MCID: BNR002
MIFTS: 53

Bone Resorption Disease

Categories: Bone diseases

Aliases & Classifications for Bone Resorption Disease

MalaCards integrated aliases for Bone Resorption Disease:

Name: Bone Resorption Disease 12 15
Bone Resorption 44

Classifications:



External Ids:

Disease Ontology 12 DOID:0080011
MeSH 44 D001862

Summaries for Bone Resorption Disease

Disease Ontology : 12 A bone remodeling disease that results in an abnormal decrease of bone density or mass.

MalaCards based summary : Bone Resorption Disease, also known as bone resorption, is related to osteopetrosis and osteitis fibrosa. An important gene associated with Bone Resorption Disease is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are Development Endothelin-1/EDNRA signaling and RANK Signaling in Osteoclasts. Affiliated tissues include bone, prostate and t cells, and related phenotypes are cellular and growth/size/body region

Wikipedia : 76 Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the... more...

Related Diseases for Bone Resorption Disease

Diseases related to Bone Resorption Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 203)
# Related Disease Score Top Affiliating Genes
1 osteopetrosis 32.3 CTSK LRP5 TNFRSF11A TNFSF11
2 osteitis fibrosa 32.0 BGLAP CALCA PTH
3 paget disease of bone 5, juvenile-onset 31.8 CALCA TNFRSF11A TNFRSF11B TNFSF11
4 glucocorticoid-induced osteoporosis 31.8 ACP5 BGLAP BMP2 CALCA IGF1 PTH
5 periodontitis 31.0 BGLAP CTSK RUNX2 TNFRSF11B TNFSF11
6 periodontal disease 30.8 TNFRSF11A TNFRSF11B TNFSF11
7 rheumatoid arthritis 30.8 ACP5 CTSK TNFRSF11A TNFRSF11B TNFSF11
8 giant cell tumor 30.5 BGLAP CALCA CTSK TNFRSF11A TNFRSF11B TNFSF11
9 hyperparathyroidism 30.5 ACP5 BGLAP CALCA PTH TNFRSF11B VDR
10 periapical periodontitis 30.5 ACP5 TNFRSF11A TNFRSF11B TNFSF11
11 osteoporotic fracture 30.4 ESR1 TNFRSF11B
12 idiopathic hypercalciuria 30.4 BGLAP TNFSF11 VDR
13 bone giant cell tumor 30.3 ACP5 CALCA CTSK TNFSF11
14 primary hyperparathyroidism 30.3 BGLAP CALCA PTH VDR
15 secondary hyperparathyroidism of renal origin 30.2 ACP5 BGLAP CALCA PTH TNFRSF11B VDR
16 paget's disease of bone 30.2 ACP5 BGLAP CALCA PTH TNFRSF11A TNFRSF11B
17 uremia 30.2 PTH TNFRSF11B VDR
18 osteonecrosis 30.2 ACP5 BGLAP BMP2 PTH RUNX2 TNFRSF11B
19 osteoporosis 30.2 ACP5 BGLAP BMP2 CALCA CTSK ESR1
20 renal osteodystrophy 30.1 BGLAP CALCA PTH SOST TNFRSF11B VDR
21 multicentric reticulohistiocytosis 30.0 TNFRSF11B TNFSF11
22 hemophilic arthropathy 30.0 TNFRSF11A TNFRSF11B TNFSF11
23 bone inflammation disease 30.0 ACP5 BGLAP CTSK TNFRSF11B TNFSF11 TRPV1
24 osteogenesis imperfecta, type i 30.0 BGLAP IGF1 TNFRSF11B
25 root resorption 30.0 CALCA CTSK RUNX2 TNFRSF11A TNFRSF11B TNFSF11
26 hypervitaminosis d 29.9 PTH VDR
27 chronic kidney failure 29.9 BGLAP CALCA IGF1 PTH TNFRSF11B VDR
28 rickets 29.9 BGLAP PTH VDR
29 breast adenocarcinoma 29.9 CALCA CTSK ESR1 TNFSF11
30 bone cancer 29.8 ESR1 TNFRSF11A TNFSF11 TRPV1
31 bone remodeling disease 29.8 ACP5 BGLAP BMP2 CALCA CTSK ESR1
32 calciphylaxis 29.7 PTH VDR
33 bone disease 29.5 ACP5 BGLAP CALCA CTSK IGF1 LRP5
34 hajdu-cheney syndrome 11.0
35 failure of tooth eruption, primary 11.0
36 paget disease of bone 3 11.0
37 singleton-merten syndrome 1 11.0
38 osteopetrosis, autosomal recessive 5 11.0
39 paget disease of bone 2, early-onset 11.0
40 osteopetrosis, autosomal dominant 1 11.0
41 osteopetrosis, autosomal recessive 8 11.0
42 hyperparathyroidism 4 11.0
43 ameloblastic carcinoma 11.0
44 arthritis 10.5
45 axial osteomalacia 10.3 BGLAP PTH
46 extraskeletal chondroma 10.3 BGLAP PTH
47 myeloma, multiple 10.3
48 osteoarthritis 10.3
49 pseudoarthrosis 10.3 BMP2 PTH
50 fibrogenesis imperfecta ossium 10.3 CALCA PTH TNFRSF11B

Graphical network of the top 20 diseases related to Bone Resorption Disease:



Diseases related to Bone Resorption Disease

Symptoms & Phenotypes for Bone Resorption Disease

MGI Mouse Phenotypes related to Bone Resorption Disease:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.41 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
2 growth/size/body region MP:0005378 10.35 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
3 cardiovascular system MP:0005385 10.29 BMP2 ESR1 IGF1 LRP5 NFATC1 PTH
4 homeostasis/metabolism MP:0005376 10.28 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
5 immune system MP:0005387 10.25 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
6 hematopoietic system MP:0005397 10.23 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
7 craniofacial MP:0005382 10.22 BMP2 CTSK LRP5 NFATC1 PTH RUNX2
8 limbs/digits/tail MP:0005371 10.2 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1
9 endocrine/exocrine gland MP:0005379 10.15 CTSK ESR1 IGF1 LRP5 PTH RUNX2
10 mortality/aging MP:0010768 10.07 BMP2 ESR1 IGF1 LRP5 NFATC1 PTH
11 digestive/alimentary MP:0005381 10.05 BMP2 CTSK ESR1 NFATC1 RUNX2 TNFRSF11A
12 integument MP:0010771 10.02 ESR1 IGF1 NFATC1 RPL24 RUNX2 TNFRSF11A
13 neoplasm MP:0002006 9.63 ESR1 IGF1 RPL24 TNFRSF11A TNFSF11 TRPV1
14 respiratory system MP:0005388 9.56 CTSK ESR1 IGF1 NFATC1 RUNX2 SP7
15 skeleton MP:0005390 9.5 BMP2 CTSK ESR1 IGF1 LRP5 NFATC1

Drugs & Therapeutics for Bone Resorption Disease

Search Clinical Trials , NIH Clinical Center for Bone Resorption Disease

Cochrane evidence based reviews: bone resorption

Genetic Tests for Bone Resorption Disease

Anatomical Context for Bone Resorption Disease

MalaCards organs/tissues related to Bone Resorption Disease:

41
Bone, Prostate, T Cells, Spinal Cord, Lung, Kidney, Liver

Publications for Bone Resorption Disease

Articles related to Bone Resorption Disease:

(show top 50) (show all 1386)
# Title Authors Year
1
LncRNA AK077216 promotes RANKL-induced osteoclastogenesis and bone resorption via NFATc1 by inhibition of NIP45. ( 30132869 )
2019
2
Conditioned fear stress increases bone resorption in apical periodontitislesions in Wistar male rats. ( 30339914 )
2019
3
Relation of RANKL and OPG Levels with Bone Resorption in Patients with Acromegaly and Prolactinoma. ( 29895074 )
2018
4
Effects on bone resorption markers of continuing pamidronate or switching to zoledronic acid in patients with high risk bone metastases from breast cancer. ( 29204337 )
2018
5
Medication-related osteonecrosis of the jaw incidence in patients exposed concomitantly to bone resorption inhibitors and vascular endothelial growth factor receptor tyrosine kinase inhibitors: is it generalizable to all solid tumors? ( 29860712 )
2018
6
Sclerostin Antibody Reverses Bone Loss by Increasing Bone Formation and Decreasing Bone Resorption in a Rat Model of Male Osteoporosis. ( 29069393 )
2018
7
Multiple subperiosteal bone resorption in adult T-cell leukemia/lymphoma. ( 30190354 )
2018
8
Targeted delivery of p-coumaric acid encapsulated mannosylated liposomes to the synovial macrophages inhibits osteoclast formation and bone resorption in the rheumatoid arthritis animal model. ( 30339889 )
2018
9
Increased bone resorption in hemophilia. ( 29857920 )
2018
10
Subchondral fracture begins from the bone resorption area in osteonecrosis of the femoral head: a micro-computerised tomography study. ( 29541811 )
2018
11
Incidence of medication-related osteonecrosis of the jaw in patients treated with both bone resorption inhibitors and vascular endothelial growth factor receptor tyrosine kinase inhibitors. ( 28963584 )
2018
12
Small molecule inhibitor RepSox prevented ovariectomy-induced osteoporosis by suppressing osteoclast differentiation and bone resorption. ( 30059597 )
2018
13
Hydroxysafflor Yellow A Promoted Bone Mineralization and Inhibited Bone Resorption Which Reversed Glucocorticoids-Induced Osteoporosis. ( 30069475 )
2018
14
Modeling and simulation of bone mineral density in Japanese osteoporosis patients treated with zoledronic acid using tartrate-resistant acid phosphatase 5b, a bone resorption marker. ( 29423715 )
2018
15
Bu-Shen-Tong-Luo decoction prevents bone loss via inhibition of bone resorption and enhancement of angiogenesis in ovariectomy-induced osteoporosis of rats. ( 29317302 )
2018
16
Bis‑enoxacin blocks alveolar bone resorption in rats with ovariectomy‑induced osteoporosis. ( 29257280 )
2018
17
Effects of Cynanchum wilfordii on osteoporosis with inhibition of bone resorption and induction of bone formation. ( 29257324 )
2018
18
Long-term testosterone depletion attenuates inflammatory bone resorption in the ligature-induced periodontal disease model. ( 29683497 )
2018
19
Local administration of curcumin-loaded nanoparticles effectively inhibits inflammation and bone resorption associated with experimental periodontal disease. ( 29703905 )
2018
20
Simvastatin alleviates bone resorption in apical periodontitis possibly by inhibition of mitophagy-related osteoblast apoptosis. ( 30537112 )
2018
21
Effects of theaflavins on tissue inflammation and bone resorption on experimental periodontitis in rats. ( 30159985 )
2018
22
Alveolar bone resorption and Th1/Th17-associated immune response triggered during Aggregatibacter actinomycetemcomitans-induced experimental periodontitis are serotype-dependent. ( 30030845 )
2018
23
Differential effects of natural Curcumin and chemically modified curcumin on inflammation and bone resorption in model of experimental periodontitis. ( 29669267 )
2018
24
Levels of oxidative stress biomarkers and bone resorption regulators in apical periodontitis lesions infected by Epstein-Barr virus. ( 29315650 )
2018
25
Anti-HMGB1 Neutralizing Antibody Attenuates Periodontal Inflammation and Bone Resorption in a Murine Periodontitis Model. ( 29531138 )
2018
26
OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9. ( 29533736 )
2018
27
Influence of chronic alcoholism and estrogen deficiency on the immunohistochemical expression of regulatory proteins of the bone resorption process in the periodontium of Wistar rats. ( 30031211 )
2018
28
Semaphorin 4D correlates with increased bone resorption, hypercalcemia, and disease stage in newly diagnosed patients with multiple myeloma. ( 29748532 )
2018
29
TSC1 regulates osteoclast podosome organization and bone resorption through mTORC1 and Rac1/Cdc42. ( 29358671 )
2018
30
Isoliquiritigenin blunts osteoarthritis by inhibition of bone resorption and angiogenesis in subchondral bone. ( 29379010 )
2018
31
The effect of the heights and thicknesses of the remaining root segments on buccal bone resorption in the socket-shield technique: An experimental study in dogs. ( 29417708 )
2018
32
Risedronate reduces postoperative bone resorption after cementless total hip arthroplasty: A systematic review and meta-analysis. ( 29448032 )
2018
33
Bone resorption: supporting immunometabolism. ( 29491030 )
2018
34
Osteoclast-secreted SLIT3 coordinates bone resorption and formation. ( 29504949 )
2018
35
Inhibiting checkpoint kinase 1 protects bone from bone resorption by mammary tumor in a mouse model. ( 29507695 )
2018
36
IL-6, IL-1β, and TNF-α only in combination influence the osteoporotic phenotype in Crohn's patients via bone formation and bone resorption. ( 29521042 )
2018
37
Does the Use of a "Walking Bleaching" Technique Increase Bone Resorption Markers? ( 29533717 )
2018
38
Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses. ( 29572961 )
2018
39
α-Melanocyte-stimulating hormone promotes bone resorption resulting from increased osteoblastic and osteoclastic activities in goldfish. ( 29574148 )
2018
40
Resolvin E1 Inhibits Osteoclastogenesis and Bone Resorption by Suppressing IL-17-induced RANKL Expression in Osteoblasts and RANKL-induced Osteoclast Differentiation. ( 29599617 )
2018
41
WAIF1 Is a Cell-Surface CTHRC1 Binding Protein Coupling Bone Resorption and Formation. ( 29624737 )
2018
42
Disruption of the mouse Slc39a14 gene encoding zinc transporter ZIP14 is associated with decreased bone mass, likely caused by enhanced bone resorption. ( 29632817 )
2018
43
Cepharanthine Prevents Estrogen Deficiency-Induced Bone Loss by Inhibiting Bone Resorption. ( 29636680 )
2018
44
Protein phosphatase 2A as a new target for downregulating osteoclastogenesis and alleviating titanium particle-induced bone resorption. ( 29656074 )
2018
45
The efficiency of risedronate in reducing bone resorption after total hip arthroplasty: a meta-analysis of randomized control trials at a minimum of 6 months' follow-up. ( 29665839 )
2018
46
Artemether attenuates LPS-induced inflammatory bone loss by inhibiting osteoclastogenesis and bone resorption via suppression of MAPK signaling pathway. ( 29703893 )
2018
47
Homocysteine levels are associated with bone resorption in pre-frail and frail Spanish women: The Toledo Study for Healthy Aging. ( 29704640 )
2018
48
In vivo visualisation of different modes of action of biological DMARDs inhibiting osteoclastic bone resorption. ( 29705743 )
2018
49
Advances in the discovery of cathepsin K inhibitors on bone resorption. ( 29723068 )
2018
50
Impact of crestal bone resorption on quality of life and professional maintenance with conventional dentures or locator-retained mandibular implant overdentures. ( 29724562 )
2018

Variations for Bone Resorption Disease

Expression for Bone Resorption Disease

Search GEO for disease gene expression data for Bone Resorption Disease.

Pathways for Bone Resorption Disease

GO Terms for Bone Resorption Disease

Cellular components related to Bone Resorption Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 BGLAP BMP2 CALCA CTSK IGF1 PTH
2 extracellular space GO:0005615 9.28 BGLAP BMP2 CALCA CTSK IGF1 PTH

Biological processes related to Bone Resorption Disease according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.96 BMP2 ESR1 IGF1 LRP5 NFATC1 PTH
2 regulation of signaling receptor activity GO:0010469 9.93 BMP2 CALCA IGF1 PTH TNFRSF11B TNFSF11
3 cell-cell signaling GO:0007267 9.92 BMP2 CALCA PTH TNFRSF11A
4 positive regulation of transcription, DNA-templated GO:0045893 9.91 BMP2 ESR1 IGF1 LRP5 NFATC1 RUNX2
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.83 ESR1 TNFRSF11A TNFSF11
6 cellular calcium ion homeostasis GO:0006874 9.83 CALCA PTH VDR
7 osteoblast differentiation GO:0001649 9.81 BGLAP BMP2 RUNX2 SP7
8 tumor necrosis factor-mediated signaling pathway GO:0033209 9.79 TNFRSF11A TNFRSF11B TNFSF11
9 response to estrogen GO:0043627 9.79 BGLAP ESR1 TNFRSF11B
10 cellular response to growth factor stimulus GO:0071363 9.77 BGLAP BMP2 TRPV1
11 response to heat GO:0009408 9.75 CALCA IGF1 TRPV1
12 monocyte chemotaxis GO:0002548 9.73 CALCA TNFRSF11A TNFSF11
13 bone mineralization GO:0030282 9.71 BGLAP BMP2 PTH
14 positive regulation of bone resorption GO:0045780 9.66 TNFRSF11A TNFSF11
15 positive regulation of glycogen biosynthetic process GO:0045725 9.65 IGF1 PTH
16 detection of temperature stimulus involved in sensory perception of pain GO:0050965 9.65 CALCA TRPV1
17 regulation of osteoclast differentiation GO:0045670 9.64 BGLAP TNFSF11
18 positive regulation of ossification GO:0045778 9.64 BMP2 PTH
19 negative regulation of bone resorption GO:0045779 9.63 CALCA TNFRSF11B
20 response to inorganic substance GO:0010035 9.63 BGLAP TNFRSF11B
21 positive regulation of osteoblast differentiation GO:0045669 9.62 BMP2 IGF1 LRP5 RUNX2
22 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus GO:1901522 9.61 BMP2 RUNX2
23 osteoblast development GO:0002076 9.61 BGLAP LRP5 RUNX2
24 regulation of odontogenesis of dentin-containing tooth GO:0042487 9.58 BMP2 RUNX2
25 mammary gland alveolus development GO:0060749 9.58 ESR1 TNFRSF11A TNFSF11
26 bone mineralization involved in bone maturation GO:0035630 9.57 BMP2 IGF1
27 TNFSF11-mediated signaling pathway GO:0071847 9.55 TNFRSF11A TNFSF11
28 mammary gland branching involved in pregnancy GO:0060745 9.52 ESR1 VDR
29 skeletal system development GO:0001501 9.5 BGLAP BMP2 IGF1 PTH RUNX2 TNFRSF11B
30 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.49 TNFRSF11A TNFSF11
31 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.48 TNFRSF11A TNFSF11
32 bone resorption GO:0045453 9.46 ACP5 CTSK PTH TNFSF11
33 ossification GO:0001503 9.17 ACP5 BGLAP BMP2 RUNX2 SOST TNFRSF11A
34 positive regulation of gene expression GO:0010628 10 BMP2 IGF1 RUNX2 TNFSF11 VDR

Molecular functions related to Bone Resorption Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 CALCA IGF1 PTH

Sources for Bone Resorption Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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34 ICD10 via Orphanet
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69 SNOMED-CT via HPO
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74 UMLS via Orphanet
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