MCID: BNR002
MIFTS: 47

Bone Resorption Disease

Categories: Bone diseases

Aliases & Classifications for Bone Resorption Disease

MalaCards integrated aliases for Bone Resorption Disease:

Name: Bone Resorption Disease 12 15
Bone Resorption 44

Classifications:



External Ids:

Disease Ontology 12 DOID:0080011
MeSH 44 D001862

Summaries for Bone Resorption Disease

Disease Ontology : 12 A bone remodeling disease that results in an abnormal decrease of bone density or mass.

MalaCards based summary : Bone Resorption Disease, also known as bone resorption, is related to osteopetrosis and osteitis fibrosa. An important gene associated with Bone Resorption Disease is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are MicroRNAs in cancer and MicroRNAs in cardiomyocyte hypertrophy. The drugs Adalimumab and Denosumab have been mentioned in the context of this disorder. Affiliated tissues include bone, breast and bone marrow, and related phenotypes are cellular and craniofacial

Wikipedia : 73 Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the... more...

Related Diseases for Bone Resorption Disease

Diseases related to Bone Resorption Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 443)
# Related Disease Score Top Affiliating Genes
1 osteopetrosis 32.5 TNFSF11 RUNX2 NFATC1 LRP5 CTSK CALCA
2 osteitis fibrosa 32.4 PTH CALCA BGLAP
3 multicentric carpotarsal osteolysis syndrome 32.4 TNFSF11 CTSK BGLAP ACP5
4 pycnodysostosis 32.4 TNFSF11 SOST CTSK ACP5
5 paget's disease of bone 32.4 TNFSF11 SOST PTH CALCA BGLAP ACP5
6 bone giant cell tumor 32.3 TNFSF11 PTH CTSK CALCA ACP5
7 paget disease of bone 5, juvenile-onset 32.2 TNFSF11 CALCA
8 glucocorticoid-induced osteoporosis 32.2 TNFSF11 RUNX2 PTH IGF1 CALCA BMP2
9 periodontitis 32.1 TNFSF11 RUNX2 CTSK BGLAP ACP5
10 hyperparathyroidism 31.7 TNFSF11 PTH CALCA BGLAP ACP5
11 osteoporosis 31.6 TNFSF11 SP7 SOST RUNX2 PTH NFATC1
12 mammary paget's disease 31.6 TNFSF11 PTH ESR1 CTSK CALCA BGLAP
13 bone disease 31.6 TNFSF11 SP7 SOST RUNX2 PTH NFATC1
14 secondary hyperparathyroidism 31.4 PTH CALCA BGLAP ACP5
15 osteogenic sarcoma 31.4 TNFSF11 SP7 RUNX2 PTH MIR140 IGF1
16 bone remodeling disease 31.3 TNFSF11 SP7 SOST RUNX2 PTH NFATC1
17 primary hyperparathyroidism 31.3 TNFSF11 SOST PTH IGF1 CALCA BGLAP
18 benign giant cell tumor 31.2 TNFSF11 CTSK CALCA BGLAP
19 hyperthyroidism 31.2 PTH IGF1 CALCA BGLAP ACP5
20 osteomalacia 31.1 PTH CALCA BGLAP
21 insulin-like growth factor i 31.1 IGF1 ESR1 BGLAP
22 osteonecrosis 31.1 TNFSF11 RUNX2 PTH NFATC1 LRP5 IGF1
23 root resorption 31.1 TNFSF11 RUNX2 CTSK CALCA
24 renal osteodystrophy 31.1 TNFSF11 SOST PTH CALCA BGLAP ACP5
25 osteomyelitis 31.0 TNFSF11 NFATC1 CTSK CALCA BMP2 ACP5
26 hypercalcemia, infantile, 1 31.0 PTH CALCA
27 ankylosis 30.9 TNFSF11 SP7 SOST RUNX2 BMP2 BGLAP
28 periapical periodontitis 30.8 TNFSF11 RUNX2 CTSK ACP5
29 exostosis 30.8 SOST CALCA BMP2 BGLAP
30 hypoparathyroidism 30.8 PTH IGF1 CALCA BGLAP
31 hemiplegia 30.8 CALCA BGLAP ACP5
32 spondyloarthropathy 1 30.8 TNFSF11 PTH BGLAP
33 hypervitaminosis d 30.7 PTH CALCA
34 sclerosteosis 30.7 TNFSF11 SP7 SOST RUNX2 PTH LRP5
35 chronic kidney disease 30.7 TNFSF11 SOST RUNX2 PTH IGF1 BGLAP
36 bone cancer 30.6 TNFSF11 PTH MIR140 ESR1 CALCA BMP2
37 scoliosis 30.5 TNFSF11 RUNX2 IGF1 ESR1 CTSK BGLAP
38 osteochondrodysplasia 30.5 TNFSF11 SP7 SOST RUNX2 PTH LRP5
39 brittle bone disorder 30.5 TNFSF11 SP7 SOST RUNX2 PTH LRP5
40 hyperphosphatemia 30.5 RUNX2 PTH BGLAP
41 fibrous dysplasia 30.5 TNFSF11 IGF1 CALCA BGLAP
42 spondylolisthesis 30.5 PTH ESR1 BMP2
43 camurati-engelmann disease 30.4 SP7 RUNX2 LRP5 BGLAP ACP5
44 bone inflammation disease 30.4 TNFSF11 MIR140 ACP5
45 breast adenocarcinoma 30.4 TNFSF11 ESR1 CTSK CALCA BGLAP
46 microphthalmia 30.3 TNFSF11 NFATC1 LRP5 CTSK ACP5
47 ovarian disease 30.2 MIR23A MIR140 IGF1 ESR1
48 heart disease 30.1 NFATC1 MIR23A MIR214 MIR140 IGF1 ESR1
49 diabetes mellitus 30.1 TNFSF11 SOST PTH MIR140 LRP5 IGF1
50 type 2 diabetes mellitus 30.1 TNFSF11 SOST RUNX2 LRP5 IGF1 ESR1

Graphical network of the top 20 diseases related to Bone Resorption Disease:



Diseases related to Bone Resorption Disease

Symptoms & Phenotypes for Bone Resorption Disease

MGI Mouse Phenotypes related to Bone Resorption Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10 BGLAP BMP2 CTSK ESR1 IGF1 LRP5
2 craniofacial MP:0005382 9.7 BMP2 CTSK LRP5 NFATC1 PTH RUNX2
3 limbs/digits/tail MP:0005371 9.7 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
4 skeleton MP:0005390 9.4 BGLAP BMP2 CTSK ESR1 IGF1 LRP5

Drugs & Therapeutics for Bone Resorption Disease

Drugs for Bone Resorption Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 96)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Adalimumab Approved, Experimental Phase 4 331731-18-1 16219006
2
Denosumab Approved Phase 4 615258-40-7
3
Alendronate Approved Phase 4 121268-17-5, 66376-36-1 2088
4
Teriparatide Approved, Investigational Phase 4 52232-67-4 16133850
5
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741
6
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
7 Antirheumatic Agents Phase 4
8 Anti-Inflammatory Agents Phase 4
9 Hormones Phase 4
10 Micronutrients Phase 4
11 Trace Elements Phase 4
12 Nutrients Phase 4
13 Vitamins Phase 4
14 Calciferol Phase 4
15 Diphosphonates Phase 4
16 Ibandronic Acid Phase 4
17
Abaloparatide Approved, Investigational Phase 3 247062-33-5
18
Zoledronic Acid Approved Phase 3 118072-93-8 68740
19
Risedronate Approved, Investigational Phase 3 105462-24-6 5245
20 Anesthetics Phase 3
21 Liver Extracts Phase 2, Phase 3
22 Immunoglobulins Phase 3
23 Antibodies Phase 3
24 Antibodies, Monoclonal Phase 3
25 glucocorticoids Phase 3
26
Parathyroid hormone Approved, Investigational Phase 1, Phase 2 9002-64-6
27
Simvastatin Approved Phase 2 79902-63-9 54454
28
Pamidronate Approved Phase 2 40391-99-9 4674
29
Ipilimumab Approved Phase 1, Phase 2 477202-00-9
30
nivolumab Approved Phase 1, Phase 2 946414-94-4
31
Vitamin D3 Approved, Nutraceutical Phase 2 67-97-0 6221 5280795
32
Ergocalciferol Approved, Nutraceutical Phase 2 50-14-6 5280793
33
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057
34
Saracatinib Investigational Phase 2 379231-04-6
35 Whey Protein Phase 1, Phase 2
36 Anticholesteremic Agents Phase 2
37 Antimetabolites Phase 2
38 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
39 Hypolipidemic Agents Phase 2
40 Lipid Regulating Agents Phase 2
41 Vitamin D2 Phase 2
42 Ergocalciferols Phase 2
43 Antineoplastic Agents, Immunological Phase 1, Phase 2
44 Interferon-gamma Phase 1, Phase 2
45 Immunoglobulins, Intravenous Phase 1, Phase 2
46 Paraproteins Phase 1, Phase 2
47 Myeloma Proteins Phase 1, Phase 2
48 interferons Phase 1, Phase 2
49 Androgens Phase 2
50 Androgen Antagonists Phase 2

Interventional clinical trials:

(show top 50) (show all 116)
# Name Status NCT ID Phase Drugs
1 Bone Resorption, Osteoclastogenesis and Adalimumab Unknown status NCT02035800 Phase 4 Adalimumab
2 A Method for Measuring Volume Changes of the Alveolar Ridge During Dental Implantation Using 3D Scanning Unknown status NCT03089619 Phase 4 Human-Spongiosa
3 Evaluation of Anterior Alveolar Ridge Reconstruction With Allogenic Bone Plate and Autogenous Cortical Bone Chips: A Radiographic and Histological Clinical Study Completed NCT04324697 Phase 4
4 The Efficacy of Denosumab in Decreasing Periprosthetic Bone Loss in Patients With Total Knee Arthroplasty: A Randomised, Double Blind, Placebo Controlled Clinical Trial Completed NCT02760979 Phase 4 Denosumab;Placebo
5 Acute Effect of Teriparatide With Bisphosphonate or Denosumab on Bone Resorption Completed NCT01750086 Phase 4 Teriparatide 40-mcg subcutaneous injection;Denosumab Injection;Alendronate Oral Tablet
6 A Randomized, Double-blind, Placebo-controlled Study to Determine Time to Onset of Suppression of the Bone Resorption Marker sCTX With Once Monthly Ibandronate in the Treatment of Postmenopausal Osteoporosis Completed NCT00303485 Phase 4 Placebo;Vitamin D and calcium supplementation;ibandronate [Bonviva/Boniva]
7 Effects of 1% Sodium Alendronate in Non Surgical Periodontal Therapy on Clinical and Tomographical Parameters: a Randomized Placebo Controlled 6-month Clinical Trial Completed NCT02470611 Phase 4 Sodium alendronate
8 Hyaluronic Acid Effect on Xenogenic Bone Substitutes Healing During Ridge Preservations: A Radiological and Histomorphometric Study Recruiting NCT04377256 Phase 4
9 An Extension Study to Evaluate 24 Months of Standard-of-Care Osteoporosis Management Following Completion of 18 Months of BA058 or Placebo Treatment in Protocol BA058-05-003 Completed NCT01657162 Phase 3 Alendronate
10 Study to Assess Efficacy and Safety of Zoledronic Acid and the Value of Markers of Bone Resorption in the Prediction of Bone Metastases and Cancer Treatment-induced Bone Loss (CTIBL) in Patients With Prostate Cancer on Hormone Therapy Completed NCT00172055 Phase 3 Zoledronic acid
11 COMPARATIVE EVALUATION OF BIOACTIVE GLASS PUTTY AND PLATELET RICH FIBRIN IN THE TREATMENT OF HUMAN PERIODONTAL INTRABONY DEFECTS- A CLINICAL AND RADIOGRAPHICAL STUDY" Completed NCT02982681 Phase 3 Platelet rich fibrin;Bioactive Glass
12 Zoledronic Acid Versus Alendronate for Prevention of Bone Loss After Organ Transplantation Completed NCT00297830 Phase 2, Phase 3 Zoledronic acid;Alendronate
13 Efficacy of Denosumab and Zoledronic Acid in the Treatment of Idiopathic Inflammatory Myopathies Related Reduced Bone Mineral Density: a Prospective Controlled Trial Not yet recruiting NCT04034199 Phase 3 Denosumab;Zoledronic Acid
14 A Randomized, Open-label Therapeutic Trial Evaluating the Efficacy and Safety of Neridronate (Nerixia®) in the Treatment of Osteoporosis in Patients With Thalassemia Major and Severe Thalassemia Intermedia. Completed NCT01140321 Phase 2 Neridronate
15 Impact of a Protein Supplement on Bone Mass in Older Men and Women Completed NCT00421408 Phase 1, Phase 2
16 Teh Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) Wif Alendronate in Teh Preservation of Teh Tooth Socket Completed NCT03980847 Phase 2 Alendronate 20 mg
