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MCID: BNS001
MIFTS: 40

Bone Osteosarcoma

Categories: Bone diseases, Cancer diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Bone Osteosarcoma

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MalaCards integrated aliases for Bone Osteosarcoma:

Name: Bone Osteosarcoma 12 15
Osteosarcoma of Bone 12 74
Primary Osteosarcoma of Bone 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3376
NCIt 51 C53707
UMLS 74 C0585442
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Summaries for Bone Osteosarcoma

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MalaCards based summary : Bone Osteosarcoma, also known as osteosarcoma of bone, is related to fibrous dysplasia and primary bone cancer. An important gene associated with Bone Osteosarcoma is NKX3-2 (NK3 Homeobox 2), and among its related pathways/superpathways are Regulation of retinoblastoma protein and Integrated Cancer Pathway. The drugs Radium Ra 223 dichloride and Lithium carbonate have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and t cells, and related phenotype is embryo.

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Related Diseases for Bone Osteosarcoma

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Diseases related to Bone Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 fibrous dysplasia 29.5 BGLAP SPARC
2 primary bone cancer 11.5
3 bone cancer 11.2
4 retroperitoneal sarcoma 10.3 BCOR MDM2
5 small cell osteogenic sarcoma 10.2 BCOR SATB2
6 ring chromosome 7 10.2 CDK4 MDM2
7 undifferentiated embryonal sarcoma of the liver 10.2 CDK4 MDM2
8 embryonal sarcoma 10.2 CDK4 MDM2
9 infiltrating angiolipoma 10.2 CDK4 MDM2
10 spindle cell lipoma 10.2 CDK4 MDM2
11 cellular myxoid liposarcoma 10.2 CDK4 MDM2
12 myxoid liposarcoma 10.2 CDK4 MDM2
13 inflammatory mfh 10.2 CDK4 MDM2
14 lipoblastoma 10.2 CDK4 MDM2
15 atypical lipomatous tumor 10.2 CDK4 MDM2
16 kidney clear cell sarcoma 10.2 BCOR SATB2
17 mixed liposarcoma 10.2 CDK4 MDM2
18 periosteal chondrosarcoma 10.2 CDK4 MDM2
19 chondroid lipoma 10.2 CDK4 MDM2
20 spindle cell liposarcoma 10.2 CDK4 MDM2
21 ischemic fasciitis 10.2 CDK4 MDM2
22 well-differentiated liposarcoma 10.2 CDK4 MDM2
23 dedifferentiated liposarcoma 10.2 CDK4 MDM2
24 infiltrating lipoma 10.2 CDK4 MDM2
25 lipomatosis, multiple 10.2 CDK4 MDM2
26 malignant fibroxanthoma 10.1 CDK4 MDM2
27 fibrosarcoma of bone 10.1 CDK4 MDM2
28 extraosseous osteosarcoma 10.1 MDM2 SPARC
29 malignant mesenchymoma 10.1 CDK4 MDM2
30 retinal cancer 10.1 CDK4 MDM2
31 connective tissue cancer 10.1 CDK4 MDM2
32 ocular cancer 10.0 CDK4 MDM2
33 grade iii astrocytoma 10.0 CDK4 MDM2
34 papillary cystadenocarcinoma 10.0 BGLAP SPARC
35 small cell sarcoma 10.0 BCOR CDK4 MDM2
36 rhabdomyosarcoma 2 10.0 CDK4 MDM2
37 fibrosarcomatous osteosarcoma 10.0 BGLAP SPARC
38 osseous heteroplasia, progressive 10.0 BGLAP SPARC
39 osteofibrous dysplasia 9.9 BGLAP SPARC
40 malignant fibrous histiocytoma of bone 9.9 BGLAP CDK4 MDM2
41 inflammatory myofibroblastic tumor 9.9 CDK4 MDM2
42 paget's disease of bone 9.9
43 brittle bone disorder 9.9 BGLAP SPARC
44 primary hyperparathyroidism 9.8
45 hyperparathyroidism 9.8
46 chondrosarcoma 9.8
47 osteogenic sarcoma 9.8
48 giant cell tumor 9.8
49 malignant giant cell tumor 9.8
50 fibrosarcoma 9.8

Graphical network of the top 20 diseases related to Bone Osteosarcoma:



Diseases related to Bone Osteosarcoma
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Symptoms & Phenotypes for Bone Osteosarcoma

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MGI Mouse Phenotypes related to Bone Osteosarcoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.02 BCOR CDK4 MDM2 NKX3-2 SATB2
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Drugs & Therapeutics for Bone Osteosarcoma

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Drugs for Bone Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 370)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Radium Ra 223 dichloride Approved, Investigational Phase 4,Phase 1,Phase 2 444811-40-9
2
Lithium carbonate Approved Phase 4 554-13-2
3
Heparin Approved, Investigational Phase 4,Not Applicable 9005-49-6 772 46507594
4
Dalteparin Approved Phase 4,Not Applicable 9005-49-6
5
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
6
Enoxaparin Approved Phase 4 9005-49-6 772
7 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
8 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
10 Analgesics, Non-Narcotic Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
11 Antirheumatic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
12 Analgesics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Central Nervous System Depressants Phase 4,Phase 3,Phase 1
14 Cyclooxygenase Inhibitors Phase 4,Phase 2,Not Applicable
15 Antidepressive Agents Phase 4
16 Antimanic Agents Phase 4,Phase 1
17 Psychotropic Drugs Phase 4,Phase 1
18 Tranquilizing Agents Phase 4,Phase 1
19 calcium heparin Phase 4,Not Applicable
20 Fibrinolytic Agents Phase 4,Not Applicable
21 Heparin, Low-Molecular-Weight Phase 4,Not Applicable
22 Anticoagulants Phase 4,Not Applicable
23 Antipyretics Phase 4
24 Platelet Aggregation Inhibitors Phase 4
25
Doxorubicin Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 23214-92-8 31703
26
Cisplatin Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 15663-27-1 441203 84093 2767
27
Zoledronic Acid Approved Phase 2, Phase 3,Phase 3,Phase 1 118072-93-8 68740
28
Ifosfamide Approved Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable 3778-73-2 3690
29
Diphenhydramine Approved, Investigational Phase 2, Phase 3 147-24-0, 58-73-1 3100
30
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 1177-87-3
31
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 50-02-2 5743
32
Promethazine Approved, Investigational Phase 2, Phase 3 60-87-7 4927
33
Docetaxel Approved, Investigational Phase 2, Phase 3,Phase 1,Not Applicable 114977-28-5 148124
34
Gemcitabine Approved Phase 2, Phase 3,Phase 1,Not Applicable 95058-81-4 60750
35
Sargramostim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 123774-72-1, 83869-56-1
36
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 135968-09-1
37
Melphalan Approved Phase 3,Phase 2,Phase 1,Not Applicable 148-82-3 460612 4053
38
Busulfan Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 55-98-1 2478
39
Etoposide Approved Phase 3,Phase 1,Phase 2,Not Applicable 33419-42-0 36462
40
Dactinomycin Approved, Investigational Phase 3,Phase 2,Not Applicable 50-76-0 457193 2019
41
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 2068-78-2, 57-22-7 5978
42
Mesna Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 3375-50-6 598
43
Cobalt Approved, Experimental Phase 3,Phase 1,Phase 2 7440-48-4 104729
44
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 6055-19-2, 50-18-0 2907
45
Mechlorethamine Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 51-75-2 4033
46
Methotrexate Approved Phase 3,Phase 2,Phase 1,Not Applicable 1959-05-2, 59-05-2 126941
47
leucovorin Approved Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 6006 143
48
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 22916-47-8 4189
49
Sirolimus Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 53123-88-9 46835353 6436030 5284616
50
Irinotecan Approved, Investigational Phase 3,Phase 2,Phase 1 100286-90-6, 97682-44-5 60838

Interventional clinical trials:

(show top 50) (show all 476)
# Name Status NCT ID Phase Drugs
1 Clinical Trial of Lithium Carbonate Combined With Neo-adjuvant Chemotherapy to Treat Osteosarcoma Recruiting NCT01669369 Phase 4 Lithium Carbonate;Placebo
2 Radium-223 Dichloride Long-term Follow-up Program Recruiting NCT02312960 Phase 4
3 Low Molecular Weight Heparin (LMWH) vs Aspirin for Venous Thromboembolism (VTE) Prophylaxis in Orthopaedic Oncology Enrolling by invitation NCT03244020 Phase 4 Aspirin 325mg;Enoxaparin 40Mg/0.4mL Prefilled Syringe
4 Evaluation of Zoledronic Acid as a Single Agent or as an Adjuvant to Chemotherapy in High Grade Osteosarcoma Unknown status NCT00691236 Phase 2, Phase 3 Zoledronic acid;Standard chemotherapy
5 A Clinical Trial on Efficacy and Safety for Lobaplatin and Gemcitabine in Combination With Docetaxel in the Second-line Treatments on Advanced Osteosarcoma Unknown status NCT02099396 Phase 2, Phase 3 Docetaxel+lobaplatin;Gemcitabine+lobaplatin
6 Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer Unknown status NCT01987596 Phase 3
7 Study in Localized and Disseminated Ewing Sarcoma Unknown status NCT00987636 Phase 3 Zoledronic acid;Busulfan;Treosulfan
8 Combination Chemotherapy Plus Surgery and Radiation Therapy in Treating Patients With Ewing's Sarcoma Unknown status NCT00002516 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;mesna;vincristine sulfate
9 Combination Chemotherapy With or Without Peripheral Stem Cell Transplantation, Radiation Therapy, and/or Surgery in Treating Patients With Ewing's Sarcoma Unknown status NCT00020566 Phase 3 busulfan;doxorubicin hydrochloride;etoposide;ifosfamide;melphalan;vincristine sulfate
10 Apatinib for Advanced Osteosarcoma After Failure of Standard Multimodal Therapy Completed NCT02711007 Phase 2, Phase 3 apatinib
11 Comparison of High-Dose Methotrexate (HDM) Plus Doxorubicin to HDM Plus Etoposide-Ifosfamide in Osteosarcoma Children Completed NCT00180908 Phase 3 Etoposide, Ifosfamide, Methotrexate;Doxorubicin, Methotrexate
12 Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With Osteosarcoma Completed NCT01176981 Phase 3 High Dose Methotrexate
13 Osteosarcoma Study #2: A Randomized Trial of Pre-Surgical Chemotherapy vs. Immediate Surgery and Adjuvant Chemotherapy in the Treatment of Non-Metastatic Osteosarcoma. A Pediatric Oncology Group Phase III Study Completed NCT00001217 Phase 3 pre-surgical chemotherapy
14 Combination Chemotherapy and Surgery With or Without G-CSF in Treating Patients With Osteosarcoma Completed NCT00002539 Phase 3 cisplatin;doxorubicin hydrochloride
15 Combination Chemotherapy Plus Dexrazoxane in Treating Patients With Newly Diagnosed Nonmetastatic Osteosarcoma Completed NCT00003937 Phase 3 cisplatin;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate
16 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
17 Ridaforolimus in Treatment of Sarcoma-SUCCEED (Sarcoma Multi-Center Clinical Evaluation of the Efficacy of Ridaforolimus)(8669-011 AM6) Completed NCT00538239 Phase 3 ridaforolimus;Placebo
18 Observation, Radiation Therapy, Combination Chemotherapy, and/or Surgery in Treating Young Patients With Soft Tissue Sarcoma Completed NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
19 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
20 Music Therapy or Book Discussion in Improving Quality of Life in Young Patients Undergoing Stem Cell Transplant Completed NCT00305851 Phase 3
21 Combination Chemotherapy With or Without Hyperthermia Therapy in Treating Patients With Soft Tissue Sarcoma Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
22 Comparison of Combination Chemotherapy Regimens in Treating Patients With Ewing's Sarcoma or Neuroectodermal Tumor Completed NCT00006734 Phase 3 cyclophosphamide;doxorubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
23 ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma Recruiting NCT01459484 Phase 2, Phase 3 Mifamurtide arm
24 Prophylactic Antibiotic Regimens in Tumor Surgery (PARITY) Recruiting NCT01479283 Phase 3 24-Hour Prophylactic Cefazolin* Antibiotic Regimen;5-Days Prophylactic Cefazolin* Antibiotic Regimen
25 Efficacy of Dose Intensification in Patients With Non-metastatic Ewing Sarcoma Recruiting NCT02063022 Phase 3 Standard treatment (as per protocol ISG SSG III);Intensified chemotherapy
26 Vigil + Irinotecan and Temozolomide in Ewing's Sarcoma Recruiting NCT03495921 Phase 3 Irinotecan;Temozolomide
27 Combination Chemotherapy, PEG-Interferon Alfa-2b, and Surgery in Treating Patients With Osteosarcoma Active, not recruiting NCT00134030 Phase 3 Cisplatin;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Methotrexate
28 Randomized Controlled Trial to Assess Blockade of Voltage Gated Sodium Channels During Surgery in Operable Breast Cancer Active, not recruiting NCT01916317 Phase 3 0.5% lignocaine 60mM
29 Co-treatment With GnRH Analogs on the Ovarian Reserve in Young Women Treated With Alkylating Agents for Cancer Active, not recruiting NCT02856048 Phase 2, Phase 3 Triptorelin (GnRHa) + Chemotherapy
30 Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin Hydrochloride;Ifosfamide;Pazopanib Hydrochloride
31 Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma Active, not recruiting NCT02306161 Phase 3 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Vincristine Sulfate
32 Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma Active, not recruiting NCT01231906 Phase 3 Cyclophosphamide;Doxorubicin Hydrochloride;Etoposide;Ifosfamide;Topotecan Hydrochloride;Vincristine Sulfate
33 Combined Chemotherapy With or Without Zoledronic Acid for Patients With Osteosarcoma Terminated NCT00470223 Phase 3 cisplatin;doxorubicin hydrochloride;etoposide;ifosfamide;methotrexate;zoledronic acid
34 Enbrel Versus Placebo With Radiation Therapy to Combat Fatigue and Cachexia Terminated NCT00127387 Phase 2, Phase 3 Enbrel
35 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
36 Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
37 Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients Withdrawn NCT01734863 Phase 3
38 Combination Chemotherapy With or Without Topotecan in Treating Patients With Newly Diagnosed Localized Ewing's Sarcoma Withdrawn NCT00334867 Phase 3 cyclophosphamide;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;ifosfamide;topotecan hydrochloride;vincristine sulfate
39 Phase II Study of Everolimus in Children and Adolescents With Refractory or Relapsed Osteosarcoma Unknown status NCT01216826 Phase 2 Everolimus
40 A Study of Endostar Combined With Chemotherapy for Treatment of Osteosarcoma Unknown status NCT01002092 Phase 2 Chemotherapy;Endostar
41 Pilot Study of Curcumin Formulation and Ashwagandha Extract in Advanced Osteosarcoma Unknown status NCT00689195 Phase 1, Phase 2
42 Prospective Clinical Trial Evaluating Metronomic Chemotherapy in Patients With High-grade, Operable, Non-metastatic Osteosarcoma of the Extremity Unknown status NCT02273583 Phase 2 continuous oral cyclophosphamide and methotrexate
43 Pilot Study of Expanded , Activated Haploidentical Natural Killer Cell Infusions for Sarcomas Unknown status NCT02409576 Phase 1, Phase 2
44 Study of Vinorelbine and Cyclofosfamide Among Patients With Refractory Tumours or in Relapse Unknown status NCT00180947 Phase 2 Vinorelbine, cyclofosfamide
45 The Adoptive Immunotherapy for Solid Tumors Using Modified Autologous Cytokine-induced Killer Cells Unknown status NCT01868490 Phase 1, Phase 2 cytokine induced killer cells
46 Interferon Alfa and Thalidomide in Treating Patients With Soft Tissue Sarcoma or Bone Sarcoma Unknown status NCT00026416 Phase 2 thalidomide
47 Hematopoietic Stem Cell Transplantation From Human Leukocyte Antigen (HLA) Compatible Donor in Ewing Sarcomas and Soft Tissues Sarcomas Unknown status NCT00998361 Phase 2
48 Tandem Peripheral Blood Stem Cell (PBSC) Rescue for High Risk Solid Tumors Unknown status NCT00179816 Phase 1, Phase 2 High-Dose Chemotherapy with Tandem PBSC Rescue.
49 Trial With Gemcitabine and Rapamycin in Second Line of Metastatic Osteosarcoma Completed NCT02429973 Phase 2 Gemcitabine plus rapamycin
50 A Eurosarc Study of Mifamurtide in Advanced Osteosarcoma (MEMOS) Completed NCT02441309 Phase 2 Mifamurtide;Ifosfamide

Search NIH Clinical Center for Bone Osteosarcoma

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Genetic Tests for Bone Osteosarcoma

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Anatomical Context for Bone Osteosarcoma

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MalaCards organs/tissues related to Bone Osteosarcoma:

42
Bone, Lung, T Cells, Brain, Testes, Nk Cells, Bone Marrow
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Publications for Bone Osteosarcoma

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Articles related to Bone Osteosarcoma:

(show all 21)
# Title Authors Year
1
Sequence analysis of cell-free DNA derived from cultured human bone osteosarcoma (143B) cells. ( 30261820 )
2018
2
Cytotoxic effect of ferrimagnetic glass-ceramic nanocomposites on bone osteosarcoma cells. ( 28152478 )
2017
3
Orbital metastasis: a rare manifestation of scapular bone osteosarcoma. ( 25709781 )
2014
4
Expression of cyclooxygenase-2 in osteosarcoma of bone. ( 17536311 )
2007
5
Primary bone osteosarcoma in the pediatric age: state of the art. ( 16860938 )
2006
6
Ultrastructure of low-grade intraosseous osteosarcoma of bone: a comparative study with fibrous dysplasia and parosteal osteosarcoma. ( 16971354 )
2006
7
Osteosarcoma of bone in apatient with primary hyperparathyroidism: a case report. ( 12510819 )
2003
8
Endobronchial metastasis from osteosarcoma of bone: treatment with intraluminal radiotherapy. ( 10593811 )
1999
9
Osteosarcoma of bone. ( 9732564 )
1998
10
Small cell osteosarcoma of bone. Review of 72 cases. ( 9179055 )
1997
11
Treatment of a second bone osteosarcoma. 3 cases and an unusual MRI finding. ( 7976302 )
1994
12
Epithelioid osteosarcoma of bone. Immunocytochemical evidence suggesting divergent epithelial and mesenchymal differentiation in a primary osseous neoplasm. ( 7683966 )
1993
13
Small cell osteosarcoma of bone: an immunohistochemical study with differential diagnostic considerations. ( 7503935 )
1993
14
Problems and pitfalls in the use of computed tomography for the local evaluation of long bone osteosarcoma: report on 30 cases. ( 3856325 )
1985
15
Computed tomography of long-bone osteosarcoma. ( 286376 )
1979
16
Long bone osteosarcoma in a rhesus monkey. ( 293317 )
1979
17
Osteosarcoma of bone and a consideration of prognostic variables. ( 273473 )
1978
18
Osteosarcoma of bone and its important recognizable varieties. ( 203202 )
1977
19
Primary osteosarcoma of bone. Clinicopathologic investigation of 243 cases, with necropsy studies in 54. ( 266360 )
1977
20
Malignant tumors primary in bone (osteosarcoma, chondrosarcoma, fibrosarcoma, malignant giant cell tumor). ( 5272232 )
1970
21
OSTEOSARCOMA OF BONE. ( 14119114 )
1964
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Variations for Bone Osteosarcoma

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Expression for Bone Osteosarcoma

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Search GEO for disease gene expression data for Bone Osteosarcoma.
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Pathways for Bone Osteosarcoma

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Pathways related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Regulation of retinoblastoma protein 1
11 BGLAP MDM2
2
Integrated Cancer Pathway 1
10.82 CDK4 MDM2
3
DNA damage_ATM/ATR regulation of G1/S checkpoint 23
10.6 CDK4 MDM2
4
Oncogene Induced Senescence 67
10.13 CDK4 MDM2
Sources

GO Terms for Bone Osteosarcoma

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Biological processes related to Bone Osteosarcoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 9.8 BCOR MDM2 NKX3-2 SATB2
2 response to drug GO:0042493 9.69 BGLAP CDK4 MDM2
3 heart development GO:0007507 9.63 BCOR MDM2 SPARC
4 positive regulation of cell cycle GO:0045787 9.54 CDK4 MDM2
5 regulation of gene expression GO:0010468 9.54 CDK4 MDM2 SATB2
6 bone development GO:0060348 9.52 BGLAP SPARC
7 cellular response to organic substance GO:0071310 9.48 MDM2 SATB2
8 response to testosterone GO:0033574 9.43 BGLAP CDK4
9 odontogenesis GO:0042476 9.4 BCOR BGLAP
10 negative regulation of cell cycle arrest GO:0071157 9.32 CDK4 MDM2
11 response to lead ion GO:0010288 9.26 CDK4 SPARC
12 osteoblast development GO:0002076 9.16 BGLAP SATB2
13 response to gravity GO:0009629 8.96 BGLAP SPARC
14 cellular response to growth factor stimulus GO:0071363 8.8 BGLAP MDM2 SPARC
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Sources for Bone Osteosarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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