Bone Inflammation Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BNN003 MIFTS: 48	Bone Inflammation Disease Categories: Bone diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease ¹¹ ¹⁴

Osteitis ¹¹ ⁴³ ¹⁴ ⁷¹

Inflammatory Disorder of Bone ¹¹

Bone Inflammatory Disease ¹¹

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:3342

MeSH ⁴³ D010000

SNOMED-CT ⁶⁸ 274144001

UMLS ⁷¹ C0029400

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Summaries for Bone Inflammation Disease

Disease Ontology: ¹¹ A bone disease that results in inflammation of the located in bone.

MalaCards based summary: Bone Inflammation Disease, also known as osteitis, is related to sapho syndrome and alveolar periostitis. An important gene associated with Bone Inflammation Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Toll-like receptor signaling pathway and Sudden infant death syndrome (SIDS) susceptibility pathways. The drugs Chlorhexidine and Zoledronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and prostate, and related phenotypes are immune system and hematopoietic system

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Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1102)

#	Related Disease	Score	Top Affiliating Genes
1	sapho syndrome	33.2	TNF CRP CCR6
2	alveolar periostitis	32.6	TNF IL6 CRP
3	spondyloarthropathy 1	32.4	TNF IL6 IL1B ICOSLG CRP CCR6
4	osteomyelitis	32.4	TNF IL6 IL1B CRP
5	synovitis	32.0	TNF IL6 IL1B CRP
6	acne	32.0	TNF IL6 IL1B CRP
7	pustulosis of palm and sole	31.8	TNF SERPINA3 CRP CCR6
8	chronic recurrent multifocal osteomyelitis	31.8	TNF IL6 IL1B CRP
9	common cold	31.6	TNF IL6 IL1B ICOSLG CRP CCR6
10	spondylitis	31.6	TNF IL6 IL1B CRP CCR6
11	syphilis	31.5	TNF MIR142 CRP CCR6
12	bone disease	31.4	TNF SERPINA3 MIR34A MIR223 MIR210 MIR21
13	back pain	31.3	IL6 IL1B CRP
14	rheumatoid arthritis	31.3	TNF SERPINA3 MIR155 MIR146A IL6 IL1B
15	periostitis	31.2	TNF IL1B CRP
16	septic arthritis	31.2	TNF IL6 IL1B CRP
17	typhoid fever	31.1	TNF IL6 IL1B CRP CCR6
18	psoriatic arthritis	31.1	TNF MIR146A IL6 IL1B ICOSLG CRP
19	spondyloarthropathy	31.0	TNF IL6 IL1B ICOSLG CRP CCR6
20	tenosynovitis	31.0	TNF IL6 IL1B CRP
21	osteoporosis	31.0	TNF MIR210 MIR21 MIR140 IL6 IL1B
22	enthesopathy	31.0	TNF CRP CCR6
23	pulpitis	31.0	TNF IL6 IL1B
24	chronic kidney disease	31.0	TNF MIR21 MIR126 IL6 IL1B CRP
25	meningitis	30.9	TNF IL6 IL1B CRP
26	sarcoidosis 1	30.9	TNF SERPINA3 MIR155 IL6 IL1B ICOSLG
27	brucellosis	30.9	TNF IL6 CRP
28	leprosy 3	30.9	TNF SERPINA3 IL6 IL1B CCR6
29	pyoderma	30.9	TNF IL1B CRP CCR6
30	paratyphoid fever	30.8	TNF IL1B CRP
31	kidney disease	30.8	TNF MIR21 MIR199A1 IL6 IL1B CRP
32	periodontitis	30.8	TNF SERPINA3 MIR21 MIR17 MIR142 MIR125A
33	osteoarthritis	30.8	TNF MIR140 IL6 IL1B CRP
34	dermatitis	30.8	TNF IL6 IL1B CCR6
35	histiocytosis	30.8	TNF SERPINA3 CCR6
36	pyoderma gangrenosum	30.8	TNF IL1B CCR6
37	ankylosis	30.8	TNF CRP CCR6
38	arthropathy	30.8	TNF IL6 IL1B CRP CCR6
39	langerhans cell histiocytosis	30.8	TNF SERPINA3 ICOSLG CCR6
40	exanthem	30.8	TNF IL6 IL1B ICOSLG H2AC18 CRP
41	aspergillosis	30.8	TNF IL6 IL1B CCR6
42	paine syndrome	30.8	TNF IL6 IL1B H2AC18
43	labyrinthitis	30.8	TNF IL1B CRP
44	tonsillitis	30.8	TNF IL6 IL1B
45	toxic shock syndrome	30.7	TNF IL6 IL1B CRP
46	sickle cell anemia	30.7	TNF IL6 H2AC18 CRP
47	tetanus	30.7	TNF IL6 IL1B CRP
48	rhinitis	30.7	TNF IL6 IL1B ICOSLG
49	bone cancer	30.7	SERPINA3 MIR34A MIR223 MIR210 MIR21 MIR199A1
50	reactive arthritis	30.7	TNF CRP CCR6

