MCID: BNR001
MIFTS: 27

Bone Remodeling Disease

Categories: Bone diseases
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Aliases & Classifications for Bone Remodeling Disease

MalaCards integrated aliases for Bone Remodeling Disease:

Name: Bone Remodeling Disease 11 14

Classifications:



External Ids:

Disease Ontology 11 DOID:0080005

Summaries for Bone Remodeling Disease

Disease Ontology: 11 A bone disease that results in formation or resorption abnormalities located in bone.

MalaCards based summary: Bone Remodeling Disease is related to rickets and fibrous dysplasia. An important gene associated with Bone Remodeling Disease is MIR214 (MicroRNA 214), and among its related pathways/superpathways are Vitamin D receptor pathway and MicroRNAs in cardiomyocyte hypertrophy. Affiliated tissues include bone, and related phenotypes are limbs/digits/tail and cellular

Related Diseases for Bone Remodeling Disease

Diseases related to Bone Remodeling Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 rickets 32.4 PTH FGF23 CALCA BGLAP
2 fibrous dysplasia 32.4 TNFSF11 FGF23 CALCA BGLAP
3 familial expansile osteolysis 32.4 TNFSF11 SOST NFATC1 CTSK ACP5
4 osteomalacia 32.4 TNFSF11 SOST PTH FGF23 CALCA BGLAP
5 endosteal hyperostosis, autosomal dominant 32.3 TNFSF11 SP7 SOST PTH NFATC1 CTSK
6 bone resorption disease 31.9 TNFSF11 SP7 SOST RUNX2 PTH NFATC1
7 hyperostosis 11.1
8 malignant ovarian brenner tumor 10.5 TNFSF11 PTH CALCA
9 gorham's disease 10.5 TNFSF11 PTH CALCA
10 osteoblastoma 10.5 TNFSF11 PTH FGF23 BGLAP
11 tetanic cataract 10.5 PTH CALCA
12 osteopetrosis, autosomal dominant 2 10.5 TNFSF11 CTSK BGLAP ACP5
13 chronic apical periodontitis 10.5 TNFSF11 RUNX2 NFATC1
14 diffuse idiopathic skeletal hyperostosis 10.5 SOST PTH BMP2 BGLAP
15 dental pulp necrosis 10.5 TNFSF11 RUNX2 BMP2 BGLAP
16 ossification of the posterior longitudinal ligament of spine 10.5 RUNX2 MIR140 BMP2 BGLAP
17 hypervitaminosis d 10.5 PTH FGF23 CALCA
18 hypophosphatemic rickets, x-linked dominant 10.5 SOST PTH FGF23 BGLAP
19 sclerosteosis 1 10.5 SP7 SOST BGLAP
20 nontoxic goiter 10.5 PTH CALCA BGLAP
21 osteopetrosis, autosomal recessive 2 10.5 TNFSF11 NFATC1 CTSK ACP5
22 enthesopathy 10.5 SOST PTH FGF23
23 periodontitis 10.5 TNFSF11 RUNX2 CTSK BGLAP ACP5
24 giant cell reparative granuloma 10.5 TNFSF11 PTH CALCA
25 teeth hard tissue disease 10.5 TNFSF11 RUNX2 BGLAP ACP5
26 spondylolysis 10.5 PTH CTSK BMP2
27 exostosis 10.5 SOST RUNX2 BMP2 BGLAP
28 osseous heteroplasia, progressive 10.5 RUNX2 PTH BMP2 BGLAP
29 pycnodysostosis 10.5 TNFSF11 SOST CTSK BGLAP ACP5
30 bone osteosarcoma 10.5 TNFSF11 RUNX2 MIR133A1 BGLAP
31 metaphyseal dysplasia 10.5 SOST RUNX2 PTH FGF23 ACP5
32 phosphorus metabolism disease 10.5 SOST RUNX2 PTH FGF23 BGLAP
33 osteitis fibrosa 10.5 SOST PTH FGF23 CALCA BGLAP
34 hypophosphatasia 10.5 SOST RUNX2 PTH FGF23 BGLAP
35 chronic recurrent multifocal osteomyelitis 10.5 TNFSF11 BMP2 BGLAP
36 hypocalcemia, autosomal dominant 1 10.5 PTH FGF23 CALCA BGLAP
37 enchondromatosis, multiple, ollier type 10.5 TNFSF11 RUNX2 PTH BMP2 ACP5
38 substernal goiter 10.5 PTH CALCA
39 camurati-engelmann disease 10.5 SP7 SOST RUNX2 BGLAP ACP5
40 hypophosphatemia 10.5 SOST PTH FGF23 BGLAP
41 secondary hyperparathyroidism 10.5 PTH FGF23 CALCA BGLAP ACP5
42 bone deterioration disease 10.5 MIR223 MIR140 MIR133A1 BMP2
43 benign giant cell tumor 10.5 TNFSF11 FGF23 CTSK CALCA BGLAP
44 cartilage disease 10.5 RUNX2 MIR140 BMP2
45 autoimmune disease of musculoskeletal system 10.5 TNFSF11 MIR23A MIR223 MIR214 MIR140
46 dental pulp disease 10.5 RUNX2 BMP2 BGLAP
47 degenerative disc disease 10.5 MIR223 MIR140 MIR133A1 BMP2
48 osteoporosis-pseudoglioma syndrome 10.5 TNFSF11 SP7 SOST
49 male reproductive system disease 10.5 MIR335 MIR223 MIR214 MIR140 MIR133A1
50 hyperphosphatemia 10.5 RUNX2 PTH FGF23 BMP2 BGLAP

