MCID: BNS004
MIFTS: 34

Bone Squamous Cell Carcinoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Squamous Cell Carcinoma

MalaCards integrated aliases for Bone Squamous Cell Carcinoma:

Name: Bone Squamous Cell Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050896

Summaries for Bone Squamous Cell Carcinoma

Disease Ontology : 12 A bone carcinoma that derives from squamous epithelial cells.

MalaCards based summary : Bone Squamous Cell Carcinoma is related to squamous cell carcinoma and skin carcinoma in situ. An important gene associated with Bone Squamous Cell Carcinoma is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include bone, tongue and cervix, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Bone Squamous Cell Carcinoma

Diseases related to Bone Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 29.9 CDKN2A CTTN NOTCH1 TP53
2 skin carcinoma in situ 10.3 CDKN2A STAT3
3 drug-induced lupus erythematosus 10.2 ENG KDR
4 non-proliferative fibrocystic change of the breast 10.1 ENG TP53
5 plasmablastic lymphoma 10.1 CDKN2A NOTCH1
6 bladder squamous cell carcinoma 10.1 CDKN2A TP53
7 keratinizing squamous cell carcinoma 10.1 CDKN2A TP53
8 spitz nevus 10.1 CDKN2A TP53
9 bladder carcinoma in situ 10.1 CDKN2A TP53
10 vulva squamous cell carcinoma 10.1 CDKN2A TP53
11 scrotal carcinoma 10.1 CDKN2A TP53
12 thyroid lymphoma 10.1 CDKN2A TP53
13 vulvar disease 10.1 CDKN2A TP53
14 nasal cavity adenocarcinoma 10.1 CDKN2A TP53
15 bartholin's gland disease 10.1 CDKN2A TP53
16 anal squamous cell carcinoma 10.1 CDKN2A TP53
17 megaesophagus 10.1 CDKN2A TP53
18 glycogen-rich clear cell breast carcinoma 10.1 CDKN2A TP53
19 anogenital venereal wart 10.1 CDKN2A TP53
20 cervix uteri carcinoma in situ 10.1 CDKN2A TP53
21 uterus carcinoma in situ 10.1 CDKN2A TP53
22 oral leukoplakia 10.1 CDKN2A TP53
23 meningeal melanomatosis 10.1 CDKN2A TP53
24 suppressor of tumorigenicity 3 10.1 CDKN2A TP53
25 dedifferentiated liposarcoma 10.1 CDKN2A TP53
26 endocervical adenocarcinoma 10.1 CDKN2A TP53
27 splenic diffuse red pulp small b-cell lymphoma 10.1 NOTCH1 TP53
28 penile disease 10.1 CDKN2A TP53
29 invasive bladder transitional cell carcinoma 10.1 NOTCH1 TP53
30 cervix small cell carcinoma 10.0 CDKN2A TP53
31 necrotizing sialometaplasia 10.0 CDKN2A TP53
32 verrucous carcinoma 10.0 CDKN2A TP53
33 basaloid squamous cell carcinoma 10.0 CDKN2A TP53
34 tongue disease 10.0 CDKN2A TP53
35 optic nerve neoplasm 10.0 CDKN2A TP53
36 spinal cord astrocytoma 10.0 NOTCH1 TP53
37 juvenile pilocytic astrocytoma 10.0 CDKN2A TP53
38 fibrosarcoma of bone 10.0 CDKN2A KDR
39 cheilitis 10.0 SERPINB5 TP53
40 tonsil cancer 10.0 CDKN2A TP53
41 gastric adenosquamous carcinoma 10.0 CDKN2A STAT3 TP53
42 cervix carcinoma 10.0 CDKN2A STAT3 TP53
43 pre-malignant neoplasm 10.0 CDKN2A TP53
44 richter's syndrome 10.0 NOTCH1 TP53
45 central nervous system cancer 10.0 CDKN2A STAT3 TP53
46 respiratory system cancer 10.0 CDKN2A STAT3 TP53
47 vulva cancer 10.0 CDKN2A TP53
48 gastrointestinal system disease 10.0 CDKN2A STAT3 TP53
49 mantle cell lymphoma 10.0 CDKN2A STAT3 TP53
50 squamous cell papilloma 9.9 CDKN2A TP53

Graphical network of the top 20 diseases related to Bone Squamous Cell Carcinoma:



Diseases related to Bone Squamous Cell Carcinoma

Symptoms & Phenotypes for Bone Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.36 CTTN
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.36 STAT3
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.36 STAT3
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.36 SERPINB5
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.36 CTTN SERPINB5 STAT3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.36 STAT3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.36 STAT3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.36 SERPINB5
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-94 9.36 SERPINB5

MGI Mouse Phenotypes related to Bone Squamous Cell Carcinoma:

47 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 CDKN2A CTTN ENG KDR NOTCH1 RECK
2 embryo MP:0005380 10.11 CDKN2A CTTN ENG KDR NOTCH1 RECK
3 cellular MP:0005384 10.1 CDKN2A CTTN KDR NOTCH1 RECK SERPINB5
4 growth/size/body region MP:0005378 10.09 CDKN2A CTTN ENG KDR NOTCH1 RECK
5 hematopoietic system MP:0005397 10.01 CDKN2A CTTN ENG KDR NOTCH1 SERPINB5
6 integument MP:0010771 9.91 CDKN2A ENG KDR NOTCH1 RECK STAT3
7 mortality/aging MP:0010768 9.91 CDKN2A CTTN ENG KDR NOTCH1 RECK
8 craniofacial MP:0005382 9.88 ENG KDR NOTCH1 STAT3 TP53
9 liver/biliary system MP:0005370 9.8 CDKN2A KDR NOTCH1 RECK STAT3 TP53
10 muscle MP:0005369 9.63 CDKN2A ENG KDR NOTCH1 STAT3 TP53
11 normal MP:0002873 9.43 ENG KDR NOTCH1 SERPINB5 STAT3 TP53
12 respiratory system MP:0005388 9.17 CDKN2A CTTN ENG KDR NOTCH1 STAT3

Drugs & Therapeutics for Bone Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Bone Squamous Cell Carcinoma

Genetic Tests for Bone Squamous Cell Carcinoma

Anatomical Context for Bone Squamous Cell Carcinoma

MalaCards organs/tissues related to Bone Squamous Cell Carcinoma:

42
Bone, Tongue, Cervix, Breast, Lung, Brain, Spinal Cord

Publications for Bone Squamous Cell Carcinoma

Articles related to Bone Squamous Cell Carcinoma:

# Title Authors Year
1
Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma. ( 27488595 )
2017
2
Survival impact of local extension sites in surgically treated patients with temporal bone squamous cell carcinoma. ( 28044211 )
2017
3
Dramatic response of CTNNB1 and VEGFR-2 mutant temporal bone squamous cell carcinoma to bevacizumab in combination with pemetrexed. ( 28915721 )
2017
4
Survival outcomes of patients with temporal bone squamous cell carcinoma with different invasion patterns. ( 24347537 )
2015
5
Temporal bone squamous cell carcinoma - Penang experience. ( 26988214 )
2015
6
Temporal bone squamous cell carcinoma: analyzing prognosis with univariate and multivariate models. ( 24108656 )
2014
7
Evaluation of the prognostic role of pSTAT3 expression in temporal bone squamous cell carcinoma. ( 24005169 )
2013
8
A case of skull base mucormycosis with osteomyelitis secondary to temporal bone squamous cell carcinoma. ( 17240707 )
2006

Variations for Bone Squamous Cell Carcinoma

Expression for Bone Squamous Cell Carcinoma

Search GEO for disease gene expression data for Bone Squamous Cell Carcinoma.

Pathways for Bone Squamous Cell Carcinoma

GO Terms for Bone Squamous Cell Carcinoma

Cellular components related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 ENG KDR NOTCH1

Biological processes related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 CDKN2A ENG NOTCH1 STAT3 TP53
2 positive regulation of transcription, DNA-templated GO:0045893 9.92 CDKN2A NOTCH1 STAT3 TP53
3 negative regulation of cell proliferation GO:0008285 9.88 CDKN2A NOTCH1 STAT3 TP53
4 positive regulation of cell migration GO:0030335 9.8 KDR NOTCH1 STAT3
5 extracellular matrix organization GO:0030198 9.78 KDR RECK SERPINB5
6 cell cycle arrest GO:0007050 9.75 CDKN2A NOTCH1 TP53
7 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.62 KDR NOTCH1
8 positive regulation of BMP signaling pathway GO:0030513 9.61 ENG NOTCH1
9 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.6 STAT3 TP53
10 endocardial cushion morphogenesis GO:0003203 9.57 ENG NOTCH1
11 ventricular trabecula myocardium morphogenesis GO:0003222 9.56 ENG NOTCH1
12 regulation of epithelial cell proliferation GO:0050678 9.55 NOTCH1 SERPINB5
13 negative regulation of stem cell differentiation GO:2000737 9.54 NOTCH1 STAT3
14 replicative senescence GO:0090399 9.52 CDKN2A TP53
15 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.51 ENG NOTCH1
16 regulation of mitochondrial membrane permeability GO:0046902 9.49 STAT3 TP53
17 cardiac ventricle morphogenesis GO:0003208 9.48 ENG NOTCH1
18 somatic stem cell division GO:0048103 9.46 CDKN2A NOTCH1
19 positive regulation of angiogenesis GO:0045766 9.46 ENG KDR RLN2 STAT3
20 astrocyte differentiation GO:0048708 9.43 NOTCH1 STAT3
21 cardiac atrium morphogenesis GO:0003209 9.4 ENG NOTCH1
22 response to corticosteroid GO:0031960 9.37 ENG NOTCH1
23 venous blood vessel morphogenesis GO:0048845 9.32 ENG NOTCH1
24 cell migration involved in endocardial cushion formation GO:0003273 9.26 ENG NOTCH1
25 sprouting angiogenesis GO:0002040 9.13 ENG NOTCH1 RECK
26 positive regulation of gene expression GO:0010628 9.1 CDKN2A ENG NOTCH1 RLN2 STAT3 TP53

Molecular functions related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 9.16 CDKN2A TP53
2 transmembrane signaling receptor activity GO:0004888 8.96 ENG NOTCH1
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.8 NOTCH1 STAT3 TP53

Sources for Bone Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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