MCID: BNS004
MIFTS: 33

Bone Squamous Cell Carcinoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Squamous Cell Carcinoma

MalaCards integrated aliases for Bone Squamous Cell Carcinoma:

Name: Bone Squamous Cell Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050896

Summaries for Bone Squamous Cell Carcinoma

Disease Ontology : 12 A bone carcinoma that derives from squamous epithelial cells.

MalaCards based summary : Bone Squamous Cell Carcinoma is related to squamous cell carcinoma and bone cancer. An important gene associated with Bone Squamous Cell Carcinoma is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. Affiliated tissues include bone, and related phenotypes are Reduced mammosphere formation and Decreased cell migration

Related Diseases for Bone Squamous Cell Carcinoma

Diseases related to Bone Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 259)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 28.5 TP53 STAT3 NOTCH1 MMP9 EGFR CTTN
2 bone cancer 27.0 TP53 SERPINB5 RLN2 RECK NOTCH1 MMP9
3 prostate squamous cell carcinoma 10.4 TP53 CDKN2A
4 endometrial squamous cell carcinoma 10.4 TP53 CDKN2A
5 middle ear squamous cell carcinoma 10.3 RECK MMP9
6 ovarian seromucinous carcinoma 10.3 TP53 CDKN2A
7 splenic diffuse red pulp small b-cell lymphoma 10.3 TP53 NOTCH1
8 esophageal leukoplakia 10.3 TP53 CCND1
9 adult teratoma 10.3 TP53 ENG
10 bowenoid papulosis 10.3 CDKN2A CCND1
11 spitz nevus 10.3 TP53 CDKN2A
12 angiokeratoma of mibelli 10.3 MMP9 KDR
13 pancreatic foamy gland adenocarcinoma 10.3 TP53 CCND1
14 bizarre leiomyoma 10.3 TP53 CDKN2A
15 squamous cell papilloma 10.3 TP53 CDKN2A
16 penile benign neoplasm 10.3 TP53 CDKN2A
17 auditory system cancer 10.3 RLN2 RECK MMP9
18 malignant peritoneal mesothelioma 10.2 EGFR CDKN2A
19 central nervous system lymphoma 10.2 TP53 STAT3 CDKN2A
20 intratubular embryonal carcinoma 10.2 TP53 MMP9
21 gallbladder adenoma 10.2 CTNNB1 CDKN2A
22 microcystic stromal tumor 10.2 CTNNB1 CCND1
23 suppressor of tumorigenicity 3 10.2 TP53 CDKN2A
24 tonsil squamous cell carcinoma 10.2 CDKN2A CCND1
25 vascular cancer 10.2 TP53 KDR ENG
26 esophageal basaloid squamous cell carcinoma 10.2 TP53 EGFR
27 cervix carcinoma 10.1 TP53 STAT3 CDKN2A
28 cheilitis 10.1 TP53 STAT3 MMP9
29 atypical polypoid adenomyoma 10.1 CTNNB1 CDKN2A
30 plasmablastic lymphoma 10.1 NOTCH1 CDKN2A
31 nodular malignant melanoma 10.1 TP53 CDKN2A CCND1
32 liver benign neoplasm 10.1 TP53 STAT3 CTNNB1
33 frontal lobe neoplasm 10.1 TP53 EGFR
34 rhabdoid cancer 10.1 TP53 CDKN2A CCND1
35 polymorphous low-grade adenocarcinoma 10.1 SERPINB5 CTNNB1 CCND1
36 vulvar intraepithelial neoplasia 10.1 TP53 CTNNB1 CDKN2A
37 serous cystadenocarcinoma 10.1 TP53 CTNNB1 CDKN2A
38 oral submucous fibrosis 10.1 TP53 MMP9 ENG
39 localized osteosarcoma 10.1 TP53 CDKN2A
40 lymphoblastic lymphoma 10.1 TP53 NOTCH1 CDKN2A
41 mixed lacrimal gland cancer 10.1 TYK2 STAT3 CCND1
42 papillary squamous carcinoma 10.1 EGFR CDKN2A
43 glandular cystitis 10.1 TP53 CTNNB1
44 endocervical carcinoma 10.1 TP53 CTNNB1 CDKN2A
45 soft tissue sarcoma 10.1 TP53 EGFR
46 alk-positive anaplastic large cell lymphoma 10.0 STAT3 JAK3
47 keratocystic odontogenic tumor 10.0 TP53 MMP9 CCND1
48 keratinizing squamous cell carcinoma 10.0 TP53 EGFR CDKN2A
49 vulvar disease 10.0 TP53 EGFR CDKN2A
50 laryngeal disease 10.0 TP53 CDKN2A CCND1