Graphical network of the top 20 diseases related to Bone Inflammation Disease:

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Symptoms & Phenotypes for Bone Inflammation Disease

MGI Mouse Phenotypes related to Bone Inflammation Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.83	CCR6 CRP ICOSLG IL1B IL6 MIR125A
2	hematopoietic system	MP:0005397	9.47	CCR6 ICOSLG IL1B IL6 MIR125A MIR126

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Drugs & Therapeutics for Bone Inflammation Disease

Drugs for Bone Inflammation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Chlorhexidine

Approved, Vet_approved, Withdrawn

Phase 4

55-56-1

2713 9552079

Zoledronic acid

Approved

Phase 4

118072-93-8

68740

Alendronic acid

Approved

Phase 4

121268-17-5, 66376-36-1

2088

Pamidronic acid

Approved

Phase 4

40391-99-9

4674

Cholecalciferol

Approved, Nutraceutical, Vet_approved

Phase 4

67-97-0, 1406-16-2

5280795 10883523

Calcium, Dietary

Phase 4

Chlorhexidine gluconate

Phase 4

Vitamins

Phase 4

Trace Elements

Phase 4

Calciferol

Phase 4

Micronutrients

Phase 4

Diphosphonates

Phase 4

Calcium

Nutraceutical

Phase 4

7440-70-2

271

Risedronic acid

Approved, Investigational

Phase 3

105462-24-6

5245

Etidronic acid

Approved

Phase 3

2809-21-4, 7414-83-7

3305

Antibiotics, Antitubercular

Phase 3

Anti-Bacterial Agents

Phase 3

Anti-Infective Agents

Phase 3

Hormones

Phase 3

calcium channel blockers

Phase 3

Hydrogen peroxide

Approved, Vet_approved

Phase 2

7722-84-1

784

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 2

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 2

50-02-2

3003 5743

Octenidine

Investigational

Phase 2

71251-02-0

Pharmaceutical Solutions

Phase 2

Anti-Inflammatory Agents

Phase 2

Gastrointestinal Agents

Phase 2

Antineoplastic Agents, Hormonal

Phase 2

Dexamethasone 21-phosphate

Phase 2

Hormone Antagonists

Phase 2

Antiemetics

Phase 2

HIV Protease Inhibitors

Phase 2

glucocorticoids

Phase 2

BB 1101

Phase 2

protease inhibitors

Phase 2

Acetylsalicylic acid

Approved, Vet_approved

50-78-2

2244

Tetracycline

Approved, Vet_approved, Withdrawn

60-54-8

5353990

Menthol

Approved, Experimental

1490-04-6, 2216-51-5, 15356-60-2

1254 16666 165675

Sorbitol

Approved, Investigational

69-65-8, 50-70-4

453 6251 5780

Peppermint oil

Approved, Investigational

8006-90-4

Peppermint

Approved

Silicon

Approved, Investigational

7440-21-3

4082203

Tocopherol

Approved, Investigational

1406-66-2

Hyaluronic acid

Approved, Vet_approved

9004-61-9

53477741

Eugenol

Approved

97-53-0

3314

Infliximab

Approved

170277-31-3

DL-alpha-Tocopherol

Approved, Experimental, Investigational, Nutraceutical, Vet_approved

59-02-9, 10191-41-0

2116 14985

Ascorbic acid

Approved, Nutraceutical

50-81-7

54676860 54670067 5785

Tocotrienol

Investigational

6829-55-6

9929901

Analgesics

Interventional clinical trials:

(show all 36)

