MCID: BNL002
MIFTS: 32

Bone Lymphoma

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Bone Lymphoma

MalaCards integrated aliases for Bone Lymphoma:

Name: Bone Lymphoma 12 15
Lymphoma of the Bone 12
Lymphoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6759
NCIt 51 C6620
UMLS 74 C1332582

Summaries for Bone Lymphoma

Disease Ontology : 12 A bone cancer and lymphoma by site that results in lymphoma starting in the bone.

MalaCards based summary : Bone Lymphoma, also known as lymphoma of the bone, is related to diffuse large b-cell lymphoma and lymphoma, hodgkin, classic. An important gene associated with Bone Lymphoma is IFT172 (Intraflagellar Transport 172), and among its related pathways/superpathways are Immune response Fc epsilon RI pathway and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include bone, b cells and prostate, and related phenotypes are Synthetic lethal with vaccinia virus (VACV) infection and cellular

Related Diseases for Bone Lymphoma

Diseases in the Bone Lymphoma family:

Primary Bone Lymphoma

Diseases related to Bone Lymphoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 diffuse large b-cell lymphoma 29.3 BCL6 CD79A
2 lymphoma, hodgkin, classic 29.1 BCL6 CD22 CD79A
3 pediatric lymphoma 29.1 CD22 CD79A
4 lymphoma, non-hodgkin, familial 29.1 BCL6 CD22 CD79A
5 lymphosarcoma 29.0 BCL6 CD22 CD79A
6 primary bone lymphoma 12.2
7 lymphoma 10.6
8 breast lymphoma 10.0 BCL6 CD79A
9 mediastinal malignant lymphoma 10.0 BCL6 CD79A
10 lymphatic system cancer 10.0 BCL6 CD79A
11 marginal zone b-cell lymphoma 9.9 BCL6 CD79A
12 mature b-cell neoplasm 9.9 BCL6 CD79A
13 lymphoma, mucosa-associated lymphoid type 9.8 BCL6 CD79A
14 small intestine lymphoma 9.8 CD22 CD79A
15 chronic recurrent multifocal osteomyelitis 9.8
16 adult t-cell leukemia 9.8
17 leukemia 9.8
18 t-cell leukemia 9.8
19 osteomyelitis 9.7
20 anemia, autoimmune hemolytic 9.7
21 follicular lymphoma 9.7
22 hemolytic anemia 9.7
23 mantle cell lymphoma 9.7
24 waldenstrom macroglobulinemia 9.7
25 richter's syndrome 9.7
26 spondyloarthropathy 1 9.6
27 reticulum cell sarcoma 9.6
28 avascular necrosis of femoral head, primary, 1 9.6
29 anaplastic large cell lymphoma 9.6
30 pancytopenia 9.6
31 spondylitis 9.6
32 compartment syndrome 9.6
33 diabetes insipidus 9.6
34 osteochondroma 9.6
35 plasmablastic lymphoma 9.6
36 prostate cancer 9.6
37 rheumatoid arthritis 9.6
38 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.6
39 prostate cancer, hereditary, 8 9.6
40 prostate cancer, hereditary, 6 9.6
41 arthritis 9.6
42 b-cell lymphomas 9.6
43 joint disorders 9.6
44 lymphoproliferative syndrome 9.6
45 sarcoma 9.6
46 cauda equina syndrome 9.6
47 patulous eustachian tube 9.6
48 mammary paget's disease 9.6
49 arthropathy 9.6
50 acquired immunodeficiency syndrome 9.6

Graphical network of the top 20 diseases related to Bone Lymphoma:



Diseases related to Bone Lymphoma

Symptoms & Phenotypes for Bone Lymphoma

GenomeRNAi Phenotypes related to Bone Lymphoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.8 BCL6 CD79A MKI67

MGI Mouse Phenotypes related to Bone Lymphoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.55 BCL6 CD22 CD79A EHD1 IFT172
2 no phenotypic analysis MP:0003012 9.26 BCL6 CD79A EHD1 MKI67
3 normal MP:0002873 8.92 BCL6 CD79A EHD1 MKI67

