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MCID: BNS001
MIFTS: 30

Bone Osteosarcoma

Categories: Bone diseases, Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Bone Osteosarcoma

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MalaCards integrated aliases for Bone Osteosarcoma:

Name: Bone Osteosarcoma 12 15
Osteosarcoma of Bone 12 73
Primary Osteosarcoma of Bone 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3376
NCIt 50 C53707
UMLS 73 C0585442
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Summaries for Bone Osteosarcoma

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MalaCards based summary : Bone Osteosarcoma, also known as osteosarcoma of bone, is related to fibrous dysplasia and primary bone cancer. An important gene associated with Bone Osteosarcoma is NKX3-2 (NK3 Homeobox 2), and among its related pathways/superpathways are Regulation of retinoblastoma protein and Integrated Cancer Pathway. The drugs Radium Ra 223 dichloride and Lithium carbonate have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and liver, and related phenotype is embryo.

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Related Diseases for Bone Osteosarcoma

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Diseases related to Bone Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 fibrous dysplasia 29.6 BGLAP SPARC
2 primary bone cancer 11.5
3 bone cancer 11.2
4 retroperitoneal sarcoma 10.2 BCOR MDM2
5 ring chromosome 7 10.2 CDK4 MDM2
6 undifferentiated embryonal sarcoma of the liver 10.2 CDK4 MDM2
7 embryonal sarcoma 10.2 CDK4 MDM2
8 infiltrating angiolipoma 10.2 CDK4 MDM2
9 spindle cell lipoma 10.2 CDK4 MDM2
10 cellular myxoid liposarcoma 10.2 CDK4 MDM2
11 myxoid liposarcoma 10.2 CDK4 MDM2
12 inflammatory mfh 10.2 CDK4 MDM2
13 lipoblastoma 10.2 CDK4 MDM2
14 atypical lipomatous tumor 10.1 CDK4 MDM2
15 mixed liposarcoma 10.1 CDK4 MDM2
16 periosteal chondrosarcoma 10.1 CDK4 MDM2
17 chondroid lipoma 10.1 CDK4 MDM2
18 spindle cell liposarcoma 10.1 CDK4 MDM2
19 ischemic fasciitis 10.1 CDK4 MDM2
20 well-differentiated liposarcoma 10.1 CDK4 MDM2
21 dedifferentiated liposarcoma 10.1 CDK4 MDM2
22 extraosseous osteosarcoma 10.1 MDM2 SPARC
23 infiltrating lipoma 10.1 CDK4 MDM2
24 lipomatosis, multiple 10.1 CDK4 MDM2
25 malignant fibroxanthoma 10.1 CDK4 MDM2
26 fibrosarcoma of bone 10.1 CDK4 MDM2
27 malignant mesenchymoma 10.1 CDK4 MDM2
28 small cell osteogenic sarcoma 10.1 BCOR SATB2
29 retinal cancer 10.1 CDK4 MDM2
30 connective tissue cancer 10.1 CDK4 MDM2
31 kidney clear cell sarcoma 10.1 BCOR SATB2
32 papillary cystadenocarcinoma 10.0 BGLAP SPARC
33 ocular cancer 10.0 CDK4 MDM2
34 small cell sarcoma 10.0 BCOR CDK4 MDM2
35 fibrosarcomatous osteosarcoma 10.0 BGLAP SPARC
36 osseous heteroplasia, progressive 10.0 BGLAP SPARC
37 grade iii astrocytoma 10.0 CDK4 MDM2
38 osteofibrous dysplasia 10.0 BGLAP SPARC
39 malignant fibrous histiocytoma of bone 10.0 BGLAP CDK4 MDM2
40 rhabdomyosarcoma 2 10.0 CDK4 MDM2
41 brittle bone disorder 9.9 BGLAP SPARC
42 inflammatory myofibroblastic tumor 9.9 CDK4 MDM2
43 paget's disease of bone 9.9
44 primary hyperparathyroidism 9.8
45 hyperparathyroidism 9.8
46 chondrosarcoma 9.7
47 osteogenic sarcoma 9.7
48 giant cell tumor 9.7
49 malignant giant cell tumor 9.7
50 fibrosarcoma 9.7

Graphical network of the top 20 diseases related to Bone Osteosarcoma:



Diseases related to Bone Osteosarcoma
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Symptoms & Phenotypes for Bone Osteosarcoma

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MGI Mouse Phenotypes related to Bone Osteosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.02 BCOR CDK4 MDM2 NKX3-2 SATB2
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Drugs & Therapeutics for Bone Osteosarcoma