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of DC071 Mouthwash (0.2% Chlorhexidine Digluconate) in Peri-surgical Care for Preventing Alveolar Osteitis After Third Molar Extraction	Completed	NCT02382809	Phase 4	DC071;Placebo
2	A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China	Completed	NCT00774020	Phase 4	Zoledronic acid
3	An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies	Completed	NCT00740129	Phase 4	Zoledronic Acid
4	Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation	Completed	NCT00668200	Phase 4	Reclast (ZOL446, zoledronic acid)
5	Bisphosphonate Therapy for Osteogenesis Imperfecta	Completed	NCT00159419	Phase 4	Alendronate;Pamidronate
6	Open Label Study to Describe the Effect of Tocilizumab in Combination With MTX in the Evolution of Articular Damage (Synovitis/Osteitis and Erosions) Evaluated by MRI in the Hand of Patients With Moderate to Severe Rheumatoid Arthritis (RA) and Inadequate Response to Non-biological DMARDs	Withdrawn	NCT01878318	Phase 4	methotrexate;tocilizumab [RoActemra/Actemra]
7	Antibiotic Efficacy in Third Molar Surgery	Completed	NCT00118820	Phase 3	IV Preoperative antibiotic or placebo
8	A 6-Month, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Alendronate 280-mg Oral Buffered Solution Once Weekly in Patients With Paget's Disease of Bone	Completed	NCT00480662	Phase 3	alendronate
9	Randomized, Double-blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observational Period	Completed	NCT00051636	Phase 3	Zoledronic Acid;Risedronate;Placebo to Risedronate;Placebo to Zoledronic Acid
10	Randomized, Double-Blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observation Period	Completed	NCT00103740	Phase 3	zoledronic acid;placebo to zoledronic acid;Risedronate;Placebo to risedronate;Calcium and vitamin D supplements
11	Multi-centre, Open-label, First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro	Completed	NCT04091399	Phase 2	Stamatological tamponade Contipro
12	Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial	Suspended	NCT03606980	Phase 2	Dexamethasone Sodium Phosphate
13	Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders	Unknown status	NCT00403598
14	Characterizing Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) With 68Ga-FAPI PET/CT	Unknown status	NCT04596462	Early Phase 1	68Ga-FAPI
15	Allogenic Vascularized Knee and Femur Transplantation Clinical Evaluation	Unknown status	NCT01133145
16	Evaluation of Platelet Rich Fibrin Use in the Treatment of Dry Socket.	Unknown status	NCT04476121		Nipas application
17	Comparison of Three Treatments for Lower Extremity Apophysitis	Unknown status	NCT01826071
18	Effect of Concentrated Growth Factors on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Study	Completed	NCT04151147
19	Pressure Sore-related Osteitis Treated by Flap Coverage and Short Antibiotic Regimen	Completed	NCT03964818
20	Clinical Investigation of the Efficacy of CGF (Concentrated Growth Factor) and Ozone in the Treatment of Alveolar Osteitis	Completed	NCT04507009
21	A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery	Completed	NCT03494972		Tetracyclin ointment
22	Post-transition Clinical and Socio-professional Future in Adult Patients With Recurrent Multifocal Chronic Osteitis	Completed	NCT05103137
23	Effect of NBF Gingival Gel Application in Controlling Post-surgical Complications After Impacted Lower Third Molar Surgery	Completed	NCT03641482		NBF
24	Genetic Study of Families Affected by Paget's Disease of Bone	Completed	NCT00747994
25	Sodium Risedronate 17.5 mg Tablets Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) - 48-week Surveillance -	Completed	NCT02106455		Sodium risedronate
26	Use of 18F-Fluoride Positron Emission Tomography in the Assessment and Evaluation of Therapy in Monostotic Paget's Disease of Bone	Completed	NCT00306046		Bisphosphonate treatment
27	Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial	Completed	NCT03960086
28	A Clinical Investigation of the Efficacy of Platelet Rich Fibrin (Bio-PRF) Compared to Alveogyl in the Treatment of Alveolar Osteitis	Recruiting	NCT05615272		Alveogyl
29	Effect of Hyaluronic Acid on the Therapy of Alveolar Osteitis - A Double-blind, Randomized Controlled Clinical Trial	Recruiting	NCT04853589
30	Bone Flap Osteomyelitis Following Craniectomy : Retrospective Evaluation of Clinical Presentation, Microbiological Diagnosis and Management	Recruiting	NCT05367713
31	Prediction of IBD Disease Activity in Individual Patients Based on PROMs and Clinical Data	Recruiting	NCT05578768
32	Infliximab Proactive Drug Monitoring in the Pediatric IBD Population	Recruiting	NCT04921670
33	Genetic Analysis to Predict the Development of Paget's Disease	Recruiting	NCT05309954
34	Characterization of Familial Myopathy and Paget Disease of Bone	Recruiting	NCT01353430
35	Investigation of Pathophysiology of Angiogenesis and Osteogenesis in Paget's Disease of Bone	Active, not recruiting	NCT02802384
36	Management of Lower Limb Apophysitis: A Cross-sectional Study on Long-term Impact on Health Status	Enrolling by invitation	NCT04313621

Search NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

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Genetic Tests for Bone Inflammation Disease

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Anatomical Context for Bone Inflammation Disease

Organs/tissues related to Bone Inflammation Disease:

