MCID: BNL002
MIFTS: 32

Bone Lymphoma

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Bone Lymphoma

MalaCards integrated aliases for Bone Lymphoma:

Name: Bone Lymphoma 12 15
Lymphoma of the Bone 12
Lymphoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6759
NCIt 51 C6620
UMLS 74 C1332582

Summaries for Bone Lymphoma

Disease Ontology : 12 A bone cancer and lymphoma by site that results in lymphoma starting in the bone.

MalaCards based summary : Bone Lymphoma, also known as lymphoma of the bone, is related to lymphosarcoma and diffuse large b-cell lymphoma. An important gene associated with Bone Lymphoma is SMUG1 (Single-Strand-Selective Monofunctional Uracil-DNA Glycosylase 1), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone, b cells and bone marrow, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cellular

Related Diseases for Bone Lymphoma

Diseases in the Bone Lymphoma family:

Primary Bone Lymphoma

Diseases related to Bone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 lymphosarcoma 29.5 BCL6 CD22 CD79A SMUG1
2 diffuse large b-cell lymphoma 29.1 BCL6 CD79A
3 pediatric lymphoma 29.0 CD22 CD79A SMUG1
4 lymphoma, hodgkin, classic 28.9 BCL6 CD22 CD79A SMUG1
5 lymphoma, non-hodgkin, familial 28.9 BCL6 CD22 CD79A SMUG1
6 primary bone lymphoma 12.2
7 lymphoma 10.6
8 adult lymphoma 10.1 IFT172 SMUG1
9 central nervous system hematologic cancer 10.0 BCL6 SMUG1
10 mediastinal cancer 10.0 CD79A SMUG1
11 intestinal disease 9.9 BCL6 SMUG1
12 small intestine lymphoma 9.9 CD22 CD79A
13 b-cell lymphomas 9.9
14 mediastinal malignant lymphoma 9.9 BCL6 CD79A
15 marginal zone b-cell lymphoma 9.9 BCL6 CD79A
16 mature b-cell neoplasm 9.8 BCL6 CD79A
17 chronic recurrent multifocal osteomyelitis 9.8
18 adult t-cell leukemia 9.8
19 leukemia 9.8
20 t-cell leukemia 9.8
21 osteomyelitis 9.7
22 breast lymphoma 9.7 BCL6 CD79A SMUG1
23 lymphatic system cancer 9.7 BCL6 CD79A SMUG1
24 lymphoma, mucosa-associated lymphoid type 9.7 BCL6 CD79A SMUG1
25 meningioma, familial 9.7 MKI67 SMUG1
26 anemia, autoimmune hemolytic 9.7
27 follicular lymphoma 9.7
28 hemolytic anemia 9.7
29 mantle cell lymphoma 9.7
30 richter's syndrome 9.7
31 colon lymphoma 9.7 BCL6 CD22 CD79A
32 spondyloarthropathy 1 9.6
33 reticulum cell sarcoma 9.6
34 avascular necrosis of femoral head, primary, 1 9.6
35 anaplastic large cell lymphoma 9.6
36 pancytopenia 9.6
37 spondylitis 9.6
38 compartment syndrome 9.6
39 diabetes insipidus 9.6
40 osteochondroma 9.6
41 plasmablastic lymphoma 9.6
42 cytomegalic congenital adrenal hypoplasia 9.6
43 prostate cancer 9.6
44 rheumatoid arthritis 9.6
45 prostate cancer, hereditary, 8 9.6
46 prostate cancer, hereditary, 6 9.6
47 arthritis 9.6
48 sarcoma 9.6
49 cauda equina syndrome 9.6
50 patulous eustachian tube 9.6

Graphical network of the top 20 diseases related to Bone Lymphoma:



Diseases related to Bone Lymphoma

Symptoms & Phenotypes for Bone Lymphoma

GenomeRNAi Phenotypes related to Bone Lymphoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.8 BCL6 CD79A MKI67

