MCID: BRN018
MIFTS: 35

Borna Disease

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Borna Disease

MalaCards integrated aliases for Borna Disease:

Name: Borna Disease 12 43 15 17 71
Enzootic Encephalomyelitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5154
MeSH 43 D001890
SNOMED-CT 67 76851008
UMLS 71 C0006023

Summaries for Borna Disease

Disease Ontology : 12 A viral infectious disease that results in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in Borna disease virus, which is transmitted by contact with infected oronasal secretions. The infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards based summary : Borna Disease, also known as enzootic encephalomyelitis, is related to encephalitis and meningoencephalitis, and has symptoms including mood disturbances, behaviour disturbances and cognitive disturbances. An important gene associated with Borna Disease is TBK1 (TANK Binding Kinase 1), and among its related pathways/superpathways is Notch Signaling Pathway (sino). Affiliated tissues include central nervous system, brain and t cells, and related phenotypes are Increased viability after borna disease (rVSVI9G*/BDVG) virus infection and immune system

Wikipedia : 74 Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease... more...

Related Diseases for Borna Disease

Diseases related to Borna Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 encephalitis 10.7
2 meningoencephalitis 10.6
3 mood disorder 10.5
4 chronic fatigue syndrome 10.5
5 viral encephalitis 10.4
6 schizophrenia 10.3
7 ataxia and polyneuropathy, adult-onset 10.3
8 vaccinia 10.3
9 stomatitis 10.3
10 autism 10.3
11 major affective disorder 8 10.3
12 major affective disorder 9 10.3
13 central nervous system disease 10.3
14 bipolar disorder 10.3
15 nervous system disease 10.3
16 depression 10.3
17 autism spectrum disorder 10.3
18 neuroretinitis 10.3
19 mental depression 10.3
20 oligodendroglioma 10.3
21 retinitis 10.3
22 rabies 10.2
23 guillain-barre syndrome 10.2
24 measles 10.2
25 immune-mediated encephalomyelitis 10.2
26 yemenite deaf-blind hypopigmentation syndrome 10.1
27 major depressive disorder 10.1
28 visual epilepsy 10.1
29 psychotic disorder 10.1
30 neuroblastoma 10.1
31 encephalopathy 10.1
32 seizure disorder 10.1
33 rapidly involuting congenital hemangioma 10.1
34 multiple sclerosis 10.1
35 obsessive-compulsive disorder 10.1
36 ocular motor apraxia 10.1
37 tardive dyskinesia 10.1
38 hydrocephalus 10.1
39 disease of mental health 10.1
40 glioblastoma multiforme 10.1
41 movement disease 10.1
42 severe combined immunodeficiency 10.1
43 eating disorder 10.1
44 viral infectious disease 10.1
45 allergic encephalomyelitis 10.1
46 cerebellar hypoplasia 10.1
47 brain injury 10.1
48 amyotrophic lateral sclerosis 1 9.9
49 parkinson disease, late-onset 9.9
50 torticollis 9.9

Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to Borna Disease

Symptoms & Phenotypes for Borna Disease

Symptoms:

12
  • mood disturbances
  • behaviour disturbances
  • cognitive disturbances
  • neurologic disturbances
  • movement impairment

UMLS symptoms related to Borna Disease:


lameness, animal

GenomeRNAi Phenotypes related to Borna Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability after borna disease (rVSVI9G*/BDVG) virus infection GR00192-A 9.5 A4GNT ABCB5 ABCC10 ABHD11 ADAM17 ADAMTS10

MGI Mouse Phenotypes related to Borna Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.28 A4GNT ABCC10 ADAM17 ALDH3A1 AXL CARD9

Drugs & Therapeutics for Borna Disease

Search Clinical Trials , NIH Clinical Center for Borna Disease

Cochrane evidence based reviews: borna disease

Genetic Tests for Borna Disease

Anatomical Context for Borna Disease

The Foundational Model of Anatomy Ontology organs/tissues related to Borna Disease:

19
Central Nervous System

MalaCards organs/tissues related to Borna Disease:

40
Brain, T Cells, Retina, Cerebellum, Cortex, Testes, Bone Marrow

Publications for Borna Disease

Articles related to Borna Disease:

(show top 50) (show all 851)
# Title Authors PMID Year
1
Zoonotic spillover infections with Borna disease virus 1 leading to fatal human encephalitis, 1999-2019: an epidemiological investigation. 61
31924550 2020
2
No evidence for European bats serving as reservoir for Borna disease virus 1 or other known mammalian orthobornaviruses. 61
32000801 2020
3
ADAR2 is involved in self and nonself recognition of Borna disease virus genomic RNA in the nucleus. 61
31852792 2019
4
Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe? 61
31878129 2019
5
Low prevalence of Borna disease virus 1 (BoDV-1) IgG antibodies in humans from areas endemic for animal Borna disease of Southern Germany. 61
31882942 2019
6
miR-146a promotes Borna disease virus 1 replication through IRAK1/TRAF6/NF-κB signaling pathway. 61
31330207 2019
7
The neuropathology of fatal encephalomyelitis in human Borna virus infection. 61
31346692 2019
8
RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs. 61
31309127 2019
9
Genome-wide profiling of long noncoding RNA expression patterns and CeRNA analysis in mouse cortical neurons infected with different strains of borna disease virus. 61
31193942 2019
10
Intracellular dynamics of actin affects Borna disease virus replication in the nucleus. 61
30769121 2019
11
The comparative biochemistry of viruses and humans: an evolutionary path towards autoimmunity. 61
30504522 2019
12
Splicing-Dependent Subcellular Targeting of Borna Disease Virus Nucleoprotein Isoforms. 61
30541858 2019
13
Intranasal Borna Disease Virus (BoDV-1) Infection: Insights into Initial Steps and Potential Contagiosity. 61
30875911 2019
14
A Small Interfering RNA Cocktail Targeting the Nucleoprotein and Large Protein Genes Suppresses Borna Disease Virus Infection. 61
31849913 2019
15
Constructing RNA Viruses for Long-Term Transcriptional Gene Silencing. 61
30131184 2019
16
Development of an RNA Virus-Based Episomal Vector Capable of Switching Transgene Expression. 61
31781052 2019
17
The equine species as Trojan horse for Borna Disease Virus-1? 61
30773123 2018
18
2'-Fluoro-2'-deoxycytidine is a broad-spectrum inhibitor of bunyaviruses in vitro and in phleboviral disease mouse models. 61
30339848 2018
19
Fatal Encephalitis Associated with Borna Disease Virus 1. 61
30281979 2018
20
Fatal Encephalitic Borna Disease Virus 1 in Solid-Organ Transplant Recipients. 61
30281984 2018
21
Degradation of amyloid β peptide by neprilysin expressed from Borna disease virus vector. 61
29771464 2018
22
Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder. 61
29786872 2018
23
The association between Borna Disease Virus and schizophrenia: A systematic review and meta-analysis. 61
29660614 2018
24
Application of antibodies against Borna disease virus phosphoprotein and nucleoprotein on paraffin sections. 61
29363723 2018
25
Hippocampal expression of a virus-derived protein impairs memory in mice. 61
29378968 2018
26
Studies on immunity and immunopathogenesis of parrot bornaviral disease in cockatiels. 61
29274528 2018
27
Activation of ERK/CREB/BDNF pathway involved in abnormal behavior of neonatally Borna virus-infected rats. 61
30532543 2018
28
Different inhibitory effects on the proliferation and apoptosis of human and laboratory Borna disease virus‑infected human neuroblastoma SH‑SY5Y cells in vitro. 61
29115502 2018
29
Memory Impairment Induced by Borna Disease Virus 1 Infection is Associated with Reduced H3K9 Acetylation. 61
30138929 2018
30
[Crazy horse disease]. 61
31095192 2018
31
Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells. 61
28715652 2017
32
Generation of a non-transmissive Borna disease virus vector lacking both matrix and glycoprotein genes. 61
28776750 2017
33
Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein. 61
28693611 2017
34
Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production. 61
28446679 2017
35
Antiviral activity of favipiravir (T-705) against mammalian and avian bornaviruses. 61
28465146 2017
36
Infections of horses and shrews with Bornaviruses in Upper Austria: a novel endemic area of Borna disease. 61
28634359 2017
37
Primary central nervous system diffuse large B-cell lymphoma shows an activated B-cell-like phenotype with co-expression of C-MYC, BCL-2, and BCL-6. 61
28552541 2017
38
No molecular evidence of Borna disease virus among schizophrenia and bipolar disorder patients in Iran. 61
29214003 2017
39
Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother. 61
27795475 2017
40
Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother. 61
28943599 2017
41
Pathological findings in the red fox (Vulpes vulpes), stone marten (Martes foina) and raccoon dog (Nyctereutes procyonoides), with special emphasis on infectious and zoonotic agents in Northern Germany. 61
28399176 2017
42
The pathogenesis of bornaviral diseases in mammals. 61
27212192 2016
43
Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds. 61
27498995 2016
44
Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus. 61
27803166 2016
45
Neuronal retrograde transport of Borna disease virus occurs in signalling endosomes. 61
27902378 2016
46
Identification of suitable reference genes for BDV-infected primary rat hippocampal neurons. 61
27878262 2016
47
Change in the responsiveness of interferon-stimulated genes during early pregnancy in cows with Borna virus-1 infection. 61
27842550 2016
48
Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. 61
27748825 2016
49
Primary psychosis and Borna disease virus infection in Lithuania: a case control study. 61
27809822 2016
50
Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia. 61
28050187 2016

Variations for Borna Disease

Expression for Borna Disease

Search GEO for disease gene expression data for Borna Disease.

Pathways for Borna Disease

Pathways related to Borna Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.34 TBK1 FURIN ADAM17

GO Terms for Borna Disease

Cellular components related to Borna Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endosome membrane GO:0010008 8.92 TBK1 FURIN CHMP1A ARHGAP32

Biological processes related to Borna Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 defense response to Gram-positive bacterium GO:0050830 9.13 TBK1 CARD9 ADAM17
2 secretion by cell GO:0032940 8.62 FURIN AXL

Molecular functions related to Borna Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metallopeptidase activity GO:0008237 8.8 CHMP1A ADAMTS10 ADAM17

Sources for Borna Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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