MCID: BRD005
MIFTS: 33

Borderline Leprosy

Categories: Endocrine diseases, Eye diseases, Infectious diseases, Neuronal diseases, Reproductive diseases, Respiratory diseases

Aliases & Classifications for Borderline Leprosy

MalaCards integrated aliases for Borderline Leprosy:

Name: Borderline Leprosy 12 15 17 72 33
Midborderline Leprosy 12 72
Borderline or Dimorphous Leprosy 12
Leprosy, Borderline 44

Classifications:



External Ids:

Disease Ontology 12 DOID:1023
ICD9CM 35 030.3
MeSH 44 D015439
SNOMED-CT 68 50521002
ICD10 33 A30.3
UMLS 72 C0023346 C3251797

Summaries for Borderline Leprosy

Disease Ontology : 12 A leprosy that results in small numerous red irregularly shaped plaques.

MalaCards based summary : Borderline Leprosy, also known as midborderline leprosy, is related to leprosy 3 and tuberculoid leprosy. An important gene associated with Borderline Leprosy is NOS2 (Nitric Oxide Synthase 2), and among its related pathways/superpathways is Photodynamic therapy-induced NF-kB survival signaling. The drugs Clofazimine and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and eye, and related phenotype is mortality/aging.

Wikipedia : 75 Borderline leprosy is a cutaneous skin condition with numerous skin lesions that are red irregularly... more...

Related Diseases for Borderline Leprosy

Diseases related to Borderline Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 50)
# Related Disease Score Top Affiliating Genes
1 leprosy 3 32.1 SDHD MLLT1
2 tuberculoid leprosy 30.5 SDHD MLLT1
3 hansen's disease 10.9
4 lepromatous leprosy 10.4
5 allergic hypersensitivity disease 10.1
6 neuritis 10.1
7 retinal vasculitis 10.0 NOS2 APOH
8 sarcoidosis 1 10.0
9 skin disease 10.0
10 cytokine deficiency 10.0
11 granulocytopenia 10.0
12 testicular disease 10.0 SDHD MLLT1
13 upper respiratory tract disease 9.9 SDHD MLLT1
14 gilbert syndrome 9.9
15 leprosy 6 9.9
16 exanthem 9.9
17 lymphoma 9.9
18 portal hypertension 9.9
19 neutropenia 9.9
20 guillain-barre syndrome 9.9
21 lagophthalmos 9.9
22 polyneuropathy 9.9
23 urticaria 9.9
24 lymphadenitis 9.9
25 cheilitis 9.9
26 pulmonary tuberculosis 9.9
27 chronic granulomatous disease 9.9
28 granulomatous dermatitis 9.9
29 arthritis 9.9
30 tenosynovitis 9.9
31 alopecia 9.9
32 follicular mucinosis 9.9
33 granulomatous slack skin disease 9.9
34 sporotrichosis 9.9
35 histoplasmosis 9.9
36 dermatophytosis 9.9
37 pityriasis versicolor 9.9
38 peripheral nervous system disease 9.8 SDHD MLLT1
39 persistent generalized lymphadenopathy 9.8 SDHD CD40LG
40 erythema infectiosum 9.7 CD40LG APOH
41 catastrophic antiphospholipid syndrome 9.7 CD40LG APOH
42 antiphospholipid syndrome 9.7 CD40LG APOH
43 vasculitis 9.6 CD40LG APOH
44 myocarditis 9.6 NOS2 CD40LG
45 legg-calve-perthes disease 9.6 CD40LG APOH
46 syphilis 9.6 CD40LG APOH
47 autoimmune disease 9.5 CD40LG APOH
48 autoimmune disease of musculoskeletal system 9.5 CD40LG APOH
49 rheumatic disease 9.3 CD40LG APOH
50 connective tissue disease 9.1 CD40LG APOH

Graphical network of the top 20 diseases related to Borderline Leprosy:



Diseases related to Borderline Leprosy

Symptoms & Phenotypes for Borderline Leprosy

MGI Mouse Phenotypes related to Borderline Leprosy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.1 APOH CD40LG KIAA1109 MLLT1 NOS2 SDHD

Drugs & Therapeutics for Borderline Leprosy

Drugs for Borderline Leprosy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clofazimine Approved, Investigational Phase 4 2030-63-9 2794
2 Anti-Bacterial Agents Phase 4
3 Vitamins Phase 4
4 Anti-Inflammatory Agents Phase 4
5 Anti-Infective Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Additional Clofazimine on ENL Reactions in Leprosy Completed NCT01290744 Phase 4 Clofazimine;Placebo

Search NIH Clinical Center for Borderline Leprosy

Inferred drug relations via UMLS 72 / NDF-RT 51 :


Clofazimine

Cochrane evidence based reviews: leprosy, borderline

Genetic Tests for Borderline Leprosy

Anatomical Context for Borderline Leprosy

MalaCards organs/tissues related to Borderline Leprosy:

41
Skin, Testes, Eye, T Cells, Lymph Node, Thyroid, Neutrophil

Publications for Borderline Leprosy

Articles related to Borderline Leprosy:

(show top 50) (show all 254)
# Title Authors PMID Year
1
Mid borderline leprosy in type Bα Blaschko linear pattern: a rare phenomenon. 38
30345504 2019
2
A Case of Dapsone-Induced Severe Agranulocytosis Causing Life-Threatening Skin Sepsis in a Sri Lankan Child with Borderline Leprosy: A Success Story! 38
31198424 2019
3
Erythema Nodosum Leprosum Triggered by Antecedent Influenza Vaccine and Respiratory Tract Infection: A Case Report. 38
30326738 2019
4
Mid-borderline leprosy masquerading as an overlap syndrome. 38
29718382 2018
5
A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction? 38
29262820 2017
6
Nerve Damage in Young Patients with Leprosy Diagnosed in an Endemic Area of the Brazilian Amazon: A Cross-Sectional Study. 38
28285750 2017
7
Addition of Mycobacterium indicus pranii vaccine as an immunotherapeutic to standard chemotherapy in borderline leprosy: a double-blind study to assess clinical improvement (preliminary report). 38
27518926 2017
8
Spatial clustering and local risk of leprosy in São Paulo, Brazil. 38
28241038 2017
9
Multiple nerve abscesses: An unusual manifestation of lepra reaction in a patient with borderline leprosy. 38
27841214 2016
10
Expression of CD64 on Circulating Neutrophils Favoring Systemic Inflammatory Status in Erythema Nodosum Leprosum. 38
27556927 2016
11
[Borderline leprosy as a rare differential diagnosis]. 38
27254633 2016
12
Profile of Rheumatological Manifestations in Leprosy in a Tertiary Care Hospital from Himachal Pradesh. 38
29741821 2016
13
Is CXCL10/CXCR3 axis overexpression a better indicator of leprosy type 1 reaction than inducible nitric oxide synthase? 38
26831417 2015
14
Evaluation of apoptosis in skin biopsies of patients of borderline leprosy and lepra type 1 reaction. 38
25657399 2015
15
Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil. 38
25605482 2015
16
Tuberculous lymphadenitis and borderline leprosy in a patient with isolated unconjugated hyperbilirubinaemia. 38
25385559 2014
17
Evaluation of key histologic variables in skin biopsies of patients of borderline leprosy with type 1 lepra reaction. 38
25201839 2014
18
NFκB activation in cutaneous lesions of leprosy is associated with development of multibacillary infection. 38
25258550 2014
19
Clinical observations in leprosy cases treated at Diamer district of Gilgit-Baltistan, Pakistan. 38
24392530 2013
20
Non pitting edema, arthritis and ichthyosis; presenting manifestation of leprosy. 38
24236367 2013
21
Mid-borderline leprosy. 38
23741685 2013
22
Borderline leprosy masquerading as cheilitis granulomatosa: a case report. 38
23741887 2013
23
[Leprosy-related disabilities after release from multidrug treatment: prevalence and spatial distribution]. 38
23358621 2012
24
Anti-cyclic citrullinated peptide antibodies and rheumatoid factor sera titers in leprosy patients from Mexico. 38
22083616 2012
25
Clinical and histopathological evaluation of the effect of addition of immunotherapy with Mw vaccine to standard chemotherapy in borderline leprosy. 38
23720894 2012
26
Diabetic status of patients with leprosy in Kuwait. 38
23164565 2012
27
Is there a relation between hemicrania continua and leprosy? 38
23720896 2012
28
Clofazimine-induced Hair Pigmentation. 38
23180930 2012
29
Essential role of hormone-sensitive lipase (HSL) in the maintenance of lipid storage in Mycobacterium leprae-infected macrophages. 38
22553833 2012
30
Leprosy patients: neurotrophic factors and axonal markers in skin lesions. 38
22510739 2012
31
A case of borderline leprosy presenting with urticaria-like eruptions: are there lessons to be learned for allergists? 38
21988321 2011
32
Early diagnosis of relapse in borderline leprosy: two case reports. 38
22183459 2011
33
Social participation of people affected by leprosy after discontinuation of multidrug therapy. 38
21644472 2011
34
Micropathological changes in the sub-epidermal zone of normal appearing skin in leprosy. 38
21424049 2011
35
[Serological and cellular reactivity to mycobacterial proteins in Hansen's disease]. 38
21305770 2010
36
Histopathological changes in the arrector pili muscle of normal appearing skin in leprosy patients. 38
20207571 2010
37
Oro-facial aspects of leprosy: report of two cases with literature review. 38
20038902 2010
38
Concomittant pulmonary tuberculosis and borderline leprosy with type-II lepra reaction in single patient. 38
20539766 2010
39
Analysis of newly detected leprosy cases and misdiagnosis in Wuhan (1990-2004). 38
20306639 2009
40
Leprosy: a diagnostic trap for dermatopathologists in nonendemic area. 38
19590409 2009
41
HLA-DR and HLA-DQ alleles in patients from the south of Brazil: markers for leprosy susceptibility and resistance. 38
19698125 2009
42
SNP 668C (-44) alters a NF-kappaB1 putative binding site in non-coding strand of human beta-defensin 1 (DEFB1) and is associated with lepromatous leprosy. 38
19460328 2009
43
Phimosis and scrotal lesions in leprosy: two case reports. 38
19842435 2009
44
Granulomatous slack skin clinically and histologically masquerading as borderline leprosy in its early stages. 38
19171548 2009
45
Intraneural injection of corticosteroids to treat nerve damage in leprosy: a case report and review of literature. 38
19068123 2008
46
Type I reaction in a borderline leprosy case successfully treated with multidrug therapy and ofloxacin. 38
18986365 2008
47
Two microbiological relapses in a patient with lepromatous leprosy. 38
19009984 2008
48
Erythrocyte glutathione peroxidase, glutathione reductase activities and blood glutathione content in leprosy. 38
18440071 2008
49
The histological diagnosis of leprosy type 1 reactions: identification of key variables and an analysis of the process of histological diagnosis. 38
18326022 2008
50
Leprosy reversal reaction as immune reconstitution inflammatory syndrome in patients with AIDS. 38
18269334 2008

Variations for Borderline Leprosy

Expression for Borderline Leprosy

Search GEO for disease gene expression data for Borderline Leprosy.

Pathways for Borderline Leprosy

Pathways related to Borderline Leprosy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.42 NOS2 CD40LG

GO Terms for Borderline Leprosy

Molecular functions related to Borderline Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.62 SDHD NOS2

Sources for Borderline Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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