MCID: BNR001
MIFTS: 29

Bone Remodeling Disease

Categories: Bone diseases

Aliases & Classifications for Bone Remodeling Disease

MalaCards integrated aliases for Bone Remodeling Disease:

Name: Bone Remodeling Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080005

Summaries for Bone Remodeling Disease

Disease Ontology : 12 A bone disease that results in formation or resorption abnormalities located in bone.

MalaCards based summary : Bone Remodeling Disease is related to hyperostosis and fibrous dysplasia. An important gene associated with Bone Remodeling Disease is PTH (Parathyroid Hormone), and among its related pathways/superpathways are MicroRNAs in cancer and Rheumatoid arthritis. Affiliated tissues include bone, kidney and breast, and related phenotypes are craniofacial and limbs/digits/tail

Wikipedia : 73 Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the... more...

Related Diseases for Bone Remodeling Disease

Diseases related to Bone Remodeling Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 hyperostosis 32.5 SOST LRP5 FGF23
2 fibrous dysplasia 32.4 TNFSF11 FGF23 CALCA BGLAP
3 rickets 32.4 PTH PHEX FGF23 BGLAP
4 osteomalacia 32.4 PTH PHEX FGF23 CALCA BGLAP
5 endosteal hyperostosis, autosomal dominant 32.1 TNFSF11 SP7 SOST PTH PHEX NFATC1
6 bone resorption disease 31.7 TNFSF11 SP7 SOST RUNX2 PTH NFATC1
7 familial expansile osteolysis 11.1
8 malignant ovarian brenner tumor 10.6 TNFSF11 PTH CALCA
9 gorham's disease 10.6 TNFSF11 PTH CALCA
10 kummell's disease 10.6 TNFSF11 SOST CALCA
11 substernal goiter 10.6 PTH CALCA
12 hypervitaminosis d 10.6 PTH FGF23 CALCA
13 nontoxic goiter 10.6 PTH CALCA BGLAP
14 giant cell reparative granuloma 10.6 TNFSF11 PTH CALCA
15 osteopetrosis, autosomal dominant 2 10.6 TNFSF11 BGLAP ACP5
16 chondrodysplasia, blomstrand type 10.6 TNFSF11 PTH BGLAP
17 vitamin d-dependent rickets 10.6 PTH PHEX BGLAP
18 oncogenic osteomalacia 10.6 PTH PHEX FGF23
19 dental abscess 10.5 PTH PHEX FGF23
20 osteitis fibrosa 10.5 PTH FGF23 CALCA BGLAP
21 dental pulp necrosis 10.5 TNFSF11 BMP2 BGLAP
22 hypophosphatemic rickets with hypercalciuria, hereditary 10.5 PTH PHEX FGF23
23 multicentric carpotarsal osteolysis syndrome 10.5 TNFSF11 CTSK BGLAP ACP5
24 periapical periodontitis 10.5 TNFSF11 RUNX2 CTSK ACP5
25 pycnodysostosis 10.5 TNFSF11 SOST CTSK ACP5
26 ossification of the posterior longitudinal ligament of spine 10.5 RUNX2 BMP2 BGLAP
27 enthesopathy 10.5 PTH PHEX FGF23
28 enchondromatosis, multiple, ollier type 10.5 RUNX2 PTH ACP5
29 metaphyseal chondrodysplasia, jansen type 10.5 PTH PHEX FGF23
30 hypocalcemia, autosomal dominant 1 10.5 PTH FGF23 CALCA BGLAP
31 root resorption 10.5 TNFSF11 RUNX2 CTSK CALCA
32 dental pulp disease 10.5 RUNX2 BMP2 BGLAP
33 autosomal recessive hypophosphatemic rickets 10.5 SOST PTH PHEX FGF23
34 hypophosphatemic rickets, autosomal dominant 10.5 PTH PHEX FGF23
35 bone osteosarcoma 10.5 TNFSF11 RUNX2 MIR133A1 BGLAP
36 osteopetrosis, autosomal recessive 2 10.5 TNFSF11 NFATC1 CTSK ACP5
37 teeth hard tissue disease 10.5 TNFSF11 BGLAP ACP5
38 osteopetrosis, autosomal recessive 8 10.5 TNFSF11 NFATC1 CTSK ACP5
39 osseous heteroplasia, progressive 10.5 RUNX2 PTH BMP2 BGLAP
40 pseudohypoparathyroidism 10.5 PTH CALCA BGLAP
41 sclerosteosis 1 10.5 SP7 SOST LRP5 BGLAP
42 exostosis 10.5 SOST CALCA BMP2 BGLAP
43 bone giant cell tumor 10.5 TNFSF11 PTH CTSK CALCA ACP5
44 tumoral calcinosis, hyperphosphatemic, familial, 1 10.5 PTH PHEX FGF23
45 cherubism 10.5 TNFSF11 NFATC1 CALCA
46 hyperthyroidism 10.5 PTH CALCA BGLAP ACP5
47 osteoporosis-pseudoglioma syndrome 10.5 SOST RUNX2 LRP5
48 hypoparathyroidism 10.5 PTH FGF23 CALCA BGLAP
49 hypophosphatemia 10.5 PTH PHEX FGF23 BGLAP
50 benign giant cell tumor 10.5 TNFSF11 FGF23 CTSK CALCA BGLAP

