Bone Remodeling Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BNR001 MIFTS: 29	Bone Remodeling Disease Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Bone Remodeling Disease

MalaCards integrated aliases for Bone Remodeling Disease:

Name: Bone Remodeling Disease ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080005

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Summaries for Bone Remodeling Disease

Disease Ontology : ¹² A bone disease that results in formation or resorption abnormalities located in bone.

MalaCards based summary : Bone Remodeling Disease is related to hyperostosis and fibrous dysplasia. An important gene associated with Bone Remodeling Disease is PTH (Parathyroid Hormone), and among its related pathways/superpathways are MicroRNAs in cancer and Rheumatoid arthritis. Affiliated tissues include bone, kidney and breast, and related phenotypes are craniofacial and limbs/digits/tail

Wikipedia : ⁷³ Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the... more...

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Related Diseases for Bone Remodeling Disease

Diseases related to Bone Remodeling Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)

#	Related Disease	Score	Top Affiliating Genes
1	hyperostosis	32.5	SOST LRP5 FGF23
2	fibrous dysplasia	32.4	TNFSF11 FGF23 CALCA BGLAP
3	rickets	32.4	PTH PHEX FGF23 BGLAP
4	osteomalacia	32.4	PTH PHEX FGF23 CALCA BGLAP
5	endosteal hyperostosis, autosomal dominant	32.1	TNFSF11 SP7 SOST PTH PHEX NFATC1
6	bone resorption disease	31.7	TNFSF11 SP7 SOST RUNX2 PTH NFATC1
7	familial expansile osteolysis	11.1
8	malignant ovarian brenner tumor	10.6	TNFSF11 PTH CALCA
9	gorham's disease	10.6	TNFSF11 PTH CALCA
10	kummell's disease	10.6	TNFSF11 SOST CALCA
11	substernal goiter	10.6	PTH CALCA
12	hypervitaminosis d	10.6	PTH FGF23 CALCA
13	nontoxic goiter	10.6	PTH CALCA BGLAP
14	giant cell reparative granuloma	10.6	TNFSF11 PTH CALCA
15	osteopetrosis, autosomal dominant 2	10.6	TNFSF11 BGLAP ACP5
16	chondrodysplasia, blomstrand type	10.6	TNFSF11 PTH BGLAP
17	vitamin d-dependent rickets	10.6	PTH PHEX BGLAP
18	oncogenic osteomalacia	10.6	PTH PHEX FGF23
19	dental abscess	10.5	PTH PHEX FGF23
20	osteitis fibrosa	10.5	PTH FGF23 CALCA BGLAP
21	dental pulp necrosis	10.5	TNFSF11 BMP2 BGLAP
22	hypophosphatemic rickets with hypercalciuria, hereditary	10.5	PTH PHEX FGF23
23	multicentric carpotarsal osteolysis syndrome	10.5	TNFSF11 CTSK BGLAP ACP5
24	periapical periodontitis	10.5	TNFSF11 RUNX2 CTSK ACP5
25	pycnodysostosis	10.5	TNFSF11 SOST CTSK ACP5
26	ossification of the posterior longitudinal ligament of spine	10.5	RUNX2 BMP2 BGLAP
27	enthesopathy	10.5	PTH PHEX FGF23
28	enchondromatosis, multiple, ollier type	10.5	RUNX2 PTH ACP5
29	metaphyseal chondrodysplasia, jansen type	10.5	PTH PHEX FGF23
30	hypocalcemia, autosomal dominant 1	10.5	PTH FGF23 CALCA BGLAP
31	root resorption	10.5	TNFSF11 RUNX2 CTSK CALCA
32	dental pulp disease	10.5	RUNX2 BMP2 BGLAP
33	autosomal recessive hypophosphatemic rickets	10.5	SOST PTH PHEX FGF23
34	hypophosphatemic rickets, autosomal dominant	10.5	PTH PHEX FGF23
35	bone osteosarcoma	10.5	TNFSF11 RUNX2 MIR133A1 BGLAP
36	osteopetrosis, autosomal recessive 2	10.5	TNFSF11 NFATC1 CTSK ACP5
37	teeth hard tissue disease	10.5	TNFSF11 BGLAP ACP5
38	osteopetrosis, autosomal recessive 8	10.5	TNFSF11 NFATC1 CTSK ACP5
39	osseous heteroplasia, progressive	10.5	RUNX2 PTH BMP2 BGLAP
40	pseudohypoparathyroidism	10.5	PTH CALCA BGLAP
41	sclerosteosis 1	10.5	SP7 SOST LRP5 BGLAP
42	exostosis	10.5	SOST CALCA BMP2 BGLAP
43	bone giant cell tumor	10.5	TNFSF11 PTH CTSK CALCA ACP5
44	tumoral calcinosis, hyperphosphatemic, familial, 1	10.5	PTH PHEX FGF23
45	cherubism	10.5	TNFSF11 NFATC1 CALCA
46	hyperthyroidism	10.5	PTH CALCA BGLAP ACP5
47	osteoporosis-pseudoglioma syndrome	10.5	SOST RUNX2 LRP5
48	hypoparathyroidism	10.5	PTH FGF23 CALCA BGLAP
49	hypophosphatemia	10.5	PTH PHEX FGF23 BGLAP
50	benign giant cell tumor	10.5	TNFSF11 FGF23 CTSK CALCA BGLAP

