Bone Inflammation Disease

Categories: Bone diseases

Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease 12 15
Osteitis 12 44 15 71
Inflammatory Disorder of Bone 12
Bone Inflammatory Disease 12


External Ids:

Disease Ontology 12 DOID:3342
MeSH 44 D010000
SNOMED-CT 67 274144001
UMLS 71 C0029400

Summaries for Bone Inflammation Disease

Disease Ontology : 12 A bone disease that results in inflammation of the located in bone.

MalaCards based summary : Bone Inflammation Disease, also known as osteitis, is related to osteomyelitis and spondyloarthropathy 1. An important gene associated with Bone Inflammation Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Allograft rejection and T cell receptor signaling pathway. The drugs Chlorhexidine and Zoledronic Acid have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and prostate.

Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 990)
# Related Disease Score Top Affiliating Genes
1 osteomyelitis 32.4 TNF IL6 IL1B CRP
2 spondyloarthropathy 1 32.3 TNF IL6 IL17A ICOSLG CRP CCR6
3 arthritis 32.3 TNF IL6 IL1B IL17A CRP CCR6
4 synovitis 32.0 TNF IL6 IL1B CRP ACAN
5 spondylitis 31.6 TNF IL6 IL1B IL17A ICOSLG CRP
6 syphilis 31.5 SERPINA3 IL17A CRP CD4 CCR6
7 bone disease 31.5 TNF IL6 IL1B IL17A CCR6 ACAN
8 chronic recurrent multifocal osteomyelitis 31.3 TNF IL6 IL1B CRP
9 bone resorption disease 31.3 TNF SERPINA3 MIR142 MIR140 IL6 IL1B
10 enthesopathy 31.3 TNF CRP CCR6 ACAN
11 rheumatoid arthritis 31.2 TNF MIR155 MIR146A IL6 IL1B IL17A
12 spondyloarthropathy 31.2 TNF IL6 IL1B IL17A
13 back pain 31.2 IL6 IL1B
14 typhoid fever 31.2 TNF IL6 IL1B CRP CCR6
15 pustulosis of palm and sole 31.1 TNF IL17A CRP CCR6
16 tenosynovitis 31.1 TNF IL6 IL1B CRP CD4
17 pulpitis 31.1 TNF IL6 IL1B CCR6
18 psoriatic arthritis 31.1 TNF MIR146A IL6 IL1B IL17A CRP
19 brucellosis 31.0 TNF IL6 IL17A CRP
20 osteoporosis 31.0 TNF MIR21 MIR140 IL6 IL1B IL17A
21 osteoarthritis 31.0 TNF IL6 IL1B IL17A CRP ACAN
22 psoriasis 31.0 TNF MIR21 MIR146A MIR142 IL6 IL1B
23 meningitis 31.0 TNF IL6 IL1B IL17A CRP
24 ankylosis 30.9 TNF IL17A CCR6
25 tonsillitis 30.8 TNF IL6 IL1B
26 pneumonia 30.8 TNF IL6 IL1B IL17A CRP
27 tertiary syphilis 30.8 TNF CRP CD4
28 histiocytosis 30.8 TNF SERPINA3 IL17A CCR6
29 prostatitis 30.8 TNF SERPINA3 IL6 IL1B IL17A
30 toxic shock syndrome 30.8 TNF IL6 IL1B CRP
31 leprosy 3 30.8 TNF IL6 IL1B IL17A CD4 CCR6
32 pyoderma 30.8 TNF IL1B CCR6
33 tetanus 30.8 TNF IL6 IL1B CRP
34 kidney disease 30.7 TNF SERPINA3 MIR223 MIR21 MIR155 MIR126
35 chronic kidney disease 30.7 TNF SERPINA3 MIR223 MIR21 MIR126 IL6
36 periodontitis 30.7 TNF SERPINA3 MIR21 MIR146A MIR125A IL6
37 otitis externa 30.7 IL6 CRP CD4
38 cellulitis 30.7 TNF IL6 CRP CD4 CCR6
39 arthropathy 30.7 TNF IL6 IL1B CRP ACAN
40 myositis 30.7 TNF SERPINA3 IL6 IL1B IL17A ICOSLG
41 appendicitis 30.7 TNF IL6 IL1B IL17A CRP
42 granulomatosis with polyangiitis 30.7 TNF MIR142 ICOSLG CRP CD4 CCR6
43 dermatitis 30.7 TNF IL6 IL1B IL17A CD4 CCR6
44 orchitis 30.7 TNF IL6 IL1B H2AC18 CRP CD4
45 reactive arthritis 30.7 TNF IL6 IL1B IL17A CRP CCR6
46 actinomycosis 30.7 TNF IL6 IL1B H2AC18 CRP CD4
47 iritis 30.7 TNF IL6 IL17A CRP CD4 CCR6
48 otitis media 30.7 TNF IL6 IL1B IL17A CRP
49 salmonellosis 30.7 TNF IL6 IL1B IL17A CD4 CCR6
50 lymphadenitis 30.7 TNF SERPINA3 IL1B ICOSLG CRP CD4

Graphical network of the top 20 diseases related to Bone Inflammation Disease:

Diseases related to Bone Inflammation Disease

Symptoms & Phenotypes for Bone Inflammation Disease

Drugs & Therapeutics for Bone Inflammation Disease

Drugs for Bone Inflammation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 66)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Chlorhexidine Approved, Vet_approved Phase 4 55-56-1 9552079 2713
Zoledronic Acid Approved Phase 4 118072-93-8 68740
Pamidronate Approved Phase 4 40391-99-9 4674
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
6 Calcium, Dietary Phase 4
7 Pharmaceutical Solutions Phase 4
8 Chlorhexidine gluconate Phase 4
9 Hormones Phase 4
10 Nutrients Phase 4
11 Micronutrients Phase 4
12 Trace Elements Phase 4
13 Vitamins Phase 4
14 Diphosphonates Phase 4
15 Calciferol Phase 4
Calcium Nutraceutical Phase 4 7440-70-2 271
Etidronic acid Approved Phase 3 2809-21-4, 7414-83-7 3305
Risedronate Approved, Investigational Phase 3 105462-24-6 5245
19 Antibiotics, Antitubercular Phase 3
20 Anti-Bacterial Agents Phase 3
21 Anti-Infective Agents Phase 3
22 calcium channel blockers Phase 3
Hydrogen peroxide Approved, Vet_approved Phase 2 7722-84-1 784
Hyaluronic acid Approved, Vet_approved Phase 2 9004-61-9 53477741
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
27 Octenidine Investigational Phase 2 71251-02-0
28 Anti-Inflammatory Agents Phase 2
29 Gastrointestinal Agents Phase 2
30 Hormone Antagonists Phase 2
31 BB 1101 Phase 2
32 glucocorticoids Phase 2
33 HIV Protease Inhibitors Phase 2
34 Antineoplastic Agents, Hormonal Phase 2
35 Dexamethasone 21-phosphate Phase 2
protease inhibitors Phase 2
37 Antiemetics Phase 2
Tetracycline Approved, Vet_approved 60-54-8 5353990
Menthol Approved 2216-51-5 16666
Silicon Approved, Investigational 7440-21-3 4082203
Peppermint Approved
Peppermint oil Approved, Investigational 8006-90-4
Tocopherol Approved, Investigational 1406-66-2
Sorbitol Approved 50-70-4 5780
Aspirin Approved, Vet_approved 50-78-2 2244
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
Vitamin C Approved, Nutraceutical 50-81-7 5785 54670067
48 Tocotrienol Investigational 6829-55-6
49 Anesthetics
50 Cardiac Glycosides

Interventional clinical trials:

(show all 29)
# Name Status NCT ID Phase Drugs
1 Efficacy of DC071 Mouthwash (0.2% Chlorhexidine Digluconate) in Peri-surgical Care for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
2 An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies Completed NCT00740129 Phase 4 Zoledronic Acid
3 Bisphosphonate Therapy for Osteogenesis Imperfecta Completed NCT00159419 Phase 4 Alendronate;Pamidronate
4 A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China Completed NCT00774020 Phase 4 Zoledronic acid
5 Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation Completed NCT00668200 Phase 4 Reclast (ZOL446, zoledronic acid)
6 Open Label Study to Describe the Effect of Tocilizumab in Combination With MTX in the Evolution of Articular Damage (Synovitis/Osteitis and Erosions) Evaluated by MRI in the Hand of Patients With Moderate to Severe Rheumatoid Arthritis (RA) and Inadequate Response to Non-biological DMARDs Withdrawn NCT01878318 Phase 4 methotrexate;tocilizumab [RoActemra/Actemra]
7 Antibiotic Efficacy in Third Molar Surgery Completed NCT00118820 Phase 3 IV Preoperative antibiotic or placebo
8 Randomized, Double-blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observational Period Completed NCT00051636 Phase 3 Zoledronic Acid;Risedronate;Placebo to Risedronate;Placebo to Zoledronic Acid
9 Randomized, Double-Blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observation Period Completed NCT00103740 Phase 3 zoledronic acid;placebo to zoledronic acid;Risedronate;Placebo to risedronate;Calcium and vitamin D supplements
10 A 6-Month, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Alendronate 280-mg Oral Buffered Solution Once Weekly in Patients With Paget's Disease of Bone Completed NCT00480662 Phase 3 alendronate
11 Multi-centre, Open-label, First-in-man Study of Adult Patients Suffered From Alveolar Osteitis Treated Using Stomatological Tamponade Contipro Completed NCT04091399 Phase 2 Stamatological tamponade Contipro
12 Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial Recruiting NCT03606980 Phase 2 Dexamethasone Sodium Phosphate
13 Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders Unknown status NCT00403598
14 Allogenic Vascularized Knee and Femur Transplantation Clinical Evaluation Unknown status NCT01133145
15 Comparison of Three Treatments for Lower Extremity Apophysitis Unknown status NCT01826071
16 Pressure Sore-related Osteitis Treated by Flap Coverage and Short Antibiotic Regimen Completed NCT03964818
17 A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery Completed NCT03494972 Tetracyclin ointment
18 Effect of Concentrated Growth Factors on Frequency of Alveolar Osteitis Following Partially Erupted Mandibular Third Molar Surgery: A Randomized Controlled Clinical Study Completed NCT04151147
19 Effect of NBF Gingival Gel Application in Controlling Post-surgical Complications After Impacted Lower Third Molar Surgery Completed NCT03641482 NBF
20 Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial Completed NCT03960086
21 Genetic Study of Families Affected by Paget's Disease of Bone Completed NCT00747994
22 Use of 18F-Fluoride Positron Emission Tomography in the Assessment and Evaluation of Therapy in Monostotic Paget's Disease of Bone Completed NCT00306046 Bisphosphonate treatment
23 Sodium Risedronate 17.5 mg Tablets Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) - 48-week Surveillance - Completed NCT02106455 Sodium risedronate
24 Characterizing Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis (SAPHO) With 68Ga-FAPI PET/CT Recruiting NCT04596462 Early Phase 1 68Ga-FAPI
25 Investigation of Pathophysiology of Angiogenesis and Osteogenesis in Paget's Disease of Bone Recruiting NCT02802384
26 Characterization of Familial Myopathy and Paget Disease of Bone Recruiting NCT01353430
27 Clinical Investigation of the Efficacy of CGF (Concentrated Growth Factor) and Ozone in the Treatment of Alveolar Osteitis Active, not recruiting NCT04507009
28 Evaluation of Platelet Rich Fibrin Use in the Treatment of Dry Socket. Active, not recruiting NCT04476121 Nipas application
29 Management of Lower Limb Apophysitis: A Cross-sectional Study on Long-term Impact on Health Status Not yet recruiting NCT04313621

Search NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

Genetic Tests for Bone Inflammation Disease

Anatomical Context for Bone Inflammation Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Inflammation Disease:


MalaCards organs/tissues related to Bone Inflammation Disease:

Bone, Bone Marrow, Prostate, Spinal Cord, Neutrophil, Eye, Whole Blood

Publications for Bone Inflammation Disease

Articles related to Bone Inflammation Disease:

(show top 50) (show all 4576)
# Title Authors PMID Year
Effect of platelet-rich fibrin on the control of alveolar osteitis, pain, trismus, soft tissue healing, and swelling following mandibular third molar surgery: an updated systematic review and meta-analysis. 61
32950350 2021
A Rare Case of Nontraumatic Thoracic Compression Fracture in a 28-Year-Old Man. 61
32618750 2021
The effectiveness of treatments for patients with SAPHO syndrome: a follow-up study of 24 cases from a single center and review of literature. 61
32789818 2021
Application of propolis extract, nanovitamin C and nanovitamin E to prevent alveolar osteitis after impacted lower third molar surgery. A randomized, double-blind, split-mouth, pilot study. 61
33609021 2021
Interleukin 17F gene variations showed no association with BCG osteitis risk after newborn vaccination. 61
32946631 2021
The preventive effect of medicinal herbal extract and gelatin sponge on alveolar osteitis: An in vivo micro-computed tomography and immunohistochemical analysis in rats. 61
33316659 2021
Osteitis fibrosa cystica von Recklinghausen. 61
33555577 2021
Crosstalk Between Mucosal Inflammation and Bone Metabolism in Chronic Rhinosinusitis. 61
32877964 2021
Influence of computed tomographic dimensions of the nasopharynx on middle ear effusion and inflammation in pugs and French bulldogs with brachycephalic airway syndrome. 61
33595152 2021
Postoperative effects of intra-alveolar application of 0.2% chlorhexidine or 1% hyaluronic acid bioadhesive gels after mandibular third molar extraction: a double-blind randomized controlled clinical trial. 61
32833133 2021
Intestinal ulcers induced by intravesical bacillus Calmette-Guérin therapy. 61
33492192 2021
Contrast-enhanced T1-weighted Dixon water- and fat-only images to assess osteitis and erosions according to RAMRIS in hands of patients with early rheumatoid arthritis. 61
33583754 2021
Lobular panniculitis associated with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. 61
32840874 2021
Sinus and osteitis 7 years after a sacrospinous fixation. 61
33409578 2021
Dietary habits in Japanese patients with palmoplantar pustulosis. 61
33404125 2021
Risk factors for post-tooth extraction complications in HIV-infected patients: A retrospective study. 61
33518617 2021
Coronectomy of Mandibular Third Molars: A Systematic Literature Review and Case Studies. 61
33486775 2021
Advances in the Knowledge of the Underlying Airway Remodeling Mechanisms in Chronic Rhinosinusitis Based on the Endotypes: A Review. 61
33477617 2021
Adult-onset Woakes' syndrome: a rare entity. 61
33431532 2021
Baricitinib inhibits structural joint damage progression in patients with rheumatoid arthritis-a comprehensive review. 61
33397481 2021
Predictors of joint damage progression and stringent remission in patients with established rheumatoid arthritis in clinical remission. 61
32929463 2021
Serum interleukin-23 protects, whereas methotrexate treatment stimulates selected components of the metabolic syndrome in patients with SAPHO syndrome. 61
33488864 2021
Osteitis condensans ilii in a patient with ulcerative colitis: a mimic of ankylosing spondylitis or non-radiographic axial spondyloarthritis. 61
33250009 2021
Tripterygium wilfordii Hook F. in the treatment of synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a clinical trial. 61
33389313 2021
Disease activity in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome: the utility of the SPARCC MRI scoring system for assessment of axial spine involvement. 61
33427614 2021
Tofacitinib for the Treatment of Nail Lesions and Palmoplantar Pustulosis in Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome. 61
32997094 2021
Impact of baseline clinical and radiological features on outcome of chronic rhinosinusitis in granulomatosis with polyangiitis. 61
33430923 2021
Rituximab plus belimumab in non-infectious refractory cryoglobulinemia vasculitis: A pilot study. 61
33248866 2021
Ankle arthritis - an important signpost in rheumatologic practice. 61
33097958 2021
Severe, rigid cervical kyphotic deformity associated with SAPHO syndrome successfully treated with three-stage correction surgery combined with C7 vertebral column resection: a technical case report. 61
32946068 2021
Old and New Drugs for the Management of Bone Disorders in CKD. 61
33386480 2021
Serum Sp17 Autoantibody Serves as a Potential Specific Biomarker in Patients with SAPHO Syndrome. 61
33392854 2021
Comparative analysis and differentiation between SAPHO syndrome and spondyloarthropathies using whole-spine MRI. 61
33451718 2021
Retrieval of foreign body from maxillary sinus through extraction socket. 61
33462029 2021
Similarities and Differences between Clavicular Bacterial Osteomyelitis and Nonbacterial Osteitis: Comparisons of 327 Reported Cases. 61
33575360 2021
Tonsillitis as a possible predisposition to synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome. 61
33502120 2021
Clinical and imaging characteristics of osteitis condensans ilii as compared with axial spondyloarthritis. 61
32447391 2020
Toll-like receptor 10 rs10004195 variation may be protective against Bacillus Calmette-Guérin osteitis after newborn vaccination. 61
33314255 2020
Thinking of Unilateral Osteitis Condensans Ilii in the Emergency Room: Case of a Young Pregnant Female with Back Pain. 61
33397066 2020
Adult female patient with osteitis pubis and pelvic instability requiring surgery: A case report. 61
33163608 2020
[Possible applications of free microsurgical fibula transplantation in the reconstruction of complex bone defects in the extremities: review of the literature and case series]. 61
32820485 2020
Imaging of Joints and Bones in Autoinflammation. 61
33348664 2020
Atteinte osseuse axiale de la sarcoïdose. 61
32868118 2020
Treatment of pathological fractures due to brown tumours in a patient with hyperparathyroidism and lack of parafibromin expression - A case report. 61
33204800 2020
The Diagnosis and Treatment of Adult Patients with SAPHO Syndrome: Controversies Revealed in a Multidisciplinary International Survey of Physicians. 61
32974863 2020
Osteitis in Systemic Sclerosis: a nationwide case-control retrospective study (SCLEROS Study). 61
33278067 2020
Evaluation of the effects of intra-alveolar irrigation with clindamycin, rifampicin and sterile saline in alveolar osteitis treatment. 61
31991214 2020
The effects of photobiomodulation therapy for treatment of alveolar osteitis (Dry Socket): Systematic review and meta-analysis. 61
32919077 2020
Mandibular sterile osteitis as a manifestation of synovitis, acne, pustulosis, hyperostosis, osteitis syndrome: a literature review. 61
33331027 2020
18F-Sodium Fluoride PET/CT Findings in Osteitis Condensans Ilii. 61
33181740 2020