FMA: Bone

MalaCards : Bone, Bone Marrow, Prostate, Spinal Cord, Skin, Kidney, Thyroid

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Publications for Bone Inflammation Disease

Articles related to Bone Inflammation Disease:

(show top 50) (show all 4815)

#	Title	Authors	PMID	Year
1	Presence of axial spondyloarthritis associated sacroiliitis and structural changes on MR enterography: A direct comparison with sacroiliac joint MRI. ⁶²	Ergenc I...Atagunduz MP	36152432	2022
2	Survey of the treatment outcome of patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis. ⁶²	Hiraiwa T...Yamamoto T	35983683	2022
3	Clinical and Epidemiologic Characteristics and Therapeutic Management of Patients with Vibrio Infections, Bay of Biscay, France, 2001-2019. ⁶²	Hoefler F...Allix-Beguec C	36418019	2022
4	The "Hand as Foot" teaching method in whole-body bone scintigraphy of synovitis-acne-pustulosishyperostosis-osteitis syndrome. ⁶²	Niu R...He Y	35773110	2022
5	A Rare Cause of Postpartum Back Ache: Osteitis Condensans Ilii. ⁶²	Khan A...Pankaj A	36457436	2022
6	Regional antibiotic perfusion through the lateral saphenous vein in two horses with septic calcaneal osteitis. ⁶²	Mizuguchi Y...Aizu M	36418075	2022
7	Intra-articular Soft Tissue Pathology of the Postpartum Hip: A Systematic Review. ⁶²	Hoffer AJ...Lodhia P	36350530	2022
8	Towards a simplified fluid-sensitive MRI protocol in small joints of the hand in early arthritis patients: reliability between modified Dixon and regular Gadolinium enhanced TSE fat saturated MRI-sequences. ⁶²	Boeren AMP...van der Helm-van Mil AHM	36441238	2022
9	Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome associated with pyoderma gangrenosum: report of two patients. ⁶²	Ma M...Li C	36345566	2022
10	[Emergency free flap in reconstruction of the lower limb: About 23 cases over 11 years]. ⁶²	Renom M...Pluvy I	36463023	2022
11	Implementation of the OMERACT Psoriatic Arthritis Magnetic Resonance Imaging Scoring System in a randomized phase IIb study of abatacept in psoriatic arthritis. ⁶²	Ostergaard M...Conaghan PG	35137002	2022
12	Coincidence of pachydermoperiostosis and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, a causal or casual association? ⁶²	Feng Y...Wei S	35938529	2022
13	Viral infections in orthopedics: A systematic review and classification proposal. ⁶²	Sidiropoulos K...Kavarthapu V	36439372	2022
14	Malignant external otitis complicated by spinal cord compression: Case report. ⁶²	Eddine HS...Mahtar M	36389183	2022
15	Standardized reporting and quantification of whole-body MRI findings in children with chronic non-bacterial osteomyelitis treated with pamidronate. ⁶²	Andreasen CM...Jurik AG	36183086	2022
16	Value of a lateral inferior pedicle flap in Draf IIb for recurrent frontal sinus diseases: a prospective study. ⁶²	He C...Zhen HT	35220482	2022
17	How Has Molecular Biology Enhanced Our Undertaking of axSpA and Its Management. ⁶²	Fatica M...Chimenti MS	36308677	2022
18	Intermetatarsal Bursitis, a Novel Feature of Juxtaarticular Inflammation in Early Rheumatoid Arthritis Related to Clinical Signs: Results of a Longitudinal Magnetic Resonance Imaging Study. ⁶²	van Dijk BT...van der Helm-van Mil AHM	33973415	2022
19	Work productivity and activity in patients with SAPHO syndrome: a cross-sectional observational study. ⁶²	Li C...Sun L	36271426	2022
20	Successful treatment of nail involvement using leflunomide in a patient with synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. ⁶²	Li Z...Li C	36309922	2022
21	Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata. ⁶²	Liu S...Li C	36224598	2022
22	The efficacy of minocycline hydrochloride ointment versus iodoform gauze for alveolar osteitis: A prospective cohort study. ⁶²	Sun YQ...Zhao JH	36258229	2022
23	Hemostatic Alginate/Nano-Hydroxyapatite Composite Aerogel Loaded with Tranexamic Acid for the Potential Protection against Alveolar Osteitis. ⁶²	El Halawany M...AbouGhaly MHH	36297689	2022