MGI Mouse Phenotypes related to Bone Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.02 BCL6 CD22 CD79A IFT172 SMUG1

Drugs & Therapeutics for Bone Lymphoma

Search Clinical Trials , NIH Clinical Center for Bone Lymphoma

Genetic Tests for Bone Lymphoma

Anatomical Context for Bone Lymphoma

MalaCards organs/tissues related to Bone Lymphoma:

42
Bone, B Cells, Bone Marrow, Liver, Lymph Node, Prostate, Thyroid

Publications for Bone Lymphoma

Articles related to Bone Lymphoma:

(show top 50) (show all 118)
# Title Authors Year
1
A Rare Manifestation of Primary Bone Lymphoma: Solitary Diffuse Large B-Cell Lymphoma of the Little Finger. ( 29398333 )
2018
2
A Case of Extranodal Metastasis of Primary Bone Lymphoma in the Lower Extremity. ( 29547041 )
2018
3
Primary bone lymphoma: report of 7 cases. ( 29526308 )
2018
4
Prognostic Factors Associated with Bone Lymphoma Primarily Presenting in the Spine. ( 30096126 )
2018
5
PET/CT Imaging for Solitary Primary Bone Lymphoma of Thoracic Vertebra. ( 30222679 )
2018
6
Primary bone lymphoma: tunisian multicentric retrospective study about 32 cases. ( 30430499 )
2018
7
Extranodal Hodgkin Lymphoma of the Bone Marrow Without Lymphadenopathy and Unusual Cytogenetic Translocation. ( 29432307 )
2018
8
Challenges of assessing response to therapy in non-Hodgkin's lymphoma of the bone. ( 29666085 )
2018
9
Bone lymphoma with multiple negative bone biopsies. ( 28858013 )
2017
10
The role of 18F-FDG PET/CT in staging and restaging primary bone lymphoma. ( 28225435 )
2017
11
Prognostic relevance of protein expression, clinical factors, and<i>MYD88</i>mutation in primary bone lymphoma. ( 29029457 )
2017
12
Primary bone lymphoma of the talus: a challenging diagnosis. ( 28862737 )
2017
13
Case of polyostotic primary bone lymphoma successfully treated with immunochemotherapy and consolidation radiotherapy. ( 28249886 )
2017
14
Primary bone lymphoma presenting as skeletal lesions in a patient recently treated for prostate cancer. ( 29164979 )
2017
15
Primary bone lymphoma of radius and tibia: A case report and review of literature. ( 28403103 )
2017
16
Primary Bone Lymphoma Exhibits a Favorable Prognosis and Distinct Gene Expression Signatures Resembling Diffuse Large B-Cell Lymphoma Derived From Centrocytes in the Germinal Center. ( 28817403 )
2017
17
False Negative 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Primary B-cell Lymphoma of the Bone. ( 28553187 )
2017
18
Unexpected primary bone lymphoma. ( 27939644 )
2016
19
Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder Presenting as Primary Bone Lymphoma in a Patient with Rheumatoid Arthritis. ( 27523005 )
2016
20
Clinical characterization and outcome of primary bone lymphoma: a retrospective study of 61 Chinese patients. ( 27357354 )
2016
21
A rare case report of primary bone lymphoma and a brief review of the literature. ( 27563248 )
2016
22
Concomitant Classic Hodgkin Lymphoma of Lymph Node and cMYC-Positive Burkitt Leukemia/Lymphoma of the Bone Marrow Presented Concurrently at the Time of Presentation: A Rare Combination of Discordant Lymphomas. ( 27512341 )
2016
23
Complementary roles of bone scintigraphy and MR imaging in the detection and long-term follow-up of primary non-Hodgkin's bone lymphoma in a child-case report. ( 25433719 )
2015
24
Primary Bone Lymphoma: A Clinical Analysis of 17 Patients in a Single Institution. ( 25895753 )
2015
25
Utility of F-18 FDG PET/CT on the evaluation of primary bone lymphoma. ( 26388466 )
2015
26
Primary bone lymphoma with multifocal osteolytic lesions: a rare case report with review of literature. ( 26770955 )
2015
27
A treacherous case of primary non-Hodgkin lymphoma of the bone: appearances can be deceptive. ( 25784295 )
