MCID: BNN003
MIFTS: 48

Bone Inflammation Disease

Categories: Bone diseases
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Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease 11 14
Osteitis 11 43 14 71
Inflammatory Disorder of Bone 11
Bone Inflammatory Disease 11

Classifications:



External Ids:

Disease Ontology 11 DOID:3342
MeSH 43 D010000
SNOMED-CT 68 274144001
UMLS 71 C0029400

Summaries for Bone Inflammation Disease

Disease Ontology: 11 A bone disease that results in inflammation of the located in bone.

MalaCards based summary: Bone Inflammation Disease, also known as osteitis, is related to sapho syndrome and alveolar periostitis. An important gene associated with Bone Inflammation Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Toll-like receptor signaling pathway and Sudden infant death syndrome (SIDS) susceptibility pathways. The drugs Chlorhexidine and Zoledronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and prostate, and related phenotypes are immune system and hematopoietic system

Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1102)
# Related Disease Score Top Affiliating Genes
1 sapho syndrome 33.2 TNF CRP CCR6
2 alveolar periostitis 32.6 TNF IL6 CRP
3 spondyloarthropathy 1 32.4 TNF IL6 IL1B ICOSLG CRP CCR6
4 osteomyelitis 32.4 TNF IL6 IL1B CRP
5 synovitis 32.0 TNF IL6 IL1B CRP
6 acne 32.0 TNF IL6 IL1B CRP
7 pustulosis of palm and sole 31.8 TNF SERPINA3 CRP CCR6
8 chronic recurrent multifocal osteomyelitis 31.8 TNF IL6 IL1B CRP
9 common cold 31.6 TNF IL6 IL1B ICOSLG CRP CCR6
10 spondylitis 31.6 TNF IL6 IL1B CRP CCR6
11 syphilis 31.5 TNF MIR142 CRP CCR6
12 bone disease 31.4 TNF SERPINA3 MIR34A MIR223 MIR210 MIR21
13 back pain 31.3 IL6 IL1B CRP
14 rheumatoid arthritis 31.3 TNF SERPINA3 MIR155 MIR146A IL6 IL1B
15 periostitis 31.2 TNF IL1B CRP
16 septic arthritis 31.2 TNF IL6 IL1B CRP
17 typhoid fever 31.1 TNF IL6 IL1B CRP CCR6
18 psoriatic arthritis 31.1 TNF MIR146A IL6 IL1B ICOSLG CRP
19 spondyloarthropathy 31.0 TNF IL6 IL1B ICOSLG CRP CCR6
20 tenosynovitis 31.0 TNF IL6 IL1B CRP
21 osteoporosis 31.0 TNF MIR210 MIR21 MIR140 IL6 IL1B
22 enthesopathy 31.0 TNF CRP CCR6
23 pulpitis 31.0 TNF IL6 IL1B
24 chronic kidney disease 31.0 TNF MIR21 MIR126 IL6 IL1B CRP
25 meningitis 30.9 TNF IL6 IL1B CRP
26 sarcoidosis 1 30.9 TNF SERPINA3 MIR155 IL6 IL1B ICOSLG
27 brucellosis 30.9 TNF IL6 CRP
28 leprosy 3 30.9 TNF SERPINA3 IL6 IL1B CCR6
29 pyoderma 30.9 TNF IL1B CRP CCR6
30 paratyphoid fever 30.8 TNF IL1B CRP
31 kidney disease 30.8 TNF MIR21 MIR199A1 IL6 IL1B CRP
32 periodontitis 30.8 TNF SERPINA3 MIR21 MIR17 MIR142 MIR125A
33 osteoarthritis 30.8 TNF MIR140 IL6 IL1B CRP
34 dermatitis 30.8 TNF IL6 IL1B CCR6
35 histiocytosis 30.8 TNF SERPINA3 CCR6
36 pyoderma gangrenosum 30.8 TNF IL1B CCR6
37 ankylosis 30.8 TNF CRP CCR6
38 arthropathy 30.8 TNF IL6 IL1B CRP CCR6
39 langerhans cell histiocytosis 30.8 TNF SERPINA3 ICOSLG CCR6
40 exanthem 30.8 TNF IL6 IL1B ICOSLG H2AC18 CRP
41 aspergillosis 30.8 TNF IL6 IL1B CCR6
42 paine syndrome 30.8 TNF IL6 IL1B H2AC18
43 labyrinthitis 30.8 TNF IL1B CRP
44 tonsillitis 30.8 TNF IL6 IL1B
45 toxic shock syndrome 30.7 TNF IL6 IL1B CRP
46 sickle cell anemia 30.7 TNF IL6 H2AC18 CRP
47 tetanus 30.7 TNF IL6 IL1B CRP
48 rhinitis 30.7 TNF IL6 IL1B ICOSLG
49 bone cancer 30.7 SERPINA3 MIR34A MIR223 MIR210 MIR21 MIR199A1
50 reactive arthritis 30.7 TNF CRP CCR6

