MCID: BNN003
MIFTS: 55

Bone Inflammation Disease

Categories: Bone diseases

Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease 12 15
Osteitis 12 44 15 73
Inflammatory Disorder of Bone 12
Bone Inflammatory Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3342
MeSH 44 D010000
SNOMED-CT 68 44462005
UMLS 73 C0029400

Summaries for Bone Inflammation Disease

Disease Ontology : 12 A bone disease that results in inflammation of the located in bone.

MalaCards based summary : Bone Inflammation Disease, also known as osteitis, is related to osteomyelitis and spondyloarthropathy 1. An important gene associated with Bone Inflammation Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. Affiliated tissues include bone, prostate and t cells, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 404)
# Related Disease Score Top Affiliating Genes
1 osteomyelitis 31.6 IL1B IL1RN IL6 TNF TNFSF11
2 spondyloarthropathy 1 31.6 CRP IL17A MMP3 MRAP TNF TNFRSF1B
3 arthritis 31.1 ACAN ADAMTS5 HLA-DRB1 IL17A IL1B IL1RN
4 synovitis 31.0 COMP CRP IL1B IL1RN IL6 MMP1
5 spondylitis 30.5 CRP IL17A IL1RN IL6 TNF TNFRSF1B
6 septic arthritis 30.5 CRP MMP1 MMP3 TLR9
7 tenosynovitis 30.5 COMP CRP MRAP TNFRSF1B
8 human immunodeficiency virus infectious disease 30.4 IL6 TLR9 TNF
9 bone disease 30.4 ACAN IL1B IL6 MMP13 TNF TNFSF11
10 rheumatoid arthritis 30.3 COMP CRP HLA-DRB1 IL17A IL1B IL1RN
11 pneumonia 30.2 CRP IL1B IL6 TLR9 TNF
12 osteoporosis 30.2 CRP IL1B IL1RN IL6 MMP3 TNF
13 pulpitis 30.2 IL1B IL6 MMP1 TNF TRPV1
14 bronchiolitis obliterans 30.1 IL17A IL6 TNF
15 bone resorption disease 30.1 IL6 TNFSF11 TRPV1
16 otitis media 30.0 IL1B IL6 TNF
17 appendicitis 30.0 CRP IL1B IL6 TNF
18 familial mediterranean fever 30.0 CRP IL1B IL1RN TNF
19 bronchiolitis 30.0 CRP IL17A IL6 TLR9 TNF
20 arthropathy 30.0 ACAN COMP CRP TNF TNFSF11
21 myeloma, multiple 29.9 CRP IL6 TLR9 TNF TNFSF11
22 viral infectious disease 29.9 IL1B IL6 TLR9 TNF
23 psoriatic arthritis 29.9 COMP CRP HLA-DRB1 IL17A IL1B IL6
24 spondyloarthropathy 29.9 IL17A IL6 MMP3 MRAP TNF TNFSF11
25 psoriasis 29.9 IL17A IL1B IL6 TLR9 TNF TNFRSF1B
26 temporal arteritis 29.9 CRP HLA-DRB1 IL1RN IL6 TNF TNFRSF10A
27 osteoarthritis 29.7 ACAN ADAMTS5 COMP IL1B IL6 MMP1
28 osteitis fibrosa 12.6
29 condensing osteitis of the clavicle 12.4
30 paget's disease of bone 12.2
31 aseptic osteitis 12.2
32 sapho syndrome 12.0
33 paget disease of bone 3 11.6
34 mccune-albright syndrome 11.6
35 mammary paget's disease 11.6
36 pseudohypoparathyroidism, type ib 11.1
37 monostotic fibrous dysplasia 11.1
38 caffey disease 10.8
39 epicondylitis 10.8
40 osgood-schlatter's disease 10.8
41 hyperostosis 10.6
42 hyperparathyroidism 10.5
43 skin sarcoidosis 10.4 TNF TNFRSF1B
44 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
45 discitis 10.4 CRP MRAP
46 exudative glomerulonephritis 10.4 IL1B TNF
47 recurrent corneal erosion 10.4 IL1B IL6
48 eye lymphoma 10.4 IL6 TLR9
49 staphylococcal toxic shock syndrome 10.4 IL1B TNF
50 bagassosis 10.4 IL1B IL6

Graphical network of the top 20 diseases related to Bone Inflammation Disease:



