Bone Remodeling Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BNR001 MIFTS: 31	Bone Remodeling Disease Categories: Bone diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Bone Remodeling Disease

MalaCards integrated aliases for Bone Remodeling Disease:

Name: Bone Remodeling Disease ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080005

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Summaries for Bone Remodeling Disease

Disease Ontology : ¹² A bone disease that results in formation or resorption abnormalities located in bone.

MalaCards based summary : Bone Remodeling Disease is related to fibrous dysplasia and rickets. An important gene associated with Bone Remodeling Disease is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. Affiliated tissues include bone and bone, and related phenotypes are no effect and cellular

Wikipedia : ⁷⁷ Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the... more...

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Related Diseases for Bone Remodeling Disease

Diseases related to Bone Remodeling Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)

#	Related Disease	Score	Top Affiliating Genes
1	fibrous dysplasia	32.0	BGLAP CALCA FGF23 IGF1
2	rickets	32.0	BGLAP FGF23 PHEX PTH VDR
3	osteomalacia	31.9	BGLAP CALCA FGF23 PHEX PTH VDR
4	hyperostosis	31.9	FGF23 IGF1 LRP5 SOST TNFRSF11B
5	endosteal hyperostosis, autosomal dominant	31.7	LRP5 CTSK CLCN7 BMP2 TNFRSF11B TNFSF11
6	bone resorption disease	29.9	VDR TNFSF11 TNFRSF11B TNFRSF11A SP7 SOST
7	axial osteomalacia	10.5	BGLAP PTH
8	extraskeletal chondroma	10.5	BGLAP PTH
9	fibrogenesis imperfecta ossium	10.5	CALCA PTH TNFRSF11B
10	osteitis fibrosa	10.5	BGLAP CALCA PTH
11	kummell's disease	10.5	SOST TNFRSF11B TNFSF11
12	hypophosphatasia, adult	10.5	BGLAP CALCA PTH
13	multicentric reticulohistiocytosis	10.5	TNFRSF11B TNFSF11
14	pseudoarthrosis	10.4	BMP2 PTH
15	autosomal recessive malignant osteopetrosis	10.4	CLCN7 TNFSF11
16	hypercalcemia, infantile, 1	10.4	CALCA PTH VDR
17	villonodular synovitis	10.4	ACP5 TNFSF11
18	periodontitis, chronic	10.4	TNFRSF11B TNFSF11
19	polyarticular onset juvenile idiopathic arthritis	10.4	TNFRSF11A TNFRSF11B TNFSF11
20	bone fracture	10.4	BGLAP BMP2
21	hypervitaminosis d	10.4	FGF23 PTH VDR
22	sclerosteosis 1	10.4	SOST SP7
23	metaphyseal chondrodysplasia, jansen type	10.4	CALCA FGF23 PTH
24	calciphylaxis	10.4	FGF23 PTH VDR
25	hemophilic arthropathy	10.4	TNFRSF11A TNFRSF11B TNFSF11
26	idiopathic hypercalciuria	10.4	BGLAP TNFSF11 VDR
27	oncogenic osteomalacia	10.4	FGF23 PHEX PTH
28	osteopetrosis, autosomal recessive 7	10.4	TNFRSF11A TNFSF11
29	familial expansile osteolysis	10.4	TNFRSF11A TNFRSF11B TNFSF11
30	hypophosphatemic rickets, x-linked dominant	10.4	FGF23 PHEX PTH
31	chronic apical periodontitis	10.4	TNFRSF11B TNFSF11
32	tooth ankylosis	10.4	BMP2 TNFSF11
33	breast leiomyosarcoma	10.4	TNFRSF11A TNFSF11
34	aneurysmal bone cysts	10.4	CALCA TNFRSF11A TNFSF11
35	hypoparathyroidism	10.4	BGLAP FGF23 PTH
36	craniodiaphyseal dysplasia	10.4	CALCA LRP5 SOST
37	hypophosphatemic rickets with hypercalciuria, hereditary	10.4	FGF23 PHEX PTH
38	impaired renal function disease	10.4	BGLAP FGF23 PTH SOST
39	camurati-engelmann disease	10.4	ACP5 BGLAP LRP5
40	ossification of the posterior longitudinal ligament of spine	10.4	BGLAP BMP2 RUNX2
41	uremia	10.4	PTH TNFRSF11B VDR
42	osseous heteroplasia, progressive	10.4	BGLAP BMP2 RUNX2
43	bone giant cell tumor	10.4	ACP5 CALCA CTSK TNFSF11
44	parathyroid adenoma	10.4	BGLAP CALCA PTH VDR
45	calcinosis	10.4	CALCA FGF23 PHEX
46	vitamin d-dependent rickets, type 2a	10.4	PHEX VDR
47	hypophosphatemic rickets, x-linked recessive	10.4	FGF23 PHEX VDR
48	van buchem disease	10.4	LRP5 SOST VDR
49	endocrine organ benign neoplasm	10.4	CALCA IGF1 PTH
50	paget disease of bone 5, juvenile-onset	10.4	CALCA TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Bone Remodeling Disease:

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Symptoms & Phenotypes for Bone Remodeling Disease

GenomeRNAi Phenotypes related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	9.92	ACP5 BGLAP BMP2 CALCA CLCN7 CTSK

MGI Mouse Phenotypes related to Bone Remodeling Disease:

⁴⁷ (show all 14)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular	MP:0005384	10.4	BMP2 CLCN7 CTSK IGF1 LRP5 NFATC1
2	growth/size/body region	MP:0005378	10.36	BMP2 CLCN7 CTSK FGF23 IGF1 LRP5
3	craniofacial	MP:0005382	10.29	BMP2 CLCN7 CTSK LRP5 NFATC1 PHEX
4	cardiovascular system	MP:0005385	10.28	BMP2 FGF23 IGF1 LRP5 NFATC1 PHEX
5	hematopoietic system	MP:0005397	10.28	BMP2 CLCN7 CTSK FGF23 IGF1 LRP5
6	homeostasis/metabolism	MP:0005376	10.28	BMP2 CLCN7 CTSK FGF23 IGF1 LRP5
7	immune system	MP:0005387	10.24	BMP2 CLCN7 CTSK FGF23 IGF1 LRP5
8	limbs/digits/tail	MP:0005371	10.19	BMP2 CLCN7 CTSK FGF23 IGF1 LRP5
9	endocrine/exocrine gland	MP:0005379	10.18	CTSK FGF23 IGF1 LRP5 PHEX PTH
10	digestive/alimentary	MP:0005381	10.1	BMP2 CTSK FGF23 NFATC1 PHEX RUNX2
11	mortality/aging	MP:0010768	10.03	BMP2 CLCN7 FGF23 IGF1 LRP5 NFATC1
12	integument	MP:0010771	9.97	CLCN7 FGF23 IGF1 NFATC1 RPL24 RUNX2
13	respiratory system	MP:0005388	9.61	CLCN7 CTSK FGF23 IGF1 NFATC1 RUNX2
14	skeleton	MP:0005390	9.55	BMP2 CLCN7 CTSK FGF23 IGF1 LRP5

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Drugs & Therapeutics for Bone Remodeling Disease

Search Clinical Trials , NIH Clinical Center for Bone Remodeling Disease

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Genetic Tests for Bone Remodeling Disease

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Anatomical Context for Bone Remodeling Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Remodeling Disease:

²⁰

Bone

MalaCards organs/tissues related to Bone Remodeling Disease:

⁴²

Bone

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Publications for Bone Remodeling Disease

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Genes for Bone Remodeling Disease

Genes related to Bone Remodeling Disease (0 elite genes):

(show all 30)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	20.04	DISEASES inferred ¹⁵
2	PTH	Parathyroid Hormone	Protein Coding	19.96	DISEASES inferred ¹⁵
3	TNFSF11	TNF Superfamily Member 11	Protein Coding	19.65	DISEASES inferred ¹⁵
4	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	19.08	DISEASES inferred ¹⁵
5	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	18.93	DISEASES inferred ¹⁵
6	SOST	Sclerostin	Protein Coding	18.92	DISEASES inferred ¹⁵
7	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	18.86	DISEASES inferred ¹⁵
8	CTSK	Cathepsin K	Protein Coding	18.73	DISEASES inferred ¹⁵
9	FGF23	Fibroblast Growth Factor 23	Protein Coding	18.72	DISEASES inferred ¹⁵
10	RUNX2	Runt Related Transcription Factor 2	Protein Coding	18.62	DISEASES inferred ¹⁵
11	VDR	Vitamin D Receptor	Protein Coding	18.4	DISEASES inferred ¹⁵
12	PHEX	Phosphate Regulating Endopeptidase Homolog X-Linked	Protein Coding	18.26	DISEASES inferred ¹⁵
13	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	18.1	DISEASES inferred ¹⁵
14	SP7	Sp7 Transcription Factor	Protein Coding	18	DISEASES inferred ¹⁵
15	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	17.97	DISEASES inferred ¹⁵
16	LRP5	LDL Receptor Related Protein 5	Protein Coding	17.96	DISEASES inferred ¹⁵
17	BMP2	Bone Morphogenetic Protein 2	Protein Coding	17.93	DISEASES inferred ¹⁵
18	CLCN7	Chloride Voltage-Gated Channel 7	Protein Coding	17.85	DISEASES inferred ¹⁵
19	IGF1	Insulin Like Growth Factor 1	Protein Coding	17.54	DISEASES inferred ¹⁵
20	RPL24	Ribosomal Protein L24	Protein Coding	7.61	DISEASES inferred ¹⁵
21	EXT1	Exostosin Glycosyltransferase 1	Protein Coding	7.5	DISEASES inferred ¹⁵
22	EXT2	Exostosin Glycosyltransferase 2	Protein Coding	7.49	DISEASES inferred ¹⁵
23	TCIRG1	T Cell Immune Regulator 1, ATPase H+ Transporting V0 Subunit A3	Protein Coding	7.43	DISEASES inferred ¹⁵
24	ESR1	Estrogen Receptor 1	Protein Coding	7.35	DISEASES inferred ¹⁵
25	CYP27A1	Cytochrome P450 Family 27 Subfamily A Member 1	Protein Coding	7.32	DISEASES inferred ¹⁵
26	ZNF592	Zinc Finger Protein 592	Protein Coding	7.32	DISEASES inferred ¹⁵
27	SLC51A	Solute Carrier Family 51 Alpha Subunit	Protein Coding	7.28	DISEASES inferred ¹⁵
28	COL1A2	Collagen Type I Alpha 2 Chain	Protein Coding	7.23	DISEASES inferred ¹⁵
29	MEPE	Matrix Extracellular Phosphoglycoprotein	Protein Coding	7.21	DISEASES inferred ¹⁵
30	SLC34A3	Solute Carrier Family 34 Member 3	Protein Coding	7.18	DISEASES inferred ¹⁵

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Variations for Bone Remodeling Disease

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Expression for Bone Remodeling Disease

Search GEO for disease gene expression data for Bone Remodeling Disease.

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Pathways for Bone Remodeling Disease

Pathways related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

(show all 11)

#	Super pathways	Score	Top Affiliating Genes
1	RANK Signaling in Osteoclasts ⁶⁵ Show member pathways Apoptosis and survival APRIL and BAFF signaling ²³ APRIL Pathway ⁶⁵ BAFF in B-Cell Signaling ⁶⁵ RANK Pathway ⁶⁵ RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway ¹	12.28	ACP5 CTSK NFATC1 TNFRSF11A TNFRSF11B TNFSF11
2	Osteoclast differentiation ³⁸	11.95	ACP5 CTSK NFATC1 TNFRSF11A TNFRSF11B TNFSF11
3	Rheumatoid arthritis ³⁸	11.69	ACP5 CTSK TNFRSF11A TNFSF11
4	Parathyroid hormone synthesis, secretion and action ³⁸	11.58	BGLAP FGF23 LRP5 PTH RUNX2 SOST
5	Endochondral Ossification ¹	11.47	IGF1 PTH RUNX2
6	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²³	11.31	BGLAP PTH RUNX2 TNFSF11 VDR
7	FGF signaling pathway ¹	11.3	BGLAP FGF23 RUNX2
8	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	10.93	BGLAP CALCA IGF1 PTH RUNX2 TNFRSF11A
9	Osteoclast Signaling ¹	10.86	ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
10	Osteoblast Signaling ¹	10.7	BGLAP FGF23 PTH TNFRSF11B TNFSF11
11	Vitamin D Metabolism ¹	10.49	PTH VDR

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GO Terms for Bone Remodeling Disease

