MCID: BNS007
MIFTS: 42

Bone Sarcoma

Categories: Bone diseases, Cancer diseases, Rare diseases

Aliases & Classifications for Bone Sarcoma

MalaCards integrated aliases for Bone Sarcoma:

Name: Bone Sarcoma 58

Characteristics:

Orphanet epidemiological data:

58
bone sarcoma
Prevalence: 1-9/1000000 (Europe),1-9/100000 (Europe);

Classifications:

Orphanet: 58  
Rare bone diseases


External Ids:

UMLS via Orphanet 72 C0029463 C1704327
Orphanet 58 ORPHA223727

Summaries for Bone Sarcoma

MalaCards based summary : Bone Sarcoma is related to ewing sarcoma and neutropenia. An important gene associated with Bone Sarcoma is MTAP (Methylthioadenosine Phosphorylase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Miconazole and Dasatinib have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and lung, and related phenotypes are cardiovascular system and hematopoietic system

Related Diseases for Bone Sarcoma

Diseases related to Bone Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 408)
# Related Disease Score Top Affiliating Genes
1 ewing sarcoma 30.7 DES CSF3 CCNB3 BCOR
2 neutropenia 30.1 IL6 IL1RN CSF3 CSF1
3 sarcoma 30.0 TNFRSF1A SRC MTAP IL6 CXCL8
4 paracoccidioidomycosis 29.6 IL6 IL10 CTLA4
5 malignant mesenchymoma 29.6 MB DES
6 mesenchymoma 29.6 MB DES
7 acute cystitis 29.5 IL6 IL10 CXCL8
8 diarrhea 29.4 IL6 IL10 CXCL8 CSF3
9 spondylitis 29.3 IL6 IL1RN IL10
10 rhabdomyosarcoma 2 29.3 MB DES CCNB3 BCOR
11 osteomyelitis 29.2 IL6 IL1RN IL10 CXCL8 CSF3
12 spondyloarthropathy 1 29.2 TNFRSF1A IL1RN IL1R1
13 stomatitis 29.0 IL6 IL1RN IL10 CXCL8 CSF3
14 exanthem 28.9 IL6 IL1RN IL10 CXCL8 CTLA4 CSF3
15 synovitis 28.8 TNFRSF1A IL6 IL1RN CXCL8
16 toxic shock syndrome 28.6 IL6 IL1RN IL1R1 IL10 CXCL8
17 bone inflammation disease 28.2 TNFRSF1A IL6 IL1RN IL10 CXCL8 CTLA4
18 severe combined immunodeficiency 28.2 IL6 IL1RN IL1R1 IL18R1 IL10 CSF3
19 thrombocytopenia 28.0 SRC IL6 IL1RN IL10 CXCL8 CTLA4
20 myeloma, multiple 27.3 TNFRSF1A SRC IL6 IL10 CXCL8 CTLA4
21 systemic lupus erythematosus 27.2 TNFRSF1A IL6 IL1RN IL1R1 IL10 CXCL8
22 osteogenic sarcoma 11.7
23 diaphyseal medullary stenosis with malignant fibrous histiocytoma 11.3
24 li-fraumeni syndrome 11.1
25 li-fraumeni syndrome 2 11.1
26 spindle cell sarcoma 10.8
27 soft tissue sarcoma 10.6
28 chondrosarcoma 10.6
29 leukoregulin 10.5 CXCL8 CSF1
30 small cell sarcoma 10.5 CCNB3 BCOR
31 engraftment syndrome 10.4 CXCL8 CSF3
32 spotted fever rickettsiosis 10.4 IL10 CTLA4
33 kidney sarcoma 10.4 CCNB3 BCOR
34 dermatitis, atopic, 8 10.4 IL10 CXCL8
35 doxorubicin induced cardiomyopathy 10.4 DES CSF3
36 neurosyphilis 10.4 IL10 CXCL8
37 ossifying fibromyxoid tumor 10.3 DES CCNB3 BCOR
38 cyclic neutropenia 10.3 CXCL8 CSF3 CSF1
39 leiomyosarcoma 10.3
40 pouchitis 10.3 IL1RN CXCL8
41 undifferentiated pleomorphic sarcoma 10.3
42 histiocytoma 10.3
43 idiopathic anterior uveitis 10.3 IL6 CXCL8
44 streptococcal toxic-shock syndrome 10.3 IL6 CXCL8
45 fibrous histiocytoma 10.3
46 paraneoplastic syndromes 10.3 IL6 CSF3
47 scabies 10.2 IL10 CXCL8 CSF3
48 malignant fibroxanthoma 10.2
49 progressive muscular dystrophy 10.2 MTAP MB
50 small cell osteogenic sarcoma 10.2 CCNB3 BCOR

Graphical network of the top 20 diseases related to Bone Sarcoma:



Diseases related to Bone Sarcoma

Symptoms & Phenotypes for Bone Sarcoma

MGI Mouse Phenotypes related to Bone Sarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.23 BCOR CSF1 CTLA4 DES IL10 IL18R1
2 hematopoietic system MP:0005397 10.18 BCOR CSF1 CSF3 CTLA4 IL10 IL18R1
3 cellular MP:0005384 10.17 BCOR CCNB3 CSF1 DES IL10 IL1R1
4 immune system MP:0005387 10.15 BCOR CSF1 CSF3 CTLA4 IL10 IL18R1
5 integument MP:0010771 9.97 CSF1 CSF3 CTLA4 IL10 IL1R1 IL1RN
6 mortality/aging MP:0010768 9.93 BCOR CSF1 CTLA4 DES IL10 IL1R1
7 liver/biliary system MP:0005370 9.8 CSF1 CTLA4 IL10 IL1R1 IL6 MTAP
8 muscle MP:0005369 9.5 CSF1 DES IL10 IL1R1 IL6 MB
9 respiratory system MP:0005388 9.28 CSF1 CTLA4 IL10 IL1R1 IL6 MB

Drugs & Therapeutics for Bone Sarcoma

Drugs for Bone Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
2
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
3
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
4
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
5
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907