MCID: BNM005
MIFTS: 28

Bone Marrow Necrosis

Categories: Blood diseases, Bone diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Bone Marrow Necrosis

MalaCards integrated aliases for Bone Marrow Necrosis:

Name: Bone Marrow Necrosis 54

Classifications:



Summaries for Bone Marrow Necrosis

NIH Rare Diseases : 54 In bone marrow necrosis, there is poor circulation of oxygen and nutrients to the bone marrow cells, causing the cells to die. Bone marrow is the spongy tissue inside some of your bones, such as your hip and thigh bones. It contains immature cells, called stem cells. The stem cells can develop into the red blood cells that carry oxygen through your body, the white blood cells that fight infections, and the platelets that help with blood clotting. Bone marrow necrosis often causes fever and bone pain, and is associated with blood cancers, in particular acute lymphoblastic leukemia (ALL) although it can be associated with other cancers and non-cancerous conditions (e.g., sickle cell anemia, tuberculosis, infection, and sepsis).

MalaCards based summary : Bone Marrow Necrosis is related to leukemia and lymphoma. An important gene associated with Bone Marrow Necrosis is BMP6 (Bone Morphogenetic Protein 6), and among its related pathways/superpathways are Phospholipase-C Pathway and p70S6K Signaling. Affiliated tissues include bone, bone marrow and myeloid.

Related Diseases for Bone Marrow Necrosis

Diseases related to Bone Marrow Necrosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 leukemia 10.6
2 lymphoma 10.4
3 lymphocytic leukemia 10.3
4 leukemia, acute lymphoblastic 10.3
5 myeloid leukemia 10.2
6 thrombotic thrombocytopenic purpura 10.2
7 purpura 10.2
8 sickle cell disease 10.2
9 leukemia, acute myeloid 10.2
10 acute promyelocytic leukemia 10.2
11 sickle cell anemia 10.1
12 acute leukemia 10.1
13 disseminated intravascular coagulation 10.1
14 thalassemia 10.0
15 pancytopenia 10.0
16 myeloma, multiple 9.9
17 polycythemia vera 9.9
18 acute lymphoblastic leukemia, childhood 9.9
19 acute lymphocytic leukemia 9.9
20 antiphospholipid syndrome 9.9
21 polycythemia 9.9
22 miliary tuberculosis 9.9
23 leukemia, chronic lymphocytic 2 9.8
24 burkitt lymphoma 9.8
25 leukemia, acute monocytic 9.8
26 leukemia, chronic lymphocytic 9.8
27 systemic lupus erythematosus 9.8
28 medulloblastoma 9.8
29 prostate cancer 9.8
30 thrombophilia due to thrombin defect 9.8
31 lung cancer 9.8
32 lymphoma, hodgkin, classic 9.8
33 myelofibrosis 9.8
34 prostate cancer, hereditary, 8 9.8
35 lymphoma, non-hodgkin, familial 9.8
36 hypereosinophilic syndrome, idiopathic 9.8
37 prostate cancer, hereditary, 6 9.8
38 bone mineral density quantitative trait locus 15 9.8
39 gastric cancer 9.8
40 beta-thalassemia 9.8
41 b-cell lymphomas 9.8
42 follicular lymphoma 9.8
43 hematopoietic stem cell transplantation 9.8
44 lymphoid leukemia 9.8
45 mantle cell lymphoma 9.8
46 thrombosis 9.8
47 bone disease 9.8
48 adult acute monocytic leukemia 9.8
49 q fever 9.8
50 hemolytic-uremic syndrome 9.8

Graphical network of the top 20 diseases related to Bone Marrow Necrosis:



Diseases related to Bone Marrow Necrosis

Symptoms & Phenotypes for Bone Marrow Necrosis

Drugs & Therapeutics for Bone Marrow Necrosis

Search Clinical Trials , NIH Clinical Center for Bone Marrow Necrosis

Genetic Tests for Bone Marrow Necrosis

Anatomical Context for Bone Marrow Necrosis

MalaCards organs/tissues related to Bone Marrow Necrosis:

42
Bone, Bone Marrow, Myeloid, B Cells, Lung, Colon, T Cells

Publications for Bone Marrow Necrosis

Articles related to Bone Marrow Necrosis:

(show top 50) (show all 202)
# Title Authors Year
1
Nivolumab-associated bone marrow necrosis. ( 29351576 )
2018
2
Bone Marrow Necrosis in Sickle Cell-Beta Thalassemia Patient Mimicking Thrombotic Thrombocytopenic Purpura. ( 30373875 )
2018
3
Fat Embolism Syndrome due to Bone Marrow Necrosis in Patients with Hemoglobinopathies: A Life-threatening Complication Mimicking Thrombotic Thrombocytopenic Purpura. ( 30479040 )
2018
4
Successful treatment of a patient with Philadelphia chromosome-positive acute lymphoblastic leukemia complicated by bone marrow necrosis and acute renal insufficiency: A case report. ( 30112174 )
2018
5
Massive bone marrow necrosis revealing an HIV-related primary bone marrow lymphoma: a diagnostic challenge. ( 30293217 )
2018
6
Bone marrow necrosis in neuroendocrine tumor of the thymus. ( 30349709 )
2018
7
Bone Marrow Necrosis in Newly Diagnosed Acute Leukemia: Two Case Reports and Review of the Literature. ( 28680961 )
2017
8
Bone marrow necrosis and fat embolism syndrome: a dreadful complication of hemoglobin sickle cell disease. ( 29259931 )
2017
9
A Fatal Case of Immune Hyperhemolysis with Bone Marrow Necrosis in a Patient with Sickle Cell Disease. ( 28286630 )
2017
10
Extensive Bone Marrow Necrosis: Initial Presentation in Sickle Cell Anemia-A Case Report and Review of the Literature. ( 28695026 )
2017
11
Successful treatment with rivaroxaban of cerebral venous thrombosis and bone marrow necrosis induced by pegaspargase: A case report and literature review. ( 29145310 )
2017
12
Bone marrow necrosis secondary to metastatic adenocarcinoma revealed by 18F-FDG PET/CT: A clinical case report. ( 29245317 )
2017
13
Extensive Bone Marrow Necrosis and Osteolytic Lesions in a Case of Acute Myeloid Leukemia Transformed from Polycythemia Vera. ( 27433418 )
2016
14
Spinal bone marrow necrosis after retroperitoneal lymph node dissection. ( 26826345 )
2016
15
Inside Out: Bone Marrow Necrosis and Fat Embolism Complicating Sickle-I^+ Thalassemia. ( 27296331 )
2016
16
Bone Marrow Necrosis: An Unusual Initial Presentation of Sickle Cell Anemia. ( 27521319 )
2016
17
Disseminated gastric carcinoma in disguise-presentation as microangiopathic haemolytic anemia with bone marrow necrosis. ( 28138574 )
2016
18
Multiple Myeloma: An Unusual Cause of Extensive Bone Marrow Necrosis. ( 27504393 )
2016
19
Donor cell leukemia with bone marrow necrosis. ( 27941282 )
2016
20
Fat Embolism Syndrome Secondary to Bone Marrow Necrosis in Patients with Hemoglobinopathies. ( 27598359 )
2016
21
Acute myeloid leukemia presenting with extensive bone marrow necrosis, leukemia cutis and testicular involvement: successful treatment with allogeneic hematopoietic stem cell transplantation. ( 26551781 )
2015
22
Extensive Bone Marrow Necrosis in a Case of Acute Myeloid Leukemia Transformed from a Myeloproliferative Neoplasm. ( 26351444 )
2015
23
De Novo CD5 Negative Blastic Mantle Cell Lymphoma Presented with Massive Bone Marrow Necrosis without Adenopathy or Organomegaly. ( 26347832 )
2015
24
The "starfield" pattern of cerebral fat embolism from bone marrow necrosis in sickle cell crisis. ( 25829988 )
2015
25
Bone marrow necrosis in acute leukemia: Clinical characteristic and outcome. ( 26017166 )
2015
26
Analysis of the molecular mechanism underlying bone marrow necrosis with acute lymphoblastic leukemia. ( 26185062 )
2015
27
Bone marrow necrosis: ten-year retrospective review of bone marrow biopsy specimens. ( 25596246 )
2015
28
Extensive bone marrow necrosis resolved by allogeneic umbilical cord blood mesenchymal stem cell transplantation in a chronic myeloid leukemia patient. ( 25961769 )
2015
29
From Bone Marrow Necrosis To Gaucher Disease; A Long Way To Run. ( 26376635 )
2015
30
Bone marrow necrosis and fat embolism syndrome in sickle cell disease: increased susceptibility of patients with non-SS genotypes and a possible association with human parvovirus B19 infection. ( 24468004 )
2014
31
Bone marrow necrosis in an adult patient with precursor B-cell acute lymphoblastic leukaemia at the time of presentation. ( 24706707 )
2014
32
Bone marrow necrosis discovered in a patient with suspected thrombotic thrombocytopenic purpura. ( 25196665 )
2014
33
Early relapse of Burkitt lymphoma heralded by a bone marrow necrosis and numb chin syndrome successfully treated with allogeneic stem cell transplantation. ( 25068102 )
2014
34
Spinal bone marrow necrosis with vertebral compression fracture: differentiation of BMN from AVN. ( 24848671 )
2014
35
Bone marrow necrosis in de novo AML. ( 24822245 )
2014
36
Bone marrow necrosis and fat embolism: an autopsy report of a severe complication of hemoglobin SC disease. ( 28580322 )
2014
37
Bone marrow necrosis: a culture medium for bacteria. ( 24298566 )
2013
38
Bone marrow necrosis - initial presentation in sickle cell anemia. ( 24167641 )
2013
39
Acute myeloid leukaemia with mutated NPM1 presenting with extensive bone marrow necrosis and Charcot-Leyden crystals. ( 23884732 )
2013
40
A case of bone marrow necrosis of an idiopathic aetiology: the report of a rare entity with review of the literature. ( 23634411 )
2013
41
Multiorgan failure and bone marrow necrosis in three adults with sickle cell-I^+ -thalassemia. ( 22374850 )
2012
42
G-CSF-Associated Bone Marrow Necrosis in AML after Induction Chemotherapy. ( 22937323 )
2012
43
Bone marrow necrosis secondary to imatinib usage, mimicking spinal metastasis on magnetic resonance imaging and FDG-PET/CT. ( 22017257 )
2012
44
Bone marrow necrosis in a girl with Hodgkin's disease. ( 22773298 )
2012
45
Clostridium perfringens gangrenous cystitis with septic shock and bone marrow necrosis. ( 22797355 )
2012
46
Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report. ( 23057758 )
2012
47
Reversible bone marrow necrosis after all-trans retinoic acid induction therapy for acute promyelocytic leukaemia. ( 21753723 )
2011
48
Prevalence of bone marrow necrosis in Egyptian cancer patients referring to the National Cancer Institute. ( 22776813 )
2011
49
Bone regeneration post-bone marrow necrosis mimicking hyperparathyroid bone disease. ( 21461297 )
2011
50
Catastrophic antiphospholipid antibody syndrome with bone marrow necrosis: a rare complication. ( 21965704 )
2011

Variations for Bone Marrow Necrosis

Expression for Bone Marrow Necrosis

Search GEO for disease gene expression data for Bone Marrow Necrosis.

Pathways for Bone Marrow Necrosis

GO Terms for Bone Marrow Necrosis

Biological processes related to Bone Marrow Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 8.96 BMP6 TGFA
2 positive regulation of epithelial cell proliferation GO:0050679 8.62 BMP6 TGFA

Molecular functions related to Bone Marrow Necrosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 8.62 BMP6 TGFA

Sources for Bone Marrow Necrosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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