MCID: BNL001
MIFTS: 19

Bone Leiomyosarcoma

Categories: Bone diseases, Cancer diseases, Muscle diseases

Aliases & Classifications for Bone Leiomyosarcoma

MalaCards integrated aliases for Bone Leiomyosarcoma:

Name: Bone Leiomyosarcoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3367
NCIt 49 C7154
UMLS 71 C1332579

Summaries for Bone Leiomyosarcoma

MalaCards based summary : Bone Leiomyosarcoma is related to leiomyosarcoma and fibrosarcoma, and has symptoms including pain An important gene associated with Bone Leiomyosarcoma is HEATR4 (HEAT Repeat Containing 4), and among its related pathways/superpathways is mRNA Editing- C to U Conversion. Affiliated tissues include bone.

Related Diseases for Bone Leiomyosarcoma

Diseases related to Bone Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 leiomyosarcoma 10.4
2 fibrosarcoma 9.8
3 soft tissue sarcoma 9.8
4 rare tumor 9.8
5 human t-cell leukemia virus type 1 9.6 APOBEC3B APOBEC3A
6 recessive dystrophic epidermolysis bullosa 9.4 APOBEC3B APOBEC3A

Graphical network of the top 20 diseases related to Bone Leiomyosarcoma:



Diseases related to Bone Leiomyosarcoma

Symptoms & Phenotypes for Bone Leiomyosarcoma

UMLS symptoms related to Bone Leiomyosarcoma:


pain

Drugs & Therapeutics for Bone Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Bone Leiomyosarcoma

Genetic Tests for Bone Leiomyosarcoma

Anatomical Context for Bone Leiomyosarcoma

MalaCards organs/tissues related to Bone Leiomyosarcoma:

40
Bone

Publications for Bone Leiomyosarcoma

Articles related to Bone Leiomyosarcoma:

(show all 13)
# Title Authors PMID Year
1
Primary Leiomyosarcoma of Bone: Review and Update. 61
31661313 2019
2
Denosumab as a potential therapeutic option for leiomyosarcoma with osteoclast-like giant cells: A case report. 61
29387393 2018
3
Choroidal metastasis from primary bone leiomyosarcoma. 61
26109142 2015
4
Including MIR of a primary bone leiomyosarcoma that radiologically mimics a giant cell tumor. 61
18389991 2008
5
Lower gastrointestinal bleeding due to small bowel metastasis from leiomyosarcoma in the tibia. 61
17051843 2006
6
Subperiosteal leiomyosarcoma of the tibia. 61
15635482 2005
7
[Leiomyosarcoma of the bone.]. 61
20478187 2000
8
[Primary bone leiomyosarcoma. Anatomo-clinical, immunohistochemical, and ultrastructural study]. 61
10637889 1999
9
[Primary bone leiomyosarcoma. Anatomo-clinical case with immunohistochemistry study and review of the literature]. 61
9339001 1997
10
[Bone metastasis of leiomyosarcoma. Apropos of a case]. 61
8560004 1995
11
Leiomyosarcoma of the middle ear and temporal bone. 61
8024216 1994
12
[Clinico-morphological indices for the differential diagnosis and prognosis of the course of a series of malignant tumors]. 61
2820146 1987
13
[Bone leiomyosarcoma of the pelvis]. 61
6880648 1983

Variations for Bone Leiomyosarcoma

Expression for Bone Leiomyosarcoma

Search GEO for disease gene expression data for Bone Leiomyosarcoma.

Pathways for Bone Leiomyosarcoma

Pathways related to Bone Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.09 APOBEC3B APOBEC3A

GO Terms for Bone Leiomyosarcoma

Cellular components related to Bone Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-body GO:0000932 8.62 APOBEC3B APOBEC3A

Biological processes related to Bone Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to virus GO:0051607 9.4 APOBEC3B APOBEC3A
2 DNA demethylation GO:0080111 9.37 APOBEC3B APOBEC3A
3 negative regulation of transposition GO:0010529 9.32 APOBEC3B APOBEC3A
4 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0045869 9.26 APOBEC3B APOBEC3A
5 cytidine to uridine editing GO:0016554 9.16 APOBEC3B APOBEC3A
6 cytidine deamination GO:0009972 8.96 APOBEC3B APOBEC3A
7 DNA cytosine deamination GO:0070383 8.62 APOBEC3B APOBEC3A

Molecular functions related to Bone Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytidine deaminase activity GO:0004126 8.96 APOBEC3B APOBEC3A
2 deoxycytidine deaminase activity GO:0047844 8.62 APOBEC3B APOBEC3A

Sources for Bone Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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