Drugs & Therapeutics for Bone Lymphoma

Search Clinical Trials , NIH Clinical Center for Bone Lymphoma

Genetic Tests for Bone Lymphoma

Anatomical Context for Bone Lymphoma

MalaCards organs/tissues related to Bone Lymphoma:

42
Bone, B Cells, Prostate, Bone Marrow, T Cells, Liver, Lymph Node

Publications for Bone Lymphoma

Articles related to Bone Lymphoma:

(show top 50) (show all 129)
# Title Authors Year
1
Prognostic Factors Associated With Bone Lymphoma Primarily Presenting in the Spine. ( 30096126 )
2019
2
Surgical Management of Primary Bone Lymphoma of the Hip: A Case Report and Review of the Literature. ( 30944745 )
2019
3
Primary bone lymphoma presenting as skeletal lesions in a patient recently treated for prostate cancer. ( 29164979 )
2018
4
A Rare Manifestation of Primary Bone Lymphoma: Solitary Diffuse Large B-Cell Lymphoma of the Little Finger. ( 29398333 )
2018
5
Primary bone lymphoma: report of 7 cases. ( 29526308 )
2018
6
A Case of Extranodal Metastasis of Primary Bone Lymphoma in the Lower Extremity. ( 29547041 )
2018
7
PET/CT Imaging for Solitary Primary Bone Lymphoma of Thoracic Vertebra. ( 30222679 )
2018
8
Primary bone lymphoma: tunisian multicentric retrospective study about 32 cases. ( 30430499 )
2018
9
Extranodal Hodgkin Lymphoma of the Bone Marrow Without Lymphadenopathy and Unusual Cytogenetic Translocation. ( 29432307 )
2018
10
Challenges of assessing response to therapy in non-Hodgkin's lymphoma of the bone. ( 29666085 )
2018
11
Unexpected primary bone lymphoma. ( 27939644 )
2017
12
The role of 18F-FDG PET/CT in staging and restaging primary bone lymphoma. ( 28225435 )
2017
13
Case of polyostotic primary bone lymphoma successfully treated with immunochemotherapy and consolidation radiotherapy. ( 28249886 )
2017
14
Primary bone lymphoma of radius and tibia: A case report and review of literature. ( 28403103 )
2017
15
Primary Bone Lymphoma Exhibits a Favorable Prognosis and Distinct Gene Expression Signatures Resembling Diffuse Large B-Cell Lymphoma Derived From Centrocytes in the Germinal Center. ( 28817403 )
2017
16
Bone lymphoma with multiple negative bone biopsies. ( 28858013 )
2017
17
Primary bone lymphoma of the talus: a challenging diagnosis. ( 28862737 )
2017
18
Prognostic relevance of protein expression, clinical factors, and MYD88 mutation in primary bone lymphoma. ( 29029457 )
2017
19
A case of HIV-negative plasmablastic lymphoma of the bone marrow with a unique immunophenotype. ( 28588836 )
2017
20
False Negative 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Primary B-cell Lymphoma of the Bone. ( 28553187 )
2017
21
Clinical characterization and outcome of primary bone lymphoma: a retrospective study of 61 Chinese patients. ( 27357354 )
2016
22
Other Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder Presenting as Primary Bone Lymphoma in a Patient with Rheumatoid Arthritis. ( 27523005 )
2016
23
A rare case report of primary bone lymphoma and a brief review of the literature. ( 27563248 )
2016
24
Concomitant Classic Hodgkin Lymphoma of Lymph Node and cMYC-Positive Burkitt Leukemia/Lymphoma of the Bone Marrow Presented Concurrently at the Time of Presentation: A Rare Combination of Discordant Lymphomas. ( 27512341 )
2016
25
18F-FDG PET/CT demonstrating primary bone lymphoma of the extremities mimicking an inflammatory peripheral arthropathy. ( 25140543 )
2015
26
Complementary roles of bone scintigraphy and MR imaging in the detection and long-term follow-up of primary non-Hodgkin's bone lymphoma in a child-case report. ( 25433719 )
2015
27
Stage IE Primary Bone Lymphoma:Limb Salvage for Local Recurrence. ( 25692168 )
2015
28
Primary Bone Lymphoma: A Clinical Analysis of 17 Patients in a Single Institution. ( 25895753 )
2015
29
Utility of F-18 FDG PET/CT on the evaluation of primary bone lymphoma. ( 26388466 )
2015
30
Primary bone lymphoma with multifocal osteolytic lesions: a rare case report with review of literature. ( 26770955 )
2015
31
A treacherous case of primary non-Hodgkin lymphoma of the bone: appearances can be deceptive. ( 25784295 )
2015
32
Incidental pedal manifestation of primary bone lymphoma: a case report. ( 24901590 )
2014
33
Evaluation of primary bone lymphoma and the importance of positron emission tomography. ( 24901932 )
2014
34
Primary bone lymphoma - experience of oncological orthopaedics department in Brzozów. ( 25058108 )
2014
35
Primary bone lymphoma: A case report and review of the literature. ( 25202366 )
2014
36
Bone lymphoma revealed by cruralgia during pregnancy: a case report. ( 25419332 )
2014
37
Clinical features, management and prognosis of multifocal primary bone lymphoma: a retrospective study of the international extranodal lymphoma study group (the IELSG 14 study). ( 24383942 )
2014
38
Prognostic significance of soft tissue extension, international prognostic index, and multifocality in primary bone lymphoma: a single institutional experience. ( 24673481 )
2014
39
Primary bone lymphoma of the left radius: a case report and related literature review. ( 24717101 )
2014
40
Results of a Prospective Study of High-Dose or Conventional Anthracycline-Cyclophosphamide Regimen Plus Radiotherapy for Localized Adult Non-Hodgkin's Primary Bone Lymphoma. ( 24723955 )
2014
41
Comment on: "clinical features, management, and prognosis of an international series of 161 patients with limited-stage diffuse large B-cell lymphoma of the bone (the IELSG-14 Study)". ( 25480339 )
2014
42
Primary diffuse large B-cell lymphoma of the bone: bendamustine and rituximab are able to overcome resistant disease. ( 25045615 )
2014
43
Clinical features, management, and prognosis of an international series of 161 patients with limited-stage diffuse large B-cell lymphoma of the bone (the IELSG-14 study). ( 24567283 )
2014
44
The clinical features, management and prognostic effects of pathological fractures in a multicenter series of 373 patients with diffuse large B-cell lymphoma of the bone. ( 24287938 )
2014
45
Primary cold agglutinin-associated lymphoproliferative disease: a B-cell lymphoma of the bone marrow distinct from lymphoplasmacytic lymphoma. ( 24143001 )
2014
46
The clinical features, management and prognosis of primary and secondary indolent lymphoma of the bone: a retrospective study of the International Extranodal Lymphoma Study Group (IELSG #14 study). ( 24295130 )
2014
47
Prognostic factors and treatment efficacy in patients with primary diffuse large B-cell lymphoma of the bone: single institute experience over 11 years. ( 24429447 )
2014
48
Multifocal primary bone lymphoma: durable complete remission after R-CHOP chemotherapy. ( 23704456 )
2013
49
Primary bone lymphoma: a retrospective analysis of 22 patients treated in a single tertiary center. ( 24008727 )
2013
50
Primary bone lymphoma with multiple vertebral involvement. ( 24125988 )
2013

Variations for Bone Lymphoma

Expression for Bone Lymphoma

Search GEO for disease gene expression data for Bone Lymphoma.

Pathways for Bone Lymphoma

GO Terms for Bone Lymphoma

Biological processes related to Bone Lymphoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 B cell differentiation GO:0030183 8.62 BCL6 CD79A

Sources for Bone Lymphoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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