2015
28
Evaluation of primary bone lymphoma and the importance of positron emission tomography. ( 24901932 )
2014
29
Primary bone lymphoma - experience of oncological orthopaedics department in BrzozA^w. ( 25058108 )
2014
30
Results of a Prospective Study of High-Dose or Conventional Anthracycline-Cyclophosphamide Regimen Plus Radiotherapy for Localized Adult Non-Hodgkin's Primary Bone Lymphoma. ( 24723955 )
2014
31
Bone lymphoma revealed by cruralgia during pregnancy: a case report. ( 25419332 )
2014
32
18F-FDG PET/CT Demonstrating Primary Bone Lymphoma of the Extremities Mimicking an Inflammatory Peripheral Arthropathy. ( 25140543 )
2014
33
Incidental pedal manifestation of primary bone lymphoma: a case report. ( 24901590 )
2014
34
Prognostic significance of soft tissue extension, international prognostic index, and multifocality in primary bone lymphoma: a single institutional experience. ( 24673481 )
2014
35
Primary bone lymphoma of the left radius: a case report and related literature review. ( 24717101 )
2014
36
Clinical features, management and prognosis of multifocal primary bone lymphoma: a retrospective study of the international extranodal lymphoma study group (the IELSG 14 study). ( 24383942 )
2014
37
Primary bone lymphoma: A case report and review of the literature. ( 25202366 )
2014
38
Comment on: "clinical features, management, and prognosis of an international series of 161 patients with limited-stage diffuse large B-cell lymphoma of the bone (the IELSG-14 Study)". ( 25480339 )
2014
39
Primary diffuse large B-cell lymphoma of the bone: bendamustine and rituximab are able to overcome resistant disease. ( 25045615 )
2014
40
Clinical features, management, and prognosis of an international series of 161 patients with limited-stage diffuse large B-cell lymphoma of the bone (the IELSG-14 study). ( 24567283 )
2014
41
The clinical features, management and prognosis of primary and secondary indolent lymphoma of the bone: a retrospective study of the International Extranodal Lymphoma Study Group (IELSG #14 study). ( 24295130 )
2014
42
Primary bone lymphoma in a 10-year-old boy. ( 24617185 )
2013
43
Primary bone lymphoma: a retrospective analysis of 22 patients treated in a single tertiary center. ( 24008727 )
2013
44
Primary Bone Lymphoma of Humerus Diagnosed by FNAC- A Rare Case Report. ( 24426747 )
2013
45
Primary bone lymphoma with multiple vertebral involvement. ( 24125988 )
2013
46
Multifocal primary bone lymphoma: durable complete remission after R-CHOP chemotherapy. ( 23704456 )
2013
47
Primary diffuse large B-cell lymphoma of the bone marrow in a frail and elderly patient successfully treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. ( 24466557 )
2013
48
Clinical characteristics and outcomes of primary bone lymphoma in Korea. ( 23071477 )
2012
49
Primary bone lymphoma of the shoulder. ( 22812585 )
2012
50
Early-stage primary bone lymphoma: a retrospective, multicenter Rare Cancer Network (RCN) Study. ( 22079728 )
2012

Variations for Bone Lymphoma

Expression for Bone Lymphoma

Search GEO for disease gene expression data for Bone Lymphoma.

Pathways for Bone Lymphoma

GO Terms for Bone Lymphoma

Biological processes related to Bone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.62 BCL6 CD79A

Sources for Bone Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
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31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
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46 MESH via Orphanet
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50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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