MCID: BNM005
MIFTS: 26

Bone Marrow Necrosis

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Bone Marrow Necrosis

MalaCards integrated aliases for Bone Marrow Necrosis:

Name: Bone Marrow Necrosis 53

Classifications:



Summaries for Bone Marrow Necrosis

NIH Rare Diseases : 53 In bone marrow necrosis, there is poor circulation of oxygen and nutrients to the bone marrow cells, causing the cells to die. Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. Bone marrow necrosis often causes fever and bone pain, and is associated with blood cancers, in particular acute lymphoblastic leukemia (ALL) although it can be associated with other cancers and non-cancerous conditions (e.g., sickle cell anemia, tuberculosis, infection, and sepsis).

MalaCards based summary : Bone Marrow Necrosis is related to lymphocytic leukemia and leukemia, acute lymphoblastic. An important gene associated with Bone Marrow Necrosis is BMP6 (Bone Morphogenetic Protein 6), and among its related pathways/superpathways are Phospholipase-C Pathway and p70S6K Signaling. Affiliated tissues include bone, bone marrow and myeloid.

Related Diseases for Bone Marrow Necrosis

Diseases related to Bone Marrow Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 142)
# Related Disease Score Top Affiliating Genes
1 lymphocytic leukemia 10.6
2 leukemia, acute lymphoblastic 10.5
3 pancytopenia 10.5
4 sickle cell disease 10.5
5 leukemia 10.4
6 disseminated intravascular coagulation 10.4
7 acute leukemia 10.3
8 myeloid leukemia 10.3
9 leukemia, acute myeloid 10.3
10 thrombocytopenia 10.3
11 lymphoma 10.3
12 purpura 10.3
13 thrombotic thrombocytopenic purpura 10.2
14 antiphospholipid syndrome 10.2
15 sickle cell anemia 10.2
16 neutropenia 10.2
17 acute promyelocytic leukemia 10.2
18 avascular necrosis 10.1
19 myelofibrosis 10.1
20 myeloma, multiple 10.1
21 deficiency anemia 10.1
22 toxic shock syndrome 10.1
23 b-cell lymphoma 10.1
24 acute monoblastic leukemia 10.1
25 thrombotic microangiopathy 10.1
26 leukemia, acute monocytic 10.0
27 neuroblastoma 1 10.0
28 thalassemia 10.0
29 hemoglobinopathy 10.0
30 hemolytic anemia 10.0
31 monocytic leukemia 10.0
32 hematopoietic stem cell transplantation 10.0
33 colorectal cancer 9.9
34 lymphoma, hodgkin, classic 9.9
35 ocular motor apraxia 9.9
36 polycythemia vera 9.9
37 lymphoma, non-hodgkin, familial 9.9
38 gastrointestinal stromal tumor 9.9
39 gastric cancer 9.9
40 myelodysplastic syndrome 9.9
41 mantle cell lymphoma 9.9
42 childhood acute lymphocytic leukemia 9.9
43 respiratory failure 9.9
44 diarrhea 9.9
45 myeloproliferative neoplasm 9.9
46 adenocarcinoma 9.9
47 gastric adenocarcinoma 9.9
48 polycythemia 9.9
49 miliary tuberculosis 9.9
50 hypereosinophilic syndrome 9.9

Graphical network of the top 20 diseases related to Bone Marrow Necrosis:



Diseases related to Bone Marrow Necrosis

Symptoms & Phenotypes for Bone Marrow Necrosis

Drugs & Therapeutics for Bone Marrow Necrosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Intraosseous Administration of Hypertonic Saline in Acute Brain-injured Patients: A Prospective Case Series and Literature Review Completed NCT03276494 Phase 2 Hypertonic saline

Search NIH Clinical Center for Bone Marrow Necrosis

Genetic Tests for Bone Marrow Necrosis

Anatomical Context for Bone Marrow Necrosis

MalaCards organs/tissues related to Bone Marrow Necrosis:

41
Bone, Bone Marrow, Myeloid, Brain, Lung, B Cells, T Cells

Publications for Bone Marrow Necrosis

Articles related to Bone Marrow Necrosis:

(show top 50) (show all 340)
# Title Authors PMID Year
1
How I investigate bone marrow necrosis. 38
31424633 2019
2
Bone Marrow Necrosis in a Patient Following Blinatumomab Therapy. 38
31219910 2019
3
A case of bone marrow necrosis and fat embolism in a sickle-cell disease patient. 38
31219421 2019
4
Fat embolism syndrome due to bone marrow necrosis in patients with hemoglobinopathies: A life-threatening complication mimicking thrombotic thrombocytopenic purpura. 38
30479040 2019
5
[Hairy cell leukemia complicated by bone marrow necrosis following cladribine administration]. 38
31281144 2019
6
Sudden death caused by pulmonary fat embolism in a patient with miliary tuberculosis. 38
30863732 2019
7
Massive bone marrow necrosis revealing an HIV-related primary bone marrow lymphoma: a diagnostic challenge. 38
30293217 2019
8
Semaphorin-3A inhibits multiple myeloma progression in a mouse model. 38
30102336 2018
9
Bone marrow necrosis in neuroendocrine tumor of the thymus. 38
30349709 2018
10
Bone Marrow Necrosis in Sickle Cell-Beta Thalassemia Patient Mimicking Thrombotic Thrombocytopenic Purpura. 38
30373875 2018
11
Successful treatment of a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report. 38
30112174 2018
12
Unexplained pancytopenia in acute myeloid leukemia treatment. 38
30147892 2018
13
[Microarchitecture features and pathology of necrotic region in patients with steroid-induced and alcohol-induced osteonecrosis of femoral head]. 38
30129310 2018
14
Nivolumab-associated bone marrow necrosis. 38
29351576 2018
15
Bone marrow necrosis secondary to metastatic adenocarcinoma revealed by 18F-FDG PET/CT: A clinical case report. 38
29245317 2017
16
Prevention of glucocorticoid-associated osteonecrosis by intravenous administration of mesenchymal stem cells in a rabbit model. 38
29162088 2017
17
Successful treatment with rivaroxaban of cerebral venous thrombosis and bone marrow necrosis induced by pegaspargase: A case report and literature review. 38
29145310 2017
18
Bone marrow necrosis and fat embolism syndrome: a dreadful complication of hemoglobin sickle cell disease. 38
29259931 2017
19
Transcatheter arterial embolization of abnormal vessels as a treatment for lateral epicondylitis refractory to conservative treatment: a pilot study with a 2-year follow-up. 38
28734535 2017
20
Pathogenesis of Frog Virus 3 ( Ranavirus, Iridoviridae) Infection in Wood Frogs ( Rana sylvatica). 38
28060677 2017
21
Region specific Raman spectroscopy analysis of the femoral head reveals that trabecular bone is unlikely to contribute to non-traumatic osteonecrosis. 38
28273910 2017
22
A Fatal Case of Immune Hyperhemolysis with Bone Marrow Necrosis in a Patient with Sickle Cell Disease. 38
28286630 2017
23
Bone Marrow Necrosis in Newly Diagnosed Acute Leukemia: Two Case Reports and Review of the Literature. 38
28680961 2017
24
Extensive Bone Marrow Necrosis: Initial Presentation in Sickle Cell Anemia-A Case Report and Review of the Literature. 38
28695026 2017
25
Inside Out: Bone Marrow Necrosis and Fat Embolism Complicating Sickle-β+ Thalassemia. 38
27296331 2016
26
Fat Embolism Syndrome Secondary to Bone Marrow Necrosis in Patients with Hemoglobinopathies. 38
27598359 2016
27
Spinal bone marrow necrosis after retroperitoneal lymph node dissection. 38
26826345 2016
28
Bone Marrow Necrosis: An Unusual Initial Presentation of Sickle Cell Anemia. 38
27521319 2016
29
Extensive Bone Marrow Necrosis and Osteolytic Lesions in a Case of Acute Myeloid Leukemia Transformed from Polycythemia Vera. 38
27433418 2016
30
Multiple Myeloma: An Unusual Cause of Extensive Bone Marrow Necrosis. 38
27504393 2016
31
Histopathologic findings of spontaneous osteonecrosis of the knee at an early stage: a case report. 38
26768133 2016
32
Musculoskeletal manifestations of the antiphospholipid syndrome. 38
26923284 2016
33
Acute myeloid leukemia presenting with extensive bone marrow necrosis, leukemia cutis and testicular involvement: successful treatment with allogeneic hematopoietic stem cell transplantation. 38
26551781 2016
34
Novel Lesions of Bones and Joints Associated with Chikungunya Virus Infection in Two Mouse Models of Disease: New Insights into Disease Pathogenesis. 38
27182740 2016
35
Disseminated gastric carcinoma in disguise-presentation as microangiopathic haemolytic anemia with bone marrow necrosis. 38
28138574 2016
36
Donor cell leukemia with bone marrow necrosis. 38
27941282 2016
37
From Bone Marrow Necrosis to Gaucher Disease; A Long Way to Run. 38
26376635 2015
38
Bone Marrow Involvement in Unknown Acute Myeloid Leukemia Detected by 18F-FDG PET/MRI. 38
26204209 2015
39
Bone marrow necrosis in acute leukemia: Clinical characteristic and outcome. 38
26017166 2015
40
Analysis of the molecular mechanism underlying bone marrow necrosis with acute lymphoblastic leukemia. 38
26185062 2015
41
Extensive bone marrow necrosis resolved by allogeneic umbilical cord blood mesenchymal stem cell transplantation in a chronic myeloid leukemia patient. 38
25961769 2015
42
A review of blood diseases and cytopenias associated with human parvovirus B19 infection. 38
25962796 2015
43
Extensive Bone Marrow Necrosis in a Case of Acute Myeloid Leukemia Transformed from a Myeloproliferative Neoplasm. 38
26351444 2015
44
The "starfield" pattern of cerebral fat embolism from bone marrow necrosis in sickle cell crisis. 38
25829988 2015
45
Cardiovascular and pulmonary adverse events in patients treated with BCR-ABL inhibitors: Data from the FDA Adverse Event Reporting System. 38
25580915 2015
46
Bone marrow necrosis discovered in a patient with suspected thrombotic thrombocytopenic purpura. 38
25196665 2015
47
Bone marrow necrosis: ten-year retrospective review of bone marrow biopsy specimens. 38
25596246 2015
48
A young leukemic patient with unusual catastrophic intestinal complication. 38
25673592 2015
49
De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly. 38
26347832 2015
50
[Multiorgan failure after sickle cell vaso occlusive attack: integrated clinical and biological emergency]. 38
25336134 2014

Variations for Bone Marrow Necrosis

Expression for Bone Marrow Necrosis

Search GEO for disease gene expression data for Bone Marrow Necrosis.

Pathways for Bone Marrow Necrosis

GO Terms for Bone Marrow Necrosis

Biological processes related to Bone Marrow Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 8.96 TGFA BMP6
2 positive regulation of epithelial cell proliferation GO:0050679 8.62 TGFA BMP6

Molecular functions related to Bone Marrow Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.62 TGFA BMP6

Sources for Bone Marrow Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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