Bone Resorption Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BNR002 MIFTS: 38	Bone Resorption Disease Categories: Bone diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Bone Resorption Disease

MalaCards integrated aliases for Bone Resorption Disease:

Name: Bone Resorption Disease ¹¹ ¹⁴

Bone Resorption ⁴³ ⁷⁵

Classifications:

MalaCards categories:
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0080011

MeSH ⁴³ D001862

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Summaries for Bone Resorption Disease

Disease Ontology: ¹¹ A bone remodeling disease that results in an abnormal decrease of bone density or mass.

MalaCards based summary: Bone Resorption Disease, also known as bone resorption, is related to paget disease of bone 5, juvenile-onset and osteopetrosis. An important gene associated with Bone Resorption Disease is MIR214 (MicroRNA 214), and among its related pathways/superpathways are MicroRNAs in cardiomyocyte hypertrophy and Mesenchymal Stem Cells and Lineage-specific Markers. The drugs Hyaluronic acid and Adalimumab have been mentioned in the context of this disorder. Affiliated tissues include bone, prostate and spinal cord, and related phenotypes are limbs/digits/tail and skeleton

Wikipedia: ⁷⁵ Bone resorption is resorption of bone tissue, that is, the process by which osteoclasts break down the... more...

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Related Diseases for Bone Resorption Disease

Diseases related to Bone Resorption Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 620)

#	Related Disease	Score	Top Affiliating Genes
1	paget disease of bone 5, juvenile-onset	32.4	TNFSF11 CALCA
2	osteopetrosis	32.4	TNFSF11 RUNX2 CTSK CALCA BGLAP ACP5
3	paget's disease of bone	32.4	TNFSF11 PTH CTSK CALCA BGLAP ACP5
4	osteitis fibrosa	32.4	SOST PTH CALCA BGLAP
5	glucocorticoid-induced osteoporosis	32.2	TNFSF11 SP7 SOST RUNX2 PTH MIR214
6	periodontitis	32.1	TNFSF11 RUNX2 MIR142 CTSK BGLAP ACP5
7	failure of tooth eruption, primary	32.1	SP7 PTH
8	osteoporosis	32.0	TNFSF11 SP7 SOST RUNX2 PTH MIR27A
9	bone disease	31.8	TNFSF11 SP7 SOST RUNX2 PTH MIR27A
10	rickets	31.7	PTH CALCA BGLAP
11	hyperparathyroidism	31.6	TNFSF11 SOST PTH CALCA BGLAP ACP5
12	mammary paget's disease	31.6	TNFSF11 SP7 SOST RUNX2 PTH CTSK
13	osteogenic sarcoma	31.5	TNFSF11 SP7 RUNX2 PTH MIR140 BGLAP
14	osteonecrosis	31.5	RUNX2 PTH BGLAP ACP5
15	osteoarthritis	31.5	TNFSF11 RUNX2 MIR140 CTSK BGLAP
16	myeloma, multiple	31.4	TNFSF11 MIR335 MIR27A MIR142 MIR140 BGLAP
17	periapical periodontitis	31.4	TNFSF11 SP7 RUNX2 CTSK BGLAP ACP5
18	secondary hyperparathyroidism	31.4	PTH CALCA BGLAP ACP5
19	bone giant cell tumor	31.3	TNFSF11 RUNX2 PTH CTSK CALCA ACP5
20	primary hyperparathyroidism	31.3	TNFSF11 SOST PTH CALCA BGLAP ACP5
21	hyperthyroidism	31.2	PTH CALCA BGLAP ACP5
22	chronic kidney disease	31.2	TNFSF11 SOST RUNX2 PTH CALCA BGLAP
23	osteomalacia	31.1	TNFSF11 SOST PTH CALCA BGLAP
24	pycnodysostosis	31.1	TNFSF11 SOST CTSK BGLAP ACP5
25	osteomyelitis	31.1	TNFSF11 CTSK CALCA ACP5
26	kidney disease	31.1	TNFSF11 SOST RUNX2 PTH CALCA BGLAP
27	hypercalcemia, infantile, 1	31.1	PTH CALCA
28	renal osteodystrophy	31.1	TNFSF11 PTH CALCA BGLAP ACP5
29	root resorption	31.1	TNFSF11 RUNX2 CALCA
30	spondyloarthropathy 1	31.0	TNFSF11 PTH BGLAP
31	exostosis	31.0	SOST RUNX2 BGLAP
32	ankylosis	30.9	TNFSF11 SP7 SOST RUNX2 BGLAP
33	bone cancer	30.9	MIR335 MIR29B1 MIR27A MIR23A MIR223 MIR214
34	sclerosteosis 1	30.9	SP7 SOST BGLAP
35	endosteal hyperostosis, autosomal dominant	30.9	TNFSF11 SP7 SOST PTH CTSK ACP5
36	hemiplegia	30.9	CALCA BGLAP ACP5
37	hypophosphatemia	30.9	SOST PTH BGLAP
38	sclerosteosis	30.8	TNFSF11 SP7 SOST RUNX2 PTH CTSK
39	hypoparathyroidism	30.8	PTH CALCA BGLAP
40	hypervitaminosis d	30.8	PTH CALCA
41	brittle bone disorder	30.7	TNFSF11 SP7 SOST RUNX2 PTH MIR214
42	osteochondrodysplasia	30.7	TNFSF11 SP7 SOST RUNX2 PTH MIR140
43	dental pulp necrosis	30.7	TNFSF11 RUNX2 BGLAP
44	bone inflammation disease	30.7	TNFSF11 MIR335 MIR29B1 MIR27A MIR23A MIR223
45	osteopetrosis, autosomal dominant 2	30.7	TNFSF11 CTSK BGLAP ACP5
46	chronic apical periodontitis	30.6	TNFSF11 RUNX2
47	oral squamous cell carcinoma	30.6	MIR29B1 MIR27A MIR23A MIR223 MIR214 MIR188
48	renal cell carcinoma, nonpapillary	30.6	MIR335 MIR29B1 MIR27A MIR23A MIR223 MIR214
49	scoliosis	30.6	TNFSF11 RUNX2 CTSK BGLAP ACP5
50	type 2 diabetes mellitus	30.6	PTH MIR335 MIR27A MIR23A MIR223 MIR214

Graphical network of the top 20 diseases related to Bone Resorption Disease:

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Symptoms & Phenotypes for Bone Resorption Disease

MGI Mouse Phenotypes related to Bone Resorption Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	limbs/digits/tail	MP:0005371	9.61	ACP5 CTSK MIR140 MIR188 PTH RUNX2
2	skeleton	MP:0005390	9.36	ACP5 BGLAP CALCA CTSK MIR140 MIR188

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Drugs & Therapeutics for Bone Resorption Disease

Drugs for Bone Resorption Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 88)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Hyaluronic acid

Approved, Vet_approved

Phase 4

9004-61-9

53477741

Adalimumab

Approved, Experimental

Phase 4

331731-18-1

Denosumab

Approved

Phase 4

615258-40-7

Alendronic acid

Approved

Phase 4

121268-17-5, 66376-36-1

2088

Ibandronate

Approved, Investigational

Phase 4

114084-78-5

60852

Teriparatide

Approved, Investigational

Phase 4

52232-67-4

16133850 155817470

Cholecalciferol

Approved, Nutraceutical, Vet_approved

Phase 4

67-97-0, 1406-16-2

5280795 10883523

Antirheumatic Agents

Phase 4

Anti-Inflammatory Agents

Phase 4

Trace Elements

Phase 4

Micronutrients

Phase 4

Diphosphonates

Phase 4

Vitamins

Phase 4

Calciferol

Phase 4

Calcium, Dietary

Phase 4

Hormones

Phase 4

Calcium

Nutraceutical

Phase 4

7440-70-2

271

Zoledronic acid

Approved

Phase 2, Phase 3

118072-93-8

68740

Anesthetics

Phase 3

Liver Extracts

Phase 2, Phase 3

Simvastatin

Approved

Phase 2

79902-63-9

54454

Saracatinib

Investigational

Phase 2

379231-04-6

10302451

Whey Protein

Phase 1, Phase 2

Antimetabolites

Phase 2

Hypolipidemic Agents

Phase 2

Anticholesteremic Agents

Phase 2

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 2

Lipid Regulating Agents

Phase 2

Aromatase Inhibitors

Phase 1, Phase 2

Flurbiprofen

Approved, Investigational

Phase 1

5104-49-4

3394

Celecoxib

Approved, Investigational

Phase 1

169590-42-5

2662

Ibuprofen

Approved

Phase 1

15687-27-1

3672

Analgesics

Phase 1

Cyclooxygenase Inhibitors

Phase 1

Cyclooxygenase 2 Inhibitors

Phase 1

Anti-Inflammatory Agents, Non-Steroidal

Phase 1

Analgesics, Non-Narcotic

Phase 1

Pharmaceutical Solutions

Phase 1

Povidone-iodine

Approved

25655-41-8

Sodium citrate

Approved, Investigational

68-04-2

23431961

Lidocaine

Approved, Vet_approved

137-58-6

3676

Dopamine

Approved

62-31-7, 51-61-6

681

Metamfetamine

Approved, Illicit, Withdrawn

537-46-2

10836

Amoxicillin

Approved, Vet_approved

26787-78-0

33613

Chlorhexidine

Approved, Vet_approved, Withdrawn

55-56-1

2713 9552079

Calcium carbonate

Approved, Investigational

471-34-1

Miconazole

Approved, Investigational, Vet_approved

22916-47-8

4189

Clotrimazole

Approved, Vet_approved

23593-75-1

2812

Salicylic acid

Approved, Investigational, Vet_approved

69-72-7

338

Glycolic acid

Approved, Investigational

79-14-1

757

Interventional clinical trials:

(show top 50) (show all 116)

#	Name	Status	NCT ID	Phase	Drugs
1	Hyaluronic Acid Effect on Xenogenic Bone Substitutes Healing During Ridge Preservations: A Radiological and Histomorphometric Study	Unknown status	NCT04377256	Phase 4
2	Bone Resorption, Osteoclastogenesis and Adalimumab	Unknown status	NCT02035800	Phase 4	Adalimumab
3	Evaluation of Anterior Alveolar Ridge Reconstruction With Allogenic Bone Plate and Autogenous Cortical Bone Chips: A Radiographic and Histological Clinical Study	Completed	NCT04324697	Phase 4
4	The Efficacy of Denosumab in Decreasing Periprosthetic Bone Loss in Patients With Total Knee Arthroplasty: A Randomised, Double Blind, Placebo Controlled Clinical Trial	Completed	NCT02760979	Phase 4	Denosumab;Placebo
5	Effects of 1% Sodium Alendronate in Non Surgical Periodontal Therapy on Clinical and Tomographical Parameters: a Randomized Placebo Controlled 6-month Clinical Trial	Completed	NCT02470611	Phase 4	Sodium alendronate
6	A Randomized, Double-blind, Placebo-controlled Study to Determine Time to Onset of Suppression of the Bone Resorption Marker sCTX With Once Monthly Ibandronate in the Treatment of Postmenopausal Osteoporosis	Completed	NCT00303485	Phase 4	Placebo;Vitamin D and calcium supplementation;ibandronate [Bonviva/Boniva]
7	Acute Effect of Teriparatide With Bisphosphonate or Denosumab on Bone Resorption	Completed	NCT01750086	Phase 4	Teriparatide 40-mcg subcutaneous injection;Denosumab Injection;Alendronate Oral Tablet
8	A Method for Measuring Volume Changes of the Alveolar Ridge During Dental Implantation Using 3D Scanning	Recruiting	NCT03089619	Phase 4	Human-Spongiosa
9	Ridge Preservation Comparing the Clinical and Histologic Healing of Two Different Putty Bone Grafts	Recruiting	NCT05484492	Phase 4
10	COMPARATIVE EVALUATION OF BIOACTIVE GLASS PUTTY AND PLATELET RICH FIBRIN IN THE TREATMENT OF HUMAN PERIODONTAL INTRABONY DEFECTS- A CLINICAL AND RADIOGRAPHICAL STUDY"	Completed	NCT02982681	Phase 3	Platelet rich fibrin;Bioactive Glass
11	Zoledronic Acid Versus Alendronate for Prevention of Bone Loss After Organ Transplantation	Completed	NCT00297830	Phase 2, Phase 3	Zoledronic acid;Alendronate
12	Study to Assess Efficacy and Safety of Zoledronic Acid and the Value of Markers of Bone Resorption in the Prediction of Bone Metastases and Cancer Treatment-induced Bone Loss (CTIBL) in Patients With Prostate Cancer on Hormone Therapy	Completed	NCT00172055	Phase 3	Zoledronic acid
13	Impact of a Protein Supplement on Bone Mass in Older Men and Women	Completed	NCT00421408	Phase 1, Phase 2
14	Restoration of Immediate Peri-implant Defect by Simvastatin: a Controlled Clinical and Cone Beam Computed Tomography Study	Completed	NCT04803500	Phase 2	Simvastatin;Placebo
15	Teh Histomorphometric Study of Nanocrystalline Hydroxyapatite (Nano Bone) Wif Alendronate in Teh Preservation of Teh Tooth Socket	Completed	NCT03980847	Phase 2	Alendronate 20 mg
16	The Effect Of Lasofoxifene On Local Mediators Of Bone Resorption In The Prevention Of Postmenopausal Osteoporosis	Completed	NCT00674453	Phase 2	Lasofoxifene
17	Proof of Concept (Bone Resorption/Bone Mineral Density) Study (0429-005)	Completed	NCT00533650	Phase 2	MK0429
18	A Phase II, Randomised, Open-Label, Pilot Study to Evaluate the Safety and Effects on Bone Resorption of AZD0530 in Patients With Prostate Cancer or Breast Cancer With Metastatic Bone Disease.	Completed	NCT00558272	Phase 2	AZD0530;Zoledronic Acid
19	Bone Quality and Quantity in the Maxillary Sinus Grafted With Xenograft or Synthetic Bone Substitute: A Radiographic and Histomorphometric Randomized Controlled Clinical Study	Recruiting	NCT04433117	Phase 2
20	Feasibility of Bisphosphonate Use on Sleeve Gastrectomy Associated Bone Loss: Healthy Body, Healthy Bones Trial	Active, not recruiting	NCT04279392	Phase 1, Phase 2	Zoledronic Acid 5 mg/Bag 100 ml Inj;Placebos
21	A Phase I/II Randomized, Double-blind, Controlled Study to Evaluate Efficacy and Safety of Vitamin D on Bone Mineral Density and Markers of Bone Resorption in Aromatase Inhibitor-induced Bone Loss in Women With Breast Cancer.	Terminated	NCT00904423	Phase 1, Phase 2	Vitamin D
22	Health of Young European Families and Fish Consumption	Unknown status	NCT00315770	Phase 1
23	Evaluation of Efficacy of Injectable Platelet-Rich Plasma (PRP) in Reducing Alveolar Bone Resorption Following Rapid Maxillary Expansion (RME): A Cone Beam Computed Tomography (CBCT) Assessment	Completed	NCT03028038	Phase 1	Platelet Rich Plasma;No Platelet Rich Plasma
24	A Double-Blind, Placebo-Controlled, Once-Weekly, Multiple-Dose Study to Investigate the Safety, Tolerability, Plasma Concentration Profile and Effects on Biochemical Markers of Bone Resorption of MK0822 in Healthy Postmenopausal Female Subjects	Completed	NCT00770159	Phase 1	odanacatib;Comparator: placebo to MK0822
25	The Effects of Non-steroidal Anti-inflammatory Drugs on Circulating Markers of Bone Metabolism Following Plyometric Exercise in Humans	Recruiting	NCT05512013	Phase 1	Ibuprofen 800 mg;Celecoxib 200mg;Flurbiprofen 100 mg;Placebo
26	Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting	Not yet recruiting	NCT04998058	Phase 1
27	Alveolar Ridge Preservation in Mandibular Molars Using Mixture of Autogenous Bone & Anorganic Bovine Bone (ABB) Versus Anorganic Bovine Bone Alone Versus Absorbent Gelatin Sponge	Unknown status	NCT03584984
28	Assessment of Vertical Bone Augmentation Using Autogenous Onlay Versus Inlay Grafting Techniques With Simultaneous Implant Placement in the Anterior Maxillary Area on Patient's Esthetic Satisfaction : A Randomized Clinical Trial	Unknown status	NCT03052387
29	Posterior Maxillary Ridge Augmentation With Sinus Lift Using Mineralized Plasmatic Matrix Versus Autogenous Bone Graft (A Randomized Clinical Trial Comparative Study)	Unknown status	NCT03014388
30	Clinical Evaluation and Primary Stability of Early Loaded Implants With Sandblasted and Acid-etched Surface Versus Implants With SA Surface Modified With pH Buffering Agent: a Multicenter Randomized Controlled Trial	Unknown status	NCT04073654
31	Ridge Augmentation in Atrophic Anterior Maxillary Ridges With Native Collagen Membrane and Anorganic Bovine Bone Derived Mineral With and Without Particulated Autogenous Bone Chips	Unknown status	NCT03731416
32	Evaluation of Computer-Guided Versus Conventional Simultaneous Implant Placement With Ridge Augmentation Using an Autogenous Bone Ring Graft With PRF on Patient's Esthetic Satisfaction	Unknown status	NCT03049137		Platelet-rich fibrin (PRF)
33	Effect of Citric Acid Demineralization on Autogenous Bone Blocks Consolidation in Humans: Qualitative, Quantitative and Immunohistochemical Analysis	Unknown status	NCT03357068
34	Clinical Assessment of Buccal Plate Expansion Technique Versus Guided Bone Regeneration Technique in Socket Preservation in The Esthetic Zone: A Randomized Controlled Clinical Trial	Unknown status	NCT03065803
35	Implant Insertion in Defective Anterior Maxillary Ridge Augmented Using Mineralized Plasmatic Matrix Versus Autogenous Bone Graft	Unknown status	NCT03007069
36	Study of Tooth Alveolar Extraction Socket Anatomy and Its Relation to Alveolar Post-extraction Changes	Unknown status	NCT01963884
37	Clinical, Radiographic and Histomorphometric Comparison of Autogenous Demineralized Dentin Matrix Versus Bovine-Derived Xenograft for Socket Preservation: A Randomised Controlled Clinical Trial	Unknown status	NCT04239378
38	Comparative Evaluation of Novel Ribose Cross Linked Volumising Collagen Matrix v/s Ribose Cross Linked Resorbable Collagen Membrane and Bone Graft for Lateral Ridge Augmentation Around Implants: A Randomised Controlled Clinical Trial	Unknown status	NCT04197128
39	Clinical Evaluation of the Effect of Low Speed Drilling Versus Conventional Drilling Technique on Crestal Bone Level in Maxilla. A Randomized Controlled Clinical Trial	Unknown status	NCT03220815
40	Standard Implants With Bone Regeneration vs Short Implants (Implantes Convencionales Con regeneración ósea vs. Implantes Cortos)	Unknown status	NCT03524885
41	Clinical Evaluation of the Effect of Low Speed Drilling Versus Conventional Drilling Technique on Crestal Bone Level in Maxilla. A Randomized Controlled Clinical Trial	Unknown status	NCT03212820
42	Evaluation of Vertical Bone Augmentation Using Anterior Maxillary Segmental Sandwich Osteotomy: Simultaneous Versus Delayed Implant Placement, A Randomized Controlled Trial	Unknown status	NCT04022538
43	Clinical Evaluation Of Dental Implants Stability Placed In Healed Bony Sites Following Over-drilling Compared To Conventional-Drilling Protocol: A Randomized Controlled Trial.	Unknown status	NCT03250949
44	Clinical Evaluation of the Effect of Low Speed Drilling Versus Conventional Drilling Technique on Crestal Bone Level in Maxilla. A Randomized Controlled Clinical Trial	Unknown status	NCT03220789
45	Alveolar Ridge Preservation In Mandibular Molars Using Mixture Of Anorganic Bovine Bone(ABB) And Autogenous Particulate VS Mixture Of Injectable Platelets Rich Fibrin, ABB And Autogenous Particulates (Sticky Bone).	Unknown status	NCT03584997
46	Influence of Soft Tissue Thickness and Insertion Depth of Platform Switched Implants on Crestal Bone Level Alteration	Unknown status	NCT02867982		prophylactic antibiotics
47	A Prospective, Randomized-controlled Study of the Effect of a Chlorhexidine Based Gel on the Internal Implant Surface Treatment on the Reduction of Bacterial Load and on the Regressive Bone Modelling.	Unknown status	NCT03431766
48	Bone Changes Assessment in Screw-Retained Maxillary Implant Supported Complete Denture With Electric Welded Metal Framework Versus Cast One (Randomized Control,Split Mouth Trial)	Unknown status	NCT04548258
49	Clinical Assessment of Buccal Bone Resorption in Immediate Implants in Thin and Thick Buccal Plates of Bone and Its Implication on Esthetics. A Controlled Clinical Trial	Unknown status	NCT04630665
50	Role of Light Emitting Diode on Implant Stability, Bone Resorption and Analgesia Post Dental Implant Placement	Unknown status	NCT01097499

Search NIH Clinical Center for Bone Resorption Disease

Cochrane evidence based reviews: bone resorption

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Genetic Tests for Bone Resorption Disease

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Anatomical Context for Bone Resorption Disease

Organs/tissues related to Bone Resorption Disease:

MalaCards : Bone, Prostate, Spinal Cord, Breast, Liver

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Publications for Bone Resorption Disease

Articles related to Bone Resorption Disease:

#	Title	Authors	PMID	Year
1	miR-30a-5p inhibits osteogenesis and promotes periodontitis by targeting Runx2. ⁶²	Liu X...Lu Q	34635105	2021
2	[Effect of inhibition of Porphyromonas endodontalis on osteoblast differentiation]. ⁶²	Wang R...Qiu LH	34693425	2021
3	Zoledronic acid : Treatment option for Gorham-Stout disease. ⁶²	Illeez OG...Aktas I	30280236	2018
4	CB(2) and TRPV(1) receptors oppositely modulate in vitro human osteoblast activity. ⁶²	Rossi F...Maione S	26117426	2015
5	Role of exopolysaccharide in Aggregatibacter actinomycetemcomitans-induced bone resorption in a rat model for periodontal disease. ⁶²	Shanmugam M...Ramasubbu N	25706999	2015
6	Bone biomarkers of ovariectomised rats after leptin therapy. ⁶²	Abdel-Sater KA...Mansour H	23731039	2013
7	New approaches to the treatment of osteoporosis. ⁶²	Lopez FJ	10959765	2000
8	The effect of rectally administered steroids on bone turnover: a comparative study. ⁶²	Robinson RJ...Mayberry JF	9570255	1998
9	Rectal steroids suppress bone formation in patients with colitis. ⁶²	Robinson RJ...Mayberry JF	9042994	1997
10	Flurbiprofen: a potent inhibitor of alveolar bone resorption in beagles. ⁶²	Williams RC...Wechter WJ	3969553	1985

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Genes for Bone Resorption Disease

Genes related to Bone Resorption Disease (0 elite genes):

(show top 50) (show all 70)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR214	MicroRNA 214	RNA Gene	10.76	DISEASES inferred ¹⁴ ¹⁴
2	MIR188	MicroRNA 188	RNA Gene	10.59	DISEASES inferred ¹⁴ ¹⁴
3	MIR140	MicroRNA 140	RNA Gene	10.53	DISEASES inferred ¹⁴ ¹⁴
4	BGLAP	Bone Gamma-Carboxyglutamate Protein	Protein Coding	10.15	DISEASES inferred ¹⁴
5	TNFSF11	TNF Superfamily Member 11	Protein Coding	10.15	DISEASES inferred ¹⁴
6	PTH	Parathyroid Hormone	Protein Coding	10.03	DISEASES inferred ¹⁴
7	MIR133A1	MicroRNA 133a-1	RNA Gene	9.85	DISEASES inferred ¹⁴ ¹⁴
8	MIR23A	MicroRNA 23a	RNA Gene	9.78	DISEASES inferred ¹⁴ ¹⁴
9	MIR550A1	MicroRNA 550a-1	RNA Gene	9.43	DISEASES inferred ¹⁴ ¹⁴
10	ACP5	Acid Phosphatase 5, Tartrate Resistant	Protein Coding	9.4	DISEASES inferred ¹⁴
11	SOST	Sclerostin	Protein Coding	9.39	DISEASES inferred ¹⁴
12	RUNX2	RUNX Family Transcription Factor 2	Protein Coding	9.36	DISEASES inferred ¹⁴
13	MIR335	MicroRNA 335	RNA Gene	9.28	DISEASES inferred ¹⁴ ¹⁴
14	CTSK	Cathepsin K	Protein Coding	9.11	DISEASES inferred ¹⁴
15	CALCA	Calcitonin Related Polypeptide Alpha	Protein Coding	9.1	DISEASES inferred ¹⁴
16	SP7	Sp7 Transcription Factor	Protein Coding	8.85	DISEASES inferred ¹⁴
17	MIR223	MicroRNA 223	RNA Gene	8.82	DISEASES inferred ¹⁴ ¹⁴
18	MIR29B1	MicroRNA 29b-1	RNA Gene	8.8	DISEASES inferred ¹⁴ ¹⁴
19	MIR27A	MicroRNA 27a	RNA Gene	8.78	DISEASES inferred ¹⁴ ¹⁴
20	MIR142	MicroRNA 142	RNA Gene	8.77	DISEASES inferred ¹⁴ ¹⁴
21	NFATC1	Nuclear Factor Of Activated T Cells 1	Protein Coding	8.75	DISEASES inferred ¹⁴
22	ESR1	Estrogen Receptor 1	Protein Coding	8.74	DISEASES inferred ¹⁴
23	BMP2	Bone Morphogenetic Protein 2	Protein Coding	8.7	DISEASES inferred ¹⁴
24	MIR503	MicroRNA 503	RNA Gene	8.7	DISEASES inferred ¹⁴ ¹⁴
25	MIR483	MicroRNA 483	RNA Gene	8.58	DISEASES inferred ¹⁴ ¹⁴
26	MIR199A1	MicroRNA 199a-1	RNA Gene	8.55	DISEASES inferred ¹⁴ ¹⁴
27	LRP5	LDL Receptor Related Protein 5	Protein Coding	8.43	DISEASES inferred ¹⁴
28	MIR143	MicroRNA 143	RNA Gene	8.43	DISEASES inferred ¹⁴ ¹⁴
29	MIR93	MicroRNA 93	RNA Gene	8.42	DISEASES inferred ¹⁴ ¹⁴
30	MIR122	MicroRNA 122	RNA Gene	8.36	DISEASES inferred ¹⁴ ¹⁴
31	IL6	Interleukin 6	Protein Coding	8.36	DISEASES inferred ¹⁴
32	MIR17	MicroRNA 17	RNA Gene	8.35	DISEASES inferred ¹⁴ ¹⁴
33	IGF1	Insulin Like Growth Factor 1	Protein Coding	8.32	DISEASES inferred ¹⁴
34	SPP1	Secreted Phosphoprotein 1	Protein Coding	8.23	DISEASES inferred ¹⁴
35	MIR675	MicroRNA 675	RNA Gene	8.19	DISEASES inferred ¹⁴ ¹⁴
36	MIR126	MicroRNA 126	RNA Gene	8.18	DISEASES inferred ¹⁴ ¹⁴
37	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	8.18	DISEASES inferred ¹⁴ ¹⁴
38	TNF	Tumor Necrosis Factor	Protein Coding	8.15	DISEASES inferred ¹⁴
39	H2AC18	H2A Clustered Histone 18	Protein Coding	8.15	DISEASES inferred ¹⁴ ¹⁴
40	MIR532	MicroRNA 532	RNA Gene	8.08	DISEASES inferred ¹⁴ ¹⁴
41	MIR149	MicroRNA 149	RNA Gene	8.08	DISEASES inferred ¹⁴ ¹⁴
42	CTNNB1	Catenin Beta 1	Protein Coding	8.06	DISEASES inferred ¹⁴
43	MIR196A1	MicroRNA 196a-1	RNA Gene	8.06	DISEASES inferred ¹⁴ ¹⁴
44	DKK1	Dickkopf WNT Signaling Pathway Inhibitor 1	Protein Coding	8.03	DISEASES inferred ¹⁴
45	MIR150	MicroRNA 150	RNA Gene	8.02	DISEASES inferred ¹⁴ ¹⁴
46	IBSP	Integrin Binding Sialoprotein	Protein Coding	7.98	DISEASES inferred ¹⁴
47	MIR221	MicroRNA 221	RNA Gene	7.97	DISEASES inferred ¹⁴ ¹⁴
48	INS	Insulin	Protein Coding	7.95	DISEASES inferred ¹⁴
49	MIR10A	MicroRNA 10a	RNA Gene	7.94	DISEASES inferred ¹⁴ ¹⁴
50	MIR382	MicroRNA 382	RNA Gene	7.92	DISEASES inferred ¹⁴ ¹⁴

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Variations for Bone Resorption Disease

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Expression for Bone Resorption Disease

Search GEO for disease gene expression data for Bone Resorption Disease.

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Pathways for Bone Resorption Disease

Pathways related to Bone Resorption Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	MicroRNAs in cardiomyocyte hypertrophy ⁷⁴ Show member pathways Cardiac hypertrophic response ⁷⁴	11.9	MIR23A MIR214 MIR140 MIR133A1
2	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	11.68	SP7 RUNX2 PTH BGLAP
3	Cell differentiation - expanded index ⁷⁴ Show member pathways Cell differentiation - index ⁷⁴	11.57	RUNX2 MIR223 MIR214 MIR133A1
4	miRNAs involved in DNA damage response ⁷⁴	11.45	MIR223 MIR23A MIR27A MIR29B1
5	RUNX2 regulates bone development ⁶⁶ Show member pathways RUNX2 regulates chondrocyte maturation ⁶⁶ RUNX2 regulates osteoblast differentiation ⁶⁶	11.44	SP7 RUNX2 BGLAP
6	Interactions between immune cells and microRNAs in tumor microenvironment ⁷⁴	11.31	MIR27A MIR23A MIR214
7	Development_Hedgehog and PTH signaling pathways in bone and cartilage development ²²	11.15	TNFSF11 RUNX2 PTH BGLAP
8	Clock-controlled autophagy in bone metabolism ⁷⁴	11.07	TNFSF11 SP7 SOST RUNX2 PTH CTSK
9	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.01	TNFSF11 RUNX2 PTH CALCA BGLAP
10	OSX and miRNAs in tooth development ⁷⁴	10.98	SP7 SOST RUNX2 MIR29B1

Sources

GO Terms for Bone Resorption Disease

Cellular components related to Bone Resorption Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.98	BGLAP CALCA CTSK MIR133A1 MIR140 MIR142
2	RISC complex	GO:0016442	9.62	MIR550A1 MIR335 MIR29B1 MIR27A MIR23A MIR223
3	extracellular vesicle	GO:1903561	9.46	MIR29B1 MIR27A MIR23A MIR214

Biological processes related to Bone Resorption Disease according to GeneCards Suite gene sharing:

(show all 14)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of gene expression	GO:0010629	9.99	PTH MIR29B1 MIR27A MIR214 MIR140
2	ossification	GO:0001503	9.97	TNFSF11 SOST RUNX2 CALCA BGLAP
3	miRNA-mediated gene silencing	GO:0035195	9.96	MIR133A1 MIR140 MIR142 MIR188 MIR214 MIR223
4	positive regulation of gene expression	GO:0010628	9.93	TNFSF11 RUNX2 PTH MIR29B1 MIR27A MIR23A
5	cellular response to zinc ion starvation	GO:0034224	9.88	SP7 CTSK BGLAP
6	bone resorption	GO:0045453	9.86	ACP5 CTSK PTH TNFSF11
7	negative regulation of BMP signaling pathway	GO:0030514	9.84	SOST MIR214 MIR140
8	negative regulation of cell migration	GO:0030336	9.83	MIR335 MIR29B1 MIR214 MIR133A1
9	negative regulation of vascular associated smooth muscle cell proliferation	GO:1904706	9.67	MIR223 MIR214 MIR140 MIR133A1
10	negative regulation of vascular associated smooth muscle cell migration	GO:1904753	9.65	MIR223 MIR214 MIR140
11	negative regulation of SMAD protein signal transduction	GO:0060392	9.61	MIR140 MIR23A MIR27A
12	negative regulation of BMP secretion	GO:2001285	9.49	MIR214 MIR140
13	positive regulation of Fas signaling pathway	GO:1902046	9.46	MIR27A MIR23A
14	miRNA-mediated gene silencing by mRNA destabilization	GO:0035279	9.02	MIR27A MIR23A MIR223 MIR214 MIR140

Molecular functions related to Bone Resorption Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3'-UTR binding	GO:0003730	9.61	MIR335 MIR29B1 MIR27A MIR23A MIR223 MIR214
2	mRNA base-pairing translational repressor activity	GO:1903231	9.32	MIR335 MIR29B1 MIR27A MIR23A MIR223 MIR214