Bone Inflammation Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BNN003 MIFTS: 48	Bone Inflammation Disease Categories: Bone diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

IMPROVED

Name: Bone Inflammation Disease ¹¹ ¹⁴

Osteitis ¹¹ ⁴³ ¹⁴ ⁷¹

Inflammatory Disorder of Bone ¹¹

Bone Inflammatory Disease ¹¹

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:3342

MeSH ⁴³ D010000

SNOMED-CT ⁶⁸ 274144001

UMLS ⁷¹ C0029400

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Summaries for Bone Inflammation Disease

Disease Ontology: ¹¹ A bone disease that results in inflammation of the located in bone.

MalaCards based summary: Bone Inflammation Disease, also known as osteitis, is related to sapho syndrome and alveolar periostitis. An important gene associated with Bone Inflammation Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Toll-like receptor signaling pathway and Sudden infant death syndrome (SIDS) susceptibility pathways. The drugs Chlorhexidine and Zoledronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and prostate, and related phenotypes are immune system and hematopoietic system

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Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1126)

#	Related Disease	Score	Top Affiliating Genes
1	sapho syndrome	33.2	TNF IL17A CRP CCR6
2	alveolar periostitis	32.6	TNF IL6 CRP
3	arthritis	32.4	TNF IL6 IL1B IL17A CRP CCR6
4	osteomyelitis	32.4	TNF IL6 IL1B CRP
5	spondyloarthropathy 1	32.4	TNF IL6 IL1B IL17A ICOSLG CRP
6	synovitis	32.0	TNF IL6 IL1B CRP
7	acne	32.0	TNF IL6 IL1B IL17A CRP
8	chronic recurrent multifocal osteomyelitis	31.8	TNF IL6 IL1B CRP
9	psoriasis 14, pustular	31.8	TNF SERPINA3 IL17A
10	pustulosis of palm and sole	31.8	TNF SERPINA3 IL17A CRP CCR6
11	common cold	31.6	TNF IL6 IL1B IL17A ICOSLG CRP
12	spondylitis	31.6	TNF IL6 IL1B IL17A CRP CCR6
13	syphilis	31.5	TNF MIR142 IL17A CRP CCR6
14	bone disease	31.4	TNF SERPINA3 MIR34A MIR223 MIR210 MIR21
15	back pain	31.3	IL6 IL1B CRP
16	rheumatoid arthritis	31.2	TNF SERPINA3 MIR155 MIR146A IL6 IL1B
17	bone resorption disease	31.2	TNF MIR223 MIR210 MIR17 MIR142 MIR140
18	periostitis	31.2	TNF IL1B CRP
19	septic arthritis	31.1	TNF IL6 IL1B IL17A CRP
20	typhoid fever	31.1	TNF IL6 IL1B CRP CCR6
21	psoriatic arthritis	31.1	TNF MIR146A IL6 IL1B IL17A ICOSLG
22	tenosynovitis	31.0	TNF IL6 IL1B IL17A CRP
23	spondyloarthropathy	31.0	TNF IL6 IL1B IL17A ICOSLG CRP
24	osteoporosis	31.0	TNF MIR210 MIR21 MIR140 IL6 IL1B
25	enthesopathy	31.0	TNF IL17A CRP CCR6
26	brucellosis	31.0	TNF MIR146A IL6 IL17A CRP
27	osteonecrosis	31.0	MIR210 MIR17 IL17A
28	pulpitis	31.0	TNF IL6 IL1B
29	chronic kidney disease	31.0	TNF MIR21 MIR126 IL6 IL1B CRP
30	meningitis	30.9	TNF IL6 IL1B IL17A CRP
31	sarcoidosis 1	30.9	TNF SERPINA3 MIR155 IL6 IL1B IL17A
32	leprosy 3	30.9	TNF SERPINA3 IL6 IL1B IL17A CCR6
33	ankylosis	30.8	TNF IL17A CRP CCR6
34	paratyphoid fever	30.8	TNF IL1B CRP
35	osteoarthritis	30.8	TNF MIR140 IL6 IL1B IL17A CRP
36	periodontitis	30.8	TNF SERPINA3 MIR21 MIR17 MIR142 MIR125A
37	dermatitis	30.8	TNF IL6 IL1B IL17A CCR6
38	aspergillosis	30.8	TNF IL6 IL1B CCR6
39	arthropathy	30.8	TNF IL6 IL1B CRP CCR6
40	histiocytosis	30.8	TNF SERPINA3 IL17A CCR6
41	lymphoma, hodgkin, classic	30.8	MIR21 MIR155 MIR140 ICOSLG H2AC18 CCR6
42	langerhans cell histiocytosis	30.8	TNF SERPINA3 IL17A ICOSLG CCR6
43	exanthem	30.8	TNF IL6 IL1B IL17A ICOSLG H2AC18
44	pyoderma	30.8	TNF IL1B IL17A CRP CCR6
45	paine syndrome	30.7	TNF IL6 IL1B H2AC18
46	labyrinthitis	30.7	TNF IL1B CRP
47	reactive arthritis	30.7	TNF IL17A CRP CCR6
48	tonsillitis	30.7	TNF IL6 IL1B
49	rhinitis	30.7	TNF IL6 IL1B IL17A ICOSLG
50	prostatitis	30.7	TNF IL6 IL1B IL17A

