Bone Inflammation Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BNN003 MIFTS: 48	Bone Inflammation Disease Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease ¹² ¹⁵

Osteitis ¹² ⁴⁴ ¹⁵ ⁷¹

Inflammatory Disorder of Bone ¹²

Bone Inflammatory Disease ¹²

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:3342

MeSH ⁴⁴ D010000

SNOMED-CT ⁶⁷ 274144001

UMLS ⁷¹ C0029400

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Summaries for Bone Inflammation Disease

Disease Ontology : ¹² A bone disease that results in inflammation of the located in bone.

MalaCards based summary : Bone Inflammation Disease, also known as osteitis, is related to osteomyelitis and spondyloarthropathy 1. An important gene associated with Bone Inflammation Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. The drugs Chlorhexidine and Zoledronic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and prostate.

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Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 990)

#	Related Disease	Score	Top Affiliating Genes
1	osteomyelitis	32.4	TNF IL6 IL1B CRP
2	spondyloarthropathy 1	32.3	TNF IL6 IL17A ICOSLG CRP CCR6
3	arthritis	32.3	TNF IL6 IL1B IL17A CRP CCR6
4	synovitis	32.0	TNF IL6 IL1B CRP ACAN
5	spondylitis	31.6	TNF IL6 IL1B IL17A ICOSLG CRP
6	syphilis	31.5	SERPINA3 IL17A CRP CD4 CCR6
7	bone disease	31.5	TNF IL6 IL1B IL17A CCR6 ACAN
8	chronic recurrent multifocal osteomyelitis	31.3	TNF IL6 IL1B CRP
9	bone resorption disease	31.3	TNF SERPINA3 MIR142 MIR140 IL6 IL1B
10	enthesopathy	31.3	TNF CRP CCR6 ACAN
11	rheumatoid arthritis	31.2	TNF MIR155 MIR146A IL6 IL1B IL17A
12	spondyloarthropathy	31.2	TNF IL6 IL1B IL17A
13	back pain	31.2	IL6 IL1B
14	typhoid fever	31.2	TNF IL6 IL1B CRP CCR6
15	pustulosis of palm and sole	31.1	TNF IL17A CRP CCR6
16	tenosynovitis	31.1	TNF IL6 IL1B CRP CD4
17	pulpitis	31.1	TNF IL6 IL1B CCR6
18	psoriatic arthritis	31.1	TNF MIR146A IL6 IL1B IL17A CRP
19	brucellosis	31.0	TNF IL6 IL17A CRP
20	osteoporosis	31.0	TNF MIR21 MIR140 IL6 IL1B IL17A
21	osteoarthritis	31.0	TNF IL6 IL1B IL17A CRP ACAN
22	psoriasis	31.0	TNF MIR21 MIR146A MIR142 IL6 IL1B
23	meningitis	31.0	TNF IL6 IL1B IL17A CRP
24	ankylosis	30.9	TNF IL17A CCR6
25	tonsillitis	30.8	TNF IL6 IL1B
26	pneumonia	30.8	TNF IL6 IL1B IL17A CRP
27	tertiary syphilis	30.8	TNF CRP CD4
28	histiocytosis	30.8	TNF SERPINA3 IL17A CCR6
29	prostatitis	30.8	TNF SERPINA3 IL6 IL1B IL17A
30	toxic shock syndrome	30.8	TNF IL6 IL1B CRP
31	leprosy 3	30.8	TNF IL6 IL1B IL17A CD4 CCR6
32	pyoderma	30.8	TNF IL1B CCR6
33	tetanus	30.8	TNF IL6 IL1B CRP
34	kidney disease	30.7	TNF SERPINA3 MIR223 MIR21 MIR155 MIR126
35	chronic kidney disease	30.7	TNF SERPINA3 MIR223 MIR21 MIR126 IL6
36	periodontitis	30.7	TNF SERPINA3 MIR21 MIR146A MIR125A IL6
37	otitis externa	30.7	IL6 CRP CD4
38	cellulitis	30.7	TNF IL6 CRP CD4 CCR6
39	arthropathy	30.7	TNF IL6 IL1B CRP ACAN
40	myositis	30.7	TNF SERPINA3 IL6 IL1B IL17A ICOSLG
41	appendicitis	30.7	TNF IL6 IL1B IL17A CRP
42	granulomatosis with polyangiitis	30.7	TNF MIR142 ICOSLG CRP CD4 CCR6
43	dermatitis	30.7	TNF IL6 IL1B IL17A CD4 CCR6
44	orchitis	30.7	TNF IL6 IL1B H2AC18 CRP CD4
45	reactive arthritis	30.7	TNF IL6 IL1B IL17A CRP CCR6
46	actinomycosis	30.7	TNF IL6 IL1B H2AC18 CRP CD4
47	iritis	30.7	TNF IL6 IL17A CRP CD4 CCR6
48	otitis media	30.7	TNF IL6 IL1B IL17A CRP
49	salmonellosis	30.7	TNF IL6 IL1B IL17A CD4 CCR6
50	lymphadenitis	30.7	TNF SERPINA3 IL1B ICOSLG CRP CD4

