MCID: BNS004
MIFTS: 29

Bone Squamous Cell Carcinoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Squamous Cell Carcinoma

MalaCards integrated aliases for Bone Squamous Cell Carcinoma:

Name: Bone Squamous Cell Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050896

Summaries for Bone Squamous Cell Carcinoma

Disease Ontology : 12 A bone carcinoma that derives from squamous epithelial cells.

MalaCards based summary : Bone Squamous Cell Carcinoma is related to squamous cell carcinoma and bone cancer. An important gene associated with Bone Squamous Cell Carcinoma is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Pathways in cancer and Glioma. Affiliated tissues include bone, and related phenotypes are cardiovascular system and embryo

Related Diseases for Bone Squamous Cell Carcinoma

Diseases related to Bone Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 87)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 29.8 TP53 NOTCH1 CTTN CDKN2A
2 bone cancer 28.0 RLN2 RECK NOTCH1 ENG CDKN2A
3 skin carcinoma in situ 10.5 STAT3 CDKN2A
4 plasmablastic lymphoma 10.3 NOTCH1 CDKN2A
5 drug-induced lupus erythematosus 10.2 KDR ENG
6 non-proliferative fibrocystic change of the breast 10.2 TP53 ENG
7 bladder squamous cell carcinoma 10.2 TP53 CDKN2A
8 keratinizing squamous cell carcinoma 10.2 TP53 CDKN2A
9 spitz nevus 10.2 TP53 CDKN2A
10 bladder carcinoma in situ 10.2 TP53 CDKN2A
11 scrotal carcinoma 10.2 TP53 CDKN2A
12 vulva squamous cell carcinoma 10.2 TP53 CDKN2A
13 bartholin's gland disease 10.2 TP53 CDKN2A
14 nasal cavity adenocarcinoma 10.2 TP53 CDKN2A
15 vulvar disease 10.2 TP53 CDKN2A
16 thyroid lymphoma 10.2 TP53 CDKN2A
17 splenic diffuse red pulp small b-cell lymphoma 10.2 TP53 NOTCH1
18 anal squamous cell carcinoma 10.1 TP53 CDKN2A
19 invasive bladder transitional cell carcinoma 10.1 TP53 NOTCH1
20 glycogen-rich clear cell breast carcinoma 10.1 TP53 CDKN2A
21 megaesophagus 10.1 TP53 CDKN2A
22 oral leukoplakia 10.1 TP53 CDKN2A
23 uterus carcinoma in situ 10.1 TP53 CDKN2A
24 cervix uteri carcinoma in situ 10.1 TP53 CDKN2A
25 anogenital venereal wart 10.1 TP53 CDKN2A
26 meningeal melanomatosis 10.1 TP53 CDKN2A
27 suppressor of tumorigenicity 3 10.1 TP53 CDKN2A
28 dedifferentiated liposarcoma 10.1 TP53 CDKN2A
29 endocervical adenocarcinoma 10.1 TP53 CDKN2A
30 penile disease 10.1 TP53 CDKN2A
31 cervix small cell carcinoma 10.1 TP53 CDKN2A
32 basaloid squamous cell carcinoma 10.1 TP53 CDKN2A
33 spinal cord astrocytoma 10.1 TP53 NOTCH1
34 verrucous carcinoma 10.1 TP53 CDKN2A
35 cheilitis 10.1 TP53 SERPINB5
36 necrotizing sialometaplasia 10.0 TP53 CDKN2A
37 osteomyelitis 10.0
38 tongue disease 10.0 TP53 CDKN2A
39 optic nerve neoplasm 10.0 TP53 CDKN2A
40 richter's syndrome 10.0 TP53 NOTCH1
41 tonsil cancer 10.0 TP53 CDKN2A
42 juvenile pilocytic astrocytoma 10.0 TP53 CDKN2A
43 gastric adenosquamous carcinoma 10.0 TP53 STAT3 CDKN2A
44 cervix carcinoma 10.0 TP53 STAT3 CDKN2A
45 central nervous system cancer 9.9 TP53 STAT3 CDKN2A
46 respiratory system cancer 9.9 TP53 STAT3 CDKN2A
47 squamous cell papilloma 9.9 TP53 CDKN2A
48 gastrointestinal system disease 9.9 TP53 STAT3 CDKN2A
49 fibrosarcoma of bone 9.9 KDR CDKN2A
50 mantle cell lymphoma 9.9 TP53 STAT3 CDKN2A

Graphical network of the top 20 diseases related to Bone Squamous Cell Carcinoma:



Diseases related to Bone Squamous Cell Carcinoma

Symptoms & Phenotypes for Bone Squamous Cell Carcinoma

MGI Mouse Phenotypes related to Bone Squamous Cell Carcinoma:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.11 CDKN2A CTTN ENG KDR NOTCH1 RECK
2 embryo MP:0005380 10.11 CDKN2A CTTN ENG KDR NOTCH1 RECK
3 cellular MP:0005384 10.1 CDKN2A CTTN KDR NOTCH1 RECK SERPINB5
4 growth/size/body region MP:0005378 10.09 CDKN2A CTTN ENG KDR NOTCH1 RECK
5 hematopoietic system MP:0005397 10.01 CDKN2A CTTN ENG KDR NOTCH1 SERPINB5
6 integument MP:0010771 9.91 CDKN2A ENG KDR NOTCH1 RECK STAT3
7 mortality/aging MP:0010768 9.91 CDKN2A CTTN ENG KDR NOTCH1 RECK
8 craniofacial MP:0005382 9.88 ENG KDR NOTCH1 STAT3 TP53
9 liver/biliary system MP:0005370 9.8 CDKN2A KDR NOTCH1 RECK STAT3 TP53
10 muscle MP:0005369 9.63 CDKN2A ENG KDR NOTCH1 STAT3 TP53
11 normal MP:0002873 9.43 ENG KDR NOTCH1 SERPINB5 STAT3 TP53
12 respiratory system MP:0005388 9.17 CDKN2A CTTN ENG KDR NOTCH1 STAT3

Drugs & Therapeutics for Bone Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Bone Squamous Cell Carcinoma

Genetic Tests for Bone Squamous Cell Carcinoma

Anatomical Context for Bone Squamous Cell Carcinoma

MalaCards organs/tissues related to Bone Squamous Cell Carcinoma:

41
Bone

Publications for Bone Squamous Cell Carcinoma

Articles related to Bone Squamous Cell Carcinoma:

(show all 22)
# Title Authors PMID Year
1
Dramatic response of CTNNB1 and VEGFR-2 mutant temporal bone squamous cell carcinoma to bevacizumab in combination with pemetrexed. 38
28915721 2017
2
Survival impact of local extension sites in surgically treated patients with temporal bone squamous cell carcinoma. 38
28044211 2017
3
Cortactin and phosphorylated cortactin tyr466 expression in temporal bone carcinoma. 38
28131549 2017
4
Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma. 38
27488595 2017
5
Temporal bone carcinoma: a first glance beyond the conventional clinical and pathological prognostic factors. 38
26518208 2016
6
Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence. 38
27330424 2016
7
Clinical and pathological parameters prognostic for increased risk of recurrence after postoperative radiotherapy for temporal bone carcinoma. 38
26348213 2016
8
Temporal bone squamous cell carcinoma - Penang experience. 38
26988214 2015
9
A critical look at persistent problems in the diagnosis, staging and treatment of temporal bone carcinoma. 38
26549119 2015
10
Relaxin-2 expression in temporal bone carcinoma. 38
25388992 2015
11
Recurrent squamous cell carcinoma of the temporal bone: critical analysis of cases with a poor prognosis. 38
25595048 2015
12
Survival outcomes of patients with temporal bone squamous cell carcinoma with different invasion patterns. 38
24347537 2015
13
Temporal bone squamous cell carcinoma: analyzing prognosis with univariate and multivariate models. 38
24108656 2014
14
Evaluation of the prognostic role of pSTAT3 expression in temporal bone squamous cell carcinoma. 38
24005169 2013
15
[The clinical analysis and treatment of facial paralysis caused by temporal bone tumors]. 38
24260866 2013
16
Expression of the tumour-suppressor maspin in temporal bone carcinoma. 38
23730906 2013
17
Neoangiogenesis in temporal bone carcinoma: the prognostic role of CD105. 38
22643443 2012
18
The problem of nodal disease in squamous cell carcinoma of the temporal bone. 38
20524790 2010
19
Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. 38
19381105 2009
20
Squamous cell carcinoma of the temporal bone: results and management. 38
18520589 2008
21
A case of skull base mucormycosis with osteomyelitis secondary to temporal bone squamous cell carcinoma. 38
17240707 2006
22
Metastatic squamous cell carcinoma of the conjunctiva. 38
3173999 1988

Variations for Bone Squamous Cell Carcinoma

Expression for Bone Squamous Cell Carcinoma

Search GEO for disease gene expression data for Bone Squamous Cell Carcinoma.

Pathways for Bone Squamous Cell Carcinoma

GO Terms for Bone Squamous Cell Carcinoma

Cellular components related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.8 NOTCH1 KDR ENG

Biological processes related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.99 TP53 STAT3 NOTCH1 ENG CDKN2A
2 positive regulation of transcription, DNA-templated GO:0045893 9.92 TP53 STAT3 NOTCH1 CDKN2A
3 negative regulation of cell proliferation GO:0008285 9.88 TP53 STAT3 NOTCH1 CDKN2A
4 positive regulation of cell migration GO:0030335 9.8 STAT3 NOTCH1 KDR
5 extracellular matrix organization GO:0030198 9.78 SERPINB5 RECK KDR
6 cell cycle arrest GO:0007050 9.75 TP53 NOTCH1 CDKN2A
7 positive regulation of BMP signaling pathway GO:0030513 9.62 NOTCH1 ENG
8 cellular response to vascular endothelial growth factor stimulus GO:0035924 9.61 NOTCH1 KDR
9 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.6 TP53 STAT3
10 endocardial cushion morphogenesis GO:0003203 9.57 NOTCH1 ENG
11 ventricular trabecula myocardium morphogenesis GO:0003222 9.56 NOTCH1 ENG
12 regulation of epithelial cell proliferation GO:0050678 9.55 SERPINB5 NOTCH1
13 negative regulation of stem cell differentiation GO:2000737 9.54 STAT3 NOTCH1
14 replicative senescence GO:0090399 9.52 TP53 CDKN2A
15 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.51 NOTCH1 ENG
16 regulation of mitochondrial membrane permeability GO:0046902 9.49 TP53 STAT3
17 somatic stem cell division GO:0048103 9.48 NOTCH1 CDKN2A
18 cardiac ventricle morphogenesis GO:0003208 9.46 NOTCH1 ENG
19 positive regulation of angiogenesis GO:0045766 9.46 STAT3 RLN2 KDR ENG
20 astrocyte differentiation GO:0048708 9.43 STAT3 NOTCH1
21 venous blood vessel morphogenesis GO:0048845 9.4 NOTCH1 ENG
22 response to corticosteroid GO:0031960 9.37 NOTCH1 ENG
23 cardiac atrium morphogenesis GO:0003209 9.32 NOTCH1 ENG
24 cell migration involved in endocardial cushion formation GO:0003273 9.26 NOTCH1 ENG
25 sprouting angiogenesis GO:0002040 9.13 RECK NOTCH1 ENG
26 positive regulation of gene expression GO:0010628 9.1 TP53 STAT3 RLN2 NOTCH1 ENG CDKN2A

Molecular functions related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 disordered domain specific binding GO:0097718 9.16 TP53 CDKN2A
2 transmembrane signaling receptor activity GO:0004888 8.96 NOTCH1 ENG
3 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 8.8 TP53 STAT3 NOTCH1

Sources for Bone Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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