Diseases related to Bone Inflammation Disease

Symptoms & Phenotypes for Bone Inflammation Disease

MGI Mouse Phenotypes related to Bone Inflammation Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 COMP CRP IL17A IL1B IL1RN IL6
2 immune system MP:0005387 10.13 ADAMTS5 COMP CRP IL17A IL1B IL1RN
3 integument MP:0010771 9.81 ADAMTS5 IL1B IL1RN IL6 MMP13 TNF
4 neoplasm MP:0002006 9.56 IL1B IL6 MMP1 TNF TNFRSF10A TNFRSF1B
5 skeleton MP:0005390 9.36 ADAMTS5 COMP IL17A IL1B IL1RN IL6

Drugs & Therapeutics for Bone Inflammation Disease

Search Clinical Trials , NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

Genetic Tests for Bone Inflammation Disease

Anatomical Context for Bone Inflammation Disease

MalaCards organs/tissues related to Bone Inflammation Disease:

41
Bone, Prostate, T Cells, Lung, Liver, Lymph Node, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Inflammation Disease:

19
Bone

Publications for Bone Inflammation Disease

Articles related to Bone Inflammation Disease:

(show top 50) (show all 784)
# Title Authors Year
1
Case report: Osteitis/osteomyelitis pubis simulating acute appendicitis. ( 30447548 )
2018
2
Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Synovitis Acne Pustulosis Hyperostosis Osteitis (SAPHO) Syndrome - Two Presentations of the Same Disease? ( 30390722 )
2018
3
Correction to: Osteitis: a retrospective feasibility study comparing single-source dual-energy CT to MRI in selected patients with suspected acute gout. ( 30187109 )
2018
4
Chest pain that does not make the cut: a case study of a surgical patient with Synovitis, Acne, Pustulosis, Hyperostosis and Osteitis syndrome. ( 30239087 )
2018
5
Diagnostic value of ultrasonography in synovitis-acne-pustulosis-hyperostosis-osteitis (SAPHO) syndrome: A case report. ( 30313072 )
2018
6
Pulmonary high-resolution computed tomography findings in patients with synovitis, acne, pustulosis, hyperostosis and osteitis syndrome. ( 30517110 )
2018
7
Melioidosis mimicking tuberculous vertebral osteitis: Case report and review of literature. ( 30038101 )
2018
8
Suspected Malignant Lesion of the Hip Resolves after Parathyroidectomy: Osteitis Fibrosa Cystica (or Brown Tumor): A Case Report. ( 29996036 )
2018
9
Mandibular Osteitis Leading to the Diagnosis of SAPHO Syndrome. ( 30009075 )
2018
10
Active synovitis in the presence of osteitis predicts residual synovitis in patients with rheumatoid arthritis with a clinical response to treatment. ( 28160411 )
2018
11
Common risk factors of dry socket (alveolitis osteitis) following dental extraction: A brief narrative review. ( 29723658 )
2018
12
Role of turmeric in management of alveolar osteitis (dry socket): A randomised clinical study. ( 29556463 )
2018
13
Role of 18-fluoro-2-deoxyglucose positron emission tomography in detecting acute inflammatory lesions of non-bacterial osteitis in patients with a fever of unknown origin: A comparative study of 18-fluoro-2-deoxyglucose positron emission tomography, bone scan, and magnetic resonance imaging. ( 27321232 )
2018
14
Osteitis condensans ilii may demonstrate bone marrow edema on sacroiliac joint magnetic resonance imaging. ( 28681563 )
2018
15
Alveolar Osteitis and Third Molar Pathologies. ( 29154775 )
2018
16
Granulocyte and monocyte adsorption apheresis for palmoplantar pustulosis with extra-palmoplantar lesions and pustulotic arthro-osteitis. ( 29266440 )
2018
17
Does Intra-Alveolar Application of Chlorhexidine Gel in Combination With Platelet-Rich Fibrin Have an Advantage Over Application of Platelet-Rich Fibrin in Decreasing Alveolar Osteitis After Mandibular Third Molar Surgery? A Double-Blinded Randomized Clinical Trial. ( 29316445 )
2018
18
Effect of hyperbaric oxygen therapy (HBO) on implant-associated osteitis in a femur fracture model in mice. ( 29377928 )
2018
19
The Efficacy of Plasma Rich in Growth Factors for the Treatment of Alveolar Osteitis: A Randomized Controlled Trial. ( 29382467 )
2018
20
Evaluation of the Effect of Platelet-Rich Fibrin on the Alveolar Osteitis Incidence and Periodontal Probing Depth after Extracting Partially Erupted Mandibular Third Molars Extraction. ( 29465055 )
