MCID: BNN003
MIFTS: 51

Bone Inflammation Disease

Categories: Bone diseases

Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease 12 15
Osteitis 12 44 15 72
Inflammatory Disorder of Bone 12
Bone Inflammatory Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3342
MeSH 44 D010000
SNOMED-CT 68 44462005
UMLS 72 C0029400

Summaries for Bone Inflammation Disease

Disease Ontology : 12 A bone disease that results in inflammation of the located in bone.

MalaCards based summary : Bone Inflammation Disease, also known as osteitis, is related to osteomyelitis and spondyloarthropathy 1. An important gene associated with Bone Inflammation Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Zoledronic Acid and Parathyroid hormone have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and skin, and related phenotypes are homeostasis/metabolism and hematopoietic system

Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 512)
# Related Disease Score Top Affiliating Genes
1 osteomyelitis 32.6 TNFSF11 TNF IL6 IL1RN IL1B
2 spondyloarthropathy 1 32.6 TNFRSF1B TNF MRAP MMP3 IL17A CRP
3 synovitis 31.8 TNFSF11 TNF MMP3 MMP13 IL6 IL1RN
4 pustulosis palmaris et plantaris 31.8 TNF CD40LG CCR6
5 pustulosis of palm and sole 31.7 TNFRSF1B TNF MRAP IL1RN
6 tenosynovitis 31.7 TNFRSF1B MRAP CRP
7 bone disease 31.7 TNFSF11 TNF MMP13 IL6 IL1B ACAN
8 spondylitis 31.7 TNFRSF1B TNF IL6 IL1RN IL17A CRP
9 arthritis 31.7 TNFSF11 TNFRSF1B TNF MMP3 MMP13 IL6
10 rheumatic disease 31.6 TNF IL1B CRP CD40LG
11 pulpitis 31.6 TNF IL6 IL1B
12 typhoid fever 31.6 TNF IL6 IL1B CRP
13 meningitis 31.5 TNF IL6 IL1B CRP
14 spondyloarthropathy 31.5 TNFSF11 TNF MMP3 IL6 IL17A
15 prostatitis 31.3 TNF IL6 IL1B
16 tonsillitis 31.3 TNF IL6 IL1B
17 brucellosis 31.3 TNF IL6 IL1RN CRP CD40LG
18 end stage renal failure 31.2 TNF IL6 CRP
19 appendicitis 31.2 TNF IL6 IL1B CRP
20 histiocytosis 31.2 SERPINA3 IL1RN IL17A
21 reactive arthritis 31.2 TNF IL17A CRP
22 arthropathy 31.2 TNFSF11 TNF CRP ACAN
23 toxic shock syndrome 31.1 TNF IL6 IL1B
24 pericoronitis 31.1 TNFRSF1B IL1B CRP
25 cholangitis 31.1 TNF IL6 CRP
26 myeloma, multiple 31.0 TNFSF11 TNF IL6 CRP
27 osteoarthritis 31.0 TNF MMP3 MMP13 IL6 IL1B ADAMTS5
28 otitis media 31.0 TNF IL6 IL1B
29 exanthem 31.0 TNFRSF1B TNF IL6 IL1RN CRP
30 pneumonia 31.0 TNF IL6 IL1B CRP CD40LG
31 periodontitis, chronic 31.0 TNFSF11 IL6 IL1B
32 ileitis 31.0 TNF IL6 IL17A
33 bacterial meningitis 30.9 TNF IL6 IL1B CRP
34 psoriatic arthritis 30.9 TNFSF11 TNFRSF1B TNF MMP3 IL6 IL1B
35 colitis 30.9 TNF IL6 IL1B IL17A
36 bronchiolitis obliterans 30.9 TNF IL6 IL17A
37 bronchiolitis 30.9 TNF IL6 IL17A CRP
38 familial mediterranean fever 30.9 TNF IL1RN IL1B CRP
39 human immunodeficiency virus infectious disease 30.9 TNF IL6 CD4
40 periodontitis 30.8 TNFSF11 TNF MMP3 IL6 IL1B IL17A
41 sarcoidosis 1 30.8 TNFRSF1B TNF IL1B
42 bacterial infectious disease 30.8 TNF IL6 IL1B IL17A CRP
43 discitis 30.8 MRAP CRP
44 ulcerative colitis 30.8 TNF IL6 IL1B IL17A CRP
45 mouth disease 30.8 TNFSF11 TNF IL6 IL1B CRP
46 autoimmune disease 30.8 TNF IL6 IL1B IL17A CD40LG
47 temporal arteritis 30.7 TNF SERPINA3 IL6 IL1RN CRP
48 heart disease 30.7 TNF MMP3 IL6 IL1B CRP
49 hydrarthrosis 30.7 MMP3 MMP13 IL1RN IL1B ADAMTS5
50 osteoporosis 30.5 TNFSF11 TNF IL6 IL1RN IL1B