Variations for Bone Inflammation Disease

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
12.55 TNF IL6 IL1B IL17A CD4
Show member pathways
12.54 TNF IL6 IL1B IL17A CD4
Show member pathways
12.53 TNF IL6 IL1B IL17A CD4
Show member pathways
12.28 TNF IL6 IL1B IL17A
Show member pathways
7 12.07 TNF MIR21 MIR125A IL1B
8 12.02 TNF IL6 IL1B CD4
9 11.94 TNF IL6 IL1B ACAN
10 11.88 TNF IL6 IL1B IL17A
11 11.81 TNF IL6 IL1B CD4
12 11.76 TNF IL6 IL1B IL17A
Show member pathways
11.74 IL6 IL1B IL17A CD4
14 11.71 TNF IL6 IL1B
15 11.66 MIR34A MIR223 MIR21 MIR155 MIR146A MIR126
Show member pathways
11.62 TNF IL6 IL1B
17 11.61 TNF IL6 IL1B
18 11.57 TNF IL6 IL1B CD4
19 11.56 TNF IL6 IL1B
20 11.5 TNF IL6 IL1B
21 11.49 TNF IL6 IL1B
22 11.49 TNF IL6 ICOSLG CCR6
23 11.46 TNF IL1B IL17A CD4 CCR6
24 11.45 TNF IL6 IL1B
25 11.32 TNF IL6 IL1B
26 11.29 TNF IL6 IL1B
Show member pathways
11.23 TNF IL6 IL1B IL17A CD4
28 11.22 TNF IL6 IL1B
29 11.13 TNF IL6 IL1B IL17A
30 11.02 TNF IL6 IL1B CD4
31 10.89 TNF IL6 CRP
32 10.6 TNF MIR126

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 SERPINA3 MIR34A MIR223 MIR21 MIR155 MIR146A
2 external side of plasma membrane GO:0009897 9.55 TNF IL17A ICOSLG CD4 CCR6
3 extracellular space GO:0005615 9.47 TNF SERPINA3 MIR223 MIR21 MIR155 MIR146A
4 extracellular vesicle GO:1903561 9.26 MIR34A MIR21 MIR126 MIR125A

