MCID: BNN003
MIFTS: 48

Bone Inflammation Disease

Categories: Bone diseases

Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease 12 15
Osteitis 12 45 15 74
Inflammatory Disorder of Bone 12
Bone Inflammatory Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3342
MeSH 45 D010000
SNOMED-CT 69 44462005
UMLS 74 C0029400

Summaries for Bone Inflammation Disease

Disease Ontology : 12 A bone disease that results in inflammation of the located in bone.

MalaCards based summary : Bone Inflammation Disease, also known as osteitis, is related to osteomyelitis and spondyloarthropathy 1. An important gene associated with Bone Inflammation Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include bone, prostate and heart, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 373)
# Related Disease Score Top Affiliating Genes
1 osteomyelitis 32.0 IL1B IL1RN IL6 TNF TNFSF11
2 spondyloarthropathy 1 31.9 CRP IL17A MMP3 MRAP TNF TNFRSF1B
3 synovitis 31.3 COMP CRP IL1B IL1RN IL6 MMP13
4 arthritis 31.3 ACAN ADAMTS5 HLA-DRB1 IL17A IL1B IL1RN
5 spondylitis 30.9 CRP IL17A IL1RN IL6 TNF TNFRSF1B
6 tenosynovitis 30.8 COMP CRP MRAP TNFRSF1B
7 pneumonia 30.8 CRP IL1B IL6 TNF
8 bone disease 30.7 ACAN IL1B IL6 MMP13 TNF TNFSF11
9 pulpitis 30.6 IL1B IL6 TNF
10 otitis media 30.5 IL1B IL6 TNF
11 osteoporosis 30.5 IL1B IL1RN IL6 TNF TNFSF11
12 rheumatoid arthritis 30.5 COMP CRP HLA-DRB1 IL17A IL1B IL1RN
13 myeloma, multiple 30.4 CRP IL6 TNF TNFSF11
14 tendinitis 30.4 COMP CRP MRAP
15 appendicitis 30.4 CRP IL1B IL6 TNF
16 meningitis 30.4 CRP IL1B IL6 TNF
17 familial mediterranean fever 30.4 CRP IL1B IL1RN TNF
18 bronchiolitis 30.4 CRP IL17A IL6 TNF
19 spondyloarthropathy 30.3 IL17A IL6 MMP3 TNF TNFSF11
20 arthropathy 30.3 ACAN COMP CRP TNF TNFSF11
21 bronchiolitis obliterans 30.2 IL17A IL6 TNF
22 temporal arteritis 30.2 CRP HLA-DRB1 IL1RN IL6 SERPINA3 TNF
23 psoriatic arthritis 30.1 COMP CRP HLA-DRB1 IL17A IL1B IL6
24 histiocytosis 30.1 IL17A IL1RN SERPINA3
25 joint disorders 30.1 IL17A IL1B IL1RN IL6 MMP3 TNF
26 osteoarthritis 30.0 ACAN ADAMTS5 COMP IL1B IL6 MMP13
27 osteitis fibrosa 12.7
28 condensing osteitis of the clavicle 12.4
29 paget's disease of bone 12.3
30 aseptic osteitis 12.2
31 sapho syndrome 12.0
32 paget disease of bone 3 11.7
33 mammary paget's disease 11.7
34 mccune-albright syndrome 11.6
35 pseudohypoparathyroidism, type ib 11.1
36 monostotic fibrous dysplasia 11.1
37 caffey disease 10.9
38 epicondylitis 10.9
39 osgood-schlatter's disease 10.9
40 posterior scleritis 10.7 MRAP TNF
41 skin sarcoidosis 10.7 TNF TNFRSF1B
42 discitis 10.7 CRP MRAP
43 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 IL6 TNF
44 critical limb ischemia 10.7 IL6 TNF
45 staphylococcal toxic shock syndrome 10.7 IL1B TNF
46 drug reaction with eosinophilia and systemic symptoms 10.7 CRP TNF
47 autoimmune myocarditis 10.7 IL6 TNF
48 recurrent corneal erosion 10.7 IL1B IL6
49 bagassosis 10.7 IL1B IL6
50 leukomalacia 10.7 IL6 TNF

