MCID: BRD005
MIFTS: 31

Borderline Leprosy

Categories: Infectious diseases

Aliases & Classifications for Borderline Leprosy

MalaCards integrated aliases for Borderline Leprosy:

Name: Borderline Leprosy 12 15 73
Midborderline Leprosy 12 73
Borderline or Dimorphous Leprosy 12
Leprosy, Borderline 44

Classifications:



External Ids:

Disease Ontology 12 DOID:1023
ICD10 33 A30.3
ICD9CM 35 030.3
MeSH 44 D015439
SNOMED-CT 68 400008009 50521002

Summaries for Borderline Leprosy

Disease Ontology : 12 A leprosy that results in small numerous red irregularly shaped plaques.

MalaCards based summary : Borderline Leprosy, also known as midborderline leprosy, is related to tuberculoid leprosy and leprosy 3. An important gene associated with Borderline Leprosy is NOS2 (Nitric Oxide Synthase 2), and among its related pathways/superpathways are Toxoplasmosis and Photodynamic therapy-induced NF-kB survival signaling. Affiliated tissues include skin, testes and t cells, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 Borderline leprosy is a cutaneous skin condition with numerous skin lesions that are red irregularly... more...

Related Diseases for Borderline Leprosy

Diseases related to Borderline Leprosy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 tuberculoid leprosy 30.4 MLLT1 SDHD
2 leprosy 3 29.5 CD40LG MLLT1 SDHD
3 indeterminate leprosy 10.1 CD40LG MLLT1
4 chlamydia 10.1 CD40LG NOS2
5 primary bacterial infectious disease 10.0 CD40LG MLLT1
6 persistent generalized lymphadenopathy 10.0 CD40LG SDHD
7 type i 10.0
8 myocarditis 10.0 CD40LG NOS2
9 lymph node disease 10.0 CD40LG SDHD
10 lymphatic system disease 10.0 CD40LG SDHD
11 central nervous system disease 9.9 CD40LG NOS2
12 neuritis 9.9
13 retinal vasculitis 9.9 APOH NOS2
14 nervous system disease 9.9 CD40LG NOS2
15 viral exanthem 9.8 APOH CD40LG
16 livedoid vasculopathy 9.8 APOH CD40LG
17 erythema infectiosum 9.8 APOH CD40LG
18 catastrophic antiphospholipid syndrome 9.8 APOH CD40LG
19 branch retinal artery occlusion 9.8 APOH CD40LG
20 arthritis 9.8
21 hepatitis 9.8
22 lymphoma 9.8
23 portal hypertension 9.8
24 lepromatous leprosy 9.8
25 urticaria 9.8
26 lymphadenitis 9.8
27 cheilitis 9.8
28 pulmonary tuberculosis 9.8
29 granulomatous slack skin disease 9.8
30 hansen's disease 9.8
31 syphilis 9.7 APOH CD40LG
32 acrocallosal syndrome 9.7 APOH CD40LG
33 temporal arteritis 9.7 APOH CD40LG
34 antiphospholipid syndrome 9.7 APOH CD40LG
35 hypersensitivity reaction disease 9.6 APOH CD40LG
36 purpura 9.6 APOH CD40LG
37 rheumatic disease 9.6 APOH CD40LG
38 immune system disease 9.6 APOH CD40LG
39 vasculitis 9.5 APOH CD40LG
40 connective tissue disease 9.3 APOH CD40LG
41 behcet syndrome 9.2 APOH CD40LG
42 lupus erythematosus 9.0 APOH CD40LG

Graphical network of the top 20 diseases related to Borderline Leprosy:



Diseases related to Borderline Leprosy

Symptoms & Phenotypes for Borderline Leprosy

GenomeRNAi Phenotypes related to Borderline Leprosy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.4 MLLT1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.4 SDHD APOH MLLT1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.4 SDHD
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-179 9.4 APOH
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.4 SDHD
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.4 SDHD
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-55 9.4 APOH
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.4 MLLT1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.4 MLLT1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.4 MLLT1

MGI Mouse Phenotypes related to Borderline Leprosy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.02 APOH CD40LG MLLT1 NOS2 SDHD

Drugs & Therapeutics for Borderline Leprosy

Search Clinical Trials , NIH Clinical Center for Borderline Leprosy

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: leprosy, borderline

Genetic Tests for Borderline Leprosy

Anatomical Context for Borderline Leprosy

MalaCards organs/tissues related to Borderline Leprosy:

41
Skin, Testes, T Cells

Publications for Borderline Leprosy

Articles related to Borderline Leprosy:

(show top 50) (show all 80)
# Title Authors Year
1
Mid-borderline leprosy masquerading as an overlap syndrome. ( 29718382 )
2018
2
A case report of erythroderma in a patient with borderline leprosy on reversal reaction: a result of the exacerbated reaction? ( 29262820 )
2017
3
Addition of Mycobacterium indicus pranii (MIP) vaccine as an immunotherapeutic with standard chemotherapy in borderline leprosy: A double blind study to assess clinical improvement (A preliminary report). ( 27518926 )
2016
4
Multiple nerve abscesses: An unusual manifestation of lepra reaction in a patient with borderline leprosy. ( 27841214 )
2016
5
Evaluation of apoptosis in skin biopsies of patients of borderline leprosy and lepra type 1 reaction. ( 25657399 )
2015
6
Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil. ( 25605482 )
2015
7
Evaluation of key histologic variables in skin biopsies of patients of borderline leprosy with type 1 lepra reaction. ( 25201839 )
2014
8
Tuberculous lymphadenitis and borderline leprosy in a patient with isolated unconjugated hyperbilirubinaemia. ( 25385559 )
2014
9
Mid-borderline leprosy. ( 23741685 )
2013
10
Borderline leprosy masquerading as cheilitis granulomatosa: a case report. ( 23741887 )
2013
11
Clinical and histopathological evaluation of the effect of addition of immunotherapy with Mw vaccine to standard chemotherapy in borderline leprosy. ( 23720894 )
2012
12
Early diagnosis of relapse in borderline leprosy: two case reports. ( 22183459 )
2011
13
A case of borderline leprosy presenting with urticaria-like eruptions: are there lessons to be learned for allergists? ( 21988321 )
2011
14
Concomittant pulmonary tuberculosis and borderline leprosy with type-II lepra reaction in single patient. ( 20539766 )
2010
15
Granulomatous slack skin clinically and histologically masquerading as borderline leprosy in its early stages. ( 19171548 )
2009
16
Leprosy serology (ML Flow test) in borderline leprosy patients classified as paucibacillary by counting cutaneous lesions: an useful tool. ( 19618075 )
2008
17
Type I reaction in a borderline leprosy case successfully treated with multidrug therapy and ofloxacin. ( 18986365 )
2008
18
Guillain-BarrAc syndrome-like presentation in borderline leprosy with type-2 reaction. ( 16638414 )
2006
19
Chronic inflammatory joint disease revealing borderline leprosy. ( 16213770 )
2006
20
Pitfalls in the cytological classification of borderline leprosy in the Ridley-Jopling scale. ( 15176024 )
2004
21
Nitrotyrosine localization to dermal nerves in borderline leprosy. ( 15030344 )
2004
22
A case report of fatal dapsone-induced agranulocytosis in an Indian mid-borderline leprosy patient. ( 12862258 )
2003
23
Reactions in borderline leprosy. ( 12708730 )
2002
24
Sequential erythema nodosum leprosum and reversal reaction with similar lesional cytokine mRNA patterns in a borderline leprosy patient. ( 11167702 )
2001
25
Expression of inducible nitric oxide synthase and nitrotyrosine in borderline leprosy lesions. ( 11736907 )
2001
26
beta2-Glycoprotein I-dependent anticardiolipin antibodies as risk factor for reactions in borderline leprosy patients. ( 9934366 )
1998
27
Serial Mitsuda tests for identification of reactional tuberculoid and reactional borderline leprosy forms. ( 9728451 )
1998
28
Contribution of type 1 reactions to sensory and motor function loss in borderline leprosy patients and the efficacy of treatment with prednisone. ( 9934360 )
1998
29
Reversal reaction in borderline leprosy is associated with a polarized shift to type 1-like Mycobacterium leprae T cell reactivity in lesional skin: a follow-up study. ( 9379047 )
1997
30
Immunotherapy of lepromin-negative borderline leprosy patients with low-dose Convit vaccine as an adjunct to multidrug therapy; a six-year follow-up study in Calcutta. ( 9207754 )
1997
31
Changes of autonomic nerve function in the first two weeks of acute neuritis in a patient with borderline leprosy. ( 8690978 )
1996
32
Generalized rash in a Dominican immigrant. Borderline leprosy (Hansen's disease) with type 1 upgrading (ie, reversal) reaction. ( 8546490 )
1996
33
Case report: cutaneous lymphoma and borderline leprosy simulating lepromatous leprosy. ( 8684256 )
1996
34
Phenotype and cytokine expression of intralesional cells in borderline leprosy. ( 7963910 )
1994
35
Pathogenesis of generalized nodular type I reaction in a borderline leprosy patient. ( 7714358 )
1994
36
Scrotal lesion in borderline leprosy. ( 8182293 )
1993
37
Risk factors for type-1 reactions in borderline leprosy patients. ( 1679473 )
1991
38
Additional markers for the type I reactional states of borderline leprosy. ( 2393071 )
1990
39
Late onset of a reversal reaction in borderline leprosy. ( 2654221 )
1989
40
Scalp lesions in borderline leprosy. ( 2703742 )
1989
41
A borderline leprosy lesion on the palate: a case report. ( 3398680 )
1988
42
LDH profile in an unusual case of borderline leprosy in reaction associated with portal hypertension. ( 3440847 )
1987
43
Type 1 (reversal) lepra reaction in borderline leprosy with unusual clinical presentation--a case report. ( 3655433 )
1987
44
An unusual bullous reaction in borderline leprosy. ( 3298904 )
1987
45
Unilateral oedema of reversal reaction (RR) in borderline leprosy. ( 3784765 )
1986
46
Multiple relapses in borderline leprosy--a case report. ( 3553362 )
1986
47
Untreated borderline-leprosy in the ulnar nerve: light and electron microscopical studies. ( 2985898 )
1985
48
Immuno-stimulatory effect of levamisole in borderline leprosy cases. ( 3839822 )
1985
49
Lymphocytic infiltration of skin of Jessner-Kanof masquerading as borderline leprosy. ( 3835210 )
1985
50
Borderline leprosy in a three year old child. ( 3831104 )
1985

Variations for Borderline Leprosy

Expression for Borderline Leprosy

Search GEO for disease gene expression data for Borderline Leprosy.

Pathways for Borderline Leprosy

Pathways related to Borderline Leprosy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.23 CD40LG NOS2
2
Show member pathways
10.42 CD40LG NOS2

GO Terms for Borderline Leprosy

Molecular functions related to Borderline Leprosy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heme binding GO:0020037 8.62 NOS2 SDHD

Sources for Borderline Leprosy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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