2018
21
From radiation osteitis to osteoradionecrosis: incidence and MR morphology of radiation-induced sacral pathologies following pelvic radiotherapy. ( 29476220 )
2018
22
Measure Of Frequency Of Alveolar Osteitis Using Two Different Methods Of Osteotomy In Mandibular Third Molar Impactions: A Double-Blind Randomized Clinical Trial. ( 29504342 )
2018
23
Difficulties in identifying the bacterial species from the genus Clostridium in a case of injury-related osteitis. ( 29524152 )
2018
24
Pustulotic Arthro-Osteitis (Sonozaki Syndrome): A Case Report and Review of Literature. ( 29531495 )
2018
25
Multifocal Osteitis Camouflaging Underlying Malignancy. ( 29561465 )
2018
26
The use of chlorhexidine in the prevention of alveolar osteitis after third molar extractions. ( 29568017 )
2018
27
Chlorhexidine gel to prevent alveolar osteitis following mandibular third molar extractions. ( 29568027 )
2018
28
Infection, Alveolar Osteitis, and Adverse Effects Using Metronidazole in Healthy Patients Undergoing Third Molar Surgery: A Meta-analysis. ( 29618877 )
2018
29
Does the presence of magnetic resonance imaging-detected osteitis at diagnosis with rheumatoid arthritis lower the risk for achieving disease-modifying antirheumatic drug-free sustained remission: results of a longitudinal study. ( 29636084 )
2018
30
Treatment outcome and prognostic factors of tonsillectomy for palmoplantar pustulosis and pustulotic arthro-osteitis: A retrospective subjective and objective quantitative analysis of 138 patients. ( 29732605 )
2018
31
Chlorhexidine for prevention of alveolar osteitis: a randomised clinical trial. ( 29742264 )
2018
32
Osteitis of the cuboid on unknown foreign body. ( 29875911 )
2018
33
Angiogenesis and the prevention of alveolar osteitis: a review study. ( 29963489 )
2018
34
Management of a nonathlete with a traumatic groin strain and osteitis pubis using manual therapy and therapeutic exercise: A case report. ( 29979902 )
2018
35
Bone morphogenetic proteins - 7 and - 2 in the treatment of delayed osseous union secondary to bacterial osteitis in a rat model. ( 30049273 )
2018
36
Versatility of platelet rich fibrin in the management of alveolar osteitis-A clinical and prospective study. ( 30191106 )
2018
37
Bone scintigraphy analysis of 44 cases of pustulotic arthro-osteitis associated with palmoplantar pustulosis. ( 30230567 )
2018
38
Osteitis Condensans Ilii. ( 30449783 )
2018
39
Chronic non bacterial osteitis- a multicentre study. ( 30466444 )
2018
40
Osteitis is associated with dysregulated pro-osteoblastic activity in patients with nasal polyps. ( 30537181 )
2018
41
Evaluation of the efficacy of granulocyte and monocyte adsorption apheresis on skin manifestation and joint symptoms of patients with pustulotic arthro-osteitis. ( 30549087 )
2018
42
Osteitis as a manifestation of familial Mediterranean fever. ( 28968681 )
2017
43
Osteitis: a retrospective feasibility study comparing single-source dual-energy CT to MRI in selected patients with suspected acute gout. ( 27872954 )
2017
44
Infliximab for Treatment of Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome: A Case Report. ( 28223770 )
2017
45
Osteitis fibrosa cystica of mandible in hyperparathyroidism-jaw tumor syndrome: A rare presentation and review of literature. ( 29386822 )
2017
46
Comparative study on usefulness of gentamycin-containing collagen implants in the treatment of patients with osteitis and osteomyelitis of the craniofacial skeleton. ( 28664712 )
2017
47
Bacterial Osteomyelitis or Nonbacterial Osteitis in Children: A Study Involving the German Surveillance Unit for Rare Diseases in Childhood. ( 28403046 )
2017
48
Outcomes in diabetic foot ulcer patients with isolated T2 marrow signal abnormality in the underlying bone: should the diagnosis of "osteitis" be changed to "early osteomyelitis"? ( 28497161 )
2017
49
Effectiveness of platelet-rich fibrin in the management of pain and delayed wound healing associated with established alveolar osteitis (dry socket). ( 29279679 )
2017
50
Use of biologics for pustulotic arthro-osteitis in two patients with palmoplantar pustulosis. ( 27162198 )
2017

Variations for Bone Inflammation Disease

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 CRP HLA-DRB1 IL17A IL1B IL1RN IL6
2
Show member pathways
13.4 IL17A IL1B IL6 TLR9 TNF TNFRSF10A
3
Show member pathways
13.31 IL17A IL1B IL6 TNF TNFRSF10A TNFRSF1B
4
Show member pathways
13.3 HLA-DRB1 IL17A IL1B IL1RN IL6 MMP1
5
Show member pathways
12.88 HLA-DRB1 IL17A IL1B IL6 TNF TNFRSF1B
6
Show member pathways
12.79 HLA-DRB1 IL1B IL6 TLR9 TNF TNFRSF10A
7
Show member pathways
12.74 ACAN ADAMTS5 COMP MMP1 MMP13 MMP3
8
Show member pathways
12.71 IL1B IL6 TLR9 TNF TNFRSF1B
9
Show member pathways
12.61 IL1B TLR9 TNF TNFRSF10A TNFRSF1B TNFSF11
10
Show member pathways
12.59 HLA-DRB1 IL17A IL1B IL6 TNF
11 12.52 IL17A IL1B IL1RN TLR9 TNF TNFRSF1B
12
Show member pathways
12.43 IL17A IL1B IL6 TNF
13
Show member pathways
12.34 CRP IL1B IL6 TNF
14
Show member pathways
12.26 MMP1 MMP13 MMP3 TNFSF11
15 12.26 TNF TNFRSF10A TNFRSF1B TNFSF11
16
Show member pathways
12.23 IL1B IL1RN IL6 TNF
17
Show member pathways
12.23 ACAN IL1B MMP1 MMP13 MMP3 TLR9
18
Show member pathways
12.22 IL1B IL6 TLR9 TNF
19 12.22 HLA-DRB1 IL1B IL6 TLR9 TNF
20
Show member pathways
12.19 IL1B IL6 TLR9 TNF
21 12.19 IL6 MMP1 TLR9 TNF
22 12.18 IL1B IL1RN IL6 TNF
23
Show member pathways
12.13 IL17A IL1B IL6 MMP1 MMP13 MMP3
24
Show member pathways
12.09 IL17A IL1B IL6 TNFRSF10A TNFRSF1B
25
Show member pathways
12.07 IL17A IL1B IL6 TLR9 TNF
26 12.01 ACAN IL1B IL6 TNF
27 11.98 IL1B IL6 MMP3 TNF TNFRSF1B
28
Show member pathways
11.98 ACAN ADAMTS5 IL1B IL6 MMP3 TNF
29
Show member pathways
11.91 MMP1 MMP13 MMP3 TNF
30 11.9 HLA-DRB1 IL1B IL6 TNF
31 11.87 IL1B TNF TNFSF11
32
Show member pathways
11.83 CRP IL6 TNFSF11
33 11.79 IL17A IL1B TNF
34 11.77 IL1B IL6 TNF
35
Show member pathways
11.75 TNF TNFRSF1B TNFSF11
36 11.75 IL1B IL6 TLR9 TNF
37 11.69 ACAN ADAMTS5 MMP13
38 11.67 IL1B IL6 TNF
39 11.66 MMP1 MMP13 MMP3
40
Show member pathways
11.63 IL1B IL6 MMP1 MMP3 TNF
41 11.6 IL1B IL6 TNF
42 11.56 IL17A IL1B IL6 MMP1 MMP3 TNF
43 11.5 IL1B IL6 TNF TNFSF11
44 11.48 IL17A IL1B IL1RN IL6 MMP3 TNF
45 11.46 IL1B IL1RN IL6 TNF TNFRSF1B
46 11.42 ACAN MMP1 MMP3
47 11.41 COMP IL1B IL6 TLR9 TNF
48 11.37 IL1B IL6 TLR9 TNF
49 11.36 IL1B IL6 TNF
50 11.32 IL17A IL1B IL6 TNF

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ADAMTS5 COMP CRP IL17A IL1B IL1RN
2 extracellular matrix GO:0031012 9.63 ACAN ADAMTS5 COMP MMP1 MMP13 MMP3
3 extracellular region GO:0005576 9.5 ACAN ADAMTS5 COMP CRP IL17A IL1B

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.97 IL1B MMP1 TNF TNFRSF10A
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.92 IL1B IL1RN TLR9 TNF TNFSF11
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.91 IL1B IL6 TNF TNFSF11
4 cellular response to lipopolysaccharide GO:0071222 9.91 IL1B IL1RN IL6 TNF TNFRSF1B
5 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL1B IL6 TLR9 TNF TNFSF11
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.85 TNF TNFRSF1B TNFSF11
7 response to glucocorticoid GO:0051384 9.84 IL1B IL1RN IL6 TNF
8 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.83 IL1B TLR9 TNF
9 extrinsic apoptotic signaling pathway GO:0097191 9.82 TNF TNFRSF10A TNFRSF1B
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.81 IL1B TNF TRPV1
11 immune response GO:0006955 9.81 HLA-DRB1 IL17A IL1B IL1RN IL6 TLR9
12 collagen catabolic process GO:0030574 9.8 MMP1 MMP13 MMP3
13 extracellular matrix disassembly GO:0022617 9.8 ADAMTS5 MMP1 MMP13 MMP3
14 positive regulation of interleukin-8 production GO:0032757 9.78 IL1B TLR9 TNF
15 negative regulation of neurogenesis GO:0050768 9.77 IL1B IL6 TNF
16 positive regulation of JNK cascade GO:0046330 9.77 IL1B IL1RN TLR9 TNF TNFSF11
17 positive regulation of osteoclast differentiation GO:0045672 9.75 IL17A TNF TNFSF11
18 positive regulation of chemokine production GO:0032722 9.74 IL6 TLR9 TNF
19 positive regulation of glial cell proliferation GO:0060252 9.73 IL1B IL6 TNF
20 positive regulation of JUN kinase activity GO:0043507 9.73 IL1B IL1RN TLR9 TNF
21 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.72 IL1B TNF TNFRSF1B
22 growth plate cartilage development GO:0003417 9.68 COMP MMP13
23 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.68 IL1B TLR9
24 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.68 TLR9 TNF
25 positive regulation of chemokine biosynthetic process GO:0045080 9.67 IL1B TNF
26 negative regulation of glutamate secretion GO:0014050 9.67 IL1B IL1RN
27 regulation of establishment of endothelial barrier GO:1903140 9.66 IL1B TNF
28 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.65 IL1RN IL6
29 positive regulation of fever generation GO:0031622 9.65 IL1B TNF
30 tooth eruption GO:0044691 9.65 ADAMTS5 TNFSF11
31 positive regulation of interleukin-6 production GO:0032755 9.65 IL1B IL1RN IL6 TLR9 TNF
32 sequestering of triglyceride GO:0030730 9.63 IL1B TNF
33 negative regulation of lipid storage GO:0010888 9.63 CRP IL6 TNF
34 fever generation GO:0001660 9.62 IL1B TRPV1
35 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.62 IL1B TNF
36 inflammatory response GO:0006954 9.61 CRP IL17A IL1B IL1RN IL6 TLR9
37 positive regulation of neuroinflammatory response GO:0150078 9.58 IL1B IL6 TNF
38 chronic inflammatory response to antigenic stimulus GO:0002439 9.5 IL1B IL1RN TNF
39 cytokine-mediated signaling pathway GO:0019221 9.28 IL17A IL1B IL1RN IL6 MMP1 MMP3
40 regulation of signaling receptor activity GO:0010469 10.07 IL17A IL1B IL1RN IL6 TNF TNFSF11
41 positive regulation of gene expression GO:0010628 10.06 CRP IL1B IL6 TLR9 TNF TNFSF11

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 9.56 ADAMTS5 MMP1 MMP13 MMP3
2 metalloendopeptidase activity GO:0004222 9.46 ADAMTS5 MMP1 MMP13 MMP3
3 interleukin-1 receptor binding GO:0005149 9.13 IL1B IL1RN TLR9
4 cytokine activity GO:0005125 9.1 IL17A IL1B IL1RN IL6 TNF TNFSF11

Sources for Bone Inflammation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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