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MCID: BRD008
MIFTS: 26

Borderline Glaucoma

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Borderline Glaucoma

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MalaCards integrated aliases for Borderline Glaucoma:

Name: Borderline Glaucoma 12 15 71
Preglaucoma 12 71

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9283
ICD9CM 34 365.00
ICD10 32 H40.00
UMLS 71 C0549470 C1533674
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Summaries for Borderline Glaucoma

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Disease Ontology : 12 A glaucoma characterized by clinical features and risk factors that are associated with high likelihood to developing optic atrophy secondary to glaucoma in the future. These features may include elevated intraocular pressure, retinal nerve fiber layer abnormalities, abnormal anterior chamber angles, and/or a positive family history for glaucoma without any evidence of current optic nerve atrophy.

MalaCards based summary : Borderline Glaucoma, also known as preglaucoma, is related to anatomical narrow angle borderline glaucoma and steroid-induced glaucoma - borderline. An important gene associated with Borderline Glaucoma is GSTM5 (Glutathione S-Transferase Mu 5), and among its related pathways/superpathways are JAK-STAT signaling pathway and Carbon metabolism. Affiliated tissues include testes and eye, and related phenotype is Decreased shRNA abundance.

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Related Diseases for Borderline Glaucoma

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Diseases related to Borderline Glaucoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 anatomical narrow angle borderline glaucoma 12.7
2 steroid-induced glaucoma - borderline 11.6
3 intraocular pressure quantitative trait locus 10.6
4 ocular hypertension 10.6
5 open-angle glaucoma 10.4
6 spastic paraplegia 9b, autosomal recessive 10.0 PYCR3 PYCR1
7 spastic paraplegia 9a, autosomal dominant 10.0 PYCR3 PYCR1
8 cutis laxa 9.8 PYCR1 GORAB
9 autosomal recessive cutis laxa type i 9.8 PYCR1 GORAB
10 cutis laxa, autosomal recessive, type iiib 9.7 PYCR1 GORAB
11 cutis laxa, autosomal recessive, type ib 9.7 PYCR1 GORAB
12 cutis laxa, autosomal recessive, type iia 9.7 PYCR1 GORAB
13 leukodystrophy, hypomyelinating, 10 9.7 PYCR3 PYCR2 PYCR1
14 cutis laxa, autosomal recessive, type iiia 9.7 PYCR1 GORAB
15 hyperprolinemia 9.7 PYCR3 PYCR1
16 cutis laxa, autosomal recessive, type ic 9.6 PYCR1 GORAB
17 cutis laxa, autosomal recessive, type ia 9.6 PYCR1 GORAB
18 geroderma osteodysplasticum 9.5 PYCR1 GORAB
19 autosomal recessive cutis laxa type iii 9.4 PYCR2 PYCR1 GORAB
20 autosomal recessive cutis laxa type ii classic type 9.3 PYCR2 PYCR1 GORAB
21 cutis laxa, autosomal recessive, type iib 9.1 PYCR3 PYCR2 PYCR1 GORAB

Comorbidity relations with Borderline Glaucoma via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Borderline Glaucoma:



Diseases related to Borderline Glaucoma
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Symptoms & Phenotypes for Borderline Glaucoma

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GenomeRNAi Phenotypes related to Borderline Glaucoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00297-A 8.8 GSTM5 PYCR1 PYCR3
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Drugs & Therapeutics for Borderline Glaucoma

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Search Clinical Trials , NIH Clinical Center for Borderline Glaucoma

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Genetic Tests for Borderline Glaucoma

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Anatomical Context for Borderline Glaucoma

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MalaCards organs/tissues related to Borderline Glaucoma:

40
Testes, Eye
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Publications for Borderline Glaucoma

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Articles related to Borderline Glaucoma:

(show all 27)
# Title Authors PMID Year
1
Update: Incidence of Glaucoma Diagnoses, Active Component, U.S. Armed Forces, 2013-2017. 61
30807198 2019
2
Effect of systemic antihypertensives on change in intraocular pressure after initiating topical prostaglandins for primary open-angle glaucoma. 61
30774300 2019
3
Graft Survival after Penetrating Keratoplasty in Cases of Trabeculectomy versus Ahmed Valve Implant. 61
30186628 2018
4
Glaucoma, active component, U.S. Armed Forces, 1998-2013. 61
25555211 2014
5
Predisease: when does it make sense? 61
21624963 2011
6
The role of clinical parapapillary atrophy evaluation in the diagnosis of open angle glaucoma. 61
20856591 2010
7
Categorizing the stage of glaucoma from pre-diagnosis to end-stage disease. 61
16386972 2006
8
Optical coherence tomography findings after an intravitreal injection of bevacizumab (avastin) for macular edema from central retinal vein occlusion. 61
16156153 2005
9
Inhaled and nasal glucocorticoids and the risks of ocular hypertension or open-angle glaucoma. 61
9042844 1997
10
Automated static perimetry in myopes with peripapillary crescents--Part II. 61
8944186 1996
11
Early changes in optic disc compliance and surface position in experimental glaucoma. 61
9098280 1995
12
[Surgical results of dissection of the superficial temporal artery in patients with preglaucoma and initial open-angle glaucoma]. 61
2755669 1989
13
[The importance of a new compression test in the diagnosis of preglaucoma and initial glaucoma]. 61
2755665 1989
14
[Various approaches to the diagnosis of initial open-angle glaucoma]. 61
2666894 1989
15
[Ocular hypertension, suspected glaucoma, preglaucoma or glaucoma? The points of view of scientists]. 61
3071889 1988
16
Ocular hypertension, glaucoma suspect, preglaucoma, or glaucoma? Synopsis of views. 61
3504114 1986
17
In response to Johnson and Zimmerman. Re: A revisit: ocular hypertension, glaucoma suspect, preglaucoma, or glaucoma? 61
4073711 1985
18
A revisit: ocular hypertension, glaucoma suspect, preglaucoma, or glaucoma? 61
4051376 1985
19
A revisit: ocular hypertension, glaucoma suspect, preglaucoma, or glaucoma? 61
4037597 1985
20
[Eye hemodynamic function in patients with preglaucoma and initial open-angle glaucoma]. 61
6659250 1983
21
Combined cataract extraction and glaucoma surgery. 61
7088507 1982
22
[Diagnostic and differential diagnostic significance of early changes in the field of vision and ocular hydrodynamics in preglaucoma]. 61
7335279 1981
23
Catecholamine content of the lacrimal fluid of healthy people and glaucoma patients. 61
593659 1977
24
[Results of a 3-year follow-up control of preglaucoma]. 61
4647521 1972
25
Evaluation of recent provocative tests for preglaucoma. 61
14771225 1950
26
Preglaucoma. 61
18905578 1948
27
Preglaucoma. 61
21027000 1946
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Variations for Borderline Glaucoma

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Expression for Borderline Glaucoma

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Search GEO for disease gene expression data for Borderline Glaucoma.
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Pathways for Borderline Glaucoma

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Pathways related to Borderline Glaucoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
JAK-STAT signaling pathway 36
Show member pathways
 11.94 SOCS6 SOCS4 PIAS1
2
Carbon metabolism 36
Show member pathways
 11.76 PYCR3 PYCR2 PYCR1
3
Arginine and proline metabolism 36
Show member pathways
 10.89 PYCR3 PYCR2 PYCR1
4
IL10 Signaling Pathway 66
10.78 SOCS6 SOCS4
5
Urea cycle and metabolism of amino groups 1
Show member pathways
 10.54 PYCR3 PYCR1
6
Amino acid synthesis and interconversion (transamination) 65
Show member pathways
 10.42 PYCR3 PYCR2 PYCR1
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GO Terms for Borderline Glaucoma

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Cellular components related to Borderline Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol 3-kinase complex GO:0005942 8.62 SOCS6 SOCS4

Biological processes related to Borderline Glaucoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 cellular response to oxidative stress GO:0034599 9.49 PYCR2 PYCR1
2 regulation of growth GO:0040008 9.48 SOCS6 SOCS4
3 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 9.46 SOCS4 PIAS1
4 negative regulation of signal transduction GO:0009968 9.43 SOCS6 SOCS4
5 phosphatidylinositol phosphorylation GO:0046854 9.4 SOCS6 SOCS4
6 JAK-STAT cascade GO:0007259 9.37 SOCS6 PIAS1
7 cellular amino acid biosynthetic process GO:0008652 9.33 PYCR3 PYCR2 PYCR1
8 regulation of phosphatidylinositol 3-kinase activity GO:0043551 9.32 SOCS6 SOCS4
9 negative regulation of T cell activation GO:0050868 9.26 SOCS6 GPNMB
10 L-proline biosynthetic process GO:0055129 9.13 PYCR3 PYCR2 PYCR1
11 proline biosynthetic process GO:0006561 8.8 PYCR3 PYCR2 PYCR1

Molecular functions related to Borderline Glaucoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.81 SOCS6 SOCS4 PYCR3 PYCR2 PYCR1 PIAS1
2 1-phosphatidylinositol-3-kinase regulator activity GO:0046935 8.96 SOCS6 SOCS4
3 pyrroline-5-carboxylate reductase activity GO:0004735 8.8 PYCR3 PYCR2 PYCR1
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Sources for Borderline Glaucoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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