24	Is Chitosan Dental Dressing Better Than Cotton Gauze in Achieving Hemostasis in Patients on Antithrombotics? ⁶²	Radhakrishna S...Shetty SK	36403660	2022
25	Performance of an MRI scoring system for inflammation of joints and entheses in peripheral SpA: post-hoc analysis of the CRESPA trial. ⁶²	Krabbe S...Ostergaard M	36200875	2022
26	Hand and foot MRI in contemporary undifferentiated arthritis: in which patients is MRI valuable to detect rheumatoid arthritis early? A large prospective study. ⁶²	den Hollander NK...van der Helm-van Mil AHM	35022703	2022
27	Hip Range of Motion and Strength in Male Athletes with Stage 1 Osteitis Pubis: A Cross-Sectional and Correlational Study. ⁶²	Ceballos-Laita L...Jimenez-Del-Barrio S	36232123	2022
28	Efficacy and safety of guselkumab and adalimumab for pustulotic arthro-osteitis and their impact on peripheral blood immunophenotypes. ⁶²	Ueno M...Tanaka Y	36303202	2022
29	Athletic Osteitis Pubis Detected on 18 F-FDG PET/CT. ⁶²	Broos WAM...Knol RJJ	35452006	2022
30	Tympanic bullae ultrasonography is feasible in nonsedated healthy rabbits (Oryctolagus cuniculus). ⁶²	Coeuriot CTN...Fusellier MS	36170214	2022
31	Metallosis after using distal fibular locking plate for lateral malleolar fractures: a retrospective study. ⁶²	Park SJ...Kwon DG	33646355	2022
32	Diagnostic Accuracy of Standalone T2 Dixon Sequence Compared with Conventional MRI in Sacroiliitis. ⁶²	Athira R...Nedunchelian M	36177276	2022
33	Effectiveness of Honey in the Treatment and Prevention of Alveolar Osteitis: Systematic Review and Meta-analysis. ⁶²	de la Puente Dongo JL...Teixeira RG	36274888	2022
34	Occult Pulmonary Neuroendocrine Tumor Causing Severe Hyperparathyroidism: Diagnostic Challenges and Clinical Outcomes. ⁶²	Yazdian A...Vaz CL	36189140	2022
35	Local interventions for the management of alveolar osteitis (dry socket). ⁶²	Daly BJ...Beattie A	36156769	2022
36	Synovitis-acne-pustulosis-hyperostosis-osteitis Syndrome with Bilateral Pleural Effusion. ⁶²	Adachi-Katayama M...Matsumoto I	35135914	2022
37	Does SAPHO syndrome exist in dermatology? ⁶²	Chen W...Plewig G	35462435	2022
38	Analysis of metabolites of fungal balls in the paranasal sinuses. ⁶²	Zhang X...Zhou B	36100882	2022
39	Radiosurgery for Benign Vertebral Body Hemangiomas of the Spine: A Systematic Review and Meta-Analysis. ⁶²	Conti A...Tuleasca C	35378316	2022
40	Characteristics and incidence of vaccine adverse events after Bacille Calmette-Guérin vaccination: A national surveillance study in Japan from 2013 to 2017. ⁶²	Okuno H...Tanaka-Taya K	35690499	2022
41	Osteitis Condensans Ilii: A Case Series. ⁶²	Sathu S...Maley DK	36148199	2022
42	Acetabular fixation in total hip arthroplasty in the previously irradiated pelvis: a review of basic science and clinical outcomes. ⁶²	Connors JP...Solovyova O	35984490	2022
43	Clinical characteristics of pustulotic arthro-osteitis in Korea. ⁶²	Kim M...Youn SW	35510638	2022
44	Radiographic aspects in individuals infected by human T-lymphotropic virus type 1 (HTLV-1) with joint pain. ⁶²	da Silva Carvalho JM...Carvalho EM	35945643	2022
45	Efficacy of tranexamic acid in prevention of alveolar osteitis following surgical removal of impacted mandibular third molar. ⁶²	Jadhav AN...Deshmukh VD	36393943	2022
46	Plate-associated localized osteitis in mini-pig by biofilm-forming Methicillin-resistant Staphylococcus aureus (MRSA): establishment of a novel experimental model. ⁶²	Jaekel C...Grassmann JP	35201371	2022
47	The challenges in diagnosis and management of osteitis pubis: An algorithm based on current evidence. ⁶²	Amer ML...Khan MS	35783593	2022
48	Pustulotic arthro-osteitis (Sonozaky syndrome). ⁶²	Sakellariou GT...Tsifountoudis I	35156627	2022
49	Sclerosis of the clavicle--A challenging diagnosis. ⁶²	Davis TA...Belzarena AC	35570861	2022
50	Effect of initiating biologics compared to intensifying conventional DMARDs on clinical and MRI outcomes in established rheumatoid arthritis patients in clinical remission: Secondary analyses of the IMAGINE-RA trial. ⁶²	Moller-Bisgaard S...Ostergaard M	34474649	2022

