MCID: BNN003
MIFTS: 48

Bone Inflammation Disease

Categories: Bone diseases
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Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease 11 14
Osteitis 11 43 14 71
Inflammatory Disorder of Bone 11
Bone Inflammatory Disease 11

Classifications:



External Ids:

Disease Ontology 11 DOID:3342
MeSH 43 D010000
SNOMED-CT 68 274144001
UMLS 71 C0029400

Summaries for Bone Inflammation Disease

Disease Ontology: 11 A bone disease that results in inflammation of the located in bone.

MalaCards based summary: Bone Inflammation Disease, also known as osteitis, is related to sapho syndrome and alveolar periostitis. An important gene associated with Bone Inflammation Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Toll-like receptor signaling pathway and Sudden infant death syndrome (SIDS) susceptibility pathways. The drugs Chlorhexidine and Zoledronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and prostate, and related phenotypes are immune system and hematopoietic system

Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1126)
# Related Disease Score Top Affiliating Genes
1 sapho syndrome 33.2 TNF IL17A CRP CCR6
2 alveolar periostitis 32.6 TNF IL6 CRP
3 arthritis 32.4 TNF IL6 IL1B IL17A CRP CCR6
4 osteomyelitis 32.4 TNF IL6 IL1B CRP
5 spondyloarthropathy 1 32.4 TNF IL6 IL1B IL17A ICOSLG CRP
6 synovitis 32.0 TNF IL6 IL1B CRP
7 acne 32.0 TNF IL6 IL1B IL17A CRP
8 chronic recurrent multifocal osteomyelitis 31.8 TNF IL6 IL1B CRP
9 psoriasis 14, pustular 31.8 TNF SERPINA3 IL17A
10 pustulosis of palm and sole 31.8 TNF SERPINA3 IL17A CRP CCR6
11 common cold 31.6 TNF IL6 IL1B IL17A ICOSLG CRP
12 spondylitis 31.6 TNF IL6 IL1B IL17A CRP CCR6
13 syphilis 31.5 TNF MIR142 IL17A CRP CCR6
14 bone disease 31.4 TNF SERPINA3 MIR34A MIR223 MIR210 MIR21
15 back pain 31.3 IL6 IL1B CRP
16 rheumatoid arthritis 31.2 TNF SERPINA3 MIR155 MIR146A IL6 IL1B
17 bone resorption disease 31.2 TNF MIR223 MIR210 MIR17 MIR142 MIR140
18 periostitis 31.2 TNF IL1B CRP
19 septic arthritis 31.1 TNF IL6 IL1B IL17A CRP
20 typhoid fever 31.1 TNF IL6 IL1B CRP CCR6
21 psoriatic arthritis 31.1 TNF MIR146A IL6 IL1B IL17A ICOSLG
22 tenosynovitis 31.0 TNF IL6 IL1B IL17A CRP
23 spondyloarthropathy 31.0 TNF IL6 IL1B IL17A ICOSLG CRP
24 osteoporosis 31.0 TNF MIR210 MIR21 MIR140 IL6 IL1B
25 enthesopathy 31.0 TNF IL17A CRP CCR6
26 brucellosis 31.0 TNF MIR146A IL6 IL17A CRP
27 osteonecrosis 31.0 MIR210 MIR17 IL17A
28 pulpitis 31.0 TNF IL6 IL1B
29 chronic kidney disease 31.0 TNF MIR21 MIR126 IL6 IL1B CRP
30 meningitis 30.9 TNF IL6 IL1B IL17A CRP
31 sarcoidosis 1 30.9 TNF SERPINA3 MIR155 IL6 IL1B IL17A
32 leprosy 3 30.9 TNF SERPINA3 IL6 IL1B IL17A CCR6
33 ankylosis 30.8 TNF IL17A CRP CCR6
34 paratyphoid fever 30.8 TNF IL1B CRP
35 osteoarthritis 30.8 TNF MIR140 IL6 IL1B IL17A CRP
36 periodontitis 30.8 TNF SERPINA3 MIR21 MIR17 MIR142 MIR125A
37 dermatitis 30.8 TNF IL6 IL1B IL17A CCR6
38 aspergillosis 30.8 TNF IL6 IL1B CCR6
39 arthropathy 30.8 TNF IL6 IL1B CRP CCR6
40 histiocytosis 30.8 TNF SERPINA3 IL17A CCR6
41 lymphoma, hodgkin, classic 30.8 MIR21 MIR155 MIR140 ICOSLG H2AC18 CCR6
42 langerhans cell histiocytosis 30.8 TNF SERPINA3 IL17A ICOSLG CCR6
43 exanthem 30.8 TNF IL6 IL1B IL17A ICOSLG H2AC18
44 pyoderma 30.8 TNF IL1B IL17A CRP CCR6
45 paine syndrome 30.7 TNF IL6 IL1B H2AC18
46 labyrinthitis 30.7 TNF IL1B CRP
47 reactive arthritis 30.7 TNF IL17A CRP CCR6
48 tonsillitis 30.7 TNF IL6 IL1B
49 rhinitis 30.7 TNF IL6 IL1B IL17A ICOSLG
50 prostatitis 30.7 TNF IL6 IL1B IL17A