Graphical network of the top 20 diseases related to Bone Remodeling Disease:

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Symptoms & Phenotypes for Bone Remodeling Disease

MGI Mouse Phenotypes related to Bone Remodeling Disease:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	9.76	BMP2 CTSK LRP5 NFATC1 PHEX PTH
2	limbs/digits/tail	MP:0005371	9.7	BMP2 CTSK FGF23 LRP5 NFATC1 PHEX
3	skeleton	MP:0005390	9.4	BGLAP BMP2 CTSK FGF23 LRP5 NFATC1

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Drugs & Therapeutics for Bone Remodeling Disease

Search Clinical Trials , NIH Clinical Center for Bone Remodeling Disease

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Genetic Tests for Bone Remodeling Disease

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Anatomical Context for Bone Remodeling Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Remodeling Disease:

¹⁹

Bone

MalaCards organs/tissues related to Bone Remodeling Disease:

⁴⁰

Bone, Kidney, Breast

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Publications for Bone Remodeling Disease

Articles related to Bone Remodeling Disease:

#	Title	Authors	PMID	Year
1	Peripheral Blood Mononuclear Cells Spontaneous Osteoclastogenesis: Mechanisms Driving the Process and Clinical Relevance in Skeletal Disease. ⁶¹	Salamanna F...Fini M	26284737	2016
2	Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature. ⁶¹	Anic B...Cerovec M	25230058	2014
3	Central control of bone formation. ⁶¹	Takeda S...Karsenty G	11368306	2001
4	Chronic familial hyperphosphatasemia. ⁶¹	Iancu TC...Front D	725042	1978

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Genes for Bone Remodeling Disease

Genes related to Bone Remodeling Disease (0 elite genes):

