BMND3
MCID: BNM018
MIFTS: 31

Bone Mineral Density Quantitative Trait Locus 3 (BMND3)

Categories: Bone diseases, Fetal diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Bone Mineral Density Quantitative Trait Locus 3

MalaCards integrated aliases for Bone Mineral Density Quantitative Trait Locus 3:

Name: Bone Mineral Density Quantitative Trait Locus 3 58
Bone Mineral Density, Low, Susceptibility to 58
Bone Mineral Density, Low 58
Low Bone Mineral Density 6
Bmnd3 58

Classifications:



External Ids:

OMIM 58 606928

Summaries for Bone Mineral Density Quantitative Trait Locus 3

MalaCards based summary : Bone Mineral Density Quantitative Trait Locus 3, also known as bone mineral density, low, susceptibility to, is related to bone mineral density quantitative trait locus 17 and hypophosphatasia, childhood. An important gene associated with Bone Mineral Density Quantitative Trait Locus 3 is BMND3 (Bone Mineral Density Variability 3). The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, liver and ovary.

Description from OMIM: 606928

Related Diseases for Bone Mineral Density Quantitative Trait Locus 3

Diseases in the Bone Mineral Density Quantitative Trait Locus 18 family:

Bone Mineral Density Quantitative Trait Locus 4 Bone Mineral Density Quantitative Trait Locus 1
Bone Mineral Density Quantitative Trait Locus 2 Bone Mineral Density Quantitative Trait Locus 3
Bone Mineral Density Quantitative Trait Locus 5 Bone Mineral Density Quantitative Trait Locus 6
Bone Mineral Density Quantitative Trait Locus 7 Bone Mineral Density Quantitative Trait Locus 8
Bone Mineral Density Quantitative Trait Locus 9 Bone Mineral Density Quantitative Trait Locus 10
Bone Mineral Density Quantitative Trait Locus 11 Bone Mineral Density Quantitative Trait Locus 12
Bone Mineral Density Quantitative Trait Locus 13 Bone Mineral Density Quantitative Trait Locus 14
Bone Mineral Density Quantitative Trait Locus 15 Bone Mineral Density Quantitative Trait Locus 16
Bone Mineral Density Quantitative Trait Locus 17

Diseases related to Bone Mineral Density Quantitative Trait Locus 3 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 bone mineral density quantitative trait locus 17 11.7
2 hypophosphatasia, childhood 11.3
3 osteoporosis 11.1
4 arthritis 10.4
5 spondyloarthropathy 1 10.4
6 bone mineral density quantitative trait locus 15 10.4
7 liver disease 10.4
8 inflammatory bowel disease 10.4
9 spondylitis 10.4
10 bone mineral density quantitative trait locus 8 10.3
11 rheumatoid arthritis 10.3
12 nonalcoholic fatty liver disease 10.3
13 fatty liver disease 10.3
14 osteoporotic fracture 10.3
15 thalassemia 10.3
16 scoliosis, isolated 1 10.2
17 celiac disease 1 10.2
18 anorexia nervosa 10.2
19 beta-thalassemia 10.2
20 crohn's disease 10.2
21 scoliosis 10.2
22 idiopathic scoliosis 10.2
23 bone resorption disease 10.2
24 hypogonadism 10.2
25 hypogonadotropism 10.2
26 cystic fibrosis 10.2
27 leukemia 10.2
28 ulcerative colitis 10.2
29 colitis 10.2
30 juvenile rheumatoid arthritis 10.2
31 systemic lupus erythematosus 10.1
32 leukemia, acute lymphoblastic 10.1
33 global developmental delay, absent or hypoplastic corpus callosum, and dysmorphic facies 10.1
34 diabetes mellitus 10.1
35 end stage renal failure 10.1
36 osteonecrosis 10.1
37 spinal muscular atrophy 10.1
38 lymphocytic leukemia 10.1
39 primary hyperparathyroidism 10.1
40 spondyloarthropathy 10.1
41 hyperparathyroidism 10.1
42 amenorrhea 10.1
43 human immunodeficiency virus infectious disease 10.1
44 muscular atrophy 10.1
45 lupus erythematosus 10.1
46 achondroplasia 9.9
47 atherosclerosis susceptibility 9.9
48 biliary cirrhosis, primary, 1 9.9
49 pseudohypoaldosteronism, type iia 9.9
50 hypochondroplasia 9.9

Graphical network of the top 20 diseases related to Bone Mineral Density Quantitative Trait Locus 3:



Diseases related to Bone Mineral Density Quantitative Trait Locus 3

Symptoms & Phenotypes for Bone Mineral Density Quantitative Trait Locus 3

Clinical features from OMIM:

606928

Drugs & Therapeutics for Bone Mineral Density Quantitative Trait Locus 3

Drugs for Bone Mineral Density Quantitative Trait Locus 3 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational Not Applicable 1994-09-7, 94-09-7 2337
2
tannic acid Approved Not Applicable 1401-55-4
3
Calcium Approved, Nutraceutical Not Applicable 7440-70-2 271
4
Vitamin D Approved, Nutraceutical, Vet_approved Not Applicable 1406-16-2
5
Vitamin D3 Approved, Nutraceutical Not Applicable 67-97-0 5280795 6221
6
Ergocalciferol Approved, Nutraceutical Not Applicable 50-14-6 5280793
7 Calcium Supplement Not Applicable
8 Calcium, Dietary Not Applicable
9 Micronutrients Not Applicable
10 Calciferol Not Applicable
11 Bone Density Conservation Agents Not Applicable
12 Ergocalciferols Not Applicable
13 Vitamin D2 Not Applicable
14 Hormones Not Applicable
15 Nutrients Not Applicable
16 Trace Elements Not Applicable
17 Vitamins Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Assessment of Bone Mineral Density During Pregnancy Completed NCT02480023 Phase 1
2 Effects of Whole Body Vibration and Pilates on Bone Mineral Density in Postmenopausal Women Completed NCT02769143 Not Applicable
3 High-dose Vitamin D Supplementation for ADT-induced Side Effects Completed NCT02064946 Not Applicable
4 The Health of Competitive Fitness Athletes Completed NCT03007459

Search NIH Clinical Center for Bone Mineral Density Quantitative Trait Locus 3

Genetic Tests for Bone Mineral Density Quantitative Trait Locus 3

Anatomical Context for Bone Mineral Density Quantitative Trait Locus 3

MalaCards organs/tissues related to Bone Mineral Density Quantitative Trait Locus 3:

42
Bone, Liver, Ovary, Pituitary, Prostate, Brain, Monocytes

Publications for Bone Mineral Density Quantitative Trait Locus 3

Articles related to Bone Mineral Density Quantitative Trait Locus 3:

(show top 50) (show all 182)
# Title Authors Year
1
A TRAF6 genetic variant is associated with low bone mineral density in rheumatoid arthritis. ( 30506403 )
2019
2
Low Hemoglobin Is Associated With Low Bone Mineral Density and High Risk of Bone Fracture in Male Adults: A Retrospective Medical Record Review Study. ( 31081448 )
2019
3
Letter: nonalcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density. ( 30868628 )
2019
4
Letter: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density-authors' reply. ( 30868629 )
2019
5
Systematic review and meta-analysis: non-alcoholic fatty liver disease is associated with a history of osteoporotic fractures but not with low bone mineral density. ( 30600540 )
2019
6
Low bone mineral density is associated with an elevated risk of developing increased arterial stiffness: A 10-year follow-up of Japanese women from the Japanese Population-based Osteoporosis (JPOS) cohort study. ( 30502749 )
2019
7
Serum miR-21 expression correlates with radiographic progression but also low bone mineral density in patients with ankylosing spondylitis: a cross-sectional study. ( 30997863 )
2019
8
Low bone mineral density and renal malformation in Mexican patients with Turner syndrome are associated with single nucleotide variants in vitamin D-metabolism genes. ( 30887870 )
2019
9
Poor Vitamin K Status Is Associated With Low Bone Mineral Density and Increased Fracture Risk in End-Stage Renal Disease. ( 30427544 )
2019
10
A polymorphism rs6815464 in the macrophage erythroblast attacher gene is associated with low bone mineral density in postmenopausal Japanese women. ( 30890479 )
2019
11
Low Bone Mineral Density in Elite Female Athletes With a History of Secondary Amenorrhea in Their Teens. ( 29601346 )
2018
12
Administration of Intravenous Zoledronic Acid Every 3 Months vs. Annually in β-thalassemia Patients with Low Bone Mineral Density: a Retrospective Comparison of Efficacy. ( 30061760 )
2018
13
Zoledronic Acid for Treatment of Low Bone Mineral Density in Patients with Beta Thalassemia Major. ( 30369735 )
2018
14
Fractures and Low Bone Mineral Density in Patients with Beta Thalassemia Major. ( 29398822 )
2018
15
Low bone mineral density in ambulatory persons with cerebral palsy? A systematic review. ( 29783868 )
2018
16
Risk factors for low bone mineral density in pediatric inflammatory bowel disease: the positive role of physical activity. ( 29438136 )
2018
17
Assessment of the risk of low bone mineral density in premenopausal Japanese female patients with systemic lupus erythematosus. ( 29657446 )
2018
18
Imbalanced bone turnover markers and low bone mineral density in patients with osteonecrosis of the femoral head. ( 29589087 )
2018
19
Osteoporosis and low bone mineral density (osteopenia) in rural and remote Queensland. ( 30303279 )
2018
20
Safety of Zoledronic Acid in Patients with Thalassemia Associated Low Bone Mineral Density. ( 29622881 )
2018
21
Low Bone Mineral Density Is Not Associated with Subclinical Atherosclerosis: A Population-Based Study in Rural China. ( 30423564 )
2018
22
Risk of fracture and low bone mineral density in adults with inflammatory bowel diseases. A systematic literature review with meta-analysis. ( 29909470 )
2018
23
Association of Low Bone Mineral Density with Anti-Citrullinated Protein Antibody Positivity and Disease Activity in Established Rheumatoid Arthritis: Findings from a US Observational Cohort. ( 29368271 )
2018
24
Low bone mineral density risk factors and testing patterns in institutionalized adults with intellectual and developmental disabilities. ( 28247586 )
2018
25
Pharmacological treatment options for low Bone Mineral Density and secondary osteoporosis in Anorexia Nervosa: A systematic review of the literature. ( 28554377 )
2017
26
Low bone mineral density and the severity of cholestasis in biliary atresia. ( 28652893 )
2017
27
Prevalence and risk factors for low bone mineral density in ulcerative colitis. ( 28643272 )
2017
28
Significant liver fibrosis assessed using liver transient elastography is independently associated with low bone mineral density in patients with non-alcoholic fatty liver disease. ( 28759632 )
2017
29
Association between low bone mineral density and fibromyalgia: a meta-analysis. ( 28536824 )
2017
30
Risk of low bone mineral density in testicular germ cell cancer survivors: association with hypogonadism and treatment modality. ( 28591464 )
2017
31
Low bone mineral density in adolescents with leukemia after hematopoietic stem cell transplantation: prolonged steroid therapy for GvHD and endocrinopathy after hematopoietic stem cell transplantation might be major concerns? ( 27479687 )
2017
32
Impaired calcium sensing distinguishes primary hyperparathyroidism (PHPT) patients with low bone mineral density. ( 28764845 )
2017
33
Low bone mineral density and fractures are highly prevalent in pediatric patients with spinal muscular atrophy regardless of disease severity. ( 28258940 )
2017
34
Dual-energy X-ray Absorptiometry of Both Hips Helps Appropriate Diagnosis of Low Bone Mineral Density and Osteoporosis. ( 28698484 )
2017
35
Estradiol-loaded PLGA nanoparticles for improving low bone mineral density of cancellous bone caused by osteoporosis: Application of enhanced charged nanoparticles with iontophoresis. ( 28391082 )
2017
36
Determinants of low bone mineral density in premenopausal polycystic ovary syndrome patients. ( 27908213 )
2017
37
Bone edema on magnetic resonance imaging is highly associated with low bone mineral density in patients with ankylosing spondylitis. ( 29240803 )
2017
38
Efficacy and safety of medical therapy for low bone mineral density in patients with Crohn disease: A systematic review with network meta-analysis. ( 28296781 )
2017
39
Pediatric-onset inflammatory bowel disease poses risk for low bone mineral density at early adulthood. ( 28179094 )
2017
40
Low bone mineral density in achondroplasia and hypochondroplasia. ( 26716907 )
2016
41
Low bone mineral density is a common finding in patients with homocystinuria. ( 26689745 )
2016
42
Hyperuricemia protects against low bone mineral density, osteoporosis and fractures: a systematic review and meta-analysis. ( 27636234 )
2016
43
Efficacy of pamidronate in pediatric osteosarcoma patients with low bone mineral density. ( 27104175 )
2016
44
Prevalence and risk factors of low bone mineral density in psoriatic arthritis: A systematic review. ( 27346576 )
2016
45
Higher Level of Dickkopf-1 is Associated with Low Bone Mineral Density and Higher Prevalence of Vertebral Fractures in Patients with Ankylosing Spondylitis. ( 26645432 )
2016
46
Hearing loss in postmenopausal women with low bone mineral density. ( 26277375 )
2016
47
Prediction of low bone mineral density in patients with inflammatory bowel diseases. ( 27733909 )
2016
48
Two Rare Mutations in the COL1A2 Gene Associate With Low Bone Mineral Density and Fractures in Iceland. ( 26235824 )
2016
49
Reply: Low bone mineral density is a common feature of Zellweger spectrum disorders. ( 27331009 )
2016
50
LOW BONE MINERAL DENSITY AMONG PATIENTS WITH NEWLY DIAGNOSED RHEUMATOID ARTHRITIS. ( 27323588 )
2016

Variations for Bone Mineral Density Quantitative Trait Locus 3

ClinVar genetic disease variations for Bone Mineral Density Quantitative Trait Locus 3:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 BMP4 NM_001202.5(BMP4): c.614T> C (p.Val205Ala) single nucleotide variant Uncertain significance GRCh38 Chromosome 14, 53950645: 53950645
2 BMP4 NM_001202.5(BMP4): c.614T> C (p.Val205Ala) single nucleotide variant Uncertain significance GRCh37 Chromosome 14, 54417363: 54417363

Expression for Bone Mineral Density Quantitative Trait Locus 3

Search GEO for disease gene expression data for Bone Mineral Density Quantitative Trait Locus 3.

Pathways for Bone Mineral Density Quantitative Trait Locus 3

GO Terms for Bone Mineral Density Quantitative Trait Locus 3

Sources for Bone Mineral Density Quantitative Trait Locus 3

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....