Graphical network of the top 20 diseases related to Bone Inflammation Disease:



Diseases related to Bone Inflammation Disease

Symptoms & Phenotypes for Bone Inflammation Disease

MGI Mouse Phenotypes related to Bone Inflammation Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 CCR6 CD4 CD40LG CRP IL17A IL1B
2 hematopoietic system MP:0005397 10.06 CCR6 CD4 CD40LG IL17A IL1B IL1RN
3 immune system MP:0005387 9.97 ADAMTS5 CCR6 CD4 CD40LG CRP IL17A
4 integument MP:0010771 9.65 ADAMTS5 CD4 CD40LG IL1B IL1RN IL6
5 skeleton MP:0005390 9.36 ADAMTS5 CD40LG IL17A IL1B IL1RN IL6

Drugs & Therapeutics for Bone Inflammation Disease

Drugs for Bone Inflammation Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 99)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zoledronic Acid Approved Phase 4 118072-93-8 68740
2
Parathyroid hormone Approved, Investigational Phase 4 9002-64-6
3
Adalimumab Approved Phase 4 331731-18-1 16219006
4
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
5
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
6
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
7 Bone Density Conservation Agents Phase 4
8 Micronutrients Phase 4
9 Trace Elements Phase 4
10 Vitamin D2 Phase 4
11 Vitamins Phase 4
12 Ergocalciferols Phase 4
13 Nutrients Phase 4
14 Calciferol Phase 4
15 Calcium, Dietary Phase 4
16 Anti-Inflammatory Agents Phase 4
17
Alendronate Approved Phase 3 66376-36-1, 121268-17-5 2088
18
Etidronic acid Approved Phase 3 2809-21-4, 7414-83-7 3305
19
Risedronate Approved, Investigational Phase 3 105462-24-6 5245
20
Abatacept Approved Phase 2, Phase 3 332348-12-6 10237
21 Antitubercular Agents Phase 3
22 Antibiotics, Antitubercular Phase 3
23 calcium channel blockers Phase 3
24 Diphosphonates Phase 3
25
Pamidronate Approved Phase 2 40391-99-9 4674
26
Amoxicillin Approved, Vet_approved Phase 1, Phase 2 26787-78-0 33613
27
Lidocaine Approved, Vet_approved Phase 1, Phase 2 137-58-6 3676
28
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
29
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
30
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
31
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
32
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
33
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
34
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
35 Anti-Infective Agents Phase 1, Phase 2
36 Anti-Bacterial Agents Phase 1, Phase 2
37 Anesthetics Phase 1, Phase 2
38 Pharmaceutical Solutions Phase 2
39 Gastrointestinal Agents Phase 2
40 Protective Agents Phase 2
41 Hormones Phase 2
42 Dexamethasone 21-phosphate Phase 2
43 Antiemetics Phase 2
44 glucocorticoids Phase 2
45 HIV Protease Inhibitors Phase 2
46
protease inhibitors Phase 2
47 Antineoplastic Agents, Hormonal Phase 2
48 Hormone Antagonists Phase 2
49 Autonomic Agents Phase 2
50 Peripheral Nervous System Agents Phase 2

Interventional clinical trials:

(show all 49)
# Name Status NCT ID Phase Drugs
1 Efficacy of DC071 Mouthwash (0.2% Chlorhexidine Digluconate) in Peri-surgical Care for Preventing Alveolar Osteitis After Third Molar Extraction Completed NCT02382809 Phase 4 DC071;Placebo
2 An Open Label, Reclast®/Aclasta®, Re-treatment of Relapsed Patients With Paget's Disease of Bone Who Participated in the CZOL446K2304 and CZOL446K2305 Core Registration Studies Completed NCT00740129 Phase 4 Zoledronic Acid
3 A 6 Months, Open-Label Phase IV Study to Confirm the Safety and Efficacy of Single Intravenous Dose of 5 mg Zoledronic Acid for the Patients of Paget's Disease of Bone (PDB) in China Completed NCT00774020 Phase 4 Zoledronic acid
4 Post US Approval Voluntary Registry Study to Determine Incidence of Hypocalcemia Post Reclast® Treatment in Patients With Paget's Disease After Institution of Educational Strategies to Improve Adherence to Calcium and Vitamin D Supplementation Completed NCT00668200 Phase 4 Reclast (ZOL446, zoledronic acid)
5 The Study of Efficacy and Safety of Calcium Sensing Receptor in Chronic Dialysis Patients Completed NCT02056730 Phase 4 calcium sensing receptor agonist
6 Can Bone Erosions Heal in Adalimumab (Humira) Treated Rheumatoid Arthritis Patients. An Imaging Study Using Computed Tomography and Magnetic Resonance Imaging. Completed NCT00696059 Phase 4 Adalimumab (Humira)
7 Open Label Study to Describe the Effect of Tocilizumab in Combination With MTX in the Evolution of Articular Damage (Synovitis/Osteitis and Erosions) Evaluated by MRI in the Hand of Patients With Moderate to Severe Rheumatoid Arthritis (RA) and Inadequate Response to Non-biological DMARDs Withdrawn NCT01878318 Phase 4 methotrexate;tocilizumab [RoActemra/Actemra]
8 A 6-Month, Multicenter, Double-Blind, Randomized, Active-Controlled Study to Evaluate the Safety, Tolerability, and Efficacy of Alendronate 280-mg Oral Buffered Solution Once Weekly in Patients With Paget's Disease of Bone Completed NCT00480662 Phase 3 alendronate
9 Randomized, Double-Blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observation Period Completed NCT00103740 Phase 3 zoledronic acid;placebo to zoledronic acid;Risedronate;Placebo to risedronate;Calcium and vitamin D supplements
10 Randomized, Double-blind, Safety and Efficacy Trial With Intravenous Zoledronic Acid for the Treatment of Paget's Disease of Bone Using Risedronate as a Comparator, Including an Extended Observational Period Completed NCT00051636 Phase 3 Zoledronic Acid;Risedronate;Placebo to Risedronate;Placebo to Zoledronic Acid
11 Antibiotic Efficacy in Third Molar Surgery Completed NCT00118820 Phase 3 IV Preoperative antibiotic or placebo
12 An Open-Label, Pilot Trial to Assess the Impact of Subcutaneous Abatacept in Rheumatoid Arthritis Assessing Inhibition of Structural Damage Determined by Low Field Extremity MRI (eMRI) and X-ray Completed NCT01333878 Phase 2, Phase 3
13 Chronic Non-bacterial Osteomyelitis Treated With Pamidronate in a Randomised Placebo Controlled Trial Unknown status NCT02594878 Phase 2 Pamidronatdinatrium
14 The Influence of Intra-alveolar Application of Honey on Healing Following Molar Teeth Extraction: A Randomized Clinical Trial Unknown status NCT02678104 Phase 2 Chlorhexidine mouth wash;Intra-alveolar application of Manuka Honey
15 Does a Single Dose of Systemic Antibiotics Prevent Postoperative Inflammatory Complications After Lower Third Molar Surgery? A Randomized Controlled Trial Completed NCT03130933 Phase 1, Phase 2 Amoxicillin 500 Mg
16 Iontophoresis With Dexamethasone in Combination With Physical Therapy for the Treatment of Pediatric Patients Diagnosed With Apophysitis of the Knee: A Randomized, Double-Blind, Placebo-Controlled Trial Recruiting NCT03606980 Phase 2 Dexamethasone Sodium Phosphate
17 MRI Evaluation Assessing Synovitis to Address the Unmet Need for Reliable Endpoints in SLE Recruiting NCT03355482 Phase 2 Methylprednisolone;Placebos
18 A Phase IIB, Multi-Centre, Randomised, Double-Blind, Placebo-Controlled, Parallel Group Study of the Efficacy and Safety of Fostamatinib Disodium Monotherapy Compared With Placebo or Adalimumab Monotherapy in Patients With Active Rheumatoid Arthritis: Magnetic Resonance Imaging Sub-Study Terminated NCT02092961 Phase 2 Fostamatinib;Adalimumab;Placebo of Fostamatinib;Placebo of Adalimumab
19 A Human Pilot Study to Quantify BCG From the BCG Vaccination Site, and to More Fully Characterise the Immune Response to BCG Completed NCT00653627 Phase 1
