolonged disease-free survival following surgical debulking and high-dose cisplatin/doxorubicin in a patient with bulky metastases from giant cell tumor of bone refractory to "standard" chemotherapy. 61
7900706 1995
749
Telomerase activity and oncogenesis in giant cell tumor of bone. 61
7850706 1995
750
[Chromosome study on giant cell tumor of bone]. 61
7656714 1995
751
Generation and characterization of putative monoclonal and polyclonal antibodies against tartrate-resistant acid phosphatase. 54
7768539 1995
752
Giant cell tumor of bone: problems of differential diagnosis: 1944. 61
8800809 1995
753
Giant-cell tumor of the distal phalanx of the hand in a child. 61
7641439 1995
754
Giant cell tumor of bone: oncologic and functional results. 61
7990480 1994
755