Graphical network of the top 20 diseases related to Bone Inflammation Disease:



Diseases related to Bone Inflammation Disease

Symptoms & Phenotypes for Bone Inflammation Disease

MGI Mouse Phenotypes related to Bone Inflammation Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 CCR6 COMP CRP IL17A IL1B IL1RN
2 immune system MP:0005387 9.93 ADAMTS5 CCR6 COMP CRP IL17A IL1B
3 integument MP:0010771 9.56 ADAMTS5 IL1B IL1RN IL6 MMP13 TNF
4 skeleton MP:0005390 9.36 ADAMTS5 COMP IL17A IL1B IL1RN IL6

Drugs & Therapeutics for Bone Inflammation Disease

Search Clinical Trials , NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

Genetic Tests for Bone Inflammation Disease

Anatomical Context for Bone Inflammation Disease

MalaCards organs/tissues related to Bone Inflammation Disease:

42
Bone, Prostate, Heart, Skin, Thyroid, Bone Marrow, Lung

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Inflammation Disease:

20
Bone

Publications for Bone Inflammation Disease

Articles related to Bone Inflammation Disease:

(show top 50) (show all 1305)
# Title Authors Year
1
Development of CT-based methods for longitudinal analyses of paranasal sinus osteitis in granulomatosis with polyangiitis. ( 30717680 )
2019
2
Monoclonal Gammopathy of Undetermined Significance in a Patient With Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis (SAPHO) Syndrome: Coincidence or Association? ( 30870251 )
2019
3
Serum levels of proinflammatory, anti-inflammatory cytokines, and RANKL/OPG in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. ( 29694253 )
2019
4
Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study. ( 30767869 )
2019
5
Bone scintigraphy analysis of 44 cases of pustulotic arthro-osteitis associated with palmoplantar pustulosis. ( 30230567 )
2019
6
Osteitis Condensans Ilii. ( 30449783 )
2019
7
Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps. ( 30537181 )
2019
8
Osteitis secondary to BCG vaccine in immunocompetent patients: Three case reports. ( 30608406 )
2019
9
Management of osteitis pubis in athletes: rehabilitation and return to training - a review of the most recent literature. ( 30613167 )
2019
10
Mycobacterium bovis Osteitis Following Immunization with Bacille Calmette-Guérin (BCG) in Korea. ( 30618511 )
2019
11
A rare presentation of Listeria monocytogenes infection: Perianal abscess associated with lumbar spine osteitis. ( 30656138 )
2019
12
Hip Arthroscopic Management Can Improve Osteitis Pubis and Bone Marrow Edema in Competitive Soccer Players With Femoroacetabular Impingement. ( 30664355 )
2019
13
Effect of antibiotic infused calcium sulfate/hydroxyapatite (CAS/HA) insets on implant-associated osteitis in a femur fracture model in mice. ( 30870491 )
2019
14
Osteitis in Chronic Rhinosinusitis. ( 30874957 )
2019
15
A metagenomic study of patients with alveolar osteitis after tooth extraction. A preliminary case-control study. ( 30937543 )
2019
16
Case report: Osteitis/osteomyelitis pubis simulating acute appendicitis. ( 30447548 )
2018
17
Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome - Two Presentations of the Same Disease? ( 30390722 )
2018
18
Correction to: Osteitis: a retrospective feasibility study comparing single-source dual-energy CT to MRI in selected patients with suspected acute gout. ( 30187109 )
2018
19
Chest pain that does not make the cut: a case study of a surgical patient with Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis syndrome. ( 30239087 )
2018
20
Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report. ( 30313072 )
2018
21
Pulmonary high-resolution computed tomography findings in patients with synovitis, acne, pustulosis, hyperostosis and osteitis syndrome. ( 30517110 )
2018
22
Melioidosis mimicking tuberculous vertebral osteitis: Case report and review of literature. ( 30038101 )
2018
23
Osteitis fibrosa cystica. ( 29415233 )
2018
24
Expansive renal osteitis fibrosa: a case report. ( 29725779 )
2018
25
Osteitis fibrosa cystica masquerading as bone neoplasm. ( 29735505 )
2018
26
Mandibular Osteitis Fibrosa Cystica as First Sign of Vitamin D Deficiency. ( 29850279 )
2018
27
Suspected Malignant Lesion of the Hip Resolves after Parathyroidectomy: Osteitis Fibrosa Cystica (or Brown Tumor): A Case Report. ( 29996036 )
2018
28
Clinical Manifestations, Management, and Outcomes of Osteitis/Osteomyelitis Caused by Mycobacterium bovis Bacillus Calmette-Guérin in Children: Comparison by Site(s) of Affected Bones. ( 30577978 )
2018
29
Does the presence of magnetic resonance imaging-detected osteitis at diagnosis with rheumatoid arthritis lower the risk for achieving disease-modifying antirheumatic drug-free sustained remission: results of a longitudinal study. ( 29636084 )
2018
30
Mandibular Osteitis Leading to the Diagnosis of SAPHO Syndrome. ( 30009075 )
2018
31
Active synovitis in the presence of osteitis predicts residual synovitis in patients with rheumatoid arthritis with a clinical response to treatment. ( 28160411 )
2018
32
Common risk factors of dry socket (alveolitis osteitis) following dental extraction: A brief narrative review. ( 29723658 )
2018
33
Role of turmeric in management of alveolar osteitis (dry socket): A randomised clinical study. ( 29556463 )
2018
34
Role of 18-fluoro-2-deoxyglucose positron emission tomography in detecting acute inflammatory lesions of non-bacterial osteitis in patients with a fever of unknown origin: A comparative study of 18-fluoro-2-deoxyglucose positron emission tomography, bone scan, and magnetic resonance imaging. ( 27321232 )
2018
35
Osteitis condensans ilii may demonstrate bone marrow edema on sacroiliac joint magnetic resonance imaging. ( 28681563 )
2018
36
Alveolar Osteitis and Third Molar Pathologies. ( 29154775 )
2018
37
Granulocyte and monocyte adsorption apheresis for palmoplantar pustulosis with extra-palmoplantar lesions and pustulotic arthro-osteitis. ( 29266440 )
2018
38
Does Intra-Alveolar Application of Chlorhexidine Gel in Combination With Platelet-Rich Fibrin Have an Advantage Over Application of Platelet-Rich Fibrin in Decreasing Alveolar Osteitis After Mandibular Third Molar Surgery? A Double-Blinded Randomized Clinical Trial. ( 29316445 )
2018
39
Effect of hyperbaric oxygen therapy (HBO) on implant-associated osteitis in a femur fracture model in mice. ( 29377928 )
2018
40
The Efficacy of Plasma Rich in Growth Factors for the Treatment of Alveolar Osteitis: A Randomized Controlled Trial. ( 29382467 )
2018
41
Evaluation of the Effect of Platelet-Rich Fibrin on the Alveolar Osteitis Incidence and Periodontal Probing Depth after Extracting Partially Erupted Mandibular Third Molars Extraction. ( 29465055 )
2018
42
From radiation osteitis to osteoradionecrosis: incidence and MR morphology of radiation-induced sacral pathologies following pelvic radiotherapy. ( 29476220 )
2018
43
Measure Of Frequency Of Alveolar Osteitis Using Two Different Methods Of Osteotomy In Mandibular Third Molar Impactions: A Double-Blind Randomized Clinical Trial. ( 29504342 )
2018
44
Difficulties in identifying the bacterial species from the genus Clostridium in a case of injury-related osteitis. ( 29524152 )
2018
45
Pustulotic Arthro-Osteitis (Sonozaki Syndrome): A Case Report and Review of Literature. ( 29531495 )
2018
46
Multifocal Osteitis Camouflaging Underlying Malignancy. ( 29561465 )
2018
47
The use of chlorhexidine in the prevention of alveolar osteitis after third molar extractions. ( 29568017 )
2018
48
Chlorhexidine gel to prevent alveolar osteitis following mandibular third molar extractions. ( 29568027 )
2018
49
Infection, Alveolar Osteitis, and Adverse Effects Using Metronidazole in Healthy Patients Undergoing Third Molar Surgery: A Meta-analysis. ( 29618877 )
2018
50
Treatment outcome and prognostic factors of tonsillectomy for palmoplantar pustulosis and pustulotic arthro-osteitis: A retrospective subjective and objective quantitative analysis of 138 patients. ( 29732605 )
2018

Variations for Bone Inflammation Disease

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14 CCR6 CRP HLA-DRB1 ICOSLG IL17A IL1B
2
Show member pathways
13.38 CCR6 IL17A IL1B IL6 TNF TNFRSF1B
3
Show member pathways
13.3 HLA-DRB1 IL17A IL1B IL1RN IL6 MMP3
4
Show member pathways
13.27 CCR6 IL17A IL1B IL6 TNF TNFRSF1B
5
Show member pathways
12.84 HLA-DRB1 ICOSLG IL17A IL1B IL6 TNF
6
Show member pathways
12.72 ACAN ADAMTS5 COMP MMP13 MMP3
7
Show member pathways
12.57 HLA-DRB1 IL17A IL1B IL6 TNF
8
Show member pathways
12.52 IL17A IL1B IL6 TNF
9 12.5 IL17A IL1B IL1RN TNF TNFRSF1B TNFSF11
10
Show member pathways
12.32 CRP IL1B IL6 SERPINA3 TNF
11
Show member pathways
12.24 IL17A IL1B IL6 MMP13 MMP3 TNF
12 12.2 HLA-DRB1 IL1B IL6 TNF
13
Show member pathways
12.19 ACAN CCR6 IL1B MMP13 MMP3
14
Show member pathways
12.19 IL1B IL1RN IL6 TNF
15 12.16 IL1B IL1RN IL6 TNF
16
Show member pathways
12.05 IL17A IL1B IL6 TNF
17 11.99 ACAN IL1B IL6 TNF
18 11.9 IL1B IL6 MMP3 TNF TNFRSF1B
19
Show member pathways
11.9 ACAN ADAMTS5 IL1B IL6 MMP3 TNF
20 11.89 HLA-DRB1 IL1B IL6 TNF
21 11.86 IL1B TNF TNFSF11
22 11.85 IL1B IL6 TNF
23 11.77 CCR6 IL17A IL1B TNF
24 11.74 IL1B IL6 TNF
25 11.72 IL1B IL6 TNF
26
Show member pathways
11.71 TNF TNFRSF1B TNFSF11
27 11.69 IL17A IL1B IL6 MMP3 TNF TNFRSF1B
28 11.65 ACAN ADAMTS5 MMP13
29 11.63 IL1B IL6 TNF
30
Show member pathways
11.62 IL1B IL6 MMP3 TNF
31 11.57 IL1B IL6 TNF
32 11.49 COMP IL1B IL6 TNF
33 11.43 IL1B IL6 TNF TNFSF11
34 11.37 IL1B IL6 TNF
35 11.34 IL1B IL6 TNF
36 11.34 IL1B IL1RN IL6 TNF TNFRSF1B
37 11.28 IL17A IL1B IL1RN IL6 MMP3 TNF
38 11.27 IL1B IL6 TNF
39 11.21 IL17A IL1B IL6 TNF
40 11.18 IL17A IL1B IL6 TNF TNFSF11
41 11.13 HLA-DRB1 IL1B IL6 TNF
42 11.13 HLA-DRB1 IL17A IL1B IL6 MMP3 TNF
43 11.03 CRP IL6 TNF
44 11.01 ACAN IL17A IL1B IL6 TNF TNFSF11

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 ADAMTS5 COMP CRP IL17A IL1B IL1RN
2 external side of plasma membrane GO:0009897 9.65 CCR6 HLA-DRB1 ICOSLG IL17A TNF
3 extracellular matrix GO:0031012 9.55 ACAN ADAMTS5 COMP MMP13 MMP3
4 extracellular region GO:0005576 9.47 ACAN ADAMTS5 COMP CRP IL17A IL1B

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 IL1B IL1RN TNF TNFSF11
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.9 IL1B IL6 TNF TNFSF11
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.86 IL1B IL6 TNF TNFSF11
4 defense response to Gram-positive bacterium GO:0050830 9.83 CRP IL6 TNF
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.83 TNF TNFRSF1B TNFSF11
6 cellular response to lipopolysaccharide GO:0071222 9.83 IL1B IL1RN IL6 TNF TNFRSF1B
7 extracellular matrix disassembly GO:0022617 9.81 ADAMTS5 MMP13 MMP3
8 positive regulation of JNK cascade GO:0046330 9.81 IL1B IL1RN TNF TNFSF11
9 humoral immune response GO:0006959 9.8 CCR6 IL6 TNF
10 inflammatory response GO:0006954 9.76 CRP IL17A IL1B IL1RN IL6 SERPINA3
11 acute-phase response GO:0006953 9.75 CRP IL6 SERPINA3
12 negative regulation of neurogenesis GO:0050768 9.72 IL1B IL6 TNF
13 positive regulation of interleukin-6 production GO:0032755 9.71 IL1B IL1RN IL6 TNF
14 positive regulation of osteoclast differentiation GO:0045672 9.7 IL17A TNF TNFSF11
15 positive regulation of glial cell proliferation GO:0060252 9.67 IL1B IL6 TNF
16 growth plate cartilage development GO:0003417 9.65 COMP MMP13
17 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
18 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF TNFRSF1B
19 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
20 response to glucocorticoid GO:0051384 9.63 IL1RN IL6 TNF
21 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.62 IL1RN IL6
22 positive regulation of fever generation GO:0031622 9.61 IL1B TNF
23 tooth eruption GO:0044691 9.61 ADAMTS5 TNFSF11
24 immune response GO:0006955 9.61 CCR6 HLA-DRB1 IL17A IL1B IL1RN IL6
25 sequestering of triglyceride GO:0030730 9.59 IL1B TNF
26 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IL1B TNF
27 negative regulation of lipid storage GO:0010888 9.54 CRP IL6 TNF
28 positive regulation of neuroinflammatory response GO:0150078 9.5 IL1B IL6 TNF
29 positive regulation of JUN kinase activity GO:0043507 9.28 TNF
30 cytokine-mediated signaling pathway GO:0019221 9.23 IL17A IL1B IL1RN IL6 MMP3 TNF
31 chronic inflammatory response to antigenic stimulus GO:0002439 8.96 TNF
32 positive regulation of gene expression GO:0010628 10.04 CRP IL1B IL6 TNF TNFSF11
33 regulation of signaling receptor activity GO:0010469 10.01 IL17A IL1B IL1RN IL6 TNF TNFSF11

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.89 ACAN ADAMTS5 BCKDHA CCR6 COMP CRP
2 interleukin-1 receptor binding GO:0005149 9.16 IL1B IL1RN
3 cytokine activity GO:0005125 9.1 IL17A IL1B IL1RN IL6 TNF TNFSF11

Sources for Bone Inflammation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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