MCID: BNS004
MIFTS: 32

Bone Squamous Cell Carcinoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Squamous Cell Carcinoma

MalaCards integrated aliases for Bone Squamous Cell Carcinoma:

Name: Bone Squamous Cell Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050896

Summaries for Bone Squamous Cell Carcinoma

Disease Ontology : 12 A bone carcinoma that derives from squamous epithelial cells.

MalaCards based summary : Bone Squamous Cell Carcinoma is related to squamous cell carcinoma and skin carcinoma in situ. An important gene associated with Bone Squamous Cell Carcinoma is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Glioma and Proteoglycans in cancer. Affiliated tissues include bone, lung and skin, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Bone Squamous Cell Carcinoma

Diseases related to Bone Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.3
2 skin carcinoma in situ 10.1 CDKN2A STAT3
3 gastric adenosquamous carcinoma 10.1 CDKN2A STAT3
4 cervix carcinoma 10.1 CDKN2A STAT3
5 drug-induced lupus erythematosus 10.1 ENG KDR
6 laryngeal disease 10.0 CDKN2A ENG
7 fibrosarcoma of bone 10.0 CDKN2A KDR
8 plasmablastic lymphoma 10.0 CDKN2A NOTCH1
9 vascular cancer 10.0 ENG KDR
10 larynx cancer 10.0 CDKN2A ENG SERPINB5
11 gastrointestinal system cancer 9.9 CDKN2A KDR STAT3
12 endocrine gland cancer 9.9 CDKN2A KDR STAT3
13 arteriovenous malformations of the brain 9.9 ENG KDR
14 glioblastoma multiforme 9.9 CDKN2A KDR STAT3
15 squamous cell carcinoma, head and neck 9.9 CDKN2A CTTN STAT3
16 adenoid cystic carcinoma 9.9 CTTN NOTCH1 SERPINB5
17 epidermoid cysts 9.8
18 osteomyelitis 9.8
19 mucormycosis 9.8
20 cervical adenosquamous carcinoma 9.8 CDKN2A KDR NOTCH1
21 gastric adenocarcinoma 9.8 CDKN2A KDR SERPINB5 STAT3
22 hematologic cancer 9.8 ENG KDR NOTCH1
23 pancreas adenocarcinoma 9.8 CDKN2A NOTCH1 SERPINB5 STAT3
24 ewing sarcoma 9.8 CDKN2A ENG KDR STAT3
25 supratentorial cancer 9.7 CDKN2A KDR NOTCH1 STAT3
26 cerebrum cancer 9.7 CDKN2A KDR NOTCH1 STAT3
27 large intestine cancer 9.7 CDKN2A KDR NOTCH1 STAT3
28 pancreatic cancer 9.7 CDKN2A KDR SERPINB5 STAT3
29 brain cancer 9.6 KDR NOTCH1 STAT3
30 bone cancer 9.4 CDKN2A ENG NOTCH1 RECK RLN2

Graphical network of the top 20 diseases related to Bone Squamous Cell Carcinoma:



Diseases related to Bone Squamous Cell Carcinoma

Symptoms & Phenotypes for Bone Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.36 CTTN
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.36 STAT3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.36 STAT3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.36 SERPINB5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.36 CTTN SERPINB5 STAT3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.36 STAT3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.36 STAT3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.36 SERPINB5
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-94 9.36 SERPINB5

MGI Mouse Phenotypes related to Bone Squamous Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 10.03 CDKN2A CTTN ENG KDR NOTCH1 RECK
2 cardiovascular system MP:0005385 10.02 CDKN2A CTTN ENG KDR NOTCH1 RECK
3 growth/size/body region MP:0005378 10.01 CDKN2A CTTN ENG KDR NOTCH1 RECK
4 cellular MP:0005384 10 CDKN2A CTTN KDR NOTCH1 RECK SERPINB5
5 hematopoietic system MP:0005397 9.91 CDKN2A CTTN ENG KDR NOTCH1 SERPINB5
6 integument MP:0010771 9.8 CDKN2A ENG KDR NOTCH1 RECK STAT3
7 mortality/aging MP:0010768 9.76 CDKN2A CTTN ENG KDR NOTCH1 RECK
8 liver/biliary system MP:0005370 9.65 CDKN2A KDR NOTCH1 RECK STAT3
9 muscle MP:0005369 9.35 CDKN2A ENG KDR NOTCH1 STAT3
10 respiratory system MP:0005388 9.1 CDKN2A CTTN ENG KDR NOTCH1 STAT3

