Bone Remodeling Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BNR001 MIFTS: 28	Bone Remodeling Disease Categories: Bone diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Bone Remodeling Disease

MalaCards integrated aliases for Bone Remodeling Disease:

Name: Bone Remodeling Disease ¹² ¹⁵

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0080005

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Summaries for Bone Remodeling Disease

Disease Ontology : ¹² A bone disease that results in formation or resorption abnormalities located in bone.

MalaCards based summary : Bone Remodeling Disease is related to hyperostosis and fibrous dysplasia. An important gene associated with Bone Remodeling Disease is PTH (Parathyroid Hormone), and among its related pathways/superpathways are MicroRNAs in cancer and RANK Signaling in Osteoclasts. Affiliated tissues include bone, and related phenotypes are craniofacial and limbs/digits/tail

Wikipedia : ⁷⁴ Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the... more...

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Related Diseases for Bone Remodeling Disease

Diseases related to Bone Remodeling Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)

#	Related Disease	Score	Top Affiliating Genes
1	hyperostosis	33.0	TNFRSF11B SOST FGF23
2	fibrous dysplasia	32.8	TNFSF11 TNFRSF11B RUNX2 FGF23 CALCA BGLAP
3	rickets	32.8	VDR PTH PHEX FGF23 CALCA BGLAP
4	osteomalacia	32.7	VDR TNFSF11 SOST PTH PHEX FGF23
5	endosteal hyperostosis, autosomal dominant	32.7	TNFSF11 TNFRSF11B SP7 SOST PHEX NFATC1
6	bone resorption disease	32.1	VDR TNFSF11 TNFRSF11B SP7 SOST RUNX2
7	familial expansile osteolysis	11.2
8	malignant ovarian brenner tumor	10.8	TNFSF11 PTH CALCA
9	gorham's disease	10.8	TNFSF11 PTH CALCA
10	paget disease of bone 5, juvenile-onset	10.8	TNFSF11 TNFRSF11B CALCA
11	villonodular synovitis	10.8	TNFSF11 ACP5
12	polyarticular onset juvenile idiopathic arthritis	10.8	TNFSF11 TNFRSF11B
13	nontoxic goiter	10.8	PTH CALCA BGLAP
14	kummell's disease	10.8	TNFSF11 TNFRSF11B SOST
15	osteopetrosis, autosomal dominant 2	10.8	TNFSF11 BGLAP ACP5
16	giant cell reparative granuloma	10.8	TNFSF11 PTH CALCA
17	hypercalcemia, infantile, 1	10.8	VDR PTH CALCA
18	chondrodysplasia, blomstrand type	10.8	TNFSF11 PTH BGLAP
19	idiopathic hypercalciuria	10.8	VDR TNFSF11 BGLAP
20	sclerosteosis 1	10.8	SP7 SOST BGLAP
21	hemophilic arthropathy	10.8	TNFSF11 TNFRSF11B
22	bone benign neoplasm	10.8	PTH FGF23 BGLAP
23	oncogenic osteomalacia	10.8	PTH PHEX FGF23
24	dental abscess	10.8	PTH PHEX FGF23
25	hypophosphatemic rickets with hypercalciuria, hereditary	10.8	PTH PHEX FGF23
26	spondyloarthropathy 1	10.7	TNFSF11 TNFRSF11B PTH BGLAP
27	pigmented villonodular synovitis	10.7	TNFSF11 TNFRSF11B ACP5
28	substernal goiter	10.7	PTH CALCA
29	periapical periodontitis	10.7	TNFSF11 TNFRSF11B CTSK ACP5
30	periodontitis, chronic	10.7	TNFSF11 TNFRSF11B
31	synovitis	10.7	TNFSF11 TNFRSF11B ACP5
32	calciphylaxis	10.7	VDR PTH FGF23
33	pycnodysostosis	10.7	TNFSF11 SOST CTSK ACP5
34	osseous heteroplasia, progressive	10.7	RUNX2 PTH BGLAP
35	hypophosphatemic rickets, x-linked dominant	10.7	PTH PHEX FGF23
36	enchondromatosis, multiple, ollier type	10.7	RUNX2 PTH ACP5
37	bone osteosarcoma	10.7	RUNX2 MIR133A1 BGLAP
38	craniometaphyseal dysplasia, autosomal dominant	10.7	TNFSF11 SP7 RUNX2 BGLAP
39	metaphyseal chondrodysplasia, jansen type	10.7	PTH PHEX FGF23
40	parathyroid adenoma	10.7	VDR PTH CALCA BGLAP
41	hypervitaminosis d	10.7	VDR PTH FGF23 CALCA
42	hypophosphatemic rickets, autosomal dominant	10.7	PTH PHEX FGF23
43	autosomal recessive hypophosphatemic rickets	10.7	PTH PHEX FGF23
44	osteopetrosis, autosomal recessive 2	10.7	TNFSF11 NFATC1 CTSK ACP5
45	multicentric carpotarsal osteolysis syndrome	10.7	TNFSF11 TNFRSF11B CTSK BGLAP ACP5
46	osteitis fibrosa	10.7	SOST PTH FGF23 CALCA BGLAP
47	pseudohypoparathyroidism	10.7	PTH CALCA BGLAP
48	aggressive periodontitis	10.7	VDR TNFSF11 TNFRSF11B
49	hyperthyroidism	10.7	PTH CALCA BGLAP ACP5
50	teeth hard tissue disease	10.7	TNFSF11 TNFRSF11B ACP5

