MCID: BNR002
MIFTS: 54

Bone Resorption Disease

Categories: Bone diseases

Aliases & Classifications for Bone Resorption Disease

MalaCards integrated aliases for Bone Resorption Disease:

Name: Bone Resorption Disease 12 15
Bone Resorption 45

Classifications:



External Ids:

Disease Ontology 12 DOID:0080011
MeSH 45 D001862

Summaries for Bone Resorption Disease

Disease Ontology : 12 A bone remodeling disease that results in an abnormal decrease of bone density or mass.

MalaCards based summary : Bone Resorption Disease, also known as bone resorption, is related to osteopetrosis and osteitis fibrosa. An important gene associated with Bone Resorption Disease is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are RANK Signaling in Osteoclasts and Osteoclast differentiation. The drugs AT-101 and Nitric Oxide have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and prostate, and related phenotypes are cellular and growth/size/body region

Wikipedia : 77 Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the... more...

Related Diseases for Bone Resorption Disease

Diseases related to Bone Resorption Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
# Related Disease Score Top Affiliating Genes
1 osteopetrosis 32.5 CTSK LRP5 TNFRSF11A TNFSF11
2 osteitis fibrosa 32.2 BGLAP CALCA PTH
3 paget disease of bone 5, juvenile-onset 32.0 CALCA TNFRSF11A TNFRSF11B TNFSF11
4 glucocorticoid-induced osteoporosis 31.8 ACP5 BGLAP BMP2 CALCA IGF1 PTH
5 periodontitis 31.3 BGLAP CTSK RUNX2 TNFRSF11B TNFSF11
6 periodontal disease 31.1 TNFRSF11A TNFRSF11B TNFSF11
7 rheumatoid arthritis 30.9 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
8 periapical periodontitis 30.7 ACP5 TNFRSF11A TNFRSF11B TNFSF11
9 idiopathic hypercalciuria 30.7 BGLAP TNFSF11 VDR
10 osteoporotic fracture 30.7 ESR1 TNFRSF11B
11 hyperparathyroidism 30.6 ACP5 BGLAP CALCA PTH TNFRSF11B VDR
12 giant cell tumor 30.6 BGLAP CALCA CTSK TNFRSF11A TNFRSF11B TNFSF11
13 paget's disease of bone 30.5 BGLAP CALCA TNFRSF11A TNFRSF11B TNFSF11
14 bone giant cell tumor 30.5 ACP5 CALCA CTSK TNFSF11
15 primary hyperparathyroidism 30.5 BGLAP CALCA PTH VDR
16 uremia 30.4 PTH TNFRSF11B VDR
17 rickets 30.3 BGLAP PTH VDR
18 multicentric reticulohistiocytosis 30.3 TNFRSF11B TNFSF11
19 osteonecrosis 30.3 ACP5 BGLAP BMP2 PTH RUNX2 TNFRSF11B
20 bone inflammation disease 30.3 ACP5 BGLAP CTSK TNFRSF11B TNFSF11
21 hemophilic arthropathy 30.2 TNFRSF11A TNFRSF11B TNFSF11
22 renal osteodystrophy 30.2 BGLAP CALCA PTH SOST TNFRSF11B VDR
23 osteogenesis imperfecta, type i 30.2 BGLAP IGF1 TNFRSF11B
24 osteomalacia 30.1 BGLAP CALCA PTH VDR
25 hypervitaminosis d 30.1 PTH VDR
26 bone cancer 30.0 ESR1 TNFRSF11A TNFSF11
27 root resorption 30.0 CALCA CTSK RUNX2 TNFRSF11A TNFRSF11B TNFSF11
28 breast adenocarcinoma 30.0 CALCA CTSK ESR1 TNFSF11
29 chronic kidney failure 30.0 BGLAP CALCA IGF1 PTH TNFRSF11B VDR
30 osteoporosis 30.0 ACP5 BGLAP BMP2 CALCA CTSK ESR1
31 insulin-like growth factor i 29.9 BGLAP ESR1 IGF1
32 calciphylaxis 29.7 PTH VDR
33 bone disease 29.4 ACP5 BGLAP CALCA CTSK IGF1 LRP5
34 bone remodeling disease 29.0 ACP5 BGLAP BMP2 CALCA CTSK ESR1
35 hajdu-cheney syndrome 11.0
36 failure of tooth eruption, primary 11.0
37 paget disease of bone 3 11.0
38 singleton-merten syndrome 1 11.0
39 osteopetrosis, autosomal recessive 5 11.0
40 paget disease of bone 2, early-onset 11.0
41 osteopetrosis, autosomal dominant 1 11.0
42 osteopetrosis, autosomal recessive 8 11.0
43 hyperparathyroidism 4 11.0
44 ameloblastic carcinoma 11.0
45 arthritis 10.6
46 axial osteomalacia 10.5 BGLAP PTH
47 extraskeletal chondroma 10.5 BGLAP PTH
48 breast cancer 10.5
49 pseudoarthrosis 10.5 BMP2 PTH
50 fibrogenesis imperfecta ossium 10.4 CALCA PTH TNFRSF11B