(show top 50) (show all 66)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTH	Parathyroid Hormone	Protein Coding	10.32	DISEASES inferred ¹⁵
2	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	10.26	DISEASES inferred ¹⁵
3	TNFSF11	TNF Superfamily Member 11	Protein Coding	10.2	DISEASES inferred ¹⁵
4	MIR188	MicroRNA 188	RNA Gene	9.7	DISEASES inferred ¹⁵ ¹⁵
5	SOST	Sclerostin	Protein Coding	9.52	DISEASES inferred ¹⁵
6	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	9.47	DISEASES inferred ¹⁵
7	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	9.39	DISEASES inferred ¹⁵
8	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	9.34	DISEASES inferred ¹⁵
9	CTSK	Cathepsin K	Protein Coding	9.25	DISEASES inferred ¹⁵
10	FGF23	Fibroblast Growth Factor 23	Protein Coding	9.2	DISEASES inferred ¹⁵
11	MIR133A1	MicroRNA 133a-1	RNA Gene	9.17	DISEASES inferred ¹⁵ ¹⁵
12	MIR214	MicroRNA 214	RNA Gene	9.13	DISEASES inferred ¹⁵ ¹⁵
13	MIR335	MicroRNA 335	RNA Gene	8.98	DISEASES inferred ¹⁵ ¹⁵
14	MIR23A	MicroRNA 23a	RNA Gene	8.92	DISEASES inferred ¹⁵ ¹⁵
15	PHEX	Phosphate Regulating Endopeptidase Homolog X-Linked	Protein Coding	8.87	DISEASES inferred ¹⁵
16	SP7	Sp7 Transcription Factor	Protein Coding	8.86	DISEASES inferred ¹⁵
17	MIR140	MicroRNA 140	RNA Gene	8.82	DISEASES inferred ¹⁵ ¹⁵
18	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	8.78	DISEASES inferred ¹⁵
19	LRP5	LDL Receptor Related Protein 5	Protein Coding	8.68	DISEASES inferred ¹⁵
20	BMP2	Bone Morphogenetic Protein 2	Protein Coding	8.67	DISEASES inferred ¹⁵
21	ESR1	Estrogen Receptor 1	Protein Coding	8.43	DISEASES inferred ¹⁵
22	SERPINA3	Serpin Family A Member 3	Protein Coding	8.42	DISEASES inferred ¹⁵ ¹⁵
23	IGF1	Insulin Like Growth Factor 1	Protein Coding	8.42	DISEASES inferred ¹⁵
24	SPP1	Secreted Phosphoprotein 1	Protein Coding	8.36	DISEASES inferred ¹⁵
25	IL6	Interleukin 6	Protein Coding	8.36	DISEASES inferred ¹⁵
26	H2AC18	H2A Clustered Histone 18	Protein Coding	8.33	DISEASES inferred ¹⁵ ¹⁵
27	CLCN7	Chloride Voltage-Gated Channel 7	Protein Coding	8.32	DISEASES inferred ¹⁵
28	VDR	Vitamin D Receptor	Protein Coding	8.29	DISEASES inferred ¹⁵
29	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	8.22	DISEASES inferred ¹⁵
30	IBSP	Integrin Binding Sialoprotein	Protein Coding	8.2	DISEASES inferred ¹⁵
31	DKK1	Dickkopf WNT Signaling Pathway Inhibitor 1	Protein Coding	8.18	DISEASES inferred ¹⁵
32	TNF	Tumor Necrosis Factor	Protein Coding	8.16	DISEASES inferred ¹⁵
33	MIR550A1	MicroRNA 550a-1	RNA Gene	8.15	DISEASES inferred ¹⁵ ¹⁵
34	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	8.13	DISEASES inferred ¹⁵ ¹⁵
35	CTNNB1	Catenin Beta 1	Protein Coding	8.07	DISEASES inferred ¹⁵
36	TCIRG1	T Cell Immune Regulator 1, ATPase H+ Transporting V0 Subunit A3	Protein Coding	8.04	DISEASES inferred ¹⁵
37	DCSTAMP	Dendrocyte Expressed Seven Transmembrane Protein	Protein Coding	8.01	DISEASES inferred ¹⁵
38	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	8	DISEASES inferred ¹⁵
39	FDPS	Farnesyl Diphosphate Synthase	Protein Coding	7.98	DISEASES inferred ¹⁵
40	KL	Klotho	Protein Coding	7.98	DISEASES inferred ¹⁵
41	MIR93	MicroRNA 93	RNA Gene	7.93	DISEASES inferred ¹⁵ ¹⁵
42	MEPE	Matrix Extracellular Phosphoglycoprotein	Protein Coding	7.93	DISEASES inferred ¹⁵
43	INS	Insulin	Protein Coding	7.93	DISEASES inferred ¹⁵
44	CYP27B1	Cytochrome P450 Family 27 Subfamily B Member 1	Protein Coding	7.91	DISEASES inferred ¹⁵
45	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	7.87	DISEASES inferred ¹⁵
46	MIR122	MicroRNA 122	RNA Gene	7.86	DISEASES inferred ¹⁵ ¹⁵
47	MIR199A1	MicroRNA 199a-1	RNA Gene	7.86	DISEASES inferred ¹⁵ ¹⁵
48	EXT2	Exostosin Glycosyltransferase 2	Protein Coding	7.86	DISEASES inferred ¹⁵
49	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	7.85	DISEASES inferred ¹⁵
50	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	7.85	DISEASES inferred ¹⁵

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Variations for Bone Remodeling Disease

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Expression for Bone Remodeling Disease

Search GEO for disease gene expression data for Bone Remodeling Disease.

