MCID: BRN018
MIFTS: 35

Borna Disease

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Borna Disease

MalaCards integrated aliases for Borna Disease:

Name: Borna Disease 12 44 15 73
Enzootic Encephalomyelitis 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5154
MeSH 44 D001890
SNOMED-CT 68 76851008
UMLS 73 C0006023

Summaries for Borna Disease

Disease Ontology : 12 A viral infectious disease that results in infection, which affects dopaminergic neurotransmission located in central nervous system, has material basis in Borna disease virus, which is transmitted by contact with infected oronasal secretions. The infection has symptom mood disturbances, has symptom behaviour disturbances, has symptom cognitive disturbances, has symptom neurologic disturbances, and has symptom movement impairment.

MalaCards based summary : Borna Disease, also known as enzootic encephalomyelitis, is related to viral infectious disease and schizophrenia, and has symptoms including mood disturbances, behaviour disturbances and cognitive disturbances. An important gene associated with Borna Disease is HSPA5 (Heat Shock Protein Family A (Hsp70) Member 5), and among its related pathways/superpathways is Development_Glucocorticoid receptor signaling. Affiliated tissues include brain, t cells and bone, and related phenotype is Increased viability after borna disease (rVSVI9G*/BDVG) virus infection.

Wikipedia : 76 Borna disease is an infectious neurological syndrome of warm-blooded animals, caused by Borna disease... more...

Related Diseases for Borna Disease

Diseases related to Borna Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 38)
# Related Disease Score Top Affiliating Genes
1 viral infectious disease 10.9
2 schizophrenia 10.5
3 encephalitis 10.4
4 chronic fatigue syndrome 10.3
5 autism 10.2
6 depression 10.2
7 mood disorder 10.2
8 multiple sclerosis 10.1
9 neuroblastoma 10.0
10 bipolar disorder 10.0
11 brain injury 10.0
12 meningoencephalitis 10.0
13 rabies 10.0
14 amyotrophic lateral sclerosis 1 9.9
15 obsessive-compulsive disorder 9.9
16 panencephalitis, subacute sclerosing 9.9
17 human immunodeficiency virus type 1 9.9
18 leukemia 9.9
19 autism spectrum disorder 9.9
20 chlamydia 9.9
21 dementia 9.9
22 disease of mental health 9.9
23 epilepsy 9.9
24 lateral sclerosis 9.9
25 psychotic disorder 9.9
26 oligodendroglioma 9.9
27 retinitis 9.9
28 movement disease 9.9
29 human immunodeficiency virus infectious disease 9.9
30 dystonia 9.9
31 viral encephalitis 9.9
32 t-cell leukemia 9.9
33 influenza 9.9
34 stomatitis 9.9
35 allergic encephalomyelitis 9.9
36 human t-cell leukemia virus type 1 9.9
37 fibromyalgia 9.9
38 encephalopathy 9.9

Graphical network of the top 20 diseases related to Borna Disease:



Diseases related to Borna Disease

Symptoms & Phenotypes for Borna Disease

Symptoms:

12
  • mood disturbances
  • behaviour disturbances
  • cognitive disturbances
  • neurologic disturbances
  • movement impairment

UMLS symptoms related to Borna Disease:


lameness, animal

GenomeRNAi Phenotypes related to Borna Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability after borna disease (rVSVI9G*/BDVG) virus infection GR00192-A 9.28 A4GNT ABHD11 MAP2K7 MMP21 MT-ND4L NCOA2

Drugs & Therapeutics for Borna Disease

Search Clinical Trials , NIH Clinical Center for Borna Disease

Cochrane evidence based reviews: borna disease

Genetic Tests for Borna Disease

Anatomical Context for Borna Disease

MalaCards organs/tissues related to Borna Disease:

41
Brain, T Cells, Bone, Cerebellum, Retina, Cortex, Bone Marrow

The Foundational Model of Anatomy Ontology organs/tissues related to Borna Disease:

19
Central Nervous System

Publications for Borna Disease

Articles related to Borna Disease:

(show top 50) (show all 637)
# Title Authors Year
1
The association between Borna Disease Virus and schizophrenia: A systematic review and meta-analysis. ( 29660614 )
2018
2
Prevalence of antibodies against Borna disease virus proteins in Japanese children with autism spectrum disorder. ( 29786872 )
2018
3
Application of antibodies against Borna disease virus phosphoprotein and nucleoprotein on paraffin sections. ( 29363723 )
2018
4
Degradation of amyloid I^ peptide by neprilysin expressed from Borna disease virus vector. ( 29771464 )
2018
5
Different inhibitory effects on the proliferation and apoptosis of human and laboratory Borna disease virusa89infected human neuroblastoma SHa89SY5Y cells inA vitro. ( 29115502 )
2018
6
Memory Impairment Induced by Borna Disease Virus 1 Infection is Associated with Reduced H3K9 Acetylation. ( 30138929 )
2018
7
Fatal Encephalitis Associated with Borna Disease Virus 1. ( 30281979 )
2018
8
Fatal Encephalitic Borna Disease Virus 1 in Solid-Organ Transplant Recipients. ( 30281984 )
2018
9
Splicing-Dependent Subcellular Targeting of Borna Disease Virus Nucleoprotein Isoforms. ( 30541858 )
2018
10
Linkage between the leader sequence and leader RNA production in Borna disease virus-infected cells. ( 28715652 )
2017
11
No molecular evidence of Borna disease virus among schizophrenia and bipolar disorder patients in Iran. ( 29214003 )
2017
12
Dual function of the nuclear export signal of the Borna disease virus nucleoprotein in nuclear export activity and binding to viral phosphoprotein. ( 28693611 )
2017
13
Infections of horses and shrews with Bornaviruses in Upper Austria: a novel endemic area of Borna disease. ( 28634359 )
2017
14
Central Nervous System Infection with Borna Disease Virus Causes Kynurenine Pathway Dysregulation and Neurotoxic Quinolinic Acid Production. ( 28446679 )
2017
15
Detection of Antibodies against Borna Disease Virus Proteins in an Autistic Child and Her Mother. ( 28943599 )
2017
16
Generation of a non-transmissive Borna disease virus vector lacking both matrix and glycoprotein genes. ( 28776750 )
2017
17
Manipulation of the N-terminal sequence of the Borna disease virus X protein improves its mitochondrial targeting and neuroprotective potential. ( 26700735 )
2016
18
Identification and bioinformatic analysis of dysregulated microRNAs in human oligodendroglial cells infected with borna disease virus. ( 27748825 )
2016
19
Sero-epidemiological analysis of vertical transmission relative risk of Borna disease virus infection in dairy herds. ( 27498995 )
2016
20
Neuronal retrograde transport of Borna disease virus occurs in signalling endosomes. ( 27902378 )
2016
21
Detection of antibodies to Borna disease virus proteins in an autistic child and her mother. ( 27795475 )
2016
22
Detection of Borna Disease Virus (BDV) in Patients with First Episode of Schizophrenia. ( 28050187 )
2016
23
Borna Disease Virus Assembles Porous Cage-like Viral Factories in the Nucleus. ( 27803166 )
2016
24
Primary psychosis and Borna disease virus infection in Lithuania: a case control study. ( 27809822 )
2016
25
Borna disease virus phosphoprotein impairs the developmental program controlling neurogenesis and reduces human GABAergic neurogenesis. ( 25923687 )
2015
26
Borna disease virus possesses an NF-A,B inhibitory sequence in the nucleoprotein gene. ( 25733193 )
2015
27
Borna disease virus infection impacts microRNAs associated with nervous system development, cell differentiation, proliferation and apoptosis in the hippocampi of neonatal rats. ( 26004383 )
2015
28
GC-MS-Based Metabonomic Profiling Displayed Differing Effects of Borna Disease Virus Natural Strain Hu-H1 and Laboratory Strain V Infection in Rat Cortical Neurons. ( 26287181 )
2015
29
Surface glycoprotein of Borna disease virus mediates virus spread from cell to cell. ( 26332529 )
2015
30
Borna disease virus phosphoprotein modulates epigenetic signaling in neurons to control viral replication. ( 25810554 )
2015
31
Neuropathogenesis of persistent infection with Borna disease virus. ( 26923969 )
2015
32
Borna disease virus infection in cats: ABCD guidelines on prevention and management. ( 26101313 )
2015
33
Health care professionals at risk of infection with Borna disease virus - evidence from a large hospital in China (Chongqing). ( 25888756 )
2015
34
Persistent human Borna disease virus infection modifies the acetylome of human oligodendroglia cells towards higher energy and transporter levels. ( 26210075 )
2015
35
Discrepancy in the diagnosis of avian Borna disease virus infection of Psittaciformes by protein analysis of feather calami and enzyme-linked immunosorbent assay of plasma antibodies. ( 25701023 )
2015
36
Shedding of Infectious Borna Disease Virus-1 in Living Bicolored White-Toothed Shrews. ( 26313904 )
2015
37
X-linked RNA-binding motif protein (RBMX) is required for the maintenance of Borna disease virus nuclear viral factories. ( 26333388 )
2015
38
A study on Borna disease virus infection in domestic cats in Japan. ( 24805904 )
2014
39
Inhibition of Borna disease virus replication by an endogenous bornavirus-like element in the ground squirrel genome. ( 25157155 )
2014
40
The bicolored white-toothed shrew Crocidura leucodon (HERMANN 1780) is an indigenous host of mammalian Borna disease virus. ( 24699636 )
2014
41
Human borna disease virus infection impacts host proteome and histone lysine acetylation in human oligodendroglia cells. ( 25086498 )
2014
42
Subcellular localization of Borna disease virus proteins, P and X, after heat stress. BDV-infected OL cells were incubated at 40A^C for 12 hr. The cells were stained with anti-P (red) and anti-X (green) antibodies and counterstained with DAPI (blue). ( 25363744 )
2014
43
Real-time qPCR identifies suitable reference genes for Borna disease virus-infected rat cortical neurons. ( 25431926 )
2014
44
Evidence for natural Borna disease virus infection in healthy domestic animals in three areas of western China. ( 24573218 )
2014
45
Proteomics reveal energy metabolism and mitogen-activated protein kinase signal transduction perturbation in human Borna disease virus Hu-H1-infected oligodendroglial cells. ( 24637096 )
2014
46
Borna disease virus (BDV) infection in psychiatric patients and healthy controls in Iran. ( 25186971 )
2014
47
Glutamate and lipid metabolic perturbation in the hippocampi of asymptomatic borna disease virus-infected horses. ( 24956478 )
2014
48
Borna disease virus infection in cats. ( 24480411 )
2014
49
Heat stress is a potent stimulus for enhancing rescue efficiency of recombinant Borna disease virus. ( 25154584 )
2014
50
Human but Not Laboratory Borna Disease Virus Inhibits Proliferation and Induces Apoptosis in Human Oligodendrocytes In Vitro. ( 23805250 )
2013

Variations for Borna Disease

Expression for Borna Disease

Search GEO for disease gene expression data for Borna Disease.

Pathways for Borna Disease

Pathways related to Borna Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.24 HSPA5 NCOA2

GO Terms for Borna Disease

Molecular functions related to Borna Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 8.8 HSPA5 MAP2K7 SORT1

Sources for Borna Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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