Graphical network of the top 20 diseases related to Bone Resorption Disease:



Diseases related to Bone Resorption Disease

Symptoms & Phenotypes for Bone Resorption Disease

MGI Mouse Phenotypes related to Bone Resorption Disease:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.37 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
2 growth/size/body region MP:0005378 10.33 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
3 homeostasis/metabolism MP:0005376 10.25 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
4 cardiovascular system MP:0005385 10.24 BMP2 ESR1 IGF1 LRP5 NFATC1 PTH
5 craniofacial MP:0005382 10.21 BMP2 CTSK LRP5 NFATC1 PTH RUNX2
6 hematopoietic system MP:0005397 10.21 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
7 immune system MP:0005387 10.18 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
8 endocrine/exocrine gland MP:0005379 10.13 CTSK ESR1 IGF1 LRP5 PTH RUNX2
9 limbs/digits/tail MP:0005371 10.13 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
10 digestive/alimentary MP:0005381 10.1 BMP2 CTSK ESR1 NFATC1 RUNX2 SLC51A
11 mortality/aging MP:0010768 9.97 BMP2 ESR1 IGF1 LRP5 NFATC1 PTH
12 integument MP:0010771 9.92 ESR1 IGF1 NFATC1 RPL24 RUNX2 TNFRSF11A
13 respiratory system MP:0005388 9.56 CTSK ESR1 IGF1 NFATC1 RUNX2 SP7
14 skeleton MP:0005390 9.5 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1

Drugs & Therapeutics for Bone Resorption Disease

Drugs for Bone Resorption Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 421)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
AT-101 Approved, Investigational Phase 4,Phase 3 90141-22-3, 652-67-5 12597
2
Nitric Oxide Approved Phase 4,Phase 3 10102-43-9 145068
3
Isosorbide Dinitrate Approved, Investigational Phase 4,Phase 3 87-33-2 6883
4 sodium fluoride Approved Phase 4 7681-49-4
5
Teriparatide Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 52232-67-4 16133850
6
Denosumab Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 615258-40-7
7
Parathyroid hormone Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 9002-64-6
8
Zoledronic Acid Approved Phase 4,Phase 3,Phase 2,Phase 1 118072-93-8 68740
9
Testosterone undecanoate Approved, Investigational Phase 4,Phase 2,Early Phase 1 5949-44-0
10
Methyltestosterone Approved Phase 4,Phase 2,Early Phase 1 58-18-4 6010
11
Testosterone Approved, Experimental, Investigational Phase 4,Phase 2,Early Phase 1 58-22-0, 481-30-1 6013 10204
12
Testosterone enanthate Approved Phase 4,Phase 2,Early Phase 1 315-37-7 9416
13
Anastrozole Approved, Investigational Phase 4,Phase 2 120511-73-1 2187
14
Adalimumab Approved Phase 4,Phase 3,Not Applicable 331731-18-1 16219006
15
Alendronate Approved Phase 4,Phase 2,Phase 3,Not Applicable 66376-36-1, 121268-17-5 2088
16
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
17
Ethinyl Estradiol Approved Phase 4,Phase 3 57-63-6 5991
18
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable 50-28-2 5757
19
Desogestrel Approved Phase 4 54024-22-5 40973
20
Polyestradiol phosphate Approved Phase 4,Phase 3,Not Applicable 28014-46-2
21
Etonogestrel Approved, Investigational Phase 4 54048-10-1 40976 6917715
22
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
23
Risedronate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 105462-24-6 5245
24
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1,Phase 2 9004-61-9 53477741
25
Phylloquinone Approved, Investigational Phase 4,Phase 3,Not Applicable 84-80-0
26
Atorvastatin Approved Phase 4 134523-00-5 60823
27
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
28
Salmon Calcitonin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 47931-85-1 16129616
29
Potassium Citrate Approved, Investigational, Vet_approved Phase 4,Not Applicable
30
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 68-04-2
31
Etidronic acid Approved Phase 4,Phase 3,Phase 1,Phase 2 7414-83-7, 2809-21-4 3305
32
Ethanol Approved Phase 4 64-17-5 702
33
Liraglutide Approved Phase 4 204656-20-2 44147092
34
Mecasermin Approved, Investigational Phase 4 68562-41-4
35
Norelgestromin Approved, Investigational Phase 4 53016-31-2 13752005
36
tannic acid Approved Phase 4,Not Applicable 1401-55-4
37
Benzocaine Approved, Investigational Phase 4,Not Applicable 94-09-7, 1994-09-7 2337
38
Demeclocycline Approved Phase 4 127-33-3 5311063
39
Tetracycline Approved, Vet_approved Phase 4 60-54-8 5353990
40
Metronidazole Approved Phase 4 443-48-1 4173
41
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-70-2 271
42
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-14-6 5280793
43
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1406-16-2
44
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 67-97-0 5280795 6221
45
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 73-31-4 896
46
Menadione Approved, Nutraceutical Phase 4,Phase 3,Not Applicable 58-27-5 4055
47
Vitamin C Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 50-81-7 5785 54670067
48
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 77-92-9 311
49
Calcitriol Approved, Nutraceutical Phase 4,Phase 2 32222-06-3 134070 5280453
50
Menatetrenone Investigational Phase 4 863-61-6 5282367

Interventional clinical trials:

(show top 50) (show all 520)
# Name Status NCT ID Phase Drugs
1 Influence of Nitrates on Bone Remodeling and Endothelial Function in Patients With Type 2 Diabetes Mellitus Unknown status NCT02011620 Phase 4
2 Clinical and Microbiological Effects of an Essential Oils Solution Used as an Adjunct to Daily Oral Hygiene Practices in Chronic Periodontitis Patients in Supportive Care Unknown status NCT01195493 Phase 4
3 Bone Turnover in Type 2 Diabetes Patients Unknown status NCT00732121 Phase 4 Sitagliptin;Placebo
4 Bone Resorption, Osteoclastogenesis and Adalimumab Recruiting NCT02035800 Phase 4 Adalimumab
5 Alveolar Management Following Teeth Extraction Recruiting NCT03089619 Phase 4 Human-Spongiosa
6 Acute Effect of Teriparatide With Bisphosphonate or Denosumab on Bone Resorption Completed NCT01750086 Phase 4 Teriparatide 40-mcg subcutaneous injection;Denosumab Injection;Alendronate Oral Tablet
7 The Efficacy of Denosumab in Decreasing Periprosthetic Bone Loss in Patients With Total Knee Arthroplasty Completed NCT02760979 Phase 4 Denosumab;Placebo
8 A Study of Bone Turnover Markers in Post-Menopausal Women With Osteoporosis Treated With Monthly Boniva (Ibandronate) Completed NCT00303485 Phase 4 Placebo;Vitamin D and calcium supplementation;ibandronate [Bonviva/Boniva]
9 Sodium Alendronate in Non Surgical Periodontal Therapy Completed NCT02470611 Phase 4 Sodium alendronate
10 Effect of Full Length Parathyroid Hormone, PTH(1-84) or Strontium Ranelate on Bone Markers in Postmenopausal Women With Primary Osteoporosis (FP-006-IM) Completed NCT00479037 Phase 4 Full Length Parathyroid Hormone, PTH(1-84);Strontium Ranelate
11 Changes in Bone Turnover With Exposure to a GLP-1 Receptor Agonist Terminated NCT01381926 Phase 4 exenatide;Saline
12 Assessing the Impact of Contraceptives on Bone Health Using 41Ca Active, not recruiting NCT02367846 Phase 4 Combined Oral Contraceptive (COC);Contraceptive Vaginal Ring (CVR)
13 Does Omeprazole Decrease Intestinal Calcium Absorption? Completed NCT00582972 Phase 4 Omeprazole
14 Bone Mineral Changes Around Stemless and Stemmed Cementless Femoral Components Completed NCT00957970 Phase 4
15 A Multi-center Study to Evaluate Bone Loss, Survival Rate and Stability of SPI Implant Completed NCT02367261 Phase 4
16 A Multi-center Study to Evaluate Bone Loss, Survival Rate and Stability of ICE Implant Active, not recruiting NCT01960361 Phase 4
17 The Change of Bone Markers After Low Dose Alendronate in Postmenopausal Women With Bone Loss Completed NCT00460057 Phase 4 Alendronate
18 Enhancing Osteoporosis Therapy: Can We Open the Anabolic Window? Completed NCT01166958 Phase 4 Teriparatide;Raloxifene
19 POWER Point of Care Effect on Satisfaction of Treatment Completed NCT00549068 Phase 4 Risedronate Sodium (Actonel)
20 Efficacy and Safety of Alendronate in Chinese Children or Adolescents With Osteogenesis Imperfecta Completed NCT02303873 Phase 4 Alendronate
21 Stability of Implants Placed in Patients With Vitamin D Deficiency Using Sequential Drilling vs a Single Drilling Design Active, not recruiting NCT03695562 Phase 4
22 the Effect of Topical Application of Hyaluronic Acid on Immediate Dental Implant Not yet recruiting NCT03691467 Phase 4 Hyaluronic Acid
23 A Study of Ibandronate (Boniva) to Evaluate Bone Turnover Markers in Women With Treatment-Naive Postmenopausal Osteoporosis Completed NCT02598934 Phase 4 Ibandronate
24 Treatment With Zoledronic Acid Subsequent to Denosumab in Osteoporosis Active, not recruiting NCT03087851 Phase 4 Zoledronic Acid
25 Assessment of Immediate Implant Stability When Adding Mixture of Hyaluronic Acid and Melatonin Not yet recruiting NCT03692026 Phase 4 Hyaluronic acid and Melatonin Mixture