Graphical network of the top 20 diseases related to Bone Inflammation Disease:



Diseases related to Bone Inflammation Disease

Symptoms & Phenotypes for Bone Inflammation Disease

MGI Mouse Phenotypes related to Bone Inflammation Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.86 CCR6 CRP ICOSLG IL17A IL1B IL6
2 hematopoietic system MP:0005397 9.5 CCR6 ICOSLG IL17A IL1B IL6 MIR125A

Drugs & Therapeutics for Bone Inflammation Disease

Drugs for Bone Inflammation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 2713 9552079
2
Zoledronic acid Approved Phase 4 118072-93-8 68740
3
Alendronic acid Approved Phase 4 121268-17-5, 66376-36-1 2088
4
Pamidronic acid Approved Phase 4 40391-99-9 4674
5
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 4 67-97-0, 1406-16-2 5280795 10883523
6 Calcium, Dietary Phase 4
7 Chlorhexidine gluconate Phase 4
8 Diphosphonates Phase 4
9 Micronutrients Phase 4
10 Calciferol Phase 4
11 Vitamins Phase 4
12 Trace Elements Phase 4
13
Calcium Nutraceutical Phase 4 7440-70-2 271
14
Risedronic acid Approved, Investigational Phase 3 105462-24-6 5245
15
Etidronic acid Approved Phase 3 2809-21-4, 7414-83-7 3305
16 Anti-Infective Agents Phase 3
17 Anti-Bacterial Agents Phase 3
18 Antibiotics, Antitubercular Phase 3
19 calcium channel blockers Phase 3
20
Hydrogen peroxide Approved, Vet_approved Phase 2 7722-84-1 784
21
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3 3680
22
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 3003 5743
23
Octenidine Investigational Phase 2 71251-02-0
24 Pharmaceutical Solutions Phase 2
25 Anti-Inflammatory Agents Phase 2
26 Hormones Phase 2
27 Gastrointestinal Agents Phase 2
28 glucocorticoids Phase 2
29 Antineoplastic Agents, Hormonal Phase 2
30 Dexamethasone 21-phosphate Phase 2
31 Antiemetics Phase 2
32 BB 1101 Phase 2
33
protease inhibitors Phase 2
34 Hormone Antagonists Phase 2
35 HIV Protease Inhibitors Phase 2
36
Acetylsalicylic acid Approved, Vet_approved 50-78-2 2244
37
Tetracycline Approved, Vet_approved 60-54-8 5353990
38
Peppermint oil Approved, Investigational 8006-90-4
39
Peppermint Approved
40
Silicon Approved, Investigational 7440-21-3 4082203
41
Sorbitol Approved, Investigational 69-65-8, 50-70-4 453 6251 5780
42
Menthol Approved, Experimental 1490-04-6, 2216-51-5, 15356-60-2 1254 16666 165675
43
Tocopherol Approved, Investigational 1406-66-2
44
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
45
Infliximab Approved 170277-31-3
46
Ascorbic acid Approved, Nutraceutical 50-81-7 54676860 54670067 5785
47
DL-alpha-Tocopherol Approved, Experimental, Investigational, Nutraceutical, Vet_approved 59-02-9, 10191-41-0 2116 14985
48
Tocotrienol Investigational 6829-55-6 9929901
49 Cyclooxygenase Inhibitors
50 Fibrinolytic Agents

Interventional clinical trials:

