MCID: BNN003
MIFTS: 37

Bone Inflammation Disease

Categories: Bone diseases

Aliases & Classifications for Bone Inflammation Disease

MalaCards integrated aliases for Bone Inflammation Disease:

Name: Bone Inflammation Disease 12 15
Osteitis 12 44 73
Inflammatory Disorder of Bone 12
Bone Inflammatory Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3342
MeSH 44 D010000
UMLS 73 C0029400

Summaries for Bone Inflammation Disease

Disease Ontology : 12 A bone disease that results in inflammation of the located in bone.

MalaCards based summary : Bone Inflammation Disease, also known as osteitis, is related to osteomyelitis and arthropathy. An important gene associated with Bone Inflammation Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. Affiliated tissues include bone and bone, and related phenotypes are homeostasis/metabolism and cellular

Related Diseases for Bone Inflammation Disease

Diseases related to Bone Inflammation Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 293)
# Related Disease Score Top Affiliating Genes
1 osteomyelitis 32.4 IL1B IL1RN IL6 TNF TNFSF11
2 arthropathy 32.4 ACAN COMP CRP TNF TNFSF11
3 spondyloarthropathy 1 32.1 CD40LG CRP IL17A MMP3 MRAP TNF
4 synovitis 31.3 COMP CRP IL1B IL1RN IL6 MMP13
5 arthritis 30.9 ACAN ADAMTS5 HLA-DRB1 IL17A IL1B IL1RN
6 osteitis fibrosa 12.4
7 condensing osteitis of the clavicle 12.2
8 paget's disease of bone 12.0
9 aseptic osteitis 12.0
10 sapho syndrome 11.8
11 paget disease of bone 3 11.4
12 scleral disease 11.3 MRAP TNF TNFRSF1B
13 pustulosis of palm and sole 11.3 MRAP TNF TNFRSF1B
14 tenosynovitis 11.2 CRP MRAP TNFRSF1B
15 dental pulp disease 11.2 IL1B TNF TRPV1
16 burning mouth syndrome 11.2 IL6 TNF TRPV1
17 renal osteodystrophy 11.2
18 laryngitis 11.2 IL1B IL6 TNF
19 scorpion envenomation 11.2 IL6 TNF
20 iritis 11.2 CD40LG MRAP TNFRSF1B
21 pericoronitis 11.2 CRP IL1B TNFRSF1B
22 spinal disease 11.2 CRP IL6 MRAP
23 acute vascular insufficiency of intestine 11.2 IL1B IL6 TNF
24 poems syndrome 11.2 IL1B IL6 TNF
25 posterior scleritis 11.2 MRAP TNF TNFRSF10A
26 uremic pruritus 11.2 CRP IL1B IL6
27 stachybotrys chartarum 11.2 IL1B IL6 TNF
28 mammary paget's disease 11.2
29 louse-borne relapsing fever 11.2 CRP IL6 TNF
30 periodontitis, chronic 11.2 IL1B IL6 TNFSF11
31 rosacea 11.2 IL6 TNF TRPV1
32 ischemic heart disease 11.2 CRP IL6 TNF
33 eales disease 11.2 IL1B IL6 TNF
34 diverticulitis 11.2 CRP MMP13 TNF
35 mesenteric lymphadenitis 11.2 CRP IL6 MRAP
36 suppurative otitis media 11.2 CD40LG CRP IL1B
37 anca-associated vasculitis 11.2 HLA-DRB1 IL6 TNF
38 ocular toxoplasmosis 11.2 CD40LG IL17A TLR9
39 vulvar vestibulitis syndrome 11.2 IL1B IL1RN TNF
40 actinic prurigo 11.2 HLA-DRB1 IL1B TNF
41 endometritis 11.2 IL1B IL6 TNF
42 jejunoileitis 11.2 CD40LG IL1B TNF
43 nose disease 11.2 TLR9 TNF TRPV1
44 pleural disease 11.2 CRP IL1B TNF
45 lichen disease 11.2 CD40LG TLR9 TNF
46 pyuria 11.2 BCKDHA CRP MRAP
47 systolic heart failure 11.2 CRP IL6 TNF
48 cerebral artery occlusion 11.2 IL1B IL1RN TNF
49 microscopic colitis 11.2 HLA-DRB1 IL6 TNF
50 transverse myelitis 11.2 IL17A IL6 TNF

Graphical network of the top 20 diseases related to Bone Inflammation Disease:



Diseases related to Bone Inflammation Disease

Symptoms & Phenotypes for Bone Inflammation Disease

MGI Mouse Phenotypes related to Bone Inflammation Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 TNF TNFRSF10A TNFRSF1B TNFSF11 TRPV1 IL17A
2 cellular MP:0005384 10.14 TRPV1 TNF TNFRSF10A TNFRSF1B TLR9 MMP13
3 cardiovascular system MP:0005385 10.13 TRPV1 TNF TNFRSF1B CRP MMP13 IL1B
4 immune system MP:0005387 10.13 TNFRSF10A TNFRSF1B TNFSF11 TRPV1 TNF IL17A
5 hematopoietic system MP:0005397 10.11 TNF TNFRSF10A TNFRSF1B TNFSF11 TLR9 IL17A
6 integument MP:0010771 9.85 TNF TNFRSF1B TNFSF11 TRPV1 MMP13 IL1B
7 neoplasm MP:0002006 9.5 TNF TNFRSF10A TNFRSF1B TNFSF11 TRPV1 IL1B
8 skeleton MP:0005390 9.4 TNFRSF1B TNFSF11 TNF IL17A MMP3 IL1B

Drugs & Therapeutics for Bone Inflammation Disease

Search Clinical Trials , NIH Clinical Center for Bone Inflammation Disease

Cochrane evidence based reviews: osteitis

Genetic Tests for Bone Inflammation Disease

Anatomical Context for Bone Inflammation Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Inflammation Disease:

19
Bone

MalaCards organs/tissues related to Bone Inflammation Disease:

41
Bone

Publications for Bone Inflammation Disease

Variations for Bone Inflammation Disease

Expression for Bone Inflammation Disease

Search GEO for disease gene expression data for Bone Inflammation Disease.

Pathways for Bone Inflammation Disease

Pathways related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.03 CD40LG CRP HLA-DRB1 IL17A IL1B IL1RN
2
Show member pathways
13.68 CD40LG IL17A IL1B IL1RN IL6 TNF
3
Show member pathways
13.4 CD40LG IL17A IL1B IL6 TLR9 TNF
4
Show member pathways
13.3 CD40LG IL17A IL1B IL6 TNF TNFRSF10A
5
Show member pathways
13.3 CD40LG HLA-DRB1 IL17A IL1B IL1RN IL6
6
Show member pathways
12.88 CD40LG HLA-DRB1 IL17A IL1B IL6 TNF
7
Show member pathways
12.8 HLA-DRB1 IL1B IL6 TLR9 TNF TNFRSF10A
8
Show member pathways
12.74 ACAN ADAMTS5 COMP MMP13 MMP3
9
Show member pathways
12.71 CD40LG IL1B IL6 TLR9 TNF TNFRSF1B
10
Show member pathways
12.46 HLA-DRB1 IL17A IL1B IL6 TNF
11
Show member pathways
12.43 CD40LG IL17A IL1B IL6 TNF
12
Show member pathways
12.41 CD40LG IL1B TLR9 TNF TNFRSF1B TNFSF11
13
Show member pathways
12.33 CRP IL1B IL6 TNF
14
Show member pathways
12.29 IL17A IL1B IL6 MMP13 MMP3 TNF
15 12.27 CD40LG IL17A IL1B IL1RN TLR9 TNF
16
Show member pathways
12.25 CD40LG HLA-DRB1 IL1B TNF
17
Show member pathways
12.24 IL17A IL1B IL6 TLR9 TNF
18
Show member pathways
12.22 IL1B IL1RN IL6 TNF
19 12.22 CD40LG TNF TNFRSF10A TNFRSF1B TNFSF11
20
Show member pathways
12.21 IL1B IL6 TLR9 TNF
21 12.2 HLA-DRB1 IL1B IL6 TLR9 TNF
22
Show member pathways
12.18 IL1B IL6 TLR9 TNF
23 12.18 IL1B IL1RN IL6 TNF
24
Show member pathways
12.08 IL17A IL1B IL6 TNFRSF10A TNFRSF1B
25 12.03 ACAN IL1B IL6 TNF
26 11.96 IL1B IL6 MMP3 TNF TNFRSF1B
27 11.91 HLA-DRB1 IL1B IL6 TNF
28 11.9 CD40LG IL1B TNF TNFSF11
29
Show member pathways
11.81 CRP IL6 TNFSF11
30 11.79 IL17A IL1B IL6 MMP3 TNF TNFRSF1B
31 11.78 IL17A IL1B TNF
32 11.75 IL1B IL6 TNF
33 11.75 IL1B IL6 TLR9 TNF
34
Show member pathways
11.74 CD40LG TNF TNFRSF1B TNFSF11
35 11.68 ACAN ADAMTS5 MMP13
36 11.66 IL1B IL6 TNF
37 11.6 IL1B IL6 TNF
38
Show member pathways
11.57 CD40LG IL1B IL6 MMP3 TNF
39 11.49 IL1B IL6 TNF TNFSF11
40 11.41 IL1B IL1RN IL6 TNF TNFRSF1B
41 11.37 IL1B IL6 TNF
42 11.36 IL1B IL6 TLR9 TNF
43 11.31 IL1B IL6 TNF
44 11.26 IL17A IL1B IL6 TNF
45 11.21 HLA-DRB1 IL1B IL6 TNF
46 11.12 CD40LG COMP IL1B IL6 TLR9 TNF
47 11.12 HLA-DRB1 IL17A IL1B IL6 MMP3 TNF
48 11.05 CRP IL6 TNF

