MCID: BNR001
MIFTS: 32

Bone Remodeling Disease

Categories: Bone diseases

Aliases & Classifications for Bone Remodeling Disease

MalaCards integrated aliases for Bone Remodeling Disease:

Name: Bone Remodeling Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080005

Summaries for Bone Remodeling Disease

Disease Ontology : 12 A bone disease that results in formation or resorption abnormalities located in bone.

MalaCards based summary : Bone Remodeling Disease is related to fibrous dysplasia and rickets. An important gene associated with Bone Remodeling Disease is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. Affiliated tissues include bone, breast and kidney, and related phenotypes are no effect and cellular

Wikipedia : 77 Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the... more...

Related Diseases for Bone Remodeling Disease

Diseases related to Bone Remodeling Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 fibrous dysplasia 32.1 BGLAP CALCA FGF23 IGF1
2 rickets 32.0 BGLAP FGF23 PHEX PTH VDR
3 osteomalacia 31.9 BGLAP CALCA FGF23 PHEX PTH VDR
4 hyperostosis 31.9 FGF23 IGF1 LRP5 SOST TNFRSF11B
5 endosteal hyperostosis, autosomal dominant 31.7 BMP2 CLCN7 CTSK LRP5 TNFRSF11B TNFSF11
6 bone resorption disease 30.0 ACP5 BGLAP BMP2 CALCA CTSK IGF1
7 axial osteomalacia 10.5 BGLAP PTH
8 extraskeletal chondroma 10.5 BGLAP PTH
9 fibrogenesis imperfecta ossium 10.5 CALCA PTH TNFRSF11B
10 osteitis fibrosa 10.5 BGLAP CALCA PTH
11 kummell's disease 10.5 SOST TNFRSF11B TNFSF11
12 hypophosphatasia, adult 10.5 BGLAP CALCA PTH
13 multicentric reticulohistiocytosis 10.4 TNFRSF11B TNFSF11
14 pseudoarthrosis 10.4 BMP2 PTH
15 autosomal recessive malignant osteopetrosis 10.4 CLCN7 TNFSF11
16 hypercalcemia, infantile, 1 10.4 CALCA PTH VDR
17 villonodular synovitis 10.4 ACP5 TNFSF11
18 bone fracture 10.4 BGLAP BMP2
19 sclerosteosis 1 10.4 SOST SP7
20 periodontitis, chronic 10.4 TNFRSF11B TNFSF11
21 polyarticular onset juvenile idiopathic arthritis 10.4 TNFRSF11A TNFRSF11B TNFSF11
22 hypervitaminosis d 10.4 FGF23 PTH VDR
23 metaphyseal chondrodysplasia, jansen type 10.4 CALCA FGF23 PTH
24 calciphylaxis 10.4 FGF23 PTH VDR
25 hemophilic arthropathy 10.4 TNFRSF11A TNFRSF11B TNFSF11
26 idiopathic hypercalciuria 10.4 BGLAP TNFSF11 VDR
27 oncogenic osteomalacia 10.4 FGF23 PHEX PTH
28 osteopetrosis, autosomal recessive 7 10.4 TNFRSF11A TNFSF11
29 familial expansile osteolysis 10.4 TNFRSF11A TNFRSF11B TNFSF11
30 hypophosphatemic rickets, x-linked dominant 10.4 FGF23 PHEX PTH
31 tooth ankylosis 10.4 BMP2 TNFSF11
32 chronic apical periodontitis 10.4 TNFRSF11B TNFSF11
33 breast leiomyosarcoma 10.4 TNFRSF11A TNFSF11
34 aneurysmal bone cysts 10.4 CALCA TNFRSF11A TNFSF11
35 hypoparathyroidism 10.4 BGLAP FGF23 PTH
36 craniodiaphyseal dysplasia 10.4 CALCA LRP5 SOST
37 impaired renal function disease 10.4 BGLAP FGF23 PTH SOST
38 hypophosphatemic rickets with hypercalciuria, hereditary 10.4 FGF23 PHEX PTH
39 camurati-engelmann disease 10.4 ACP5 BGLAP LRP5
40 ossification of the posterior longitudinal ligament of spine 10.4 BGLAP BMP2 RUNX2
41 uremia 10.4 PTH TNFRSF11B VDR
42 osseous heteroplasia, progressive 10.4 BGLAP BMP2 RUNX2
43 bone giant cell tumor 10.4 ACP5 CALCA CTSK TNFSF11
44 parathyroid adenoma 10.4 BGLAP CALCA PTH VDR
45 calcinosis 10.4 CALCA FGF23 PHEX
46 vitamin d-dependent rickets, type 2a 10.4 PHEX VDR
47 van buchem disease 10.4 LRP5 SOST VDR
48 hypophosphatemic rickets, x-linked recessive 10.4 FGF23 PHEX VDR
49 endocrine organ benign neoplasm 10.4 CALCA IGF1 PTH
50 opsismodysplasia 10.4 FGF23 PHEX

Graphical network of the top 20 diseases related to Bone Remodeling Disease:



Diseases related to Bone Remodeling Disease

Symptoms & Phenotypes for Bone Remodeling Disease

GenomeRNAi Phenotypes related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ACP5 BGLAP BMP2 CALCA CLCN7 CTSK

MGI Mouse Phenotypes related to Bone Remodeling Disease:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 BMP2 CLCN7 CTSK IGF1 LRP5 NFATC1
2 growth/size/body region MP:0005378 10.36 BMP2 CLCN7 CTSK FGF23 IGF1 LRP5
3 craniofacial MP:0005382 10.29 BMP2 CLCN7 CTSK LRP5 NFATC1 PHEX
4 cardiovascular system MP:0005385 10.28 BMP2 FGF23 IGF1 LRP5 NFATC1 PHEX
5 hematopoietic system MP:0005397 10.28 BMP2 CLCN7 CTSK FGF23 IGF1 LRP5
6 homeostasis/metabolism MP:0005376 10.28 BMP2 CLCN7 CTSK FGF23 IGF1 LRP5
7 immune system MP:0005387 10.24 BMP2 CLCN7 CTSK FGF23 IGF1 LRP5
8 limbs/digits/tail MP:0005371 10.19 BMP2 CLCN7 CTSK FGF23 IGF1 LRP5
9 endocrine/exocrine gland MP:0005379 10.18 CTSK FGF23 IGF1 LRP5 PHEX PTH
10 digestive/alimentary MP:0005381 10.1 BMP2 CTSK FGF23 NFATC1 PHEX RUNX2
11 mortality/aging MP:0010768 10.03 BMP2 CLCN7 FGF23 IGF1 LRP5 NFATC1
12 integument MP:0010771 9.97 CLCN7 FGF23 IGF1 NFATC1 RPL24 RUNX2
13 respiratory system MP:0005388 9.61 CLCN7 CTSK FGF23 IGF1 NFATC1 RUNX2
14 skeleton MP:0005390 9.55 BMP2 CLCN7 CTSK FGF23 IGF1 LRP5

Drugs & Therapeutics for Bone Remodeling Disease

Search Clinical Trials , NIH Clinical Center for Bone Remodeling Disease

Genetic Tests for Bone Remodeling Disease

Anatomical Context for Bone Remodeling Disease

MalaCards organs/tissues related to Bone Remodeling Disease:

42
Bone, Breast, Kidney

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Remodeling Disease:

20
Bone

Publications for Bone Remodeling Disease

Variations for Bone Remodeling Disease

Expression for Bone Remodeling Disease

Search GEO for disease gene expression data for Bone Remodeling Disease.

Pathways for Bone Remodeling Disease

GO Terms for Bone Remodeling Disease

Cellular components related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.65 BGLAP BMP2 CALCA CTSK FGF23 IGF1
2 extracellular space GO:0005615 9.32 BGLAP BMP2 CALCA CTSK FGF23 IGF1

Biological processes related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.92 BMP2 CALCA PHEX PTH TNFRSF11A
2 regulation of signaling receptor activity GO:0010469 9.87 BMP2 CALCA FGF23 IGF1 PTH TNFRSF11B
3 osteoblast differentiation GO:0001649 9.86 BGLAP BMP2 RUNX2 SP7
4 animal organ morphogenesis GO:0009887 9.85 BMP2 TNFSF11 VDR
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.81 TNFRSF11A TNFRSF11B TNFSF11
6 bone development GO:0060348 9.79 BGLAP PHEX TNFSF11
7 monocyte chemotaxis GO:0002548 9.77 CALCA TNFRSF11A TNFSF11
8 positive regulation of osteoblast differentiation GO:0045669 9.76 BMP2 IGF1 LRP5 RUNX2
9 response to vitamin D GO:0033280 9.69 BGLAP PHEX PTH
10 positive regulation of bone resorption GO:0045780 9.67 TNFRSF11A TNFSF11
11 mammary gland alveolus development GO:0060749 9.67 TNFRSF11A TNFSF11
12 positive regulation of glycogen biosynthetic process GO:0045725 9.67 IGF1 PTH
13 osteoblast development GO:0002076 9.67 BGLAP LRP5 RUNX2
14 cellular calcium ion homeostasis GO:0006874 9.66 PTH VDR
15 regulation of osteoclast differentiation GO:0045670 9.66 BGLAP TNFSF11
16 positive regulation of ossification GO:0045778 9.65 BMP2 PTH
17 negative regulation of bone resorption GO:0045779 9.65 CALCA TNFRSF11B
18 response to inorganic substance GO:0010035 9.65 BGLAP TNFRSF11B
19 response to magnesium ion GO:0032026 9.64 FGF23 TNFRSF11B
20 vitamin D metabolic process GO:0042359 9.64 FGF23 VDR
21 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.63 BMP2 RUNX2
22 phosphate ion homeostasis GO:0055062 9.62 FGF23 PTH
23 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.61 BMP2 RUNX2
24 cellular response to vitamin D GO:0071305 9.61 BGLAP FGF23 PHEX
25 bone mineralization involved in bone maturation GO:0035630 9.6 BMP2 IGF1
26 TNFSF11-mediated signaling pathway GO:0071847 9.58 TNFRSF11A TNFSF11
27 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.58 FGF23 VDR
28 response to sodium phosphate GO:1904383 9.57 FGF23 PHEX
29 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.55 TNFRSF11A TNFSF11
30 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.54 TNFRSF11A TNFSF11
31 cellular response to parathyroid hormone stimulus GO:0071374 9.54 FGF23 PHEX SOST
32 ossification GO:0001503 9.5 ACP5 BGLAP BMP2 RUNX2 SOST TNFRSF11A
33 bone resorption GO:0045453 9.46 ACP5 CTSK PTH TNFSF11
34 bone mineralization GO:0030282 9.43 BGLAP BMP2 PHEX
35 skeletal system development GO:0001501 9.23 BGLAP BMP2 IGF1 PHEX PTH RUNX2
36 positive regulation of transcription by RNA polymerase II GO:0045944 10.06 BMP2 IGF1 LRP5 NFATC1 PTH RUNX2
37 positive regulation of gene expression GO:0010628 10.02 BMP2 IGF1 RUNX2 TNFSF11 VDR
38 positive regulation of transcription, DNA-templated GO:0045893 10.02 BMP2 FGF23 IGF1 LRP5 NFATC1 RUNX2

Molecular functions related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA IGF1 PTH

Sources for Bone Remodeling Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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