MCID: BNL002
MIFTS: 34

Bone Lymphoma

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Bone Lymphoma

MalaCards integrated aliases for Bone Lymphoma:

Name: Bone Lymphoma 12 15
Lymphoma of the Bone 12
Lymphoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6759
NCIt 50 C6620
SNOMED-CT 67 766935007
UMLS 70 C1332582

Summaries for Bone Lymphoma

Disease Ontology : 12 A bone cancer and lymphoma by site that results in lymphoma starting in the bone.

MalaCards based summary : Bone Lymphoma, also known as lymphoma of the bone, is related to reticulum cell sarcoma and hodgkin's lymphoma, mixed cellularity. An important gene associated with Bone Lymphoma is IRF4 (Interferon Regulatory Factor 4), and among its related pathways/superpathways are T cell receptor signaling pathway and Immune response Fc epsilon RI pathway. Affiliated tissues include bone, bone marrow and breast, and related phenotypes are hematopoietic system and immune system

Related Diseases for Bone Lymphoma

Diseases in the Bone Lymphoma family:

Primary Bone Lymphoma

Diseases related to Bone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 reticulum cell sarcoma 30.2 TNFRSF8 PTPRC
2 hodgkin's lymphoma, mixed cellularity 30.0 TNFRSF8 SPN
3 plasmablastic lymphoma 29.8 PTPRC BCL6
4 t-cell lymphoblastic leukemia/lymphoma 29.8 TNFRSF8 PTPRC IRF4
5 anaplastic large cell lymphoma 29.8 TNFRSF8 PTPRC ALK
6 lymphosarcoma 29.7 TNFRSF8 PTPRC BCL6
7 hodgkin's lymphoma, lymphocytic-histiocytic predominance 29.5 TNFRSF8 PTPRC BCL6
8 reticulosarcoma 29.5 TNFRSF8 PTPRC BCL6 ALK
9 burkitt lymphoma 29.4 TNFRSF8 MME IRF4 BCL6
10 richter's syndrome 29.4 SPN IRF4 CD5
11 lymphoma, hodgkin, classic 29.3 TNFRSF8 PTPRC IRF4 BCL6 ALK
12 lymphoplasmacytic lymphoma 29.3 MME CD79A CD5 BCL6
13 lymphoma 29.1 TNFRSF8 PTPRC IRF4 CD5 BCL6 ALK
14 follicular lymphoma 29.0 MME IRF4 CD5 BCL6
15 ewing sarcoma 29.0 TNFRSF8 PTPRC ALK
16 myeloma, multiple 28.9 PTPRC IRF4 CD5 BCL6
17 t-cell adult acute lymphocytic leukemia 28.9 TNFRSF8 IRF4 CD5 ALK
18 b-cell lymphoma 28.9 TNFRSF8 PTPRC MME IRF4 CD5 BCL6
19 lymphoblastic lymphoma 28.8 TNFRSF8 PTPRC MME CD5 BCL6
20 composite lymphoma 28.8 TNFRSF8 MME CD79A CD5 BCL6
21 pediatric lymphoma 28.6 TNFRSF8 MME IRF4 CD79A BCL6 ALK
22 mantle cell lymphoma 28.6 SPN PTPRC MME CD5 BCL6
23 lymphoproliferative syndrome 28.3 TNFRSF8 PTPRC CD5 BCL6 ALK
24 immune deficiency disease 28.3 TNFRSF8 SPN PTPRC CD79A CD5 BCL6
25 adult lymphoma 28.3 TNFRSF8 MME IRF4 CD5 BCL6 ALK
26 mature t-cell and nk-cell lymphoma 28.1 TNFRSF8 MME CD79A CD5 BCL6 ALK
27 diffuse large b-cell lymphoma 28.0 TNFRSF8 SPN PTPRC MME IRF4 CD79A
28 leukemia, chronic lymphocytic 27.7 TNFRSF8 SPN PTPRC MME IRF4 CD79A
29 lymphoma, non-hodgkin, familial 27.5 TNFRSF8 SPN PTPRC MME IRF4 CD79A
30 mature b-cell neoplasm 27.5 TNFRSF8 SPN PTPRC MME IRF4 CD79A
31 primary bone lymphoma 11.2
32 primary mediastinal large b-cell lymphoma 10.2 IRF4 BCL6
33 hodgkin's lymphoma, lymphocytic depletion 10.2 TNFRSF8 CD79A
34 chest wall lymphoma 10.2 MME BCL6
35 ovarian lymphoma 10.2 MME BCL6
36 mediastinal malignant lymphoma 10.2 TNFRSF8 CD79A
37 mediastinal gray zone lymphoma 10.2 TNFRSF8 CD79A
38 retroperitoneal lymphoma 10.2 TNFRSF8 MME
39 hilar lung carcinoma 10.2 MME CD79A
40 lung hilum cancer 10.2 MME CD79A
41 extramedullary plasmacytoma 10.2 IRF4 CD79A
42 orbital cellulitis 10.1 TNFRSF8 MME
43 acute orbital inflammation 10.1 TNFRSF8 MME
44 liver lymphoma 10.1 MME CD79A
45 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.1 TNFRSF8 PTPRC
46 central epithelioid sarcoma 10.1 TNFRSF8 MME
47 vulvar proximal-type epithelioid sarcoma 10.1 TNFRSF8 MME
48 lethal midline granuloma 10.1 TNFRSF8 SPN
49 glomeruloid hemangioma 10.1 TNFRSF8 PTPRC
50 histiocytic and dendritic cell cancer 10.1 TNFRSF8 PTPRC

Graphical network of the top 20 diseases related to Bone Lymphoma:



Diseases related to Bone Lymphoma

Symptoms & Phenotypes for Bone Lymphoma

MGI Mouse Phenotypes related to Bone Lymphoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.7 BCL6 CD5 CD79A IRF4 PTPRC SPN
2 immune system MP:0005387 9.56 BCL6 CD5 CD79A IRF4 MME PTPRC
3 neoplasm MP:0002006 9.02 ALK CD79A IRF4 PTPRC SPN

Drugs & Therapeutics for Bone Lymphoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Pilot Survey to Assess International Travel Patterns and Risk Behaviour of Breast Cancer, Lymphoma Patients and Bone Marrow Transplant Recipients at Memorial Sloan-Kettering Cancer Center Completed NCT01111201

Search NIH Clinical Center for Bone Lymphoma

Genetic Tests for Bone Lymphoma

Anatomical Context for Bone Lymphoma

MalaCards organs/tissues related to Bone Lymphoma:

40
Bone, Bone Marrow, Breast, Lung, Prostate, Thymus, Myeloid

Publications for Bone Lymphoma

Articles related to Bone Lymphoma:

(show top 50) (show all 275)
# Title Authors PMID Year
1
Diffuse large B cell lymphoma presenting with renal failure and bone lesions in a 46-year-old woman: a case report and review of literature. 61
32989684 2021
2
Case report: Primary bone lymphoma presenting as a painful supraclavicular lump. 61
33552343 2021
3
[Adult non-Hodgkin bone lymphomas]. 61
33722379 2021
4
Primary sacral non-Hodgkin's lymphoma: report of a case and systematic review of literature. 61
33627139 2021
5
Challenges of interpreting the musculoskeletal manifestation of lymphoma: A case report. 61
32331926 2021
6
Primary bone lymphoma of the ilium successfully treated without radiation. 61
33363894 2020
7
Primary bone lymphoma: Clinical presentation and therapeutic considerations. 61
33083218 2020
8
Primary bone lymphoma: pictorial essay. 61
33304011 2020
9
The incidence and mortality trends of bone lymphoma in the United States: An analysis of the Surveillance, Epidemiology, and End Results database. 61
32760645 2020
10
18F-FDG PET/CT imaging for a solitary primary bone lymphoma of the maxilla. 61
33306767 2020
11
18F-FDG PET/CT imaging in a patient with solitary primary sacral lymphoma. 61
33306766 2020
12
Primary bone lymphoma of the thoracic vertebra in a patient with metastatic lung cancer. 61
32438255 2020
13
[Clinical features and imaging analysis of primary bone lymphoma of the jaw]. 61
32486567 2020
14
Primary Cranial Vault Non-Hodgkin's Lymphoma Mimicking Meningioma With Positive Angiography. 61
32754397 2020
15
Multiple osteolytic lesions due to Double-Expressor Primary non-Hodgkin Lymphoma of the Bone. 61
33344270 2020
16
Primary Bone Lymphoma in Axial Skeleton in a Middle-Aged Female Presented as Recurrent Anemia. 61
32308590 2020
17
Primary Bone Lymphoma: A Case Series and Review of Literature. 61
32328322 2020
18
A Nomogram Predicting Overall and Cancer-Specific Survival of Patients with Primary Bone Lymphoma: A Large Population-Based Study. 61
32884939 2020
19
Primary bone lymphoma of patella: A case report and review of literature. 61
31737136 2019
20
Non-Hodgkin Lymphoma with Synovial Involvement of the Knee. 61
31785142 2019
21
Non-Hodgkin's lymphoma and atypical neck pain: A case report. 61
28624375 2019
22
Beneficial effect of consolidative radiotherapy for patients with lymphoma and skeletal involvement. 61
31374054 2019
23
Next-generation sequencing-based characterization of the invasion by anatomical contiguity in a primary osseous diffuse large B-cell lymphoma. Correlation between the genetic profile of the malignancy and the clinical outcome of the patient. 61
30467824 2019
24
[Pathological Features, Treatment Options and Prognosis Assessment of Patients with Bone Lymphoma in Real-World]. 61
31204934 2019
25
Prognostic Factors Associated With Bone Lymphoma Primarily Presenting in the Spine. 61
30096126 2019
26
Osteolytic primary bone lymphoma in the multiple bones. 61
31656303 2019
27
Surgical Management of Primary Bone Lymphoma of the Hip: A Case Report and Review of the Literature. 61
30944745 2019
28
Primary Bone Lymphoma: A Rare Case of Anaplastic Large Cell Lymphoma in Calcaneus in a Child. 61
32405479 2019
29
Primary bone lymphoma: report of 7 cases. 61
29526308 2018
30
PET/CT Imaging for Solitary Primary Bone Lymphoma of Thoracic Vertebra. 61
30222679 2018
31
A Rare Manifestation of Primary Bone Lymphoma: Solitary Diffuse Large B-Cell Lymphoma of the Little Finger. 61
29398333 2018
32
ALK-positive anaplastic large-cell lymphoma with primary bone involvement: A rare case and review of the literature. 61
30173234 2018
33
The use of Deauville 5-point score could reduce the risk of false-positive fluorodeoxyglucose-positron emission tomography in the posttherapy evaluation of patients with primary bone lymphomas. 61
30034279 2018
34
Extranodal Hodgkin Lymphoma of the Bone Marrow Without Lymphadenopathy and Unusual Cytogenetic Translocation. 61
29432307 2018
35
Primary bone lymphoma presenting as skeletal lesions in a patient recently treated for prostate cancer. 61
29164979 2018
36
Primary bone lymphoma: tunisian multicentric retrospective study about 32 cases. 61
30430499 2018
37
Challenges of assessing response to therapy in non-Hodgkin's lymphoma of the bone. 61
29666085 2018
38
Primary non-Hodgkin lymphoma of the right femur and subsequent metastasis to the left femur: A case report and literature review. 61
29541210 2018
39
PRIMARY BONE LYMPHOMAS: RETROSPECTIVE ANALYSIS OF 42 CONSECUTIVE CASES. 61
29983626 2018
40
A Case of Extranodal Metastasis of Primary Bone Lymphoma in the Lower Extremity. 61
29547041 2018
41
Demographics and Outome in Paediatric Non-Hodgkin Lymphoma: Single Centre Experience at The Children Hospital Lahore, Pakistan. 61
29290192 2018
42
Primary Lymphoma of the Pelvis: A Case Report. 61
29600200 2017
43
Primary bone lymphoma of the talus: a challenging diagnosis. 61
28862737 2017
44
Primary malignant lymphoma of the talus: A case report and review of the literature. 61
28855991 2017
45
Primary Bone Lymphoma Exhibits a Favorable Prognosis and Distinct Gene Expression Signatures Resembling Diffuse Large B-Cell Lymphoma Derived From Centrocytes in the Germinal Center. 61
28817403 2017
46
Prognostic relevance of protein expression, clinical factors, and MYD88 mutation in primary bone lymphoma. 61
29029457 2017
47
Bone lymphoma with multiple negative bone biopsies. 61
28858013 2017
48
[Clinical features of 11 cases of primary bone lymphoma]. 61
28810328 2017
49
Percutaneous Vertebroplasty for Primary Non-Hodgkin's Lymphoma of the Thoracic Spine: Case Report and Review of the Literature. 61
28727717 2017
50
A case of HIV-negative plasmablastic lymphoma of the bone marrow with a unique immunophenotype. 61
28588836 2017

Variations for Bone Lymphoma

Expression for Bone Lymphoma

Search GEO for disease gene expression data for Bone Lymphoma.

Pathways for Bone Lymphoma

GO Terms for Bone Lymphoma

Cellular components related to Bone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.35 SPN PTPRC MME CD5 ALK
2 membrane raft GO:0045121 9.33 PTPRC MME CD79A
3 external side of plasma membrane GO:0009897 8.92 SPN PTPRC CD79A CD5

Biological processes related to Bone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.58 SPN PTPRC CD79A
2 T cell activation GO:0042110 9.37 PTPRC IRF4
3 positive regulation of B cell proliferation GO:0030890 9.32 PTPRC BCL6
4 B cell proliferation GO:0042100 9.26 PTPRC CD79A
5 positive regulation of interleukin-2 production GO:0032743 9.16 PTPRC IRF4
6 positive regulation of tumor necrosis factor production GO:0032760 9.13 TNFRSF8 SPN PTPRC
7 B cell differentiation GO:0030183 8.8 PTPRC CD79A BCL6

Molecular functions related to Bone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.8 TNFRSF8 SPN CD79A

Sources for Bone Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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