20 Preliminary Study for Identification of Calcium-Binding Proteins in the Serum in Various Metabolic Bone Disorders Unknown status NCT00403598
21 Allogenic Vascularized Knee and Femur Transplantation Clinical Evaluation Unknown status NCT01133145
22 Comparison of Three Treatments for Lower Extremity Apophysitis Unknown status NCT01826071
23 The Association of Serum Sclerostin Levels,Echocardiographic Parameters, Arteriovenous Fistula Thrombosis and Carpal Tunnel Syndrome in Maintenance Hemodialysis Patients Unknown status NCT01382966
24 To Evaluate the Efficacy of Aloe Vera Gel in Gingival Massaging and as an Adjunct to Scaling and Root Planing in Patients With Chronic Periodontitis Unknown status NCT03083535
25 Total ExtraPeritoneal (TEP) Versus Open Minimal Suture Repair for Treatment of Sportsman's Hernia/Athletic Pubalgia: A Randomized Multi-center Trial. Unknown status NCT02297711
26 A Tetracycline Drain Reduces Alveolar Osteitis in Third Molar Surgery Completed NCT03494972 Tetracyclin ointment
27 Effectiveness of Custom-made Foot Orthoses vs Heel Lifts in Children With Calcaneal Apophysitis (Sever Disease): a Randomized Controlled Trial Completed NCT03960086
28 Effect of NBF Gingival Gel Application in Controlling Post-surgical Complications After Impacted Lower Third Molar Surgery Completed NCT03641482 NBF
29 Chronic Groin Pain and Sportsman Hernia of Athletes: Randomized Study Between Conservative Treatment and Laparoscopic Hernioplasty (TEP) Completed NCT00966589
30 Management of Septic Non-union of the Tibia Using the "Induced Membrane" Technique Completed NCT03940638
31 Sodium Risedronate 17.5 mg Tablets Special Drug Use Surveillance in Patients With Osseous Paget's Disease (All-case Surveillance) - 48-week Surveillance − Completed NCT02106455 Sodium risedronate
32 Schnitzler Syndrome: Clinical Study, Physiopathological and Search for Genetic Completed NCT00933296
33 Evaluation of Quality of Life in Patients Undergoing Parathyroidectomy Completed NCT00905866
34 A Study of Maintenance Therapy After Intravenous Maxacalcitol for Secondary Hyperparathyroidism Completed NCT00828347 1.0 μg/day Alfacalcidol;0.25 μg/day Alfacalcidol
35 Does an MRI-guided Treatment Strategy Reduce Disease Activity and Progression in Patients With Rheumatoid Arthritis (RA): a Randomised Controlled Trial Completed NCT01656278
36 Acutely Infected Teeth: To Extract Or Not To Extract? Completed NCT03485664
37 Clinical Outcome of Dental Extractions Among Renal Transplant Recipients Completed NCT02547753
38 Three-dimensional Measurements for Monitoring Wound Healing of Diabetic Foot Ulcers Completed NCT02423850
39 Use of 18F-Fluoride Positron Emission Tomography in the Assessment and Evaluation of Therapy in Monostotic Paget's Disease of Bone Completed NCT00306046 Bisphosphonate treatment
40 Genetic Study of Families Affected by Paget's Disease of Bone Completed NCT00747994
41 Evaluation Of Antiplaque Efficacy Of Licorice Extract Mouthrinse & Hypertonic Salt Solution And Their Comparison With Essential Oil & Chlorhexidine Mouthrinses-An Invitro & Invivo Study" Completed NCT03550651
42 The Influence of Concentrated Growth Factors (CGF) Application on Post-operative Complications. Recruiting NCT03992573
43 Characterization of Familial Myopathy and Paget Disease of Bone Recruiting NCT01353430
44 Groin Injuries in Finnish Contact Sports: Prospective 2-year Clinical and Magnetic Resonance Imaging Study Recruiting NCT02560480
45 Circulating microRNA Signatures in Primary Hyperparathyroidism Recruiting NCT03931109
46 Investigation of Pathophysiology of Angiogenesis and Osteogenesis in Paget's Disease of Bone Recruiting NCT02802384
47 Influence of Leukocyte- and Platelet Rich Fibrin (L-PRF) on the Outcomes of Impacted Mandibular Third Molar Removal Surgery: a Split-mouth Randomized Clinical Trial Active, not recruiting NCT03357484
48 Pressure Sore-related Osteitis Treated by Flap Coverage and Short Antibiotic Regimen Enrolling by invitation NCT03964818
49 A Comparison of Single Preoperative Dose of Co-amoxiclav Versus Postoperative Full Course of Amoxicillin/ Co-amoxiclav in Prevention of Postoperative Complications in Dentoalveolar Surgery: a Randomized Controlled Trial Not yet recruiting NCT03844776 Co-Amoxiclav;Paracetamol;Chlorhexidine mouthwash;Normal saline;Amoxicillin 500 Mg;Metronidazole

Search NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

Genetic Tests for Bone Inflammation Disease

Anatomical Context for Bone Inflammation Disease

MalaCards organs/tissues related to Bone Inflammation Disease:

41
Bone, Prostate, Skin, Bone Marrow, Kidney, Neutrophil, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Inflammation Disease:

19
Bone

Publications for Bone Inflammation Disease

Articles related to Bone Inflammation Disease:

(show top 50) (show all 4320)
# Title Authors PMID Year
1
What constitutes the fat signal detected by MRI in the spine of patients with ankylosing spondylitis? A prospective study based on biopsies obtained during planned spinal osteotomy to correct hyperkyphosis or spinal stenosis. 38
31122911 2019
2
Determining MRI Inflammation Targets When Considering a Rheumatoid Arthritis Treat-to-Target Strategy: Results of a Randomized, Placebo-Controlled Trial. 38
31278695 2019
3
The usefulness of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) sequences visual assessment in the early diagnosis of axial spondyloarthritis. 38
31292710 2019
4
The influence of flap design on sequelae and quality of life following surgical removal of impacted mandibular third molars: A split-mouth randomised clinical trial. 38
31050816 2019
5
SAPHO syndrome of the temporomandibular joint associated with trismus: a case report and review of the literature. 38
31414280 2019
6
MRI and Dose Selection in a Phase II Trial of Baricitinib with Conventional Synthetic Disease-modifying Antirheumatic Drugs in Rheumatoid Arthritis. 38
30647190 2019
7
Frontal sinus ablation (Riedel-Mosher’s procedure): indications and role in the endonasal endoscopic era. 38
30984921 2019
8
Establishment and verification of a mouse model of nasal wound healing. 38
30675728 2019
9
Long-term remarkable remission of SAPHO syndrome in response to short-term systemic corticosteroids treatment in an immunoglobulin E elevated patient: A case report. 38
31277098 2019
10
Chronic non-bacterial osteomyelitis: a comparative study between children and adults. 38
31337412 2019
11
SAPHO Syndrome in an Adult Male with Ulcerative Colitis. 38
31253222 2019
12
SAPHO: has the time come for tailored therapy? 38
31312988 2019
13
Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study. 38
30767869 2019
14
Images of the month 3: The 'bull's head' sign of SAPHO syndrome. 38
31308121 2019
15
The very early inflammatory triquetral lesion by MRI - is this the first sign in Rheumatoid Arthritis? 38
31300634 2019
16
Staged arthrodesis using the Masquelet technique for osteomyelitis of the finger with articular destruction: a report of two cases. 38
31093754 2019
17
Efficacy of pamidronate in children with chronic non-bacterial osteitis using whole body MRI as a marker of disease activity. 38
31272461 2019
18
Impact of platelet-rich fibrin on mandibular third molar surgery recovery: a systematic review and meta-analysis. 38
31345203 2019
19
Preclinical assessment of the potential of a 3D chitosan drug delivery system with sodium meloxicam for treating complications following tooth extraction. 38
30986462 2019
20
Alveolar Iodine Tampon Packing Reduces Postoperative Morbidity After Third Molar Surgery. 38
31344339 2019
21
MR and ultrasound of the hands and wrists in rheumatoid arthritis. Part II. Added clinical value. 38
30806723 2019
22
Emergence of severe spondyloarthropathy-related entheseal pathology following successful vedolizumab therapy for inflammatory bowel disease. 38
30204909 2019
23
Genotype-phenotype correlation and expansion of orodental anomalies in LTBP3-related disorders. 38
30887145 2019
24
MRI Results Following Discontinuation of Methotrexate in Patients With Rheumatoid Arthritis Treated With Subcutaneous Tocilizumab: The COMP-ACT MRI Substudy. 38
31154414 2019
25
Value of dedicated small-field-of-view sacroiliac versus large-field-of-view pelvic magnetic resonance imaging for evaluating pediatric sacroiliitis. 38
30623211 2019
26
Successful treatment and digestive decolonisation of a patient with osteitis caused by a carbapenemase-producing Klebsiella pneumoniae isolate harbouring both NDM-1 and OXA-48 enzymes. 38
31201994 2019
27
Is implant placement performed at the same surgical time as orbital exenteration a viable procedure? 38
31184634 2019
28
Revisiting the Clinical Scoring System for the Prognosis of Chronic Rhinosinusitis with Nasal Polyps. 38
31124342 2019
29
Adjunctive Use of Plasma Rich in Growth Factors for Improving Alveolar Socket Healing: A Systematic Review. 38
31326048 2019
30
Serum levels of proinflammatory, anti-inflammatory cytokines, and RANKL/OPG in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome. 38
29694253 2019
31
MRI and ultrasound of the hands and wrists in rheumatoid arthritis. I. Imaging findings. 38
30796506 2019
32
Chondrosarcoma as inaugural manifestation of monostotic Paget's disease of Bone. 38
31266050 2019
33
Radiographic Prevalence of Symphysis Pubis Abnormalities and Clinical Outcomes in Patients With Femoroacetabular Impingement Syndrome. 38
30995415 2019
34
Musculoskeletal ultrasound versus MRI of the hands in healthy subjects - a pilot study. 38
31063513 2019
35
Characteristics of Chronic Maxillary Sinusitis in Patients With a History of Long-term Bisphosphonate Use. 38
31041868 2019
36
Syphilis with Charcot arthropathy: A case report. 38
30758895 2019
37
Progression of Structural Damage in the Sacroiliac Joints in Patients With Early Axial Spondyloarthritis During Long-Term Anti-Tumor Necrosis Factor Treatment: Six-Year Results of Continuous Treatment With Etanercept. 38
30625261 2019
38
Bone turnover markers predict type of bone histomorphometry and bone mineral density in Asian chronic haemodialysis patients. 38
30980579 2019
39
Serum IgG4 elevation in SAPHO syndrome: does it unmask a disease activity marker? 38
31025928 2019
40
Pathology in the appendicular bones of southern tamandua, Tamandua tetradactyla (Xenarthra, Pilosa): injuries to the locomotor system and first case report of osteomyelitis in anteaters. 38
31023313 2019
41
Clinical Manifestations, Management, and Outcomes of Osteitis/Osteomyelitis Caused by Mycobacterium bovis Bacillus Calmette-Guérin in Children: Comparison by Site(s) of Affected Bones. 38
30577978 2019
42
Is treatment with platelet-rich fibrin better than zinc oxide eugenol in cases of established dry socket for controlling pain, reducing inflammation, and improving wound healing? 38
31106135 2019
43
A metagenomic study of patients with alveolar osteitis after tooth extraction. A preliminary case-control study. 38
30937543 2019
44
Non-invasive fungal sinusitis resulting in multiple cranial nerve neuropathies. 38
30967452 2019
45
Detection of Sacroiliitis by Short-tau Inversion Recovery and T2-weighted Turbo Spin Echo Sequences: Results from the SIMACT Study. 38
30647167 2019
46
Bone scintigraphy analysis of 44 cases of pustulotic arthro-osteitis associated with palmoplantar pustulosis. 38
30230567 2019
47
Osteitis Condensans Ilii: An Uncommon Cause of Back Pain. 38
31259127 2019
48
MRI of the Sacroiliac Joint in Healthy Children. 38
30973768 2019
49
Magnetic resonance imaging of the sacroiliac joints in SpA: with or without intravenous contrast media? A preliminary report. 38
30868439 2019
50
Oral care of a patient with a SAPHO syndrome and a nickel allergy. 38
30761569 2019