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 10.11 TNF IL6 IL1B IL17A CD4 CCR6
2 inflammatory response GO:0006954 10.08 TNF SERPINA3 IL6 IL1B IL17A CRP
3 cytokine-mediated signaling pathway GO:0019221 10.04 TNF IL6 IL1B IL17A CD4
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 10.01 TNF MIR21 MIR126 CD4
5 positive regulation of protein phosphorylation GO:0001934 10 TNF MIR21 IL1B CD4
6 negative regulation of inflammatory response GO:0050728 9.97 MIR223 MIR155 MIR146A MIR142 MIR126
7 negative regulation of angiogenesis GO:0016525 9.95 MIR34A MIR21 MIR146A MIR125A
8 cellular response to hypoxia GO:0071456 9.93 MIR34A MIR155 MIR146A MIR140 MIR126
9 defense response to Gram-positive bacterium GO:0050830 9.92 TNF IL6 IL17A CRP
10 positive regulation of interleukin-6 production GO:0032755 9.91 TNF IL6 IL1B IL17A
11 regulation of insulin secretion GO:0050796 9.88 TNF IL6 IL1B
12 positive regulation of T cell proliferation GO:0042102 9.88 IL6 IL1B CD4
13 positive regulation of inflammatory response GO:0050729 9.88 TNF MIR21 MIR155 MIR126 IL1B
14 cellular response to lipopolysaccharide GO:0071222 9.88 TNF MIR21 MIR146A MIR140 IL6 IL1B
15 positive regulation of interleukin-8 production GO:0032757 9.87 TNF IL6 IL1B
16 humoral immune response GO:0006959 9.87 TNF IL6 CCR6
17 negative regulation of gene expression GO:0010629 9.87 TNF MIR34A MIR21 MIR155 MIR146A MIR140
18 positive regulation of interleukin-1 beta production GO:0032731 9.86 TNF IL6 IL17A
19 positive regulation of epithelial to mesenchymal transition GO:0010718 9.85 MIR21 IL6 IL1B
20 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.85 MIR34A MIR223 MIR140
21 cellular response to virus GO:0098586 9.85 MIR21 MIR146A IL6
22 negative regulation of endothelial cell proliferation GO:0001937 9.84 TNF MIR21 MIR146A
23 negative regulation of NIK/NF-kappaB signaling GO:1901223 9.83 MIR223 MIR21 MIR146A
24 acute-phase response GO:0006953 9.83 SERPINA3 IL6 CRP
25 positive regulation of sprouting angiogenesis GO:1903672 9.81 MIR155 MIR126 MIR125A
26 negative regulation of cytokine production involved in inflammatory response GO:1900016 9.81 MIR155 MIR146A MIR140 MIR125A
27 positive regulation of activated T cell proliferation GO:0042104 9.8 MIR21 MIR155 ICOSLG
28 negative regulation of neurogenesis GO:0050768 9.79 TNF IL6 IL1B
29 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.79 MIR21 MIR146A MIR126
30 positive regulation of glial cell proliferation GO:0060252 9.77 TNF IL6 IL1B
31 negative regulation of interleukin-6 production GO:0032715 9.77 TNF MIR155 MIR146A MIR140 MIR125A
32 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.76 TNF MIR21 IL6
33 negative regulation of vascular endothelial growth factor production GO:1904046 9.76 MIR34A MIR146A MIR140 MIR125A
34 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.74 MIR155 MIR146A MIR125A
35 negative regulation of vascular wound healing GO:0061044 9.73 TNF MIR34A MIR155
36 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.73 TNF MIR21 IL6 IL17A
37 negative regulation of lipid storage GO:0010888 9.72 TNF IL6 CRP
38 negative regulation of amyloid-beta clearance GO:1900222 9.71 TNF MIR34A
39 regulation of establishment of endothelial barrier GO:1903140 9.71 TNF IL1B
40 negative regulation of regulatory T cell differentiation GO:0045590 9.7 MIR21 MIR155
41 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.7 MIR21 IL6
42 negative regulation of bicellular tight junction assembly GO:1903347 9.7 TNF MIR155 MIR142
43 negative regulation of necrotic cell death GO:0060547 9.68 MIR223 MIR155
44 positive regulation of fever generation GO:0031622 9.68 TNF IL1B
45 negative regulation of intracellular signal transduction GO:1902532 9.67 MIR34A MIR146A
46 sequestering of triglyceride GO:0030730 9.67 TNF IL1B
47 vascular endothelial growth factor production GO:0010573 9.67 TNF IL6 IL1B
48 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.64 TNF IL1B
49 gene silencing by miRNA GO:0035195 9.61 MIR34A MIR223 MIR21 MIR155 MIR146A MIR142
50 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.56 MIR34A MIR223 MIR21 MIR140

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.56 TNF IL6 IL1B IL17A
2 mRNA 3'-UTR binding GO:0003730 9.5 MIR34A MIR21 MIR146A MIR142 MIR140 MIR126
3 RNA polymerase II complex binding GO:0000993 9.33 MIR140 MIR126 MIR125A
4 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.28 MIR34A MIR223 MIR21 MIR155 MIR146A MIR142

Sources for Bone Inflammation Disease

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
70 Tocris
72 UMLS via Orphanet
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