MCID: BNS001
MIFTS: 39

Bone Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Osteosarcoma

MalaCards integrated aliases for Bone Osteosarcoma:

Name: Bone Osteosarcoma 12 15
Osteosarcoma of Bone 12 74
Primary Osteosarcoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3376
NCIt 51 C53707
UMLS 74 C0585442

Summaries for Bone Osteosarcoma

MalaCards based summary : Bone Osteosarcoma, also known as osteosarcoma of bone, is related to small cell osteogenic sarcoma and fibrous dysplasia. An important gene associated with Bone Osteosarcoma is NKX3-2 (NK3 Homeobox 2), and among its related pathways/superpathways are Regulation of retinoblastoma protein and Integrated Cancer Pathway. The drugs Zoledronic Acid and Radium Ra 223 dichloride have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and t cells, and related phenotype is embryo.

Related Diseases for Bone Osteosarcoma

Diseases related to Bone Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 small cell osteogenic sarcoma 30.2 BCOR SATB2
2 fibrous dysplasia 29.5 BGLAP SPARC
3 juxtacortical osteosarcoma 29.0 CDK4 EMILIN1 MDM2 SATB2
4 primary bone cancer 11.5
5 bone cancer 11.2
6 retroperitoneal sarcoma 10.3 BCOR MDM2
7 ring chromosome 7 10.2 CDK4 MDM2
8 undifferentiated embryonal sarcoma of the liver 10.2 CDK4 MDM2
9 embryonal sarcoma 10.2 CDK4 MDM2
10 infiltrating angiolipoma 10.2 CDK4 MDM2
11 spindle cell lipoma 10.2 CDK4 MDM2
12 cellular myxoid liposarcoma 10.2 CDK4 MDM2
13 myxoid liposarcoma 10.2 CDK4 MDM2
14 inflammatory mfh 10.2 CDK4 MDM2
15 lipoblastoma 10.2 CDK4 MDM2
16 atypical lipomatous tumor 10.2 CDK4 MDM2
17 kidney clear cell sarcoma 10.2 BCOR SATB2
18 mixed liposarcoma 10.2 CDK4 MDM2
19 periosteal chondrosarcoma 10.2 CDK4 MDM2
20 chondroid lipoma 10.2 CDK4 MDM2
21 spindle cell liposarcoma 10.2 CDK4 MDM2
22 ischemic fasciitis 10.2 CDK4 MDM2
23 well-differentiated liposarcoma 10.2 CDK4 MDM2
24 dedifferentiated liposarcoma 10.2 CDK4 MDM2
25 infiltrating lipoma 10.2 CDK4 MDM2
26 lipomatosis, multiple 10.2 CDK4 MDM2
27 malignant fibroxanthoma 10.2 CDK4 MDM2
28 fibrosarcoma of bone 10.1 CDK4 MDM2
29 extraosseous osteosarcoma 10.1 MDM2 SPARC
30 malignant mesenchymoma 10.1 CDK4 MDM2
31 retinal cancer 10.1 CDK4 MDM2
32 connective tissue cancer 10.1 CDK4 MDM2
33 ocular cancer 10.1 CDK4 MDM2
34 grade iii astrocytoma 10.0 CDK4 MDM2
35 papillary cystadenocarcinoma 10.0 BGLAP SPARC
36 small cell sarcoma 10.0 BCOR CDK4 MDM2
37 rhabdomyosarcoma 2 10.0 CDK4 MDM2
38 fibrosarcomatous osteosarcoma 10.0 BGLAP SPARC
39 osseous heteroplasia, progressive 10.0 BGLAP SPARC
40 osteofibrous dysplasia 9.9 BGLAP SPARC
41 malignant fibrous histiocytoma of bone 9.9 BGLAP CDK4 MDM2
42 inflammatory myofibroblastic tumor 9.9 CDK4 MDM2
43 osteogenic sarcoma 9.9
44 mammary paget's disease 9.9
45 paget's disease of bone 9.9
46 brittle bone disorder 9.9 BGLAP SPARC
47 primary hyperparathyroidism 9.8
48 hyperparathyroidism 9.8
49 chondrosarcoma 9.8
50 giant cell tumor 9.8

Graphical network of the top 20 diseases related to Bone Osteosarcoma:



Diseases related to Bone Osteosarcoma

Symptoms & Phenotypes for Bone Osteosarcoma

MGI Mouse Phenotypes related to Bone Osteosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.02 BCOR CDK4 MDM2 NKX3-2 SATB2

Drugs & Therapeutics for Bone Osteosarcoma

Drugs for Bone Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 380)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zoledronic Acid Approved Phase 4,Phase 2,Phase 3,Phase 1 118072-93-8 68740
2
Radium Ra 223 dichloride Approved, Investigational Phase 4,Phase 1,Phase 2 444811-40-9
3
Lithium carbonate Approved Phase 4 554-13-2
4
Heparin Approved, Investigational Phase 4,Not Applicable 9005-49-6 46507594 772
5
Dalteparin Approved Phase 4,Not Applicable 9005-49-6
6
Enoxaparin Approved Phase 4 9005-49-6 772
7
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
8 Bone Density Conservation Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
9 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
10 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
12 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
13 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
14 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
15 Central Nervous System Depressants Phase 4,Phase 3,Phase 1
16 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
17 Tranquilizing Agents Phase 4,Phase 1
18 Antidepressive Agents Phase 4
19 Psychotropic Drugs Phase 4,Phase 1
20 Antimanic Agents Phase 4,Phase 1
21 Fibrinolytic Agents Phase 4,Not Applicable
22 Anticoagulants Phase 4,Not Applicable
23 calcium heparin Phase 4,Not Applicable
24 Heparin, Low-Molecular-Weight Phase 4,Not Applicable
25 Platelet Aggregation Inhibitors Phase 4
26 Antipyretics Phase 4
27
Doxorubicin Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 23214-92-8 31703
28
Ifosfamide Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 3778-73-2 3690
29
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 15663-27-1 2767 441203 84093
30
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 1177-87-3
31
Gemcitabine Approved Phase 2, Phase 3,Phase 1,Not Applicable 95058-81-4 60750
32
Docetaxel Approved, Investigational Phase 2, Phase 3,Phase 1,Not Applicable 114977-28-5 148124
33
Promethazine Approved, Investigational Phase 2, Phase 3 60-87-7 4927
34
Diphenhydramine Approved, Investigational Phase 2, Phase 3 147-24-0, 58-73-1 3100
35
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 50-02-2 5743
36
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
37
Sargramostim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 123774-72-1, 83869-56-1
38
Melphalan Approved Phase 3,Phase 2,Phase 1,Not Applicable 148-82-3 460612 4053
39
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 55-98-1 2478
40
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-18-0, 6055-19-2 2907
41
Etoposide Approved Phase 3,Phase 1,Phase 2,Not Applicable 33419-42-0 36462
42
Dactinomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 50-76-0 457193 2019
43
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 3375-50-6 598
44
Cobalt Approved, Experimental Phase 3,Phase 1,Phase 2 7440-48-4 104729
45
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
46
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 51-75-2 4033
47
leucovorin Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 58-05-9 143 6006
48
Methotrexate Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
49
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
50
Sirolimus Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 53123-88-9 46835353 5284616 6436030

Interventional clinical trials:

