MCID: BNS001
MIFTS: 33

Bone Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Osteosarcoma

MalaCards integrated aliases for Bone Osteosarcoma:

Name: Bone Osteosarcoma 12 15
Osteosarcoma of Bone 12 72
Primary Osteosarcoma of Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3376
NCIt 50 C53707
UMLS 72 C0585442

Summaries for Bone Osteosarcoma

MalaCards based summary : Bone Osteosarcoma, also known as osteosarcoma of bone, is related to small cell osteogenic sarcoma and malignant fibroxanthoma. An important gene associated with Bone Osteosarcoma is NKX3-2 (NK3 Homeobox 2), and among its related pathways/superpathways are Integrated Cancer Pathway and DNA damage_ATM/ATR regulation of G1/S checkpoint. The drugs Calcium carbonate and Calcium have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and liver, and related phenotype is embryo.

Related Diseases for Bone Osteosarcoma

Diseases related to Bone Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 small cell osteogenic sarcoma 30.5 SATB2 BCOR
2 malignant fibroxanthoma 30.1 MDM2 CDK4
3 fibrosarcomatous osteosarcoma 29.8 SPARC BGLAP
4 fibrous dysplasia 29.5 SPARC BGLAP
5 juxtacortical osteosarcoma 29.1 SATB2 MDM2 EMILIN1 CDK4
6 primary bone cancer 11.3
7 ring chromosome 7 10.5 MDM2 CDK4
8 undifferentiated embryonal sarcoma of the liver 10.5 MDM2 CDK4
9 embryonal sarcoma 10.5 MDM2 CDK4
10 infiltrating angiolipoma 10.5 MDM2 CDK4
11 spindle cell lipoma 10.5 MDM2 CDK4
12 inflammatory mfh 10.5 MDM2 CDK4
13 cellular myxoid liposarcoma 10.5 MDM2 CDK4
14 lipoblastoma 10.5 MDM2 CDK4
15 mixed liposarcoma 10.5 MDM2 CDK4
16 periosteal chondrosarcoma 10.5 MDM2 CDK4
17 chondroid lipoma 10.4 MDM2 CDK4
18 ischemic fasciitis 10.4 MDM2 CDK4
19 spindle cell liposarcoma 10.4 MDM2 CDK4
20 retroperitoneal sarcoma 10.4 MDM2 BCOR
21 osteogenic sarcoma 10.4
22 well-differentiated liposarcoma 10.4 MDM2 CDK4
23 dedifferentiated liposarcoma 10.4 MDM2 CDK4
24 extraosseous osteosarcoma 10.4 SPARC MDM2
25 infiltrating lipoma 10.4 MDM2 CDK4
26 lipomatosis, multiple 10.3 MDM2 CDK4
27 fibrosarcoma of bone 10.3 MDM2 CDK4
28 kidney clear cell sarcoma 10.3 SATB2 BCOR
29 malignant mesenchymoma 10.1 MDM2 CDK4
30 papillary cystadenocarcinoma 10.1 SPARC BGLAP
31 small cell sarcoma 10.1 MDM2 CDK4 BCOR
32 paget's disease of bone 10.1
33 retinal cancer 10.1 MDM2 CDK4
34 malignant fibrous histiocytoma of bone 10.0 MDM2 CDK4 BGLAP
35 osseous heteroplasia, progressive 10.0 SPARC BGLAP
36 osteofibrous dysplasia 9.9 SPARC BGLAP
37 connective tissue cancer 9.9 MDM2 CDK4
38 ewing sarcoma 9.8
39 askin's tumor 9.8
40 lymphoma 9.8
41 lymphoblastic lymphoma 9.8
42 primary hyperparathyroidism 9.8
43 hyperparathyroidism 9.8
44 carcinosarcoma 9.8
45 mesenchymal chondrosarcoma 9.8
46 adenoma 9.8
47 parathyroid adenoma 9.8
48 ewing's family of tumors 9.8
49 chondrosarcoma 9.8
50 bone cancer 9.8

Graphical network of the top 20 diseases related to Bone Osteosarcoma:



Diseases related to Bone Osteosarcoma

Symptoms & Phenotypes for Bone Osteosarcoma

MGI Mouse Phenotypes related to Bone Osteosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.1 BCOR CDK4 COPS3 MDM2 NKX3-2 SATB2

Drugs & Therapeutics for Bone Osteosarcoma

Drugs for Bone Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Calcium carbonate Approved, Investigational Phase 1 471-34-1
2
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
3 Gastrointestinal Agents Phase 1
4 Antacids Phase 1
5 Hormones Phase 1
6 Anti-Infective Agents Phase 1
7 Radiopharmaceuticals Phase 1
8 Anti-HIV Agents Phase 1
9 Plerixafor octahydrochloride Phase 1
10 Calcium, Dietary Phase 1
11 Anti-Retroviral Agents Phase 1
12 Anti-Ulcer Agents Phase 1
13 Antiviral Agents Phase 1
14 Bone Density Conservation Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Dose Finding Study of CycloSam® (153Sm-DOTMP) Combined With External Beam Radiotherapy to Treat High Risk Osteosarcoma and Other Solid Tumors Metastatic to Bone Not yet recruiting NCT03612466 Phase 1 153Sm-DOTMP;Calcium Carbonate;Mozobil;Neupogen Injectable Product
2 PNA-mediated Inhibition of the SENP1 Molecular Hub as a Potential Therapeutic Approach for the Suppression of Osteosarcoma Growth and Metastasis (PNA-OS) Not yet recruiting NCT03798587
3 Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone Terminated NCT00615628

Search NIH Clinical Center for Bone Osteosarcoma

Genetic Tests for Bone Osteosarcoma

Anatomical Context for Bone Osteosarcoma

MalaCards organs/tissues related to Bone Osteosarcoma:

41
Bone, Breast, Liver, Lung, Testes, Kidney, Eye

Publications for Bone Osteosarcoma

Articles related to Bone Osteosarcoma:

(show top 50) (show all 115)
# Title Authors PMID Year
1
Is there a role for chemotherapy after local relapse in high-grade osteosarcoma? 38
31058424 2019
2
Preparation of adriamycin gelatin microsphere-loaded decellularized periosteum that is cytotoxic to human osteosarcoma cells. 38
30480804 2019
3
Preparation and Evaluation of A Novel Liposomal Nano-Formulation in Metastatic Cancer Treatment Studies. 38
30825286 2019
4
Parallel Fourier ptychographic microscopy for high-throughput screening with 96 cameras (96 Eyes). 38
31366957 2019
5
Hierarchical microchannel architecture in chitosan/bioactive glass scaffolds via electrophoretic deposition positive-replica. 38
30786159 2019
6
Combining Non-reducing SDS-PAGE Analysis and Chemical Crosslinking to Detect Multimeric Complexes Stabilized by Disulfide Linkages in Mammalian Cells in Culture. 38
31107447 2019
7
Chondrosarcoma as inaugural manifestation of monostotic Paget's disease of Bone. 38
31266050 2019
8
Inter-rater Variability in the Interpretation of Pre and Post Contrast MRI for Pre-Surgical Evaluation of Osteosarcoma in Long Bones in Pediatric Patients and Young Adults. 38
30851887 2019
9
Role of the clock gene Period3 in the human cell-autonomous circadian clock. 38
30575220 2019
10
Jaw osteosarcoma models in mice: first description. 38
30813941 2019
11
Low-Grade Surface Osteosarcoma of the Temporal Bone in Paediatric Patients: A Case Report and Literature Review. 38
31263376 2019
12
In-vitro and in-vivo, cytotoxicity evaluation of cast functionally graded biomaterials for dental implantology. 38
30274137 2018
13
Systematic exploration of cell morphological phenotypes associated with a transcriptomic query. 38
30011038 2018
14
Sequence analysis of cell-free DNA derived from cultured human bone osteosarcoma (143B) cells. 38
30261820 2018
15
Synthesis, characterization, and biological properties of composites of hydroxyapatite and hexagonal boron nitride. 38
29168913 2018
16
Redox-responsive microbeads containing thiolated pectin-doxorubicin conjugate inhibit tumor growth and metastasis: An in vitro and in vivo study. 38
29702240 2018
17
3D Interconnected Mesoporous Alumina with Loaded Hemoglobin as a Highly Active Electrochemical Biosensor for H2 O2. 38
29582579 2018
18
Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation. 38
29226320 2018
19
Activation of the complement system in an osteosarcoma cell line promotes angiogenesis through enhanced production of growth factors. 38
29615744 2018
20
Synthesis, characterization, and cytotoxic properties of mono- and di-nuclear cobalt(ii)-polypyridyl complexes. 38
29634060 2018
21
Primary Cutaneous Osteosarcoma. 38
29996033 2018
22
Aberration-corrected cryoimmersion light microscopy. 38
29358380 2018
23
[Extraskeletal osteosarcoma: nosologocal diversity, morphology, differential diagnosis, and features of metastasis]. 38
29927442 2018
24
Thiolated pectin-doxorubicin conjugates: Synthesis, characterization and anticancer activity studies. 38
28821097 2017
25
Novel Approach in the Use of Plasma Spray: Preparation of Bulk Titanium for Bone Augmentations. 38
28837101 2017
26
Surface roughness in action - Cells in opposition. 38
28482596 2017
27
In vitro biocompatibility of a ferrimagnetic glass-ceramic for hyperthermia application. 38
28183672 2017
28
Cytotoxic effect of ferrimagnetic glass-ceramic nanocomposites on bone osteosarcoma cells. 38
28152478 2017
29
In vitro kinetic investigations on the bioactivity and cytocompatibility of bioactive glasses prepared via melting and sol-gel techniques for bone regeneration applications. 38
28233761 2017
30
Multidisciplinary approach to osteosarcoma. 38
29182106 2016
31
High Relative Expression of Pannexin 3 (PANX3) in an Axillary Sweat Gland Carcinoma With Osteosarcomatous Transformation. 38
27391460 2016
32
Exploring the Limits of Cell Adhesion under Shear Stress within Physiological Conditions and beyond on a Chip. 38
27775638 2016
33
Design and synthesis of pyrimidinyl acyl thioureas as novel Hsp90 inhibitors in invasive ductal breast cancer and its bone metastasis. 38
27376491 2016
34
3-Butenyl isothiocyanate: a hydrolytic product of glucosinolate as a potential cytotoxic agent against human cancer cell lines. 38
27777449 2016
35
Vitamin-D receptor agonist calcitriol reduces calcification in vitro through selective upregulation of SLC20A2 but not SLC20A1 or XPR1. 38
27184385 2016
36
A new subtype of high-grade mandibular osteosarcoma with RASAL1/MDM2 amplification. 38
26997440 2016
37
Do Surgical Margins Affect Local Recurrence and Survival in Extremity, Nonmetastatic, High-grade Osteosarcoma? 38
26013153 2016
38
Primary Osteosarcoma of the Bone with Rhabdoid Features: A Rare, Previously Undescribed Primary Malignant Tumor of Bone. 38
28058126 2016
39
Salvage surgery and microsurgical reconstruction for recurrence of skull base osteosarcoma after carbon ion radiotherapy. 38
26663946 2015
40
Should High-grade Extraosseous Osteosarcoma Be Treated With Multimodality Therapy Like Other Soft Tissue Sarcomas? 38
26197952 2015
41
Mechanosensitive store-operated calcium entry regulates the formation of cell polarity. 38
25639747 2015
42
Long-term response of gemcitabine plus docetaxel chemotherapy regimen for extraskeletal osteosarcoma: A case report. 38
26137107 2015
43
Small cell osteosarcoma: clinicopathologic, immunohistochemical, and molecular analysis of 36 cases. 38
25723116 2015
44
[Osteosarcoma at a rare location: a case study]. 38
29927170 2015
45
Epiphyseal osteosarcoma revisited: four illustrative cases with unusual histopathology and literature review. 38
25244180 2015
46
Orbital metastasis: a rare manifestation of scapular bone osteosarcoma. 38
25709781 2014
47
Diaphyseal osteosarcomas have distinct clinical features from metaphyseal osteosarcomas. 38
25037733 2014
48
Midurethral autologous fascial sling surgery with reconstruction of the lower abdominal wall using the tensor fascia lata muscle flap for post-hemipelvectomy stress urinary incontinence. 38
24954425 2014
49
Labial mucosa metastasis of fibule giant cell-rich osteosarcoma: an unusual presentation. 38
23616975 2013
50
Pathological fracture as the presenting feature in pediatric osteosarcoma. 38
23281226 2013

Variations for Bone Osteosarcoma

Expression for Bone Osteosarcoma

Search GEO for disease gene expression data for Bone Osteosarcoma.

Pathways for Bone Osteosarcoma

Pathways related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.82 MDM2 CDK4
2 10.6 MDM2 CDK4
3 10.13 MDM2 CDK4

GO Terms for Bone Osteosarcoma

Biological processes related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.63 SPARC MDM2 BCOR
2 regulation of gene expression GO:0010468 9.61 SATB2 MDM2 CDK4
3 cellular response to organic substance GO:0071310 9.48 SATB2 MDM2
4 response to testosterone GO:0033574 9.4 CDK4 BGLAP
5 odontogenesis GO:0042476 9.37 BGLAP BCOR
6 negative regulation of cell cycle arrest GO:0071157 9.32 MDM2 CDK4
7 response to lead ion GO:0010288 9.26 SPARC CDK4
8 osteoblast development GO:0002076 9.16 SATB2 BGLAP
9 response to gravity GO:0009629 8.96 SPARC BGLAP
10 cellular response to growth factor stimulus GO:0071363 8.8 SPARC MDM2 BGLAP

Sources for Bone Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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