Variations for Bone Inflammation Disease

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show top 50) (show all 52)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 TNFSF11 TNFRSF1B TNF SERPINA3 MMP3 IL6
2
Show member pathways
13.87 TNFSF11 TNFRSF1B TNF IL6 IL1B IL17A
3
Show member pathways
13.69 TNFSF11 TNFRSF1B TNF IL6 IL1RN IL1B
4
Show member pathways
13.42 TNFSF11 TNFRSF1B TNF IL6 IL1B IL17A
5
Show member pathways
13.32 TNFSF11 TNFRSF1B TNF IL6 IL1B IL17A
6
Show member pathways
13.3 TNFSF11 TNFRSF1B TNF MMP3 IL6 IL1RN
7
Show member pathways
12.85 TNFRSF1B TNF IL6 IL1B IL17A ICOSLG
8
Show member pathways
12.71 TNFRSF1B TNF IL6 IL1B CD40LG
9
Show member pathways
12.69 TNFRSF1B TNF IL1B CD40LG CD4
10
Show member pathways
12.64 TNFRSF1B TNF ICOSLG CD40LG CD4
11
Show member pathways
12.63 TNFSF11 TNFRSF1B TNF IL1B CD40LG
12
Show member pathways
12.6 TNF IL6 IL1B IL17A CD4
13
Show member pathways
12.6 TNF IL6 IL1B IL17A CD4
14
Show member pathways
12.58 TNF IL6 IL1B IL17A CD40LG CD4
15 12.46 TNFSF11 TNFRSF1B TNF IL1RN IL1B IL17A
16
Show member pathways
12.37 TNF SERPINA3 IL6 IL1B CRP
17
Show member pathways
12.35 TNF MMP3 MMP13 IL6 IL1B IL17A
18 12.26 TNFSF11 TNFRSF1B TNF CD40LG
19
Show member pathways
12.23 TNF IL6 IL1RN IL1B
20
Show member pathways
12.21 MMP3 MMP13 IL1B CCR6 ACAN
21 12.18 TNF IL6 IL1RN IL1B
22
Show member pathways
12.09 TNFRSF1B IL6 IL1B IL17A CD4
23
Show member pathways
12.09 TNF IL6 IL1B IL17A CD4
24 12.03 TNF IL6 IL1B ACAN
25 11.99 TNFRSF1B TNF MMP3 IL6 IL1B
26 11.95 TNFSF11 TNF IL1B CD40LG
27 11.93 TNF IL6 IL1B CD4
28
Show member pathways
11.9 TNF MMP3 IL6 IL1B ADAMTS5 ACAN
29 11.89 TNF IL6 IL1B
30
Show member pathways
11.82 TNFSF11 IL6 CRP
31 11.79 TNF IL6 IL1B CD4
32
Show member pathways
11.78 TNFSF11 TNFRSF1B TNF CD40LG
33 11.76 TNF IL6 IL1B
34 11.73 TNF IL1B IL17A CD4 CCR6
35 11.69 MMP13 ADAMTS5 ACAN
36 11.69 TNFRSF1B TNF MMP3 IL6 IL1B IL17A
37 11.67 TNF IL6 IL1B
38 11.61 TNF IL6 IL1B
39 11.58 TNF IL6 IL1B CD40LG
40
Show member pathways
11.57 TNF MMP3 IL6 IL1B CD40LG
41 11.52 TNFSF11 TNF IL6 IL1B
42 11.4 TNF IL6 IL1B
43 11.4 TNFSF11 TNF MMP3 IL6 IL1B IL17A
44 11.38 TNF IL6 IL1B
45 11.34 TNFRSF1B TNF IL6 IL1RN IL1B
46 11.33 TNF IL6 IL1B IL17A
47 11.32 TNF IL6 IL1B
48 11.24 TNF IL6 IL1B CD4
49 11.16 TNFSF11 TNF IL6 IL1B IL17A CD40LG
50 11.08 TNF IL6 CRP