GO Terms for Bone Inflammation Disease

Cellular components related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 ADAMTS5 CD40LG COMP CRP IL17A IL1B
2 extracellular matrix GO:0031012 9.56 ACAN COMP MMP13 MMP3
3 external side of plasma membrane GO:0009897 9.55 CD40LG HLA-DRB1 IL17A TNF TRPV1
4 extracellular region GO:0005576 9.5 ACAN ADAMTS5 CD40LG COMP CRP IL17A

Biological processes related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.93 IL1B TLR9 TNF TNFSF11
2 positive regulation of MAPK cascade GO:0043410 9.91 IL6 TLR9 TNFRSF10A TNFRSF1B
3 regulation of signaling receptor activity GO:0010469 9.91 CD40LG IL17A IL1B IL1RN IL6 TNF
4 positive regulation of DNA binding transcription factor activity GO:0051091 9.86 IL1B IL6 TNF TNFSF11
5 apoptotic signaling pathway GO:0097190 9.84 TNF TNFRSF10A TNFRSF1B
6 response to glucocorticoid GO:0051384 9.83 IL1RN IL6 TNF
7 positive regulation of T cell proliferation GO:0042102 9.83 CD40LG IL1B IL6
8 extracellular matrix disassembly GO:0022617 9.81 ACAN ADAMTS5 MMP13 MMP3
9 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.8 IL1B TLR9 TNF
10 positive regulation of JNK cascade GO:0046330 9.8 IL1B TLR9 TNF TNFSF11
11 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 CD40LG TNF TNFRSF10A TNFRSF1B TNFSF11
12 extrinsic apoptotic signaling pathway GO:0097191 9.77 TNF TNFRSF10A TNFRSF1B
13 positive regulation of nitric oxide biosynthetic process GO:0045429 9.77 IL1B TNF TRPV1
14 positive regulation of interleukin-6 production GO:0032755 9.76 IL1B IL6 TLR9 TNF
15 cytokine-mediated signaling pathway GO:0019221 9.76 IL17A IL1B IL1RN IL6 MMP3 TNF
16 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.73 CD40LG IL1B IL6 TLR9 TNF TNFSF11
17 positive regulation of interleukin-8 production GO:0032757 9.72 IL1B TLR9 TNF
18 positive regulation of osteoclast differentiation GO:0045672 9.71 IL17A TNF TNFSF11
19 positive regulation of chemokine production GO:0032722 9.7 IL6 TLR9 TNF
20 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.67 IL1B TNF
21 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.66 IL1B TLR9
22 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
23 growth plate cartilage development GO:0003417 9.65 COMP MMP13
24 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.65 IL1B TNF TNFRSF1B
25 immune response GO:0006955 9.65 CD40LG HLA-DRB1 IL17A IL1B IL1RN IL6
26 regulation of establishment of endothelial barrier GO:1903140 9.64 IL1B TNF
27 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
28 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.62 IL1RN IL6
29 regulation of immunoglobulin secretion GO:0051023 9.61 CD40LG TNF
30 negative regulation of lipid storage GO:0010888 9.61 CRP IL6 TNF
31 tooth eruption GO:0044691 9.58 ADAMTS5 TNFSF11
32 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.57 IL1B TNF
34 fever generation GO:0001660 9.5 IL1B IL1RN TRPV1
35 inflammatory response GO:0006954 9.36 CD40LG CRP IL17A IL1B IL1RN IL6
36 positive regulation of gene expression GO:0010628 10.04 CRP IL1B IL6 TLR9 TNF

Molecular functions related to Bone Inflammation Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 9.43 CD40LG TNF TNFSF11
2 cytokine activity GO:0005125 9.17 CD40LG IL17A IL1B IL1RN IL6 TNF
3 interleukin-1 receptor binding GO:0005149 9.13 IL1B IL1RN TLR9
4 protein binding GO:0005515 10.13 ACAN ADAMTS5 BCKDHA CD40LG COMP CRP

Sources for Bone Inflammation Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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