Graphical network of the top 20 diseases related to Bone Remodeling Disease:



Diseases related to Bone Remodeling Disease

Symptoms & Phenotypes for Bone Remodeling Disease

MGI Mouse Phenotypes related to Bone Remodeling Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.76 BMP2 CTSK LRP5 NFATC1 PHEX PTH
2 limbs/digits/tail MP:0005371 9.7 BMP2 CTSK FGF23 LRP5 NFATC1 PHEX
3 skeleton MP:0005390 9.4 BGLAP BMP2 CTSK FGF23 LRP5 NFATC1

Drugs & Therapeutics for Bone Remodeling Disease

Search Clinical Trials , NIH Clinical Center for Bone Remodeling Disease

Genetic Tests for Bone Remodeling Disease

Anatomical Context for Bone Remodeling Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Remodeling Disease:

19
Bone

MalaCards organs/tissues related to Bone Remodeling Disease:

40
Bone, Kidney, Breast

Publications for Bone Remodeling Disease

Articles related to Bone Remodeling Disease:

# Title Authors PMID Year
1
Peripheral Blood Mononuclear Cells Spontaneous Osteoclastogenesis: Mechanisms Driving the Process and Clinical Relevance in Skeletal Disease. 61
26284737 2016
2
Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature. 61
25230058 2014
3
Central control of bone formation. 61
11368306 2001
4
Chronic familial hyperphosphatasemia. 61
725042 1978

Variations for Bone Remodeling Disease

Expression for Bone Remodeling Disease

Search GEO for disease gene expression data for Bone Remodeling Disease.

Pathways for Bone Remodeling Disease

GO Terms for Bone Remodeling Disease

Cellular components related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.4 TNFSF11 SOST PTH MIR335 MIR23A MIR140

Biological processes related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.12 TNFSF11 SP7 RUNX2 PTH NFATC1 LRP5
2 positive regulation of transcription, DNA-templated GO:0045893 10.03 SOST RUNX2 NFATC1 LRP5 FGF23 BMP2
3 gene silencing by miRNA GO:0035195 9.99 MIR335 MIR23A MIR214 MIR188 MIR140 MIR133A1
4 positive regulation of gene expression GO:0010628 9.95 TNFSF11 RUNX2 MIR140 MIR133A1 FGF23 BMP2
5 negative regulation of gene expression GO:0010629 9.92 PTH MIR214 MIR140 BMP2
6 cell-cell signaling GO:0007267 9.9 PTH PHEX CALCA BMP2
7 positive regulation of osteoblast differentiation GO:0045669 9.77 RUNX2 LRP5 BMP2
8 osteoblast differentiation GO:0001649 9.76 SP7 RUNX2 BMP2 BGLAP
9 bone mineralization GO:0030282 9.71 PHEX BMP2 BGLAP
10 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.7 MIR214 MIR140 MIR133A1
11 skeletal system development GO:0001501 9.65 RUNX2 PTH PHEX BMP2 BGLAP
12 positive regulation of ossification GO:0045778 9.62 PTH BMP2
13 bone development GO:0060348 9.62 TNFSF11 PHEX LRP5 BGLAP
14 regulation of osteoclast differentiation GO:0045670 9.61 TNFSF11 BGLAP
15 positive regulation of osteoblast proliferation GO:0033690 9.61 LRP5 BMP2
16 response to vitamin D GO:0033280 9.61 PTH PHEX BGLAP
17 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.58 RUNX2 BMP2
18 osteoblast development GO:0002076 9.58 RUNX2 LRP5 BGLAP
19 phosphate ion homeostasis GO:0055062 9.57 PTH FGF23
20 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.55 RUNX2 BMP2
21 cellular response to vitamin D GO:0071305 9.54 PHEX FGF23 BGLAP
22 response to sodium phosphate GO:1904383 9.49 PHEX FGF23
23 cellular response to parathyroid hormone stimulus GO:0071374 9.33 SOST PHEX FGF23
24 bone resorption GO:0045453 9.26 TNFSF11 PTH CTSK ACP5
25 ossification GO:0001503 9.1 TNFSF11 SOST RUNX2 BMP2 BGLAP ACP5

Molecular functions related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.02 MIR23A MIR214 MIR188 MIR140 MIR133A1

Sources for Bone Remodeling Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....