Graphical network of the top 20 diseases related to Bone Inflammation Disease:

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Symptoms & Phenotypes for Bone Inflammation Disease

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Drugs & Therapeutics for Bone Inflammation Disease

Drugs for Bone Inflammation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Chlorhexidine

Approved, Vet_approved

Phase 4

55-56-1

9552079 2713

Zoledronic Acid

Approved

Phase 4

118072-93-8

68740

Pamidronate

Approved

Phase 4

40391-99-9

4674

Alendronate

Approved

Phase 4

121268-17-5, 66376-36-1

2088

Vitamin D

Approved, Nutraceutical, Vet_approved

Phase 4

1406-16-2

Calcium, Dietary

Phase 4

Pharmaceutical Solutions

Phase 4

Chlorhexidine gluconate

Phase 4

Hormones

Phase 4

Nutrients

Phase 4

Micronutrients

Phase 4

Trace Elements

Phase 4

Vitamins

Phase 4

Diphosphonates

Phase 4

Calciferol

Phase 4

Calcium

Nutraceutical

Phase 4

7440-70-2

271

Etidronic acid

Approved

Phase 3

2809-21-4, 7414-83-7

3305

Risedronate

Approved, Investigational

Phase 3

105462-24-6

5245

Antibiotics, Antitubercular

Phase 3

Anti-Bacterial Agents

Phase 3

Anti-Infective Agents

Phase 3

calcium channel blockers

Phase 3

Hydrogen peroxide

Approved, Vet_approved

Phase 2

7722-84-1

784

Hyaluronic acid

Approved, Vet_approved

Phase 2

9004-61-9

53477741

Dexamethasone

Approved, Investigational, Vet_approved

Phase 2

50-02-2

5743

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 2

1177-87-3

Octenidine

Investigational

Phase 2

71251-02-0

Anti-Inflammatory Agents

Phase 2

Gastrointestinal Agents

Phase 2

Hormone Antagonists

Phase 2

BB 1101

Phase 2

glucocorticoids

Phase 2

HIV Protease Inhibitors

Phase 2

Antineoplastic Agents, Hormonal

Phase 2

Dexamethasone 21-phosphate

Phase 2

protease inhibitors

Phase 2

Antiemetics

Phase 2

Tetracycline

Approved, Vet_approved

60-54-8

5353990

Menthol

Approved

2216-51-5

16666

Silicon

Approved, Investigational

7440-21-3

4082203

Peppermint

Approved

Peppermint oil

Approved, Investigational

8006-90-4

Tocopherol

Approved, Investigational

1406-66-2

Sorbitol

Approved

50-70-4

5780

Aspirin

Approved, Vet_approved

50-78-2

2244

Vitamin E

Approved, Nutraceutical, Vet_approved

59-02-9

14985

Vitamin C

Approved, Nutraceutical

50-81-7

5785 54670067

Tocotrienol

Investigational

6829-55-6

Anesthetics

Cardiac Glycosides

Interventional clinical trials:

(show all 29)