26 Prolonged Protection From Bone Disease in Multiple Myeloma Recruiting NCT02286830 Phase 4 Zoledronic acid
27 Combined Administration of Teripapartide and Antiresorptive Agents in Postmenopausal Osteoporosis Completed NCT01535027 Phase 4 teriparatide;teriparatide and raloxifene;teriparatide and alendronate
28 Denosumab Sequential Therapy Recruiting NCT03868033 Phase 4 Zoledronic Acid;Denosumab
29 The Effect of Vitamin K2 on Bone Turnover Completed NCT00548509 Phase 4 Menatetrenone (Vitamin K2)
30 Effect of Bisphosphonate on Bone Loss in Postmenopausal Women With Breast Cancer Initiating Aromatase Inhibitor Therapy Completed NCT00485953 Phase 4 risedronate
31 The Effects of Alendronate After Cure of Primary Hyperparathyroidism Withdrawn NCT00359385 Phase 4 Alendronate 70mg weekly
32 Atorvastatin as an Adjunct to DFDBA in Intrabony Defects Completed NCT03009097 Phase 4 DFDBA with atorvastatin
33 Consequences of Anti-interleukin 6 Immunotherapy Treatment for Rheumatoid Arthritis on Periodontium Terminated NCT01806974 Phase 4
34 The Effect Of Hyaluronic Acid And Melatonin With Systemic Administration of Vitamin C On Implant Stability After Immediate Implant in Anterior Region Not yet recruiting NCT03804177 Phase 4
35 Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism Completed NCT00837616 Phase 4 17 B estradiol orally;17 B estradiol
36 The Use of Intranasal Calcitonin to Improve Pain and Activity in Elderly Pelvic Ring Injuries Not yet recruiting NCT03812991 Phase 4 Miacalcin Calcitonin Salmon Nasal Spray
37 The Effects of Potassium Citrate on Bone Metabolism Completed NCT00357331 Phase 4 potassium citrate
38 Risedronate Sodium in Post Menopausal Osteoporosis Completed NCT00453492 Phase 4 risedronate sodium
39 Do Aromatase Inhibitors (AIs) Decrease Intestinal Calcium Absorption? Completed NCT00766532 Phase 4 Aromatase Inhibitor
40 Comparison of a Bone Product to Bone Dust in Ossification of Small Calvarial Defects. Withdrawn NCT01006148 Phase 4
41 Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis Completed NCT02808988 Phase 4
42 The Effect of Liraglutide on Bone Turnover, Bone Mass and Bone Cell Function Completed NCT02473809 Phase 4 Liraglutide;Placebo
43 Roflumilast on Markers of Bone Metabolism and Endothelial Function in COPD Completed NCT01745848 Phase 4 Roflumilast
44 Pilot Study for Zoledronic Acid to Prevent Bone Loss After Bariatric Surgery Enrolling by invitation NCT03424239 Phase 4 Zoledronic Acid
45 A Study Comparing Monthly Boniva (Ibandronate) and Weekly Risedronate in Women With Post-Menopausal Osteoporosis. Completed NCT00377234 Phase 4 Risedronate;ibandronate [Bonviva/Boniva]
46 Effects of Oral vs. Non-oral Contraceptives on the GH/IGF-1 Axis Completed NCT02367833 Phase 4 Combined Oral Contraceptive;Transdermal Contraceptive;Contraceptive Vaginal Ring
47 Efficacy of Zoledronic Acid in Enhancement of Early Stability of Cementless Primary Hip Prosthesis Completed NCT01218035 Phase 4 zoledronic acid
48 Testosterone Therapy and Bone Quality in Men With Diabetes and Hypogonadism Not yet recruiting NCT03887936 Phase 4 Testosterone gel 1.62%;Placebo
49 A Study to Evaluate Alendronate Sodium /Vitamin D3 Combination Tablets(FOSAMAX PLUS) Versus Calcitriol in the Treatment of Osteoporosis in Postmenopausal Women in China (MK-0217A-264) Completed NCT01350934 Phase 4 alendronate 70-mg/vitamin D3 5600 IU combination tablet (Fosamax Plus);Calcitriol
50 Effect Of Zoledronic Acid On Circulating And Bone Marrow-Residing Prostate Cancer Cells In Patients With Clinically Localized Prostate Cancer Completed NCT00219271 Phase 4 Zoledronic acid

Search NIH Clinical Center for Bone Resorption Disease

Cochrane evidence based reviews: bone resorption

Genetic Tests for Bone Resorption Disease

Anatomical Context for Bone Resorption Disease

MalaCards organs/tissues related to Bone Resorption Disease:

42
Bone, Breast, Prostate, Bone Marrow, T Cells, Monocytes, Endothelial

Publications for Bone Resorption Disease

Articles related to Bone Resorption Disease:

(show top 50) (show all 3008)
# Title Authors Year
1
MiR-146a-5p Expression in Peripheral CD14⁺ Monocytes from Patients with Psoriatic Arthritis Induces Osteoclast Activation, Bone Resorption, and Correlates with Clinical Response. ( 30658492 )
2019
2
Reduced bone formation in males and increased bone resorption in females drive bone loss in hemophilia A mice. ( 30700417 )
2019
3
Increased bone resorption in hemophilia. ( 29857920 )
2019
4
Constant hypoxia inhibits osteoclast differentiation and bone resorption by regulating phosphorylation of JNK and IκBα. ( 30604211 )
2019
5
Bone resorption in dogs with calcium oxalate urolithiasis and idiopathic hypercalciuria. ( 30641472 )
2019
6
Interferon gamma-1b does not increase markers of bone resorption in autosomal dominant osteopetrosis. ( 30889272 )
2019
7
Cumambrin A prevents OVX-induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways. ( 30807230 )
2019
8
Elevated Expression of Macrophage Migration Inhibitory Factor Promotes Inflammatory Bone Resorption Induced in a Mouse Model of Periradicular Periodontitis. ( 30737274 )
2019
9
Notch signaling pathway mediates alveolar bone resorption in apical periodontitis. ( 30798925 )
2019
10
Notch Signaling Pathway in Apical Periodontitis: Correlation with Bone Resorption Regulators and Proinflammatory Cytokines. ( 30580840 )
2019
11
Macrophage polarization in aseptic bone resorption around dental implants induced by Ti particles in a murine model. ( 30635919 )
2019
12
LncRNA AK077216 promotes RANKL-induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45. ( 30132869 )
2019
13
Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats. ( 30339914 )
2019
14
Aminothiazoles inhibit osteoclastogenesis and PGE2 production in LPS-stimulated co-cultures of periodontal ligament and RAW 264.7 cells, and RANKL-mediated osteoclastogenesis and bone resorption in PBMCs. ( 30506812 )
2019
15
Biomechanically stimulated chondrocytes promote osteoclastic bone resorption in the mandibular condyle. ( 30530236 )
2019
16
Impact of a zoledronate coating on early post-surgical implant stability and marginal bone resorption in the maxilla-A split-mouth randomized clinical trial. ( 30565741 )
2019
17
Acute hypercalcemia and excessive bone resorption following anti-RANKL withdrawal: Case report and brief literature review. ( 30572144 )
2019
18
Sphingosine-1-Phosphate Receptor 2 Controls Podosome Components Induced by RANKL Affecting Osteoclastogenesis and Bone Resorption. ( 30609675 )
2019
19
Bone resorption in autologous cryopreserved cranioplasty: quantitative evaluation, semiquantitative score and clinical significance. ( 30617716 )
2019
20
Osteoclasts secrete osteopontin into resorption lacunae during bone resorption. ( 30637455 )
2019
21
Tenofovir Causes Bone Loss via Decreased Bone Formation and Increased Bone Resorption, Which Can Be Counteracted by Dipyridamole in Mice. ( 30645771 )
2019
22
Modification of honeycomb bioceramic scaffolds for bone regeneration under the condition of excessive bone resorption. ( 30707498 )
2019
23
Beta-Cryptoxanthin Inhibits Lipopolysaccharide-Induced Osteoclast Differentiation and Bone Resorption via the Suppression of Inhibitor of NF-κB Kinase Activity. ( 30744180 )
2019
24
Periradicular inflammatory response, bone resorption, and cementum repair after sealing of furcation perforation with mineral trioxide aggregate (MTA Angelus™) or Biodentine™. ( 30864115 )
2019
25
A dried blood spot-based method to measure levels of tartrate-resistant acid phosphatase 5b (TRACP-5b), a marker of bone resorption. ( 30897260 )
2019
26
Bone Resorption Triggered by High Radial Stress: The Mechanism of Screw Loosening in Plate Fixation of Long Bone Fractures. ( 30908687 )
2019
27
Relationship between melatonin and bone resorption rhythms in premenopausal women. ( 29318392 )
2019
28
Relation of RANKL and OPG Levels with Bone Resorption in Patients with Acromegaly and Prolactinoma. ( 29895074 )
2018
29
Effects on bone resorption markers of continuing pamidronate or switching to zoledronic acid in patients with high risk bone metastases from breast cancer. ( 29204337 )
2018
30
Medication-related osteonecrosis of the jaw incidence in patients exposed concomitantly to bone resorption inhibitors and vascular endothelial growth factor receptor tyrosine kinase inhibitors: is it generalizable to all solid tumors? ( 29860712 )
2018
31
Sclerostin Antibody Reverses Bone Loss by Increasing Bone Formation and Decreasing Bone Resorption in a Rat Model of Male Osteoporosis. ( 29069393 )
2018
32
Multiple subperiosteal bone resorption in adult T-cell leukemia/lymphoma. ( 30190354 )
2018
33
Homocysteine levels are associated with bone resorption in pre-frail and frail Spanish women: The Toledo Study for Healthy Aging. ( 29704640 )
2018
34
Targeted delivery of p-coumaric acid encapsulated mannosylated liposomes to the synovial macrophages inhibits osteoclast formation and bone resorption in the rheumatoid arthritis animal model. ( 30339889 )
2018
35
Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone. ( 29379010 )
2018
36
Subchondral fracture begins from the bone resorption area in osteonecrosis of the femoral head: a micro-computerised tomography study. ( 29541811 )
2018
37
Incidence of medication-related osteonecrosis of the jaw in patients treated with both bone resorption inhibitors and vascular endothelial growth factor receptor tyrosine kinase inhibitors. ( 28963584 )
2018
38
Small molecule inhibitor RepSox prevented ovariectomy-induced osteoporosis by suppressing osteoclast differentiation and bone resorption. ( 30059597 )
2018
39
Hydroxysafflor Yellow A Promoted Bone Mineralization and Inhibited Bone Resorption Which Reversed Glucocorticoids-Induced Osteoporosis. ( 30069475 )
2018
40
Modeling and simulation of bone mineral density in Japanese osteoporosis patients treated with zoledronic acid using tartrate-resistant acid phosphatase 5b, a bone resorption marker. ( 29423715 )
2018
41
Bis‑enoxacin blocks alveolar bone resorption in rats with ovariectomy‑induced osteoporosis. ( 29257280 )
2018
42
Effects of Cynanchum wilfordii on osteoporosis with inhibition of bone resorption and induction of bone formation. ( 29257324 )
2018
43
Bu-Shen-Tong-Luo decoction prevents bone loss via inhibition of bone resorption and enhancement of angiogenesis in ovariectomy-induced osteoporosis of rats. ( 29317302 )
2018
44
Long-term testosterone depletion attenuates inflammatory bone resorption in the ligature-induced periodontal disease model. ( 29683497 )
2018
45
Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease. ( 29703905 )
2018
46
Simvastatin alleviates bone resorption in apical periodontitis possibly by inhibition of mitophagy-related osteoblast apoptosis. ( 30537112 )
2018
47
Alveolar bone resorption and Th1/Th17-associated immune response triggered during Aggregatibacter actinomycetemcomitans-induced experimental periodontitis are serotype-dependent. ( 30030845 )
2018
48
Effects of theaflavins on tissue inflammation and bone resorption on experimental periodontitis in rats. ( 30159985 )
2018
49
Differential effects of natural Curcumin and chemically modified curcumin on inflammation and bone resorption in model of experimental periodontitis. ( 29669267 )
2018
50
Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model. ( 29531138 )
2018

Variations for Bone Resorption Disease

Expression for Bone Resorption Disease

Search GEO for disease gene expression data for Bone Resorption Disease.

Pathways for Bone Resorption Disease

GO Terms for Bone Resorption Disease

Cellular components related to Bone Resorption Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 BGLAP BMP2 CALCA CTSK IGF1 PTH
2 extracellular space GO:0005615 9.28 BGLAP BMP2 CALCA CTSK IGF1 PTH

Biological processes related to Bone Resorption Disease according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.98 BMP2 IGF1 RUNX2 TNFSF11 VDR
2 positive regulation of transcription by RNA polymerase II GO:0045944 9.96 BMP2 ESR1 IGF1 LRP5 NFATC1 PTH
3 regulation of signaling receptor activity GO:0010469 9.93 BMP2 CALCA IGF1 PTH TNFRSF11B TNFSF11
4 cell-cell signaling GO:0007267 9.91 BMP2 CALCA PTH TNFRSF11A
5 positive regulation of transcription, DNA-templated GO:0045893 9.91 BMP2 ESR1 IGF1 LRP5 NFATC1 RUNX2
6 animal organ morphogenesis GO:0009887 9.83 BMP2 TNFSF11 VDR
7 positive regulation of DNA-binding transcription factor activity GO:0051091 9.82 ESR1 TNFRSF11A TNFSF11
8 cellular calcium ion homeostasis GO:0006874 9.81 CALCA PTH VDR
9 osteoblast differentiation GO:0001649 9.81 BGLAP BMP2 RUNX2 SP7
10 tumor necrosis factor-mediated signaling pathway GO:0033209 9.78 TNFRSF11A TNFRSF11B TNFSF11
11 response to estrogen GO:0043627 9.77 BGLAP ESR1 TNFRSF11B
12 monocyte chemotaxis GO:0002548 9.73 CALCA TNFRSF11A TNFSF11
13 bone mineralization GO:0030282 9.71 BGLAP BMP2 PTH
14 positive regulation of bone resorption GO:0045780 9.65 TNFRSF11A TNFSF11
15 positive regulation of glycogen biosynthetic process GO:0045725 9.64 IGF1 PTH
16 regulation of osteoclast differentiation GO:0045670 9.63 BGLAP TNFSF11
17 positive regulation of ossification GO:0045778 9.63 BMP2 PTH
18 negative regulation of bone resorption GO:0045779 9.62 CALCA TNFRSF11B
19 response to inorganic substance GO:0010035 9.62 BGLAP TNFRSF11B
20 positive regulation of osteoblast differentiation GO:0045669 9.62 BMP2 IGF1 LRP5 RUNX2
21 osteoblast development GO:0002076 9.61 BGLAP LRP5 RUNX2
22 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.59 BMP2 RUNX2
23 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.58 BMP2 RUNX2
24 mammary gland alveolus development GO:0060749 9.58 ESR1 TNFRSF11A TNFSF11
25 bone mineralization involved in bone maturation GO:0035630 9.57 BMP2 IGF1
26 TNFSF11-mediated signaling pathway GO:0071847 9.55 TNFRSF11A TNFSF11
27 mammary gland branching involved in pregnancy GO:0060745 9.52 ESR1 VDR
28 skeletal system development GO:0001501 9.5 BGLAP BMP2 IGF1 PTH RUNX2 TNFRSF11B
29 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.49 TNFRSF11A TNFSF11
30 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.48 TNFRSF11A TNFSF11
31 bone resorption GO:0045453 9.46 ACP5 CTSK PTH TNFSF11
32 ossification GO:0001503 9.17 ACP5 BGLAP BMP2 RUNX2 SOST TNFRSF11A

Molecular functions related to Bone Resorption Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA IGF1 PTH

Sources for Bone Resorption Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....