(show top 50) (show all 486)
# Name Status NCT ID Phase Drugs
1 Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma Recruiting NCT01669369 Phase 4 Lithium Carbonate;Placebo
2 Zoledronic Acid in Decrease the Lung Metastatic Rate of Osteosarcoma Recruiting NCT03932071 Phase 4 Zoledronic Acid
3 Radium-223 Dichloride Long-term Follow-up Program Recruiting NCT02312960 Phase 4
4 Low Molecular Weight Heparin (LMWH) vs Aspirin for Venous Thromboembolism (VTE) Prophylaxis in Orthopaedic Oncology Enrolling by invitation NCT03244020 Phase 4 Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
5 Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma Unknown status NCT00691236 Phase 2, Phase 3 Zoledronic acid;Standard chemotherapy
6 A Clinical Trial on Efficacy and Safety for Lobaplatin and Gemcitabine in Combination With Docetaxel in the Second-line Treatments on Advanced Osteosarcoma Unknown status NCT02099396 Phase 2, Phase 3 Docetaxel+lobaplatin;Gemcitabine+lobaplatin
7 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Unknown status NCT01987596 Phase 3
8 Study in Localized and Disseminated Ewing Sarcoma Unknown status NCT00987636 Phase 3 Zoledronic acid;Busulfan;Treosulfan
9 Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
10 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
11 ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma Completed NCT01459484 Phase 2, Phase 3 Mifamurtide arm
12 Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy Completed NCT02711007 Phase 2, Phase 3 apatinib
13 Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children Completed NCT00180908 Phase 3 Etoposide, Ifosfamide, Methotrexate;Doxorubicin, Methotrexate
14 Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma Completed NCT01176981 Phase 3 High Dose Methotrexate
15 Osteosarcoma Study #2: A Randomized Trial of Pre-Surgical Chemotherapy vs. Immediate Surgery and Adjuvant Chemotherapy in the Treatment of Non-Metastatic Osteosarcoma. A Pediatric Oncology Group Phase III Study Completed NCT00001217 Phase 3 pre-surgical chemotherapy
16 Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma Completed NCT00002539 Phase 3 cisplatin;doxorubicin hydrochloride
17 Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Completed NCT00003937 Phase 3 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate
18 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
19 Ridaforolimus in Treatment of Sarcoma-SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus)(8669-011 AM6) Completed NCT00538239 Phase 3 ridaforolimus;Placebo
20 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
21 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
22 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
23 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
24 Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma Completed NCT02063022 Phase 3 Standard treatment (as per protocol ISG SSG III);Intensified chemotherapy
25 Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor Completed NCT00006734 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
26 Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Recruiting NCT01479283 Phase 3 24-Hour Prophylactic Cefazolin* Antibiotic Regimen;5-Days Prophylactic Cefazolin* Antibiotic Regimen
27 Vigil + Irinotecan and Temozolomide in Ewing's Sarcoma Recruiting NCT03495921 Phase 3 Irinotecan;Temozolomide
28 Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Active, not recruiting NCT00134030 Phase 3 Cisplatin;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Methotrexate
29 Randomized Controlled Trial to Assess Blockade of Voltage Gated Sodium Channels During Surgery in Operable Breast Cancer Active, not recruiting NCT01916317 Phase 3 0.5% lignocaine 60mM
30 Co-treatment With GnRH Analogs on the Ovarian Reserve in Young Women Treated With Alkylating Agents for Cancer Active, not recruiting NCT02856048 Phase 2, Phase 3 Triptorelin (GnRHa) + Chemotherapy
31 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
32 Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Active, not recruiting NCT02306161 Phase 3 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Vincristine Sulfate
33 Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Active, not recruiting NCT01231906 Phase 3 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Topotecan Hydrochloride;Vincristine Sulfate
34 Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma Terminated NCT00470223 Phase 3 cisplatin;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate;zoledronic acid
35 Enbrel Versus Placebo With Radiation Therapy to Combat Fatigue and Cachexia Terminated NCT00127387 Phase 2, Phase 3 Enbrel
36 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
37 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
38 Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients Withdrawn NCT01734863 Phase 3
39 Combination Chemotherapy With or Without Topotecan in Treating Patients With Newly Diagnosed Localized Ewing's Sarcoma Withdrawn NCT00334867 Phase 3 cyclophosphamide;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate
40 Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed Osteosarcoma Unknown status NCT01216826 Phase 2 Everolimus
41 A Study of Endostar Combined With Chemotherapy for Treatment of Osteosarcoma Unknown status NCT01002092 Phase 2 Chemotherapy;Endostar
42 Pilot Study of Curcumin Formulation and Ashwagandha Extract in Advanced Osteosarcoma Unknown status NCT00689195 Phase 1, Phase 2
43 Apatinib Second Line Treatment for Advanced Osteosarcoma and Soft Tissue Sarcomas ,Openting ,Single Center, One-armed Clinical Study. Unknown status NCT03163381 Phase 2 Apatinib
44 Prospective Clinical Trial Evaluating Metronomic Chemotherapy in Patients With High-grade, Operable, Non-metastatic Osteosarcoma of the Extremity Unknown status NCT02273583 Phase 2 continuous oral cyclophosphamide and methotrexate
45 Study of Vinorelbine and Cyclofosfamide Among Patients With Refractory Tumours or in Relapse Unknown status NCT00180947 Phase 2 Vinorelbine, cyclofosfamide
46 The Adoptive Immunotherapy for Solid Tumors Using Modified Autologous Cytokine-induced Killer Cells Unknown status NCT01868490 Phase 1, Phase 2 cytokine induced killer cells
47 Interferon Alfa and Thalidomide in Treating Patients With Soft Tissue Sarcoma or Bone Sarcoma Unknown status NCT00026416 Phase 2 thalidomide
48 Hematopoietic Stem Cell Transplantation From Human Leukocyte Antigen (HLA) Compatible Donor in Ewing Sarcomas and Soft Tissues Sarcomas Unknown status NCT00998361 Phase 2
49 Tandem Peripheral Blood Stem Cell (PBSC) Rescue for High Risk Solid Tumors Unknown status NCT00179816 Phase 1, Phase 2 High-Dose Chemotherapy with Tandem PBSC Rescue.
50 Trial With Gemcitabine and Rapamycin in Second Line of Metastatic Osteosarcoma Completed NCT02429973 Phase 2 Gemcitabine plus rapamycin