#	Name	Status	NCT ID	Phase	Drugs
1	Efficacy of DC071 Mouthwash (0.2% Chlorhexidine Digluconate) in Peri-surgical Care for Preventing Alveolar Osteitis After Third Molar Extraction	Completed	NCT02382809	Phase 4	DC071;Placebo
2	An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies	Completed	NCT00740129	Phase 4	Zoledronic Acid
3	Bisphosphonate Therapy for Osteogenesis Imperfecta	Completed	NCT00159419	Phase 4	Alendronate;Pamidronate
4	A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China	Completed	NCT00774020	Phase 4	Zoledronic acid
5	Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation	Completed	NCT00668200	Phase 4	Reclast (ZOL446, zoledronic acid)
6	Open Label Study to Describe the Effect of Tocilizumab in Combination With MTX in the Evolution of Articular Damage (Synovitis/Osteitis and Erosions) Evaluated by MRI in the Hand of Patients With Moderate to Severe Rheumatoid Arthritis (RA) and Inadequate Response to Non-biological DMARDs	Withdrawn	NCT01878318	Phase 4	methotrexate;tocilizumab [RoActemra/Actemra]
7	Antibiotic Efficacy in Third Molar Surgery	Completed	NCT00118820	Phase 3	IV Preoperative antibiotic or placebo
8	Randomized, Double-blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observational Period	Completed	NCT00051636	Phase 3	Zoledronic Acid;Risedronate;Placebo to Risedronate;Placebo to Zoledronic Acid
9	Randomized, Double-Blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observation Period	Completed	NCT00103740	Phase 3	zoledronic acid;placebo to zoledronic acid;Risedronate;Placebo to risedronate;Calcium and vitamin D supplements
10	A 6-Month, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Alendronate 280-mg Oral Buffered Solution Once Weekly in Patients With Paget's Disease of Bone	Completed	NCT00480662	Phase 3	alendronate
11	Multi-centre, Open-label, First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro	Completed	NCT04091399	Phase 2	Stamatological tamponade Contipro
12	Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial	Recruiting	NCT03606980	Phase 2	Dexamethasone Sodium Phosphate
13	Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders	Unknown status	NCT00403598
14	Allogenic Vascularized Knee and Femur Transplantation Clinical Evaluation	Unknown status	NCT01133145
15	Comparison of Three Treatments for Lower Extremity Apophysitis	Unknown status	NCT01826071
16	Pressure Sore-related Osteitis Treated by Flap Coverage and Short Antibiotic Regimen	Completed	NCT03964818
17	A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery	Completed	NCT03494972		Tetracyclin ointment
18	Effect of Concentrated Growth Factors on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Study	Completed	NCT04151147
19	Effect of NBF Gingival Gel Application in Controlling Post-surgical Complications After Impacted Lower Third Molar Surgery	Completed	NCT03641482		NBF
20	Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial	Completed	NCT03960086
21	Genetic Study of Families Affected by Paget's Disease of Bone	Completed	NCT00747994
22	Use of 18F-Fluoride Positron Emission Tomography in the Assessment and Evaluation of Therapy in Monostotic Paget's Disease of Bone	Completed	NCT00306046		Bisphosphonate treatment
23	Sodium Risedronate 17.5 mg Tablets Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) - 48-week Surveillance -	Completed	NCT02106455		Sodium risedronate
24	Characterizing Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) With 68Ga-FAPI PET/CT	Recruiting	NCT04596462	Early Phase 1	68Ga-FAPI
25	Investigation of Pathophysiology of Angiogenesis and Osteogenesis in Paget's Disease of Bone	Recruiting	NCT02802384
26	Characterization of Familial Myopathy and Paget Disease of Bone	Recruiting	NCT01353430
27	Clinical Investigation of the Efficacy of CGF (Concentrated Growth Factor) and Ozone in the Treatment of Alveolar Osteitis	Active, not recruiting	NCT04507009
28	Evaluation of Platelet Rich Fibrin Use in the Treatment of Dry Socket.	Active, not recruiting	NCT04476121		Nipas application
29	Management of Lower Limb Apophysitis: A Cross-sectional Study on Long-term Impact on Health Status	Not yet recruiting	NCT04313621

Search NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

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Genetic Tests for Bone Inflammation Disease

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Anatomical Context for Bone Inflammation Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Inflammation Disease:

¹⁹

Bone

MalaCards organs/tissues related to Bone Inflammation Disease:

⁴⁰

Bone, Bone Marrow, Prostate, Spinal Cord, Neutrophil, Eye, Whole Blood

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Publications for Bone Inflammation Disease

Articles related to Bone Inflammation Disease:

(show top 50) (show all 4576)

#	Title	Authors	PMID	Year
1	Effect of platelet-rich fibrin on the control of alveolar osteitis, pain, trismus, soft tissue healing, and swelling following mandibular third molar surgery: an updated systematic review and meta-analysis. ⁶¹	Zhu J...Xu B	32950350	2021
2	A Rare Case of Nontraumatic Thoracic Compression Fracture in a 28-Year-Old Man. ⁶¹	Donohue NK...Braza DW	32618750	2021
3	The effectiveness of treatments for patients with SAPHO syndrome: a follow-up study of 24 cases from a single center and review of literature. ⁶¹	Huang H...Zhou W	32789818	2021
4	Application of propolis extract, nanovitamin C and nanovitamin E to prevent alveolar osteitis after impacted lower third molar surgery. A randomized, double-blind, split-mouth, pilot study. ⁶¹	Gonzalez-Serrano J...Lopez-Quiles J	33609021	2021
5	Interleukin 17F gene variations showed no association with BCG osteitis risk after newborn vaccination. ⁶¹	Korppi M...He Q	32946631	2021
6	The preventive effect of medicinal herbal extract and gelatin sponge on alveolar osteitis: An in vivo micro-computed tomography and immunohistochemical analysis in rats. ⁶¹	Burdurlu MC...Olgac V	33316659	2021
7	Osteitis fibrosa cystica von Recklinghausen. ⁶¹	Maanaoui M...Lionet A	33555577	2021
8	Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis. ⁶¹	Khalmuratova R...Shin HW	32877964	2021
9	Influence of computed tomographic dimensions of the nasopharynx on middle ear effusion and inflammation in pugs and French bulldogs with brachycephalic airway syndrome. ⁶¹	Krainer D...Dupre G	33595152	2021
10	Postoperative effects of intra-alveolar application of 0.2% chlorhexidine or 1% hyaluronic acid bioadhesive gels after mandibular third molar extraction: a double-blind randomized controlled clinical trial. ⁶¹	Munoz-Camara D...Camacho-Alonso F	32833133	2021
11	Intestinal ulcers induced by intravesical bacillus Calmette-Guérin therapy. ⁶¹	Tsuchiya H...Fujio K	33492192	2021
12	Contrast-enhanced T1-weighted Dixon water- and fat-only images to assess osteitis and erosions according to RAMRIS in hands of patients with early rheumatoid arthritis. ⁶¹	Kirchgesner T...Vande Berg B	33583754	2021
13	Lobular panniculitis associated with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. ⁶¹	Shao Y...Li L	32840874	2021
14	Sinus and osteitis 7 years after a sacrospinous fixation. ⁶¹	Huberts TJP...Klerkx WM	33409578	2021
15	Dietary habits in Japanese patients with palmoplantar pustulosis. ⁶¹	Serizawa N...Kanda N	33404125	2021
16	Risk factors for post-tooth extraction complications in HIV-infected patients: A retrospective study. ⁶¹	Nakagawa Y...Oka S	33518617	2021
17	Coronectomy of Mandibular Third Molars: A Systematic Literature Review and Case Studies. ⁶¹	Mann A...Scott J	33486775	2021
18	Advances in the Knowledge of the Underlying Airway Remodeling Mechanisms in Chronic Rhinosinusitis Based on the Endotypes: A Review. ⁶¹	Lee K...Kim TH	33477617	2021
19	Adult-onset Woakes' syndrome: a rare entity. ⁶¹	Salvador P...Fonseca R	33431532	2021
20	Baricitinib inhibits structural joint damage progression in patients with rheumatoid arthritis-a comprehensive review. ⁶¹	Emery P...Tanaka Y	33397481	2021
21	Predictors of joint damage progression and stringent remission in patients with established rheumatoid arthritis in clinical remission. ⁶¹	Moller-Bisgaard S...Ostergaard M	32929463	2021
22	Serum interleukin-23 protects, whereas methotrexate treatment stimulates selected components of the metabolic syndrome in patients with SAPHO syndrome. ⁶¹	Przepiera-Bedzak H...Brzosko M	33488864	2021
23	Osteitis condensans ilii in a patient with ulcerative colitis: a mimic of ankylosing spondylitis or non-radiographic axial spondyloarthritis. ⁶¹	Otomo K...Takeuchi T	33250009	2021
24	Tripterygium wilfordii Hook F. in the treatment of synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a clinical trial. ⁶¹	Wang L...Li C	33389313	2021
25	Disease activity in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: the utility of the SPARCC MRI scoring system for assessment of axial spine involvement. ⁶¹	Gu Z...Zhang W	33427614	2021
26	Tofacitinib for the Treatment of Nail Lesions and Palmoplantar Pustulosis in Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome. ⁶¹	Li C...Zeng X	32997094	2021
27	Impact of baseline clinical and radiological features on outcome of chronic rhinosinusitis in granulomatosis with polyangiitis. ⁶¹	Holme SS...Molberg O	33430923	2021
28	Rituximab plus belimumab in non-infectious refractory cryoglobulinemia vasculitis: A pilot study. ⁶¹	Saadoun D...Cacoub P	33248866	2021
29	Ankle arthritis - an important signpost in rheumatologic practice. ⁶¹	Kiely PDW...Lloyd ME	33097958	2021
30	Severe, rigid cervical kyphotic deformity associated with SAPHO syndrome successfully treated with three-stage correction surgery combined with C7 vertebral column resection: a technical case report. ⁶¹	Funayama T...Yamazaki M	32946068	2021
31	Old and New Drugs for the Management of Bone Disorders in CKD. ⁶¹	Komaba H...Fukagawa M	33386480	2021
32	Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome. ⁶¹	You H...He W	33392854	2021
33	Comparative analysis and differentiation between SAPHO syndrome and spondyloarthropathies using whole-spine MRI. ⁶¹	Zhang LH...Yuan HS	33451718	2021
34	Retrieval of foreign body from maxillary sinus through extraction socket. ⁶¹	Dadhich A...Nilesh K	33462029	2021
35	Similarities and Differences between Clavicular Bacterial Osteomyelitis and Nonbacterial Osteitis: Comparisons of 327 Reported Cases. ⁶¹	Jiang N...Yu B	33575360	2021
36	Tonsillitis as a possible predisposition to synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. ⁶¹	Xiang Y...Li C	33502120	2021
37	Clinical and imaging characteristics of osteitis condensans ilii as compared with axial spondyloarthritis. ⁶¹	Poddubnyy D...Hermann KGA	32447391	2020
38	Toll-like receptor 10 rs10004195 variation may be protective against Bacillus Calmette-Guérin osteitis after newborn vaccination. ⁶¹	Korppi M...He Q	33314255	2020
39	Thinking of Unilateral Osteitis Condensans Ilii in the Emergency Room: Case of a Young Pregnant Female with Back Pain. ⁶¹	Sheikh S...Baig MA	33397066	2020
40	Adult female patient with osteitis pubis and pelvic instability requiring surgery: A case report. ⁶¹	Nasrallah K...Liebergall M	33163608	2020
41	[Possible applications of free microsurgical fibula transplantation in the reconstruction of complex bone defects in the extremities: review of the literature and case series]. ⁶¹	Sauerbier M...Kuz N	32820485	2020
42	Imaging of Joints and Bones in Autoinflammation. ⁶¹	Ziegeler K...Hermann KG	33348664	2020
43	Atteinte osseuse axiale de la sarcoïdose. ⁶¹	Escoda T...Granel B	32868118	2020
44	Treatment of pathological fractures due to brown tumours in a patient with hyperparathyroidism and lack of parafibromin expression - A case report. ⁶¹	Wasiak M...Wasilewski P	33204800	2020
45	The Diagnosis and Treatment of Adult Patients with SAPHO Syndrome: Controversies Revealed in a Multidisciplinary International Survey of Physicians. ⁶¹	Furer V...Elkayam O	32974863	2020
46	Osteitis in Systemic Sclerosis: a nationwide case-control retrospective study (SCLEROS Study). ⁶¹	Cosse C...Chaigne B	33278067	2020
47	Evaluation of the effects of intra-alveolar irrigation with clindamycin, rifampicin and sterile saline in alveolar osteitis treatment. ⁶¹	Cebi AT	31991214	2020
48	The effects of photobiomodulation therapy for treatment of alveolar osteitis (Dry Socket): Systematic review and meta-analysis. ⁶¹	Shafaee H...Rangrazi A	32919077	2020
49	Mandibular sterile osteitis as a manifestation of synovitis, acne, pustulosis, hyperostosis, osteitis syndrome: a literature review. ⁶¹	Klein C...Lipsker D	33331027	2020
50	18F-Sodium Fluoride PET/CT Findings in Osteitis Condensans Ilii. ⁶¹	Usmani S...Al Kandari F	33181740	2020

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Genes for Bone Inflammation Disease

Genes related to Bone Inflammation Disease (0 elite genes):

(show top 50) (show all 83)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	15.41	DISEASES inferred ¹⁵ ¹⁵
2	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	13.39	DISEASES inferred ¹⁵ ¹⁵
3	H2AC18	H2A Clustered Histone 18	Protein Coding	12.08	DISEASES inferred ¹⁵ ¹⁵
4	MIR140	MicroRNA 140	RNA Gene	11.69	DISEASES inferred ¹⁵ ¹⁵
5	SERPINA3	Serpin Family A Member 3	Protein Coding	11.52	DISEASES inferred ¹⁵ ¹⁵
6	MIR155	MicroRNA 155	RNA Gene	11.2	DISEASES inferred ¹⁵ ¹⁵
7	MIR146A	MicroRNA 146a	RNA Gene	10.97	DISEASES inferred ¹⁵ ¹⁵
8	MIR223	MicroRNA 223	RNA Gene	10.32	DISEASES inferred ¹⁵ ¹⁵
9	TNF	Tumor Necrosis Factor	Protein Coding	10.28	DISEASES inferred ¹⁵
10	MIR142	MicroRNA 142	RNA Gene	10.18	DISEASES inferred ¹⁵ ¹⁵
11	IL1B	Interleukin 1 Beta	Protein Coding	9.97	DISEASES inferred ¹⁵
12	IL6	Interleukin 6	Protein Coding	9.96	DISEASES inferred ¹⁵
13	MIR34A	MicroRNA 34a	RNA Gene	9.96	DISEASES inferred ¹⁵ ¹⁵
14	CRP	C-Reactive Protein	Protein Coding	9.74	DISEASES inferred ¹⁵
15	MIR21	MicroRNA 21	RNA Gene	9.69	DISEASES inferred ¹⁵ ¹⁵
16	IL17A	Interleukin 17A	Protein Coding	9.61	DISEASES inferred ¹⁵
17	ACAN	Aggrecan	Protein Coding	9.45	DISEASES inferred ¹⁵
18	MIR126	MicroRNA 126	RNA Gene	9.44	DISEASES inferred ¹⁵ ¹⁵
19	CD4	CD4 Molecule	Protein Coding	9.42	DISEASES inferred ¹⁵
20	MIR125A	MicroRNA 125a	RNA Gene	9.33	DISEASES inferred ¹⁵ ¹⁵
21	IL10	Interleukin 10	Protein Coding	9.32	DISEASES inferred ¹⁵
22	MMP13	Matrix Metallopeptidase 13	Protein Coding	9.28	DISEASES inferred ¹⁵
23	MIR17	MicroRNA 17	RNA Gene	9.23	DISEASES inferred ¹⁵ ¹⁵
24	MIR199A1	MicroRNA 199a-1	RNA Gene	9.14	DISEASES inferred ¹⁵ ¹⁵
25	MMP3	Matrix Metallopeptidase 3	Protein Coding	9.11	DISEASES inferred ¹⁵
26	TNFSF11	TNF Superfamily Member 11	Protein Coding	9.09	DISEASES inferred ¹⁵
27	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	9.02	DISEASES inferred ¹⁵
28	IL4	Interleukin 4	Protein Coding	8.92	DISEASES inferred ¹⁵
29	MIR24-1	MicroRNA 24-1	RNA Gene	8.92	DISEASES inferred ¹⁵ ¹⁵
30	MIR30B	MicroRNA 30b	RNA Gene	8.89	DISEASES inferred ¹⁵ ¹⁵
31	CD8A	CD8a Molecule	Protein Coding	8.84	DISEASES inferred ¹⁵
32	ADAMTS5	ADAM Metallopeptidase With Thrombospondin Type 1 Motif 5	Protein Coding	8.8	DISEASES inferred ¹⁵
33	MIR30A	MicroRNA 30a	RNA Gene	8.8	DISEASES inferred ¹⁵ ¹⁵
34	IL2	Interleukin 2	Protein Coding	8.76	DISEASES inferred ¹⁵
35	MIR125B1	MicroRNA 125b-1	RNA Gene	8.72	DISEASES inferred ¹⁵ ¹⁵
36	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	8.67	DISEASES inferred ¹⁵
37	MIR210	MicroRNA 210	RNA Gene	8.62	DISEASES inferred ¹⁵ ¹⁵
38	FOXP3	Forkhead Box P3	Protein Coding	8.6	DISEASES inferred ¹⁵
39	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	8.6	DISEASES inferred ¹⁵
40	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	8.59	DISEASES inferred ¹⁵
41	TLR4	Toll Like Receptor 4	Protein Coding	8.57	DISEASES inferred ¹⁵
42	HLA-DRB1	Major Histocompatibility Complex, Class II, DR Beta 1	Protein Coding	8.56	DISEASES inferred ¹⁵
43	MIR483	MicroRNA 483	RNA Gene	8.53	DISEASES inferred ¹⁵ ¹⁵
44	IL1A	Interleukin 1 Alpha	Protein Coding	8.53	DISEASES inferred ¹⁵
45	PRTN3	Proteinase 3	Protein Coding	8.52	DISEASES inferred ¹⁵
46	ALB	Albumin	Protein Coding	8.5	DISEASES inferred ¹⁵
47	IL18	Interleukin 18	Protein Coding	8.5	DISEASES inferred ¹⁵
48	MIR196A1	MicroRNA 196a-1	RNA Gene	8.49	DISEASES inferred ¹⁵ ¹⁵
49	COMP	Cartilage Oligomeric Matrix Protein	Protein Coding	8.47	DISEASES inferred ¹⁵
50	MIR455	MicroRNA 455	RNA Gene	8.46	DISEASES inferred ¹⁵ ¹⁵

Sources

Variations for Bone Inflammation Disease

Sources

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Sources

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 32)