Graphical network of the top 20 diseases related to Bone Squamous Cell Carcinoma:



Diseases related to Bone Squamous Cell Carcinoma

Symptoms & Phenotypes for Bone Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CCND1 EGFR JAK3 KDR NOTCH1 RECK
2 Decreased cell migration GR00055-A-3 8.65 EGFR

MGI Mouse Phenotypes related to Bone Squamous Cell Carcinoma:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.43 CCND1 CDKN2A CTNNB1 CTTN EGFR JAK3
2 cardiovascular system MP:0005385 10.4 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
3 growth/size/body region MP:0005378 10.39 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
4 hematopoietic system MP:0005397 10.38 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
5 mortality/aging MP:0010768 10.35 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
6 embryo MP:0005380 10.3 CDKN2A CTNNB1 CTTN EGFR ENG KDR
7 immune system MP:0005387 10.3 CCND1 CDKN2A CTNNB1 CTTN EGFR JAK3
8 digestive/alimentary MP:0005381 10.27 CCND1 CDKN2A CTNNB1 EGFR ENG JAK3
9 integument MP:0010771 10.25 CCND1 CDKN2A CTNNB1 EGFR ENG KDR
10 craniofacial MP:0005382 10.18 CCND1 CTNNB1 EGFR ENG KDR NOTCH1
11 nervous system MP:0003631 10.18 CCND1 CDKN2A CTNNB1 EGFR ENG KDR
12 muscle MP:0005369 10.11 CDKN2A CTNNB1 EGFR ENG KDR MMP9
13 liver/biliary system MP:0005370 10.1 CDKN2A CTNNB1 EGFR KDR NOTCH1 RECK
14 neoplasm MP:0002006 10.03 CCND1 CDKN2A CTNNB1 EGFR MMP9 NOTCH1
15 normal MP:0002873 9.97 CCND1 CTNNB1 EGFR ENG KDR NOTCH1
16 no phenotypic analysis MP:0003012 9.91 CDKN2A CTNNB1 CTTN EGFR KDR SERPINB5
17 respiratory system MP:0005388 9.9 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
18 pigmentation MP:0001186 9.73 CDKN2A CTNNB1 EGFR JAK3 NOTCH1 TP53
19 skeleton MP:0005390 9.7 CCND1 CDKN2A CTNNB1 EGFR KDR MMP9
20 vision/eye MP:0005391 9.32 CCND1 CDKN2A CTNNB1 EGFR JAK3 KDR

Drugs & Therapeutics for Bone Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Bone Squamous Cell Carcinoma

Genetic Tests for Bone Squamous Cell Carcinoma

Anatomical Context for Bone Squamous Cell Carcinoma

MalaCards organs/tissues related to Bone Squamous Cell Carcinoma:

40
Bone

Publications for Bone Squamous Cell Carcinoma

Articles related to Bone Squamous Cell Carcinoma:

