MCID: BRD005
MIFTS: 27

Borderline Leprosy

Categories: Infectious diseases, Neuronal diseases, Reproductive diseases, Respiratory diseases

Aliases & Classifications for Borderline Leprosy

MalaCards integrated aliases for Borderline Leprosy:

Name: Borderline Leprosy 12 15 17 71 32
Midborderline Leprosy 12 71
Borderline or Dimorphous Leprosy 12
Leprosy, Borderline 43

Classifications:



External Ids:

Disease Ontology 12 DOID:1023
ICD9CM 34 030.3
MeSH 43 D015439
SNOMED-CT 67 400008009
ICD10 32 A30.3
UMLS 71 C0023346 C3251797

Summaries for Borderline Leprosy

Disease Ontology : 12 A leprosy that results in small numerous red irregularly shaped plaques.

MalaCards based summary : Borderline Leprosy, also known as midborderline leprosy, is related to leprosy 3 and tuberculoid leprosy. An important gene associated with Borderline Leprosy is NOS2 (Nitric Oxide Synthase 2). Affiliated tissues include skin, testes and t cells.

Related Diseases for Borderline Leprosy

Diseases related to Borderline Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 leprosy 3 31.0 SDHD MLLT1 FCN2 CD40LG CCDC122
2 tuberculoid leprosy 30.5 SDHD CD40LG
3 sporotrichosis 29.6 MASP2 CD40LG
4 hansen's disease 10.9
5 lepromatous leprosy 10.4
6 radial nerve lesion 10.1 TOR1B CCDC122
7 allergic hypersensitivity disease 10.1
8 neuritis 10.1
9 laryngitis 10.1 MIR500A CD40LG
10 cranial nerve palsy 10.1 SDHD CD40LG
11 sarcoidosis 1 10.0
12 skin disease 10.0
13 cytokine deficiency 10.0
14 granulocytopenia 10.0
15 persistent generalized lymphadenopathy 10.0 SDHD CD40LG
16 collagenous colitis 10.0 NOS2 CD40LG
17 gilbert syndrome 9.9
18 hepatitis c virus 9.9
19 leprosy 6 9.9
20 exanthem 9.9
21 lymphoma 9.9
22 portal hypertension 9.9
23 neutropenia 9.9
24 guillain-barre syndrome 9.9
25 lagophthalmos 9.9
26 polyneuropathy 9.9
27 urticaria 9.9
28 lymphadenitis 9.9
29 histoplasmosis 9.9
30 cheilitis 9.9
31 pulmonary tuberculosis 9.9
32 chronic granulomatous disease 9.9
33 granulomatous dermatitis 9.9
34 arthritis 9.9
35 neurofibromatosis 9.9
36 dermatophytosis 9.9
37 pityriasis versicolor 9.9
38 neurofibroma 9.9
39 tenosynovitis 9.9
40 alopecia 9.9
41 follicular mucinosis 9.9
42 granulomatous slack skin disease 9.9
43 progressive relapsing multiple sclerosis 9.7 MASP2 FCN2
44 lymph node disease 9.7 SDHD CD40LG
45 peripheral nervous system disease 9.6 SDHD MLLT1 CD40LG
46 3mc syndrome 9.6 MASP2 FCN2
47 chagas disease 9.6 NOS2 MASP2 FCN2
48 rheumatic fever 9.5 MASP2 FCN2 CD40LG
49 indeterminate leprosy 9.4 TOR1B SDHD MLLT1 CD40LG CCDC122
50 testicular disease 9.1 SDHD MLLT1 MIR181A1 CD40LG CCDC122

Graphical network of the top 20 diseases related to Borderline Leprosy:



Diseases related to Borderline Leprosy

Symptoms & Phenotypes for Borderline Leprosy

Drugs & Therapeutics for Borderline Leprosy

Search Clinical Trials , NIH Clinical Center for Borderline Leprosy

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Clofazimine

Cochrane evidence based reviews: leprosy, borderline

Genetic Tests for Borderline Leprosy

Anatomical Context for Borderline Leprosy

MalaCards organs/tissues related to Borderline Leprosy:

40
Skin, Testes, T Cells, Lymph Node, Thyroid, Neutrophil, Prostate

Publications for Borderline Leprosy

Articles related to Borderline Leprosy:

(show top 50) (show all 256)
# Title Authors PMID Year
1
Type 2 leprosy reaction resembling Sweet syndrome: Review of new and published cases. 61
31984474 2020
2
The impact of KIR/HLA genes on the risk of developing multibacillary leprosy. 61
31525196 2019
3
Mid borderline leprosy in type Bα Blaschko linear pattern: a rare phenomenon. 61
30345504 2019
4
A Case of Dapsone-Induced Severe Agranulocytosis Causing Life-Threatening Skin Sepsis in a Sri Lankan Child with Borderline Leprosy: A Success Story! 61
31198424 2019
5
Erythema Nodosum Leprosum Triggered by Antecedent Influenza Vaccine and Respiratory Tract Infection: A Case Report. 61
30326738 2019
6
Mid-borderline leprosy masquerading as an overlap syndrome. 61
29718382 2018
7
A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction? 61
29262820 2017
8
Nerve Damage in Young Patients with Leprosy Diagnosed in an Endemic Area of the Brazilian Amazon: A Cross-Sectional Study. 61
28285750 2017
9
Addition of Mycobacterium indicus pranii vaccine as an immunotherapeutic to standard chemotherapy in borderline leprosy: a double-blind study to assess clinical improvement (preliminary report). 61
27518926 2017
10
Spatial clustering and local risk of leprosy in São Paulo, Brazil. 61
28241038 2017
11
Multiple nerve abscesses: An unusual manifestation of lepra reaction in a patient with borderline leprosy. 61
27841214 2016
12
Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum. 61
27556927 2016
13
[Borderline leprosy as a rare differential diagnosis]. 61
27254633 2016
14
Profile of Rheumatological Manifestations in Leprosy in a Tertiary Care Hospital from Himachal Pradesh. 61
29741821 2016
15
Is CXCL10/CXCR3 axis overexpression a better indicator of leprosy type 1 reaction than inducible nitric oxide synthase? 61
26831417 2015
16
Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil. 61
25605482 2015
17
Evaluation of apoptosis in skin biopsies of patients of borderline leprosy and lepra type 1 reaction. 61
25657399 2015
18
Tuberculous lymphadenitis and borderline leprosy in a patient with isolated unconjugated hyperbilirubinaemia. 61
25385559 2014
19
Evaluation of key histologic variables in skin biopsies of patients of borderline leprosy with type 1 lepra reaction. 61
25201839 2014
20
NFκB activation in cutaneous lesions of leprosy is associated with development of multibacillary infection. 61
25258550 2014
21
Clinical observations in leprosy cases treated at Diamer district of Gilgit-Baltistan, Pakistan. 61
24392530 2013
22
Non pitting edema, arthritis and ichthyosis; presenting manifestation of leprosy. 61
24236367 2013
23
Mid-borderline leprosy. 61
23741685 2013
24
Borderline leprosy masquerading as cheilitis granulomatosa: a case report. 61
23741887 2013
25
[Leprosy-related disabilities after release from multidrug treatment: prevalence and spatial distribution]. 61
23358621 2012
26
Anti-cyclic citrullinated peptide antibodies and rheumatoid factor sera titers in leprosy patients from Mexico. 61
22083616 2012
27
Clinical and histopathological evaluation of the effect of addition of immunotherapy with Mw vaccine to standard chemotherapy in borderline leprosy. 61
23720894 2012
28
Diabetic status of patients with leprosy in Kuwait. 61
23164565 2012
29
Is there a relation between hemicrania continua and leprosy? 61
23720896 2012
30
Clofazimine-induced Hair Pigmentation. 61
23180930 2012
31
Essential role of hormone-sensitive lipase (HSL) in the maintenance of lipid storage in Mycobacterium leprae-infected macrophages. 61
22553833 2012
32
Leprosy patients: neurotrophic factors and axonal markers in skin lesions. 61
22510739 2012
33
A case of borderline leprosy presenting with urticaria-like eruptions: are there lessons to be learned for allergists? 61
21988321 2011
34
Early diagnosis of relapse in borderline leprosy: two case reports. 61
22183459 2011
35
Social participation of people affected by leprosy after discontinuation of multidrug therapy. 61
21644472 2011
36
Micropathological changes in the sub-epidermal zone of normal appearing skin in leprosy. 61
21424049 2011
37
Histopathological changes in the arrector pili muscle of normal appearing skin in leprosy patients. 61
20207571 2010
38
[Serological and cellular reactivity to mycobacterial proteins in Hansen's disease]. 61
21305770 2010
39
Oro-facial aspects of leprosy: report of two cases with literature review. 61
20038902 2010
40
Concomittant pulmonary tuberculosis and borderline leprosy with type-II lepra reaction in single patient. 61
20539766 2010
41
Analysis of newly detected leprosy cases and misdiagnosis in Wuhan (1990-2004). 61
20306639 2009
42
HLA-DR and HLA-DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance. 61
19698125 2009
43
Leprosy: a diagnostic trap for dermatopathologists in nonendemic area. 61
19590409 2009
44
SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy. 61
19460328 2009
45
Phimosis and scrotal lesions in leprosy: two case reports. 61
19842435 2009
46
Granulomatous slack skin clinically and histologically masquerading as borderline leprosy in its early stages. 61
19171548 2009
47
Intraneural injection of corticosteroids to treat nerve damage in leprosy: a case report and review of literature. 61
19068123 2008
48
Type I reaction in a borderline leprosy case successfully treated with multidrug therapy and ofloxacin. 61
18986365 2008
49
Two microbiological relapses in a patient with lepromatous leprosy. 61
19009984 2008
50
Erythrocyte glutathione peroxidase, glutathione reductase activities and blood glutathione content in leprosy. 61
18440071 2008

Variations for Borderline Leprosy

Expression for Borderline Leprosy

Search GEO for disease gene expression data for Borderline Leprosy.

Pathways for Borderline Leprosy

GO Terms for Borderline Leprosy

Biological processes related to Borderline Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 complement activation, lectin pathway GO:0001867 8.62 MASP2 FCN2

Sources for Borderline Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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