17 Pilot Study to Evaluate the Effect of Zoledronic Acid (Zometa) on Occult Malignant Bone Marrow Cells in Patients With High Risk Early Stage Breast Cancer Completed NCT00295867 Phase 2 Zoledronic Acid
18 A Phase II, Randomised, Open-Label, Pilot Study to Evaluate the Safety and Effects on Bone Resorption of AZD0530 in Patients With Prostate Cancer or Breast Cancer With Metastatic Bone Disease. Completed NCT00558272 Phase 2 AZD0530;Zoledronic Acid
19 Proof of Concept (Bone Resorption/Bone Mineral Density) Study (0429-005) Completed NCT00533650 Phase 2 MK0429
20 The Effect Of Lasofoxifene On Local Mediators Of Bone Resorption In The Prevention Of Postmenopausal Osteoporosis Completed NCT00674453 Phase 2 Lasofoxifene
21 Restoration of Immediate Peri-implant Defect by Simvastatin: a Controlled Clinical and Cone Beam Computed Tomography Study Completed NCT04803500 Phase 2 Simvastatin;Placebo
22 Prevention of Bone Loss After Pediatric Hematopoietic Cell Transplantation Recruiting NCT02074631 Phase 2 Pamidronate;Calcium and vitamin D
23 Bone Quality and Quantity in the Maxillary Sinus Grafted With Xenograft or Synthetic Bone Substitute: A Radiographic and Histomorphometric Randomized Controlled Clinical Study Recruiting NCT04433117 Phase 2
24 A Randomized, Double-blind and Imitation, Parallel-control, Multicenter Phase II Study of AL2846 Versus Zoledronic Acid in Subjects With Advanced Non-small Cell Lung Cancer (NSCLC) With Bone Metastasis Recruiting NCT04325776 Phase 2 AL2846;Zoledronic Acid Injection
25 A Phase Ib/II Trial of Ipilimumab-Nivolumab-Denosumab and Nivolumab-Denosumab in Patients With Unresectable Stage III and IV Melanoma Recruiting NCT03161756 Phase 1, Phase 2 Denosumab;Nivolumab;Ipilimumab
26 Feasibility of Bisphosphonate Use on Sleeve Gastrectomy Associated Bone Loss: Healthy Body, Healthy Bones Trial Recruiting NCT04279392 Phase 1, Phase 2 Zoledronic Acid 5 mg/Bag 100 ml Inj;Placebos
27 A Phase II Study of Denosumab in Combination With Enzalutamide in Progressive Metastatic Castrate-resistant Prostate Cancer and Bone Metastases. Suspended NCT03869762 Phase 2 Xgeva;Xtandi
28 A Phase I/II Randomized, Double-blind, Controlled Study to Evaluate Efficacy and Safety of Vitamin D on Bone Mineral Density and Markers of Bone Resorption in Aromatase Inhibitor-induced Bone Loss in Women With Breast Cancer. Terminated NCT00904423 Phase 1, Phase 2 Vitamin D
29 Phase I Trial of Evaluating the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Fully Human Monoclonal Antibody to RANKL (TK006) in Post-menopausal Women. Unknown status NCT03242512 Phase 1
30 Health of Young European Families and Fish Consumption Unknown status NCT00315770 Phase 1
31 Effect of Soy Bread on Markers of Bone Metabolism and Cardiovascular Disease Completed NCT00366860 Phase 1
32 Evaluation of Efficacy of Injectable Platelet-Rich Plasma (PRP) in Reducing Alveolar Bone Resorption Following Rapid Maxillary Expansion (RME): A Cone Beam Computed Tomography (CBCT) Assessment Completed NCT03028038 Phase 1 Platelet Rich Plasma;No Platelet Rich Plasma
33 A Double-Blind, Placebo-Controlled, Once-Weekly, Multiple-Dose Study to Investigate the Safety, Tolerability, Plasma Concentration Profile and Effects on Biochemical Markers of Bone Resorption of MK0822 in Healthy Postmenopausal Female Subjects Completed NCT00770159 Phase 1 odanacatib;Comparator: placebo to MK0822
34 Anti-Osteoclast Therapy as Neoadjuvant in Treatment of Chondrosarcoma - Phase 1b Trial Recruiting NCT03173976 Phase 1 Zoledronic Acid
35 A Prospective, Randomized-controlled Study of the Effect of a Chlorhexidine Based Gel on the Internal Implant Surface Treatment on the Reduction of Bacterial Load and on the Regressive Bone Modelling. Unknown status NCT03431766
36 3D Printed Scaffold Device for Ridge Preservation After Tooth Extraction - A Randomised Controlled Clinical Trial Unknown status NCT03735199
37 Alveolar Ridge Preservation in Mandibular Molars Using Mixture of Autogenous Bone & Anorganic Bovine Bone (ABB) Versus Anorganic Bovine Bone Alone Versus Absorbent Gelatin Sponge Unknown status NCT03584984
38 Posterior Maxillary Ridge Augmentation With Sinus Lift Using Mineralized Plasmatic Matrix Versus Autogenous Bone Graft (A Randomized Clinical Trial Comparative Study) Unknown status NCT03014388
39 Implant Insertion in Defective Anterior Maxillary Ridge Augmented Using Mineralized Plasmatic Matrix Versus Autogenous Bone Graft Unknown status NCT03007069
40 Clinical Evaluation Of Dental Implants Stability Placed In Healed Bony Sites Following Over-drilling Compared To Conventional-Drilling Protocol: A Randomized Controlled Trial. Unknown status NCT03250949
41 Clinical Evaluation of the Effect of Low Speed Drilling Versus Conventional Drilling Technique on Crestal Bone Level in Maxilla. A Randomized Controlled Clinical Trial Unknown status NCT03220815
42 Clinical Evaluation of the Effect of Low Speed Drilling Versus Conventional Drilling Technique on Crestal Bone Level in Maxilla. A Randomized Controlled Clinical Trial Unknown status NCT03220789
43 Clinical Evaluation of the Effect of Low Speed Drilling Versus Conventional Drilling Technique on Crestal Bone Level in Maxilla. A Randomized Controlled Clinical Trial Unknown status NCT03212820
44 Evaluation of Computer-Guided Versus Conventional Simultaneous Implant Placement With Ridge Augmentation Using an Autogenous Bone Ring Graft With PRF on Patient's Esthetic Satisfaction Unknown status NCT03049137 Platelet-rich fibrin (PRF)
45 Clinical Assessment of Buccal Plate Expansion Technique Versus Guided Bone Regeneration Technique in Socket Preservation in The Esthetic Zone: A Randomized Controlled Clinical Trial Unknown status NCT03065803
46 Assessment of Vertical Bone Augmentation Using Autogenous Onlay Versus Inlay Grafting Techniques With Simultaneous Implant Placement in the Anterior Maxillary Area on Patient's Esthetic Satisfaction : A Randomized Clinical Trial Unknown status NCT03052387
47 Role of Light Emitting Diode on Implant Stability, Bone Resorption and Analgesia Post Dental Implant Placement Unknown status NCT01097499
48 Influence of Superstructure Material on Crestal Bone Resorption and Esthetic Outcome of Dental Implants Unknown status NCT02937220
49 Immediate Dentoalveolar Restoration Compared to Demineralized Bovine Bone in Immediate Implants Placed in Fresh Sockets With Buccal Bone Resorption: 18-months Randomized Controlled Trial Unknown status NCT03202030
50 Socket Shield Technique Versus Conventional Immediate Implant Placement in Thin Buccofacial Bone to Evaluate Buccal Bone Resorption: A Randomized Controlled Trial Unknown status NCT03264053

Search NIH Clinical Center for Bone Resorption Disease

Cochrane evidence based reviews: bone resorption

Genetic Tests for Bone Resorption Disease

Anatomical Context for Bone Resorption Disease

MalaCards organs/tissues related to Bone Resorption Disease:

40
Bone, Breast, Bone Marrow, Prostate, Kidney, Thyroid, Monocytes

Publications for Bone Resorption Disease

Articles related to Bone Resorption Disease:

(show top 50) (show all 25919)
# Title Authors PMID Year
1
Guizhi-Shaoyao-Zhimu decoction attenuates bone erosion in rats that have collagen-induced arthritis via modulating NF-κB signalling to suppress osteoclastogenesis. 61
33626293 2021
2
Lithium chloride promotes osteogenesis and suppresses apoptosis during orthodontic tooth movement in osteoporotic model via regulating autophagy. 61
33778189 2021
3
Synergistic effects of magnesium ions and simvastatin on attenuation of high-fat diet-induced bone loss. 61
33665494 2021
4
The molecular structure and function of sorting nexin 10 in skeletal disorders, cancers, and other pathological conditions. 61
33241559 2021
5
Prediction of Fracture Risk From Early-Stage Bone Markers in Patients With Osteoporosis Treated With Once-Yearly Administered Zoledronic Acid. 61
33135182 2021
6
Negative pressure wound therapy enhances bone regeneration compared with conventional therapy in a rabbit radius gap-healing model. 61
33767769 2021
7
β-Catenin signaling is important for osteogenesis and hematopoiesis recovery following methotrexate chemotherapy in rats. 61
33078406 2021
8
Reference intervals in Danish children and adolescents for bone turnover markers carboxy-terminal cross-linked telopeptide of type I collagen (β-CTX), pro-collagen type I N-terminal propeptide (PINP), osteocalcin (OC) and bone-specific alkaline phosphatase (bone ALP). 61
33561588 2021
9
Cadmium toxicity: A role in bone cell function and teeth development. 61
33485206 2021
10
An SNX10-dependent mechanism down-regulates fusion between mature osteoclasts. 61
33795396 2021
11
Effects of different splinting times on surgically extruded teeth with a crown-root fracture: A randomized controlled trial. 61
33179388 2021
12
Osteoporosis prevention in an extraordinary hibernating bear. 61
33450432 2021
13
Anti-perimenopausal osteoporosis effects of Erzhi formula via regulation of bone resorption through osteoclast differentiation: A network pharmacology-integrated experimental study. 61
33444724 2021
14
Mineral trioxide aggregate (MTA) inhibits osteoclastogenesis and osteoclast activation through calcium and aluminum activities. 61
32789653 2021
15
Immunoexpression pattern of autophagy mediators in alveolar bone osteoclasts following estrogen withdrawal in female rats. 61
33409945 2021
16
Schistosoma japonicum cystatin suppresses osteoclastogenesis via manipulating the NF‑κB signaling pathway. 61
33576450 2021
17
Demethoxycucumin protects MDA-MB-231 cells induced bone destruction through JNK and ERK pathways inhibition. 61
33403398 2021
18
Bone metabolic marker concentrations across the menstrual cycle and phases of combined oral contraceptive use. 61
33508495 2021
19
Angiotensin II triggers knee joint lesions in experimental osteoarthritis. 61
33422700 2021
20
Trilobatin ameliorates bone loss via suppression of osteoclast cell differentiation and bone resorptive function in vitro and in vivo. 61
33497739 2021
21
Effects of combined use of recombinant human fibroblast growth factor-2 and β-tricalcium phosphate on ridge preservation in dehiscence bone defects after tooth extraction: A split-mouth study in dogs. 61
33314140 2021
22
Effect of Mechanical Strain on Cells Involved in Fracture Healing. 61
33496077 2021
23
Nano-needle strontium-substituted apatite coating enhances osteoporotic osseointegration through promoting osteogenesis and inhibiting osteoclastogenesis. 61
33102935 2021
24
Strontium substituted hydroxyapatite with β-lactam integrin agonists to enhance mesenchymal cells adhesion and to promote bone regeneration. 61
33493943 2021
25
Effects of implant buccal distance on peri-implant strain: A Micro-CT based finite element analysis. 61
33485035 2021
26
A missense mutation sheds light on a novel structure-function relationship of RANKL. 61
32964459 2021
27
Effects of ınjectable platelet-rich fibrin in experimental periodontitis in rats. 61
33068206 2021
28
The role of miR-150 regulates bone cell differentiation and function. 61
32526406 2021
29
Decompressive Craniectomy in Traumatic Brain Injury-Craniectomy-Related and Cranioplasty-Related Complications in a Single Center. 61
33444838 2021
30
3D-printed PEEK implant for mandibular defects repair - a new method. 61
33494021 2021
31
[Facial skin fistula as a postoperative complication of a mandibular guided bone regeneration]. 61
33789418 2021
32
Chlorogenic acid promotes osteogenic differentiation of human dental pulp stem cells via Wnt signaling. 61
33789447 2021
33
Three-year follow-up of bone status in male patients after bariatric surgery-a prospective single-center cohort study. 61
33436310 2021
34
Syndecan-3 enhances anabolic bone formation through WNT signaling. 61
33769615 2021
35
Trem2 mediated Syk-dependent ROS amplification is essential for osteoclastogenesis in periodontitis microenvironment. 61
33486152 2021
36
Static Magnetic Field (2-4 T) Improves Bone Microstructure and Mechanical Properties by Coordinating Osteoblast/Osteoclast Differentiation in Mice. 61
33655538 2021
37
Effect of load-induced local mechanical strain on peri-implant bone cell activity related to bone resorption and formation in mice: An analysis of histology and strain distributions. 61
33545417 2021
38
Osteoclasts recycle via osteomorphs during RANKL-stimulated bone resorption. 61
33798441 2021
39
Influence of photodynamic therapy on the periodontitis-induced bone resorption in rat. 61
32808146 2021
40
Anti-IL17 antibody Secukinumab therapy is associated with ossification in giant cell tumor of bone: a case report of pathologic similarities and therapeutic potential similar to Denosumab. 61
33794838 2021
41
Kaiso regulates osteoblast differentiation and mineralization via the Itga10/PI3K/AKT signaling pathway. 61
33576467 2021
42
LY3023414 inhibits both osteogenesis and osteoclastogenesis through the PI3K/Akt/GSK3 signalling pathway. 61
33789427 2021
43
Bisphosphonates impair the onset of bone formation at remodeling sites. 61
33465485 2021
44
Osteoblast role in the pathogenesis of rheumatoid arthritis. 61
33774802 2021
45
Cyanidin attenuates IL-17A cytokine signaling mediated monocyte migration and differentiation into mature osteoclasts in rheumatoid arthritis. 61
33810944 2021
46
Effects of systemically administered abaloparatide, an osteoanabolic PTHrP analog, as an adjuvant therapy for spinal fusion in rats. 61
33778406 2021
47
Protocatechualdehyde inhibits receptor activator of nuclear factor kappa-B ligand-induced osteoclastogenesis and attenuates lipopolysaccharide-induced inflammatory osteolysis. 61
33778997 2021
48
Bisphosphonates and management of kidney stones and bone disease. 61
33394731 2021
49
The Pathophysiology of Osteoporosis after Spinal Cord Injury. 61
33802713 2021
50
An Overview of the Molecular Mechanisms Contributing to Musculoskeletal Disorders in Chronic Liver Disease: Osteoporosis, Sarcopenia, and Osteoporotic Sarcopenia. 61
33807573 2021

Variations for Bone Resorption Disease

Expression for Bone Resorption Disease

Search GEO for disease gene expression data for Bone Resorption Disease.

Pathways for Bone Resorption Disease

GO Terms for Bone Resorption Disease

Cellular components related to Bone Resorption Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.4 TNFSF11 SOST PTH MIR335 MIR23A MIR140

Biological processes related to Bone Resorption Disease according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.98 SOST RUNX2 NFATC1 LRP5 IGF1 ESR1
2 gene silencing by miRNA GO:0035195 9.97 MIR335 MIR23A MIR214 MIR188 MIR140 MIR133A1
3 positive regulation of gene expression GO:0010628 9.95 TNFSF11 RUNX2 MIR140 MIR133A1 IGF1 BMP2
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.81 TNFSF11 SP7 RUNX2 PTH NFATC1 LRP5
5 negative regulation of gene expression GO:0010629 9.8 PTH MIR214 MIR140 IGF1 ESR1 BMP2
6 positive regulation of DNA-binding transcription factor activity GO:0051091 9.78 TNFSF11 LRP5 ESR1
7 osteoblast differentiation GO:0001649 9.76 SP7 RUNX2 BMP2 BGLAP
8 bone development GO:0060348 9.71 TNFSF11 LRP5 BGLAP
9 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.69 MIR214 MIR140 MIR133A1
10 positive regulation of osteoblast differentiation GO:0045669 9.67 RUNX2 LRP5 IGF1 BMP2
11 skeletal system development GO:0001501 9.65 RUNX2 PTH IGF1 BMP2 BGLAP
12 mammary gland alveolus development GO:0060749 9.6 TNFSF11 ESR1
13 positive regulation of ossification GO:0045778 9.59 PTH BMP2
14 positive regulation of glycogen biosynthetic process GO:0045725 9.58 PTH IGF1
15 regulation of osteoclast differentiation GO:0045670 9.58 TNFSF11 BGLAP
16 osteoblast development GO:0002076 9.58 RUNX2 LRP5 BGLAP
17 positive regulation of osteoblast proliferation GO:0033690 9.57 LRP5 BMP2
18 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.56 RUNX2 BMP2
19 bone mineralization involved in bone maturation GO:0035630 9.55 IGF1 BMP2
20 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.52 RUNX2 BMP2
21 bone resorption GO:0045453 9.26 TNFSF11 PTH CTSK ACP5
22 ossification GO:0001503 9.1 TNFSF11 SOST RUNX2 BMP2 BGLAP ACP5

Molecular functions related to Bone Resorption Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.02 MIR23A MIR214 MIR188 MIR140 MIR133A1

Sources for Bone Resorption Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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