Graphical network of the top 20 diseases related to Bone Inflammation Disease:



Diseases related to Bone Inflammation Disease

Symptoms & Phenotypes for Bone Inflammation Disease

MGI Mouse Phenotypes related to Bone Inflammation Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.83 CCR6 CRP ICOSLG IL1B IL6 MIR125A
2 hematopoietic system MP:0005397 9.47 CCR6 ICOSLG IL1B IL6 MIR125A MIR126

Drugs & Therapeutics for Bone Inflammation Disease

Drugs for Bone Inflammation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 73)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved, Withdrawn Phase 4 55-56-1 2713 9552079
2
Zoledronic acid Approved Phase 4 118072-93-8 68740
3
Alendronic acid Approved Phase 4 121268-17-5, 66376-36-1 2088
4
Pamidronic acid Approved Phase 4 40391-99-9 4674
5
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 4 67-97-0, 1406-16-2 5280795 10883523
6 Calcium, Dietary Phase 4
7 Chlorhexidine gluconate Phase 4
8 Vitamins Phase 4
9 Trace Elements Phase 4
10 Calciferol Phase 4
11 Micronutrients Phase 4
12 Diphosphonates Phase 4
13
Calcium Nutraceutical Phase 4 7440-70-2 271
14
Risedronic acid Approved, Investigational Phase 3 105462-24-6 5245
15
Etidronic acid Approved Phase 3 2809-21-4, 7414-83-7 3305
16 Antibiotics, Antitubercular Phase 3
17 Anti-Bacterial Agents Phase 3
18 Anti-Infective Agents Phase 3
19 Hormones Phase 3
20 calcium channel blockers Phase 3
21
Hydrogen peroxide Approved, Vet_approved Phase 2 7722-84-1 784
22
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3 3680
23
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 3003 5743
24
Octenidine Investigational Phase 2 71251-02-0
25 Pharmaceutical Solutions Phase 2
26 Anti-Inflammatory Agents Phase 2
27 Gastrointestinal Agents Phase 2
28 Antineoplastic Agents, Hormonal Phase 2
29 Dexamethasone 21-phosphate Phase 2
30 Hormone Antagonists Phase 2
31 Antiemetics Phase 2
32 HIV Protease Inhibitors Phase 2
33 glucocorticoids Phase 2
34 BB 1101 Phase 2
35
protease inhibitors Phase 2
36
Acetylsalicylic acid Approved, Vet_approved 50-78-2 2244
37
Tetracycline Approved, Vet_approved, Withdrawn 60-54-8 5353990
38
Menthol Approved, Experimental 1490-04-6, 2216-51-5, 15356-60-2 1254 16666 165675
39
Sorbitol Approved, Investigational 69-65-8, 50-70-4 453 6251 5780
40
Peppermint oil Approved, Investigational 8006-90-4
41
Peppermint Approved
42
Silicon Approved, Investigational 7440-21-3 4082203
43
Tocopherol Approved, Investigational 1406-66-2
44
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
45
Eugenol Approved 97-53-0 3314
46
Infliximab Approved 170277-31-3
47
DL-alpha-Tocopherol Approved, Experimental, Investigational, Nutraceutical, Vet_approved 59-02-9, 10191-41-0 2116 14985
48
Ascorbic acid Approved, Nutraceutical 50-81-7 54676860 54670067 5785
49
Tocotrienol Investigational 6829-55-6 9929901
50 Analgesics