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 TNFSF11 TNFRSF1B TNF SERPINA3 MMP3 MMP13
2 external side of plasma membrane GO:0009897 9.63 TNF IL17A ICOSLG CD40LG CD4 CCR6
3 extracellular space GO:0005615 9.44 TNFSF11 TNF SERPINA3 MMP3 MMP13 MIR140

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.89 TNFSF11 TNF IL6 IL1B
2 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.89 TNFSF11 TNF IL1RN IL1B CD4
3 cellular response to lipopolysaccharide GO:0071222 9.88 TNFRSF1B TNF IL6 IL1RN IL1B
4 positive regulation of JNK cascade GO:0046330 9.86 TNFSF11 TNF IL1RN IL1B
5 defense response to Gram-positive bacterium GO:0050830 9.84 TNF IL6 CRP
6 extracellular matrix disassembly GO:0022617 9.83 MMP3 MMP13 ADAMTS5
7 tumor necrosis factor-mediated signaling pathway GO:0033209 9.83 TNFSF11 TNFRSF1B TNF CD40LG
8 humoral immune response GO:0006959 9.82 TNF IL6 CCR6
9 inflammatory response GO:0006954 9.81 TNFRSF1B TNF SERPINA3 IL6 IL1RN IL1B
10 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.8 TNFSF11 TNF IL6 IL1B CD40LG
11 acute-phase response GO:0006953 9.78 SERPINA3 IL6 CRP
12 negative regulation of neurogenesis GO:0050768 9.76 TNF IL6 IL1B
13 positive regulation of T cell proliferation GO:0042102 9.76 IL6 IL1B CD40LG CD4
14 positive regulation of osteoclast differentiation GO:0045672 9.74 TNFSF11 TNF IL17A
15 positive regulation of interleukin-6 production GO:0032755 9.73 TNF IL6 IL1RN IL1B
16 positive regulation of glial cell proliferation GO:0060252 9.72 TNF IL6 IL1B
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.71 TNFRSF1B TNF IL1B
18 response to glucocorticoid GO:0051384 9.69 TNF IL6 IL1RN
19 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.66 IL1B CD4
20 positive regulation of chemokine biosynthetic process GO:0045080 9.65 TNF IL1B
21 regulation of establishment of endothelial barrier GO:1903140 9.65 TNF IL1B
22 immune response GO:0006955 9.65 TNFSF11 TNFRSF1B TNF IL6 IL1RN IL1B
23 tooth eruption GO:0044691 9.64 TNFSF11 ADAMTS5
24 regulation of immunoglobulin secretion GO:0051023 9.63 TNF CD40LG
25 positive regulation of fever generation GO:0031622 9.63 TNF IL1B
26 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.62 IL6 IL1RN
27 sequestering of triglyceride GO:0030730 9.62 TNF IL1B
28 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.6 TNF IL1B
29 negative regulation of lipid storage GO:0010888 9.54 TNF IL6 CRP
30 positive regulation of neuroinflammatory response GO:0150078 9.5 TNF IL6 IL1B
31 positive regulation of JUN kinase activity GO:0043507 9.31 TNF
32 cytokine-mediated signaling pathway GO:0019221 9.28 TNFSF11 TNFRSF1B TNF MMP3 IL6 IL1RN
33 chronic inflammatory response to antigenic stimulus GO:0002439 8.96 TNF
34 positive regulation of gene expression GO:0010628 10.05 TNFSF11 TNF MIR140 IL6 IL1B CRP

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 9.26 IL1RN IL1B
2 cytokine activity GO:0005125 9.17 TNFSF11 TNF IL6 IL1RN IL1B IL17A
3 tumor necrosis factor receptor binding GO:0005164 9.13 TNFSF11 TNF CD40LG
4 protein binding GO:0005515 10.09 TNFSF11 TNFRSF1B TNF SERPINA3 MRAP MMP3

Sources for Bone Inflammation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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49 NCI
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51 NDF-RT
54 NINDS
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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