Drugs & Therapeutics for Bone Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Bone Squamous Cell Carcinoma

Genetic Tests for Bone Squamous Cell Carcinoma

Anatomical Context for Bone Squamous Cell Carcinoma

MalaCards organs/tissues related to Bone Squamous Cell Carcinoma:

41
Bone, Lung, Skin, Brain, Tongue, Pancreas, Cervix

Publications for Bone Squamous Cell Carcinoma

Articles related to Bone Squamous Cell Carcinoma:

# Title Authors Year
1
Survival impact of local extension sites in surgically treated patients with temporal bone squamous cell carcinoma. ( 28044211 )
2017
2
Dramatic response of CTNNB1 and VEGFR-2 mutant temporal bone squamous cell carcinoma to bevacizumab in combination with pemetrexed. ( 28915721 )
2017
3
Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma. ( 27488595 )
2016
4
Temporal bone squamous cell carcinoma - Penang experience. ( 26988214 )
2015
5
Temporal bone squamous cell carcinoma: analyzing prognosis with univariate and multivariate models. ( 24108656 )
2014
6
Evaluation of the prognostic role of pSTAT3 expression in temporal bone squamous cell carcinoma. ( 24005169 )
2013
7
Survival Outcomes of Patients with Temporal Bone Squamous Cell Carcinoma with Different Invasion Patterns. ( 24347537 )
2013
8
A case of skull base mucormycosis with osteomyelitis secondary to temporal bone squamous cell carcinoma. ( 17240707 )
2006

Variations for Bone Squamous Cell Carcinoma

Expression for Bone Squamous Cell Carcinoma

Search GEO for disease gene expression data for Bone Squamous Cell Carcinoma.

Pathways for Bone Squamous Cell Carcinoma

GO Terms for Bone Squamous Cell Carcinoma

Cellular components related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 ENG KDR NOTCH1

Biological processes related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.77 ENG KDR NOTCH1
2 angiogenesis GO:0001525 9.77 ENG KDR NOTCH1
3 positive regulation of cell migration GO:0030335 9.76 KDR NOTCH1 STAT3
4 extracellular matrix organization GO:0030198 9.73 KDR RECK SERPINB5
5 positive regulation of Notch signaling pathway GO:0045747 9.61 NOTCH1 STAT3
6 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.58 KDR NOTCH1
7 positive regulation of BMP signaling pathway GO:0030513 9.57 ENG NOTCH1
8 endocardial cushion morphogenesis GO:0003203 9.55 ENG NOTCH1
9 positive regulation of gene expression GO:0010628 9.55 CDKN2A ENG NOTCH1 RLN2 STAT3
10 ventricular trabecula myocardium morphogenesis GO:0003222 9.54 ENG NOTCH1
11 regulation of epithelial cell proliferation GO:0050678 9.52 NOTCH1 SERPINB5
12 negative regulation of stem cell differentiation GO:2000737 9.51 NOTCH1 STAT3
13 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.49 ENG NOTCH1
14 cardiac ventricle morphogenesis GO:0003208 9.48 ENG NOTCH1
15 somatic stem cell division GO:0048103 9.46 CDKN2A NOTCH1
16 astrocyte differentiation GO:0048708 9.43 NOTCH1 STAT3
17 cardiac atrium morphogenesis GO:0003209 9.4 ENG NOTCH1
18 response to corticosteroid GO:0031960 9.37 ENG NOTCH1
19 venous blood vessel morphogenesis GO:0048845 9.32 ENG NOTCH1
20 cell migration involved in endocardial cushion formation GO:0003273 9.26 ENG NOTCH1
21 positive regulation of angiogenesis GO:0045766 9.26 ENG KDR RLN2 STAT3
22 sprouting angiogenesis GO:0002040 8.8 ENG NOTCH1 RECK

Molecular functions related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 8.8 ENG KDR NOTCH1

Sources for Bone Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....