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Efficacy of DC071 Mouthwash (0.2% Chlorhexidine Digluconate) in Peri-surgical Care for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
2 A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China Completed NCT00774020 Phase 4 Zoledronic acid
3 An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies Completed NCT00740129 Phase 4 Zoledronic Acid
4 Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation Completed NCT00668200 Phase 4 Reclast (ZOL446, zoledronic acid)
5 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4 Alendronate;Pamidronate
6 Open Label Study to Describe the Effect of Tocilizumab in Combination With MTX in the Evolution of Articular Damage (Synovitis/Osteitis and Erosions) Evaluated by MRI in the Hand of Patients With Moderate to Severe Rheumatoid Arthritis (RA) and Inadequate Response to Non-biological DMARDs Withdrawn NCT01878318 Phase 4 methotrexate;tocilizumab [RoActemra/Actemra]
7 Antibiotic Efficacy in Third Molar Surgery Completed NCT00118820 Phase 3 IV Preoperative antibiotic or placebo
8 A 6-Month, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Alendronate 280-mg Oral Buffered Solution Once Weekly in Patients With Paget's Disease of Bone Completed NCT00480662 Phase 3 alendronate
9 Randomized, Double-blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observational Period Completed NCT00051636 Phase 3 Zoledronic Acid;Risedronate;Placebo to Risedronate;Placebo to Zoledronic Acid
10 Randomized, Double-Blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observation Period Completed NCT00103740 Phase 3 zoledronic acid;placebo to zoledronic acid;Risedronate;Placebo to risedronate;Calcium and vitamin D supplements
11 Multi-centre, Open-label, First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro Completed NCT04091399 Phase 2 Stamatological tamponade Contipro
12 Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial Suspended NCT03606980 Phase 2 Dexamethasone Sodium Phosphate
13 Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders Unknown status NCT00403598
14 Characterizing Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) With 68Ga-FAPI PET/CT Unknown status NCT04596462 Early Phase 1 68Ga-FAPI
15 Allogenic Vascularized Knee and Femur Transplantation Clinical Evaluation Unknown status NCT01133145
16 Evaluation of Platelet Rich Fibrin Use in the Treatment of Dry Socket. Unknown status NCT04476121 Nipas application
17 Comparison of Three Treatments for Lower Extremity Apophysitis Unknown status NCT01826071
18 Effect of Concentrated Growth Factors on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Study Completed NCT04151147
19 Pressure Sore-related Osteitis Treated by Flap Coverage and Short Antibiotic Regimen Completed NCT03964818
20 Clinical Investigation of the Efficacy of CGF (Concentrated Growth Factor) and Ozone in the Treatment of Alveolar Osteitis Completed NCT04507009
21 A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery Completed NCT03494972 Tetracyclin ointment
22 Post-transition Clinical and Socio-professional Future in Adult Patients With Recurrent Multifocal Chronic Osteitis Completed NCT05103137
23 Effect of NBF Gingival Gel Application in Controlling Post-surgical Complications After Impacted Lower Third Molar Surgery Completed NCT03641482 NBF
24 Genetic Study of Families Affected by Paget's Disease of Bone Completed NCT00747994
25 Sodium Risedronate 17.5 mg Tablets Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) - 48-week Surveillance - Completed NCT02106455 Sodium risedronate
26 Use of 18F-Fluoride Positron Emission Tomography in the Assessment and Evaluation of Therapy in Monostotic Paget's Disease of Bone Completed NCT00306046 Bisphosphonate treatment
27 Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial Completed NCT03960086
28 A Clinical Investigation of the Efficacy of Platelet Rich Fibrin (Bio-PRF) Compared to Alveogyl in the Treatment of Alveolar Osteitis Recruiting NCT05615272 Alveogyl
29 Effect of Hyaluronic Acid on the Therapy of Alveolar Osteitis - A Double-blind, Randomized Controlled Clinical Trial Recruiting NCT04853589
30 Bone Flap Osteomyelitis Following Craniectomy : Retrospective Evaluation of Clinical Presentation, Microbiological Diagnosis and Management Recruiting NCT05367713
31 Prediction of IBD Disease Activity in Individual Patients Based on PROMs and Clinical Data Recruiting NCT05578768
32 Infliximab Proactive Drug Monitoring in the Pediatric IBD Population Recruiting NCT04921670
33 Genetic Analysis to Predict the Development of Paget's Disease Recruiting NCT05309954
34 Characterization of Familial Myopathy and Paget Disease of Bone Recruiting NCT01353430
35 Investigation of Pathophysiology of Angiogenesis and Osteogenesis in Paget's Disease of Bone Active, not recruiting NCT02802384
36 Management of Lower Limb Apophysitis: A Cross-sectional Study on Long-term Impact on Health Status Enrolling by invitation NCT04313621

Search NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

Genetic Tests for Bone Inflammation Disease

Anatomical Context for Bone Inflammation Disease

Organs/tissues related to Bone Inflammation Disease:

FMA: Bone
MalaCards : Bone, Bone Marrow, Prostate, Spinal Cord, Skin, Kidney, Thyroid

Publications for Bone Inflammation Disease

Articles related to Bone Inflammation Disease:

(show top 50) (show all 4815)
# Title Authors PMID Year
1
Presence of axial spondyloarthritis associated sacroiliitis and structural changes on MR enterography: A direct comparison with sacroiliac joint MRI. 62
36152432 2022
2
Survey of the treatment outcome of patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis. 62
35983683 2022
3
Clinical and Epidemiologic Characteristics and Therapeutic Management of Patients with Vibrio Infections, Bay of Biscay, France, 2001-2019. 62
36418019 2022
4
The "Hand as Foot" teaching method in whole-body bone scintigraphy of synovitis-acne-pustulosishyperostosis-osteitis syndrome. 62
35773110 2022
5
A Rare Cause of Postpartum Back Ache: Osteitis Condensans Ilii. 62
36457436 2022
6
Regional antibiotic perfusion through the lateral saphenous vein in two horses with septic calcaneal osteitis. 62
36418075 2022
7
Intra-articular Soft Tissue Pathology of the Postpartum Hip: A Systematic Review. 62
36350530 2022
8
Towards a simplified fluid-sensitive MRI protocol in small joints of the hand in early arthritis patients: reliability between modified Dixon and regular Gadolinium enhanced TSE fat saturated MRI-sequences. 62
36441238 2022
9
Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome associated with pyoderma gangrenosum: report of two patients. 62
36345566 2022
10
[Emergency free flap in reconstruction of the lower limb: About 23 cases over 11 years]. 62
36463023 2022
11
Implementation of the OMERACT Psoriatic Arthritis Magnetic Resonance Imaging Scoring System in a randomized phase IIb study of abatacept in psoriatic arthritis. 62
35137002 2022
12
Coincidence of pachydermoperiostosis and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, a causal or casual association? 62
35938529 2022
13
Viral infections in orthopedics: A systematic review and classification proposal. 62
36439372 2022
14
Malignant external otitis complicated by spinal cord compression: Case report. 62
36389183 2022
15
Standardized reporting and quantification of whole-body MRI findings in children with chronic non-bacterial osteomyelitis treated with pamidronate. 62
36183086 2022
16
Value of a lateral inferior pedicle flap in Draf IIb for recurrent frontal sinus diseases: a prospective study. 62
35220482 2022
17
How Has Molecular Biology Enhanced Our Undertaking of axSpA and Its Management. 62
36308677 2022
18
Intermetatarsal Bursitis, a Novel Feature of Juxtaarticular Inflammation in Early Rheumatoid Arthritis Related to Clinical Signs: Results of a Longitudinal Magnetic Resonance Imaging Study. 62
33973415 2022
19
Work productivity and activity in patients with SAPHO syndrome: a cross-sectional observational study. 62
36271426 2022
20
Successful treatment of nail involvement using leflunomide in a patient with synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. 62
36309922 2022
21
Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata. 62
36224598 2022
22
The efficacy of minocycline hydrochloride ointment versus iodoform gauze for alveolar osteitis: A prospective cohort study. 62
36258229 2022
23
Hemostatic Alginate/Nano-Hydroxyapatite Composite Aerogel Loaded with Tranexamic Acid for the Potential Protection against Alveolar Osteitis. 62
36297689 2022
24
Is Chitosan Dental Dressing Better Than Cotton Gauze in Achieving Hemostasis in Patients on Antithrombotics? 62
36403660 2022
25
Performance of an MRI scoring system for inflammation of joints and entheses in peripheral SpA: post-hoc analysis of the CRESPA trial. 62
36200875 2022
26
Hand and foot MRI in contemporary undifferentiated arthritis: in which patients is MRI valuable to detect rheumatoid arthritis early? A large prospective study. 62
35022703 2022
27
Hip Range of Motion and Strength in Male Athletes with Stage 1 Osteitis Pubis: A Cross-Sectional and Correlational Study. 62
36232123 2022
28
Efficacy and safety of guselkumab and adalimumab for pustulotic arthro-osteitis and their impact on peripheral blood immunophenotypes. 62
36303202 2022
29
Athletic Osteitis Pubis Detected on 18 F-FDG PET/CT. 62
35452006 2022
30
Tympanic bullae ultrasonography is feasible in nonsedated healthy rabbits (Oryctolagus cuniculus). 62
36170214 2022
31
Metallosis after using distal fibular locking plate for lateral malleolar fractures: a retrospective study. 62
33646355 2022
32
Diagnostic Accuracy of Standalone T2 Dixon Sequence Compared with Conventional MRI in Sacroiliitis. 62
36177276 2022
33
Effectiveness of Honey in the Treatment and Prevention of Alveolar Osteitis: Systematic Review and Meta-analysis. 62
36274888 2022
34
Occult Pulmonary Neuroendocrine Tumor Causing Severe Hyperparathyroidism: Diagnostic Challenges and Clinical Outcomes. 62
36189140 2022
35
Local interventions for the management of alveolar osteitis (dry socket). 62
36156769 2022
36
Synovitis-acne-pustulosis-hyperostosis-osteitis Syndrome with Bilateral Pleural Effusion. 62
35135914 2022
37
Does SAPHO syndrome exist in dermatology? 62
35462435 2022
38
Analysis of metabolites of fungal balls in the paranasal sinuses. 62
36100882 2022
39
Radiosurgery for Benign Vertebral Body Hemangiomas of the Spine: A Systematic Review and Meta-Analysis. 62
35378316 2022
40
Characteristics and incidence of vaccine adverse events after Bacille Calmette-Guérin vaccination: A national surveillance study in Japan from 2013 to 2017. 62
35690499 2022
41
Osteitis Condensans Ilii: A Case Series. 62
36148199 2022
42
Acetabular fixation in total hip arthroplasty in the previously irradiated pelvis: a review of basic science and clinical outcomes. 62
35984490 2022
43
Clinical characteristics of pustulotic arthro-osteitis in Korea. 62
35510638 2022
44
Radiographic aspects in individuals infected by human T-lymphotropic virus type 1 (HTLV-1) with joint pain. 62
35945643 2022
45
Efficacy of tranexamic acid in prevention of alveolar osteitis following surgical removal of impacted mandibular third molar. 62
36393943 2022
46
Plate-associated localized osteitis in mini-pig by biofilm-forming Methicillin-resistant Staphylococcus aureus (MRSA): establishment of a novel experimental model. 62
35201371 2022
47
The challenges in diagnosis and management of osteitis pubis: An algorithm based on current evidence. 62
35783593 2022
48
Pustulotic arthro-osteitis (Sonozaky syndrome). 62
35156627 2022
49
Sclerosis of the clavicle--A challenging diagnosis. 62
35570861 2022
50
Effect of initiating biologics compared to intensifying conventional DMARDs on clinical and MRI outcomes in established rheumatoid arthritis patients in clinical remission: Secondary analyses of the IMAGINE-RA trial. 62
34474649 2022

