MCID: BRN018
MIFTS: 34

Borna Disease

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Borna Disease

MalaCards integrated aliases for Borna Disease:

Name: Borna Disease 12 45 15 17 74
Enzootic Encephalomyelitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5154
MeSH 45 D001890
SNOMED-CT 69 76851008
UMLS 74 C0006023

Summaries for Borna Disease

Disease Ontology : 12 A viral infectious disease that results in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in Borna disease virus, which is transmitted by contact with infected oronasal secretions. The infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards based summary : Borna Disease, also known as enzootic encephalomyelitis, is related to schizophrenia and encephalitis, and has symptoms including mood disturbances, behaviour disturbances and cognitive disturbances. An important gene associated with Borna Disease is TBK1 (TANK Binding Kinase 1). Affiliated tissues include brain, t cells and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease... more...

Related Diseases for Borna Disease

Diseases related to Borna Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 schizophrenia 10.5
2 encephalitis 10.4
3 chronic fatigue syndrome 10.3
4 autism 10.3
5 depression 10.3
6 mood disorder 10.2
7 multiple sclerosis 10.1
8 disease of mental health 10.1
9 bipolar disorder 10.1
10 brain injury 10.1
11 meningoencephalitis 10.1
12 rabies 10.1
13 amyotrophic lateral sclerosis 1 9.9
14 obsessive-compulsive disorder 9.9
15 neuroblastoma 1 9.9
16 panencephalitis, subacute sclerosing 9.9
17 human immunodeficiency virus type 1 9.9
18 leukemia 9.9
19 chlamydia pneumonia 9.9
20 autism spectrum disorder 9.9
21 chlamydia 9.9
22 dementia 9.9
23 epilepsy 9.9
24 lateral sclerosis 9.9
25 psychotic disorder 9.9
26 oligodendroglioma 9.9
27 retinitis 9.9
28 movement disease 9.9
29 human immunodeficiency virus infectious disease 9.9
30 dystonia 9.9
31 fibromyalgia 9.9
32 viral encephalitis 9.9
33 t-cell leukemia 9.9
34 influenza 9.9
35 stomatitis 9.9
36 allergic encephalomyelitis 9.9
37 human t-cell leukemia virus type 1 9.9
38 encephalopathy 9.9

Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to Borna Disease

Symptoms & Phenotypes for Borna Disease

Symptoms:

12
  • mood disturbances
  • behaviour disturbances
  • cognitive disturbances
  • neurologic disturbances
  • movement impairment

UMLS symptoms related to Borna Disease:


lameness, animal

GenomeRNAi Phenotypes related to Borna Disease according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.73 HIPK4
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-15 9.73 MMP21
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.73 HIPK4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.73 PRF1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-213 9.73 MMP21
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.73 PRF1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.73 MMP21
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.73 HIPK4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.73 PRF1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.73 HIPK4 MMP21 PRF1
11 Increased viability after borna disease (rVSVI9G*/BDVG) virus infection GR00192-A 9.28 HIPK4 MMP21 PDE3A PNMT PRSS38 PTDSS1

Drugs & Therapeutics for Borna Disease

Search Clinical Trials , NIH Clinical Center for Borna Disease

Cochrane evidence based reviews: borna disease

Genetic Tests for Borna Disease

Anatomical Context for Borna Disease

MalaCards organs/tissues related to Borna Disease:

42
Brain, T Cells, Bone, Cerebellum, Retina, Cortex, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Borna Disease:

20
Central Nervous System

Publications for Borna Disease

Articles related to Borna Disease:

(show top 50) (show all 641)
# Title Authors Year
1
Intracellular dynamics of actin affects Borna disease virus replication in the nucleus. ( 30769121 )
2019
2
Intranasal Borna Disease Virus (BoDV-1) Infection: Insights into Initial Steps and Potential Contagiosity. ( 30875911 )
2019
3
Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder. ( 29786872 )
2018
4
Different inhibitory effects on the proliferation and apoptosis of human and laboratory Borna disease virus‑infected human neuroblastoma SH‑SY5Y cells in vitro. ( 29115502 )
2018
5
Application of antibodies against Borna disease virus phosphoprotein and nucleoprotein on paraffin sections. ( 29363723 )
2018
6
The association between Borna Disease Virus and schizophrenia: A systematic review and meta-analysis. ( 29660614 )
2018
7
Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector. ( 29771464 )
2018
8
Memory Impairment Induced by Borna Disease Virus 1 Infection is Associated with Reduced H3K9 Acetylation. ( 30138929 )
2018
9
Fatal Encephalitis Associated with Borna Disease Virus 1. ( 30281979 )
2018
10
Fatal Encephalitic Borna Disease Virus 1 in Solid-Organ Transplant Recipients. ( 30281984 )
2018
11
Splicing-Dependent Subcellular Targeting of Borna Disease Virus Nucleoprotein Isoforms. ( 30541858 )
2018
12
The equine species as Trojan horse for Borna Disease Virus-1? ( 30773123 )
2018
13
No molecular evidence of Borna disease virus among schizophrenia and bipolar disorder patients in Iran. ( 29214003 )
2017
14
Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother. ( 27795475 )
2017
15
Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production. ( 28446679 )
2017
16
Infections of horses and shrews with Bornaviruses in Upper Austria: a novel endemic area of Borna disease. ( 28634359 )
2017
17
Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein. ( 28693611 )
2017
18
Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells. ( 28715652 )
2017
19
Generation of a non-transmissive Borna disease virus vector lacking both matrix and glycoprotein genes. ( 28776750 )
2017
20
Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother. ( 28943599 )
2017
21
Surface glycoprotein of Borna disease virus mediates virus spread from cell to cell. ( 26332529 )
2016
22
Expression and role of the TGF-β family in glial cells infected with Borna disease virus. ( 26482505 )
2016
23
Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. ( 26700735 )
2016
24
Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds. ( 27498995 )
2016
25
Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. ( 27748825 )
2016
26
Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus. ( 27803166 )
2016
27
Primary psychosis and Borna disease virus infection in Lithuania: a case control study. ( 27809822 )
2016
28
Neuronal retrograde transport of Borna disease virus occurs in signalling endosomes. ( 27902378 )
2016
29
Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia. ( 28050187 )
2016
30
Borna disease virus infection impacts microRNAs associated with nervous system development, cell differentiation, proliferation and apoptosis in the hippocampi of neonatal rats. ( 26004383 )
2015
31
Borna disease virus infection in cats: ABCD guidelines on prevention and management. ( 26101313 )
2015
32
Persistent human Borna disease virus infection modifies the acetylome of human oligodendroglia cells towards higher energy and transporter levels. ( 26210075 )
2015
33
GC-MS-Based Metabonomic Profiling Displayed Differing Effects of Borna Disease Virus Natural Strain Hu-H1 and Laboratory Strain V Infection in Rat Cortical Neurons. ( 26287181 )
2015
34
Shedding of Infectious Borna Disease Virus-1 in Living Bicolored White-Toothed Shrews. ( 26313904 )
2015
35
X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virus nuclear viral factories. ( 26333388 )
2015
36
Borna disease virus phosphoprotein impairs the developmental program controlling neurogenesis and reduces human GABAergic neurogenesis. ( 25923687 )
2015
37
Health care professionals at risk of infection with Borna disease virus - evidence from a large hospital in China (Chongqing). ( 25888756 )
2015
38
Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. ( 25810554 )
2015
39
Borna disease virus possesses an NF-ĸB inhibitory sequence in the nucleoprotein gene. ( 25733193 )
2015
40
Discrepancy in the diagnosis of avian Borna disease virus infection of Psittaciformes by protein analysis of feather calami and enzyme-linked immunosorbent assay of plasma antibodies. ( 25701023 )
2015
41
Neuropathogenesis of persistent infection with Borna disease virus. ( 26923969 )
2015
42
Evidence for Borna disease virus infection in neuropsychiatric patients in three western China provinces. ( 24170181 )
2014
43
Borna disease virus infection in cats. ( 24480411 )
2014
44
Evidence for natural Borna disease virus infection in healthy domestic animals in three areas of western China. ( 24573218 )
2014
45
Proteomics reveal energy metabolism and mitogen-activated protein kinase signal transduction perturbation in human Borna disease virus Hu-H1-infected oligodendroglial cells. ( 24637096 )
2014
46
The bicolored white-toothed shrew Crocidura leucodon (HERMANN 1780) is an indigenous host of mammalian Borna disease virus. ( 24699636 )
2014
47
A study on Borna disease virus infection in domestic cats in Japan. ( 24805904 )
2014
48
Glutamate and lipid metabolic perturbation in the hippocampi of asymptomatic borna disease virus-infected horses. ( 24956478 )
2014
49
Human borna disease virus infection impacts host proteome and histone lysine acetylation in human oligodendroglia cells. ( 25086498 )
2014
50
Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome. ( 25157155 )
2014

Variations for Borna Disease

Expression for Borna Disease

Search GEO for disease gene expression data for Borna Disease.

Pathways for Borna Disease

GO Terms for Borna Disease

Sources for Borna Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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