Graphical network of the top 20 diseases related to Bone Remodeling Disease:

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Symptoms & Phenotypes for Bone Remodeling Disease

MGI Mouse Phenotypes related to Bone Remodeling Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	craniofacial	MP:0005382	9.76	CTSK NFATC1 PHEX PTH RUNX2 TNFRSF11B
2	limbs/digits/tail	MP:0005371	9.7	CTSK FGF23 NFATC1 PHEX PTH RUNX2
3	skeleton	MP:0005390	9.4	BGLAP CTSK FGF23 NFATC1 PHEX PTH

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Drugs & Therapeutics for Bone Remodeling Disease

Search Clinical Trials , NIH Clinical Center for Bone Remodeling Disease

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Genetic Tests for Bone Remodeling Disease

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Anatomical Context for Bone Remodeling Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Remodeling Disease:

¹⁹

Bone

MalaCards organs/tissues related to Bone Remodeling Disease:

⁴⁰

Bone

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Publications for Bone Remodeling Disease

Articles related to Bone Remodeling Disease:

#	Title	Authors	PMID	Year
1	Peripheral Blood Mononuclear Cells Spontaneous Osteoclastogenesis: Mechanisms Driving the Process and Clinical Relevance in Skeletal Disease. ⁶¹	Salamanna F...Fini M	26284737	2016
2	Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature. ⁶¹	Anic B...Cerovec M	25230058	2014
3	Central control of bone formation. ⁶¹	Takeda S...Karsenty G	11368306	2001
4	Chronic familial hyperphosphatasemia. ⁶¹	Iancu TC...Front D	725042	1978

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Genes for Bone Remodeling Disease

Genes related to Bone Remodeling Disease (0 elite genes):

