MCID: BNR001
MIFTS: 31

Bone Remodeling Disease

Categories: Bone diseases

Aliases & Classifications for Bone Remodeling Disease

MalaCards integrated aliases for Bone Remodeling Disease:

Name: Bone Remodeling Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080005

Summaries for Bone Remodeling Disease

Disease Ontology : 12 A bone disease that results in formation or resorption abnormalities located in bone.

MalaCards based summary : Bone Remodeling Disease is related to fibrous dysplasia and hyperostosis. An important gene associated with Bone Remodeling Disease is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. Affiliated tissues include bone, kidney and bone, and related phenotypes are Decreased viability and Decreased viability

Wikipedia : 76 Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the... more...

Related Diseases for Bone Remodeling Disease

Diseases related to Bone Remodeling Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 fibrous dysplasia 32.0 BGLAP CALCA FGF23
2 hyperostosis 31.8 FGF23 LRP5 SOST TNFRSF11B
3 rickets 31.8 BGLAP FGF23 PHEX PTH VDR
4 osteomalacia 31.7 BGLAP CALCA FGF23 PHEX PTH VDR
5 endosteal hyperostosis, autosomal dominant 31.6 BMP2 CLCN7 CTSK LRP5 TNFRSF11B TNFSF11
6 bone resorption disease 30.6 ACP5 BGLAP BMP2 CALCA CTSK LRP5
7 axial osteomalacia 10.3 BGLAP PTH
8 extraskeletal chondroma 10.3 BGLAP PTH
9 fibrogenesis imperfecta ossium 10.3 CALCA PTH TNFRSF11B
10 osteitis fibrosa 10.3 BGLAP CALCA PTH
11 hypophosphatasia, adult 10.3 BGLAP CALCA PTH
12 kummell's disease 10.3 SOST TNFRSF11B TNFSF11
13 multicentric reticulohistiocytosis 10.3 TNFRSF11B TNFSF11
14 pseudoarthrosis 10.3 BMP2 PTH
15 autosomal recessive malignant osteopetrosis 10.3 CLCN7 TNFSF11
16 villonodular synovitis 10.3 ACP5 TNFSF11
17 periodontitis, chronic 10.3 TNFRSF11B TNFSF11
18 bone fracture 10.3 BGLAP BMP2
19 hypercalcemia, infantile, 1 10.3 CALCA PTH VDR
20 breast leiomyosarcoma 10.3 TNFRSF11A TNFSF11
21 polyarticular onset juvenile idiopathic arthritis 10.3 TNFRSF11A TNFRSF11B TNFSF11
22 hypervitaminosis d 10.3 FGF23 PTH VDR
23 metaphyseal chondrodysplasia, jansen type 10.3 CALCA FGF23 PTH
24 calciphylaxis 10.3 FGF23 PTH VDR
25 sclerosteosis 1 10.3 SOST SP7
26 chronic apical periodontitis 10.3 TNFRSF11B TNFSF11
27 hemophilic arthropathy 10.3 TNFRSF11A TNFRSF11B TNFSF11
28 idiopathic hypercalciuria 10.3 BGLAP TNFSF11 VDR
29 oncogenic osteomalacia 10.3 FGF23 PHEX PTH
30 osteopetrosis, autosomal recessive 7 10.3 TNFRSF11A TNFSF11
31 familial expansile osteolysis 10.3 TNFRSF11A TNFRSF11B TNFSF11
32 tooth ankylosis 10.3 BMP2 TNFSF11
33 hypophosphatemic rickets, x-linked dominant 10.3 FGF23 PHEX PTH
34 aneurysmal bone cysts 10.3 CALCA TNFRSF11A TNFSF11
35 hypoparathyroidism 10.3 BGLAP FGF23 PTH
36 osteogenesis imperfecta, type i 10.3 BGLAP PHEX TNFRSF11B
37 ossification of the posterior longitudinal ligament of spine 10.2 BGLAP BMP2 RUNX2
38 hypophosphatemic rickets with hypercalciuria, hereditary 10.2 FGF23 PHEX PTH
39 impaired renal function disease 10.2 BGLAP FGF23 PTH SOST
40 uremia 10.2 PTH TNFRSF11B VDR
41 craniodiaphyseal dysplasia 10.2 CALCA LRP5 SOST
42 osseous heteroplasia, progressive 10.2 BGLAP BMP2 RUNX2
43 vitamin d-dependent rickets, type 2a 10.2 PHEX VDR
44 camurati-engelmann disease 10.2 ACP5 BGLAP LRP5
45 parathyroid adenoma 10.2 BGLAP CALCA PTH VDR
46 calcinosis 10.2 CALCA FGF23 PHEX
47 bone giant cell tumor 10.2 ACP5 CALCA CTSK TNFSF11
48 opsismodysplasia 10.2 FGF23 PHEX
49 hypophosphatemic rickets, x-linked recessive 10.2 FGF23 PHEX VDR
50 paget disease of bone 5, juvenile-onset 10.2 CALCA TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Bone Remodeling Disease:



Diseases related to Bone Remodeling Disease

Symptoms & Phenotypes for Bone Remodeling Disease

GenomeRNAi Phenotypes related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.1 TNFRSF11B
2 Decreased viability GR00221-A-2 10.1 TNFRSF11B
3 Decreased viability GR00221-A-3 10.1 EXT1
4 Decreased viability GR00240-S-1 10.1 SP7 TNFRSF11A
5 Decreased viability GR00381-A-1 10.1 CALCA CTSK RPL24
6 Decreased viability GR00402-S-2 10.1 ACP5 BGLAP BMP2 CALCA CLCN7 CTSK
7 no effect GR00402-S-1 9.62 ACP5 BGLAP BMP2 CALCA CLCN7 CTSK

MGI Mouse Phenotypes related to Bone Remodeling Disease:

46 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 BMP2 CLCN7 CTSK EXT1 LRP5 NFATC1
2 growth/size/body region MP:0005378 10.36 BMP2 CLCN7 CTSK EXT1 FGF23 LRP5
3 craniofacial MP:0005382 10.32 BMP2 CLCN7 CTSK EXT1 LRP5 NFATC1
4 hematopoietic system MP:0005397 10.25 BMP2 CLCN7 CTSK FGF23 LRP5 NFATC1
5 homeostasis/metabolism MP:0005376 10.25 BMP2 CLCN7 CTSK FGF23 LRP5 NFATC1
6 cardiovascular system MP:0005385 10.24 BMP2 FGF23 LRP5 NFATC1 PHEX PTH
7 immune system MP:0005387 10.21 BMP2 CLCN7 CTSK FGF23 LRP5 NFATC1
8 limbs/digits/tail MP:0005371 10.19 BMP2 CLCN7 CTSK EXT1 FGF23 LRP5
9 digestive/alimentary MP:0005381 10.15 BMP2 CTSK EXT1 FGF23 NFATC1 PHEX
10 endocrine/exocrine gland MP:0005379 10.13 CTSK FGF23 LRP5 PHEX PTH RUNX2
11 mortality/aging MP:0010768 10.03 BMP2 CLCN7 EXT1 FGF23 LRP5 NFATC1
12 integument MP:0010771 9.97 CLCN7 EXT1 FGF23 NFATC1 RPL24 RUNX2
13 respiratory system MP:0005388 9.56 CLCN7 CTSK FGF23 NFATC1 RUNX2 SP7
14 skeleton MP:0005390 9.55 BMP2 CLCN7 CTSK EXT1 FGF23 LRP5

Drugs & Therapeutics for Bone Remodeling Disease

Search Clinical Trials , NIH Clinical Center for Bone Remodeling Disease

Genetic Tests for Bone Remodeling Disease

Anatomical Context for Bone Remodeling Disease

MalaCards organs/tissues related to Bone Remodeling Disease:

41
Bone, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Remodeling Disease:

19
Bone

Publications for Bone Remodeling Disease

Variations for Bone Remodeling Disease

Expression for Bone Remodeling Disease

Search GEO for disease gene expression data for Bone Remodeling Disease.

Pathways for Bone Remodeling Disease

GO Terms for Bone Remodeling Disease

Cellular components related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 BGLAP BMP2 CALCA CTSK FGF23 PTH
2 extracellular space GO:0005615 9.28 BGLAP BMP2 CALCA CTSK FGF23 PTH

Biological processes related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.95 BMP2 CALCA FGF23 PTH TNFRSF11B TNFSF11
2 cell-cell signaling GO:0007267 9.85 BMP2 CALCA PHEX PTH TNFRSF11A
3 animal organ morphogenesis GO:0009887 9.84 BMP2 TNFSF11 VDR
4 osteoblast differentiation GO:0001649 9.84 BGLAP BMP2 RUNX2 SP7
5 cellular calcium ion homeostasis GO:0006874 9.83 CALCA PTH VDR
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 TNFRSF11A TNFRSF11B TNFSF11
7 positive regulation of osteoblast differentiation GO:0045669 9.79 BMP2 LRP5 RUNX2
8 bone development GO:0060348 9.77 BGLAP PHEX TNFSF11
9 monocyte chemotaxis GO:0002548 9.75 CALCA TNFRSF11A TNFSF11
10 positive regulation of bone resorption GO:0045780 9.66 TNFRSF11A TNFSF11
11 mammary gland alveolus development GO:0060749 9.66 TNFRSF11A TNFSF11
12 regulation of osteoclast differentiation GO:0045670 9.65 BGLAP TNFSF11
13 positive regulation of ossification GO:0045778 9.65 BMP2 PTH
14 negative regulation of bone resorption GO:0045779 9.64 CALCA TNFRSF11B
15 response to inorganic substance GO:0010035 9.64 BGLAP TNFRSF11B
16 response to magnesium ion GO:0032026 9.63 FGF23 TNFRSF11B
17 vitamin D metabolic process GO:0042359 9.63 FGF23 VDR
18 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.62 BMP2 RUNX2
19 phosphate ion homeostasis GO:0055062 9.61 FGF23 PTH
20 response to vitamin D GO:0033280 9.61 BGLAP PHEX PTH
21 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.59 BMP2 RUNX2
22 osteoblast development GO:0002076 9.58 BGLAP LRP5 RUNX2
23 TNFSF11-mediated signaling pathway GO:0071847 9.57 TNFRSF11A TNFSF11
24 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.56 FGF23 VDR
25 bone mineralization GO:0030282 9.56 BGLAP BMP2 PHEX PTH
26 skeletal system development GO:0001501 9.56 BGLAP BMP2 EXT1 PHEX PTH RUNX2
27 response to sodium phosphate GO:1904383 9.55 FGF23 PHEX
28 cellular response to vitamin D GO:0071305 9.54 BGLAP FGF23 PHEX
29 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.52 TNFRSF11A TNFSF11
30 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.51 TNFRSF11A TNFSF11
31 cellular response to parathyroid hormone stimulus GO:0071374 9.5 FGF23 PHEX SOST
32 bone resorption GO:0045453 9.46 ACP5 CTSK PTH TNFSF11
33 ossification GO:0001503 9.23 ACP5 BGLAP BMP2 EXT1 RUNX2 SOST
34 positive regulation of transcription by RNA polymerase II GO:0045944 10.1 BMP2 LRP5 NFATC1 PTH RUNX2 SP7
35 positive regulation of transcription, DNA-templated GO:0045893 10.06 BMP2 FGF23 LRP5 NFATC1 RUNX2 SOST

Sources for Bone Remodeling Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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