MCID: BNS004
MIFTS: 35

Bone Squamous Cell Carcinoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Bone Squamous Cell Carcinoma

MalaCards integrated aliases for Bone Squamous Cell Carcinoma:

Name: Bone Squamous Cell Carcinoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050896

Summaries for Bone Squamous Cell Carcinoma

Disease Ontology : 12 A bone carcinoma that derives from squamous epithelial cells.

MalaCards based summary : Bone Squamous Cell Carcinoma is related to squamous cell carcinoma and bone cancer. An important gene associated with Bone Squamous Cell Carcinoma is STAT3 (Signal Transducer And Activator Of Transcription 3), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. Affiliated tissues include bone, breast and lung, and related phenotypes are Increased cell migration and Reduced mammosphere formation

Related Diseases for Bone Squamous Cell Carcinoma

Diseases related to Bone Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 236)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 28.5 TP53 STAT3 NOTCH1 MMP9 EGFR CTTN
2 bone cancer 26.4 TP53 SERPINB5 RLN2 RECK NOTCH1 MMP9
3 breast implant-associated anaplastic large cell lymphoma 10.5 TP53 STAT3
4 ovarian seromucinous carcinoma 10.4 TP53 CDKN2A
5 adult teratoma 10.4 TP53 ENG
6 spitz nevus 10.4 TP53 CDKN2A
7 splenic diffuse red pulp small b-cell lymphoma 10.4 TP53 NOTCH1
8 malignant peritoneal mesothelioma 10.3 EGFR CDKN2A
9 esophageal leukoplakia 10.3 TP53 CCND1
10 vaginal tubulovillous adenoma 10.3 CTNNB1 CDKN2A
11 vaginal adenoma 10.3 CTNNB1 CDKN2A
12 esophageal basaloid squamous cell carcinoma 10.3 TP53 EGFR
13 alk-positive anaplastic large cell lymphoma 10.3 STAT3 JAK3
14 bowenoid papulosis 10.3 CDKN2A CCND1
15 pancreatic foamy gland adenocarcinoma 10.3 TP53 CCND1
16 middle ear squamous cell carcinoma 10.3 RECK MMP9
17 central nervous system lymphoma 10.3 TP53 STAT3 CDKN2A
18 auditory system cancer 10.2 RECK MMP9
19 frontal lobe neoplasm 10.2 TP53 EGFR
20 liver benign neoplasm 10.2 TP53 STAT3 CTNNB1
21 angiokeratoma of mibelli 10.2 MMP9 KDR
22 gallbladder adenoma 10.2 CTNNB1 CDKN2A
23 microcystic stromal tumor 10.2 CTNNB1 CCND1
24 adult liposarcoma 10.2 NOTCH1 CTNNB1
25 vulvar intraepithelial neoplasia 10.2 TP53 CTNNB1 CDKN2A
26 plasmablastic lymphoma 10.2 NOTCH1 CDKN2A
27 vascular cancer 10.2 TP53 KDR ENG
28 cervix carcinoma 10.2 TP53 STAT3 CDKN2A
29 keratoacanthoma 10.2 TP53 STAT3 EGFR
30 tonsil squamous cell carcinoma 10.2 CDKN2A CCND1
31 intratubular embryonal carcinoma 10.2 TP53 MMP9
32 suppressor of tumorigenicity 3 10.2 TP53 CDKN2A
33 keratinizing squamous cell carcinoma 10.2 TP53 EGFR CDKN2A
34 vulvar disease 10.1 TP53 EGFR CDKN2A
35 soft tissue sarcoma 10.1 TP53 EGFR
36 peritoneum cancer 10.1 TP53 EGFR CDKN2A
37 anus cancer 10.1 TP53 EGFR CDKN2A
38 supratentorial cancer 10.1 TP53 EGFR CDKN2A
39 hypopharynx cancer 10.1 TP53 EGFR CDKN2A
40 papillary squamous carcinoma 10.1 EGFR CDKN2A
41 gliomatosis cerebri 10.1 TP53 EGFR CDKN2A
42 basaloid squamous cell carcinoma 10.1 TP53 EGFR CDKN2A
43 fibrillary astrocytoma 10.1 TP53 EGFR CDKN2A
44 anus disease 10.1 TP53 EGFR CDKN2A
45 pleural cancer 10.1 TP53 EGFR CDKN2A
46 nodular malignant melanoma 10.1 TP53 CDKN2A CCND1
47 ureteral obstruction 10.1 TP53 ENG CTNNB1
48 polymorphous low-grade adenocarcinoma 10.1 SERPINB5 CTNNB1 CCND1
49 merkel cell carcinoma 10.1 TP53 KDR CDKN2A
50 breast malignant phyllodes tumor 10.1 TP53 EGFR

Graphical network of the top 20 diseases related to Bone Squamous Cell Carcinoma:



Diseases related to Bone Squamous Cell Carcinoma

Symptoms & Phenotypes for Bone Squamous Cell Carcinoma

GenomeRNAi Phenotypes related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased cell migration GR00055-A-3 9.26 CTNNB1 EGFR KDR TYK2
2 Reduced mammosphere formation GR00396-S 9.17 CCND1 EGFR JAK3 KDR NOTCH1 RECK

MGI Mouse Phenotypes related to Bone Squamous Cell Carcinoma:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.43 CCND1 CDKN2A CTNNB1 CTTN EGFR JAK3
2 cardiovascular system MP:0005385 10.4 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
3 growth/size/body region MP:0005378 10.39 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
4 hematopoietic system MP:0005397 10.38 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
5 mortality/aging MP:0010768 10.35 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
6 embryo MP:0005380 10.3 CDKN2A CTNNB1 CTTN EGFR ENG KDR
7 immune system MP:0005387 10.3 CCND1 CDKN2A CTNNB1 CTTN EGFR JAK3
8 digestive/alimentary MP:0005381 10.27 CCND1 CDKN2A CTNNB1 EGFR ENG JAK3
9 integument MP:0010771 10.25 CCND1 CDKN2A CTNNB1 EGFR ENG KDR
10 craniofacial MP:0005382 10.18 CCND1 CTNNB1 EGFR ENG KDR NOTCH1
11 nervous system MP:0003631 10.18 CCND1 CDKN2A CTNNB1 EGFR ENG KDR
12 muscle MP:0005369 10.11 CDKN2A CTNNB1 EGFR ENG KDR MMP9
13 liver/biliary system MP:0005370 10.1 CDKN2A CTNNB1 EGFR KDR NOTCH1 RECK
14 neoplasm MP:0002006 10.03 CCND1 CDKN2A CTNNB1 EGFR MMP9 NOTCH1
15 normal MP:0002873 9.97 CCND1 CTNNB1 EGFR ENG KDR NOTCH1
16 no phenotypic analysis MP:0003012 9.91 CDKN2A CTNNB1 CTTN EGFR KDR SERPINB5
17 respiratory system MP:0005388 9.9 CCND1 CDKN2A CTNNB1 CTTN EGFR ENG
18 pigmentation MP:0001186 9.73 CDKN2A CTNNB1 EGFR JAK3 NOTCH1 TP53
19 skeleton MP:0005390 9.7 CCND1 CDKN2A CTNNB1 EGFR KDR MMP9
20 vision/eye MP:0005391 9.32 CCND1 CDKN2A CTNNB1 EGFR JAK3 KDR

Drugs & Therapeutics for Bone Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Bone Squamous Cell Carcinoma

Genetic Tests for Bone Squamous Cell Carcinoma

Anatomical Context for Bone Squamous Cell Carcinoma

MalaCards organs/tissues related to Bone Squamous Cell Carcinoma:

40
Bone, Breast, Lung, T Cells, Brain, Skin, Tongue

Publications for Bone Squamous Cell Carcinoma

Articles related to Bone Squamous Cell Carcinoma:

(show all 23)
# Title Authors PMID Year
1
Squamous cell carcinoma of the temporal bone: A current review. 61
31890889 2019
2
Dramatic response of CTNNB1 and VEGFR-2 mutant temporal bone squamous cell carcinoma to bevacizumab in combination with pemetrexed. 61
28915721 2017
3
Survival impact of local extension sites in surgically treated patients with temporal bone squamous cell carcinoma. 61
28044211 2017
4
Cortactin and phosphorylated cortactin tyr466 expression in temporal bone carcinoma. 61
28131549 2017
5
Expression of p53, p16, cyclin D1, epidermal growth factor receptor and Notch1 in patients with temporal bone squamous cell carcinoma. 61
27488595 2017
6
Temporal bone carcinoma: a first glance beyond the conventional clinical and pathological prognostic factors. 61
26518208 2016
7
Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence. 61
27330424 2016
8
Clinical and pathological parameters prognostic for increased risk of recurrence after postoperative radiotherapy for temporal bone carcinoma. 61
26348213 2016
9
A critical look at persistent problems in the diagnosis, staging and treatment of temporal bone carcinoma. 61
26549119 2015
10
Temporal bone squamous cell carcinoma - Penang experience. 61
26988214 2015
11
Relaxin-2 expression in temporal bone carcinoma. 61
25388992 2015
12
Recurrent squamous cell carcinoma of the temporal bone: critical analysis of cases with a poor prognosis. 61
25595048 2015
13
Survival outcomes of patients with temporal bone squamous cell carcinoma with different invasion patterns. 61
24347537 2015
14
Temporal bone squamous cell carcinoma: analyzing prognosis with univariate and multivariate models. 61
24108656 2014
15
Evaluation of the prognostic role of pSTAT3 expression in temporal bone squamous cell carcinoma. 61
24005169 2013
16
[The clinical analysis and treatment of facial paralysis caused by temporal bone tumors]. 61
24260866 2013
17
Expression of the tumour-suppressor maspin in temporal bone carcinoma. 61
23730906 2013
18
Neoangiogenesis in temporal bone carcinoma: the prognostic role of CD105. 61
22643443 2012
19
The problem of nodal disease in squamous cell carcinoma of the temporal bone. 61
20524790 2010
20
Treatment and outcome of advanced external auditory canal and middle ear squamous cell carcinoma. 61
19381105 2009
21
Squamous cell carcinoma of the temporal bone: results and management. 61
18520589 2008
22
A case of skull base mucormycosis with osteomyelitis secondary to temporal bone squamous cell carcinoma. 61
17240707 2006
23
Metastatic squamous cell carcinoma of the conjunctiva. 61
3173999 1988

Variations for Bone Squamous Cell Carcinoma

Expression for Bone Squamous Cell Carcinoma

Search GEO for disease gene expression data for Bone Squamous Cell Carcinoma.

Pathways for Bone Squamous Cell Carcinoma

Pathways related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.18 TYK2 TP53 STAT3 RLN2 NOTCH1 MMP9
2
Show member pathways
13.82 TP53 STAT3 NOTCH1 KDR JAK3 EGFR
3
Show member pathways
13.69 TP53 STAT3 NOTCH1 MMP9 KDR JAK3
4
Show member pathways
13.36 TYK2 TP53 STAT3 MMP9 JAK3 EGFR
5
Show member pathways
13.07 TYK2 TP53 STAT3 MMP9 JAK3 EGFR
6
Show member pathways
12.91 TYK2 TP53 STAT3 EGFR CTNNB1 CDKN2A
7
Show member pathways
12.89 TYK2 TP53 NOTCH1 KDR JAK3 EGFR
8
Show member pathways
12.88 STAT3 KDR EGFR CTNNB1 CCND1
9
Show member pathways
12.84 TP53 STAT3 MMP9 EGFR CTNNB1 CDKN2A
10
Show member pathways
12.81 TYK2 TP53 STAT3 JAK3 CCND1
11
Show member pathways
12.74 TP53 NOTCH1 EGFR CTNNB1 CDKN2A CCND1
12
Show member pathways
12.63 TP53 STAT3 KDR EGFR CCND1
13
Show member pathways
12.59 TYK2 TP53 STAT3 EGFR CTNNB1
14 12.53 TP53 STAT3 NOTCH1 MMP9 JAK3 EGFR
15
Show member pathways
12.52 TP53 STAT3 NOTCH1 MMP9 JAK3 EGFR
16
Show member pathways
12.51 TP53 STAT3 EGFR CTNNB1
17
Show member pathways
12.44 TP53 KDR EGFR CTNNB1
18
Show member pathways
12.4 STAT3 KDR JAK3 CTNNB1
19
Show member pathways
12.39 TYK2 TP53 STAT3 JAK3 CCND1
20
Show member pathways
12.38 TP53 SERPINB5 CDKN2A CCND1
21 12.34 TP53 JAK3 CDKN2A CCND1
22
Show member pathways
12.32 TYK2 STAT3 JAK3 EGFR CCND1
23 12.28 TP53 STAT3 JAK3 CDKN2A CCND1
24
Show member pathways
12.22 TYK2 TP53 STAT3 JAK3
25
Show member pathways
12.21 TP53 KDR EGFR CCND1
26 12.16 TP53 EGFR CTNNB1 CCND1
27
Show member pathways
12.12 STAT3 EGFR CTNNB1 CCND1
28 12.1 TP53 STAT3 MMP9 EGFR CTNNB1 CCND1
29 12.09 TP53 MMP9 KDR CTNNB1
30 12.01 TP53 MMP9 EGFR CCND1
31 12 TP53 NOTCH1 CTNNB1 CCND1
32 11.97 TP53 CTNNB1 CDKN2A CCND1
33 11.92 TP53 EGFR CTNNB1 CDKN2A CCND1
34 11.91 TYK2 STAT3 JAK3 EGFR
35 11.9 TYK2 TP53 STAT3 MMP9 JAK3 CCND1
36 11.87 TP53 STAT3 MMP9 KDR EGFR CTTN
37 11.85 STAT3 EGFR CTNNB1 CCND1
38 11.79 MMP9 CTNNB1 CCND1
39 11.77 TP53 STAT3 SERPINB5 RECK NOTCH1 MMP9
40 11.72 TP53 KDR CTNNB1 CDKN2A
41 11.69 STAT3 MMP9 EGFR
42 11.69 TP53 MMP9 EGFR CDKN2A CCND1
43 11.68 SERPINB5 RECK NOTCH1 MMP9 KDR ENG
44 11.63 STAT3 ENG CTNNB1
45
Show member pathways
11.61 STAT3 MMP9 EGFR CCND1
46 11.56 TYK2 STAT3 EGFR
47 11.54 STAT3 NOTCH1 KDR
48 11.53 TP53 EGFR CDKN2A CCND1
49 11.52 NOTCH1 CTNNB1 CCND1
50
Show member pathways
11.52 STAT3 JAK3 CCND1

GO Terms for Bone Squamous Cell Carcinoma

Cellular components related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Wnt signalosome GO:1990909 8.96 RECK CTNNB1
2 receptor complex GO:0043235 8.92 NOTCH1 KDR ENG EGFR

Biological processes related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 50)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 10.14 TP53 STAT3 NOTCH1 ENG EGFR CTNNB1
2 phosphorylation GO:0016310 10.07 TYK2 STAT3 KDR JAK3 EGFR CDKN2A
3 negative regulation of cell proliferation GO:0008285 10.03 TP53 STAT3 NOTCH1 CTNNB1 CDKN2A
4 positive regulation of transcription, DNA-templated GO:0045893 10.02 TP53 STAT3 NOTCH1 EGFR CTNNB1 CDKN2A
5 heart development GO:0007507 9.98 TP53 NOTCH1 ENG CTNNB1
6 positive regulation of apoptotic process GO:0043065 9.98 TP53 NOTCH1 MMP9 CTNNB1 CDKN2A
7 extracellular matrix organization GO:0030198 9.97 SERPINB5 RECK MMP9 KDR
8 cell proliferation GO:0008283 9.96 TP53 STAT3 EGFR CTNNB1
9 negative regulation of apoptotic process GO:0043066 9.95 TP53 STAT3 MMP9 KDR EGFR CTNNB1
10 positive regulation of cell proliferation GO:0008284 9.93 STAT3 NOTCH1 KDR EGFR CTNNB1 CCND1
11 response to drug GO:0042493 9.89 TP53 STAT3 ENG CTNNB1 CCND1
12 lung development GO:0030324 9.88 NOTCH1 EGFR CTNNB1
13 positive regulation of angiogenesis GO:0045766 9.88 STAT3 RLN2 KDR ENG
14 liver development GO:0001889 9.86 NOTCH1 EGFR CCND1
15 peptidyl-tyrosine phosphorylation GO:0018108 9.83 TYK2 KDR JAK3 EGFR
16 negative regulation of gene expression GO:0010629 9.83 TP53 NOTCH1 KDR ENG CTNNB1
17 positive regulation of epithelial cell proliferation GO:0050679 9.81 NOTCH1 EGFR CCND1
18 vasculogenesis GO:0001570 9.81 KDR ENG CTNNB1
19 positive regulation of cell migration GO:0030335 9.77 STAT3 NOTCH1 MMP9 KDR EGFR
20 regulation of cell proliferation GO:0042127 9.72 TP53 STAT3 NOTCH1 EGFR CTNNB1
21 cardiac septum morphogenesis GO:0060411 9.71 TP53 NOTCH1
22 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.71 STAT3 JAK3
23 cellular response to reactive oxygen species GO:0034614 9.71 TP53 MMP9 EGFR
24 response to estradiol GO:0032355 9.71 STAT3 EGFR CTNNB1 CCND1
25 replicative senescence GO:0090399 9.7 TP53 CDKN2A
26 negative regulation of oligodendrocyte differentiation GO:0048715 9.7 NOTCH1 CTNNB1
27 interleukin-15-mediated signaling pathway GO:0035723 9.7 STAT3 JAK3
28 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.69 NOTCH1 ENG
29 interleukin-27-mediated signaling pathway GO:0070106 9.69 TYK2 STAT3
30 regulation of mitochondrial membrane permeability GO:0046902 9.69 TP53 STAT3
31 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.68 TP53 EGFR
32 somatic stem cell division GO:0048103 9.68 NOTCH1 CDKN2A
33 response to leptin GO:0044321 9.67 STAT3 CCND1
34 cardiac ventricle morphogenesis GO:0003208 9.67 NOTCH1 ENG
35 interleukin-23-mediated signaling pathway GO:0038155 9.66 TYK2 STAT3
36 interleukin-9-mediated signaling pathway GO:0038113 9.66 STAT3 JAK3
37 astrocyte differentiation GO:0048708 9.65 STAT3 NOTCH1
38 interleukin-21-mediated signaling pathway GO:0038114 9.65 STAT3 JAK3
39 positive regulation of protein phosphorylation GO:0001934 9.65 MMP9 KDR ENG EGFR CCND1
40 mitotic G1 DNA damage checkpoint GO:0031571 9.64 TP53 CCND1
41 cytokine-mediated signaling pathway GO:0019221 9.63 TYK2 TP53 STAT3 MMP9 JAK3 CCND1
42 venous blood vessel morphogenesis GO:0048845 9.62 NOTCH1 ENG
43 response to corticosteroid GO:0031960 9.62 NOTCH1 ENG
44 cardiac atrium morphogenesis GO:0003209 9.61 NOTCH1 ENG
45 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.61 TP53 NOTCH1
46 central nervous system vasculogenesis GO:0022009 9.57 ENG CTNNB1
47 cell migration involved in endocardial cushion formation GO:0003273 9.56 NOTCH1 ENG
48 response to UV-A GO:0070141 9.51 EGFR CCND1
49 positive regulation of gene expression GO:0010628 9.5 TP53 STAT3 RLN2 NOTCH1 ENG CTNNB1
50 sprouting angiogenesis GO:0002040 8.92 RECK NOTCH1 KDR ENG

Molecular functions related to Bone Squamous Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.88 TYK2 KDR JAK3 EGFR CDKN2A CCND1
2 protein kinase activity GO:0004672 9.83 TYK2 KDR JAK3 EGFR CCND1
3 transcription factor binding GO:0008134 9.77 TP53 STAT3 CTNNB1 CDKN2A CCND1
4 protein kinase binding GO:0019901 9.63 TP53 STAT3 EGFR CTNNB1 CDKN2A CCND1
5 protein tyrosine kinase activity GO:0004713 9.56 TYK2 KDR JAK3 EGFR
6 disordered domain specific binding GO:0097718 9.5 TP53 CTNNB1 CDKN2A
7 enzyme binding GO:0019899 9.43 TP53 NOTCH1 EGFR CYP2C19 CTNNB1 CCND1
8 protein phosphatase binding GO:0019903 9.02 TP53 STAT3 JAK3 EGFR CTNNB1

Sources for Bone Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....