(show all 25)
# Title Authors PMID Year
1
Therapeutic effect of Nivolumab for advanced / recurrent temporal bone squamous cell carcinoma. 61
32446629 2020
2
Primary Advanced Squamous Cell Carcinoma of the Temporal Bone: A Single-Center Clinical Study. 61
32267551 2020
3
Squamous cell carcinoma of the temporal bone: A current review. 61
31890889 2019
4
Dramatic response of CTNNB1 and VEGFR-2 mutant temporal bone squamous cell carcinoma to bevacizumab in combination with pemetrexed. 61
28915721 2017
5
Survival impact of local extension sites in surgically treated patients with temporal bone squamous cell carcinoma. 61
28044211 2017
6
Cortactin and phosphorylated cortactin tyr466 expression in temporal bone carcinoma. 61
28131549 2017
7
Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma. 61
27488595 2017
8
Temporal bone carcinoma: a first glance beyond the conventional clinical and pathological prognostic factors. 61
26518208 2016
9
Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence. 61
27330424 2016
10
Clinical and pathological parameters prognostic for increased risk of recurrence after postoperative radiotherapy for temporal bone carcinoma. 61
26348213 2016
11
Temporal bone squamous cell carcinoma - Penang experience. 61
26988214 2015
12
A critical look at persistent problems in the diagnosis, staging and treatment of temporal bone carcinoma. 61
26549119 2015
13
Relaxin-2 expression in temporal bone carcinoma. 61
25388992 2015
14
Recurrent squamous cell carcinoma of the temporal bone: critical analysis of cases with a poor prognosis. 61
25595048 2015
15
Survival outcomes of patients with temporal bone squamous cell carcinoma with different invasion patterns. 61
24347537 2015
16
Temporal bone squamous cell carcinoma: analyzing prognosis with univariate and multivariate models. 61
24108656 2014
17
Evaluation of the prognostic role of pSTAT3 expression in temporal bone squamous cell carcinoma. 61
24005169 2013
18
[The clinical analysis and treatment of facial paralysis caused by temporal bone tumors]. 61
24260866 2013
19
Expression of the tumour-suppressor maspin in temporal bone carcinoma. 61
23730906 2013
20
Neoangiogenesis in temporal bone carcinoma: the prognostic role of CD105. 61
22643443 2012
21
The problem of nodal disease in squamous cell carcinoma of the temporal bone. 61
20524790 2010
22
Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. 61
19381105 2009
23
Squamous cell carcinoma of the temporal bone: results and management. 61
18520589 2008
24
A case of skull base mucormycosis with osteomyelitis secondary to temporal bone squamous cell carcinoma. 61
17240707 2006
25
Metastatic squamous cell carcinoma of the conjunctiva. 61
3173999 1988

Variations for Bone Squamous Cell Carcinoma

Expression for Bone Squamous Cell Carcinoma

Search GEO for disease gene expression data for Bone Squamous Cell Carcinoma.