Graphical network of the top 20 diseases related to Bone Remodeling Disease:



Diseases related to Bone Remodeling Disease

Symptoms & Phenotypes for Bone Remodeling Disease

MGI Mouse Phenotypes related to Bone Remodeling Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 10.1 ACP5 BMP2 CTSK FGF23 MIR140 MIR188
2 cellular MP:0005384 9.93 BGLAP BMP2 CTSK MIR133A1 MIR188 MIR214
3 craniofacial MP:0005382 9.8 BMP2 CTSK MIR140 NFATC1 PTH RUNX2
4 respiratory system MP:0005388 9.56 CALCA CTSK FGF23 MIR223 NFATC1 RUNX2
5 skeleton MP:0005390 9.47 ACP5 BGLAP BMP2 CALCA CTSK FGF23

Drugs & Therapeutics for Bone Remodeling Disease

Search Clinical Trials, NIH Clinical Center for Bone Remodeling Disease

Genetic Tests for Bone Remodeling Disease

Anatomical Context for Bone Remodeling Disease

Organs/tissues related to Bone Remodeling Disease:

FMA: Bone
MalaCards : Bone

Publications for Bone Remodeling Disease

Articles related to Bone Remodeling Disease:

# Title Authors PMID Year
1
Peripheral Blood Mononuclear Cells Spontaneous Osteoclastogenesis: Mechanisms Driving the Process and Clinical Relevance in Skeletal Disease. 62
26284737 2016
2
Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature. 62
25230058 2014
3
Central control of bone formation. 62
11368306 2001
4
Chronic familial hyperphosphatasemia. 62
725042 1978

Variations for Bone Remodeling Disease

Expression for Bone Remodeling Disease

Search GEO for disease gene expression data for Bone Remodeling Disease.

Pathways for Bone Remodeling Disease

GO Terms for Bone Remodeling Disease

Cellular components related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RISC complex GO:0016442 9.8 MIR550A1 MIR335 MIR23A MIR223 MIR214 MIR140
2 extracellular space GO:0005615 9.66 TNFSF11 SOST PTH MIR550A1 MIR335 MIR23A

Biological processes related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 miRNA-mediated gene silencing GO:0035195 10.28 MIR133A1 MIR140 MIR188 MIR214 MIR223 MIR23A
2 osteoblast differentiation GO:0001649 10.11 SP7 RUNX2 BMP2 BGLAP
3 skeletal system development GO:0001501 10.07 BGLAP BMP2 PTH RUNX2
4 bone mineralization GO:0030282 10.02 PTH BMP2 BGLAP
5 bone development GO:0060348 9.97 TNFSF11 BMP2 BGLAP
6 calcium ion homeostasis GO:0055074 9.89 TNFSF11 PTH FGF23
7 negative regulation of BMP signaling pathway GO:0030514 9.88 SOST MIR214 MIR140
8 response to sodium phosphate GO:1904383 9.87 RUNX2 FGF23
9 negative regulation of osteoblast differentiation GO:0045668 9.86 MIR214 MIR140 FGF23
10 bone resorption GO:0045453 9.86 TNFSF11 PTH CTSK ACP5
11 cellular response to zinc ion starvation GO:0034224 9.85 SP7 CTSK BGLAP
12 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.84 RUNX2 BMP2
13 positive regulation of gene expression GO:0010628 9.8 TNFSF11 RUNX2 PTH MIR23A MIR223 MIR140
14 mononuclear cell differentiation GO:1903131 9.76 NFATC1 CTSK
15 negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 9.62 MIR223 MIR214 MIR140 MIR133A1
16 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.61 MIR223 MIR214 MIR140
17 negative regulation of BMP secretion GO:2001285 9.48 MIR214 MIR140
18 miRNA-mediated gene silencing by mRNA destabilization GO:0035279 9.46 MIR140 MIR214 MIR223 MIR23A
19 ossification GO:0001503 9.32 TNFSF11 SOST RUNX2 CALCA BMP2 BGLAP

Molecular functions related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.43 MIR335 MIR23A MIR223 MIR214 MIR140 MIR133A1
2 mRNA base-pairing translational repressor activity GO:1903231 9.17 MIR335 MIR23A MIR223 MIR214 MIR188 MIR140

Sources for Bone Remodeling Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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