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Pathways for Bone Remodeling Disease

Pathways related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	MicroRNAs in cancer ³⁶	12.25	MIR335 MIR23A MIR214 MIR133A1
2	Rheumatoid arthritis ³⁶	11.67	TNFSF11 PTH CTSK ACP5
3	Mesenchymal Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.63	SP7 RUNX2 PTH BMP2 BGLAP
4	FGF signaling pathway ¹	11.28	RUNX2 FGF23 BGLAP
5	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²³	11.21	TNFSF11 RUNX2 PTH BGLAP
6	Parathyroid hormone synthesis, secretion and action ³⁶	11.19	TNFSF11 SOST RUNX2 PTH LRP5 FGF23
7	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	11.01	TNFSF11 RUNX2 PTH CALCA BGLAP
8	Osteoclast Signaling ¹	10.75	TNFSF11 CTSK ACP5
9	Osteoblast Signaling ¹	10.6	TNFSF11 PTH FGF23 BGLAP

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GO Terms for Bone Remodeling Disease

Cellular components related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.4	TNFSF11 SOST PTH MIR335 MIR23A MIR140

Biological processes related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

(show all 25)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of transcription by RNA polymerase II	GO:0045944	10.12	TNFSF11 SP7 RUNX2 PTH NFATC1 LRP5
2	positive regulation of transcription, DNA-templated	GO:0045893	10.03	SOST RUNX2 NFATC1 LRP5 FGF23 BMP2
3	gene silencing by miRNA	GO:0035195	9.99	MIR335 MIR23A MIR214 MIR188 MIR140 MIR133A1
4	positive regulation of gene expression	GO:0010628	9.95	TNFSF11 RUNX2 MIR140 MIR133A1 FGF23 BMP2
5	negative regulation of gene expression	GO:0010629	9.92	PTH MIR214 MIR140 BMP2
6	cell-cell signaling	GO:0007267	9.9	PTH PHEX CALCA BMP2
7	positive regulation of osteoblast differentiation	GO:0045669	9.77	RUNX2 LRP5 BMP2
8	osteoblast differentiation	GO:0001649	9.76	SP7 RUNX2 BMP2 BGLAP
9	bone mineralization	GO:0030282	9.71	PHEX BMP2 BGLAP
10	negative regulation of vascular smooth muscle cell proliferation	GO:1904706	9.7	MIR214 MIR140 MIR133A1
11	skeletal system development	GO:0001501	9.65	RUNX2 PTH PHEX BMP2 BGLAP
12	positive regulation of ossification	GO:0045778	9.62	PTH BMP2
13	bone development	GO:0060348	9.62	TNFSF11 PHEX LRP5 BGLAP
14	regulation of osteoclast differentiation	GO:0045670	9.61	TNFSF11 BGLAP
15	positive regulation of osteoblast proliferation	GO:0033690	9.61	LRP5 BMP2
16	response to vitamin D	GO:0033280	9.61	PTH PHEX BGLAP
17	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO:1901522	9.58	RUNX2 BMP2
18	osteoblast development	GO:0002076	9.58	RUNX2 LRP5 BGLAP
19	phosphate ion homeostasis	GO:0055062	9.57	PTH FGF23
20	regulation of odontogenesis of dentin-containing tooth	GO:0042487	9.55	RUNX2 BMP2
21	cellular response to vitamin D	GO:0071305	9.54	PHEX FGF23 BGLAP
22	response to sodium phosphate	GO:1904383	9.49	PHEX FGF23
23	cellular response to parathyroid hormone stimulus	GO:0071374	9.33	SOST PHEX FGF23
24	bone resorption	GO:0045453	9.26	TNFSF11 PTH CTSK ACP5
25	ossification	GO:0001503	9.1	TNFSF11 SOST RUNX2 BMP2 BGLAP ACP5

Molecular functions related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA binding involved in posttranscriptional gene silencing	GO:1903231	9.02	MIR23A MIR214 MIR188 MIR140 MIR133A1

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Sources for Bone Remodeling Disease

¹ BioSystems

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²⁵ GeneReviews

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²⁷ GEO DataSets

²⁸ GO

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³² ICD10

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

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⁶¹ PubMed

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⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia