Bone Sarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BNS007 MIFTS: 42	Bone Sarcoma Categories: Bone diseases, Cancer diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Bone Sarcoma

MalaCards integrated aliases for Bone Sarcoma:

Name: Bone Sarcoma ⁵⁸

Characteristics:

Orphanet epidemiological data:

⁵⁸

bone sarcoma
Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare bone diseases

External Ids:

UMLS via Orphanet ⁷² C0029463 C1704327

Orphanet ⁵⁸ ORPHA223727

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Summaries for Bone Sarcoma

MalaCards based summary : Bone Sarcoma is related to ewing sarcoma and neutropenia. An important gene associated with Bone Sarcoma is MTAP (Methylthioadenosine Phosphorylase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Miconazole and Dasatinib have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related phenotypes are cardiovascular system and hematopoietic system

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Related Diseases for Bone Sarcoma

Diseases related to Bone Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 408)

#	Related Disease	Score	Top Affiliating Genes
1	ewing sarcoma	30.7	DES CSF3 CCNB3 BCOR
2	neutropenia	30.1	IL6 IL1RN CSF3 CSF1
3	sarcoma	30.0	TNFRSF1A SRC MTAP IL6 CXCL8
4	paracoccidioidomycosis	29.6	IL6 IL10 CTLA4
5	malignant mesenchymoma	29.6	MB DES
6	mesenchymoma	29.6	MB DES
7	acute cystitis	29.5	IL6 IL10 CXCL8
8	diarrhea	29.4	IL6 IL10 CXCL8 CSF3
9	spondylitis	29.3	IL6 IL1RN IL10
10	rhabdomyosarcoma 2	29.3	MB DES CCNB3 BCOR
11	osteomyelitis	29.2	IL6 IL1RN IL10 CXCL8 CSF3
12	spondyloarthropathy 1	29.2	TNFRSF1A IL1RN IL1R1
13	stomatitis	29.0	IL6 IL1RN IL10 CXCL8 CSF3
14	exanthem	28.9	IL6 IL1RN IL10 CXCL8 CTLA4 CSF3
15	synovitis	28.8	TNFRSF1A IL6 IL1RN CXCL8
16	toxic shock syndrome	28.6	IL6 IL1RN IL1R1 IL10 CXCL8
17	bone inflammation disease	28.2	TNFRSF1A IL6 IL1RN IL10 CXCL8 CTLA4
18	severe combined immunodeficiency	28.2	IL6 IL1RN IL1R1 IL18R1 IL10 CSF3
19	thrombocytopenia	28.0	SRC IL6 IL1RN IL10 CXCL8 CTLA4
20	myeloma, multiple	27.3	TNFRSF1A SRC IL6 IL10 CXCL8 CTLA4
21	systemic lupus erythematosus	27.2	TNFRSF1A IL6 IL1RN IL1R1 IL10 CXCL8
22	osteogenic sarcoma	11.7
23	diaphyseal medullary stenosis with malignant fibrous histiocytoma	11.3
24	li-fraumeni syndrome	11.1
25	li-fraumeni syndrome 2	11.1
26	spindle cell sarcoma	10.8
27	soft tissue sarcoma	10.6
28	chondrosarcoma	10.6
29	leukoregulin	10.5	CXCL8 CSF1
30	small cell sarcoma	10.5	CCNB3 BCOR
31	engraftment syndrome	10.4	CXCL8 CSF3
32	spotted fever rickettsiosis	10.4	IL10 CTLA4
33	kidney sarcoma	10.4	CCNB3 BCOR
34	dermatitis, atopic, 8	10.4	IL10 CXCL8
35	doxorubicin induced cardiomyopathy	10.4	DES CSF3
36	neurosyphilis	10.4	IL10 CXCL8
37	ossifying fibromyxoid tumor	10.3	DES CCNB3 BCOR
38	cyclic neutropenia	10.3	CXCL8 CSF3 CSF1
39	leiomyosarcoma	10.3
40	pouchitis	10.3	IL1RN CXCL8
41	undifferentiated pleomorphic sarcoma	10.3
42	histiocytoma	10.3
43	idiopathic anterior uveitis	10.3	IL6 CXCL8
44	streptococcal toxic-shock syndrome	10.3	IL6 CXCL8
45	fibrous histiocytoma	10.3
46	paraneoplastic syndromes	10.3	IL6 CSF3
47	scabies	10.2	IL10 CXCL8 CSF3
48	malignant fibroxanthoma	10.2
49	progressive muscular dystrophy	10.2	MTAP MB
50	small cell osteogenic sarcoma	10.2	CCNB3 BCOR

Graphical network of the top 20 diseases related to Bone Sarcoma:

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Symptoms & Phenotypes for Bone Sarcoma

MGI Mouse Phenotypes related to Bone Sarcoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	10.23	BCOR CSF1 CTLA4 DES IL10 IL18R1
2	hematopoietic system	MP:0005397	10.18	BCOR CSF1 CSF3 CTLA4 IL10 IL18R1
3	cellular	MP:0005384	10.17	BCOR CCNB3 CSF1 DES IL10 IL1R1
4	immune system	MP:0005387	10.15	BCOR CSF1 CSF3 CTLA4 IL10 IL18R1
5	integument	MP:0010771	9.97	CSF1 CSF3 CTLA4 IL10 IL1R1 IL1RN
6	mortality/aging	MP:0010768	9.93	BCOR CSF1 CTLA4 DES IL10 IL1R1
7	liver/biliary system	MP:0005370	9.8	CSF1 CTLA4 IL10 IL1R1 IL6 MTAP
8	muscle	MP:0005369	9.5	CSF1 DES IL10 IL1R1 IL6 MB
9	respiratory system	MP:0005388	9.28	CSF1 CTLA4 IL10 IL1R1 IL6 MB

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Drugs & Therapeutics for Bone Sarcoma

Drugs for Bone Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

Dasatinib

Approved, Investigational

Phase 2

302962-49-8

3062316

Dacarbazine

Approved, Investigational

Phase 2

4342-03-4

5351166

Vincristine

Approved, Investigational

Phase 2

2068-78-2, 57-22-7

5978

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

Fludarabine

Approved

Phase 2

21679-14-1, 75607-67-9

30751

Vidarabine

Approved, Investigational

Phase 2

24356-66-9

32326 21704

Aldesleukin

Approved

Phase 2

110942-02-4, 85898-30-2

Pembrolizumab

Approved

Phase 2

1374853-91-4

nivolumab

Approved

Phase 1, Phase 2

946414-94-4

Sunitinib

Approved, Investigational

Phase 1, Phase 2

341031-54-7, 557795-19-4

5329102

Cisplatin

Approved

Phase 1, Phase 2

15663-27-1

84093 441203 2767

Ifosfamide

Approved

Phase 2

3778-73-2

3690

Mechlorethamine

Approved, Investigational

Phase 2

51-75-2

4033

Sorafenib

Approved, Investigational

Phase 2

284461-73-0

216239 406563

Methotrexate

Approved

Phase 2

1959-05-2, 59-05-2

126941

leucovorin

Approved

Phase 2

58-05-9

6006 143

Doxorubicin

Approved, Investigational

Phase 2

23214-92-8

31703

Irinotecan

Approved, Investigational

Phase 2

97682-44-5, 100286-90-6

60838

Lenograstim

Approved, Investigational

Phase 2

135968-09-1

Levoleucovorin

Approved, Investigational

Phase 2

68538-85-2

Vitamin C

Approved, Nutraceutical

Phase 2

50-81-7

5785 54670067

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 2

59-30-3

6037

Exatecan

Investigational

Phase 2

171335-80-1

Camptothecin

Experimental

Phase 2

7689-03-4

Emodepside

Investigational, Vet_approved

Phase 2

155030-63-0

Interferon-alpha

Phase 2

Interferon alpha-2

Phase 2

interferons

Phase 2

Anti-Infective Agents

Phase 2

Antihypertensive Agents

Phase 2

Veratrum Alkaloids

Phase 2

Imatinib Mesylate

Phase 2

220127-57-1

123596

Antibodies, Monoclonal

Phase 2

Antifungal Agents

Phase 2

Cyclosporins

Phase 2

Calcineurin Inhibitors

Phase 2

Interleukin-2

Phase 2

Anti-Retroviral Agents

Phase 2

Analgesics, Non-Narcotic

Phase 2

Anti-HIV Agents

Phase 2

Analgesics

Phase 2

Vidarabine Phosphate

Phase 2

Angiogenesis Inhibitors

Phase 1, Phase 2

Antineoplastic Agents, Immunological

Phase 2

Immunoglobulins

Phase 2

Antibodies

Phase 2

Pharmaceutical Solutions

Phase 1, Phase 2

Antiviral Agents

Phase 2

Anti-Bacterial Agents

Phase 2

Interventional clinical trials:

(show all 43)

#	Name	Status	NCT ID	Phase	Drugs
1	Phase II Study of Low-Dose Interferon Alfa 2B (Schering Plough) Plus Thalidomide (Celgene) for Patients With Resected High-Risk Soft Tissue Sarcoma	Unknown status	NCT00026416	Phase 2	thalidomide
2	PhaseⅡ Study of Weekly Docetaxel and Fixed-Dose Rate Gemcitabine in Patient With Previously Treated Advanced Soft Tissue and Bone Sarcoma Prospective, Open Label, Multi-Institutional	Unknown status	NCT00807261	Phase 2	Gemcitabine and Docetaxel
3	A Phase 2, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of IPI-926 in Patients With Metastatic or Locally Advanced (Unresectable) Chondrosarcoma	Completed	NCT01310816	Phase 2	IPI-926;Placebo Arm
4	Phase II Trial of Gleevec (Formerly Known as STI571) in Patients With Soft Tissue and Bone Sarcomas: A Multi-Disciplinary Trial of the North American Sarcoma Study Group of the Connective Tissue Oncology Society	Completed	NCT00031915	Phase 2	imatinib mesylate
5	A Phase 2 Study of Temsirolimus (CCI-779, NSC 683864) and IGF-1 Receptor Antibody Cixutumumab (IMC-A12, NSC 742460) in Patients With Metastatic Sarcomas	Completed	NCT01016015	Phase 2	Temsirolimus
6	Exatecan As Second-Line Treatment In Advanced Adult Soft Tissue Sarcoma: A Phase II - Study Of The EORTC Soft Tissue And Bone Sarcoma Group	Completed	NCT00041236	Phase 2	exatecan mesylate
7	A Phase II Trial of Dasatinib in Advanced Sarcomas	Completed	NCT00464620	Phase 2	Dasatinib
8	Phase II Trial of Linsitinib (Anti-IGF-1R/IR) in Patients With Relapsed and/or Refractory Ewing Sarcoma	Completed	NCT02546544	Phase 2	Linsitinib
9	Exploratory Study of Non-Myeloablative Allogeneic Stem Cell Transplantation and Donor Lymphocyte Infusions for Metastatic Neoplasms Refractory to Standard Therapy	Completed	NCT00001880	Phase 2	methotrexate;cyclosporin
10	Determination of Tumor Response Rate by RECIST and FDG-PET Criteria to Dacarbazine in Metastatic Soft Tissue and Bone Sarcoma	Completed	NCT00802880	Phase 2	Dacarbazine
11	A Phase II Study to Evaluate the Pharmacokinetics, Safety, and Obtain a Preliminary Efficacy Assessment of Palifermin in Patients With Sarcoma Receiving Multicycle Chemotherapy With Doxorubicin and Ifosfamide	Completed	NCT00267046	Phase 2	Palifermin;Placebo;Adriamycin (Doxorubicin);Ifosfamide;Vincristine;Cisplatin
12	Abemaciclib for Treatment of Advanced Bone and Soft Tissue Sarcoma Identified as Having CDK Pathway Alteration	Recruiting	NCT04040205	Phase 2	Abemaciclib
13	Clinical Study to Assess Efficacy and Safety of LN-145 (Autologous Centrally Manufactured Tumor Infiltrating Lymphocytes) Across Multiple Tumor Types	Recruiting	NCT03449108	Phase 2	Cyclophosphamide;Fludarabine;Fludarabine Phosphate
14	SARC028: A Phase II Study of the Anti-PD1 Antibody Pembrolizumab (MK-3475) in Patients With Advanced Sarcomas	Active, not recruiting	NCT02301039	Phase 2	Pembrolizumab
15	Phase I-II Trial of Sunitinib Plus Nivolumab After Standard Treatment in Advanced Soft Tissue and Bone Sarcomas	Active, not recruiting	NCT03277924	Phase 1, Phase 2	Sunitinib 37.5 MG [Sutent];Nivolumab 10 MG/ML [Opdivo]
16	Phase I/ II Study of Pulmonary Suffusion to Control Minimal Residual Disease in Resectable Sarcoma Pulmonary Metastases	Not yet recruiting	NCT03965234	Phase 1, Phase 2	Cisplatin
17	A Phase II Trial of Gemcitabine Plus High-Dose Ascorbate in Locally Advanced Unresectable or Metastatic Soft Tissue and Bone Sarcomas in Adults	Suspended	NCT03468075	Phase 2	Ascorbate;Gemcitabine
18	A Phase II Study of Sorafenib and Ifosfamide as a Treatment for Patients With Sarcoma	Terminated	NCT00880542	Phase 2	sorafenib;Ifosfamide
19	Phase II Trial of Neoadjuvant Dose-Dense Doxorubicin, Ifosfamide, and Irinotecan (CPT-11) for Advanced Soft Tissue and Recurrent Bone Sarcomas	Terminated	NCT00544778	Phase 2	dexrazoxane hydrochloride;doxorubicin hydrochloride;ifosfamide;irinotecan hydrochloride
20	A Randomised, Cross-over Phase II Study to Investigate the Efficacy and Safety of Glucarpidase for Routine Use After High Dose Methotrexate in Patients With Bone Sarcoma	Terminated	NCT02022358	Phase 2	Glucarpidase;Methotrexate;Folinic Acid
21	An Open-Label Phase IB Trial To Evaluate the Effects of Food and Formulation on Pharmacokinetics of the Oral Selective Inhibitor of Nuclear Export/SINE Compound KPT-330 in Patients With Soft-Tissue or Bone Sarcoma	Completed	NCT01896505	Phase 1	KCP-330
22	To Evaluate the Efficacy of NY-ESO-1-specific T Cell Receptor (TCR) Affinity Enhancing Specific T Cell in Bone and Soft Tissue Sarcoma	Recruiting	NCT03462316	Phase 1
23	In Vivo Lung Perfusion (IVLP) as an Adjuvant Treatment for Patients Undergoing Surgical Resection of Pulmonary Metastases of Bone and Soft Tissues Sarcomas	Recruiting	NCT02811523	Phase 1	Doxorubicin
24	A Phase I/II Open-label Study of Eltrombopag for the Prevention of Chemotherapy Induced Thrombocytopenia (CIT) in Subjects With Advanced Soft Tissue and Bone Sarcomas Receiving Gemcitabine and Docetaxel Chemotherapy	Terminated	NCT01491594	Phase 1	Eltrombopag
25	A Multi-center Phase I Trial of Temsirolimus in Combination With Valproic Acid in Children and Adolescents With Multiply Relapsed Pediatric Solid Tumors	Terminated	NCT01204450	Phase 1	Temsirolimus;Valproic Acid
26	Osteosarcoma and Ewing Sarcoma Treatment Response Assessment With Functional MRI Imaging in Children and Young Adults	Unknown status	NCT01780779
27	Neutrophil Extracellular Traps (NETs) Formation Following Chemotherapy for Pediatric Hematological and Solid Tumors, and Its Relation to Other Neutrophil Functions and the Role of NETs in Antitumor Activity	Unknown status	NCT01533779
28	Quantifying and Measuring the Economic Impact of Nursing Activities During the Hospital Stay of High Complexity Oncologic Care Patients	Unknown status	NCT02845583
29	Functional and Clinical Long-Term Outcome of Ewing Sarcoma Treatment	Completed	NCT00824083
30	A European Treatment Protocol for Bone-sarcoma in Patients Older Than 40 Years	Completed	NCT02986503		Doxorubicin+cisplatin+ifosfamide;Doxorubicin+cisplatin+ifosfamide+methotrexate
31	Long Term Clinical and Functional Outcome in Patients Operated on Van Ness-Borggreve Rotationplasty for Lower Limnb Bone Tumor	Completed	NCT03385694
32	Dynamic Contrast Enhanced MRI(DCE-MRI)of Bone Tumors	Completed	NCT00598741
33	Clinical Evaluation for Sarcoma Originated From Bone	Recruiting	NCT03358992
34	Pre-Surgical Supervised Exercise for Bone Cancer Patients	Recruiting	NCT02893397
35	Transcultural Validation of MSTS and TESS Questionnaire	Recruiting	NCT03765970
36	ICONIC: Improving Outcomes Through Collaboration in OsteosarComa	Recruiting	NCT04132895
37	Incorporating the Patient Voice in Sarcoma Research: How Can we Assess Health-related Quality of Life in This Heterogeneous Group of Patients?	Recruiting	NCT04071704
38	Assessment of Healing and Function After Surgical Reconstruction for Osseous Sarcomas	Recruiting	NCT03442465
39	Observational Study, for Quality Assessment, of Sarcoma as a Model to Improve Diagnosis and Clinical Care of Rare Tumors Through a European and Latin American Multidisciplinary NETWORK	Recruiting	NCT04181970
40	Etiosarc: Study of the Environmental Aetiology (Environment, Occupations and Lifestyle) of Sarcomas (Soft Tissue, Visceral and Bone) From a Multicenter French Population-based Case-control Study Among Adults.	Recruiting	NCT03670927
41	DVT Prophylaxis in Orthopaedic Oncology Patients - A Safety Study	Active, not recruiting	NCT00525057		Dalteparin
42	Prospective Evaluation of Abscopal Radiation Effects on Regional and Distant Bone	Enrolling by invitation	NCT03134742
43	A Randomized, Placebo-controlled, Double-blinded, Multicentre Study Evaluating the Efficacy and Safety of Regorafenib as Maintenance Therapy After First-line Treatment in Patients With Bone Sarcomas	Not yet recruiting	NCT04055220		Treatment by Regorafenib;Treatment by Placebo

Search NIH Clinical Center for Bone Sarcoma

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Genetic Tests for Bone Sarcoma

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Anatomical Context for Bone Sarcoma

MalaCards organs/tissues related to Bone Sarcoma:

⁴⁰

Bone, Kidney, Lung, T Cells, Eye, Breast, Brain

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Publications for Bone Sarcoma

Articles related to Bone Sarcoma:

(show top 50) (show all 802)

#	Title	Authors	PMID	Year
1	The miR-143/145 Cluster, a Novel Diagnostic Biomarker in Chondrosarcoma, Acts as a Tumor Suppressor and Directly Inhibits Fascin-1. ⁶¹	Urdinez J...Gvozdenovic A	32027760	2020
2	Sacral chordoma: do the width of surgical margin and the use of photon/proton radiotherapy affect local disease control? ⁶¹	Fujiwara T...Jeys L	31863159	2020
3	Omic approaches to pediatric bone sarcomas. ⁶¹	Tirtei E...Fagioli F	31736201	2020
4	Experiences of return to work after treatment for extremital soft tissue or bone sarcoma: Between distraction and leaving the disease behind. ⁶¹	Zambrano SC...Bernhard J	32017298	2020
5	Use of a simple form to facilitate communication on long-term consequences of treatment in sarcoma survivors. ⁶¹	Hompland I...Bruland OS	31969978	2020
6	The long-term results of extendable endoprostheses of the humerus in children after the resection of a bone sarcoma. ⁶¹	Tsuda Y...Abudu A	31888359	2020
7	Long-term outcomes of limb salvage treatment with custom-made extendible endoprosthesis for bone sarcoma around the knee in children. ⁶¹	Zou C...Shen J	31948458	2020
8	Application of Low Doses of Ionizing Radiation in Medical Therapies. ⁶¹	Cuttler JM	31933547	2020
9	[Treatment concepts for complications after resection and defect reconstruction of pelvic tumours]. ⁶¹	Hardes J...Nottrott M	31996946	2020
10	Oncological and endoprosthetic outcomes of bone sarcoma patients: a nationwide cohort study. ⁶¹	Mavcic B...Martincic D	31324968	2020
11	Upregulation of miRNA-154-5p prevents the tumorigenesis of osteosarcoma. ⁶¹	Tian Q...Han Q	32000044	2020
12	The sensitivity, specificity, and diagnostic accuracy of whole-bone MRI for identifying skip metastases in appendicular osteosarcoma and Ewing sarcoma. ⁶¹	Barnett JR...Saifuddin A	31900513	2020
13	Bone sarcomas in the immunotherapy era. ⁶¹	Heymann MF...Heymann D	31975481	2020
14	The incidence of skip metastases on whole bone MRI in high-grade bone sarcomas. ⁶¹	Saifuddin A...Pressney I	31919587	2020
15	Primary bone sarcoma with BCOR internal tandem duplication. ⁶¹	Malik F...Bahrami A	31900635	2020
16	The management of desmoid tumours: A joint global consensus-based guideline approach for adult and paediatric patients. ⁶¹	Desmoid Tumor Working Group	32004793	2020
17	Denosumab in patients with giant-cell tumour of bone: a multicentre, open-label, phase 2 study. ⁶¹	Chawla S...Palmerini E	31704134	2019
18	Selective Agonists of Nuclear Retinoic Acid Receptor Gamma Inhibit Growth of HCS-2/8 Chondrosarcoma Cells. ⁶¹	Shield WP...Enomoto-Iwamoto M	31808569	2019
19	Bone and Soft-Tissue Sarcoma Risk in Long-Term Survivors of Hereditary Retinoblastoma Treated With Radiation. ⁶¹	Kleinerman RA...Morton LM	31622129	2019
20	Incidence, mortality, and survival trends of soft tissue and bone sarcoma in Switzerland between 1996 and 2015. ⁶¹	Kollar A...NICER Working Group	31520938	2019
21	Pediatric extremity bone sarcoma reconstruction with the vascularized fibula flap: Observational study assessing long-term functional outcomes, complications, and survival. ⁶¹	Ruiz-Moya A...Gomez-Cia T	31563475	2019
22	Diagnostic accuracy of primary bone and soft tissue sarcomas by 18-FDG PET: Systematic review and meta-analysis. ⁶¹	Younis M...Thalib L	31887730	2019
23	What is the Likelihood That Tumor Endoprostheses Will Experience a Second Complication After First Revision in Patients With Primary Malignant Bone Tumors And What Are Potential Risk Factors? ⁶¹	Theil C...Andreou D	31764339	2019
24	The association between socioeconomic position and tumour size, grade, stage, and mortality in Danish sarcoma patients - A national, observational study from 2000 to 2013. ⁶¹	Raedkjaer M...Vedsted P	31702424	2019
25	Antiproliferative effect of the histone demethylase inhibitor GSK-J4 in chondrosarcomas. ⁶¹	Lhuissier E...Bauge C	31241814	2019
26	The adrenergic receptor antagonists propranolol and carvedilol decrease bone sarcoma cell viability and sustained carvedilol reduces clonogenic survival and increases radiosensitivity in canine osteosarcoma cells. ⁶¹	Duckett MM...Lawrence J	31778284	2019
27	Construction of Anti-hPD-L1 HCAb Nb6 and in Situ124I Labeling for Noninvasive Detection of PD-L1 Expression in Human Bone Sarcoma. ⁶¹	Huang HF...Yang Z	31535847	2019
28	Radiotherapy for the Palliation of Advanced Sarcomas-The Effectiveness of Radiotherapy in Providing Symptomatic Improvement for Advanced Sarcomas in a Single Centre Cohort. ⁶¹	Tween H...Sherriff J	31635409	2019
29	Factors associated with functional outcome in patients having limb salvage surgery for primary malignant bone sarcoma using TESS. ⁶¹	Bamdad K...Briggs T	31528081	2019
30	Ion channels in sarcoma: pathophysiology and treatment options. ⁶¹	Aung T...Haerteis S	31377822	2019
31	[The importance of radiology in bone sarcoma diagnostics : Initial and advanced diagnostics]. ⁶¹	Vieth V	31392388	2019
32	Identifying bone sarcoma survivors facing psychosocial challenges. A study of trajectories following treatment. ⁶¹	Fauske L...Bjorndal A	31184795	2019
33	Stanmore noninvasive extendible endoprosthesis in the treatment of bone sarcoma in the preadolescent. ⁶¹	Sambri A...Manfrini M	31093984	2019
34	Bone Sarcoma With EWSR1-NFATC2 Fusion: Sarcoma With Varied Morphology and Amplification of Fusion Gene Distinct From Ewing Sarcoma. ⁶¹	Yau DTW...Chan ACL	30714449	2019
35	Bone sarcoma patient-derived xenografts are faithful and stable preclinical models for molecular and therapeutic investigations. ⁶¹	Nanni P...Scotlandi K	31434953	2019
36	The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1. ⁶¹	Miao W...Song D	31253399	2019
37	What is the Likelihood That Tumor Endoprostheses Will Experience a Second Complication After First Revision in Patients With Primary Malignant Bone Tumors And What Are Potential Risk Factors? ⁶¹	Theil C...Andreou D	31490349	2019
38	Can Navigation Improve the Ability to Achieve Tumor-free Margins in Pelvic and Sacral Primary Bone Sarcoma Resections? A Historically Controlled Study. ⁶¹	Bosma SE...Dijkstra PDS	31107331	2019
39	CORR® Tumor Board: Can Navigation Improve the Ability to Achieve Tumor-free Margins in Pelvic and Sacral Primary Bone Sarcoma Resections? A Historically Controlled Study. ⁶¹	Anderson ME...Vargas SO	31169622	2019
40	CORR Insights®: Can Navigation Improve the Ability to Achieve Tumor-free Margins in Pelvic and Sacral Primary Bone Sarcoma Resections? A Historically Controlled Study. ⁶¹	Lozano-Calderon SA	31135541	2019
41	SFCE METRO-01 four-drug metronomic regimen phase II trial for pediatric extracranial tumor. ⁶¹	Heng-Maillard MA...Andre N	30920117	2019
42	Management of Sarcoma in Adolescents and Young Adults: An Australian Population-Based Study. ⁶¹	White VM...Anazodo A	30822262	2019
43	Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice. ⁶¹	Stamatopoulos A...Tsiridis E	30956944	2019
44	Assessment of resection margins in bone sarcoma treated by neoadjuvant chemotherapy: Literature review and guidelines of the bone group (GROUPOS) of the French sarcoma group and bone tumor study group (GSF-GETO/RESOS). ⁶¹	Gomez-Brouchet A...GROUPOS (GSF-GETO RESOS)	30962172	2019
45	Bone sarcoma incidence in the Netherlands. ⁶¹	Goedhart LM...Jutte PC	30903831	2019
46	Resection margins obtained with patient-specific instruments for resecting primary pelvic bone sarcomas: A case-control study. ⁶¹	Evrard R...Docquier PL	30982774	2019
47	Deep integrative analysis of microRNA-mRNA regulatory networks for biomarker and target discovery in chondrosarcoma. ⁶¹	Sui J...Kong Y	30520120	2019
48	Current review of surgical management options for extremity bone sarcomas. ⁶¹	Cirstoiu C...Nica M	31191985	2019
49	Effective nutritional status screening in orthopaedic oncology patients and post-operative complications. ⁶¹	Eu CW...Yasin NF	31084248	2019
50	Decision-making in Orthopaedic Oncology: Does Cognitive Bias Affect a Virtual Patient's Choice Between Limb Salvage and Amputation? ⁶¹	Gurich RW...Thompson MJ	31173578	2019

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Genes for Bone Sarcoma

Genes related to Bone Sarcoma (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MTAP	Methylthioadenosine Phosphorylase	Protein Coding	7.51	GeneCards inferred via : Disorders (show sections)
2	CSF1	Colony Stimulating Factor 1	Protein Coding	6.66	GeneCards inferred via : Publications (show sections)
3	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	6.66	GeneCards inferred via : Publications (show sections)
4	BCOR	BCL6 Corepressor	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
5	CCNB3	Cyclin B3	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
6	CSF3	Colony Stimulating Factor 3	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
7	CXCL8	C-X-C Motif Chemokine Ligand 8	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
8	DES	Desmin	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
9	GSTA1	Glutathione S-Transferase Alpha 1	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
10	IL10	Interleukin 10	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
11	IL18R1	Interleukin 18 Receptor 1	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
12	IL1R1	Interleukin 1 Receptor Type 1	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
13	IL1RN	Interleukin 1 Receptor Antagonist	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
14	IL6	Interleukin 6	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
15	MB	Myoglobin	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
16	SRC	SRC Proto-Oncogene, Non-Receptor Tyrosine Kinase	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)
17	TNFRSF1A	TNF Receptor Superfamily Member 1A	Protein Coding	6.31	GeneCards inferred via : Publications (show sections)

Sources

Variations for Bone Sarcoma

Sources

Expression for Bone Sarcoma

Search GEO for disease gene expression data for Bone Sarcoma.

Sources

Pathways for Bone Sarcoma

Pathways related to Bone Sarcoma according to GeneCards Suite gene sharing:

(show all 36)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁵ Show member pathways Immune System ⁶⁵ Neutrophil degranulation ⁶⁵	13.94	TNFRSF1A SRC IL6 IL1RN IL1R1 IL18R1
2	ERK Signaling ⁶³ Show member pathways ILK Signaling ⁶³ MAPK Signaling ⁶³ Molecular Mechanisms of Cancer ⁶³ Rho Family GTPases ⁶³	13.75	TNFRSF1A SRC IL6 IL1R1 IL18R1 IL10
3	PEDF Induced Signaling ⁶³ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶³ Cytokine-cytokine receptor interaction ³⁶ Endothelin-1 Signaling Pathway ⁶³ Glucocorticoid Receptor Signaling ⁶³ IL-6 Pathway ⁶³ MIF Mediated Glucocorticoid Regulation ⁶³ MIF Regulation of Innate Immune Cells ⁶³ NFAT Signaling and Lymphocyte Interactions ⁶³ PGC1Alpha Pathway ⁶³ RAR-Gamma-RXR-Alpha Degradation ⁶³ STAT3 Pathway ⁶³	13.5	TNFRSF1A SRC IL6 IL1RN IL1R1 IL18R1
4	Akt Signaling ⁶³ Show member pathways p38 Signaling ⁶³ Tec Kinases Signaling ⁶³	13.23	TNFRSF1A SRC IL6 IL1R1 IL18R1 IL10
5	PAK Pathway ⁶³ Show member pathways Antioxidant Action of Vitamin-C ⁶³ Epithelial Adherens Junctions ⁶³	13.09	TNFRSF1A SRC IL6 IL1R1 IL18R1 IL10
6	Cytokine Signaling in Immune system ⁶⁵ Show member pathways Signaling by Interleukins ⁶⁵	12.96	TNFRSF1A SRC IL6 IL1RN IL1R1 IL18R1
7	Human cytomegalovirus infection ³⁶ Show member pathways Human immunodeficiency virus 1 infection ³⁶ Kaposi sarcoma-associated herpesvirus infection ³⁶	12.86	TNFRSF1A SRC IL6 IL1R1 CXCL8 CCNB3
8	Shigellosis ³⁶	12.32	TNFRSF1A SRC IL1R1 CXCL8
9	Pathogenic Escherichia coli infection ³⁶	12.23	TNFRSF1A IL6 IL1R1 CXCL8
10	Tuberculosis ³⁶	12.17	TNFRSF1A SRC IL6 IL10
11	Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions ⁶⁴ Show member pathways Chemokine receptors bind chemokines ⁶⁵ Viral protein interaction with cytokine and cytokine receptor ³⁶	12.13	TNFRSF1A IL6 IL18R1 IL10 CXCL8 CSF1
12	Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways ¹	12.1	IL6 IL1RN IL10 CXCL8
13	Fluid shear stress and atherosclerosis ³⁶	12.02	TNFRSF1A SRC IL1R1 GSTA1
14	Th1 Differentiation Pathway ⁶⁴ Show member pathways IL27-mediated signaling events ¹ Th17 Differentiation Pathway ⁶⁴	11.98	IL6 IL1R1 IL18R1 IL10
15	Yersinia infection ³⁶	11.94	SRC IL6 IL10 CXCL8
16	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.9	IL6 IL10 CSF3 CSF1
17	Senescence and Autophagy in Cancer ¹	11.87	SRC IL6 CXCL8
18	TNF signaling pathway ³⁶	11.87	TNFRSF1A IL6 IL18R1 CSF1
19	NF-kappa B signaling pathway ³⁶	11.85	TNFRSF1A IL1R1 CXCL8
20	Amoebiasis ³⁶	11.82	IL6 IL1R1 IL10 CXCL8
21	Cytokine production by Th17 cells in CF (Mouse model) ²² Show member pathways Cytokine production by Th17 cells in CF ²²	11.81	IL6 CXCL8 CSF3
22	Hematopoietic cell lineage ³⁶	11.79	IL6 IL1R1 CSF3 CSF1
23	Rheumatoid arthritis ³⁶	11.75	IL6 CXCL8 CTLA4 CSF1
24	Pertussis ³⁶	11.72	IL6 IL10 CXCL8
25	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.7	IL6 IL10 CSF1
26	IL-1 Family Signaling Pathways ⁶⁴ Show member pathways Immune response IL-1 signaling pathway ²² Mucin expression in CF via TLRs, EGFR signaling pathways ²²	11.68	SRC IL6 IL1RN IL1R1 IL18R1 CXCL8
27	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁴	11.67	IL6 IL1RN IL10
28	LPA receptor mediated events ¹	11.63	SRC IL6 CXCL8
29	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.61	TNFRSF1A IL6 CXCL8
30	Lung fibrosis ¹	11.61	IL6 CXCL8 CSF3
31	Hematopoietic Stem Cell Differentiation ¹	11.46	IL6 CSF3 CSF1
32	Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway ¹	11.45	SRC IL6 CXCL8
33	Malaria ³⁶	11.4	IL6 IL10 CXCL8 CSF3
34	Cytokines and Inflammatory Response ¹	11.02	IL6 IL10 CSF3 CSF1
35	G-protein signaling_Rap2B regulation pathway ²²	10.93	IL6 IL10 DES CXCL8 CSF3 CSF1
36	Interleukin-10 signaling ⁶⁵	10.92	TNFRSF1A IL6 IL1RN IL1R1 IL10 CXCL8

Sources

GO Terms for Bone Sarcoma

Biological processes related to Bone Sarcoma according to GeneCards Suite gene sharing:

(show all 12)

#	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:0007165	10.02	TNFRSF1A SRC IL6 IL1RN IL1R1 IL18R1
2	immune response	GO:0006955	9.76	IL6 IL1RN IL1R1 IL18R1 IL10 CXCL8
3	cellular response to lipopolysaccharide	GO:0071222	9.73	SRC IL6 IL1RN IL10 CXCL8 CSF3
4	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.67	SRC IL6 CSF3
5	response to glucocorticoid	GO:0051384	9.61	IL6 IL1RN IL10
6	inflammatory response	GO:0006954	9.56	TNFRSF1A IL6 IL1RN IL1R1 IL18R1 IL10
7	branching involved in mammary gland duct morphogenesis	GO:0060444	9.51	SRC CSF1
8	response to molecule of bacterial origin	GO:0002237	9.48	IL10 CXCL8
9	negative regulation of heterotypic cell-cell adhesion	GO:0034115	9.46	IL1RN IL10
10	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.4	IL6 IL1RN
11	positive regulation of T-helper 1 cell cytokine production	GO:2000556	9.37	IL1R1 IL18R1
12	cytokine-mediated signaling pathway	GO:0019221	9.23	TNFRSF1A IL6 IL1RN IL1R1 IL10 CXCL8

Molecular functions related to Bone Sarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:0008083	9.26	IL6 IL10 CSF3 CSF1
2	interleukin-1 receptor activity	GO:0004908	9.16	IL1R1 IL18R1
3	cytokine activity	GO:0005125	9.1	IL6 IL1RN IL10 CXCL8 CSF3 CSF1

Sources

Sources for Bone Sarcoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia