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MCID: BNN003
MIFTS: 48

Bone Inflammation Disease

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Bone Inflammation Disease

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MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease 12 15
Osteitis 12 43 15 71
Inflammatory Disorder of Bone 12
Bone Inflammatory Disease 12

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3342
MeSH 43 D010000
SNOMED-CT 67 274144001
UMLS 71 C0029400
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Summaries for Bone Inflammation Disease

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Disease Ontology : 12 A bone disease that results in inflammation of the located in bone.

MalaCards based summary : Bone Inflammation Disease, also known as osteitis, is related to sapho syndrome and osteomyelitis. An important gene associated with Bone Inflammation Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Alendronate and Zoledronic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and skin.

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Related Diseases for Bone Inflammation Disease

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Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 962)
# Related Disease Score Top Affiliating Genes
1 sapho syndrome 34.0 TNFRSF1B TNF MRAP
2 osteomyelitis 32.8 TNF IL6 IL1B
3 spondyloarthropathy 1 32.7 TNFRSF1B TNF MRAP IL17A ICOSLG CRP
4 arthritis 32.7 TNFRSF1B TNF IL6 IL1B IL17A CRP
5 synovitis 32.4 TNF IL6 IL1B IL17A CRP ACAN
6 spondylitis 32.0 TNFRSF1B TNF IL6 IL17A CRP CCR6
7 bone disease 31.9 TNF SERPINA3 IL6 IL1B IL17A ICOSLG
8 syphilis 31.9 TNF SERPINA3 MRAP IL6 IL17A CRP
9 chronic recurrent multifocal osteomyelitis 31.8 TNF MRAP IL6 IL1B CRP
10 bone resorption disease 31.8 TNF SERPINA3 MIR142 MIR140 IL6 IL1B
11 enthesopathy 31.7 TNFRSF1B TNF MRAP CRP CCR6
12 spondyloarthropathy 31.6 TNF IL6 IL1B IL17A CCR6
13 pustulosis of palm and sole 31.6 TNFRSF1B TNF MRAP IL17A CRP CCR6
14 septic arthritis 31.6 TNF MRAP IL6 IL1B CRP
15 typhoid fever 31.5 TNF IL6 IL1B CRP CCR6
16 tenosynovitis 31.5 TNFRSF1B TNF MRAP IL6 CRP
17 psoriasis 31.5 TNFRSF1B TNF MIR21 MIR155 MIR146A MIR142
18 pulpitis 31.5 TNF IL6 IL1B CCR6
19 meningitis 31.5 TNF IL6 IL1B IL17A CRP
20 brucellosis 31.5 TNF IL6 IL17A CRP
21 psoriatic arthritis 31.4 TNFRSF1B TNF MIR146A IL6 IL1B IL17A
22 osteoarthritis 31.4 TNF IL6 IL1B IL17A CRP ACAN
23 osteoporosis 31.4 TNFRSF1B TNF MIR21 MIR140 IL6 IL1B
24 dermatitis 31.4 TNF IL6 IL1B IL17A CCR6
25 ankylosis 31.3 TNFRSF1B TNF MRAP IL17A CRP CCR6
26 pyoderma 31.3 TNFRSF1B TNF IL1B CRP CCR6
27 histiocytosis 31.3 TNF SERPINA3 IL17A CCR6
28 prostatitis 31.3 TNF SERPINA3 IL6 IL1B
29 leprosy 3 31.2 TNF IL6 IL1B IL17A CD4 CCR6
30 immune deficiency disease 31.2 TNF SERPINA3 IL6 ICOSLG H2AC18 CD4
31 periodontitis 31.2 TNF SERPINA3 MIR21 MIR146A IL6 IL1B
32 myeloma, multiple 31.2 TNF SERPINA3 MIR21 MIR142 MIR140 IL6
33 pyoderma gangrenosum 31.2 TNFRSF1B TNF CCR6
34 rheumatoid arthritis 31.2 TNFRSF1B TNF SERPINA3 MIR155 MIR146A IL6
35 myositis 31.1 TNF SERPINA3 IL6 IL1B IL17A ICOSLG
36 arthropathy 31.1 TNF IL6 IL1B CRP ACAN
37 pneumonia 31.1 TNFRSF1B TNF IL6 IL1B IL17A CRP
38 allergic hypersensitivity disease 31.1 TNF IL17A ICOSLG H2AC18 CD4 CCR6
39 orchitis 31.1 TNF IL6 IL1B H2AC18 CRP CD4
40 tonsillitis 31.1 TNF IL6 IL1B
41 lymphadenitis 31.1 TNF SERPINA3 IL1B ICOSLG CRP CD4
42 reactive arthritis 31.1 TNF IL6 IL1B IL17A CRP CCR6
43 appendicitis 31.1 TNF IL6 IL1B IL17A CRP
44 salmonellosis 31.1 TNF IL6 IL1B IL17A CD4 CCR6
45 rhinitis 31.1 TNF IL6 IL1B IL17A ICOSLG
46 granulomatosis with polyangiitis 31.1 TNFRSF1B TNF IL17A ICOSLG CRP CD4
47 otitis media 31.1 TNF IL6 IL1B IL17A CRP
48 amyloidosis 31.1 TNF SERPINA3 IL6 IL1B CRP
49 toxic shock syndrome 31.1 TNF IL6 IL1B CRP
50 exanthem 31.1 TNFRSF1B TNF IL6 IL1B ICOSLG H2AC18

Graphical network of the top 20 diseases related to Bone Inflammation Disease:



Diseases related to Bone Inflammation Disease
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Symptoms & Phenotypes for Bone Inflammation Disease

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Drugs & Therapeutics for Bone Inflammation Disease

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Drugs for Bone Inflammation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 4 66376-36-1, 121268-17-5 2088
2
Zoledronic Acid Approved Phase 4 118072-93-8 68740
3
Pamidronate Approved Phase 4 40391-99-9 4674
4
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
5
Adalimumab Approved Phase 4 331731-18-1 16219006
6
Abatacept Approved Phase 4 332348-12-6 10237
7
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
8 Trace Elements Phase 4
9 Micronutrients Phase 4
10 Vitamins Phase 4
11 Nutrients Phase 4
12 Calcium, Dietary Phase 4
13 Calciferol Phase 4
14 Diphosphonates Phase 4
15
Calcium Nutraceutical Phase 4 7440-70-2 271
16
Risedronate Approved, Investigational Phase 3 105462-24-6 5245
17
Etidronic acid Approved Phase 3 2809-21-4, 7414-83-7 3305
18 Antibiotics, Antitubercular Phase 3
19 calcium channel blockers Phase 3
20
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741
21
Hydrogen peroxide Approved, Vet_approved Phase 2 7722-84-1 784
22
Amoxicillin Approved, Vet_approved Phase 1, Phase 2 26787-78-0 33613
23
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
24
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
25
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
26
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
27
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
28
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
29
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
30 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
31 Octenidine Investigational Phase 2 71251-02-0
32
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
33 Anti-Bacterial Agents Phase 1, Phase 2
34 Anti-Infective Agents Phase 1, Phase 2
35 Anesthetics Phase 1, Phase 2
36 Pharmaceutical Solutions Phase 2
37 Hormones Phase 2
38 Anti-Inflammatory Agents Phase 2
39 Antineoplastic Agents, Hormonal Phase 2
40 Hormone Antagonists Phase 2
41
protease inhibitors Phase 2
42 Antiemetics Phase 2
43 HIV Protease Inhibitors Phase 2
44 Dexamethasone 21-phosphate Phase 2
45 Gastrointestinal Agents Phase 2
46 BB 1101 Phase 2
47 glucocorticoids Phase 2
48 Methylprednisolone Acetate Phase 2
49 Neuroprotective Agents Phase 2
50 Protective Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Efficacy of DC071 Mouthwash (0.2% Chlorhexidine Digluconate) in Peri-surgical Care for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
2 A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China Completed NCT00774020 Phase 4 Zoledronic acid
3 An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies Completed NCT00740129 Phase 4 Zoledronic Acid
4 Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation Completed NCT00668200 Phase 4 Reclast (ZOL446, zoledronic acid)
5 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4 Alendronate;Pamidronate
6 The Study of Efficacy and Safety of Calcium Sensing Receptor in Chronic Dialysis Patients Completed NCT02056730 Phase 4 calcium sensing receptor agonist
7 Can Bone Erosions Heal in Adalimumab (Humira) Treated Rheumatoid Arthritis Patients. An Imaging Study Using Computed Tomography and Magnetic Resonance Imaging. Completed NCT00696059 Phase 4 Adalimumab (Humira)
8 Abatacept Bone Effects in Psoriatic Arthritis With Bone Biomarkers - ABEPSA _ BB Recruiting NCT04106804 Phase 4 Abatacept 125 MG/ML
9 Open Label Study to Describe the Effect of Tocilizumab in Combination With MTX in the Evolution of Articular Damage (Synovitis/Osteitis and Erosions) Evaluated by MRI in the Hand of Patients With Moderate to Severe Rheumatoid Arthritis (RA) and Inadequate Response to Non-biological DMARDs Withdrawn NCT01878318 Phase 4 methotrexate;tocilizumab [RoActemra/Actemra]
10 A 6-Month, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Alendronate 280-mg Oral Buffered Solution Once Weekly in Patients With Paget's Disease of Bone Completed NCT00480662 Phase 3 alendronate
11 Randomized, Double-Blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observation Period Completed NCT00103740 Phase 3 zoledronic acid;placebo to zoledronic acid;Risedronate;Placebo to risedronate;Calcium and vitamin D supplements
12 Randomized, Double-blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observational Period Completed NCT00051636 Phase 3 Zoledronic Acid;Risedronate;Placebo to Risedronate;Placebo to Zoledronic Acid
13 Antibiotic Efficacy in Third Molar Surgery Completed NCT00118820 Phase 3 IV Preoperative antibiotic or placebo
14 An Open-Label, Pilot Trial to Assess the Impact of Subcutaneous Abatacept in Rheumatoid Arthritis Assessing Inhibition of Structural Damage Determined by Low Field Extremity MRI (eMRI) and X-ray Completed NCT01333878 Phase 2, Phase 3
15 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate in a Randomised Placebo Controlled Trial Unknown status NCT02594878 Phase 2 Pamidronatdinatrium
16 The Influence of Intra-alveolar Application of Honey on Healing Following Molar Teeth Extraction: A Randomized Clinical Trial Unknown status NCT02678104 Phase 2 Chlorhexidine mouth wash;Intra-alveolar application of Manuka Honey
17 Multi-centre, Open-label, First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro Completed NCT04091399 Phase 2 Stamatological tamponade Contipro
18 Does a Single Dose of Systemic Antibiotics Prevent Postoperative Inflammatory Complications After Lower Third Molar Surgery? A Randomized Controlled Trial Completed NCT03130933 Phase 1, Phase 2 Amoxicillin 500 Mg
19 Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial Recruiting NCT03606980 Phase 2 Dexamethasone Sodium Phosphate
20 MRI Evaluation Assessing Synovitis to Address the Unmet Need for Reliable Endpoints in SLE Recruiting NCT03355482 Phase 2 Methylprednisolone;Placebos
21 A Phase IIB, Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy and Safety of Fostamatinib Disodium Monotherapy Compared With Placebo or Adalimumab Monotherapy in Patients With Active Rheumatoid Arthritis: Magnetic Resonance Imaging Sub-Study Terminated NCT02092961 Phase 2 Fostamatinib;Adalimumab;Placebo of Fostamatinib;Placebo of Adalimumab
22 A Human Pilot Study to Quantify BCG From the BCG Vaccination Site, and to More Fully Characterise the Immune Response to BCG Completed NCT00653627 Phase 1
23 Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders Unknown status NCT00403598
24 Allogenic Vascularized Knee and Femur Transplantation Clinical Evaluation Unknown status NCT01133145
25 Comparison of Three Treatments for Lower Extremity Apophysitis Unknown status NCT01826071
26 Influence of Leukocyte- and Platelet Rich Fibrin (L-PRF) on the Outcomes of Impacted Mandibular Third Molar Removal Surgery: a Split-mouth Randomized Clinical Trial Unknown status NCT03357484
27 The Association of Serum Sclerostin Levels,Echocardiographic Parameters, Arteriovenous Fistula Thrombosis and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients Unknown status NCT01382966
28 To Evaluate the Efficacy of Aloe Vera Gel in Gingival Massaging and as an Adjunct to Scaling and Root Planing in Patients With Chronic Periodontitis Unknown status NCT03083535
29 Pressure Sore-related Osteitis Treated by Flap Coverage and Short Antibiotic Regimen Completed NCT03964818
30 Infection After Free Fibula Flap Reconstruction of the Mandible: a Retrospective Cohort Study Completed NCT04373278
31 A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery Completed NCT03494972 Tetracyclin ointment
32 Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial Completed NCT03960086
33 Effect of NBF Gingival Gel Application in Controlling Post-surgical Complications After Impacted Lower Third Molar Surgery Completed NCT03641482 NBF
34 Chronic Groin Pain and Sportsman Hernia of Athletes: Randomized Study Between Conservative Treatment and Laparoscopic Hernioplasty (TEP) Completed NCT00966589
35 Effect of Concentrated Growth Factors on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Study Completed NCT04151147
36 Management of Septic Non-union of the Tibia Using the "Induced Membrane" Technique Completed NCT03940638
37 Sodium Risedronate 17.5 mg Tablets Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) - 48-week Surveillance − Completed NCT02106455 Sodium risedronate
38 Effect of Probiotic Intervention With Lactobacillus Brevis KABP052 (CECT7480) and Lactobacillus Plantarum KABP051 (CECT7481) After Surgical Removal of Mandibular Third Molars: a Randomized, Controlled, Double-blinded Trial Completed NCT04203771 Ibuprofen
39 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Completed NCT00933296
40 Evaluation of Quality of Life in Patients Undergoing Parathyroidectomy Completed NCT00905866
41 A Study of Maintenance Therapy After Intravenous Maxacalcitol for Secondary Hyperparathyroidism Completed NCT00828347 1.0 μg/day Alfacalcidol;0.25 μg/day Alfacalcidol
42 Acutely Infected Teeth: To Extract Or Not To Extract? Completed NCT03485664
43 Does an MRI-guided Treatment Strategy Reduce Disease Activity and Progression in Patients With Rheumatoid Arthritis (RA): a Randomised Controlled Trial Completed NCT01656278
44 Clinical Outcome of Dental Extractions Among Renal Transplant Recipients Completed NCT02547753
45 Three-dimensional Measurements for Monitoring Wound Healing of Diabetic Foot Ulcers Completed NCT02423850
46 Use of 18F-Fluoride Positron Emission Tomography in the Assessment and Evaluation of Therapy in Monostotic Paget's Disease of Bone Completed NCT00306046 Bisphosphonate treatment
47 Total ExtraPeritoneal (TEP) Versus Open Minimal Suture Repair for Treatment of Sportsman's Hernia/Athletic Pubalgia: A Randomized Multi-center Trial. Completed NCT02297711
48 Genetic Study of Families Affected by Paget's Disease of Bone Completed NCT00747994
49 Evaluation Of Antiplaque Efficacy Of Licorice Extract Mouthrinse & Hypertonic Salt Solution And Their Comparison With Essential Oil & Chlorhexidine Mouthrinses-An Invitro & Invivo Study" Completed NCT03550651
50 The Influence of Concentrated Growth Factors (CGF) Application on Post-operative Complications. Recruiting NCT03992573

Search NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

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Genetic Tests for Bone Inflammation Disease

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Anatomical Context for Bone Inflammation Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Bone Inflammation Disease:

19
Bone

MalaCards organs/tissues related to Bone Inflammation Disease:

40
Bone, Prostate, Skin, Bone Marrow, Kidney, Neutrophil, Thyroid
Sources

Publications for Bone Inflammation Disease

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Articles related to Bone Inflammation Disease:

(show top 50) (show all 4424)
# Title Authors PMID Year
1
The prevalence of athletic pubalgia imaging findings on MRI in patients with femoroacetabular impingement. 61
32144449 2020
2
Osteitis Fibrosa Cystica Caused by Hyperparathyroidism Shown on 18F-NaF PET/CT. 61
32453081 2020
3
Toll-like receptor 4 polymorphisms were associated with low serum pro-inflammatory cytokines in BCG osteitis survivors. 61
31755594 2020
4
Osteitis condensans ilii: current knowledge and diagnostic approach. 61
32328707 2020
5
Improving the feasibility of MRI in clinically suspect arthralgia for prediction of rheumatoid arthritis by omitting scanning of the feet. 61
31566238 2020
6
Performance of a rapid two-sequence screening protocol for osteomyelitis of the foot. 61
31938864 2020
7
Long-lasting allergic patch test reactions to dental metal allergens in a patient with palmoplantar pustulosis and pustulotic arthro-osteitis. 61
32578251 2020
8
Management of a nonathlete with a traumatic groin strain and osteitis pubis using manual therapy and therapeutic exercise: A case report. 61
29979902 2020
9
The impact of asthma on quality of life and symptoms in patients with chronic rhinosinusitis. 61
32270714 2020
10
BCG Infection due to MPT64-Negative Strain: A Diagnostic Challenge. 61
32539913 2020
11
Demographic, clinical, and scintigraphic comparison of patients affected by palmoplantar pustulosis and severe acne: a retrospective study. 61
31953569 2020
12
A single cohort, open-label study of the efficacy of pamidronate for palmoplantar pustulosis in synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. 61
32573425 2020
13
Warfarin-induced impairment of bone material quality in a patient undergoing maintenance hemodialysis: A case report. 61
32569210 2020
14
Quantitative histomorphometric analysis of halved iliac crest bone biopsies yield comparable ROD diagnosis as full 7.5mm wide samples. 61
32485361 2020
15
RADIOLOGICAL MANIFESTATION OF BONE INVOLVEMENT IN PRIMARY HYPERPARATHYROIDISM: PREVALENCE AND CLINICAL SIGNIFICANCE IN A SOUTHERN EUROPEAN SERIES. 61
32407658 2020
16
Surgical removal versus retention for the management of asymptomatic disease-free impacted wisdom teeth. 61
32368796 2020
17
Bacillus Calmette-Guérin (BCG) vaccine safety surveillance in the Korea Adverse Event Reporting System using the tree-based scan statistic and conventional disproportionality-based algorithms. 61
32278521 2020
18
The use of plasma rich in growth factors (PRGF) in guided tissue regeneration and guided bone regeneration. A review of histological, immunohistochemical, histomorphometrical, radiological and clinical results in humans. 61
32376297 2020
19
Genetic variants in FBLIM1 gene do not contribute to SAPHO syndrome and chronic recurrent multifocal osteomyelitis in typical patient groups. 61
32397996 2020
20
Prevalence of anti-cyclic citrullinated peptide antibodies in patients with spondyloarthritis: A retrospective study. 61
32340503 2020
21
Orofacial manifestations of SAPHO syndrome: a systematic review of case reports. 61
32388746 2020
22
Clinical and imaging characteristics of osteitis condensans ilii as compared with axial spondyloarthritis. 61
32447391 2020
23
[Microsurgical soft tissue reconstruction in lower extremity osteitis]. 61
30352472 2020
24
The relation between physical joint examination and MRI-depicted inflammation of metatarsophalangeal joints in early arthritis. 61
32245515 2020
25
Alveolar Osteitis: A Review of Current Concepts. 61
32348729 2020
26
Pubic apophysitis in elite Australian Rules football players: MRI findings and the utility of VIBE sequences in evaluating athletes with groin pain. 61
32019672 2020
27
Prostatosymphyseal Fistula After Photoselective Vaporization of the Prostate: A Very Rare Complication of a Transurethral Surgery. 61
32431982 2020
28
A novel dual action monolithic thermosetting hydrogel loaded with lidocaine and metronidazole as a potential treatment for alveolar osteitis. 61
32001314 2020
29
The effect of triangular and reversed triangular flap designs to post third molar odontectomy complications (a pilot study). 61
32382381 2020
30
Comparison of Postoperative Outcomes Between Envelope and Triangular Flaps After Mandibular Third Molar Surgery: A Systematic Review and Meta-Analysis. 61
31883443 2020
31
SAPHO syndrome of the temporomandibular joint associated with trismus: a case report and review of the literature. 61
31414280 2020
32
Imaging features in patients with SAPHO/CRMO: a pictorial review. 61
32356235 2020
33
A retrospective study of bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: is it useful to repeat bone scintigraphy for disease assessment? 61
31858336 2020
34
Efficacy of tofacitinib in synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: a pilot study with clinical and MRI evaluation. 61
32332076 2020
35
Pediatric Synovitis, Acne, Pustulosis, Hyperostosis, Osteitis (SAPHO) Syndrome: Diagnostic Challenges and Treatment Approach. 61
32399329 2020
36
Risk factors for neo-osteogenesis in cystic fibrosis and non-cystic fibrosis chronic rhinosinusitis. 61
31856378 2020
37
Complete Fusion of Three Lumbar Vertebral Bodies in Ankylosing Spondylitis. 61
32395459 2020
38
Impact of Paranasal Sinus Surgery in Granulomatosis With Polyangiitis: A Longitudinal Computed Tomography Study. 61
32243590 2020
39
Characteristics of Japanese patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis: a multicenter study. 61
31985054 2020
40
Osteitis Fibrosa Cystica. 61
32160666 2020
41
Magnetic Resonance Imaging (MRI) Results Following Discontinuation of Methotrexate in Rheumatoid Arthritis Treated with Subcutaneous Tocilizumab: The COMP-ACT MRI Substudy. 61
31154414 2020
42
Comparison of primary and secondary closure with a buccal mucosal-advancement flap on postoperative course after mandibular impacted third molar surgery. 61
31729607 2020
43
Active inflammatory changes around the pubic symphysis in patients with axial spondyloarthritis: Magnetic resonance imaging characteristics and association with clinical factors. 61
31926385 2020
44
CT-guided transarticular biopsy of the sacroiliac joint: Technique and histomorphological results. A preliminary study. 61
31485679 2020
45
Evaluation of Neo-Osteogenesis in Eosinophilic Chronic Rhinosinusitis Using a Nasal Polyp Murine Model. 61
32009324 2020
46
Patient morbidity after impacted third molar extraction with different flap designs. A systematic review and meta-analysis. 61
32062667 2020
47
Efficacy of guselkumab in a subpopulation with pustulotic arthro-osteitis through week 52: an exploratory analysis of a phase 3, randomized, double-blind, placebo-controlled study in Japanese patients with palmoplantar pustulosis. 61
32173916 2020
48
Sex Differences in the Achievement of Remission and Low Disease Activity in Rheumatoid Arthritis. 61
30875461 2020
49
Comparison of the Effects of Secukinumab and Adalimumab Biosimilar on Radiographic Progression in Patients with Ankylosing Spondylitis: Design of a Randomized, Phase IIIb Study (SURPASS). 61
31983056 2020
50
Exosomal proteome from the serum, bone marrow, and palm and toe pustular skin tissues of a single patient with SAPHO syndrome. 61
32001333 2020
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Variations for Bone Inflammation Disease

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Expression for Bone Inflammation Disease

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Search GEO for disease gene expression data for Bone Inflammation Disease.
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Pathways for Bone Inflammation Disease

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Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 31)
# Super pathways Score Top Affiliating Genes
1
PAK Pathway 63
Show member pathways
 13.25 TNFRSF1B TNF IL6 IL1B IL17A CD4
2
Allograft rejection 1 36
Show member pathways
 12.76 TNF IL6 IL1B IL17A ICOSLG CD4
3
T cell receptor signaling pathway 36
Show member pathways
 12.54 TNF IL6 IL1B IL17A CD4
4
Th17 cell differentiation 36
Show member pathways
 12.53 TNF IL6 IL1B IL17A CD4
5
Immune response IL-23 signaling pathway 22
Show member pathways
 12.52 TNF IL6 IL1B IL17A CD4
6
MicroRNAs in cancer 36
12.47 MIR34A MIR223 MIR21 MIR155 MIR146A
7
IL-17 Family Signaling Pathways 64
Show member pathways
 12.28 TNF IL6 IL1B IL17A
8
Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.28 TNFRSF1B TNF IL6 CCR6
9
Folate Metabolism 1
Show member pathways
 12.19 TNF SERPINA3 IL6 IL1B CRP
10
Spinal Cord Injury 1
11.94 TNF IL6 IL1B ACAN
11
TNF signaling pathway 36
11.87 TNFRSF1B TNF IL6 IL1B
12
Hematopoietic cell lineage 36
11.81 TNF IL6 IL1B CD4
13
Interleukin-4 and 13 signaling 65
11.78 TNFRSF1B TNF IL6 IL1B IL17A
14
Rheumatoid arthritis 36
11.76 TNF IL6 IL1B IL17A
15
Th17 Differentiation 64
Show member pathways
 11.74 IL6 IL1B IL17A CD4
16
Pertussis 36
11.71 TNF IL6 IL1B
17
IL27-mediated signaling events 1
Show member pathways
 11.68 TNF IL6 IL1B IL17A CD4
18
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.61 TNF IL6 IL1B
19
Lung fibrosis 1
11.6 TNF IL6 IL1B
20
Dendritic Cells Developmental Lineage Pathway 64
11.57 TNF IL6 IL1B CD4
21
Legionellosis 36
11.55 TNF IL6 IL1B
22
Malaria 36
11.49 TNF IL6 IL1B
23
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.44 TNF IL6 IL1B
24
Interleukin-10 signaling 65
11.36 TNFRSF1B TNF IL6 IL1B
25
African trypanosomiasis 36
11.33 TNF IL6 IL1B
26
IL-10 Pathway 63
11.29 TNF IL6 IL1B
27
Antifolate resistance 36
11.22 TNF IL6 IL1B
28
Development and heterogeneity of the ILC family 1
10.96 TNF IL6 IL1B IL17A
29
Innate Lymphoid Cells Differentiation 64
10.92 TNF IL1B IL17A CD4 CCR6
30
Overview of nanoparticle effects 1
10.89 TNF IL6 CRP
31
Cytokines and Inflammatory Response 1
10.72 TNF IL6 IL1B CD4
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GO Terms for Bone Inflammation Disease

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Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.4 TNF SERPINA3 MIR223 MIR21 MIR155 MIR146A
2 external side of plasma membrane GO:0009897 9.35 TNF IL17A ICOSLG CD4 CCR6

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 10.05 MIR34A MIR223 MIR21 MIR155 MIR146A MIR142
2 immune response GO:0006955 10 TNFRSF1B TNF IL6 IL1B IL17A CD4
3 positive regulation of protein phosphorylation GO:0001934 9.97 TNF MIR21 IL1B CD4
4 response to lipopolysaccharide GO:0032496 9.97 TNFRSF1B MIR155 MIR142 IL1B
5 cytokine-mediated signaling pathway GO:0019221 9.97 TNFRSF1B TNF IL6 IL1B IL17A CD4
6 cellular response to hypoxia GO:0071456 9.92 MIR34A MIR155 MIR146A MIR140
7 inflammatory response GO:0006954 9.91 TNFRSF1B TNF SERPINA3 IL6 IL1B IL17A
8 positive regulation of T cell proliferation GO:0042102 9.86 IL6 IL1B CD4
9 positive regulation of inflammatory response GO:0050729 9.86 TNF MIR21 MIR155 IL1B
10 humoral immune response GO:0006959 9.85 TNF IL6 CCR6
11 positive regulation of interleukin-6 production GO:0032755 9.85 TNF IL6 IL1B
12 positive regulation of epithelial to mesenchymal transition GO:0010718 9.83 MIR21 IL6 IL1B
13 negative regulation of inflammatory response GO:0050728 9.83 TNFRSF1B MIR223 MIR155 MIR146A MIR142
14 positive regulation of interleukin-6 secretion GO:2000778 9.82 TNF IL1B IL17A
15 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.82 MIR34A MIR223 MIR140
16 negative regulation of endothelial cell proliferation GO:0001937 9.81 TNF MIR21 MIR146A
17 acute-phase response GO:0006953 9.8 SERPINA3 IL6 CRP
18 negative regulation of NIK/NF-kappaB signaling GO:1901223 9.79 MIR223 MIR21 MIR146A
19 negative regulation of cytokine production involved in inflammatory response GO:1900016 9.79 MIR155 MIR146A MIR140
20 negative regulation of interleukin-6 production GO:0032715 9.78 TNF MIR146A MIR140
21 negative regulation of vascular endothelial growth factor production GO:1904046 9.76 MIR34A MIR146A MIR140
22 negative regulation of neurogenesis GO:0050768 9.75 TNF IL6 IL1B
23 positive regulation of activated T cell proliferation GO:0042104 9.74 MIR21 MIR155 ICOSLG
24 positive regulation of glial cell proliferation GO:0060252 9.72 TNF IL6 IL1B
25 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 TNFRSF1B TNF IL1B
26 regulation of neuroinflammatory response GO:0150077 9.7 TNFRSF1B IL6
27 negative regulation of amyloid-beta clearance GO:1900222 9.7 TNF MIR34A
28 negative regulation of interleukin-8 production GO:0032717 9.7 MIR155 MIR146A
29 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.7 TNF MIR21 IL6
30 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.69 MIR155 MIR146A
31 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.69 TNF IL17A
32 regulation of establishment of endothelial barrier GO:1903140 9.69 TNF IL1B
33 negative regulation of regulatory T cell differentiation GO:0045590 9.68 MIR21 MIR155
34 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.68 MIR21 IL6
35 negative regulation of bicellular tight junction assembly GO:1903347 9.66 TNF MIR155
36 negative regulation of necrotic cell death GO:0060547 9.66 MIR223 MIR155
37 positive regulation of fever generation GO:0031622 9.65 TNF IL1B
38 negative regulation of lipid storage GO:0010888 9.65 TNF IL6 CRP
39 sequestering of triglyceride GO:0030730 9.64 TNF IL1B
40 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.62 TNF MIR21 IL6 IL17A
41 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.6 TNF IL1B
42 regulation of cytokine secretion involved in immune response GO:0002739 9.59 TNFRSF1B MIR155
43 negative regulation of vascular wound healing GO:0061044 9.58 TNF MIR34A MIR155
44 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.56 MIR34A MIR223 MIR21 MIR140
45 cellular response to lipopolysaccharide GO:0071222 9.5 TNFRSF1B TNF MIR21 MIR146A MIR140 IL6
46 positive regulation of neuroinflammatory response GO:0150078 9.46 TNF MIR142 IL6 IL1B
47 positive regulation of gene expression GO:0010628 9.32 TNF MIR34A MIR223 MIR21 MIR155 MIR146A

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL6 IL1B IL17A
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.17 MIR34A MIR223 MIR21 MIR155 MIR146A MIR142
Sources

Sources for Bone Inflammation Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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