Pathways for Bone Squamous Cell Carcinoma

Pathways related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.17 TYK2 TP53 STAT3 RLN2 NOTCH1 MMP9
2
Show member pathways
13.82 TP53 STAT3 NOTCH1 KDR JAK3 EGFR
3
Show member pathways
13.69 TP53 STAT3 NOTCH1 MMP9 KDR JAK3
4
Show member pathways
13.36 TYK2 TP53 STAT3 MMP9 JAK3 EGFR
5
Show member pathways
12.98 TYK2 TP53 STAT3 MMP9 JAK3 EGFR
6
Show member pathways
12.9 TYK2 TP53 STAT3 EGFR CTNNB1 CDKN2A
7
Show member pathways
12.89 STAT3 KDR EGFR CTNNB1 CCND1
8
Show member pathways
12.89 TYK2 TP53 NOTCH1 KDR JAK3 EGFR
9
Show member pathways
12.84 TP53 STAT3 MMP9 EGFR CTNNB1 CDKN2A
10
Show member pathways
12.82 TYK2 TP53 STAT3 JAK3 CCND1
11
Show member pathways
12.75 TP53 NOTCH1 EGFR CTNNB1 CDKN2A CCND1
12
Show member pathways
12.63 TP53 STAT3 KDR EGFR CCND1
13
Show member pathways
12.59 TYK2 TP53 STAT3 EGFR CTNNB1
14 12.53 TP53 STAT3 NOTCH1 MMP9 JAK3 EGFR
15
Show member pathways
12.52 TP53 STAT3 NOTCH1 MMP9 JAK3 EGFR
16
Show member pathways
12.5 TP53 STAT3 KDR EGFR CTNNB1
17
Show member pathways
12.47 TYK2 STAT3 JAK3 EGFR CCND1
18
Show member pathways
12.44 TP53 KDR EGFR CTNNB1
19
Show member pathways
12.4 STAT3 KDR JAK3 CTNNB1
20
Show member pathways
12.39 TYK2 TP53 STAT3 JAK3 CCND1
21
Show member pathways
12.38 TP53 SERPINB5 CDKN2A CCND1
22 12.35 TP53 JAK3 CDKN2A CCND1
23
Show member pathways
12.3 TP53 STAT3 EGFR CTNNB1 CCND1
24
Show member pathways
12.29 TYK2 TP53 STAT3 JAK3 EGFR
25 12.28 TP53 STAT3 JAK3 CDKN2A CCND1
26 12.16 TP53 EGFR CTNNB1 CCND1
27
Show member pathways
12.11 TYK2 STAT3 JAK3
28 12.1 TP53 MMP9 KDR CTNNB1
29 12.1 TP53 STAT3 MMP9 EGFR CTNNB1 CCND1
30 12.03 TP53 NOTCH1 CTNNB1 CCND1
31 12.01 TP53 MMP9 EGFR CCND1
32 11.98 TP53 CTNNB1 CDKN2A CCND1
33 11.92 TP53 EGFR CTNNB1 CDKN2A CCND1
34 11.9 TYK2 TP53 STAT3 MMP9 JAK3 CCND1
35 11.87 TP53 STAT3 MMP9 KDR EGFR CTTN
36 11.86 STAT3 EGFR CTNNB1 CCND1
37
Show member pathways
11.85 TYK2 STAT3 JAK3
38 11.79 MMP9 CTNNB1 CCND1
39 11.77 TP53 STAT3 SERPINB5 RECK NOTCH1 MMP9
40 11.72 TP53 KDR CTNNB1 CDKN2A
41 11.7 STAT3 MMP9 EGFR
42 11.69 TP53 MMP9 EGFR CDKN2A CCND1
43 11.68 SERPINB5 RECK NOTCH1 MMP9 KDR ENG
44 11.63 STAT3 ENG CTNNB1
45
Show member pathways
11.62 STAT3 MMP9 EGFR CCND1
46 11.56 TYK2 STAT3 EGFR
47 11.54 STAT3 NOTCH1 KDR
48 11.54 TP53 EGFR CDKN2A CCND1
49 11.53 TP53 STAT3 CTTN CCND1
50 11.52 NOTCH1 CTNNB1 CCND1

GO Terms for Bone Squamous Cell Carcinoma

Cellular components related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Wnt signalosome GO:1990909 8.96 RECK CTNNB1
2 receptor complex GO:0043235 8.92 NOTCH1 KDR ENG EGFR

Biological processes related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.15 TP53 STAT3 NOTCH1 ENG EGFR CTNNB1
2 viral process GO:0016032 10.09 TP53 STAT3 KDR EGFR CTNNB1
3 negative regulation of apoptotic process GO:0043066 10.08 TP53 MMP9 KDR EGFR CTNNB1
4 phosphorylation GO:0016310 10.07 TYK2 STAT3 KDR JAK3 EGFR CDKN2A
5 negative regulation of cell proliferation GO:0008285 10.03 TP53 STAT3 NOTCH1 CTNNB1 CDKN2A
6 positive regulation of transcription, DNA-templated GO:0045893 10.01 TP53 STAT3 NOTCH1 EGFR CTNNB1 CDKN2A
7 positive regulation of apoptotic process GO:0043065 9.98 TP53 NOTCH1 MMP9 CTNNB1 CDKN2A
8 extracellular matrix organization GO:0030198 9.97 SERPINB5 RECK MMP9 KDR
9 heart development GO:0007507 9.97 TP53 NOTCH1 ENG CTNNB1
10 response to drug GO:0042493 9.89 TP53 STAT3 ENG CTNNB1 CCND1
11 lung development GO:0030324 9.88 NOTCH1 EGFR CTNNB1
12 positive regulation of cell proliferation GO:0008284 9.88 STAT3 NOTCH1 KDR EGFR CTNNB1 CCND1
13 liver development GO:0001889 9.86 NOTCH1 EGFR CCND1
14 positive regulation of angiogenesis GO:0045766 9.85 STAT3 RLN2 KDR ENG
15 negative regulation of gene expression GO:0010629 9.85 TP53 NOTCH1 KDR ENG CTNNB1
16 peptidyl-tyrosine phosphorylation GO:0018108 9.83 TYK2 KDR JAK3 EGFR
17 vasculogenesis GO:0001570 9.81 KDR ENG CTNNB1
18 positive regulation of epithelial cell proliferation GO:0050679 9.81 NOTCH1 EGFR CCND1
19 epithelial to mesenchymal transition GO:0001837 9.75 NOTCH1 ENG CTNNB1
20 positive regulation of cell migration GO:0030335 9.72 STAT3 NOTCH1 MMP9 KDR EGFR
21 cardiac septum morphogenesis GO:0060411 9.71 TP53 NOTCH1
22 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.71 STAT3 JAK3
23 replicative senescence GO:0090399 9.7 TP53 CDKN2A
24 negative regulation of oligodendrocyte differentiation GO:0048715 9.7 NOTCH1 CTNNB1
25 interleukin-15-mediated signaling pathway GO:0035723 9.7 STAT3 JAK3
26 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.69 NOTCH1 ENG
27 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.68 TP53 EGFR
28 interleukin-27-mediated signaling pathway GO:0070106 9.68 TYK2 STAT3
29 response to leptin GO:0044321 9.68 STAT3 CCND1
30 somatic stem cell division GO:0048103 9.67 NOTCH1 CDKN2A
31 response to estradiol GO:0032355 9.67 STAT3 EGFR CTNNB1 CCND1
32 cardiac ventricle morphogenesis GO:0003208 9.66 NOTCH1 ENG
33 interleukin-23-mediated signaling pathway GO:0038155 9.66 TYK2 STAT3
34 interleukin-9-mediated signaling pathway GO:0038113 9.65 STAT3 JAK3
35 astrocyte differentiation GO:0048708 9.65 STAT3 NOTCH1
36 interleukin-21-mediated signaling pathway GO:0038114 9.65 STAT3 JAK3
37 sprouting angiogenesis GO:0002040 9.65 NOTCH1 KDR ENG
38 regulation of cell proliferation GO:0042127 9.65 TP53 STAT3 NOTCH1 EGFR CTNNB1
39 mitotic G1 DNA damage checkpoint GO:0031571 9.64 TP53 CCND1
40 venous blood vessel morphogenesis GO:0048845 9.62 NOTCH1 ENG
41 response to corticosteroid GO:0031960 9.62 NOTCH1 ENG
42 cardiac atrium morphogenesis GO:0003209 9.61 NOTCH1 ENG
43 branching involved in blood vessel morphogenesis GO:0001569 9.61 KDR ENG CTNNB1
44 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.6 TP53 NOTCH1
45 central nervous system vasculogenesis GO:0022009 9.57 ENG CTNNB1
46 cell migration involved in endocardial cushion formation GO:0003273 9.56 NOTCH1 ENG
47 positive regulation of protein phosphorylation GO:0001934 9.55 MMP9 KDR ENG EGFR CCND1
48 response to UV-A GO:0070141 9.51 EGFR CCND1
49 cytokine-mediated signaling pathway GO:0019221 9.43 TYK2 TP53 STAT3 MMP9 JAK3 CCND1
50 positive regulation of gene expression GO:0010628 9.17 TP53 STAT3 RLN2 NOTCH1 ENG CTNNB1

Molecular functions related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.88 TYK2 KDR JAK3 EGFR CDKN2A CCND1
2 protein kinase activity GO:0004672 9.83 TYK2 KDR JAK3 EGFR CCND1
3 transcription factor binding GO:0008134 9.77 TP53 STAT3 CTNNB1 CDKN2A CCND1
4 protein kinase binding GO:0019901 9.63 TP53 STAT3 EGFR CTNNB1 CDKN2A CCND1
5 protein tyrosine kinase activity GO:0004713 9.56 TYK2 KDR JAK3 EGFR
6 disordered domain specific binding GO:0097718 9.5 TP53 CTNNB1 CDKN2A
7 enzyme binding GO:0019899 9.43 TP53 NOTCH1 EGFR CYP2C19 CTNNB1 CCND1
8 protein phosphatase binding GO:0019903 9.02 TP53 STAT3 JAK3 EGFR CTNNB1

Sources for Bone Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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