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Drugs for Bone Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 350)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Radium Ra 223 dichloride Approved, Investigational Phase 4,Phase 1,Phase 2 444811-40-9
2
Lithium carbonate Approved Phase 4 554-13-2
3
Heparin Approved, Investigational Phase 4,Not Applicable 9005-49-6 772 46507594
4
Dalteparin Approved Phase 4,Not Applicable 9005-49-6
5
Enoxaparin Approved Phase 4 9005-49-6 772
6
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
7 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
9 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
10 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
12 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
13 Central Nervous System Depressants Phase 4,Phase 3,Phase 1
14 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
15 Psychotropic Drugs Phase 4,Phase 1
16 Antimanic Agents Phase 4,Phase 1
17 Tranquilizing Agents Phase 4,Phase 1
18 Antidepressive Agents Phase 4
19 Fibrinolytic Agents Phase 4,Not Applicable
20 calcium heparin Phase 4,Not Applicable
21 Anticoagulants Phase 4,Not Applicable
22 Heparin, Low-Molecular-Weight Phase 4,Not Applicable
23 Antipyretics Phase 4
24 Platelet Aggregation Inhibitors Phase 4
25
Zoledronic acid Approved Phase 2, Phase 3,Phase 3,Phase 1 118072-93-8 68740
26
Ifosfamide Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 3778-73-2 3690
27
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 15663-27-1 2767 441203 84093
28
Doxorubicin Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 23214-92-8 31703
29
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 1177-87-3
30
Gemcitabine Approved Phase 2, Phase 3,Phase 1,Not Applicable 95058-81-4 60750
31
Promethazine Approved, Investigational Phase 2, Phase 3 60-87-7 4927
32
Diphenhydramine Approved, Investigational Phase 2, Phase 3 147-24-0, 58-73-1 3100
33
Docetaxel Approved, Investigational Phase 2, Phase 3,Phase 1,Not Applicable 114977-28-5 148124
34
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 50-02-2 5743
35
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
36
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 57-22-7, 2068-78-2 5978
37
Dactinomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 50-76-0 457193 2019
38
Cobalt Approved, Experimental Phase 3,Phase 1,Phase 2 7440-48-4 104729
39
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 3375-50-6 598
40
Etoposide Approved Phase 3,Phase 1,Phase 2,Not Applicable 33419-42-0 36462
41
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 55-98-1 2478
42
Melphalan Approved Phase 3,Phase 2,Phase 1,Not Applicable 148-82-3 4053 460612
43
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 51-75-2 4033
44
Methotrexate Approved Phase 3,Phase 2,Phase 1,Not Applicable 59-05-2, 1959-05-2 126941
45
leucovorin Approved Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
46
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
47
Sirolimus Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 53123-88-9 46835353 6436030 5284616
48
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1 100286-90-6, 97682-44-5 60838
49
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
50
Sorafenib Approved, Investigational Phase 2, Phase 3,Phase 1 284461-73-0 216239 406563

Interventional clinical trials:

(show top 50) (show all 471)
# Name Status NCT ID Phase Drugs
1 Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma Recruiting NCT01669369 Phase 4 Lithium Carbonate;Placebo
2 Radium-223 Dichloride Long-term Follow-up Program Recruiting NCT02312960 Phase 4
3 Low Molecular Weight Heparin (LMWH) vs Aspirin for Venous Thromboembolism (VTE) Prophylaxis in Orthopaedic Oncology Enrolling by invitation NCT03244020 Phase 4 Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
4 Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma Unknown status NCT00691236 Phase 2, Phase 3 Zoledronic acid;Standard chemotherapy
5 A Clinical Trial on Efficacy and Safety for Lobaplatin and Gemcitabine in Combination With Docetaxel in the Second-line Treatments on Advanced Osteosarcoma Unknown status NCT02099396 Phase 2, Phase 3 Docetaxel+lobaplatin;Gemcitabine+lobaplatin
6 Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
7 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
8 Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy Completed NCT02711007 Phase 2, Phase 3 apatinib
9 Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children Completed NCT00180908 Phase 3 Etoposide, Ifosfamide, Methotrexate;Doxorubicin, Methotrexate
10 Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma Completed NCT01176981 Phase 3 High Dose Methotrexate
11 Osteosarcoma Study #2: A Randomized Trial of Pre-Surgical Chemotherapy vs. Immediate Surgery and Adjuvant Chemotherapy in the Treatment of Non-Metastatic Osteosarcoma. A Pediatric Oncology Group Phase III Study Completed NCT00001217 Phase 3 pre-surgical chemotherapy
12 Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma Completed NCT00002539 Phase 3 cisplatin;doxorubicin hydrochloride
13 Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Completed NCT00003937 Phase 3 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate
14 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
15 Ridaforolimus in Treatment of Sarcoma-SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus)(8669-011 AM6) Completed NCT00538239 Phase 3 ridaforolimus;Placebo
16 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
17 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
18 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
19 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
20 Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor Completed NCT00006734 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
21 ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma Recruiting NCT01459484 Phase 2, Phase 3 Mifamurtide arm
22 Study Comparing the Safety and Effectiveness of Magnetic Resonance Guided Focused Ultrasound (MRgFUS) and External Beam Radiation (EBRT) for Treatment of Metastatic Bone Tumors and Multiple Myeloma Recruiting NCT01091883 Phase 3
23 Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Recruiting NCT01479283 Phase 3 24-Hour Prophylactic Cefazolin* Antibiotic Regimen;5-Days Prophylactic Cefazolin* Antibiotic Regimen
24 Vigil + Irinotecan and Temozolomide in Ewing's Sarcoma Recruiting NCT03495921 Phase 3 Irinotecan;Temozolomide
25 Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma Recruiting NCT02063022 Phase 3 Standard treatment (as per protocol ISG SSG III);Intensified chemotherapy
26 Study in Localized and Disseminated Ewing Sarcoma Recruiting NCT00987636 Phase 3 Zoledronic acid;Busulfan;Treosulfan
27 Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Recruiting NCT02306161 Phase 3 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Vincristine Sulfate
28 Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Active, not recruiting NCT00134030 Phase 3 Cisplatin;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Methotrexate
29 Randomized Controlled Trial to Assess Blockade of Voltage Gated Sodium Channels During Surgery in Operable Breast Cancer Active, not recruiting NCT01916317 Phase 3 0.5% lignocaine 60mM
30 Co-treatment With GnRH Analogs on the Ovarian Reserve in Young Women Treated With Alkylating Agents for Cancer Active, not recruiting NCT02856048 Phase 2, Phase 3 Triptorelin (GnRHa) + Chemotherapy
31 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Active, not recruiting NCT01987596 Phase 3
32 Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Active, not recruiting NCT01231906 Phase 3 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Topotecan Hydrochloride;Vincristine Sulfate
33 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Suspended NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
34 Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma Terminated NCT00470223 Phase 3 cisplatin;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate;zoledronic acid
35 Enbrel Versus Placebo With Radiation Therapy to Combat Fatigue and Cachexia Terminated NCT00127387 Phase 2, Phase 3 Enbrel
36 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
37 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
38 Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients Withdrawn NCT01734863 Phase 3
39 Combination Chemotherapy With or Without Topotecan in Treating Patients With Newly Diagnosed Localized Ewing's Sarcoma Withdrawn NCT00334867 Phase 3 cyclophosphamide;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate
40 Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed Osteosarcoma Unknown status NCT01216826 Phase 2 Everolimus
41 A Study of Endostar Combined With Chemotherapy for Treatment of Osteosarcoma Unknown status NCT01002092 Phase 2 Chemotherapy;Endostar
42 Pilot Study of Curcumin Formulation and Ashwagandha Extract in Advanced Osteosarcoma Unknown status NCT00689195 Phase 1, Phase 2
43 Prospective Clinical Trial Evaluating Metronomic Chemotherapy in Patients With High-grade, Operable, Non-metastatic Osteosarcoma of the Extremity Unknown status NCT02273583 Phase 2 continuous oral cyclophosphamide and methotrexate
44 Pilot Study of Expanded , Activated Haploidentical Natural Killer Cell Infusions for Sarcomas Unknown status NCT02409576 Phase 1, Phase 2
45 Study of Vinorelbine and Cyclofosfamide Among Patients With Refractory Tumours or in Relapse Unknown status NCT00180947 Phase 2 Vinorelbine, cyclofosfamide
46 The Adoptive Immunotherapy for Solid Tumors Using Modified Autologous Cytokine-induced Killer Cells Unknown status NCT01868490 Phase 1, Phase 2 cytokine induced killer cells
47 Interferon Alfa and Thalidomide in Treating Patients With Soft Tissue Sarcoma or Bone Sarcoma Unknown status NCT00026416 Phase 2 thalidomide
48 Hematopoietic Stem Cell Transplantation From Human Leukocyte Antigen (HLA) Compatible Donor in Ewing Sarcomas and Soft Tissues Sarcomas Unknown status NCT00998361 Phase 2
49 Tandem Peripheral Blood Stem Cell (PBSC) Rescue for High Risk Solid Tumors Unknown status NCT00179816 Phase 1, Phase 2 High-Dose Chemotherapy with Tandem PBSC Rescue.
50 Trial With Gemcitabine and Rapamycin in Second Line of Metastatic Osteosarcoma Completed NCT02429973 Phase 2 Gemcitabine plus rapamycin

Search NIH Clinical Center for Bone Osteosarcoma

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Genetic Tests for Bone Osteosarcoma

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Anatomical Context for Bone Osteosarcoma

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MalaCards organs/tissues related to Bone Osteosarcoma:

41
Bone, Kidney, Liver
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Publications for Bone Osteosarcoma

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Articles related to Bone Osteosarcoma:

(show all 21)
# Title Authors Year
1
Sequence analysis of cell-free DNA derived from cultured human bone osteosarcoma (143B) cells. ( 30261820 )
2018
2
Cytotoxic effect of ferrimagnetic glass-ceramic nanocomposites on bone osteosarcoma cells. ( 28152478 )
2017
3
Orbital metastasis: a rare manifestation of scapular bone osteosarcoma. ( 25709781 )
2014
4
Expression of cyclooxygenase-2 in osteosarcoma of bone. ( 17536311 )
2007
5
Primary bone osteosarcoma in the pediatric age: state of the art. ( 16860938 )
2006
6
Ultrastructure of low-grade intraosseous osteosarcoma of bone: a comparative study with fibrous dysplasia and parosteal osteosarcoma. ( 16971354 )
2006
7
Osteosarcoma of bone in apatient with primary hyperparathyroidism: a case report. ( 12510819 )
2003
8
Endobronchial metastasis from osteosarcoma of bone: treatment with intraluminal radiotherapy. ( 10593811 )
1999
9
Osteosarcoma of bone. ( 9732564 )
1998
10
Small cell osteosarcoma of bone. Review of 72 cases. ( 9179055 )
1997
11
Treatment of a second bone osteosarcoma. 3 cases and an unusual MRI finding. ( 7976302 )
1994
12
Epithelioid osteosarcoma of bone. Immunocytochemical evidence suggesting divergent epithelial and mesenchymal differentiation in a primary osseous neoplasm. ( 7683966 )
1993
13
Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. ( 7503935 )
1993
14
Problems and pitfalls in the use of computed tomography for the local evaluation of long bone osteosarcoma: report on 30 cases. ( 3856325 )
1985
15
Computed tomography of long-bone osteosarcoma. ( 286376 )
1979
16
Long bone osteosarcoma in a rhesus monkey. ( 293317 )
1979
17
Osteosarcoma of bone and a consideration of prognostic variables. ( 273473 )
1978
18
Osteosarcoma of bone and its important recognizable varieties. ( 203202 )
1977
19
Primary osteosarcoma of bone. Clinicopathologic investigation of 243 cases, with necropsy studies in 54. ( 266360 )
1977
20
Malignant tumors primary in bone (osteosarcoma, chondrosarcoma, fibrosarcoma, malignant giant cell tumor). ( 5272232 )
1970
21
OSTEOSARCOMA OF BONE. ( 14119114 )
1964
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Variations for Bone Osteosarcoma

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Expression for Bone Osteosarcoma

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Search GEO for disease gene expression data for Bone Osteosarcoma.
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Pathways for Bone Osteosarcoma

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Pathways related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Regulation of retinoblastoma protein 1
11 BGLAP MDM2
2
Integrated Cancer Pathway 1
10.82 CDK4 MDM2
3
DNA damage_ATM/ATR regulation of G1/S checkpoint 22
10.6 CDK4 MDM2
4
Oncogene Induced Senescence 66
10.13 CDK4 MDM2
Sources

GO Terms for Bone Osteosarcoma

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Biological processes related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.8 BCOR MDM2 NKX3-2 SATB2
2 response to drug GO:0042493 9.69 BGLAP CDK4 MDM2
3 heart development GO:0007507 9.63 BCOR MDM2 SPARC
4 positive regulation of cell cycle GO:0045787 9.54 CDK4 MDM2
5 regulation of gene expression GO:0010468 9.54 CDK4 MDM2 SATB2
6 bone development GO:0060348 9.52 BGLAP SPARC
7 cellular response to organic substance GO:0071310 9.48 MDM2 SATB2
8 response to testosterone GO:0033574 9.43 BGLAP CDK4
9 odontogenesis GO:0042476 9.4 BCOR BGLAP
10 negative regulation of cell cycle arrest GO:0071157 9.32 CDK4 MDM2
11 response to lead ion GO:0010288 9.26 CDK4 SPARC
12 osteoblast development GO:0002076 9.16 BGLAP SATB2
13 response to gravity GO:0009629 8.96 BGLAP SPARC
14 cellular response to growth factor stimulus GO:0071363 8.8 BGLAP MDM2 SPARC
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Sources for Bone Osteosarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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