MCID: BNS001
MIFTS: 29

Bone Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Osteosarcoma

MalaCards integrated aliases for Bone Osteosarcoma:

Name: Bone Osteosarcoma 12 15
Osteosarcoma of Bone 12 71
Primary Osteosarcoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3376
NCIt 49 C53707
UMLS 71 C0585442

Summaries for Bone Osteosarcoma

MalaCards based summary : Bone Osteosarcoma, also known as osteosarcoma of bone, is related to chondrosarcoma and histiocytoma. An important gene associated with Bone Osteosarcoma is MIR221 (MicroRNA 221), and among its related pathways/superpathways is DNA Damage Response. The drugs Calcium carbonate and Calcium have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and liver.

Related Diseases for Bone Osteosarcoma

Diseases related to Bone Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 chondrosarcoma 30.3 MDM2 EWSR1 CDK4
2 histiocytoma 30.3 MDM2 EWSR1 CDK4
3 askin's tumor 30.2 EWSR1 CD99
4 juxtacortical osteosarcoma 29.7 SNRNP25 SATB2 MDM2 COPS3 CDK4
5 ewing sarcoma 29.5 MDM2 EWSR1 CDK4 CD99 CCNB3 BCOR
6 small cell osteogenic sarcoma 28.3 SNRNP25 MIR7850 MIR6859-1 MIR6842 MIR5706 MIR221
7 primary bone cancer 11.3
8 ring chromosome 7 10.6 MDM2 CDK4
9 mediastinum liposarcoma 10.6 MDM2 CDK4
10 gastric liposarcoma 10.6 MDM2 CDK4
11 diffuse lipomatosis 10.6 MDM2 CDK4
12 extraskeletal mesenchymal chondrosarcoma 10.6 EWSR1 CD99
13 undifferentiated embryonal sarcoma of the liver 10.6 MDM2 CDK4
14 embryonal sarcoma 10.5 MDM2 CDK4
15 ewing sarcoma of bone 10.5 EWSR1 CD99
16 spindle cell liposarcoma 10.5 MDM2 CDK4
17 pediatric liposarcoma 10.5 MDM2 CDK4
18 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.5 EWSR1 CD99
19 infiltrating lipoma 10.5 MDM2 CDK4
20 lipoblastoma 10.5 MDM2 CDK4
21 mediastinum sarcoma 10.5 MDM2 CDK4
22 liposarcoma of bone 10.5 MDM2 CDK4
23 central nervous system mesenchymal non-meningothelial tumor 10.5 EWSR1 CD99
24 bone epithelioid hemangioma 10.5 EWSR1 COPS3
25 inflammatory mfh 10.5 MDM2 CDK4
26 sarcomatosis 10.5 EWSR1 CREB3L1
27 pancreas sarcoma 10.5 MDM2 CDK4
28 adult liposarcoma 10.5 MDM2 CDK4
29 soft tissue sarcoma 10.5 MDM2 EWSR1
30 paratesticular lipoma 10.5 MDM2 CDK4
31 lipoma of spermatic cord 10.5 MDM2 CDK4
32 pleomorphic lipoma 10.5 MDM2 CDK4
33 extraosseous osteosarcoma 10.5 MDM2 CDK4
34 mixed liposarcoma 10.5 MDM2 CDK4
35 spindle cell lipoma 10.5 MDM2 CD99
36 extraskeletal ewing sarcoma 10.5 EWSR1 CD99
37 bone giant cell sarcoma 10.5 USP6 MDM2
38 retroperitoneal sarcoma 10.5 MDM2 EWSR1 CDK4
39 embryonal rhabdomyosarcoma 10.5 MDM2 EWSR1 CDK4
40 ring chromosome 10.5 MDM2 EWSR1 CDK4
41 cellular myxoid liposarcoma 10.5 MDM2 EWSR1 CDK4
42 myxoid liposarcoma 10.5 MDM2 EWSR1 CDK4
43 liposarcoma 10.5 MDM2 EWSR1 CDK4
44 infiltrating angiolipoma 10.4 MDM2 CDK4
45 pleomorphic liposarcoma 10.4 MDM2 EWSR1 CDK4
46 well-differentiated liposarcoma 10.4 MDM2 EWSR1 CDK4
47 periosteal osteogenic sarcoma 10.4 SATB2 MDM2
48 lipomatosis, multiple 10.4 MDM2 EWSR1 CDK4
49 skeletal muscle cancer 10.4 MDM2 EWSR1 CD99
50 dedifferentiated liposarcoma 10.4 MDM2 CDK4

Graphical network of the top 20 diseases related to Bone Osteosarcoma:



Diseases related to Bone Osteosarcoma

Symptoms & Phenotypes for Bone Osteosarcoma

Drugs & Therapeutics for Bone Osteosarcoma

Drugs for Bone Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 13)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium carbonate Approved, Investigational Phase 1 471-34-1
2
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
3 Gastrointestinal Agents Phase 1
4 Plerixafor octahydrochloride Phase 1
5 Anti-Infective Agents Phase 1
6 Anti-Retroviral Agents Phase 1
7 Antiviral Agents Phase 1
8 Anti-Ulcer Agents Phase 1
9 Radiopharmaceuticals Phase 1
10 Calcium, Dietary Phase 1
11 Anti-HIV Agents Phase 1
12 Antacids Phase 1
13 Hormones Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Dose Finding Study of CycloSam® (153Sm-DOTMP) Combined With External Beam Radiotherapy to Treat High Risk Osteosarcoma and Other Solid Tumors Metastatic to Bone Not yet recruiting NCT03612466 Phase 1 153Sm-DOTMP;Calcium Carbonate;Mozobil;Neupogen Injectable Product
2 PNA-mediated Inhibition of the SENP1 Molecular Hub as a Potential Therapeutic Approach for the Suppression of Osteosarcoma Growth and Metastasis (PNA-OS) Not yet recruiting NCT03798587
3 Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone Terminated NCT00615628

Search NIH Clinical Center for Bone Osteosarcoma

Genetic Tests for Bone Osteosarcoma

Anatomical Context for Bone Osteosarcoma

MalaCards organs/tissues related to Bone Osteosarcoma:

40
Bone, Kidney, Liver, Breast, Eye, Lung, Testes

Publications for Bone Osteosarcoma

Articles related to Bone Osteosarcoma:

(show top 50) (show all 120)
# Title Authors PMID Year
1
The sensitivity, specificity, and diagnostic accuracy of whole-bone MRI for identifying skip metastases in appendicular osteosarcoma and Ewing sarcoma. 61
31900513 2020
2
Primary Osteosarcoma of the Breast with Extensive Chondroid Matrix in a Teenager Female Patient: The Paradoxical Diagnosis in Breast Mastopathy. 61
32021493 2020
3
Simultaneous co-localized super-resolution fluorescence microscopy and atomic force microscopy: combined SIM and AFM platform for the life sciences. 61
31980680 2020
4
In Vitro Antiproliferative Evaluation of Synthetic Meroterpenes Inspired by Marine Natural Products. 61
31817358 2019
5
Radiographic manifestations of fibroblastic osteosarcoma: A diagnostic challenge. 61
31583207 2019
6
Is there a role for chemotherapy after local relapse in high-grade osteosarcoma? 61
31058424 2019
7
Preparation of adriamycin gelatin microsphere-loaded decellularized periosteum that is cytotoxic to human osteosarcoma cells. 61
30480804 2019
8
Hierarchical microchannel architecture in chitosan/bioactive glass scaffolds via electrophoretic deposition positive-replica. 61
30786159 2019
9
Parallel Fourier ptychographic microscopy for high-throughput screening with 96 cameras (96 Eyes). 61
31366957 2019
10
Preparation and Evaluation of A Novel Liposomal Nano-Formulation in Metastatic Cancer Treatment Studies. 61
30825286 2019
11
Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture. 61
31107447 2019
12
Chondrosarcoma as inaugural manifestation of monostotic Paget's disease of Bone. 61
31455754 2019
13
Inter-rater Variability in the Interpretation of Pre and Post Contrast MRI for Pre-Surgical Evaluation of Osteosarcoma in Long Bones in Pediatric Patients and Young Adults. 61
30851887 2019
14
Role of the clock gene Period3 in the human cell-autonomous circadian clock. 61
30575220 2019
15
Jaw osteosarcoma models in mice: first description. 61
30813941 2019
16
Low-Grade Surface Osteosarcoma of the Temporal Bone in Paediatric Patients: A Case Report and Literature Review. 61
31263376 2019
17
In-vitro and in-vivo, cytotoxicity evaluation of cast functionally graded biomaterials for dental implantology. 61
30274137 2018
18
Systematic exploration of cell morphological phenotypes associated with a transcriptomic query. 61
30011038 2018
19
Sequence analysis of cell-free DNA derived from cultured human bone osteosarcoma (143B) cells. 61
30261820 2018
20
Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride. 61
29168913 2018
21
Redox-responsive microbeads containing thiolated pectin-doxorubicin conjugate inhibit tumor growth and metastasis: An in vitro and in vivo study. 61
29702240 2018
22
3D Interconnected Mesoporous Alumina with Loaded Hemoglobin as a Highly Active Electrochemical Biosensor for H2 O2. 61
29582579 2018
23
Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation. 61
29226320 2018
24
Activation of the complement system in an osteosarcoma cell line promotes angiogenesis through enhanced production of growth factors. 61
29615744 2018
25
Synthesis, characterization, and cytotoxic properties of mono- and di-nuclear cobalt(ii)-polypyridyl complexes. 61
29634060 2018
26
Primary Cutaneous Osteosarcoma. 61
29996033 2018
27
Aberration-corrected cryoimmersion light microscopy. 61
29358380 2018
28
[Extraskeletal osteosarcoma: nosologocal diversity, morphology, differential diagnosis, and features of metastasis]. 61
29927442 2018
29
Thiolated pectin-doxorubicin conjugates: Synthesis, characterization and anticancer activity studies. 61
28821097 2017
30
Novel Approach in the Use of Plasma Spray: Preparation of Bulk Titanium for Bone Augmentations. 61
28837101 2017
31
Surface roughness in action - Cells in opposition. 61
28482596 2017
32
In vitro biocompatibility of a ferrimagnetic glass-ceramic for hyperthermia application. 61
28183672 2017
33
Cytotoxic effect of ferrimagnetic glass-ceramic nanocomposites on bone osteosarcoma cells. 61
28152478 2017
34
In vitro kinetic investigations on the bioactivity and cytocompatibility of bioactive glasses prepared via melting and sol-gel techniques for bone regeneration applications. 61
28233761 2017
35
Multidisciplinary approach to osteosarcoma. 61
29182106 2016
36
High Relative Expression of Pannexin 3 (PANX3) in an Axillary Sweat Gland Carcinoma With Osteosarcomatous Transformation. 61
27391460 2016
37
Exploring the Limits of Cell Adhesion under Shear Stress within Physiological Conditions and beyond on a Chip. 61
27775638 2016
38
Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis. 61
27376491 2016
39
3-Butenyl isothiocyanate: a hydrolytic product of glucosinolate as a potential cytotoxic agent against human cancer cell lines. 61
27777449 2016
40
Vitamin-D receptor agonist calcitriol reduces calcification in vitro through selective upregulation of SLC20A2 but not SLC20A1 or XPR1. 61
27184385 2016
41
A new subtype of high-grade mandibular osteosarcoma with RASAL1/MDM2 amplification. 61
26997440 2016
42
Do Surgical Margins Affect Local Recurrence and Survival in Extremity, Nonmetastatic, High-grade Osteosarcoma? 61
26013153 2016
43
Primary Osteosarcoma of the Bone with Rhabdoid Features: A Rare, Previously Undescribed Primary Malignant Tumor of Bone. 61
28058126 2016
44
Salvage surgery and microsurgical reconstruction for recurrence of skull base osteosarcoma after carbon ion radiotherapy. 61
26663946 2015
45
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas? 61
26197952 2015
46
Mechanosensitive store-operated calcium entry regulates the formation of cell polarity. 61
25639747 2015
47
Long-term response of gemcitabine plus docetaxel chemotherapy regimen for extraskeletal osteosarcoma: A case report. 61
26137107 2015
48
Small cell osteosarcoma: clinicopathologic, immunohistochemical, and molecular analysis of 36 cases. 61
25723116 2015
49
Epiphyseal osteosarcoma revisited: four illustrative cases with unusual histopathology and literature review. 61
25244180 2015
50
[Osteosarcoma at a rare location: a case study]. 61
29927170 2015

Variations for Bone Osteosarcoma

Expression for Bone Osteosarcoma

Search GEO for disease gene expression data for Bone Osteosarcoma.

Pathways for Bone Osteosarcoma

Pathways related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.29 MIR221 MDM2 CDK4 CCNB3

GO Terms for Bone Osteosarcoma

Biological processes related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell cycle arrest GO:0071157 8.62 MDM2 CDK4

Sources for Bone Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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