MCID: BNL001
MIFTS: 24

Bone Leiomyosarcoma

Categories: Bone diseases, Cancer diseases, Muscle diseases

Aliases & Classifications for Bone Leiomyosarcoma

MalaCards integrated aliases for Bone Leiomyosarcoma:

Name: Bone Leiomyosarcoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:3367
NCIt 49 C7154
UMLS 71 C1332579

Summaries for Bone Leiomyosarcoma

MalaCards based summary : Bone Leiomyosarcoma is related to giant cell tumor and leiomyosarcoma, and has symptoms including pain An important gene associated with Bone Leiomyosarcoma is CALD1 (Caldesmon 1), and among its related pathways/superpathways are Cytoskeletal Signaling and IL-6 signaling pathway. Affiliated tissues include bone, breast and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Bone Leiomyosarcoma

Diseases related to Bone Leiomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 136)
# Related Disease Score Top Affiliating Genes
1 giant cell tumor 29.7 TNFSF11 CD68
2 leiomyosarcoma 10.4
3 heart leiomyosarcoma 10.2 CD68 CALD1
4 intravascular fasciitis 10.2 CD68 CALD1
5 sarcomatoid squamous cell skin carcinoma 10.2 KRT5 CALD1
6 testicular fibroma 10.2 KRT5 CALD1
7 skin sarcoma 10.2 CD68 CALD1
8 vaginal endometrial stromal sarcoma 10.2 CD68 CALD1
9 extraosseous osteosarcoma 10.2 CD68 CALD1
10 congenital granular cell tumor 10.2 CD68 CALD1
11 villonodular synovitis 10.1 TNFSF11 CD68
12 multicentric reticulohistiocytosis 10.1 TNFSF11 CD68
13 conventional fibrosarcoma 10.1 CD68 CALD1
14 dermis tumor 10.1 CD68 CALD1
15 pseudosarcomatous fibromatosis 10.1 CD68 CALD1
16 giant cell reparative granuloma 10.1 TNFSF11 CD68
17 middle ear carcinoma 10.1 KRT5 CD68
18 connective tissue benign neoplasm 10.0 CD68 CALD1
19 bone giant cell tumor 10.0 TNFSF11 CD68
20 mesenchymal cell neoplasm 10.0 CD68 CALD1
21 pigmented villonodular synovitis 10.0 TNFSF11 CD68
22 nephrogenic adenofibroma 10.0 KRT7 CALD1
23 cervical adenoma malignum 10.0 KRT7 CALD1
24 vaginal benign neoplasm 9.9 KRT7 CALD1
25 sarcomatous intrahepatic cholangiocarcinoma 9.9 KRT7 CALD1
26 bladder leiomyoma 9.9 KRT7 CALD1
27 cardiomyopathy, infantile histiocytoid 9.9 MAPK14 CD68
28 cervical mucinous adenocarcinoma 9.9 KRT7 CALD1
29 adenomyoma 9.9 KRT7 CALD1
30 langerhans cell histiocytosis 9.9 TNFSF11 CD68
31 inverted transitional papilloma 9.9 KRT7 KRT5
32 skin benign neoplasm 9.9 KRT5 CD68
33 malignant spiradenoma 9.9 KRT7 KRT5
34 ceruminoma 9.9 KRT7 KRT5
35 ureter adenocarcinoma 9.9 KRT7 KRT5
36 benign breast adenomyoepithelioma 9.9 KRT7 KRT5
37 breast adenomyoepithelioma 9.9 KRT7 KRT5
38 adult mesoblastic nephroma 9.9 KRT7 CALD1
39 microinvasive cervical squamous cell carcinoma 9.9 KRT7 KRT5
40 fibroma 9.9 KRT7 CD68
41 ceruminous adenocarcinoma 9.9 KRT7 KRT5
42 vaginal cancer 9.9 KRT7 CALD1
43 external ear carcinoma 9.9 KRT7 KRT5
44 vulvar apocrine adenocarcinoma 9.9 KRT7 KRT5
45 apocrine adenocarcinoma 9.9 KRT7 KRT5
46 gastric squamous cell carcinoma 9.9 KRT7 KRT5
47 middle ear adenoma 9.9 KRT7 KRT5
48 epididymal neoplasm 9.9 KRT7 CD68
49 breast myoepithelial neoplasm 9.9 KRT7 KRT5
50 mediastinum sarcoma 9.9 KRT7 CD68

Graphical network of the top 20 diseases related to Bone Leiomyosarcoma:



Diseases related to Bone Leiomyosarcoma

Symptoms & Phenotypes for Bone Leiomyosarcoma

UMLS symptoms related to Bone Leiomyosarcoma:


pain

GenomeRNAi Phenotypes related to Bone Leiomyosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-142 9.4 TNFSF11
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.4 TNFSF11
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.4 KRT5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.4 KRT5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.4 TNFSF11
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.4 KRT7
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.4 KRT5 KRT7
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.4 KRT7
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.4 KRT5 KRT7 TNFSF11

Drugs & Therapeutics for Bone Leiomyosarcoma

Search Clinical Trials , NIH Clinical Center for Bone Leiomyosarcoma

Genetic Tests for Bone Leiomyosarcoma

Anatomical Context for Bone Leiomyosarcoma

MalaCards organs/tissues related to Bone Leiomyosarcoma:

40
Bone, Breast, Skin, Thymus, Heart, Liver, Lung

Publications for Bone Leiomyosarcoma

Articles related to Bone Leiomyosarcoma:

(show all 13)
# Title Authors PMID Year
1
Primary Leiomyosarcoma of Bone: Review and Update. 61
31661313 2019
2
Denosumab as a potential therapeutic option for leiomyosarcoma with osteoclast-like giant cells: A case report. 61
29387393 2018
3
Choroidal metastasis from primary bone leiomyosarcoma. 61
26109142 2015
4
Including MIR of a primary bone leiomyosarcoma that radiologically mimics a giant cell tumor. 61
18389991 2008
5
Lower gastrointestinal bleeding due to small bowel metastasis from leiomyosarcoma in the tibia. 61
17051843 2006
6
Subperiosteal leiomyosarcoma of the tibia. 61
15635482 2005
7
[Leiomyosarcoma of the bone.]. 61
20478187 2000
8
[Primary bone leiomyosarcoma. Anatomo-clinical, immunohistochemical, and ultrastructural study]. 61
10637889 1999
9
[Primary bone leiomyosarcoma. Anatomo-clinical case with immunohistochemistry study and review of the literature]. 61
9339001 1997
10
[Bone metastasis of leiomyosarcoma. Apropos of a case]. 61
8560004 1995
11
Leiomyosarcoma of the middle ear and temporal bone. 61
8024216 1994
12
[Clinico-morphological indices for the differential diagnosis and prognosis of the course of a series of malignant tumors]. 61
2820146 1987
13
[Bone leiomyosarcoma of the pelvis]. 61
6880648 1983

Variations for Bone Leiomyosarcoma

Expression for Bone Leiomyosarcoma

Search GEO for disease gene expression data for Bone Leiomyosarcoma.

Pathways for Bone Leiomyosarcoma

Pathways related to Bone Leiomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.29 KRT7 KRT5 CALD1
2
Show member pathways
11.09 TNFSF11 MAPK14
3 10.87 MAPK14 KRT5

GO Terms for Bone Leiomyosarcoma

Cellular components related to Bone Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratin filament GO:0045095 8.62 KRT7 KRT5

Biological processes related to Bone Leiomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 osteoclast differentiation GO:0030316 8.62 TNFSF11 MAPK14

Sources for Bone Leiomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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