Cellular components related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.65	BGLAP BMP2 CALCA CTSK FGF23 IGF1
2	extracellular space	GO:0005615	9.32	BGLAP BMP2 CALCA CTSK FGF23 IGF1

Biological processes related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

(show all 38)

#	Name	GO ID	Score	Top Affiliating Genes
1	cell-cell signaling	GO:0007267	9.92	BMP2 CALCA PHEX PTH TNFRSF11A
2	regulation of signaling receptor activity	GO:0010469	9.87	BMP2 CALCA FGF23 IGF1 PTH TNFRSF11B
3	osteoblast differentiation	GO:0001649	9.86	BGLAP BMP2 RUNX2 SP7
4	animal organ morphogenesis	GO:0009887	9.85	BMP2 TNFSF11 VDR
5	cellular calcium ion homeostasis	GO:0006874	9.84	CALCA PTH VDR
6	tumor necrosis factor-mediated signaling pathway	GO:0033209	9.81	TNFRSF11A TNFRSF11B TNFSF11
7	bone development	GO:0060348	9.79	BGLAP PHEX TNFSF11
8	monocyte chemotaxis	GO:0002548	9.77	CALCA TNFRSF11A TNFSF11
9	positive regulation of osteoblast differentiation	GO:0045669	9.76	BMP2 IGF1 LRP5 RUNX2
10	response to vitamin D	GO:0033280	9.69	BGLAP PHEX PTH
11	positive regulation of bone resorption	GO:0045780	9.67	TNFRSF11A TNFSF11
12	mammary gland alveolus development	GO:0060749	9.67	TNFRSF11A TNFSF11
13	positive regulation of glycogen biosynthetic process	GO:0045725	9.67	IGF1 PTH
14	osteoblast development	GO:0002076	9.67	BGLAP LRP5 RUNX2
15	regulation of osteoclast differentiation	GO:0045670	9.66	BGLAP TNFSF11
16	positive regulation of ossification	GO:0045778	9.65	BMP2 PTH
17	negative regulation of bone resorption	GO:0045779	9.65	CALCA TNFRSF11B
18	response to inorganic substance	GO:0010035	9.65	BGLAP TNFRSF11B
19	response to magnesium ion	GO:0032026	9.64	FGF23 TNFRSF11B
20	vitamin D metabolic process	GO:0042359	9.64	FGF23 VDR
21	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus	GO:1901522	9.63	BMP2 RUNX2
22	phosphate ion homeostasis	GO:0055062	9.62	FGF23 PTH
23	regulation of odontogenesis of dentin-containing tooth	GO:0042487	9.61	BMP2 RUNX2
24	cellular response to vitamin D	GO:0071305	9.61	BGLAP FGF23 PHEX
25	bone mineralization involved in bone maturation	GO:0035630	9.6	BMP2 IGF1
26	TNFSF11-mediated signaling pathway	GO:0071847	9.58	TNFRSF11A TNFSF11
27	positive regulation of vitamin D 24-hydroxylase activity	GO:0010980	9.58	FGF23 VDR
28	response to sodium phosphate	GO:1904383	9.57	FGF23 PHEX
29	bone mineralization	GO:0030282	9.56	BGLAP BMP2 PHEX PTH
30	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	GO:0071848	9.55	TNFRSF11A TNFSF11
31	positive regulation of fever generation by positive regulation of prostaglandin secretion	GO:0071812	9.54	TNFRSF11A TNFSF11
32	cellular response to parathyroid hormone stimulus	GO:0071374	9.54	FGF23 PHEX SOST
33	ossification	GO:0001503	9.5	ACP5 BGLAP BMP2 RUNX2 SOST TNFRSF11A
34	bone resorption	GO:0045453	9.46	ACP5 CTSK PTH TNFSF11
35	skeletal system development	GO:0001501	9.23	BGLAP BMP2 IGF1 PHEX PTH RUNX2
36	positive regulation of transcription by RNA polymerase II	GO:0045944	10.06	BMP2 IGF1 LRP5 NFATC1 PTH RUNX2
37	positive regulation of gene expression	GO:0010628	10.02	BMP2 IGF1 RUNX2 TNFSF11 VDR
38	positive regulation of transcription, DNA-templated	GO:0045893	10.02	BMP2 FGF23 IGF1 LRP5 NFATC1 RUNX2

Molecular functions related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	8.8	CALCA IGF1 PTH

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