MCID: BNR002
MIFTS: 32

Bone Resorption Disease

Categories: Bone diseases

Aliases & Classifications for Bone Resorption Disease

MalaCards integrated aliases for Bone Resorption Disease:

Name: Bone Resorption Disease 12 15
Bone Resorption 44

Classifications:



External Ids:

Disease Ontology 12 DOID:0080011
MeSH 44 D001862

Summaries for Bone Resorption Disease

Disease Ontology : 12 A bone remodeling disease that results in an abnormal decrease of bone density or mass.

MalaCards based summary : Bone Resorption Disease, also known as bone resorption, is related to osteitis fibrosa and osteoporosis. An important gene associated with Bone Resorption Disease is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and RANK Signaling in Osteoclasts. Affiliated tissues include bone, and related phenotypes are cellular and growth/size/body region

Wikipedia : 76 Bone reabsorption is resorption of bone tissue, that is, the process by which osteoclasts break down the... more...

Related Diseases for Bone Resorption Disease

Diseases related to Bone Resorption Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 osteitis fibrosa 32.7 BGLAP CALCA PTH
2 osteoporosis 27.0 ACP5 BGLAP BMP2 CALCA CTSK ESR1
3 axial osteomalacia 11.0 BGLAP PTH
4 extraskeletal chondroma 11.0 BGLAP PTH
5 fibrogenesis imperfecta ossium 10.9 CALCA PTH TNFRSF11B
6 osteopetrosis, autosomal dominant 2 10.9 BGLAP TNFSF11
7 kummell's disease 10.9 SOST TNFRSF11B TNFSF11
8 hypophosphatasia, adult 10.9 BGLAP CALCA PTH
9 impaired renal function disease 10.9 BGLAP PTH SOST
10 multicentric reticulohistiocytosis 10.9 TNFRSF11B TNFSF11
11 sclerosteosis 1 10.9 SOST SP7
12 villonodular synovitis 10.9 ACP5 TNFSF11
13 hypercalcemia, infantile, 1 10.8 CALCA PTH VDR
14 breast leiomyosarcoma 10.8 TNFRSF11A TNFSF11
15 polyarticular onset juvenile idiopathic arthritis 10.8 TNFRSF11A TNFRSF11B TNFSF11
16 bone giant cell tumor 10.8 ACP5 CALCA CTSK
17 idiopathic hypercalciuria 10.8 BGLAP TNFSF11 VDR
18 hemophilic arthropathy 10.8 TNFRSF11A TNFRSF11B TNFSF11
19 familial expansile osteolysis 10.8 TNFRSF11A TNFRSF11B TNFSF11
20 periodontitis, chronic 10.8 TNFRSF11B TNFSF11
21 mineral metabolism disease 10.8 CALCA PTH VDR
22 aneurysmal bone cysts 10.8 CALCA TNFRSF11A TNFSF11
23 osteomalacia 10.8 BGLAP CALCA VDR
24 chronic apical periodontitis 10.8 TNFRSF11B TNFSF11
25 osteogenesis imperfecta, type vi 10.8 SOST SP7 TNFSF11
26 osteoporotic fracture 10.8 ESR1 TNFRSF11B
27 osseous heteroplasia, progressive 10.8 BGLAP BMP2 RUNX2
28 protrusio acetabuli 10.8 ESR1 VDR
29 ossification of the posterior longitudinal ligament of spine 10.8 BGLAP BMP2 RUNX2
30 craniodiaphyseal dysplasia 10.8 CALCA LRP5 SOST
31 camurati-engelmann disease 10.7 ACP5 BGLAP LRP5
32 hyperphosphatemia 10.7 PTH RUNX2 VDR
33 uremia 10.7 PTH TNFRSF11B VDR
34 fibrous dysplasia 10.7 BGLAP CALCA IGF1
35 parathyroid gland disease 10.7 BGLAP CALCA PTH VDR
36 parathyroid adenoma 10.7 BGLAP CALCA PTH VDR
37 thyroid gland disease 10.7 CALCA IGF1 PTH
38 aortic valve disease 1 10.7 BMP2 RUNX2 TNFRSF11B
39 rickets 10.7 BGLAP PTH VDR
40 pfeiffer syndrome 10.7 BGLAP RUNX2 SP7
41 primary hyperparathyroidism 10.7 BGLAP CALCA PTH VDR
42 osteogenesis imperfecta, type i 10.7 BGLAP IGF1 TNFRSF11B
43 tooth ankylosis 10.7 BMP2 TNFSF11
44 bone fracture 10.7 BGLAP BMP2 LRP5
45 van buchem disease 10.7 LRP5 SOST VDR
46 spondylosis 10.7 ESR1 PTH VDR
47 paget disease of bone 5, juvenile-onset 10.6 CALCA TNFRSF11A TNFRSF11B TNFSF11
48 mouth disease 10.6 TNFSF11 TRPV1 VDR
49 hypervitaminosis d 10.6 PTH VDR
50 periapical periodontitis 10.6 ACP5 TNFRSF11A TNFRSF11B TNFSF11

Graphical network of the top 20 diseases related to Bone Resorption Disease:



Diseases related to Bone Resorption Disease

Symptoms & Phenotypes for Bone Resorption Disease

MGI Mouse Phenotypes related to Bone Resorption Disease:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.41 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
2 growth/size/body region MP:0005378 10.35 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
3 cardiovascular system MP:0005385 10.29 BMP2 ESR1 IGF1 LRP5 NFATC1 PTH
4 homeostasis/metabolism MP:0005376 10.28 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
5 immune system MP:0005387 10.25 IGF1 LRP5 NFATC1 PTH RPL24 RUNX2
6 hematopoietic system MP:0005397 10.23 IGF1 LRP5 NFATC1 PTH RUNX2 TNFRSF11A
7 craniofacial MP:0005382 10.22 BMP2 CTSK LRP5 NFATC1 PTH RUNX2
8 limbs/digits/tail MP:0005371 10.2 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
9 endocrine/exocrine gland MP:0005379 10.15 TNFSF11 VDR CTSK ESR1 IGF1 LRP5
10 mortality/aging MP:0010768 10.07 BMP2 ESR1 IGF1 LRP5 NFATC1 PTH
11 digestive/alimentary MP:0005381 10.05 BMP2 CTSK ESR1 NFATC1 RUNX2 TNFRSF11A
12 integument MP:0010771 10.02 VDR ESR1 IGF1 NFATC1 RPL24 RUNX2
13 neoplasm MP:0002006 9.63 ESR1 IGF1 RPL24 TNFRSF11A TNFSF11 TRPV1
14 respiratory system MP:0005388 9.56 CTSK ESR1 IGF1 NFATC1 RUNX2 SP7
15 skeleton MP:0005390 9.5 CTSK ESR1 IGF1 LRP5 NFATC1 PTH

Drugs & Therapeutics for Bone Resorption Disease

Search Clinical Trials , NIH Clinical Center for Bone Resorption Disease

Cochrane evidence based reviews: bone resorption

Genetic Tests for Bone Resorption Disease

Anatomical Context for Bone Resorption Disease

MalaCards organs/tissues related to Bone Resorption Disease:

41
Bone

Publications for Bone Resorption Disease

Articles related to Bone Resorption Disease:

# Title Authors Year
1
[The OPG/RANKL/RANK system and bone resorptive disease]. ( 15971575 )
2003

Variations for Bone Resorption Disease

Expression for Bone Resorption Disease

Search GEO for disease gene expression data for Bone Resorption Disease.

Pathways for Bone Resorption Disease

GO Terms for Bone Resorption Disease

Cellular components related to Bone Resorption Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 BGLAP BMP2 CALCA CTSK IGF1 PTH
2 extracellular space GO:0005615 9.28 BGLAP BMP2 CALCA CTSK IGF1 PTH

Biological processes related to Bone Resorption Disease according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 regulation of apoptotic process GO:0042981 9.96 BMP2 ESR1 LRP5 TNFRSF11A TNFRSF11B
2 regulation of signaling receptor activity GO:0010469 9.93 BMP2 CALCA IGF1 PTH TNFRSF11B TNFSF11
3 positive regulation of transcription, DNA-templated GO:0045893 9.91 BMP2 ESR1 IGF1 LRP5 NFATC1 RUNX2
4 positive regulation of transcription by RNA polymerase II GO:0045944 9.85 BMP2 ESR1 IGF1 LRP5 NFATC1 PTH
5 cellular calcium ion homeostasis GO:0006874 9.83 CALCA PTH VDR
6 positive regulation of DNA binding transcription factor activity GO:0051091 9.83 ESR1 LRP5 TNFRSF11A TNFSF11
7 osteoblast differentiation GO:0001649 9.81 BGLAP BMP2 RUNX2 SP7
8 response to estrogen GO:0043627 9.8 BGLAP ESR1 TNFRSF11B
9 response to nutrient levels GO:0031667 9.8 BGLAP IGF1 PTH
10 positive regulation of osteoblast differentiation GO:0045669 9.79 BMP2 IGF1 RUNX2
11 bone development GO:0060348 9.78 BGLAP LRP5 TNFSF11
12 cellular response to growth factor stimulus GO:0071363 9.77 BGLAP BMP2 TRPV1
13 response to heat GO:0009408 9.75 CALCA IGF1 TRPV1
14 monocyte chemotaxis GO:0002548 9.74 CALCA TNFRSF11A TNFSF11
15 positive regulation of bone resorption GO:0045780 9.67 TNFRSF11A TNFSF11
16 regulation of osteoclast differentiation GO:0045670 9.67 BGLAP TNFSF11
17 positive regulation of glycogen biosynthetic process GO:0045725 9.66 IGF1 PTH
18 response to inorganic substance GO:0010035 9.65 BGLAP TNFRSF11B
19 regulation of ossification GO:0030278 9.65 LRP5 RUNX2
20 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.65 CALCA TRPV1
21 negative regulation of bone resorption GO:0045779 9.64 CALCA TNFRSF11B
22 positive regulation of osteoblast proliferation GO:0033690 9.64 BMP2 LRP5
23 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.63 BMP2 RUNX2
24 osteoblast development GO:0002076 9.61 BGLAP LRP5 RUNX2
25 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.59 BMP2 RUNX2
26 bone mineralization involved in bone maturation GO:0035630 9.58 BMP2 IGF1
27 mammary gland alveolus development GO:0060749 9.58 ESR1 TNFRSF11A TNFSF11
28 bone resorption GO:0045453 9.56 ACP5 CTSK PTH TNFSF11
29 TNFSF11-mediated signaling pathway GO:0071847 9.55 TNFRSF11A TNFSF11
30 mammary gland branching involved in pregnancy GO:0060745 9.54 ESR1 VDR
31 positive regulation of ossification GO:0045778 9.5 BMP2 CALCA PTH
32 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.49 TNFRSF11A TNFSF11
33 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.48 TNFRSF11A TNFSF11
34 ossification GO:0001503 9.43 BGLAP BMP2 RUNX2 SOST TNFRSF11A TNFSF11
35 skeletal system development GO:0001501 9.17 BGLAP BMP2 IGF1 PTH RUNX2 TNFRSF11B
36 inflammatory response GO:0006954 10.02 BMP2 CALCA TNFRSF11A TNFRSF11B TRPV1

Molecular functions related to Bone Resorption Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA IGF1 PTH

Sources for Bone Resorption Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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