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MCID: BNN003
MIFTS: 48

Bone Inflammation Disease

Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Bone Inflammation Disease

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MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease 12 15
Osteitis 12 43 15 71
Inflammatory Disorder of Bone 12
Bone Inflammatory Disease 12

Classifications:

MalaCards categories:
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3342
MeSH 43 D010000
SNOMED-CT 67 44462005
UMLS 71 C0029400
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Summaries for Bone Inflammation Disease

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Disease Ontology : 12 A bone disease that results in inflammation of the located in bone.

MalaCards based summary : Bone Inflammation Disease, also known as osteitis, is related to osteomyelitis and spondyloarthropathy 1. An important gene associated with Bone Inflammation Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are PAK Pathway and Allograft rejection. The drugs Alendronate and Zoledronic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and prostate.

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Related Diseases for Bone Inflammation Disease

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Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 890)
# Related Disease Score Top Affiliating Genes
1 osteomyelitis 32.8 TNF IL6 IL1B
2 spondyloarthropathy 1 32.8 TNFRSF1B TNF MRAP IL17A ICOSLG CRP
3 arthritis 32.7 TNFRSF1B TNF IL6 IL1B IL17A CRP
4 synovitis 32.4 TNF IL6 IL1B CRP ACAN
5 neurofibromatosis, type ii 32.4 TNF SERPINA3 IL6 CCR6
6 spondylitis 32.0 TNFRSF1B TNF IL6 IL17A CRP CCR6
7 syphilis 31.9 MRAP IL17A CRP CD4 CCR6
8 bone disease 31.9 TNF IL6 IL1B IL17A ICOSLG CCR6
9 bone resorption disease 31.8 TNF MIR142 MIR140 IL6 H2AC18 CRP
10 chronic recurrent multifocal osteomyelitis 31.8 TNF IL6 IL1B CRP
11 enthesopathy 31.7 TNFRSF1B TNF MRAP CRP CCR6 ACAN
12 spondyloarthropathy 31.7 TNF IL6 IL1B IL17A
13 pustulosis of palm and sole 31.6 TNFRSF1B TNF MRAP IL17A CCR6
14 rheumatic disease 31.6 TNFRSF1B TNF MIR155 MIR146A MIR142 IL1B
15 tenosynovitis 31.5 TNFRSF1B TNF MRAP IL6 CRP
16 typhoid fever 31.5 TNF IL6 IL1B CRP CCR6
17 pulpitis 31.5 TNF IL6 IL1B CCR6
18 meningitis 31.5 TNF IL6 IL1B IL17A CRP
19 psoriasis 31.4 TNFRSF1B TNF MIR21 MIR155 MIR146A MIR142
20 osteoporosis 31.4 TNFRSF1B TNF MIR21 MIR140 IL6 IL1B
21 psoriatic arthritis 31.4 TNFRSF1B TNF MIR146A IL6 IL1B IL17A
22 osteoarthritis 31.4 TNF IL6 IL1B IL17A CRP ACAN
23 brucellosis 31.4 TNF IL6 IL17A CRP
24 dermatitis 31.4 TNF MIR155 IL6 IL17A CCR6
25 ankylosis 31.4 TNFRSF1B TNF MRAP CRP CCR6
26 pyoderma 31.3 TNFRSF1B TNF CRP CCR6
27 histiocytosis 31.3 TNF SERPINA3 IL17A CCR6
28 leprosy 3 31.2 TNF IL6 IL1B IL17A CD4 CCR6
29 immune deficiency disease 31.2 TNF IL6 ICOSLG H2AC18 CD4 CCR6
30 periodontitis 31.2 TNF MIR21 MIR146A IL6 IL1B IL17A
31 myeloma, multiple 31.2 TNF MIR21 MIR155 MIR142 MIR140 IL6
32 rheumatoid arthritis 31.2 TNFRSF1B TNF SERPINA3 MIR155 MIR146A IL6
33 orchitis 31.1 TNF IL6 H2AC18 CRP CD4
34 tonsillitis 31.1 TNF IL6 IL1B
35 arthropathy 31.1 TNF IL6 IL1B CRP ACAN
36 prostatitis 31.1 TNF IL6 IL1B
37 myositis 31.1 TNF SERPINA3 IL6 IL1B IL17A ICOSLG
38 cellulitis 31.1 TNF IL6 ICOSLG CRP CD4 CCR6
39 salmonellosis 31.1 TNF IL6 IL1B CD4 CCR6
40 pneumonia 31.1 TNFRSF1B TNF IL6 IL1B IL17A CRP
41 appendicitis 31.1 TNF IL6 IL1B IL17A CRP
42 reactive arthritis 31.1 TNF IL6 IL1B IL17A CRP CCR6
43 allergic hypersensitivity disease 31.1 TNF IL17A ICOSLG H2AC18 CD4 CCR6
44 lymphadenitis 31.1 TNF SERPINA3 IL1B ICOSLG CRP CD4
45 otitis media 31.1 TNF IL6 IL1B IL17A CRP
46 iritis 31.1 TNFRSF1B TNF MRAP IL6 CRP CD4
47 exanthem 31.1 TNFRSF1B TNF IL6 ICOSLG H2AC18 CRP
48 toxic shock syndrome 31.1 TNF IL6 IL1B CRP
49 granulomatosis with polyangiitis 31.1 TNFRSF1B TNF IL17A ICOSLG CRP CD4
50 actinomycosis 31.1 H2AC18 CRP CD4

Graphical network of the top 20 diseases related to Bone Inflammation Disease:



Diseases related to Bone Inflammation Disease
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Symptoms & Phenotypes for Bone Inflammation Disease

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Drugs & Therapeutics for Bone Inflammation Disease

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Drugs for Bone Inflammation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 112)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
2
Zoledronic Acid Approved Phase 4 118072-93-8 68740
3
Pamidronate Approved Phase 4 40391-99-9 4674
4
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
5
Adalimumab Approved Phase 4 331731-18-1 16219006
6
Abatacept Approved Phase 4 332348-12-6 10237
7
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
8
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
9
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
10 Vitamins Phase 4
11 Trace Elements Phase 4
12 Micronutrients Phase 4
13 Nutrients Phase 4
14 Diphosphonates Phase 4
15 Ergocalciferols Phase 4
16 Calcium, Dietary Phase 4
17 Calciferol Phase 4
18 Vitamin D2 Phase 4
19 Anti-Inflammatory Agents Phase 4
20
Etidronic acid Approved Phase 3 2809-21-4, 7414-83-7 3305
21
Risedronate Approved, Investigational Phase 3 105462-24-6 5245
22 Antitubercular Agents Phase 3
23 Antibiotics, Antitubercular Phase 3
24 calcium channel blockers Phase 3
25
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
26
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
27
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
28
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
29 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
30
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741
31
Hydrogen peroxide Approved, Vet_approved Phase 2 7722-84-1 784
32
Amoxicillin Approved, Vet_approved Phase 1, Phase 2 26787-78-0 33613
33
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
34
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
35
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
36
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
37 Octenidine Investigational Phase 2 71251-02-0
38 Methylprednisolone Acetate Phase 2
39 Neuroprotective Agents Phase 2
40 Anti-Infective Agents Phase 1, Phase 2
41 Anti-Bacterial Agents Phase 1, Phase 2
42 Anesthetics Phase 1, Phase 2
43 Pharmaceutical Solutions Phase 2
44 Hormones Phase 2
45 Antiemetics Phase 2
46 Gastrointestinal Agents Phase 2
47 Hormone Antagonists Phase 2
48 Autonomic Agents Phase 2
49 glucocorticoids Phase 2
50 HIV Protease Inhibitors Phase 2

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 Efficacy of DC071 Mouthwash (0.2% Chlorhexidine Digluconate) in Peri-surgical Care for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
2 An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies Completed NCT00740129 Phase 4 Zoledronic Acid
3 A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China Completed NCT00774020 Phase 4 Zoledronic acid
4 Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation Completed NCT00668200 Phase 4 Reclast (ZOL446, zoledronic acid)
5 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4 Alendronate;Pamidronate
6 The Study of Efficacy and Safety of Calcium Sensing Receptor in Chronic Dialysis Patients Completed NCT02056730 Phase 4 calcium sensing receptor agonist
7 Can Bone Erosions Heal in Adalimumab (Humira) Treated Rheumatoid Arthritis Patients. An Imaging Study Using Computed Tomography and Magnetic Resonance Imaging. Completed NCT00696059 Phase 4 Adalimumab (Humira)
8 Abatacept Bone Effects in Psoriatic Arthritis With Bone Biomarkers - ABEPSA _ BB Recruiting NCT04106804 Phase 4 Abatacept 125 MG/ML
9 Open Label Study to Describe the Effect of Tocilizumab in Combination With MTX in the Evolution of Articular Damage (Synovitis/Osteitis and Erosions) Evaluated by MRI in the Hand of Patients With Moderate to Severe Rheumatoid Arthritis (RA) and Inadequate Response to Non-biological DMARDs Withdrawn NCT01878318 Phase 4 methotrexate;tocilizumab [RoActemra/Actemra]
10 A 6-Month, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Alendronate 280-mg Oral Buffered Solution Once Weekly in Patients With Paget's Disease of Bone Completed NCT00480662 Phase 3 alendronate
11 Randomized, Double-blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observational Period Completed NCT00051636 Phase 3 Zoledronic Acid;Risedronate;Placebo to Risedronate;Placebo to Zoledronic Acid
12 Randomized, Double-Blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observation Period Completed NCT00103740 Phase 3 zoledronic acid;placebo to zoledronic acid;Risedronate;Placebo to risedronate;Calcium and vitamin D supplements
13 Antibiotic Efficacy in Third Molar Surgery Completed NCT00118820 Phase 3 IV Preoperative antibiotic or placebo
14 An Open-Label, Pilot Trial to Assess the Impact of Subcutaneous Abatacept in Rheumatoid Arthritis Assessing Inhibition of Structural Damage Determined by Low Field Extremity MRI (eMRI) and X-ray Completed NCT01333878 Phase 2, Phase 3
15 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate in a Randomised Placebo Controlled Trial Unknown status NCT02594878 Phase 2 Pamidronatdinatrium
16 The Influence of Intra-alveolar Application of Honey on Healing Following Molar Teeth Extraction: A Randomized Clinical Trial Unknown status NCT02678104 Phase 2 Chlorhexidine mouth wash;Intra-alveolar application of Manuka Honey
17 MRI Evaluation Assessing Synovitis to Address the Unmet Need for Reliable Endpoints in SLE Unknown status NCT03355482 Phase 2 Methylprednisolone;Placebos
18 Multi-centre, Open-label, First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro Completed NCT04091399 Phase 2 Stamatological tamponade Contipro
19 Does a Single Dose of Systemic Antibiotics Prevent Postoperative Inflammatory Complications After Lower Third Molar Surgery? A Randomized Controlled Trial Completed NCT03130933 Phase 1, Phase 2 Amoxicillin 500 Mg
20 Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial Recruiting NCT03606980 Phase 2 Dexamethasone Sodium Phosphate
21 A Phase IIB, Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy and Safety of Fostamatinib Disodium Monotherapy Compared With Placebo or Adalimumab Monotherapy in Patients With Active Rheumatoid Arthritis: Magnetic Resonance Imaging Sub-Study Terminated NCT02092961 Phase 2 Fostamatinib;Adalimumab;Placebo of Fostamatinib;Placebo of Adalimumab
22 A Human Pilot Study to Quantify BCG From the BCG Vaccination Site, and to More Fully Characterise the Immune Response to BCG Completed NCT00653627 Phase 1
23 Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders Unknown status NCT00403598
24 Allogenic Vascularized Knee and Femur Transplantation Clinical Evaluation Unknown status NCT01133145
25 Comparison of Three Treatments for Lower Extremity Apophysitis Unknown status NCT01826071
26 Influence of Leukocyte- and Platelet Rich Fibrin (L-PRF) on the Outcomes of Impacted Mandibular Third Molar Removal Surgery: a Split-mouth Randomized Clinical Trial Unknown status NCT03357484
27 To Evaluate the Efficacy of Aloe Vera Gel in Gingival Massaging and as an Adjunct to Scaling and Root Planing in Patients With Chronic Periodontitis Unknown status NCT03083535
28 Total ExtraPeritoneal (TEP) Versus Open Minimal Suture Repair for Treatment of Sportsman's Hernia/Athletic Pubalgia: A Randomized Multi-center Trial. Unknown status NCT02297711
29 The Association of Serum Sclerostin Levels,Echocardiographic Parameters, Arteriovenous Fistula Thrombosis and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients Unknown status NCT01382966
30 Pressure Sore-related Osteitis Treated by Flap Coverage and Short Antibiotic Regimen Completed NCT03964818
31 A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery Completed NCT03494972 Tetracyclin ointment
32 Effect of NBF Gingival Gel Application in Controlling Post-surgical Complications After Impacted Lower Third Molar Surgery Completed NCT03641482 NBF
33 Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial Completed NCT03960086
34 Chronic Groin Pain and Sportsman Hernia of Athletes: Randomized Study Between Conservative Treatment and Laparoscopic Hernioplasty (TEP) Completed NCT00966589
35 Effect of Concentrated Growth Factors on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Study Completed NCT04151147
36 Management of Septic Non-union of the Tibia Using the "Induced Membrane" Technique Completed NCT03940638
37 Sodium Risedronate 17.5 mg Tablets Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) - 48-week Surveillance − Completed NCT02106455 Sodium risedronate
38 Effect of Probiotic Intervention With Lactobacillus Brevis KABP052 (CECT7480) and Lactobacillus Plantarum KABP051 (CECT7481) After Surgical Removal of Mandibular Third Molars: a Randomized, Controlled, Double-blinded Trial Completed NCT04203771 Ibuprofen
39 Evaluation of Quality of Life in Patients Undergoing Parathyroidectomy Completed NCT00905866
40 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Completed NCT00933296
41 Acutely Infected Teeth: To Extract Or Not To Extract? Completed NCT03485664
42 A Study of Maintenance Therapy After Intravenous Maxacalcitol for Secondary Hyperparathyroidism Completed NCT00828347 1.0 μg/day Alfacalcidol;0.25 μg/day Alfacalcidol
43 Does an MRI-guided Treatment Strategy Reduce Disease Activity and Progression in Patients With Rheumatoid Arthritis (RA): a Randomised Controlled Trial Completed NCT01656278
44 Clinical Outcome of Dental Extractions Among Renal Transplant Recipients Completed NCT02547753
45 Three-dimensional Measurements for Monitoring Wound Healing of Diabetic Foot Ulcers Completed NCT02423850
46 Use of 18F-Fluoride Positron Emission Tomography in the Assessment and Evaluation of Therapy in Monostotic Paget's Disease of Bone Completed NCT00306046 Bisphosphonate treatment
47 Genetic Study of Families Affected by Paget's Disease of Bone Completed NCT00747994
48 Evaluation Of Antiplaque Efficacy Of Licorice Extract Mouthrinse & Hypertonic Salt Solution And Their Comparison With Essential Oil & Chlorhexidine Mouthrinses-An Invitro & Invivo Study" Completed NCT03550651
49 The Influence of Concentrated Growth Factors (CGF) Application on Post-operative Complications. Recruiting NCT03992573
50 Characterization of Familial Myopathy and Paget Disease of Bone Recruiting NCT01353430

Search NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

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Genetic Tests for Bone Inflammation Disease

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Anatomical Context for Bone Inflammation Disease

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The Foundational Model of Anatomy Ontology organs/tissues related to Bone Inflammation Disease:

19
Bone

MalaCards organs/tissues related to Bone Inflammation Disease:

40
Bone, Skin, Prostate, Thyroid, Heart, Lung, Kidney
Sources

Publications for Bone Inflammation Disease

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Articles related to Bone Inflammation Disease:

(show top 50) (show all 4378)
# Title Authors PMID Year
1
CT-guided transarticular biopsy of the sacroiliac joint: Technique and histomorphological results. A preliminary study. 61
31485679 2020
2
Complications associated with hexapod circular fixation for acute fractures of the tibia diaphysis: A retrospective descriptive study at a high volume trauma centre. 61
31759617 2020
3
Radiological and endoscopic findings in patients undergoing revision endoscopic sinus surgery. 61
32025784 2020
4
Evaluation of Neo-Osteogenesis in Eosinophilic Chronic Rhinosinusitis Using a Nasal Polyp Murine Model. 61
32009324 2020
5
Pubic apophysitis in elite Australian Rules football players: MRI findings and the utility of VIBE sequences in evaluating athletes with groin pain. 61
32019672 2020
6
Bone turnover markers predict type of bone histomorphometry and bone mineral density in Asian chronic haemodialysis patients. 61
30980579 2020
7
Chronic pelvic sepsis with pubic bone osteitis treated with double graciloplasty. 61
31939045 2020
8
[Ignatzschineria larvae bacteremia and osteitis on a chronic wound infested by maggots]. 61
32035721 2020
9
Effects of apremilast on pustulotic arthro-osteitis in a real-world setting: report of five cases. 61
32022967 2020
10
Postpartum pubic symphysis diastasis-conservative and surgical treatment methods, incidence of complications: Two case reports and a review of the literature. 61
31970176 2020
11
Is implant placement performed at the same surgical time as orbital exenteration a viable procedure? 61
31184634 2020
12
Envelope or triangular flap for surgical removal of third molars? A systematic review and meta-analysis. 61
31974006 2020
13
Insights in clinical examination and diagnosis of Athletic Pubalgia. 61
32038025 2020
14
Demographic, clinical, and scintigraphic comparison of patients affected by palmoplantar pustulosis and severe acne: a retrospective study. 61
31953569 2020
15
SAPHO: has the time come for tailored therapy? 61
31312988 2020
16
SAPHO Syndrome Involving the Mandible Treated With 99Tc-MDP. 61
31977710 2020
17
Exosomal proteome from the serum, bone marrow, and palm and toe pustular skin tissues of a single patient with SAPHO syndrome. 61
32001333 2020
18
Comparison of the Effects of Secukinumab and Adalimumab Biosimilar on Radiographic Progression in Patients with Ankylosing Spondylitis: Design of a Randomized, Phase IIIb Study (SURPASS). 61
31983056 2020
19
Renal osteodystrophy and clinical outcomes: data from the Brazilian Registry of Bone Biopsies - REBRABO. 61
31967202 2020
20
Radiological diagnostic features of uremic leontiasis ossea: a case report. 61
31559846 2020
21
Performance of a rapid two-sequence screening protocol for osteomyelitis of the foot. 61
31938864 2020
22
Evaluation of the effects of intra-alveolar irrigation with clindamycin, rifampicin and sterile saline in alveolar osteitis treatment. 61
31991214 2020
23
Characteristics of Japanese patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis: a multicenter study. 61
31985054 2020
24
Multifocal Osteitis Camouflaging Underlying Malignancy. 61
29561465 2020
25
Crizotinib-induced osteitis mimicking bone metastasis in a stage IV ALK-rearranged NSCLC patient: a case report. 61
31906956 2020
26
A Novel Dual Action Monolithic Thermosetting Hydrogel Loaded With Lidocaine And Metronidazole As a Potential Treatment For Alveolar Osteitis. 61
32001314 2020
27
Activity of Different Antistaphylococcal Therapies, Alone or Combined, in a Rat Model of Methicillin-Resistant Staphylococcus epidermidis Osteitis without Implant. 61
31740562 2020
28
Comparison of Postoperative Outcomes Between Envelope and Triangular Flaps After Mandibular Third Molar Surgery: A Systematic Review and Meta-Analysis. 61
31883443 2019
29
Estimation of the added value of 99mTc-HMPAO-labelled white blood cell scintigraphy for the diagnosis of infectious foci. 61
28478665 2019
30
Alveolar Iodine Tampon Packing Reduces Postoperative Morbidity After Third Molar Surgery. 61
31344339 2019
31
Risk factors for neo-osteogenesis in cystic fibrosis and non-cystic fibrosis chronic rhinosinusitis. 61
31856378 2019
32
Association analysis of interleukin-23 receptor SNPs and SAPHO syndrome in Chinese people. 61
31701644 2019
33
A retrospective study of bone scintigraphy in the follow-up of patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: is it useful to repeat bone scintigraphy for disease assessment? 61
31858336 2019
34
Chest pain that does not make the cut: a case study of a surgical patient with Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis syndrome. 61
30239087 2019
35
Multiple myeloma and chemical maxillary osteonecrosis. Can both occur simultaneously? 61
31863926 2019
36
Active inflammatory changes around the pubic symphysis in patients with axial spondyloarthritis: Magnetic resonance imaging characteristics and association with clinical factors. 61
31926385 2019
37
The value of MRI examination on bilateral hands including proximal interphalangeal joints for disease assessment in patients with early rheumatoid arthritis: a cross-sectional cohort study. 61
31829263 2019
38
Gauze drain with tetracycline may reduce the risk of developing alveolar osteitis after third-molar surgical extraction. 61
31653324 2019
39
Joint Space Injection for Osteitis Pubis in an Airborne Jump Injury: A Case Report. 61
31863109 2019
40
Successful treatment of pustulotic arthro-osteitis with apremilast: a case report with follow-up MRI. 61
31903961 2019
41
Comparison of primary and secondary closure with a buccal mucosal-advancement flap on postoperative course after mandibular impacted third molar surgery. 61
31729607 2019
42
Imaging in rheumatoid arthritis: the role of magnetic resonance imaging and computed tomography. 61
30880357 2019
43
Magnetic resonance imaging of the sacroiliac joints in SpA: with or without intravenous contrast media? A preliminary report. 61
30868439 2019
44
The application of dual-energy computed tomography in the diagnosis of musculoskeletal disorders: a review of current concepts and applications. 61
30828774 2019
45
A metagenomic study of patients with alveolar osteitis after tooth extraction. A preliminary case-control study. 61
30937543 2019
46
Receptor activator of nuclear factor κB ligand is a biomarker for osteitis of chronic rhinosinusitis. 61
31693309 2019
47
Toll-like receptor 4 polymorphisms were associated with low serum pro-inflammatory cytokines in BCG osteitis survivors. 61
31755594 2019
48
Efficacy of Platelet Rich Fibrin versus chitosan as a hemostatic agent following dental extraction in patients on antiplatelet therapy. 61
31467833 2019
49
Increased nasal matrix metalloproteinase-1 and -9 expression in smokers with chronic rhinosinusitis and asthma. 61
31653934 2019
50
Successful treatment of co-existent SAPHO syndrome and hidradenitis suppurativa with adalimumab and methotrexate. 61
31535768 2019
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Variations for Bone Inflammation Disease

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Expression for Bone Inflammation Disease

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Search GEO for disease gene expression data for Bone Inflammation Disease.
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Pathways for Bone Inflammation Disease

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Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
PAK Pathway 63
Show member pathways
 13.25 TNFRSF1B TNF IL6 IL1B IL17A CD4
2
Allograft rejection 1 36
Show member pathways
 12.75 TNF IL6 IL1B IL17A ICOSLG CD4
3
T cell receptor signaling pathway 36
Show member pathways
 12.55 TNF IL6 IL1B IL17A CD4
4
Th17 cell differentiation 36
Show member pathways
 12.54 TNF IL6 IL1B IL17A CD4
5
Immune response IL-23 signaling pathway 22
Show member pathways
 12.53 TNF IL6 IL1B IL17A CD4
6
MicroRNAs in cancer 36
12.48 MIR34A MIR223 MIR21 MIR155 MIR146A
7
IL-17 Family Signaling Pathways 64
Show member pathways
 12.29 TNF IL6 IL1B IL17A
8
Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions 64
Show member pathways
 12.28 TNFRSF1B TNF IL6 CCR6
9
Folate Metabolism 1
Show member pathways
 12.21 TNF SERPINA3 IL6 IL1B CRP
10
Microglia Activation During Neuroinflammation: Overview 64
Show member pathways
 11.97 TNF IL6 IL1B ACAN
11
Spinal Cord Injury 1
11.94 TNF IL6 IL1B ACAN
12
TNF signaling pathway 36
11.87 TNFRSF1B TNF IL6 IL1B
13
Th1 Differentiation Pathway 64
Show member pathways
 11.83 TNF IL6 IL1B IL17A CD4
14
Hematopoietic cell lineage 36
11.81 TNF IL6 IL1B CD4
15
Rheumatoid arthritis 36
11.76 TNF IL6 IL1B IL17A
16
Pertussis 36
11.71 TNF IL6 IL1B
17
Interleukin-4 and 13 signaling 65
11.71 TNFRSF1B TNF IL6 IL1B IL17A
18
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.61 TNF IL6 IL1B
19
Lung fibrosis 1
11.61 TNF IL6 IL1B
20
Dendritic Cells Developmental Lineage Pathway 64
11.6 TNF IL6 IL1B CD4
21
Legionellosis 36
11.56 TNF IL6 IL1B
22
Microglia Activation During Neuroinflammation: Microglia Polarization 64
11.56 TNF IL6 IL1B IL17A
23
Malaria 36
11.5 TNF IL6 IL1B
24
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.45 TNF IL6 IL1B
25
Interleukin-10 signaling 65
11.36 TNFRSF1B TNF IL6 IL1B
26
African trypanosomiasis 36
11.33 TNF IL6 IL1B
27
IL-10 Pathway 63
11.3 TNF IL6 IL1B
28
Antifolate resistance 36
11.22 TNF IL6 IL1B
29
Development and heterogeneity of the ILC family 1
10.96 TNF IL6 IL1B IL17A
30
Innate Lymphoid Cell Differentiation Pathways 64
10.92 TNF IL1B IL17A CD4 CCR6
31
Overview of nanoparticle effects 1
10.91 TNF IL6 CRP
32
Cytokines and Inflammatory Response 1
10.72 TNF IL6 IL1B CD4
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GO Terms for Bone Inflammation Disease

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Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.4 TNF SERPINA3 MIR223 MIR21 MIR155 MIR146A
2 external side of plasma membrane GO:0009897 9.35 TNF IL17A ICOSLG CD4 CCR6

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.98 CCR6 CD4 IL17A IL1B IL6 TNF
2 positive regulation of protein phosphorylation GO:0001934 9.96 TNF MIR21 IL1B CD4
3 response to lipopolysaccharide GO:0032496 9.95 TNFRSF1B MIR155 MIR142 IL1B
4 cytokine-mediated signaling pathway GO:0019221 9.93 CD4 IL17A IL1B IL6 TNF TNFRSF1B
5 negative regulation of inflammatory response GO:0050728 9.9 MIR146A MIR155 MIR223 TNFRSF1B
6 cellular response to hypoxia GO:0071456 9.89 MIR140 MIR146A MIR155 MIR34A
7 inflammatory response GO:0006954 9.87 CRP IL17A IL1B IL6 SERPINA3 TNF
8 positive regulation of T cell proliferation GO:0042102 9.85 IL6 IL1B CD4
9 positive regulation of interleukin-6 production GO:0032755 9.85 TNF IL6 IL1B
10 gene silencing by miRNA GO:0035195 9.85 MIR140 MIR146A MIR155 MIR21 MIR223 MIR34A
11 humoral immune response GO:0006959 9.83 TNF IL6 CCR6
12 positive regulation of epithelial to mesenchymal transition GO:0010718 9.81 IL1B IL6 MIR21
13 positive regulation of inflammatory response GO:0050729 9.81 IL1B MIR155 MIR21 TNF
14 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.8 MIR140 MIR223 MIR34A
15 negative regulation of endothelial cell proliferation GO:0001937 9.79 MIR146A MIR21 TNF
16 acute-phase response GO:0006953 9.79 CRP IL6 SERPINA3
17 negative regulation of interleukin-6 production GO:0032715 9.78 MIR140 MIR146A TNF
18 positive regulation of interleukin-6 secretion GO:2000778 9.76 IL17A IL1B TNF
19 negative regulation of NIK/NF-kappaB signaling GO:1901223 9.72 MIR146A MIR21 MIR223
20 negative regulation of neurogenesis GO:0050768 9.71 IL1B IL6 TNF
21 positive regulation of activated T cell proliferation GO:0042104 9.7 ICOSLG MIR155 MIR21
22 positive regulation of chemokine biosynthetic process GO:0045080 9.68 TNF IL1B
23 negative regulation of amyloid-beta clearance GO:1900222 9.68 TNF MIR34A
24 regulation of neuroinflammatory response GO:0150077 9.68 TNFRSF1B IL6
25 negative regulation of regulatory T cell differentiation GO:0045590 9.68 MIR21 MIR155
26 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.67 MIR155 MIR146A
27 positive regulation of glial cell proliferation GO:0060252 9.67 IL1B IL6 TNF
28 regulation of establishment of endothelial barrier GO:1903140 9.66 TNF IL1B
29 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
30 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF TNFRSF1B
31 negative regulation of necrotic cell death GO:0060547 9.64 MIR155 MIR223
32 negative regulation of bicellular tight junction assembly GO:1903347 9.64 MIR155 TNF
33 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
34 regulation of cytokine secretion involved in immune response GO:0002739 9.58 MIR155 TNFRSF1B
35 negative regulation of lipid storage GO:0010888 9.58 CRP IL6 TNF
36 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IL1B TNF
37 negative regulation of vascular wound healing GO:0061044 9.56 MIR155 MIR34A
38 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.56 MIR140 MIR21 MIR223 MIR34A
39 cellular response to lipopolysaccharide GO:0071222 9.5 IL1B IL6 MIR140 MIR146A MIR21 TNF
40 positive regulation of neuroinflammatory response GO:0150078 9.46 IL1B IL6 MIR142 TNF
41 positive regulation of gene expression GO:0010628 9.32 CRP IL1B IL6 MIR140 MIR146A MIR155

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.26 TNF IL6 IL1B IL17A
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.1 MIR34A MIR223 MIR21 MIR155 MIR146A MIR140
Sources

Sources for Bone Inflammation Disease

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