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Genes for Bone Inflammation Disease

Genes related to Bone Inflammation Disease (0 elite genes):

(show top 50) (show all 93)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	15.16	DISEASES inferred ¹⁴ ¹⁴
2	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	13.1	DISEASES inferred ¹⁴ ¹⁴
3	MIR140	MicroRNA 140	RNA Gene	12.01	DISEASES inferred ¹⁴ ¹⁴
4	H2AC18	H2A Clustered Histone 18	Protein Coding	11.76	DISEASES inferred ¹⁴ ¹⁴
5	SERPINA3	Serpin Family A Member 3	Protein Coding	11.21	DISEASES inferred ¹⁴ ¹⁴
6	MIR155	MicroRNA 155	RNA Gene	11.1	DISEASES inferred ¹⁴ ¹⁴
7	MIR146A	MicroRNA 146a	RNA Gene	11.08	DISEASES inferred ¹⁴ ¹⁴
8	MIR223	MicroRNA 223	RNA Gene	10.59	DISEASES inferred ¹⁴ ¹⁴
9	MIR21	MicroRNA 21	RNA Gene	10.47	DISEASES inferred ¹⁴ ¹⁴
10	MIR142	MicroRNA 142	RNA Gene	10.42	DISEASES inferred ¹⁴ ¹⁴
11	TNF	Tumor Necrosis Factor	Protein Coding	10.21	DISEASES inferred ¹⁴
12	MIR34A	MicroRNA 34a	RNA Gene	10.1	DISEASES inferred ¹⁴ ¹⁴
13	IL6	Interleukin 6	Protein Coding	9.98	DISEASES inferred ¹⁴
14	IL1B	Interleukin 1 Beta	Protein Coding	9.96	DISEASES inferred ¹⁴
15	MIR125A	MicroRNA 125a	RNA Gene	9.9	DISEASES inferred ¹⁴ ¹⁴
16	MIR126	MicroRNA 126	RNA Gene	9.83	DISEASES inferred ¹⁴ ¹⁴
17	CRP	C-Reactive Protein	Protein Coding	9.71	DISEASES inferred ¹⁴
18	MIR17	MicroRNA 17	RNA Gene	9.65	DISEASES inferred ¹⁴ ¹⁴
19	MIR199A1	MicroRNA 199a-1	RNA Gene	9.62	DISEASES inferred ¹⁴ ¹⁴
20	MIR210	MicroRNA 210	RNA Gene	9.6	DISEASES inferred ¹⁴ ¹⁴
21	IL17A	Interleukin 17A	Protein Coding	9.59	DISEASES inferred ¹⁴
22	MIR127	MicroRNA 127	RNA Gene	9.38	DISEASES inferred ¹⁴ ¹⁴
23	CD4	CD4 Molecule	Protein Coding	9.37	DISEASES inferred ¹⁴
24	ACAN	Aggrecan	Protein Coding	9.36	DISEASES inferred ¹⁴
25	IL10	Interleukin 10	Protein Coding	9.3	DISEASES inferred ¹⁴
26	MIR22	MicroRNA 22	RNA Gene	9.25	DISEASES inferred ¹⁴ ¹⁴
27	MMP13	Matrix Metallopeptidase 13	Protein Coding	9.19	DISEASES inferred ¹⁴
28	MIR30A	MicroRNA 30a	RNA Gene	9.1	DISEASES inferred ¹⁴ ¹⁴
29	MIR29A	MicroRNA 29a	RNA Gene	9.04	DISEASES inferred ¹⁴ ¹⁴
30	MIR221	MicroRNA 221	RNA Gene	9.04	DISEASES inferred ¹⁴ ¹⁴
31	MIR23A	MicroRNA 23a	RNA Gene	9.03	DISEASES inferred ¹⁴ ¹⁴
32	TNFSF11	TNF Superfamily Member 11	Protein Coding	9.03	DISEASES inferred ¹⁴
33	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	9.02	DISEASES inferred ¹⁴
34	MIR24-1	MicroRNA 24-1	RNA Gene	8.99	DISEASES inferred ¹⁴ ¹⁴
35	MIR27A	MicroRNA 27a	RNA Gene	8.99	DISEASES inferred ¹⁴ ¹⁴
36	MMP3	Matrix Metallopeptidase 3	Protein Coding	8.98	DISEASES inferred ¹⁴
37	MIR214	MicroRNA 214	RNA Gene	8.94	DISEASES inferred ¹⁴ ¹⁴
38	MIR483	MicroRNA 483	RNA Gene	8.88	DISEASES inferred ¹⁴ ¹⁴
39	IL4	Interleukin 4	Protein Coding	8.86	DISEASES inferred ¹⁴
40	CD8A	CD8a Molecule	Protein Coding	8.82	DISEASES inferred ¹⁴
41	MIR132	MicroRNA 132	RNA Gene	8.76	DISEASES inferred ¹⁴ ¹⁴
42	IL2	Interleukin 2	Protein Coding	8.71	DISEASES inferred ¹⁴
43	MIR149	MicroRNA 149	RNA Gene	8.71	DISEASES inferred ¹⁴ ¹⁴
44	ADAMTS5	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5	Protein Coding	8.7	DISEASES inferred ¹⁴
45	MIR9-1	MicroRNA 9-1	RNA Gene	8.7	DISEASES inferred ¹⁴ ¹⁴
46	MIR122	MicroRNA 122	RNA Gene	8.69	DISEASES inferred ¹⁴ ¹⁴
47	MIR29B1	MicroRNA 29b-1	RNA Gene	8.66	DISEASES inferred ¹⁴ ¹⁴
48	TLR4	Toll Like Receptor 4	Protein Coding	8.62	DISEASES inferred ¹⁴
49	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	8.6	DISEASES inferred ¹⁴
50	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	8.59	DISEASES inferred ¹⁴