Search NIH Clinical Center for Bone Osteosarcoma

Genetic Tests for Bone Osteosarcoma

Anatomical Context for Bone Osteosarcoma

MalaCards organs/tissues related to Bone Osteosarcoma:

42
Bone, Lung, T Cells, Brain, Testes, Nk Cells, Bone Marrow

Publications for Bone Osteosarcoma

Articles related to Bone Osteosarcoma:

(show all 21)
# Title Authors Year
1
Sequence analysis of cell-free DNA derived from cultured human bone osteosarcoma (143B) cells. ( 30261820 )
2018
2
Cytotoxic effect of ferrimagnetic glass-ceramic nanocomposites on bone osteosarcoma cells. ( 28152478 )
2017
3
Orbital metastasis: a rare manifestation of scapular bone osteosarcoma. ( 25709781 )
2014
4
Expression of cyclooxygenase-2 in osteosarcoma of bone. ( 17536311 )
2007
5
Primary bone osteosarcoma in the pediatric age: state of the art. ( 16860938 )
2006
6
Ultrastructure of low-grade intraosseous osteosarcoma of bone: a comparative study with fibrous dysplasia and parosteal osteosarcoma. ( 16971354 )
2006
7
Osteosarcoma of bone in apatient with primary hyperparathyroidism: a case report. ( 12510819 )
2003
8
Endobronchial metastasis from osteosarcoma of bone: treatment with intraluminal radiotherapy. ( 10593811 )
1999
9
Osteosarcoma of bone. ( 9732564 )
1998
10
Small cell osteosarcoma of bone. Review of 72 cases. ( 9179055 )
1997
11
Treatment of a second bone osteosarcoma. 3 cases and an unusual MRI finding. ( 7976302 )
1994
12
Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. ( 7503935 )
1993
13
Epithelioid osteosarcoma of bone. Immunocytochemical evidence suggesting divergent epithelial and mesenchymal differentiation in a primary osseous neoplasm. ( 7683966 )
1993
14
Problems and pitfalls in the use of computed tomography for the local evaluation of long bone osteosarcoma: report on 30 cases. ( 3856325 )
1985
15
Computed tomography of long-bone osteosarcoma. ( 286376 )
1979
16
Long bone osteosarcoma in a rhesus monkey. ( 293317 )
1979
17
Osteosarcoma of bone and a consideration of prognostic variables. ( 273473 )
1978
18
Osteosarcoma of bone and its important recognizable varieties. ( 203202 )
1977
19
Primary osteosarcoma of bone. Clinicopathologic investigation of 243 cases, with necropsy studies in 54. ( 266360 )
1977
20
Malignant tumors primary in bone (osteosarcoma, chondrosarcoma, fibrosarcoma, malignant giant cell tumor). ( 5272232 )
1970
21
OSTEOSARCOMA OF BONE. ( 14119114 )
1964

Variations for Bone Osteosarcoma

Expression for Bone Osteosarcoma

Search GEO for disease gene expression data for Bone Osteosarcoma.

Pathways for Bone Osteosarcoma

Pathways related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11 BGLAP MDM2
2 10.82 CDK4 MDM2
3 10.6 CDK4 MDM2
4 10.13 CDK4 MDM2

GO Terms for Bone Osteosarcoma

Biological processes related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.8 BCOR MDM2 NKX3-2 SATB2
2 response to drug GO:0042493 9.69 BGLAP CDK4 MDM2
3 heart development GO:0007507 9.63 BCOR MDM2 SPARC
4 positive regulation of cell cycle GO:0045787 9.54 CDK4 MDM2
5 regulation of gene expression GO:0010468 9.54 CDK4 MDM2 SATB2
6 bone development GO:0060348 9.52 BGLAP SPARC
7 cellular response to organic substance GO:0071310 9.48 MDM2 SATB2
8 response to testosterone GO:0033574 9.43 BGLAP CDK4
9 odontogenesis GO:0042476 9.4 BCOR BGLAP
10 negative regulation of cell cycle arrest GO:0071157 9.32 CDK4 MDM2
11 response to lead ion GO:0010288 9.26 CDK4 SPARC
12 osteoblast development GO:0002076 9.16 BGLAP SATB2
13 response to gravity GO:0009629 8.96 BGLAP SPARC
14 cellular response to growth factor stimulus GO:0071363 8.8 BGLAP MDM2 SPARC

Sources for Bone Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
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46 MESH via Orphanet
47 MGI
50 NCI
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56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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