Variations for Bone Inflammation Disease

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.74 TNF MIR155 MIR146A IL6 IL1B
2 12.03 TNF MIR210 IL6 IL1B
3
Show member pathways
11.98 MIR140 MIR199A1 MIR21 TNF
4 11.69 TNF IL1B CCR6
5 11.66 TNF IL6 IL1B
6 11.64 TNF IL6 IL1B
7 11.57 IL1B IL6 TNF
8
Show member pathways
11.56 IL1B IL6 TNF
9 11.54 TNF IL6 IL1B
10
Show member pathways
11.52 MIR155 MIR17 MIR199A1 MIR223
11 11.48 MIR34A MIR155 IL6
12 11.41 TNF IL6 ICOSLG CRP
13 11.4 TNF IL6 IL1B
14 11.37 TNF IL6 IL1B
15 11.28 MIR223 MIR210 MIR21 MIR17
16 11.21 TNF IL6 IL1B
17 11.16 TNF IL6 IL1B
18 11.11 TNF IL6 IL1B
19 11.07 TNF IL6 IL1B
20 11.03 TNF IL6 IL1B
21 10.94 MIR34A MIR210 MIR21 MIR146A
22 10.89 TNF MIR21 MIR199A1 MIR155 MIR126 IL6
23 10.82 TNF IL6 CRP
24 10.7 IL6 IL1B
25
Show member pathways
10.26 TNF IL6

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.96 CRP IL1B IL6 MIR125A MIR126 MIR140
2 RISC complex GO:0016442 9.66 MIR223 MIR210 MIR21 MIR199A1 MIR17 MIR155
3 extracellular vesicle GO:1903561 9.55 MIR34A MIR21 MIR17 MIR126 MIR125A

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 44)
# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 10.28 CRP IL1B IL6 TNF
2 acute-phase response GO:0006953 10.15 SERPINA3 IL6 CRP
3 positive regulation of inflammatory response GO:0050729 10.1 TNF MIR21 MIR126 IL1B
4 positive regulation of chemokine production GO:0032722 10.09 TNF IL6 IL1B
5 negative regulation of neurogenesis GO:0050768 10.09 TNF IL6 IL1B
6 positive regulation of glial cell proliferation GO:0060252 10.08 IL1B IL6 TNF
7 positive regulation of angiogenesis GO:0045766 10.08 MIR210 MIR21 MIR199A1 MIR126 IL1B
8 positive regulation of protein kinase B signaling GO:0051897 10.06 TNF MIR21 MIR199A1 MIR126
9 positive regulation of gene expression GO:0010628 10.03 CRP IL1B IL6 MIR125A MIR140 MIR146A
10 negative regulation of gene expression GO:0010629 10.02 MIR125A MIR140 MIR146A MIR155 MIR17 MIR199A1
11 negative regulation of lipid storage GO:0010888 10.01 TNF IL6 CRP
12 vascular endothelial growth factor production GO:0010573 10 TNF IL6 IL1B
13 cellular response to amyloid-beta GO:1904646 9.99 TNF MIR146A MIR140
14 negative regulation of interleukin-6 production GO:0032715 9.99 TNF MIR146A MIR140 MIR125A
15 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.99 TNF MIR21 MIR17 IL6
16 positive regulation of fever generation GO:0031622 9.98 TNF IL1B
17 miRNA-mediated gene silencing GO:0035195 9.98 MIR34A MIR223 MIR210 MIR21 MIR199A1 MIR17
18 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.97 TNF MIR21 IL6
19 cellular response to hypoxia GO:0071456 9.97 MIR34A MIR17 MIR146A MIR140 MIR126
20 negative regulation of endothelial cell proliferation GO:0001937 9.96 TNF MIR21 MIR146A
21 negative regulation of inflammatory response GO:0050728 9.96 MIR126 MIR142 MIR146A MIR199A1 MIR223
22 cellular response to lipopolysaccharide GO:0071222 9.96 TNF MIR223 MIR21 MIR17 MIR146A MIR140
23 sequestering of triglyceride GO:0030730 9.95 IL1B TNF
24 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 9.95 TNF MIR21 MIR17 MIR146A
25 negative regulation of angiogenesis GO:0016525 9.93 MIR34A MIR21 MIR146A MIR125A
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.92 TNF IL1B
27 positive regulation of neuroinflammatory response GO:0150078 9.91 TNF MIR142 IL6 IL1B
28 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.87 MIR21 IL6
29 negative regulation of bicellular tight junction assembly GO:1903347 9.86 TNF MIR142
30 negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 9.84 MIR34A MIR223 MIR140
31 negative regulation of NIK/NF-kappaB signaling GO:1901223 9.83 MIR223 MIR21 MIR146A
32 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.83 MIR210 MIR21 MIR17 MIR146A MIR126
33 negative regulation of cytokine production involved in inflammatory response GO:1900016 9.8 MIR146A MIR140 MIR125A
34 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.76 MIR21 MIR146A MIR126
35 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.76 MIR34A MIR223 MIR21 MIR140
36 miRNA-mediated gene silencing by mRNA destabilization GO:0035279 9.71 MIR223 MIR210 MIR146A MIR140
37 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.68 MIR199A1 MIR17
38 positive regulation of metalloendopeptidase activity GO:1904685 9.67 MIR21 MIR17
39 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.67 MIR17 MIR21 MIR210
40 negative regulation of intracellular signal transduction GO:1902532 9.65 MIR146A MIR34A
41 negative regulation of BMP secretion GO:2001285 9.65 MIR210 MIR17 MIR140
42 negative regulation of matrix metallopeptidase secretion GO:1904465 9.64 MIR146A MIR199A1
43 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.64 MIR125A MIR146A
44 negative regulation of vascular endothelial growth factor production GO:1904046 9.1 MIR34A MIR199A1 MIR17 MIR146A MIR140 MIR125A

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA base-pairing translational repressor activity GO:1903231 9.73 MIR34A MIR223 MIR210 MIR21 MIR199A1 MIR17
2 mRNA 3'-UTR binding GO:0003730 9.4 MIR34A MIR223 MIR210 MIR21 MIR199A1 MIR17

Sources for Bone Inflammation Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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