Borderline Glaucoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Borderline Glaucoma

MalaCards integrated aliases for Borderline Glaucoma:

Name: Borderline Glaucoma ¹² ¹⁵ ⁷¹

Preglaucoma ¹² ⁷¹

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:9283

ICD9CM ³⁴ 365.00

SNOMED-CT ⁶⁷ 359633007

ICD10 ³² H40.00

UMLS ⁷¹ C0549470 C1533674

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Summaries for Borderline Glaucoma

Disease Ontology : ¹² A glaucoma characterized by clinical features and risk factors that are associated with high likelihood to developing optic atrophy secondary to glaucoma in the future. These features may include elevated intraocular pressure, retinal nerve fiber layer abnormalities, abnormal anterior chamber angles, and/or a positive family history for glaucoma without any evidence of current optic nerve atrophy.

MalaCards based summary : Borderline Glaucoma, also known as preglaucoma, is related to anatomical narrow angle borderline glaucoma and steroid-induced glaucoma - borderline. An important gene associated with Borderline Glaucoma is GSTM5 (Glutathione S-Transferase Mu 5), and among its related pathways/superpathways are JAK-STAT signaling pathway and Arginine and proline metabolism. Affiliated tissues include eye, and related phenotype is Decreased shRNA abundance.

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Related Diseases for Borderline Glaucoma

Diseases related to Borderline Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)

#	Related Disease	Score	Top Affiliating Genes
1	anatomical narrow angle borderline glaucoma	11.5
2	steroid-induced glaucoma - borderline	11.3
3	intraocular pressure quantitative trait locus	10.3
4	ocular hypertension	10.3
5	open-angle glaucoma	10.1
6	spastic paraplegia 9b, autosomal recessive	9.9	PYCR3 PYCR1
7	autosomal recessive cutis laxa type iii	9.9	PYCR3 PYCR1
8	spastic paraplegia 9a, autosomal dominant	9.9	PYCR3 PYCR1
9	cutis laxa, autosomal recessive, type iib	9.9	PYCR3 PYCR1
10	leukodystrophy, hypomyelinating, 10	9.8	PYCR3 PYCR1
11	hyperprolinemia	9.7	PYCR3 PYCR1

Comorbidity relations with Borderline Glaucoma via Phenotypic Disease Network (PDN):

Hypertension, Essential

Graphical network of the top 20 diseases related to Borderline Glaucoma:

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Symptoms & Phenotypes for Borderline Glaucoma

GenomeRNAi Phenotypes related to Borderline Glaucoma according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance	GR00297-A	8.8	GSTM5 PYCR1 PYCR3

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Drugs & Therapeutics for Borderline Glaucoma

Search Clinical Trials , NIH Clinical Center for Borderline Glaucoma

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Genetic Tests for Borderline Glaucoma

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Anatomical Context for Borderline Glaucoma

MalaCards organs/tissues related to Borderline Glaucoma:

⁴⁰

Eye

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Publications for Borderline Glaucoma

Articles related to Borderline Glaucoma:

(show all 28)

#	Title	Authors	PMID	Year
1	Update: Incidence of Glaucoma Diagnoses, Active Component, U.S. Armed Forces, 2013-2017. ⁶¹	Clark L...Stahlman S	30807198	2019
2	Effect of systemic antihypertensives on change in intraocular pressure after initiating topical prostaglandins for primary open-angle glaucoma. ⁶¹	Siddiqui M...Singer M	30774300	2019
3	Graft Survival after Penetrating Keratoplasty in Cases of Trabeculectomy versus Ahmed Valve Implant. ⁶¹	Elhofi A...Helaly HA	30186628	2018
4	Glaucoma, active component, U.S. Armed Forces, 1998-2013. ⁶¹	Hurt L	25555211	2014
5	Predisease: when does it make sense? ⁶¹	Viera AJ	21624963	2011
6	The role of clinical parapapillary atrophy evaluation in the diagnosis of open angle glaucoma. ⁶¹	Ehrlich JR...Radcliffe NM	20856591	2010
7	Categorizing the stage of glaucoma from pre-diagnosis to end-stage disease. ⁶¹	Mills RP...Doyle JJ	16386972	2006
8	Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for macular edema from central retinal vein occlusion. ⁶¹	Rosenfeld PJ...Puliafito CA	16156153	2005
9	Inhaled and nasal glucocorticoids and the risks of ocular hypertension or open-angle glaucoma. ⁶¹	Garbe E...Suissa S	9042844	1997
10	Automated static perimetry in myopes with peripapillary crescents--Part II. ⁶¹	Rudnicka AR...Edgar DF	8944186	1996
11	Early changes in optic disc compliance and surface position in experimental glaucoma. ⁶¹	Burgoyne CF...Varma R	9098280	1995
12	[Surgical results of dissection of the superficial temporal artery in patients with preglaucoma and initial open-angle glaucoma]. ⁶¹	Shilkin GA...Mikhailova GD	2755669	1989
13	[Various approaches to the diagnosis of initial open-angle glaucoma]. ⁶¹	Volkov VV	2666894	1989
14	[The importance of a new compression test in the diagnosis of preglaucoma and initial glaucoma]. ⁶¹	Vodovozov AM...Balalin SV	2755665	1989
15	[Ocular hypertension, suspected glaucoma, preglaucoma or glaucoma? The points of view of scientists]. ⁶¹	Volkov VV	3071889	1988
16	Ocular hypertension, glaucoma suspect, preglaucoma, or glaucoma? Synopsis of views. ⁶¹	Johnson TD...Zimmerman TJ	3504114	1986
17	In response to Johnson and Zimmerman. Re: A revisit: ocular hypertension, glaucoma suspect, preglaucoma, or glaucoma? ⁶¹	Phelps CD	4073711	1985
18	A revisit: ocular hypertension, glaucoma suspect, preglaucoma, or glaucoma? ⁶¹	Shields MB	4051376	1985
19	A revisit: ocular hypertension, glaucoma suspect, preglaucoma, or glaucoma? ⁶¹	Johnson TD...Zimmerman TJ	4037597	1985
20	[Eye hemodynamic function in patients with preglaucoma and initial open-angle glaucoma]. ⁶¹	Shilkin GA...Anisimov SI	6659250	1983
21	Combined cataract extraction and glaucoma surgery. ⁶¹	Shields MB	7088507	1982
22	[Diagnostic and differential diagnostic significance of early changes in the field of vision and ocular hydrodynamics in preglaucoma]. ⁶¹	Astapova NN	7335279	1981
23	Catecholamine content of the lacrimal fluid of healthy people and glaucoma patients. ⁶¹	Zubareva TV...Kiseleva ZM	593659	1977
24	[Results of a 3-year follow-up control of preglaucoma]. ⁶¹	Schill J...Wiechmann I	4647521	1972
25	Evaluation of recent provocative tests for preglaucoma. ⁶¹	WEINSTEIN P	14771225	1950
26	Preglaucoma. ⁶¹	STROUD SK	18905578	1948
27	Double triggered retinal pulse, sign of preglaucoma? its documentation by cineretinography. ⁶¹	LIJO PAVIA J	20999304	1946
28	Preglaucoma. ⁶¹	GRADLE HS	21027000	1946

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Genes for Borderline Glaucoma

Genes related to Borderline Glaucoma (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	GSTM5	Glutathione S-Transferase Mu 5	Protein Coding	6.1	DISEASES inferred ¹⁵
2	PYCR1	Pyrroline-5-Carboxylate Reductase 1	Protein Coding	5.66	DISEASES inferred ¹⁵
3	PIAS1	Protein Inhibitor Of Activated STAT 1	Protein Coding	5.48	DISEASES inferred ¹⁵
4	PYCR3	Pyrroline-5-Carboxylate Reductase 3	Protein Coding	5.46	DISEASES inferred ¹⁵
5	SOCS4	Suppressor Of Cytokine Signaling 4	Protein Coding	5.35	DISEASES inferred ¹⁵
6	SOCS6	Suppressor Of Cytokine Signaling 6	Protein Coding	5.31	DISEASES inferred ¹⁵
7	GPNMB	Glycoprotein Nmb	Protein Coding	5.29	DISEASES inferred ¹⁵

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Variations for Borderline Glaucoma

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Expression for Borderline Glaucoma

Search GEO for disease gene expression data for Borderline Glaucoma.

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Pathways for Borderline Glaucoma

Pathways related to Borderline Glaucoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	JAK-STAT signaling pathway ³⁶ Show member pathways B-Cell Development ⁶³ IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types ⁶⁴ Interleukin-19, 20, 22, 24 ⁶⁵ Jak/STAT Signaling Pathway ⁶⁴ Type III interferon signaling ¹	11.73	SOCS6 SOCS4 PIAS1
2	Arginine and proline metabolism ³⁶ Show member pathways 4-hydroxyproline degradation ¹ Agmatine biosynthesis ⁶⁵ putrescine biosynthesis II ¹	11.09	PYCR3 PYCR1
3	Amino acid synthesis and interconversion (transamination) ⁶⁵ Show member pathways asparagine biosynthesis ¹ L-cysteine degradation II ¹ Serine biosynthesis ⁶⁵	10.88	PYCR3 PYCR1
4	IL10 Signaling Pathway ⁶⁶	10.42	SOCS6 SOCS4
5	Urea cycle and metabolism of amino groups ¹ Show member pathways proline biosynthesis ¹ putrescine biosynthesis I ¹ spermine biosynthesis ¹	10	PYCR3 PYCR1

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GO Terms for Borderline Glaucoma

Cellular components related to Borderline Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intercellular bridge	GO:0045171	8.96	PYCR3 GSTM5
2	phosphatidylinositol 3-kinase complex	GO:0005942	8.62	SOCS6 SOCS4

Biological processes related to Borderline Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of growth	GO:0040008	9.48	SOCS6 SOCS4
2	positive regulation of proteasomal ubiquitin-dependent protein catabolic process	GO:0032436	9.46	SOCS4 PIAS1
3	negative regulation of signal transduction	GO:0009968	9.43	SOCS6 SOCS4
4	phosphatidylinositol phosphorylation	GO:0046854	9.4	SOCS6 SOCS4
5	cellular amino acid biosynthetic process	GO:0008652	9.37	PYCR3 PYCR1
6	JAK-STAT cascade	GO:0007259	9.32	SOCS6 PIAS1
7	regulation of phosphatidylinositol 3-kinase activity	GO:0043551	9.26	SOCS6 SOCS4
8	negative regulation of T cell activation	GO:0050868	9.16	SOCS6 GPNMB
9	L-proline biosynthetic process	GO:0055129	8.96	PYCR3 PYCR1
10	proline biosynthetic process	GO:0006561	8.62	PYCR3 PYCR1

Molecular functions related to Borderline Glaucoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	1-phosphatidylinositol-3-kinase regulator activity	GO:0046935	8.96	SOCS6 SOCS4
2	pyrroline-5-carboxylate reductase activity	GO:0004735	8.62	PYCR3 PYCR1

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Sources for Borderline Glaucoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia