MCID: BRD005
MIFTS: 30

Borderline Leprosy

Categories: Endocrine diseases, Eye diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Respiratory diseases

Aliases & Classifications for Borderline Leprosy

MalaCards integrated aliases for Borderline Leprosy:

Name: Borderline Leprosy 12 15 17 74
Midborderline Leprosy 12 74
Borderline or Dimorphous Leprosy 12
Leprosy, Borderline 45

Classifications:



External Ids:

Disease Ontology 12 DOID:1023
ICD9CM 36 030.3
MeSH 45 D015439
SNOMED-CT 69 50521002
ICD10 34 A30.3

Summaries for Borderline Leprosy

Disease Ontology : 12 A leprosy that results in small numerous red irregularly shaped plaques.

MalaCards based summary : Borderline Leprosy, also known as midborderline leprosy, is related to leprosy 3 and tuberculoid leprosy. An important gene associated with Borderline Leprosy is NOS2 (Nitric Oxide Synthase 2). Affiliated tissues include skin, eye and testes, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Borderline Leprosy

Diseases related to Borderline Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 leprosy 3 31.6 MLLT1 SDHD
2 tuberculoid leprosy 30.6 MLLT1 SDHD
3 hansen's disease 10.5
4 neuritis 10.0
5 indeterminate leprosy 10.0 DEFB1 MLLT1
6 retinal vasculitis 10.0 APOH NOS2
7 testicular disease 9.9 MLLT1 SDHD
8 upper respiratory tract disease 9.9 MLLT1 SDHD
9 arthritis 9.9
10 lymphoma 9.9
11 portal hypertension 9.9
12 lepromatous leprosy 9.9
13 guillain-barre syndrome 9.9
14 urticaria 9.9
15 lymphadenitis 9.9
16 cheilitis 9.9
17 pulmonary tuberculosis 9.9
18 granulocytopenia 9.9
19 granulomatous slack skin disease 9.9
20 gastritis 9.9 DEFB1 NOS2
21 peripheral nervous system disease 9.7 MLLT1 SDHD

Graphical network of the top 20 diseases related to Borderline Leprosy:



Diseases related to Borderline Leprosy

Symptoms & Phenotypes for Borderline Leprosy

GenomeRNAi Phenotypes related to Borderline Leprosy according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.4 MLLT1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.4 APOH MLLT1 SDHD
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.4 SDHD
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.4 APOH
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.4 SDHD
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.4 SDHD
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.4 APOH
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.4 MLLT1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.4 MLLT1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.4 MLLT1

Drugs & Therapeutics for Borderline Leprosy

Search Clinical Trials , NIH Clinical Center for Borderline Leprosy

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: leprosy, borderline

Genetic Tests for Borderline Leprosy

Anatomical Context for Borderline Leprosy

MalaCards organs/tissues related to Borderline Leprosy:

42
Skin, Eye, Testes, T Cells

Publications for Borderline Leprosy

Articles related to Borderline Leprosy:

(show top 50) (show all 84)
# Title Authors Year
1
Mid borderline leprosy in type Bα Blaschko linear pattern: a rare phenomenon. ( 30345504 )
2019
2
Mid-borderline leprosy masquerading as an overlap syndrome. ( 29718382 )
2018
3
A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction? ( 29262820 )
2017
4
Addition of Mycobacterium indicus pranii vaccine as an immunotherapeutic to standard chemotherapy in borderline leprosy: a double-blind study to assess clinical improvement (preliminary report). ( 27518926 )
2017
5
Multiple nerve abscesses: An unusual manifestation of lepra reaction in a patient with borderline leprosy. ( 27841214 )
2016
6
Evaluation of apoptosis in skin biopsies of patients of borderline leprosy and lepra type 1 reaction. ( 25657399 )
2015
7
Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil. ( 25605482 )
2015
8
Tuberculous lymphadenitis and borderline leprosy in a patient with isolated unconjugated hyperbilirubinaemia. ( 25385559 )
2014
9
Evaluation of key histologic variables in skin biopsies of patients of borderline leprosy with type 1 lepra reaction. ( 25201839 )
2014
10
Borderline leprosy masquerading as cheilitis granulomatosa: a case report. ( 23741887 )
2013
11
Mid-borderline leprosy. ( 23741685 )
2013
12
Clinical and histopathological evaluation of the effect of addition of immunotherapy with Mw vaccine to standard chemotherapy in borderline leprosy. ( 23720894 )
2012
13
Early diagnosis of relapse in borderline leprosy: two case reports. ( 22183459 )
2011
14
A case of borderline leprosy presenting with urticaria-like eruptions: are there lessons to be learned for allergists? ( 21988321 )
2011
15
Concomittant pulmonary tuberculosis and borderline leprosy with type-II lepra reaction in single patient. ( 20539766 )
2010
16
Granulomatous slack skin clinically and histologically masquerading as borderline leprosy in its early stages. ( 19171548 )
2009
17
Type I reaction in a borderline leprosy case successfully treated with multidrug therapy and ofloxacin. ( 18986365 )
2008
18
Leprosy serology (ML Flow test) in borderline leprosy patients classified as paucibacillary by counting cutaneous lesions: an useful tool. ( 19618075 )
2008
19
Chronic inflammatory joint disease revealing borderline leprosy. ( 16213770 )
2006
20
Guillain-Barré syndrome-like presentation in borderline leprosy with type-2 reaction. ( 16638414 )
2006
21
Pitfalls in the cytological classification of borderline leprosy in the Ridley-Jopling scale. ( 15176024 )
2004
22
Nitrotyrosine localization to dermal nerves in borderline leprosy. ( 15030344 )
2004
23
A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient. ( 12862258 )
2003
24
Reactions in borderline leprosy. ( 12708730 )
2002
25
Expression of inducible nitric oxide synthase and nitrotyrosine in borderline leprosy lesions. ( 11736907 )
2001
26
Sequential erythema nodosum leprosum and reversal reaction with similar lesional cytokine mRNA patterns in a borderline leprosy patient. ( 11167702 )
2001
27
beta2-Glycoprotein I-dependent anticardiolipin antibodies as risk factor for reactions in borderline leprosy patients. ( 9934366 )
1998
28
Contribution of type 1 reactions to sensory and motor function loss in borderline leprosy patients and the efficacy of treatment with prednisone. ( 9934360 )
1998
29
Serial Mitsuda tests for identification of reactional tuberculoid and reactional borderline leprosy forms. ( 9728451 )
1998
30
Reversal reaction in borderline leprosy is associated with a polarized shift to type 1-like Mycobacterium leprae T cell reactivity in lesional skin: a follow-up study. ( 9379047 )
1997
31
Immunotherapy of lepromin-negative borderline leprosy patients with low-dose Convit vaccine as an adjunct to multidrug therapy; a six-year follow-up study in Calcutta. ( 9207754 )
1997
32
Changes of autonomic nerve function in the first two weeks of acute neuritis in a patient with borderline leprosy. ( 8690978 )
1996
33
Case report: cutaneous lymphoma and borderline leprosy simulating lepromatous leprosy. ( 8684256 )
1996
34
Generalized rash in a Dominican immigrant. Borderline leprosy (Hansen's disease) with type 1 upgrading (ie, reversal) reaction. ( 8546490 )
1996
35
Phenotype and cytokine expression of intralesional cells in borderline leprosy. ( 7963910 )
1994
36
Pathogenesis of generalized nodular type I reaction in a borderline leprosy patient. ( 7714358 )
1994
37
Scrotal lesion in borderline leprosy. ( 8182293 )
1993
38
Risk factors for type-1 reactions in borderline leprosy patients. ( 1679473 )
1991
39
Additional markers for the type I reactional states of borderline leprosy. ( 2393071 )
1990
40
Scalp lesions in borderline leprosy. ( 2703742 )
1989
41
Late onset of a reversal reaction in borderline leprosy. ( 2654221 )
1989
42
A borderline leprosy lesion on the palate: a case report. ( 3398680 )
1988
43
Type 1 (reversal) lepra reaction in borderline leprosy with unusual clinical presentation--a case report. ( 3655433 )
1987
44
LDH profile in an unusual case of borderline leprosy in reaction associated with portal hypertension. ( 3440847 )
1987
45
An unusual bullous reaction in borderline leprosy. ( 3298904 )
1987
46
Unilateral oedema of reversal reaction (RR) in borderline leprosy. ( 3784765 )
1986
47
Multiple relapses in borderline leprosy--a case report. ( 3553362 )
1986
48
The outpatient treatment of nerve damage in patients with borderline leprosy using a semi-standardized steroid regimen. ( 4021699 )
1985
49
An electron microscopic study on macrophages and lymphocytes in lepromatous and borderline leprosy. ( 3889192 )
1985
50
Immuno-stimulatory effect of levamisole in borderline leprosy cases. ( 3839822 )
1985

Variations for Borderline Leprosy

Expression for Borderline Leprosy

Search GEO for disease gene expression data for Borderline Leprosy.

Pathways for Borderline Leprosy

GO Terms for Borderline Leprosy

Biological processes related to Borderline Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to bacterium GO:0009617 9.16 DEFB1 NOS2
2 defense response to Gram-negative bacterium GO:0050829 8.96 DEFB1 NOS2
3 innate immune response in mucosa GO:0002227 8.62 DEFB1 NOS2

Molecular functions related to Borderline Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.62 NOS2 SDHD

Sources for Borderline Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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