Graphical network of the top 20 diseases related to Bone Inflammation Disease:

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Symptoms & Phenotypes for Bone Inflammation Disease

MGI Mouse Phenotypes related to Bone Inflammation Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.86	CCR6 CRP ICOSLG IL17A IL1B IL6
2	hematopoietic system	MP:0005397	9.5	CCR6 ICOSLG IL17A IL1B IL6 MIR125A

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Drugs & Therapeutics for Bone Inflammation Disease

Drugs for Bone Inflammation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 71)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Chlorhexidine

Approved, Vet_approved

Phase 4

55-56-1

2713 9552079

Zoledronic acid

Approved

Phase 4

118072-93-8

68740

Alendronic acid

Approved

Phase 4

121268-17-5, 66376-36-1

2088

Pamidronic acid

Approved

Phase 4

40391-99-9

4674

Cholecalciferol

Approved, Nutraceutical, Vet_approved

Phase 4

67-97-0, 1406-16-2

5280795 10883523

Calcium, Dietary

Phase 4

Chlorhexidine gluconate

Phase 4

Diphosphonates

Phase 4

Micronutrients

Phase 4

Calciferol

Phase 4

Vitamins

Phase 4

Trace Elements

Phase 4

Calcium

Nutraceutical

Phase 4

7440-70-2

271

Risedronic acid

Approved, Investigational

Phase 3

105462-24-6

5245

Etidronic acid

Approved

Phase 3

2809-21-4, 7414-83-7

3305

Anti-Infective Agents

Phase 3

Anti-Bacterial Agents

Phase 3

Antibiotics, Antitubercular

Phase 3

calcium channel blockers

Phase 3

Hydrogen peroxide

Approved, Vet_approved

Phase 2

7722-84-1

784

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 2

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 2

50-02-2

3003 5743

Octenidine

Investigational

Phase 2

71251-02-0

Pharmaceutical Solutions

Phase 2

Anti-Inflammatory Agents

Phase 2

Hormones

Phase 2

Gastrointestinal Agents

Phase 2

glucocorticoids

Phase 2

Antineoplastic Agents, Hormonal

Phase 2

Dexamethasone 21-phosphate

Phase 2

Antiemetics

Phase 2

BB 1101

Phase 2

protease inhibitors

Phase 2

Hormone Antagonists

Phase 2

HIV Protease Inhibitors

Phase 2

Acetylsalicylic acid

Approved, Vet_approved

50-78-2

2244

Tetracycline

Approved, Vet_approved

60-54-8

5353990

Peppermint oil

Approved, Investigational

8006-90-4

Peppermint

Approved

Silicon

Approved, Investigational

7440-21-3

4082203

Sorbitol

Approved, Investigational

69-65-8, 50-70-4

453 6251 5780

Menthol

Approved, Experimental

1490-04-6, 2216-51-5, 15356-60-2

1254 16666 165675

Tocopherol

Approved, Investigational

1406-66-2

Hyaluronic acid

Approved, Vet_approved

9004-61-9

53477741

Infliximab

Approved

170277-31-3

Ascorbic acid

Approved, Nutraceutical

50-81-7

54676860 54670067 5785

DL-alpha-Tocopherol

Approved, Experimental, Investigational, Nutraceutical, Vet_approved

59-02-9, 10191-41-0

2116 14985

Tocotrienol

Investigational

6829-55-6

9929901

Cyclooxygenase Inhibitors

Fibrinolytic Agents

Interventional clinical trials:

(show all 35)

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of DC071 Mouthwash (0.2% Chlorhexidine Digluconate) in Peri-surgical Care for Preventing Alveolar Osteitis After Third Molar Extraction	Completed	NCT02382809	Phase 4	DC071;Placebo
2	A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China	Completed	NCT00774020	Phase 4	Zoledronic acid
3	An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies	Completed	NCT00740129	Phase 4	Zoledronic Acid
4	Bisphosphonate Therapy for Osteogenesis Imperfecta	Completed	NCT00159419	Phase 4	Alendronate;Pamidronate
5	Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation	Completed	NCT00668200	Phase 4	Reclast (ZOL446, zoledronic acid)
6	Open Label Study to Describe the Effect of Tocilizumab in Combination With MTX in the Evolution of Articular Damage (Synovitis/Osteitis and Erosions) Evaluated by MRI in the Hand of Patients With Moderate to Severe Rheumatoid Arthritis (RA) and Inadequate Response to Non-biological DMARDs	Withdrawn	NCT01878318	Phase 4	methotrexate;tocilizumab [RoActemra/Actemra]
7	Antibiotic Efficacy in Third Molar Surgery	Completed	NCT00118820	Phase 3	IV Preoperative antibiotic or placebo
8	A 6-Month, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Alendronate 280-mg Oral Buffered Solution Once Weekly in Patients With Paget's Disease of Bone	Completed	NCT00480662	Phase 3	alendronate
9	Randomized, Double-Blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observation Period	Completed	NCT00103740	Phase 3	zoledronic acid;placebo to zoledronic acid;Risedronate;Placebo to risedronate;Calcium and vitamin D supplements
10	Randomized, Double-blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observational Period	Completed	NCT00051636	Phase 3	Zoledronic Acid;Risedronate;Placebo to Risedronate;Placebo to Zoledronic Acid
11	Multi-centre, Open-label, First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro	Completed	NCT04091399	Phase 2	Stamatological tamponade Contipro
12	Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial	Suspended	NCT03606980	Phase 2	Dexamethasone Sodium Phosphate
13	Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders	Unknown status	NCT00403598
14	Characterizing Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) With 68Ga-FAPI PET/CT	Unknown status	NCT04596462	Early Phase 1	68Ga-FAPI
15	Allogenic Vascularized Knee and Femur Transplantation Clinical Evaluation	Unknown status	NCT01133145
16	Evaluation of Platelet Rich Fibrin Use in the Treatment of Dry Socket.	Unknown status	NCT04476121		Nipas application
17	Comparison of Three Treatments for Lower Extremity Apophysitis	Unknown status	NCT01826071
18	A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery	Completed	NCT03494972		Tetracyclin ointment
19	Effect of Concentrated Growth Factors on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Study	Completed	NCT04151147
20	Post-transition Clinical and Socio-professional Future in Adult Patients With Recurrent Multifocal Chronic Osteitis	Completed	NCT05103137
21	Pressure Sore-related Osteitis Treated by Flap Coverage and Short Antibiotic Regimen	Completed	NCT03964818
22	Effect of NBF Gingival Gel Application in Controlling Post-surgical Complications After Impacted Lower Third Molar Surgery	Completed	NCT03641482		NBF
23	Genetic Study of Families Affected by Paget's Disease of Bone	Completed	NCT00747994
24	Sodium Risedronate 17.5 mg Tablets Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) - 48-week Surveillance -	Completed	NCT02106455		Sodium risedronate
25	Use of 18F-Fluoride Positron Emission Tomography in the Assessment and Evaluation of Therapy in Monostotic Paget's Disease of Bone	Completed	NCT00306046		Bisphosphonate treatment
26	Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial	Completed	NCT03960086
27	Effect of Hyaluronic Acid on the Therapy of Alveolar Osteitis - A Double-blind, Randomized Controlled Clinical Trial	Recruiting	NCT04853589
28	Bone Flap Osteomyelitis Following Craniectomy : Retrospective Evaluation of Clinical Presentation, Microbiological Diagnosis and Management	Recruiting	NCT05367713
29	Infliximab Proactive Drug Monitoring in the Pediatric IBD Population	Recruiting	NCT04921670
30	Characterization of Familial Myopathy and Paget Disease of Bone	Recruiting	NCT01353430
31	Prediction of IBD Disease Activity in Individual Patients Based on PROMs and Clinical Data	Recruiting	NCT05578768
32	Genetic Analysis to Predict the Development of Paget's Disease	Recruiting	NCT05309954
33	Clinical Investigation of the Efficacy of CGF (Concentrated Growth Factor) and Ozone in the Treatment of Alveolar Osteitis	Active, not recruiting	NCT04507009
34	Investigation of Pathophysiology of Angiogenesis and Osteogenesis in Paget's Disease of Bone	Active, not recruiting	NCT02802384
35	Management of Lower Limb Apophysitis: A Cross-sectional Study on Long-term Impact on Health Status	Enrolling by invitation	NCT04313621

Search NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

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Genetic Tests for Bone Inflammation Disease

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Anatomical Context for Bone Inflammation Disease

Organs/tissues related to Bone Inflammation Disease:

FMA: Bone

MalaCards : Bone, Bone Marrow, Prostate, Spinal Cord, Skin, Kidney, Thyroid

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Publications for Bone Inflammation Disease