#	Super pathways	Score	Top Affiliating Genes
1	Allograft rejection ³⁶ ¹ Show member pathways Antigen processing and presentation ³⁶ Asthma ³⁶ Autoimmune thyroid disease ³⁶ CTL Mediated Apoptosis ⁶³ Graft-versus-host disease ³⁶ Intestinal immune network for IgA production ³⁶ THC Differentiation Pathway ⁶³ Type I diabetes mellitus ³⁶ Viral myocarditis ³⁶	12.76	TNF IL6 IL1B IL17A ICOSLG CD4
2	T cell receptor signaling pathway ³⁶ Show member pathways PD-L1 expression and PD-1 checkpoint pathway in cancer ³⁶ T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.55	TNF IL6 IL1B IL17A CD4
3	Th17 cell differentiation ³⁶ Show member pathways IL-22 Pathway ⁶³ Immune response IL-22 signaling pathway ²³ Inflammatory bowel disease ³⁶ Th1 and Th2 cell differentiation ³⁶	12.54	TNF IL6 IL1B IL17A CD4
4	Immune response IL-23 signaling pathway ²³ Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶³ Development Angiopoietin - Tie2 signaling ²³ Development PDGF signaling via STATs and NF-kB ²³ IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²³ Rac1/Pak1/p38/MMP-2 pathway ¹	12.53	TNF IL6 IL1B IL17A CD4
5	IL-17 Family Signaling Pathways ⁶⁴ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁶ Interleukin-17 signaling ⁶⁵ Mucin expression in CF via IL-6, IL-17 signaling pathways ²³	12.28	TNF IL6 IL1B IL17A
6	Folate Metabolism ¹ Show member pathways Selenium Micronutrient Network ¹ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.19	TNF SERPINA3 IL6 IL1B CRP
7	Alzheimers Disease ¹	12.07	TNF MIR21 MIR125A IL1B
8	Yersinia infection ³⁶	12.02	TNF IL6 IL1B CD4
9	Spinal Cord Injury ¹	11.94	TNF IL6 IL1B ACAN
10	Interleukin-4 and 13 signaling ⁶⁵	11.88	TNF IL6 IL1B IL17A
11	Hematopoietic cell lineage ³⁶	11.81	TNF IL6 IL1B CD4
12	Rheumatoid arthritis ³⁶	11.76	TNF IL6 IL1B IL17A
13	Th17 Differentiation Pathway ⁶⁴ Show member pathways IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴	11.74	IL6 IL1B IL17A CD4
14	Pertussis ³⁶	11.71	TNF IL6 IL1B
15	MicroRNAs in cancer ³⁶	11.66	MIR34A MIR223 MIR21 MIR155 MIR146A MIR126
16	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²³	11.62	TNF IL6 IL1B
17	Lung fibrosis ¹	11.61	TNF IL6 IL1B
18	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.57	TNF IL6 IL1B CD4
19	Legionellosis ³⁶	11.56	TNF IL6 IL1B
20	Malaria ³⁶	11.5	TNF IL6 IL1B
21	Interleukin-10 signaling ⁶⁵	11.49	TNF IL6 IL1B
22	IgA-Producing B Cells in the Intestine ⁶⁴	11.49	TNF IL6 ICOSLG CCR6
23	Innate Lymphoid Cell Differentiation Pathways ⁶⁴	11.46	TNF IL1B IL17A CD4 CCR6
24	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	11.45	TNF IL6 IL1B
25	African trypanosomiasis ³⁶	11.32	TNF IL6 IL1B
26	IL-10 Pathway ⁶³	11.29	TNF IL6 IL1B
27	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹	11.23	TNF IL6 IL1B IL17A CD4
28	Antifolate resistance ³⁶	11.22	TNF IL6 IL1B
29	Development and heterogeneity of the ILC family ¹	11.13	TNF IL6 IL1B IL17A
30	Cytokines and Inflammatory Response ¹	11.02	TNF IL6 IL1B CD4
31	Overview of nanoparticle effects ¹	10.89	TNF IL6 CRP
32	EV release from cardiac cells and their functional effects ¹	10.6	TNF MIR126

Sources

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular exosome	GO:0070062	9.91	SERPINA3 MIR34A MIR223 MIR21 MIR155 MIR146A
2	external side of plasma membrane	GO:0009897	9.55	TNF IL17A ICOSLG CD4 CCR6
3	extracellular space	GO:0005615	9.47	TNF SERPINA3 MIR223 MIR21 MIR155 MIR146A
4	extracellular vesicle	GO:1903561	9.26	MIR34A MIR21 MIR126 MIR125A

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 52)

#	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:0006955	10.11	TNF IL6 IL1B IL17A CD4 CCR6
2	inflammatory response	GO:0006954	10.08	TNF SERPINA3 IL6 IL1B IL17A CRP
3	cytokine-mediated signaling pathway	GO:0019221	10.04	TNF IL6 IL1B IL17A CD4
4	positive regulation of ERK1 and ERK2 cascade	GO:0070374	10.01	TNF MIR21 MIR126 CD4
5	positive regulation of protein phosphorylation	GO:0001934	10	TNF MIR21 IL1B CD4
6	negative regulation of inflammatory response	GO:0050728	9.97	MIR223 MIR155 MIR146A MIR142 MIR126
7	negative regulation of angiogenesis	GO:0016525	9.95	MIR34A MIR21 MIR146A MIR125A
8	cellular response to hypoxia	GO:0071456	9.93	MIR34A MIR155 MIR146A MIR140 MIR126
9	defense response to Gram-positive bacterium	GO:0050830	9.92	TNF IL6 IL17A CRP
10	positive regulation of interleukin-6 production	GO:0032755	9.91	TNF IL6 IL1B IL17A
11	regulation of insulin secretion	GO:0050796	9.88	TNF IL6 IL1B
12	positive regulation of T cell proliferation	GO:0042102	9.88	IL6 IL1B CD4
13	positive regulation of inflammatory response	GO:0050729	9.88	TNF MIR21 MIR155 MIR126 IL1B
14	cellular response to lipopolysaccharide	GO:0071222	9.88	TNF MIR21 MIR146A MIR140 IL6 IL1B
15	positive regulation of interleukin-8 production	GO:0032757	9.87	TNF IL6 IL1B
16	humoral immune response	GO:0006959	9.87	TNF IL6 CCR6
17	negative regulation of gene expression	GO:0010629	9.87	TNF MIR34A MIR21 MIR155 MIR146A MIR140
18	positive regulation of interleukin-1 beta production	GO:0032731	9.86	TNF IL6 IL17A
19	positive regulation of epithelial to mesenchymal transition	GO:0010718	9.85	MIR21 IL6 IL1B
20	negative regulation of vascular smooth muscle cell proliferation	GO:1904706	9.85	MIR34A MIR223 MIR140
21	cellular response to virus	GO:0098586	9.85	MIR21 MIR146A IL6
22	negative regulation of endothelial cell proliferation	GO:0001937	9.84	TNF MIR21 MIR146A
23	negative regulation of NIK/NF-kappaB signaling	GO:1901223	9.83	MIR223 MIR21 MIR146A
24	acute-phase response	GO:0006953	9.83	SERPINA3 IL6 CRP
25	positive regulation of sprouting angiogenesis	GO:1903672	9.81	MIR155 MIR126 MIR125A
26	negative regulation of cytokine production involved in inflammatory response	GO:1900016	9.81	MIR155 MIR146A MIR140 MIR125A
27	positive regulation of activated T cell proliferation	GO:0042104	9.8	MIR21 MIR155 ICOSLG
28	negative regulation of neurogenesis	GO:0050768	9.79	TNF IL6 IL1B
29	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GO:1903589	9.79	MIR21 MIR146A MIR126
30	positive regulation of glial cell proliferation	GO:0060252	9.77	TNF IL6 IL1B
31	negative regulation of interleukin-6 production	GO:0032715	9.77	TNF MIR155 MIR146A MIR140 MIR125A
32	positive regulation of leukocyte adhesion to vascular endothelial cell	GO:1904996	9.76	TNF MIR21 IL6
33	negative regulation of vascular endothelial growth factor production	GO:1904046	9.76	MIR34A MIR146A MIR140 MIR125A
34	negative regulation of leukocyte adhesion to vascular endothelial cell	GO:1904995	9.74	MIR155 MIR146A MIR125A
35	negative regulation of vascular wound healing	GO:0061044	9.73	TNF MIR34A MIR155
36	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.73	TNF MIR21 IL6 IL17A
37	negative regulation of lipid storage	GO:0010888	9.72	TNF IL6 CRP
38	negative regulation of amyloid-beta clearance	GO:1900222	9.71	TNF MIR34A
39	regulation of establishment of endothelial barrier	GO:1903140	9.71	TNF IL1B
40	negative regulation of regulatory T cell differentiation	GO:0045590	9.7	MIR21 MIR155
41	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.7	MIR21 IL6
42	negative regulation of bicellular tight junction assembly	GO:1903347	9.7	TNF MIR155 MIR142
43	negative regulation of necrotic cell death	GO:0060547	9.68	MIR223 MIR155
44	positive regulation of fever generation	GO:0031622	9.68	TNF IL1B
45	negative regulation of intracellular signal transduction	GO:1902532	9.67	MIR34A MIR146A
46	sequestering of triglyceride	GO:0030730	9.67	TNF IL1B
47	vascular endothelial growth factor production	GO:0010573	9.67	TNF IL6 IL1B
48	positive regulation of calcidiol 1-monooxygenase activity	GO:0060559	9.64	TNF IL1B
49	gene silencing by miRNA	GO:0035195	9.61	MIR34A MIR223 MIR21 MIR155 MIR146A MIR142
50	negative regulation of vascular associated smooth muscle cell migration	GO:1904753	9.56	MIR34A MIR223 MIR21 MIR140

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	9.56	TNF IL6 IL1B IL17A
2	mRNA 3'-UTR binding	GO:0003730	9.5	MIR34A MIR21 MIR146A MIR142 MIR140 MIR126
3	RNA polymerase II complex binding	GO:0000993	9.33	MIR140 MIR126 MIR125A
4	mRNA binding involved in posttranscriptional gene silencing	GO:1903231	9.28	MIR34A MIR223 MIR21 MIR155 MIR146A MIR142

Sources

Sources for Bone Inflammation Disease

¹ BioSystems

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⁵⁷ OMIM® (Updated 05-Mar-2021)

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⁶¹ PubMed

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⁷⁴ Wikipedia