MCID: BNS004
MIFTS: 33

Bone Squamous Cell Carcinoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Squamous Cell Carcinoma

MalaCards integrated aliases for Bone Squamous Cell Carcinoma:

Name: Bone Squamous Cell Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050896

Summaries for Bone Squamous Cell Carcinoma

Disease Ontology : 12 A bone carcinoma that derives from squamous epithelial cells.

MalaCards based summary : Bone Squamous Cell Carcinoma is related to squamous cell carcinoma and auditory system cancer. An important gene associated with Bone Squamous Cell Carcinoma is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. Affiliated tissues include bone, and related phenotypes are Reduced mammosphere formation and Decreased cell migration

Related Diseases for Bone Squamous Cell Carcinoma

Diseases related to Bone Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 29.2 TP53 STAT3 NOTCH1 MMP9 EGFR CTTN
2 auditory system cancer 10.4 RLN2 RECK
3 adult teratoma 10.3 TP53 ENG
4 middle ear squamous cell carcinoma 10.3 RECK MMP9
5 ovarian seromucinous carcinoma 10.3 TP53 CDKN2A
6 human papillomavirus infectious disease 10.3 TP53 CDKN2A
7 esophageal leukoplakia 10.3 TP53 CCND1
8 splenic diffuse red pulp small b-cell lymphoma 10.3 TP53 NOTCH1
9 bowenoid papulosis 10.3 CDKN2A CCND1
10 spitz nevus 10.3 TP53 CDKN2A
11 angiokeratoma of mibelli 10.3 MMP9 KDR
12 mixed lacrimal gland cancer 10.2 TYK2 STAT3
13 squamous cell papilloma 10.2 TP53 CDKN2A
14 penile benign neoplasm 10.2 TP53 CDKN2A
15 pancreatic foamy gland adenocarcinoma 10.2 TP53 CCND1
16 bizarre leiomyoma 10.2 TP53 CDKN2A
17 tonsil squamous cell carcinoma 10.2 CDKN2A CCND1
18 gallbladder adenoma 10.2 CTNNB1 CDKN2A
19 adult malignant schwannoma 10.2 TP53 CDKN2A
20 malignant peritoneal mesothelioma 10.2 EGFR CDKN2A
21 intratubular embryonal carcinoma 10.2 TP53 MMP9
22 microcystic stromal tumor 10.2 CTNNB1 CCND1
23 suppressor of tumorigenicity 3 10.2 TP53 CDKN2A
24 papillary squamous carcinoma 10.2 EGFR CDKN2A
25 vascular cancer 10.1 TP53 KDR ENG
26 esophageal basaloid squamous cell carcinoma 10.1 TP53 EGFR
27 angiokeratoma circumscriptum 10.1 MMP9 KDR
28 cheilitis 10.1 TP53 STAT3 MMP9
29 frontal lobe neoplasm 10.1 TP53 EGFR
30 nodular malignant melanoma 10.1 TP53 CDKN2A CCND1
31 atypical polypoid adenomyoma 10.1 CTNNB1 CDKN2A
32 liver benign neoplasm 10.1 TP53 STAT3 CTNNB1
33 keratosis 10.1 TP53 MMP9 CDKN2A
34 middle ear carcinoma 10.1 RECK MMP9
35 localized osteosarcoma 10.1 TP53 CDKN2A
36 polymorphous low-grade adenocarcinoma 10.1 SERPINB5 CTNNB1 CCND1
37 oral submucous fibrosis 10.1 TP53 MMP9 ENG
38 spinal cord oligodendroglioma 10.1 TP53 EGFR
39 vulvar intraepithelial neoplasia 10.1 TP53 CTNNB1 CDKN2A
40 malignant exocrine pancreas neoplasm 10.1 TP53 CDKN2A
41 rhabdoid cancer 10.1 TP53 CDKN2A CCND1
42 soft tissue sarcoma 10.1 TP53 EGFR
43 endocervical carcinoma 10.1 TP53 CTNNB1 CDKN2A
44 alk-positive anaplastic large cell lymphoma 10.1 STAT3 JAK3
45 chronic cervicitis 10.1 TP53 CDKN2A
46 keratocystic odontogenic tumor 10.1 TP53 MMP9 CCND1
47 arteriovenous malformations of the brain 10.0 KDR ENG EGFR
48 supraglottis cancer 10.0 TP53 EGFR CDKN2A
49 laryngeal disease 10.0 TP53 CDKN2A CCND1
50 breast malignant phyllodes tumor 10.0 TP53 EGFR

Graphical network of the top 20 diseases related to Bone Squamous Cell Carcinoma:



Diseases related to Bone Squamous Cell Carcinoma

Symptoms & Phenotypes for Bone Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 CCND1 EGFR JAK3 KDR NOTCH1 RECK
2 Decreased cell migration GR00055-A-3 8.65 EGFR

MGI Mouse Phenotypes related to Bone Squamous Cell Carcinoma:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.44 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
2 cellular MP:0005384 10.43 CCND1 CDKN2A CTNNB1 CTTN EGFR JAK3
3 behavior/neurological MP:0005386 10.38 CCND1 CDKN2A CTNNB1 CTTN ENG JAK3
4 growth/size/body region MP:0005378 10.36 CCND1 CDKN2A CTNNB1 EGFR ENG KDR
5 hematopoietic system MP:0005397 10.35 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
6 mortality/aging MP:0010768 10.35 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
7 embryo MP:0005380 10.3 CDKN2A CTNNB1 CTTN EGFR ENG KDR
8 immune system MP:0005387 10.3 CCND1 CDKN2A CTNNB1 CTTN EGFR JAK3
9 digestive/alimentary MP:0005381 10.27 CCND1 CDKN2A CTNNB1 EGFR ENG JAK3
10 integument MP:0010771 10.25 CCND1 CDKN2A CTNNB1 EGFR ENG KDR
11 craniofacial MP:0005382 10.18 CCND1 CTNNB1 EGFR ENG KDR NOTCH1
12 nervous system MP:0003631 10.18 CCND1 CDKN2A CTNNB1 EGFR ENG KDR
13 muscle MP:0005369 10.11 CDKN2A CTNNB1 EGFR ENG KDR MMP9
14 liver/biliary system MP:0005370 10.1 CDKN2A CTNNB1 EGFR KDR NOTCH1 RECK
15 neoplasm MP:0002006 10.03 CCND1 CDKN2A CTNNB1 EGFR MMP9 NOTCH1
16 normal MP:0002873 9.97 CCND1 CTNNB1 EGFR ENG KDR NOTCH1
17 no phenotypic analysis MP:0003012 9.91 CDKN2A CTNNB1 CTTN EGFR KDR SERPINB5
18 respiratory system MP:0005388 9.9 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
19 pigmentation MP:0001186 9.73 CDKN2A CTNNB1 EGFR JAK3 NOTCH1 TP53
20 skeleton MP:0005390 9.7 CCND1 CDKN2A CTNNB1 EGFR KDR MMP9
21 vision/eye MP:0005391 9.32 CCND1 CDKN2A CTNNB1 EGFR JAK3 KDR

Drugs & Therapeutics for Bone Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Bone Squamous Cell Carcinoma

Genetic Tests for Bone Squamous Cell Carcinoma

Anatomical Context for Bone Squamous Cell Carcinoma

MalaCards organs/tissues related to Bone Squamous Cell Carcinoma:

40
Bone

Publications for Bone Squamous Cell Carcinoma

Articles related to Bone Squamous Cell Carcinoma:

(show all 30)
# Title Authors PMID Year
1
Primary Advanced Squamous Cell Carcinoma of the Temporal Bone: A Single-Center Clinical Study. 61
32267551 2021
2
Prognostic Significance of Systemic Inflammatory Response in Cases of Temporal Bone Squamous Cell Carcinoma. 61
33538330 2021
3
Temporal bone carcinoma: Novel prognostic score based on clinical and histological features. 61
32851728 2020
4
Therapeutic effect of Nivolumab for advanced / recurrent temporal bone squamous cell carcinoma. 61
32446629 2020
5
Management of squamous cell carcinoma of the temporal bone: long-term results and factors influencing outcomes. 61
32979119 2020
6
Mastoiditis Masquerade. 61
32841094 2020
7
Prognostic Impact of Tumor Extension in Patients With Advanced Temporal Bone Squamous Cell Carcinoma. 61
32850367 2020
8
Squamous cell carcinoma of the temporal bone: A current review. 61
31890889 2019
9
Dramatic response of CTNNB1 and VEGFR-2 mutant temporal bone squamous cell carcinoma to bevacizumab in combination with pemetrexed. 61
28915721 2017
10
Survival impact of local extension sites in surgically treated patients with temporal bone squamous cell carcinoma. 61
28044211 2017
11
Cortactin and phosphorylated cortactin tyr466 expression in temporal bone carcinoma. 61
28131549 2017
12
Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma. 61
27488595 2017
13
Temporal bone carcinoma: a first glance beyond the conventional clinical and pathological prognostic factors. 61
26518208 2016
14
Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence. 61
27330424 2016
15
Clinical and pathological parameters prognostic for increased risk of recurrence after postoperative radiotherapy for temporal bone carcinoma. 61
26348213 2016
16
A critical look at persistent problems in the diagnosis, staging and treatment of temporal bone carcinoma. 61
26549119 2015
17
Temporal bone squamous cell carcinoma - Penang experience. 61
26988214 2015
18
Relaxin-2 expression in temporal bone carcinoma. 61
25388992 2015
19
Recurrent squamous cell carcinoma of the temporal bone: critical analysis of cases with a poor prognosis. 61
25595048 2015
20
Survival outcomes of patients with temporal bone squamous cell carcinoma with different invasion patterns. 61
24347537 2015
21
Temporal bone squamous cell carcinoma: analyzing prognosis with univariate and multivariate models. 61
24108656 2014
22
Evaluation of the prognostic role of pSTAT3 expression in temporal bone squamous cell carcinoma. 61
24005169 2013
23
[The clinical analysis and treatment of facial paralysis caused by temporal bone tumors]. 61
24260866 2013
24
Expression of the tumour-suppressor maspin in temporal bone carcinoma. 61
23730906 2013
25
Neoangiogenesis in temporal bone carcinoma: the prognostic role of CD105. 61
22643443 2012
26
The problem of nodal disease in squamous cell carcinoma of the temporal bone. 61
20524790 2010
27
Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. 61
19381105 2009
28
Squamous cell carcinoma of the temporal bone: results and management. 61
18520589 2008
29
A case of skull base mucormycosis with osteomyelitis secondary to temporal bone squamous cell carcinoma. 61
17240707 2006
30
Metastatic squamous cell carcinoma of the conjunctiva. 61
3173999 1988

Variations for Bone Squamous Cell Carcinoma

Expression for Bone Squamous Cell Carcinoma

Search GEO for disease gene expression data for Bone Squamous Cell Carcinoma.

Pathways for Bone Squamous Cell Carcinoma

Pathways related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.17 TYK2 TP53 STAT3 RLN2 NOTCH1 MMP9
2
Show member pathways
13.82 TP53 STAT3 NOTCH1 KDR JAK3 EGFR
3
Show member pathways
13.69 TP53 STAT3 NOTCH1 MMP9 KDR JAK3
4
Show member pathways
13.36 TYK2 TP53 STAT3 MMP9 JAK3 EGFR
5
Show member pathways
12.98 TYK2 TP53 STAT3 MMP9 JAK3 EGFR
6
Show member pathways
12.9 TYK2 TP53 STAT3 EGFR CTNNB1 CDKN2A
7
Show member pathways
12.89 STAT3 KDR EGFR CTNNB1 CCND1
8
Show member pathways
12.89 TYK2 TP53 NOTCH1 KDR JAK3 EGFR
9
Show member pathways
12.84 TP53 STAT3 MMP9 EGFR CTNNB1 CDKN2A
10
Show member pathways
12.82 TYK2 TP53 STAT3 JAK3 CCND1
11
Show member pathways
12.75 TP53 NOTCH1 EGFR CTNNB1 CDKN2A CCND1
12
Show member pathways
12.63 TP53 STAT3 KDR EGFR CCND1
13
Show member pathways
12.6 TYK2 TP53 STAT3 EGFR CTNNB1
14
Show member pathways
12.53 TP53 STAT3 NOTCH1 MMP9 JAK3 EGFR
15 12.53 TP53 STAT3 NOTCH1 MMP9 JAK3 EGFR
16
Show member pathways
12.51 TP53 STAT3 KDR EGFR CTNNB1
17
Show member pathways
12.44 TP53 KDR EGFR CTNNB1
18
Show member pathways
12.41 TYK2 STAT3 JAK3 EGFR CCND1
19
Show member pathways
12.4 STAT3 KDR JAK3 CTNNB1
20
Show member pathways
12.39 TYK2 TP53 STAT3 JAK3 CCND1
21
Show member pathways
12.38 TP53 SERPINB5 CDKN2A CCND1
22 12.35 TP53 JAK3 CDKN2A CCND1
23
Show member pathways
12.3 TP53 STAT3 EGFR CTNNB1 CCND1
24
Show member pathways
12.29 TYK2 TP53 STAT3 JAK3 EGFR
25 12.28 TP53 STAT3 JAK3 CDKN2A CCND1
26 12.16 TP53 EGFR CTNNB1 CCND1
27 12.11 TP53 MMP9 KDR CTNNB1
28 12.1 TP53 STAT3 MMP9 EGFR CTNNB1 CCND1
29 12.03 TP53 NOTCH1 CTNNB1 CCND1
30 12.02 TP53 MMP9 EGFR CCND1
31 11.98 TP53 CTNNB1 CDKN2A CCND1
32 11.92 TP53 EGFR CTNNB1 CDKN2A CCND1
33 11.9 TYK2 TP53 STAT3 MMP9 JAK3 CCND1
34 11.87 TP53 STAT3 MMP9 KDR EGFR CTTN
35 11.86 STAT3 EGFR CTNNB1 CCND1
36
Show member pathways
11.85 TYK2 STAT3 JAK3
37 11.79 MMP9 CTNNB1 CCND1
38 11.77 TP53 STAT3 SERPINB5 RECK NOTCH1 MMP9
39 11.74 TYK2 STAT3 JAK3
40 11.72 TP53 KDR CTNNB1 CDKN2A
41 11.7 STAT3 MMP9 EGFR
42 11.69 TP53 MMP9 EGFR CDKN2A CCND1
43 11.68 SERPINB5 RECK NOTCH1 MMP9 KDR ENG
44 11.63 STAT3 ENG CTNNB1
45
Show member pathways
11.62 STAT3 MMP9 EGFR CCND1
46 11.56 TYK2 STAT3 EGFR
47 11.54 STAT3 NOTCH1 KDR
48 11.54 TP53 EGFR CDKN2A CCND1
49 11.53 TP53 STAT3 CTTN CCND1
50 11.52 NOTCH1 CTNNB1 CCND1

GO Terms for Bone Squamous Cell Carcinoma

Cellular components related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Wnt signalosome GO:1990909 8.96 RECK CTNNB1
2 receptor complex GO:0043235 8.92 NOTCH1 KDR ENG EGFR

Biological processes related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.15 TP53 STAT3 NOTCH1 ENG EGFR CTNNB1
2 viral process GO:0016032 10.1 TP53 STAT3 KDR EGFR CTNNB1
3 negative regulation of apoptotic process GO:0043066 10.08 TP53 MMP9 KDR EGFR CTNNB1
4 positive regulation of transcription, DNA-templated GO:0045893 10.08 TP53 STAT3 NOTCH1 EGFR CTNNB1 CDKN2A
5 phosphorylation GO:0016310 10.06 TYK2 STAT3 KDR JAK3 EGFR CDKN2A
6 negative regulation of cell proliferation GO:0008285 10.04 TP53 STAT3 NOTCH1 CTNNB1 CDKN2A
7 extracellular matrix organization GO:0030198 9.98 SERPINB5 RECK MMP9 KDR
8 heart development GO:0007507 9.97 TP53 NOTCH1 ENG CTNNB1
9 positive regulation of apoptotic process GO:0043065 9.97 TP53 NOTCH1 MMP9 CTNNB1 CDKN2A
10 negative regulation of transcription by RNA polymerase II GO:0000122 9.95 ZNF77 TP53 STAT3 NOTCH1 ENG CTNNB1
11 positive regulation of cell proliferation GO:0008284 9.93 STAT3 NOTCH1 KDR EGFR CTNNB1 CCND1
12 negative regulation of gene expression GO:0010629 9.91 TP53 NOTCH1 KDR ENG CTNNB1
13 lung development GO:0030324 9.88 NOTCH1 EGFR CTNNB1
14 response to drug GO:0042493 9.88 TP53 STAT3 ENG CTNNB1 CCND1
15 liver development GO:0001889 9.86 NOTCH1 EGFR CCND1
16 positive regulation of angiogenesis GO:0045766 9.85 STAT3 RLN2 KDR ENG
17 peptidyl-tyrosine phosphorylation GO:0018108 9.84 TYK2 KDR JAK3 EGFR
18 vasculogenesis GO:0001570 9.82 KDR ENG CTNNB1
19 epithelial to mesenchymal transition GO:0001837 9.74 NOTCH1 ENG CTNNB1
20 positive regulation of cell migration GO:0030335 9.72 STAT3 NOTCH1 MMP9 KDR EGFR
21 cardiac septum morphogenesis GO:0060411 9.71 TP53 NOTCH1
22 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.71 STAT3 JAK3
23 interleukin-15-mediated signaling pathway GO:0035723 9.7 STAT3 JAK3
24 ventricular trabecula myocardium morphogenesis GO:0003222 9.7 NOTCH1 ENG
25 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.69 TP53 EGFR
26 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.69 NOTCH1 ENG
27 interleukin-27-mediated signaling pathway GO:0070106 9.68 TYK2 STAT3
28 negative regulation of oligodendrocyte differentiation GO:0048715 9.68 NOTCH1 CTNNB1
29 response to leptin GO:0044321 9.67 STAT3 CCND1
30 somatic stem cell division GO:0048103 9.67 NOTCH1 CDKN2A
31 sprouting angiogenesis GO:0002040 9.67 RECK NOTCH1 ENG
32 response to estradiol GO:0032355 9.67 STAT3 EGFR CTNNB1 CCND1
33 interleukin-23-mediated signaling pathway GO:0038155 9.66 TYK2 STAT3
34 interleukin-9-mediated signaling pathway GO:0038113 9.66 STAT3 JAK3
35 mitotic G1 DNA damage checkpoint GO:0031571 9.65 TP53 CCND1
36 cardiac ventricle morphogenesis GO:0003208 9.65 NOTCH1 ENG
37 interleukin-21-mediated signaling pathway GO:0038114 9.65 STAT3 JAK3
38 regulation of cell proliferation GO:0042127 9.65 TP53 STAT3 NOTCH1 ENG CTNNB1
39 astrocyte differentiation GO:0048708 9.63 STAT3 NOTCH1
40 response to corticosteroid GO:0031960 9.63 NOTCH1 ENG
41 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.62 TP53 NOTCH1
42 venous blood vessel morphogenesis GO:0048845 9.62 NOTCH1 ENG
43 cardiac atrium morphogenesis GO:0003209 9.61 NOTCH1 ENG
44 branching involved in blood vessel morphogenesis GO:0001569 9.61 KDR ENG CTNNB1
45 central nervous system vasculogenesis GO:0022009 9.59 ENG CTNNB1
46 cell migration involved in endocardial cushion formation GO:0003273 9.56 NOTCH1 ENG
47 positive regulation of protein phosphorylation GO:0001934 9.55 MMP9 KDR ENG EGFR CCND1
48 response to UV-A GO:0070141 9.52 EGFR CCND1
49 cytokine-mediated signaling pathway GO:0019221 9.43 TYK2 TP53 STAT3 MMP9 JAK3 CCND1
50 positive regulation of gene expression GO:0010628 9.17 TP53 STAT3 RLN2 NOTCH1 ENG CTNNB1

Molecular functions related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.88 TYK2 KDR JAK3 EGFR CDKN2A CCND1
2 protein kinase activity GO:0004672 9.85 TYK2 KDR JAK3 EGFR CCND1
3 transcription factor binding GO:0008134 9.77 TP53 STAT3 CTNNB1 CDKN2A CCND1
4 protein kinase binding GO:0019901 9.63 TP53 STAT3 EGFR CTNNB1 CDKN2A CCND1
5 protein tyrosine kinase activity GO:0004713 9.56 TYK2 KDR JAK3 EGFR
6 disordered domain specific binding GO:0097718 9.5 TP53 CTNNB1 CDKN2A
7 MDM2/MDM4 family protein binding GO:0097371 9.43 TP53 CDKN2A
8 enzyme binding GO:0019899 9.43 TP53 NOTCH1 EGFR CYP2C19 CTNNB1 CCND1
9 protein phosphatase binding GO:0019903 9.02 TP53 STAT3 JAK3 EGFR CTNNB1

Sources for Bone Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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