MCID: BNR001
MIFTS: 28

Bone Remodeling Disease

Categories: Bone diseases

Aliases & Classifications for Bone Remodeling Disease

MalaCards integrated aliases for Bone Remodeling Disease:

Name: Bone Remodeling Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0080005

Summaries for Bone Remodeling Disease

Disease Ontology : 12 A bone disease that results in formation or resorption abnormalities located in bone.

MalaCards based summary : Bone Remodeling Disease is related to hyperostosis and fibrous dysplasia. An important gene associated with Bone Remodeling Disease is PTH (Parathyroid Hormone), and among its related pathways/superpathways are MicroRNAs in cancer and RANK Signaling in Osteoclasts. Affiliated tissues include bone, and related phenotypes are craniofacial and limbs/digits/tail

Wikipedia : 74 Bone remodeling (or bone metabolism) is a lifelong process where mature bone tissue is removed from the... more...

Related Diseases for Bone Remodeling Disease

Diseases related to Bone Remodeling Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 148)
# Related Disease Score Top Affiliating Genes
1 hyperostosis 33.0 TNFRSF11B SOST FGF23
2 fibrous dysplasia 32.8 TNFSF11 TNFRSF11B RUNX2 FGF23 CALCA BGLAP
3 rickets 32.8 VDR PTH PHEX FGF23 CALCA BGLAP
4 osteomalacia 32.7 VDR TNFSF11 SOST PTH PHEX FGF23
5 endosteal hyperostosis, autosomal dominant 32.7 TNFSF11 TNFRSF11B SP7 SOST PHEX NFATC1
6 bone resorption disease 32.1 VDR TNFSF11 TNFRSF11B SP7 SOST RUNX2
7 familial expansile osteolysis 11.2
8 malignant ovarian brenner tumor 10.8 TNFSF11 PTH CALCA
9 gorham's disease 10.8 TNFSF11 PTH CALCA
10 paget disease of bone 5, juvenile-onset 10.8 TNFSF11 TNFRSF11B CALCA
11 villonodular synovitis 10.8 TNFSF11 ACP5
12 polyarticular onset juvenile idiopathic arthritis 10.8 TNFSF11 TNFRSF11B
13 nontoxic goiter 10.8 PTH CALCA BGLAP
14 kummell's disease 10.8 TNFSF11 TNFRSF11B SOST
15 osteopetrosis, autosomal dominant 2 10.8 TNFSF11 BGLAP ACP5
16 giant cell reparative granuloma 10.8 TNFSF11 PTH CALCA
17 hypercalcemia, infantile, 1 10.8 VDR PTH CALCA
18 chondrodysplasia, blomstrand type 10.8 TNFSF11 PTH BGLAP
19 idiopathic hypercalciuria 10.8 VDR TNFSF11 BGLAP
20 sclerosteosis 1 10.8 SP7 SOST BGLAP
21 hemophilic arthropathy 10.8 TNFSF11 TNFRSF11B
22 bone benign neoplasm 10.8 PTH FGF23 BGLAP
23 oncogenic osteomalacia 10.8 PTH PHEX FGF23
24 dental abscess 10.8 PTH PHEX FGF23
25 hypophosphatemic rickets with hypercalciuria, hereditary 10.8 PTH PHEX FGF23
26 spondyloarthropathy 1 10.7 TNFSF11 TNFRSF11B PTH BGLAP
27 pigmented villonodular synovitis 10.7 TNFSF11 TNFRSF11B ACP5
28 substernal goiter 10.7 PTH CALCA
29 periapical periodontitis 10.7 TNFSF11 TNFRSF11B CTSK ACP5
30 periodontitis, chronic 10.7 TNFSF11 TNFRSF11B
31 synovitis 10.7 TNFSF11 TNFRSF11B ACP5
32 calciphylaxis 10.7 VDR PTH FGF23
33 pycnodysostosis 10.7 TNFSF11 SOST CTSK ACP5
34 osseous heteroplasia, progressive 10.7 RUNX2 PTH BGLAP
35 hypophosphatemic rickets, x-linked dominant 10.7 PTH PHEX FGF23
36 enchondromatosis, multiple, ollier type 10.7 RUNX2 PTH ACP5
37 bone osteosarcoma 10.7 RUNX2 MIR133A1 BGLAP
38 craniometaphyseal dysplasia, autosomal dominant 10.7 TNFSF11 SP7 RUNX2 BGLAP
39 metaphyseal chondrodysplasia, jansen type 10.7 PTH PHEX FGF23
40 parathyroid adenoma 10.7 VDR PTH CALCA BGLAP
41 hypervitaminosis d 10.7 VDR PTH FGF23 CALCA
42 hypophosphatemic rickets, autosomal dominant 10.7 PTH PHEX FGF23
43 autosomal recessive hypophosphatemic rickets 10.7 PTH PHEX FGF23
44 osteopetrosis, autosomal recessive 2 10.7 TNFSF11 NFATC1 CTSK ACP5
45 multicentric carpotarsal osteolysis syndrome 10.7 TNFSF11 TNFRSF11B CTSK BGLAP ACP5
46 osteitis fibrosa 10.7 SOST PTH FGF23 CALCA BGLAP
47 pseudohypoparathyroidism 10.7 PTH CALCA BGLAP
48 aggressive periodontitis 10.7 VDR TNFSF11 TNFRSF11B
49 hyperthyroidism 10.7 PTH CALCA BGLAP ACP5
50 teeth hard tissue disease 10.7 TNFSF11 TNFRSF11B ACP5

Graphical network of the top 20 diseases related to Bone Remodeling Disease:



Diseases related to Bone Remodeling Disease

Symptoms & Phenotypes for Bone Remodeling Disease

MGI Mouse Phenotypes related to Bone Remodeling Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.76 CTSK NFATC1 PHEX PTH RUNX2 TNFRSF11B
2 limbs/digits/tail MP:0005371 9.7 CTSK FGF23 NFATC1 PHEX PTH RUNX2
3 skeleton MP:0005390 9.4 BGLAP CTSK FGF23 NFATC1 PHEX PTH

Drugs & Therapeutics for Bone Remodeling Disease

Search Clinical Trials , NIH Clinical Center for Bone Remodeling Disease

Genetic Tests for Bone Remodeling Disease

Anatomical Context for Bone Remodeling Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Bone Remodeling Disease:

19
Bone

MalaCards organs/tissues related to Bone Remodeling Disease:

40
Bone

Publications for Bone Remodeling Disease

Articles related to Bone Remodeling Disease:

# Title Authors PMID Year
1
Peripheral Blood Mononuclear Cells Spontaneous Osteoclastogenesis: Mechanisms Driving the Process and Clinical Relevance in Skeletal Disease. 61
26284737 2016
2
Clinical features of the SAPHO syndrome and their role in choosing the therapeutic approach: report of four patients and review of the literature. 61
25230058 2014
3
Central control of bone formation. 61
11368306 2001
4
Chronic familial hyperphosphatasemia. 61
725042 1978

Variations for Bone Remodeling Disease

Expression for Bone Remodeling Disease

Search GEO for disease gene expression data for Bone Remodeling Disease.

Pathways for Bone Remodeling Disease

GO Terms for Bone Remodeling Disease

Cellular components related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.4 TNFSF11 TNFRSF11B SOST PTH MIR335 MIR23A

Biological processes related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 gene silencing by miRNA GO:0035195 9.93 MIR335 MIR23A MIR214 MIR188 MIR140 MIR133A1
2 positive regulation of gene expression GO:0010628 9.92 VDR TNFSF11 RUNX2 MIR140 MIR133A1
3 osteoblast differentiation GO:0001649 9.76 SP7 RUNX2 BGLAP
4 cellular calcium ion homeostasis GO:0006874 9.75 VDR PTH CALCA
5 bone development GO:0060348 9.69 TNFSF11 PHEX BGLAP
6 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.65 MIR214 MIR140 MIR133A1
7 osteoblast development GO:0002076 9.6 RUNX2 BGLAP
8 response to inorganic substance GO:0010035 9.59 TNFRSF11B BGLAP
9 negative regulation of bone resorption GO:0045779 9.57 TNFRSF11B CALCA
10 regulation of osteoclast differentiation GO:0045670 9.56 TNFSF11 BGLAP
11 vitamin D metabolic process GO:0042359 9.55 VDR FGF23
12 ossification GO:0001503 9.55 TNFSF11 SOST RUNX2 BGLAP ACP5
13 response to magnesium ion GO:0032026 9.54 TNFRSF11B FGF23
14 response to vitamin D GO:0033280 9.54 PTH PHEX BGLAP
15 cellular response to vitamin D GO:0071305 9.5 PHEX FGF23 BGLAP
16 phosphate ion homeostasis GO:0055062 9.49 PTH FGF23
17 response to sodium phosphate GO:1904383 9.43 PHEX FGF23
18 cellular response to parathyroid hormone stimulus GO:0071374 9.43 SOST PHEX FGF23
19 positive regulation of vitamin D 24-hydroxylase activity GO:0010980 9.4 VDR FGF23
20 bone resorption GO:0045453 9.26 TNFSF11 PTH CTSK ACP5
21 skeletal system development GO:0001501 9.1 VDR TNFRSF11B RUNX2 PTH PHEX BGLAP

Molecular functions related to Bone Remodeling Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.02 MIR23A MIR214 MIR188 MIR140 MIR133A1

Sources for Bone Remodeling Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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