MCID: BRN018
MIFTS: 36

Borna Disease

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Borna Disease

MalaCards integrated aliases for Borna Disease:

Name: Borna Disease 12 44 15 17 72
Enzootic Encephalomyelitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5154
MeSH 44 D001890
SNOMED-CT 68 76851008
UMLS 72 C0006023

Summaries for Borna Disease

Disease Ontology : 12 A viral infectious disease that results in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in Borna disease virus, which is transmitted by contact with infected oronasal secretions. The infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards based summary : Borna Disease, also known as enzootic encephalomyelitis, is related to encephalitis and meningoencephalitis, and has symptoms including mood disturbances, behaviour disturbances and cognitive disturbances. An important gene associated with Borna Disease is TBK1 (TANK Binding Kinase 1), and among its related pathways/superpathways is Notch Signaling Pathway (sino). Affiliated tissues include brain, t cells and retina, and related phenotype is Increased viability after borna disease (rVSVI9G*/BDVG) virus infection.

Wikipedia : 75 Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease... more...

Related Diseases for Borna Disease

Diseases related to Borna Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 encephalitis 10.7
2 meningoencephalitis 10.6
3 mood disorder 10.5
4 chronic fatigue syndrome 10.5
5 ataxia and polyneuropathy, adult-onset 10.4
6 viral encephalitis 10.4
7 autism 10.3
8 vaccinia 10.3
9 stomatitis 10.3
10 schizophrenia 10.3
11 major affective disorder 8 10.3
12 major affective disorder 9 10.3
13 central nervous system disease 10.3
14 bipolar disorder 10.3
15 nervous system disease 10.3
16 depression 10.3
17 autism spectrum disorder 10.3
18 neuroretinitis 10.3
19 mental depression 10.3
20 oligodendroglioma 10.3
21 retinitis 10.3
22 neuroblastoma 1 10.2
23 rabies 10.2
24 guillain-barre syndrome 10.2
25 measles 10.2
26 immune-mediated encephalomyelitis 10.2
27 yemenite deaf-blind hypopigmentation syndrome 10.1
28 major depressive disorder 10.1
29 visual epilepsy 10.1
30 psychotic disorder 10.1
31 encephalopathy 10.1
32 seizure disorder 10.1
33 rapidly involuting congenital hemangioma 10.1
34 obsessive-compulsive disorder 10.1
35 cerebellar hypoplasia 10.1
36 tardive dyskinesia 10.1
37 hydrocephalus 10.1
38 disease of mental health 10.1
39 glioblastoma multiforme 10.1
40 movement disease 10.1
41 severe combined immunodeficiency 10.1
42 eating disorder 10.1
43 viral infectious disease 10.1
44 allergic encephalomyelitis 10.1
45 congenital hydrocephalus 10.1
46 cytokine deficiency 10.1
47 glioblastoma 10.1
48 brain injury 10.1
49 amyotrophic lateral sclerosis 1 9.9
50 multiple sclerosis 9.9

Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to Borna Disease

Symptoms & Phenotypes for Borna Disease

Symptoms:

12
  • mood disturbances
  • behaviour disturbances
  • cognitive disturbances
  • neurologic disturbances
  • movement impairment

UMLS symptoms related to Borna Disease:


lameness, animal

GenomeRNAi Phenotypes related to Borna Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability after borna disease (rVSVI9G*/BDVG) virus infection GR00192-A 9.28 ABCB5 ADAM17 ADAMTS10 ARHGAP32 AXL CARD9

Drugs & Therapeutics for Borna Disease

Search Clinical Trials , NIH Clinical Center for Borna Disease

Cochrane evidence based reviews: borna disease

Genetic Tests for Borna Disease

Anatomical Context for Borna Disease

MalaCards organs/tissues related to Borna Disease:

41
Brain, T Cells, Retina, Cerebellum, Testes, Cortex, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Borna Disease:

19
Central Nervous System

Publications for Borna Disease

Articles related to Borna Disease:

(show top 50) (show all 844)
# Title Authors PMID Year
1
miR-146a promotes Borna disease virus 1 replication through IRAK1/TRAF6/NF-κB signaling pathway. 38
31330207 2019
2
RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs. 38
31309127 2019
3
The neuropathology of fatal encephalomyelitis in human Borna virus infection. 38
31346692 2019
4
Genome-wide profiling of long noncoding RNA expression patterns and CeRNA analysis in mouse cortical neurons infected with different strains of borna disease virus. 38
31193942 2019
5
Intracellular dynamics of actin affects Borna disease virus replication in the nucleus. 38
30769121 2019
6
The comparative biochemistry of viruses and humans: an evolutionary path towards autoimmunity. 38
30504522 2019
7
Splicing-Dependent Subcellular Targeting of Borna Disease Virus Nucleoprotein Isoforms. 38
30541858 2019
8
Intranasal Borna Disease Virus (BoDV-1) Infection: Insights into Initial Steps and Potential Contagiosity. 38
30875911 2019
9
Constructing RNA Viruses for Long-Term Transcriptional Gene Silencing. 38
30131184 2019
10
The equine species as Trojan horse for Borna Disease Virus-1? 38
30773123 2018
11
2'-Fluoro-2'-deoxycytidine is a broad-spectrum inhibitor of bunyaviruses in vitro and in phleboviral disease mouse models. 38
30339848 2018
12
Fatal Encephalitis Associated with Borna Disease Virus 1. 38
30281979 2018
13
Fatal Encephalitic Borna Disease Virus 1 in Solid-Organ Transplant Recipients. 38
30281984 2018
14
Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector. 38
29771464 2018
15
Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder. 38
29786872 2018
16
The association between Borna Disease Virus and schizophrenia: A systematic review and meta-analysis. 38
29660614 2018
17
Application of antibodies against Borna disease virus phosphoprotein and nucleoprotein on paraffin sections. 38
29363723 2018
18
Studies on immunity and immunopathogenesis of parrot bornaviral disease in cockatiels. 38
29274528 2018
19
Hippocampal expression of a virus-derived protein impairs memory in mice. 38
29378968 2018
20
Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats. 38
30532543 2018
21
Memory Impairment Induced by Borna Disease Virus 1 Infection is Associated with Reduced H3K9 Acetylation. 38
30138929 2018
22
Different inhibitory effects on the proliferation and apoptosis of human and laboratory Borna disease virus‑infected human neuroblastoma SH‑SY5Y cells in vitro. 38
29115502 2018
23
[Crazy horse disease]. 38
31095192 2018
24
Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells. 38
28715652 2017
25
Generation of a non-transmissive Borna disease virus vector lacking both matrix and glycoprotein genes. 38
28776750 2017
26
Antiviral activity of favipiravir (T-705) against mammalian and avian bornaviruses. 38
28465146 2017
27
Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein. 38
28693611 2017
28
Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production. 38
28446679 2017
29
Infections of horses and shrews with Bornaviruses in Upper Austria: a novel endemic area of Borna disease. 38
28634359 2017
30
Primary central nervous system diffuse large B-cell lymphoma shows an activated B-cell-like phenotype with co-expression of C-MYC, BCL-2, and BCL-6. 38
28552541 2017
31
No molecular evidence of Borna disease virus among schizophrenia and bipolar disorder patients in Iran. 38
29214003 2017
32
Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother. 38
27795475 2017
33
Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother. 38
28943599 2017
34
Pathological findings in the red fox (Vulpes vulpes), stone marten (Martes foina) and raccoon dog (Nyctereutes procyonoides), with special emphasis on infectious and zoonotic agents in Northern Germany. 38
28399176 2017
35
The pathogenesis of bornaviral diseases in mammals. 38
27212192 2016
36
Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds. 38
27498995 2016
37
Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus. 38
27803166 2016
38
Neuronal retrograde transport of Borna disease virus occurs in signalling endosomes. 38
27902378 2016
39
Identification of suitable reference genes for BDV-infected primary rat hippocampal neurons. 38
27878262 2016
40
Change in the responsiveness of interferon-stimulated genes during early pregnancy in cows with Borna virus-1 infection. 38
27842550 2016
41
Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. 38
27748825 2016
42
Primary psychosis and Borna disease virus infection in Lithuania: a case control study. 38
27809822 2016
43
Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia. 38
28050187 2016
44
Screening red foxes (Vulpes vulpes) for possible viral causes of encephalitis. 38
27590473 2016
45
Long-term expression of miRNA for RNA interference using a novel vector system based on a negative-strand RNA virus. 38
27189575 2016
46
Endogenous non-retroviral RNA virus elements evidence a novel type of antiviral immunity. 38
27510928 2016
47
Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. 38
26700735 2016
48
A novel intranuclear RNA vector system for long-term stem cell modification. 38
26632671 2016
49
Surface glycoprotein of Borna disease virus mediates virus spread from cell to cell. 38
26332529 2016
50
Expression and role of the TGF-β family in glial cells infected with Borna disease virus. 38
26482505 2016

Variations for Borna Disease

Expression for Borna Disease

Search GEO for disease gene expression data for Borna Disease.

Pathways for Borna Disease

Pathways related to Borna Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.17 TBK1 ADAM17

GO Terms for Borna Disease

Cellular components related to Borna Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome membrane GO:0010008 8.8 TBK1 CHMP1A ARHGAP32

Biological processes related to Borna Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.46 CPA1 CHMP1A ADAMTS10 ADAM17
2 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.26 TBK1 CARD9
3 defense response to virus GO:0051607 9.13 TBK1 PRF1 CARD9
4 defense response to Gram-positive bacterium GO:0050830 8.8 TBK1 CARD9 ADAM17

Molecular functions related to Borna Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.65 TBK1 PRF1 CPA1 CKM CHMP1A CARD9
2 metallopeptidase activity GO:0008237 8.92 CPA1 CHMP1A ADAMTS10 ADAM17

Sources for Borna Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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