Articles related to Bone Inflammation Disease:

(show top 50) (show all 4796)

#	Title	Authors	PMID	Year
1	Hip Range of Motion and Strength in Male Athletes with Stage 1 Osteitis Pubis: A Cross-Sectional and Correlational Study. ⁶²	Ceballos-Laita L...Jimenez-Del-Barrio S	36232123	2022
2	Intermetatarsal Bursitis, a Novel Feature of Juxtaarticular Inflammation in Early Rheumatoid Arthritis Related to Clinical Signs: Results of a Longitudinal Magnetic Resonance Imaging Study. ⁶²	van Dijk BT...van der Helm-van Mil AHM	33973415	2022
3	Standardized reporting and quantification of whole-body MRI findings in children with chronic non-bacterial osteomyelitis treated with pamidronate. ⁶²	Andreasen CM...Jurik AG	36183086	2022
4	Value of a lateral inferior pedicle flap in Draf IIb for recurrent frontal sinus diseases: a prospective study. ⁶²	He C...Zhen HT	35220482	2022
5	The efficacy of minocycline hydrochloride ointment versus iodoform gauze for alveolar osteitis: A prospective cohort study. ⁶²	Sun YQ...Zhao JH	36258229	2022
6	Work productivity and activity in patients with SAPHO syndrome: a cross-sectional observational study. ⁶²	Li C...Sun L	36271426	2022
7	Tumor necrosis factor inhibitors for pediatric patients with SAPHO syndrome associated with acne conglobata. ⁶²	Liu S...Li C	36224598	2022
8	Hand and foot MRI in contemporary undifferentiated arthritis: in which patients is MRI valuable to detect rheumatoid arthritis early? A large prospective study. ⁶²	den Hollander NK...van der Helm-van Mil AHM	35022703	2022
9	Performance of an MRI scoring system for inflammation of joints and entheses in peripheral SpA: post-hoc analysis of the CRESPA trial. ⁶²	Krabbe S...Ostergaard M	36200875	2022
10	Diagnostic Accuracy of Standalone T2 Dixon Sequence Compared with Conventional MRI in Sacroiliitis. ⁶²	Athira R...Nedunchelian M	36177276	2022
11	Synovitis-acne-pustulosis-hyperostosis-osteitis Syndrome with Bilateral Pleural Effusion. ⁶²	Adachi-Katayama M...Matsumoto I	35135914	2022
12	Local interventions for the management of alveolar osteitis (dry socket). ⁶²	Daly BJ...Beattie A	36156769	2022
13	Athletic Osteitis Pubis Detected on 18 F-FDG PET/CT. ⁶²	Broos WAM...Knol RJJ	35452006	2022
14	Metallosis after using distal fibular locking plate for lateral malleolar fractures: a retrospective study. ⁶²	Park SJ...Kwon DG	33646355	2022
15	Tympanic bullae ultrasonography is feasible in nonsedated healthy rabbits (Oryctolagus cuniculus). ⁶²	Coeuriot CTN...Fusellier MS	36170214	2022
16	Analysis of metabolites of fungal balls in the paranasal sinuses. ⁶²	Zhang X...Zhou B	36100882	2022
17	Does SAPHO syndrome exist in dermatology? ⁶²	Chen W...Plewig G	35462435	2022
18	Occult Pulmonary Neuroendocrine Tumor Causing Severe Hyperparathyroidism: Diagnostic Challenges and Clinical Outcomes. ⁶²	Yazdian A...Vaz CL	36189140	2022
19	Coincidence of pachydermoperiostosis and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, a causal or casual association? ⁶²	Feng Y...Wei S	35938529	2022
20	Presence of axial spondyloarthritis associated sacroiliitis and structural changes on MR enterography: A direct comparison with sacroiliac joint MRI. ⁶²	Ergenc I...Atagunduz MP	36152432	2022
21	Clinical characteristics of pustulotic arthro-osteitis in Korea. ⁶²	Kim M...Youn SW	35510638	2022
22	Survey of the treatment outcome of patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis. ⁶²	Hiraiwa T...Yamamoto T	35983683	2022
23	Characteristics and incidence of vaccine adverse events after Bacille Calmette-Guérin vaccination: A national surveillance study in Japan from 2013 to 2017. ⁶²	Okuno H...Tanaka-Taya K	35690499	2022
24	Radiosurgery for Benign Vertebral Body Hemangiomas of the Spine: A Systematic Review and Meta-Analysis. ⁶²	Conti A...Tuleasca C	35378316	2022
25	Osteitis Condensans Ilii: A Case Series. ⁶²	Sathu S...Maley DK	36148199	2022