(show top 50) (show all 72)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PTH	Parathyroid Hormone	Protein Coding	10.33	DISEASES inferred ¹⁵
2	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	10.26	DISEASES inferred ¹⁵
3	TNFSF11	TNF Superfamily Member 11	Protein Coding	10.19	DISEASES inferred ¹⁵
4	MIR188	MicroRNA 188	RNA Gene	9.59	DISEASES inferred ¹⁵ ¹⁵
5	TNFRSF11B	TNF Receptor Superfamily Member 11b	Protein Coding	9.56	DISEASES inferred ¹⁵
6	SOST	Sclerostin	Protein Coding	9.5	DISEASES inferred ¹⁵
7	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	9.46	DISEASES inferred ¹⁵
8	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	9.41	DISEASES inferred ¹⁵
9	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	9.31	DISEASES inferred ¹⁵
10	MIR133A1	MicroRNA 133a-1	RNA Gene	9.29	DISEASES inferred ¹⁵ ¹⁵
11	CTSK	Cathepsin K	Protein Coding	9.24	DISEASES inferred ¹⁵
12	MIR214	MicroRNA 214	RNA Gene	9.24	DISEASES inferred ¹⁵ ¹⁵
13	FGF23	Fibroblast Growth Factor 23	Protein Coding	9.19	DISEASES inferred ¹⁵
14	MIR23A	MicroRNA 23a	RNA Gene	9.05	DISEASES inferred ¹⁵ ¹⁵
15	MIR140	MicroRNA 140	RNA Gene	8.93	DISEASES inferred ¹⁵ ¹⁵
16	VDR	Vitamin D Receptor	Protein Coding	8.88	DISEASES inferred ¹⁵
17	SP7	Sp7 Transcription Factor	Protein Coding	8.85	DISEASES inferred ¹⁵
18	PHEX	Phosphate Regulating Endopeptidase Homolog X-Linked	Protein Coding	8.83	DISEASES inferred ¹⁵
19	MIR335	MicroRNA 335	RNA Gene	8.79	DISEASES inferred ¹⁵ ¹⁵
20	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	8.74	DISEASES inferred ¹⁵
21	SERPINA3	Serpin Family A Member 3	Protein Coding	8.7	DISEASES inferred ¹⁵ ¹⁵
22	LRP5	LDL Receptor Related Protein 5	Protein Coding	8.68	DISEASES inferred ¹⁵
23	BMP2	Bone Morphogenetic Protein 2	Protein Coding	8.67	DISEASES inferred ¹⁵
24	TNFRSF11A	TNF Receptor Superfamily Member 11a	Protein Coding	8.5	DISEASES inferred ¹⁵
25	ESR1	Estrogen Receptor 1	Protein Coding	8.49	DISEASES inferred ¹⁵
26	ERCC6	ERCC Excision Repair 6, Chromatin Remodeling Factor	Protein Coding	8.48	DISEASES inferred ¹⁵ ¹⁵
27	IGF1	Insulin Like Growth Factor 1	Protein Coding	8.44	DISEASES inferred ¹⁵
28	SPP1	Secreted Phosphoprotein 1	Protein Coding	8.36	DISEASES inferred ¹⁵
29	H2AC18	H2A Clustered Histone 18	Protein Coding	8.35	DISEASES inferred ¹⁵ ¹⁵
30	IL6	Interleukin 6	Protein Coding	8.34	DISEASES inferred ¹⁵
31	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	8.32	DISEASES inferred ¹⁵ ¹⁵
32	CLCN7	Chloride Voltage-Gated Channel 7	Protein Coding	8.3	DISEASES inferred ¹⁵
33	MIR550A1	MicroRNA 550a-1	RNA Gene	8.28	DISEASES inferred ¹⁵ ¹⁵
34	IBSP	Integrin Binding Sialoprotein	Protein Coding	8.2	DISEASES inferred ¹⁵
35	TNF	Tumor Necrosis Factor	Protein Coding	8.19	DISEASES inferred ¹⁵
36	DKK1	Dickkopf WNT Signaling Pathway Inhibitor 1	Protein Coding	8.18	DISEASES inferred ¹⁵
37	HECTD4	HECT Domain E3 Ubiquitin Protein Ligase 4	Protein Coding	8.13	DISEASES inferred ¹⁵
38	CTNNB1	Catenin Beta 1	Protein Coding	8.06	DISEASES inferred ¹⁵
39	CYP27B1	Cytochrome P450 Family 27 Subfamily B Member 1	Protein Coding	8.02	DISEASES inferred ¹⁵
40	KL	Klotho	Protein Coding	8.01	DISEASES inferred ¹⁵
41	COL1A1	Collagen Type I Alpha 1 Chain	Protein Coding	8	DISEASES inferred ¹⁵
42	FDPS	Farnesyl Diphosphate Synthase	Protein Coding	7.98	DISEASES inferred ¹⁵
43	TCIRG1	T Cell Immune Regulator 1, ATPase H+ Transporting V0 Subunit A3	Protein Coding	7.97	DISEASES inferred ¹⁵
44	DCSTAMP	Dendrocyte Expressed Seven Transmembrane Protein	Protein Coding	7.95	DISEASES inferred ¹⁵
45	MIR93	MicroRNA 93	RNA Gene	7.95	DISEASES inferred ¹⁵ ¹⁵
46	INS	Insulin	Protein Coding	7.94	DISEASES inferred ¹⁵
47	MEPE	Matrix Extracellular Phosphoglycoprotein	Protein Coding	7.93	DISEASES inferred ¹⁵
48	MIR122	MicroRNA 122	RNA Gene	7.92	DISEASES inferred ¹⁵ ¹⁵
49	RPL24	Ribosomal Protein L24	Protein Coding	7.88	DISEASES inferred ¹⁵
50	PTHLH	Parathyroid Hormone Like Hormone	Protein Coding	7.87	DISEASES inferred ¹⁵

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Variations for Bone Remodeling Disease

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Expression for Bone Remodeling Disease

Search GEO for disease gene expression data for Bone Remodeling Disease.

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Pathways for Bone Remodeling Disease

Pathways related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

(show all 12)

#	Super pathways	Score	Top Affiliating Genes
1	MicroRNAs in cancer ³⁶	12.3	MIR335 MIR23A MIR214 MIR133A1
2	RANK Signaling in Osteoclasts ⁶³ Show member pathways Apoptosis and survival APRIL and BAFF signaling ²² APRIL Pathway ⁶³ BAFF in B-Cell Signaling ⁶³ RANK Pathway ⁶³ RANKL/RANK (Receptor activator of NFKB (ligand)) Signaling Pathway ¹	12.25	TNFSF11 TNFRSF11B NFATC1 CTSK ACP5
3	Osteoclast differentiation ³⁶	11.87	TNFSF11 TNFRSF11B NFATC1 CTSK ACP5
4	Parathyroid hormone synthesis, secretion and action ³⁶	11.73	VDR TNFSF11 SOST RUNX2 PTH FGF23
5	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁴	11.71	SP7 RUNX2 PTH BGLAP
6	Rheumatoid arthritis ³⁶	11.67	TNFSF11 PTH CTSK ACP5
7	FGF signaling pathway ¹	11.33	RUNX2 FGF23 BGLAP
8	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	11.25	VDR TNFSF11 RUNX2 PTH BGLAP
9	Osteoclast Signaling ¹	10.83	TNFSF11 TNFRSF11B CTSK ACP5
10	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	10.82	VDR TNFSF11 TNFRSF11B RUNX2 PTH CALCA
11	Osteoblast Signaling ¹	10.5	TNFSF11 TNFRSF11B PTH FGF23 BGLAP
12	Vitamin D Metabolism ¹	10.49	VDR PTH

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GO Terms for Bone Remodeling Disease

Cellular components related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.4	TNFSF11 TNFRSF11B SOST PTH MIR335 MIR23A

Biological processes related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

(show all 21)

#	Name	GO ID	Score	Top Affiliating Genes
1	gene silencing by miRNA	GO:0035195	9.93	MIR335 MIR23A MIR214 MIR188 MIR140 MIR133A1
2	positive regulation of gene expression	GO:0010628	9.92	VDR TNFSF11 RUNX2 MIR140 MIR133A1
3	osteoblast differentiation	GO:0001649	9.76	SP7 RUNX2 BGLAP
4	cellular calcium ion homeostasis	GO:0006874	9.75	VDR PTH CALCA
5	bone development	GO:0060348	9.69	TNFSF11 PHEX BGLAP
6	negative regulation of vascular smooth muscle cell proliferation	GO:1904706	9.65	MIR214 MIR140 MIR133A1
7	osteoblast development	GO:0002076	9.6	RUNX2 BGLAP
8	response to inorganic substance	GO:0010035	9.59	TNFRSF11B BGLAP
9	negative regulation of bone resorption	GO:0045779	9.57	TNFRSF11B CALCA
10	regulation of osteoclast differentiation	GO:0045670	9.56	TNFSF11 BGLAP
11	vitamin D metabolic process	GO:0042359	9.55	VDR FGF23
12	ossification	GO:0001503	9.55	TNFSF11 SOST RUNX2 BGLAP ACP5
13	response to magnesium ion	GO:0032026	9.54	TNFRSF11B FGF23
14	response to vitamin D	GO:0033280	9.54	PTH PHEX BGLAP
15	cellular response to vitamin D	GO:0071305	9.5	PHEX FGF23 BGLAP
16	phosphate ion homeostasis	GO:0055062	9.49	PTH FGF23
17	response to sodium phosphate	GO:1904383	9.43	PHEX FGF23
18	cellular response to parathyroid hormone stimulus	GO:0071374	9.43	SOST PHEX FGF23
19	positive regulation of vitamin D 24-hydroxylase activity	GO:0010980	9.4	VDR FGF23
20	bone resorption	GO:0045453	9.26	TNFSF11 PTH CTSK ACP5
21	skeletal system development	GO:0001501	9.1	VDR TNFRSF11B RUNX2 PTH PHEX BGLAP

Molecular functions related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA binding involved in posttranscriptional gene silencing	GO:1903231	9.02	MIR23A MIR214 MIR188 MIR140 MIR133A1

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Sources for Bone Remodeling Disease

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