(show all 35)
# Name Status NCT ID Phase Drugs
1 Efficacy of DC071 Mouthwash (0.2% Chlorhexidine Digluconate) in Peri-surgical Care for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
2 A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China Completed NCT00774020 Phase 4 Zoledronic acid
3 An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies Completed NCT00740129 Phase 4 Zoledronic Acid
4 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4 Alendronate;Pamidronate
5 Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation Completed NCT00668200 Phase 4 Reclast (ZOL446, zoledronic acid)
6 Open Label Study to Describe the Effect of Tocilizumab in Combination With MTX in the Evolution of Articular Damage (Synovitis/Osteitis and Erosions) Evaluated by MRI in the Hand of Patients With Moderate to Severe Rheumatoid Arthritis (RA) and Inadequate Response to Non-biological DMARDs Withdrawn NCT01878318 Phase 4 methotrexate;tocilizumab [RoActemra/Actemra]
7 Antibiotic Efficacy in Third Molar Surgery Completed NCT00118820 Phase 3 IV Preoperative antibiotic or placebo
8 A 6-Month, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Alendronate 280-mg Oral Buffered Solution Once Weekly in Patients With Paget's Disease of Bone Completed NCT00480662 Phase 3 alendronate
9 Randomized, Double-Blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observation Period Completed NCT00103740 Phase 3 zoledronic acid;placebo to zoledronic acid;Risedronate;Placebo to risedronate;Calcium and vitamin D supplements
10 Randomized, Double-blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observational Period Completed NCT00051636 Phase 3 Zoledronic Acid;Risedronate;Placebo to Risedronate;Placebo to Zoledronic Acid
11 Multi-centre, Open-label, First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro Completed NCT04091399 Phase 2 Stamatological tamponade Contipro
12 Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial Suspended NCT03606980 Phase 2 Dexamethasone Sodium Phosphate
13 Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders Unknown status NCT00403598
14 Characterizing Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) With 68Ga-FAPI PET/CT Unknown status NCT04596462 Early Phase 1 68Ga-FAPI
15 Allogenic Vascularized Knee and Femur Transplantation Clinical Evaluation Unknown status NCT01133145
16 Evaluation of Platelet Rich Fibrin Use in the Treatment of Dry Socket. Unknown status NCT04476121 Nipas application
17 Comparison of Three Treatments for Lower Extremity Apophysitis Unknown status NCT01826071
18 A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery Completed NCT03494972 Tetracyclin ointment
19 Effect of Concentrated Growth Factors on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Study Completed NCT04151147
20 Post-transition Clinical and Socio-professional Future in Adult Patients With Recurrent Multifocal Chronic Osteitis Completed NCT05103137
21 Pressure Sore-related Osteitis Treated by Flap Coverage and Short Antibiotic Regimen Completed NCT03964818
22 Effect of NBF Gingival Gel Application in Controlling Post-surgical Complications After Impacted Lower Third Molar Surgery Completed NCT03641482 NBF
23 Genetic Study of Families Affected by Paget's Disease of Bone Completed NCT00747994
24 Sodium Risedronate 17.5 mg Tablets Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) - 48-week Surveillance - Completed NCT02106455 Sodium risedronate
25 Use of 18F-Fluoride Positron Emission Tomography in the Assessment and Evaluation of Therapy in Monostotic Paget's Disease of Bone Completed NCT00306046 Bisphosphonate treatment
26 Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial Completed NCT03960086
27 Effect of Hyaluronic Acid on the Therapy of Alveolar Osteitis - A Double-blind, Randomized Controlled Clinical Trial Recruiting NCT04853589
28 Bone Flap Osteomyelitis Following Craniectomy : Retrospective Evaluation of Clinical Presentation, Microbiological Diagnosis and Management Recruiting NCT05367713
29 Infliximab Proactive Drug Monitoring in the Pediatric IBD Population Recruiting NCT04921670
30 Characterization of Familial Myopathy and Paget Disease of Bone Recruiting NCT01353430
31 Prediction of IBD Disease Activity in Individual Patients Based on PROMs and Clinical Data Recruiting NCT05578768
32 Genetic Analysis to Predict the Development of Paget's Disease Recruiting NCT05309954
33 Clinical Investigation of the Efficacy of CGF (Concentrated Growth Factor) and Ozone in the Treatment of Alveolar Osteitis Active, not recruiting NCT04507009
34 Investigation of Pathophysiology of Angiogenesis and Osteogenesis in Paget's Disease of Bone Active, not recruiting NCT02802384
35 Management of Lower Limb Apophysitis: A Cross-sectional Study on Long-term Impact on Health Status Enrolling by invitation NCT04313621

Search NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

Genetic Tests for Bone Inflammation Disease

Anatomical Context for Bone Inflammation Disease

Organs/tissues related to Bone Inflammation Disease:

FMA: Bone
MalaCards : Bone, Bone Marrow, Prostate, Spinal Cord, Skin, Kidney, Thyroid

Publications for Bone Inflammation Disease

Articles related to Bone Inflammation Disease:

(show top 50) (show all 4796)
# Title Authors PMID Year
1
Hip Range of Motion and Strength in Male Athletes with Stage 1 Osteitis Pubis: A Cross-Sectional and Correlational Study. 62
36232123 2022
2
Intermetatarsal Bursitis, a Novel Feature of Juxtaarticular Inflammation in Early Rheumatoid Arthritis Related to Clinical Signs: Results of a Longitudinal Magnetic Resonance Imaging Study. 62
33973415 2022
3
Standardized reporting and quantification of whole-body MRI findings in children with chronic non-bacterial osteomyelitis treated with pamidronate. 62
36183086 2022
4
Value of a lateral inferior pedicle flap in Draf IIb for recurrent frontal sinus diseases: a prospective study. 62
35220482 2022
5
The efficacy of minocycline hydrochloride ointment versus iodoform gauze for alveolar osteitis: A prospective cohort study. 62
36258229 2022
6
Work productivity and activity in patients with SAPHO syndrome: a cross-sectional observational study. 62
36271426 2022
7
Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata. 62
36224598 2022
8
Hand and foot MRI in contemporary undifferentiated arthritis: in which patients is MRI valuable to detect rheumatoid arthritis early? A large prospective study. 62
35022703 2022
9
Performance of an MRI scoring system for inflammation of joints and entheses in peripheral SpA: post-hoc analysis of the CRESPA trial. 62
36200875 2022
10
Diagnostic Accuracy of Standalone T2 Dixon Sequence Compared with Conventional MRI in Sacroiliitis. 62
36177276 2022
11
Synovitis-acne-pustulosis-hyperostosis-osteitis Syndrome with Bilateral Pleural Effusion. 62
35135914 2022
12
Local interventions for the management of alveolar osteitis (dry socket). 62
36156769 2022
13
Athletic Osteitis Pubis Detected on 18 F-FDG PET/CT. 62
35452006 2022
14
Metallosis after using distal fibular locking plate for lateral malleolar fractures: a retrospective study. 62
33646355 2022
15
Tympanic bullae ultrasonography is feasible in nonsedated healthy rabbits (Oryctolagus cuniculus). 62
36170214 2022
16
Analysis of metabolites of fungal balls in the paranasal sinuses. 62
36100882 2022
17
Does SAPHO syndrome exist in dermatology? 62
35462435 2022
18
Occult Pulmonary Neuroendocrine Tumor Causing Severe Hyperparathyroidism: Diagnostic Challenges and Clinical Outcomes. 62
36189140 2022
19
Coincidence of pachydermoperiostosis and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, a causal or casual association? 62
35938529 2022
20
Presence of axial spondyloarthritis associated sacroiliitis and structural changes on MR enterography: A direct comparison with sacroiliac joint MRI. 62
36152432 2022
21
Clinical characteristics of pustulotic arthro-osteitis in Korea. 62
35510638 2022
22
Survey of the treatment outcome of patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis. 62
35983683 2022
23
Characteristics and incidence of vaccine adverse events after Bacille Calmette-Guérin vaccination: A national surveillance study in Japan from 2013 to 2017. 62
35690499 2022
24
Radiosurgery for Benign Vertebral Body Hemangiomas of the Spine: A Systematic Review and Meta-Analysis. 62
35378316 2022
25
Osteitis Condensans Ilii: A Case Series. 62
36148199 2022
26
Acetabular fixation in total hip arthroplasty in the previously irradiated pelvis: a review of basic science and clinical outcomes. 62
35984490 2022
27
Plate-associated localized osteitis in mini-pig by biofilm-forming Methicillin-resistant Staphylococcus aureus (MRSA): establishment of a novel experimental model. 62
35201371 2022
28
Radiographic aspects in individuals infected by human T-lymphotropic virus type 1 (HTLV-1) with joint pain. 62
35945643 2022
29
Comparison between 1.5T and 3.0T MRI: both field strengths sensitively detect subclinical inflammation of hand and forefoot in patients with arthralgia. 62
34263716 2022
30
Photobiomodulation for Managing "Dry Socket": A Randomised Controlled Trial. 62
35803777 2022
31
Three-Dimensional evaluation of the effect of platelet-rich fibrin on edema in lower impacted third molar surgery performed with piezosurgery. 62
35859473 2022
32
The use of advanced platelet-rich fibrin after surgical removal of mandibular third molars: a systematic review and meta-analysis. 62
35033409 2022
33
The Role of Prp in Third Molar Extraction Wounds: A Clinical Study. 62
36110662 2022
34
Pustulotic arthro-osteitis (Sonozaky syndrome). 62
35156627 2022
35
The challenges in diagnosis and management of osteitis pubis: An algorithm based on current evidence. 62
35783593 2022
36
Effect of initiating biologics compared to intensifying conventional DMARDs on clinical and MRI outcomes in established rheumatoid arthritis patients in clinical remission: Secondary analyses of the IMAGINE-RA trial. 62
34474649 2022
37
Sclerosis of the clavicle--A challenging diagnosis. 62
35570861 2022
38
Group B Streptococcus Bacteremia Mimicking Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome. 62
36060405 2022
39
The Outcome of Surgical Treatment for the Neuropathic Diabetic Foot Lesions-A Single-Center Study. 62
36013336 2022
40
Alveolar osteitis associated with methicillin-resistant Staphylococcus epidermidis. 62
35920878 2022
41
SAPHO syndrome and pustulotic arthro-osteitis. 62
34967407 2022
42
During development of rheumatoid arthritis, intermetatarsal bursitis may occur before clinical joint swelling: a large imaging study in patients with clinically suspect arthralgia. 62
34791051 2022
43
Pro and contra: is synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) a spondyloarthritis variant? 62
35699334 2022
44
A Rare Presentation of Rickets Mimicking Sacroiliitis: A Case Report and Literature Review. 62
35865447 2022
45
Efficiency and Safety of Dental Implantation in the Area of Hyperdense Jaw Lesions: A Narrative Review. 62
35735649 2022
46
Microbiological, Clinical and Radiological Aspects of Diabetic Foot Ulcers Infected with Methicillin-Resistant and -Sensitive Staphylococcus aureus. 62
35745555 2022
47
[Augmentation in surgical sepsis : Chances and limitations in the treatment of osteitis with calcium hydroxyapatite containing antibiotics]. 62
35546643 2022
48
Comparative Evaluation of Suture Versus Sutureless Surgery in Mandibular Third Molar Impactions. 62
35712404 2022
49
[SAPHO Syndrome Complicated with Ulcerative Colitis:Report of One Case]. 62
35791956 2022
50
The "Hand as Foot" teaching method in Whole-Body Bone Scintigraphy of synovitis-acne-pustulosis-hyperostosis-osteitis syndrome. 62
35773110 2022

Variations for Bone Inflammation Disease

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.75 TNF MIR155 MIR146A IL6 IL1B
2 12.04 TNF MIR210 IL6 IL1B
3 11.81 TNF IL6 IL1B IL17A
4
Show member pathways
11.76 TNF IL6 IL1B IL17A
5
Show member pathways
11.7 MIR223 MIR17 MIR155
6 11.67 TNF IL6 IL1B
7 11.66 TNF IL6 IL1B
8 11.62 IL6 IL1B IL17A
9 11.61 TNF IL1B IL17A CCR6
10 11.57 IL1B IL6 TNF
11
Show member pathways
11.57 IL1B IL6 TNF
12 11.55 TNF IL6 IL1B
13 11.52 CRP ICOSLG IL6 TNF
14 11.49 MIR34A MIR155 IL6
15 11.45 MIR223 MIR210 MIR21 MIR17
16 11.41 TNF IL6 IL1B
17 11.38 TNF IL6 IL1B
18 11.24 TNF IL6 IL1B
19 11.24 MIR34A MIR210 MIR21 MIR146A
20 11.16 IL1B IL6 TNF
21 11.13 TNF IL6 IL1B
22 10.96 TNF IL6 IL1B IL17A
23 10.89 TNF IL6 CRP
24 10.81 TNF MIR21 MIR155 MIR126 IL6
25 10.71 IL6 IL1B
26 10.7 TNF IL6 IL1B IL17A
27
Show member pathways
10.27 TNF IL6

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.98 CRP IL17A IL1B IL6 MIR125A MIR126
2 RISC complex GO:0016442 9.62 MIR223 MIR210 MIR21 MIR17 MIR155 MIR146A
3 extracellular vesicle GO:1903561 9.55 MIR34A MIR21 MIR17 MIR126 MIR125A

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 10.42 CRP IL17A IL1B IL6 SERPINA3 TNF
2 defense response to Gram-positive bacterium GO:0050830 10.26 CRP IL17A IL1B IL6 TNF
3 positive regulation of interleukin-6 production GO:0032755 10.22 TNF IL6 IL1B IL17A
4 acute-phase response GO:0006953 10.15 SERPINA3 IL6 CRP
5 miRNA-mediated gene silencing GO:0035195 10.13 MIR125A MIR126 MIR140 MIR142 MIR146A MIR155
6 positive regulation of inflammatory response GO:0050729 10.1 TNF MIR21 MIR126 IL1B
7 positive regulation of chemokine production GO:0032722 10.08 TNF IL6 IL1B
8 negative regulation of neurogenesis GO:0050768 10.08 IL1B IL6 TNF
9 positive regulation of glial cell proliferation GO:0060252 10.08 TNF IL6 IL1B
10 negative regulation of gene expression GO:0010629 10.06 TNF MIR34A MIR21 MIR17 MIR155 MIR146A
11 negative regulation of lipid storage GO:0010888 10.01 TNF IL6 CRP
12 vascular endothelial growth factor production GO:0010573 10 TNF IL6 IL1B
13 negative regulation of interleukin-6 production GO:0032715 9.99 TNF MIR146A MIR140 MIR125A
14 cellular response to amyloid-beta GO:1904646 9.98 TNF MIR146A MIR140
15 positive regulation of fever generation GO:0031622 9.98 TNF IL1B
16 negative regulation of inflammatory response GO:0050728 9.97 MIR126 MIR142 MIR146A MIR223
17 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.97 TNF MIR21 IL6
18 cellular response to hypoxia GO:0071456 9.97 MIR34A MIR17 MIR146A MIR140 MIR126
19 negative regulation of endothelial cell proliferation GO:0001937 9.96 TNF MIR21 MIR146A
20 cellular response to lipopolysaccharide GO:0071222 9.96 TNF MIR223 MIR21 MIR17 MIR146A MIR140
21 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 9.95 TNF MIR21 MIR17 MIR146A
22 sequestering of triglyceride GO:0030730 9.94 TNF IL1B
23 negative regulation of angiogenesis GO:0016525 9.93 MIR34A MIR21 MIR146A MIR125A
24 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.92 IL17A IL6 MIR17 MIR21 TNF
25 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.91 TNF IL1B
26 positive regulation of neuroinflammatory response GO:0150078 9.91 TNF MIR142 IL6 IL1B
27 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.86 MIR21 IL6
28 negative regulation of bicellular tight junction assembly GO:1903347 9.85 TNF MIR142
29 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.85 MIR210 MIR21 MIR17 MIR146A MIR126
30 negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 9.84 MIR34A MIR223 MIR140
31 negative regulation of NIK/NF-kappaB signaling GO:1901223 9.83 MIR223 MIR21 MIR146A
32 negative regulation of cytokine production involved in inflammatory response GO:1900016 9.8 MIR146A MIR140 MIR125A
33 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.78 MIR140 MIR21 MIR223 MIR34A
34 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.76 MIR21 MIR146A MIR126
35 miRNA-mediated gene silencing by mRNA destabilization GO:0035279 9.73 MIR223 MIR210 MIR146A MIR140
36 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.69 MIR210 MIR21 MIR17
37 positive regulation of metalloendopeptidase activity GO:1904685 9.67 MIR21 MIR17
38 negative regulation of BMP secretion GO:2001285 9.67 MIR210 MIR17 MIR140
39 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.65 MIR146A MIR125A
40 negative regulation of intracellular signal transduction GO:1902532 9.65 MIR34A MIR146A
41 positive regulation of gene expression GO:0010628 9.5 TNF MIR34A MIR223 MIR21 MIR17 MIR146A
42 negative regulation of vascular endothelial growth factor production GO:1904046 9.35 MIR34A MIR17 MIR146A MIR140 MIR125A

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA base-pairing translational repressor activity GO:1903231 9.7 MIR34A MIR223 MIR210 MIR21 MIR17 MIR155
2 mRNA 3'-UTR binding GO:0003730 9.36 MIR34A MIR223 MIR210 MIR21 MIR17 MIR155

Sources for Bone Inflammation Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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