26	Acetabular fixation in total hip arthroplasty in the previously irradiated pelvis: a review of basic science and clinical outcomes. ⁶²	Connors JP...Solovyova O	35984490	2022
27	Plate-associated localized osteitis in mini-pig by biofilm-forming Methicillin-resistant Staphylococcus aureus (MRSA): establishment of a novel experimental model. ⁶²	Jaekel C...Grassmann JP	35201371	2022
28	Radiographic aspects in individuals infected by human T-lymphotropic virus type 1 (HTLV-1) with joint pain. ⁶²	da Silva Carvalho JM...Carvalho EM	35945643	2022
29	Comparison between 1.5T and 3.0T MRI: both field strengths sensitively detect subclinical inflammation of hand and forefoot in patients with arthralgia. ⁶²	Krijbolder DI...van der Helm-van Mil A	34263716	2022
30	Photobiomodulation for Managing "Dry Socket": A Randomised Controlled Trial. ⁶²	ALHarthi SS...BinShabaib MS	35803777	2022
31	Three-Dimensional evaluation of the effect of platelet-rich fibrin on edema in lower impacted third molar surgery performed with piezosurgery. ⁶²	Konuk B...Senturk MF	35859473	2022
32	The use of advanced platelet-rich fibrin after surgical removal of mandibular third molars: a systematic review and meta-analysis. ⁶²	Vitenson J...Larsen MK	35033409	2022
33	The Role of Prp in Third Molar Extraction Wounds: A Clinical Study. ⁶²	Sargaiyan V...Deepalakshmi S	36110662	2022
34	Pustulotic arthro-osteitis (Sonozaky syndrome). ⁶²	Sakellariou GT...Tsifountoudis I	35156627	2022
35	The challenges in diagnosis and management of osteitis pubis: An algorithm based on current evidence. ⁶²	Amer ML...Khan MS	35783593	2022
36	Effect of initiating biologics compared to intensifying conventional DMARDs on clinical and MRI outcomes in established rheumatoid arthritis patients in clinical remission: Secondary analyses of the IMAGINE-RA trial. ⁶²	Moller-Bisgaard S...Ostergaard M	34474649	2022
37	Sclerosis of the clavicle--A challenging diagnosis. ⁶²	Davis TA...Belzarena AC	35570861	2022
38	Group B Streptococcus Bacteremia Mimicking Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) Syndrome. ⁶²	Fukuzawa F...Ikusaka M	36060405	2022
39	The Outcome of Surgical Treatment for the Neuropathic Diabetic Foot Lesions-A Single-Center Study. ⁶²	Bobirca F...Ancuta I	36013336	2022
40	Alveolar osteitis associated with methicillin-resistant Staphylococcus epidermidis. ⁶²	Buonavoglia A...Prati C	35920878	2022
41	SAPHO syndrome and pustulotic arthro-osteitis. ⁶²	Kishimoto M...Kaname S	34967407	2022
42	During development of rheumatoid arthritis, intermetatarsal bursitis may occur before clinical joint swelling: a large imaging study in patients with clinically suspect arthralgia. ⁶²	van Dijk BT...van der Helm-van Mil AHM	34791051	2022
43	Pro and contra: is synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) a spondyloarthritis variant? ⁶²	Furer V...Helliwell PS	35699334	2022
44	A Rare Presentation of Rickets Mimicking Sacroiliitis: A Case Report and Literature Review. ⁶²	Ali RS...Sen M	35865447	2022
45	Efficiency and Safety of Dental Implantation in the Area of Hyperdense Jaw Lesions: A Narrative Review. ⁶²	Taghsimi K...Babichenko II	35735649	2022
46	Microbiological, Clinical and Radiological Aspects of Diabetic Foot Ulcers Infected with Methicillin-Resistant and -Sensitive Staphylococcus aureus. ⁶²	Stankowska M...Szymanska-Dubowik A	35745555	2022
47	[Augmentation in surgical sepsis : Chances and limitations in the treatment of osteitis with calcium hydroxyapatite containing antibiotics]. ⁶²	Freischmidt H...Armbruster J	35546643	2022
48	Comparative Evaluation of Suture Versus Sutureless Surgery in Mandibular Third Molar Impactions. ⁶²	Kumar D...Bali R	35712404	2022
49	[SAPHO Syndrome Complicated with Ulcerative Colitis:Report of One Case]. ⁶²	Xie YH...Qian JM	35791956	2022
50	The "Hand as Foot" teaching method in Whole-Body Bone Scintigraphy of synovitis-acne-pustulosis-hyperostosis-osteitis syndrome. ⁶²	Niu R...He Y	35773110	2022

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Genes for Bone Inflammation Disease

Genes related to Bone Inflammation Disease (0 elite genes):

(show top 50) (show all 93)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	15.16	DISEASES inferred ¹⁴ ¹⁴
2	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	13.09	DISEASES inferred ¹⁴ ¹⁴
3	MIR140	MicroRNA 140	RNA Gene	11.99	DISEASES inferred ¹⁴ ¹⁴
4	H2AC18	H2A Clustered Histone 18	Protein Coding	11.76	DISEASES inferred ¹⁴ ¹⁴
5	SERPINA3	Serpin Family A Member 3	Protein Coding	11.21	DISEASES inferred ¹⁴ ¹⁴
6	MIR155	MicroRNA 155	RNA Gene	11.09	DISEASES inferred ¹⁴ ¹⁴
7	MIR146A	MicroRNA 146a	RNA Gene	11.07	DISEASES inferred ¹⁴ ¹⁴
8	MIR223	MicroRNA 223	RNA Gene	10.59	DISEASES inferred ¹⁴ ¹⁴
9	MIR21	MicroRNA 21	RNA Gene	10.42	DISEASES inferred ¹⁴ ¹⁴
10	MIR142	MicroRNA 142	RNA Gene	10.41	DISEASES inferred ¹⁴ ¹⁴
11	TNF	Tumor Necrosis Factor	Protein Coding	10.21	DISEASES inferred ¹⁴
12	MIR34A	MicroRNA 34a	RNA Gene	10.09	DISEASES inferred ¹⁴ ¹⁴
13	IL6	Interleukin 6	Protein Coding	9.98	DISEASES inferred ¹⁴
14	IL1B	Interleukin 1 Beta	Protein Coding	9.96	DISEASES inferred ¹⁴
15	MIR125A	MicroRNA 125a	RNA Gene	9.89	DISEASES inferred ¹⁴ ¹⁴
16	MIR126	MicroRNA 126	RNA Gene	9.83	DISEASES inferred ¹⁴ ¹⁴
17	CRP	C-Reactive Protein	Protein Coding	9.71	DISEASES inferred ¹⁴
18	MIR17	MicroRNA 17	RNA Gene	9.65	DISEASES inferred ¹⁴ ¹⁴
19	IL17A	Interleukin 17A	Protein Coding	9.59	DISEASES inferred ¹⁴
20	MIR210	MicroRNA 210	RNA Gene	9.58	DISEASES inferred ¹⁴ ¹⁴
21	MIR199A1	MicroRNA 199a-1	RNA Gene	9.58	DISEASES inferred ¹⁴ ¹⁴
22	CD4	CD4 Molecule	Protein Coding	9.37	DISEASES inferred ¹⁴
23	ACAN	Aggrecan	Protein Coding	9.36	DISEASES inferred ¹⁴
24	MIR127	MicroRNA 127	RNA Gene	9.34	DISEASES inferred ¹⁴ ¹⁴
25	IL10	Interleukin 10	Protein Coding	9.3	DISEASES inferred ¹⁴
26	MIR22	MicroRNA 22	RNA Gene	9.24	DISEASES inferred ¹⁴ ¹⁴
27	MMP13	Matrix Metallopeptidase 13	Protein Coding	9.18	DISEASES inferred ¹⁴
28	MIR30A	MicroRNA 30a	RNA Gene	9.1	DISEASES inferred ¹⁴ ¹⁴
29	MIR29A	MicroRNA 29a	RNA Gene	9.04	DISEASES inferred ¹⁴ ¹⁴
30	MIR221	MicroRNA 221	RNA Gene	9.04	DISEASES inferred ¹⁴ ¹⁴
31	TNFSF11	TNF Superfamily Member 11	Protein Coding	9.03	DISEASES inferred ¹⁴
32	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	9.02	DISEASES inferred ¹⁴
33	MIR23A	MicroRNA 23a	RNA Gene	9.02	DISEASES inferred ¹⁴ ¹⁴
34	MIR27A	MicroRNA 27a	RNA Gene	8.99	DISEASES inferred ¹⁴ ¹⁴
35	MIR24-1	MicroRNA 24-1	RNA Gene	8.98	DISEASES inferred ¹⁴ ¹⁴
36	MMP3	Matrix Metallopeptidase 3	Protein Coding	8.98	DISEASES inferred ¹⁴
37	MIR214	MicroRNA 214	RNA Gene	8.94	DISEASES inferred ¹⁴ ¹⁴
38	MIR483	MicroRNA 483	RNA Gene	8.87	DISEASES inferred ¹⁴ ¹⁴
39	IL4	Interleukin 4	Protein Coding	8.86	DISEASES inferred ¹⁴
40	CD8A	CD8a Molecule	Protein Coding	8.82	DISEASES inferred ¹⁴
41	MIR132	MicroRNA 132	RNA Gene	8.74	DISEASES inferred ¹⁴ ¹⁴
42	IL2	Interleukin 2	Protein Coding	8.71	DISEASES inferred ¹⁴
43	MIR149	MicroRNA 149	RNA Gene	8.71	DISEASES inferred ¹⁴ ¹⁴
44	ADAMTS5	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5	Protein Coding	8.7	DISEASES inferred ¹⁴
45	MIR9-1	MicroRNA 9-1	RNA Gene	8.69	DISEASES inferred ¹⁴ ¹⁴
46	MIR122	MicroRNA 122	RNA Gene	8.69	DISEASES inferred ¹⁴ ¹⁴
47	MIR29B1	MicroRNA 29b-1	RNA Gene	8.66	DISEASES inferred ¹⁴ ¹⁴
48	TLR4	Toll Like Receptor 4	Protein Coding	8.62	DISEASES inferred ¹⁴
49	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	8.6	DISEASES inferred ¹⁴
50	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	8.59	DISEASES inferred ¹⁴

Sources

Variations for Bone Inflammation Disease

Sources

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

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Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 27)

#	Super pathways	Score	Top Affiliating Genes
1	Toll-like receptor signaling pathway ⁷⁴ Show member pathways Hepatitis B infection ⁷⁴ Measles virus infection ⁷⁴ Regulation of toll-like receptor signaling pathway ⁷⁴	12.75	TNF MIR155 MIR146A IL6 IL1B
2	Sudden infant death syndrome (SIDS) susceptibility pathways ⁷⁴	12.04	TNF MIR210 IL6 IL1B
3	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.81	TNF IL6 IL1B IL17A
4	IL27-mediated signaling events ⁶¹ Show member pathways IL12 signaling pathway ⁶⁷ Th1 Differentiation ⁶⁵	11.76	TNF IL6 IL1B IL17A
5	Cell differentiation - expanded index ⁷⁴ Show member pathways Cell differentiation - index ⁷⁴	11.7	MIR223 MIR17 MIR155
6	Burn wound healing ⁷⁴	11.67	TNF IL6 IL1B
7	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.66	TNF IL6 IL1B
8	Th17 cell differentiation pathway ⁷⁴	11.62	IL6 IL1B IL17A
9	Innate Lymphoid Cells Differentiation ⁶⁵	11.61	TNF IL1B IL17A CCR6
10	Lung fibrosis ⁷⁴	11.57	IL1B IL6 TNF
11	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.57	IL1B IL6 TNF
12	IL 10 signaling pathway ⁶⁷	11.55	TNF IL6 IL1B
13	Extrafollicular B cell activation by SARS-CoV-2 ⁷⁴	11.52	CRP ICOSLG IL6 TNF
14	Hepatitis C and hepatocellular carcinoma ⁷⁴	11.49	MIR34A MIR155 IL6
15	miRNAs involved in DNA damage response ⁷⁴	11.45	MIR223 MIR210 MIR21 MIR17
16	Interleukin-10 signaling ⁶⁶	11.41	TNF IL6 IL1B
17	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.38	TNF IL6 IL1B
18	IL-10 Pathway ⁶⁴	11.24	TNF IL6 IL1B
19	Interactions between immune cells and microRNAs in tumor microenvironment ⁷⁴	11.24	MIR34A MIR210 MIR21 MIR146A
20	Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway ⁷⁴	11.16	IL1B IL6 TNF
21	Cytokines and inflammatory response ⁷⁴	11.13	TNF IL6 IL1B
22	Development and heterogeneity of the ILC family ⁷⁴	10.96	TNF IL6 IL1B IL17A
23	Overview of nanoparticle effects ⁷⁴	10.89	TNF IL6 CRP
24	miRNAs involvement in the immune response in sepsis ⁷⁴	10.81	TNF MIR21 MIR155 MIR126 IL6
25	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	10.71	IL6 IL1B
26	Prostaglandin signaling ⁷⁴	10.7	TNF IL6 IL1B IL17A
27	Cells and molecules involved in local acute inflammatory response ⁷⁴ Show member pathways IL8-mediated signaling events ⁶¹	10.27	TNF IL6

Sources

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.98	CRP IL17A IL1B IL6 MIR125A MIR126
2	RISC complex	GO:0016442	9.62	MIR223 MIR210 MIR21 MIR17 MIR155 MIR146A
3	extracellular vesicle	GO:1903561	9.55	MIR34A MIR21 MIR17 MIR126 MIR125A

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 42)

#	Name	GO ID	Score	Top Affiliating Genes
1	inflammatory response	GO:0006954	10.42	CRP IL17A IL1B IL6 SERPINA3 TNF
2	defense response to Gram-positive bacterium	GO:0050830	10.26	CRP IL17A IL1B IL6 TNF
3	positive regulation of interleukin-6 production	GO:0032755	10.22	TNF IL6 IL1B IL17A
4	acute-phase response	GO:0006953	10.15	SERPINA3 IL6 CRP
5	miRNA-mediated gene silencing	GO:0035195	10.13	MIR125A MIR126 MIR140 MIR142 MIR146A MIR155
6	positive regulation of inflammatory response	GO:0050729	10.1	TNF MIR21 MIR126 IL1B
7	positive regulation of chemokine production	GO:0032722	10.08	TNF IL6 IL1B
8	negative regulation of neurogenesis	GO:0050768	10.08	IL1B IL6 TNF
9	positive regulation of glial cell proliferation	GO:0060252	10.08	TNF IL6 IL1B
10	negative regulation of gene expression	GO:0010629	10.06	TNF MIR34A MIR21 MIR17 MIR155 MIR146A
11	negative regulation of lipid storage	GO:0010888	10.01	TNF IL6 CRP
12	vascular endothelial growth factor production	GO:0010573	10	TNF IL6 IL1B
13	negative regulation of interleukin-6 production	GO:0032715	9.99	TNF MIR146A MIR140 MIR125A
14	cellular response to amyloid-beta	GO:1904646	9.98	TNF MIR146A MIR140
15	positive regulation of fever generation	GO:0031622	9.98	TNF IL1B
16	negative regulation of inflammatory response	GO:0050728	9.97	MIR126 MIR142 MIR146A MIR223
17	positive regulation of leukocyte adhesion to vascular endothelial cell	GO:1904996	9.97	TNF MIR21 IL6
18	cellular response to hypoxia	GO:0071456	9.97	MIR34A MIR17 MIR146A MIR140 MIR126
19	negative regulation of endothelial cell proliferation	GO:0001937	9.96	TNF MIR21 MIR146A
20	cellular response to lipopolysaccharide	GO:0071222	9.96	TNF MIR223 MIR21 MIR17 MIR146A MIR140
21	positive regulation of vascular associated smooth muscle cell proliferation	GO:1904707	9.95	TNF MIR21 MIR17 MIR146A
22	sequestering of triglyceride	GO:0030730	9.94	TNF IL1B
23	negative regulation of angiogenesis	GO:0016525	9.93	MIR34A MIR21 MIR146A MIR125A
24	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.92	IL17A IL6 MIR17 MIR21 TNF
25	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.91	TNF IL1B
26	positive regulation of neuroinflammatory response	GO:0150078	9.91	TNF MIR142 IL6 IL1B
27	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.86	MIR21 IL6
28	negative regulation of bicellular tight junction assembly	GO:1903347	9.85	TNF MIR142
29	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	9.85	MIR210 MIR21 MIR17 MIR146A MIR126
30	negative regulation of vascular associated smooth muscle cell proliferation	GO:1904706	9.84	MIR34A MIR223 MIR140
31	negative regulation of NIK/NF-kappaB signaling	GO:1901223	9.83	MIR223 MIR21 MIR146A
32	negative regulation of cytokine production involved in inflammatory response	GO:1900016	9.8	MIR146A MIR140 MIR125A
33	negative regulation of vascular associated smooth muscle cell migration	GO:1904753	9.78	MIR140 MIR21 MIR223 MIR34A
34	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GO:1903589	9.76	MIR21 MIR146A MIR126
35	miRNA-mediated gene silencing by mRNA destabilization	GO:0035279	9.73	MIR223 MIR210 MIR146A MIR140
36	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.69	MIR210 MIR21 MIR17
37	positive regulation of metalloendopeptidase activity	GO:1904685	9.67	MIR21 MIR17
38	negative regulation of BMP secretion	GO:2001285	9.67	MIR210 MIR17 MIR140
39	negative regulation of leukocyte adhesion to vascular endothelial cell	GO:1904995	9.65	MIR146A MIR125A
40	negative regulation of intracellular signal transduction	GO:1902532	9.65	MIR34A MIR146A
41	positive regulation of gene expression	GO:0010628	9.5	TNF MIR34A MIR223 MIR21 MIR17 MIR146A
42	negative regulation of vascular endothelial growth factor production	GO:1904046	9.35	MIR34A MIR17 MIR146A MIR140 MIR125A

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA base-pairing translational repressor activity	GO:1903231	9.7	MIR34A MIR223 MIR210 MIR21 MIR17 MIR155
2	mRNA 3'-UTR binding	GO:0003730	9.36	MIR34A MIR223 MIR210 MIR21 MIR17 MIR155