Sources

Variations for Bone Inflammation Disease

Sources

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Sources

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 25)

#	Super pathways	Score	Top Affiliating Genes
1	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.74	TNF MIR155 MIR146A IL6 IL1B
2	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.03	TNF MIR210 IL6 IL1B
3	MicroRNAs in cardiomyocyte hypertrophy ⁷⁴ Show member pathways Cardiac hypertrophic response ⁷⁴	11.98	MIR140 MIR199A1 MIR21 TNF
4	Innate Lymphoid Cells Differentiation ⁶⁵	11.69	TNF IL1B CCR6
5	Burn wound healing ⁷⁴	11.66	TNF IL6 IL1B
6	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.64	TNF IL6 IL1B
7	Lung fibrosis ⁷⁴	11.57	IL1B IL6 TNF
8	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.56	IL1B IL6 TNF
9	IL 10 signaling pathway ⁶⁷	11.54	TNF IL6 IL1B
10	Cell differentiation - expanded index ⁷⁴ Show member pathways Cell differentiation - index ⁷⁴	11.52	MIR155 MIR17 MIR199A1 MIR223
11	Hepatitis C and hepatocellular carcinoma ⁷⁴	11.48	MIR34A MIR155 IL6
12	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.41	TNF IL6 ICOSLG CRP
13	Interleukin-10 signaling ⁶⁶	11.4	TNF IL6 IL1B
14	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.37	TNF IL6 IL1B
15	miRNAs involved in DNA damage response ⁷⁴	11.28	MIR223 MIR210 MIR21 MIR17
16	IL-10 Pathway ⁶⁴	11.21	TNF IL6 IL1B
17	Development and heterogeneity of the ILC family ⁷⁴	11.16	TNF IL6 IL1B
18	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.11	TNF IL6 IL1B
19	Cytokines and inflammatory response ⁷⁴	11.07	TNF IL6 IL1B
20	Prostaglandin signaling ⁷⁴	11.03	TNF IL6 IL1B
21	Interactions between immune cells and microRNAs in tumor microenvironment ⁷⁴	10.94	MIR34A MIR210 MIR21 MIR146A
22	miRNAs involvement in the immune response in sepsis ⁷⁴	10.89	TNF MIR21 MIR199A1 MIR155 MIR126 IL6
23	Overview of nanoparticle effects ⁷⁴	10.82	TNF IL6 CRP
24	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.7	IL6 IL1B
25	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.26	TNF IL6

Sources

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.96	CRP IL1B IL6 MIR125A MIR126 MIR140
2	RISC complex	GO:0016442	9.66	MIR223 MIR210 MIR21 MIR199A1 MIR17 MIR155
3	extracellular vesicle	GO:1903561	9.55	MIR34A MIR21 MIR17 MIR126 MIR125A

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 44)

#	Name	GO ID	Score	Top Affiliating Genes
1	defense response to Gram-positive bacterium	GO:0050830	10.28	CRP IL1B IL6 TNF
2	acute-phase response	GO:0006953	10.15	SERPINA3 IL6 CRP
3	positive regulation of inflammatory response	GO:0050729	10.1	TNF MIR21 MIR126 IL1B
4	positive regulation of chemokine production	GO:0032722	10.09	TNF IL6 IL1B
5	negative regulation of neurogenesis	GO:0050768	10.09	TNF IL6 IL1B
6	positive regulation of glial cell proliferation	GO:0060252	10.08	IL1B IL6 TNF
7	positive regulation of angiogenesis	GO:0045766	10.08	MIR210 MIR21 MIR199A1 MIR126 IL1B
8	positive regulation of protein kinase B signaling	GO:0051897	10.06	TNF MIR21 MIR199A1 MIR126
9	positive regulation of gene expression	GO:0010628	10.03	CRP IL1B IL6 MIR125A MIR140 MIR146A
10	negative regulation of gene expression	GO:0010629	10.02	MIR125A MIR140 MIR146A MIR155 MIR17 MIR199A1
11	negative regulation of lipid storage	GO:0010888	10.01	TNF IL6 CRP
12	vascular endothelial growth factor production	GO:0010573	10	TNF IL6 IL1B
13	cellular response to amyloid-beta	GO:1904646	9.99	TNF MIR146A MIR140
14	negative regulation of interleukin-6 production	GO:0032715	9.99	TNF MIR146A MIR140 MIR125A
15	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.99	TNF MIR21 MIR17 IL6
16	positive regulation of fever generation	GO:0031622	9.98	TNF IL1B
17	miRNA-mediated gene silencing	GO:0035195	9.98	MIR34A MIR223 MIR210 MIR21 MIR199A1 MIR17
18	positive regulation of leukocyte adhesion to vascular endothelial cell	GO:1904996	9.97	TNF MIR21 IL6
19	cellular response to hypoxia	GO:0071456	9.97	MIR34A MIR17 MIR146A MIR140 MIR126
20	negative regulation of endothelial cell proliferation	GO:0001937	9.96	TNF MIR21 MIR146A
21	negative regulation of inflammatory response	GO:0050728	9.96	MIR126 MIR142 MIR146A MIR199A1 MIR223
22	cellular response to lipopolysaccharide	GO:0071222	9.96	TNF MIR223 MIR21 MIR17 MIR146A MIR140
23	sequestering of triglyceride	GO:0030730	9.95	IL1B TNF
24	positive regulation of vascular associated smooth muscle cell proliferation	GO:1904707	9.95	TNF MIR21 MIR17 MIR146A
25	negative regulation of angiogenesis	GO:0016525	9.93	MIR34A MIR21 MIR146A MIR125A
26	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.92	TNF IL1B
27	positive regulation of neuroinflammatory response	GO:0150078	9.91	TNF MIR142 IL6 IL1B
28	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.87	MIR21 IL6
29	negative regulation of bicellular tight junction assembly	GO:1903347	9.86	TNF MIR142
30	negative regulation of vascular associated smooth muscle cell proliferation	GO:1904706	9.84	MIR34A MIR223 MIR140
31	negative regulation of NIK/NF-kappaB signaling	GO:1901223	9.83	MIR223 MIR21 MIR146A
32	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	9.83	MIR210 MIR21 MIR17 MIR146A MIR126
33	negative regulation of cytokine production involved in inflammatory response	GO:1900016	9.8	MIR146A MIR140 MIR125A
34	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GO:1903589	9.76	MIR21 MIR146A MIR126
35	negative regulation of vascular associated smooth muscle cell migration	GO:1904753	9.76	MIR34A MIR223 MIR21 MIR140
36	miRNA-mediated gene silencing by mRNA destabilization	GO:0035279	9.71	MIR223 MIR210 MIR146A MIR140
37	positive regulation of cardiac muscle hypertrophy in response to stress	GO:1903244	9.68	MIR199A1 MIR17
38	positive regulation of metalloendopeptidase activity	GO:1904685	9.67	MIR21 MIR17
39	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.67	MIR17 MIR21 MIR210
40	negative regulation of intracellular signal transduction	GO:1902532	9.65	MIR146A MIR34A
41	negative regulation of BMP secretion	GO:2001285	9.65	MIR210 MIR17 MIR140
42	negative regulation of matrix metallopeptidase secretion	GO:1904465	9.64	MIR146A MIR199A1
43	negative regulation of leukocyte adhesion to vascular endothelial cell	GO:1904995	9.64	MIR125A MIR146A
44	negative regulation of vascular endothelial growth factor production	GO:1904046	9.1	MIR34A MIR199A1 MIR17 MIR146A MIR140 MIR125A

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA base-pairing translational repressor activity	GO:1903231	9.73	MIR34A MIR223 MIR210 MIR21 MIR199A1 MIR17
2	mRNA 3'-UTR binding	GO:0003730	9.4	MIR34A MIR223 MIR210 MIR21 MIR199A1 MIR17