MCID: BTR001
MIFTS: 35

Botryoid Rhabdomyosarcoma

Categories: Cancer diseases, Fetal diseases, Muscle diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Botryoid Rhabdomyosarcoma

MalaCards integrated aliases for Botryoid Rhabdomyosarcoma:

Name: Botryoid Rhabdomyosarcoma 12 15 73
Sarcoma Botryoides 12 53
Botryoid Sarcoma 12 73
Botryoid-Type Embryonal Rhabdomyosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3255
NCIt 50 C9150
SNOMED-CT 68 14269005

Summaries for Botryoid Rhabdomyosarcoma

MalaCards based summary : Botryoid Rhabdomyosarcoma, also known as sarcoma botryoides, is related to embryonal rhabdomyosarcoma and rhabdomyosarcoma 2. An important gene associated with Botryoid Rhabdomyosarcoma is MYOD1 (Myogenic Differentiation 1), and among its related pathways/superpathways are Striated Muscle Contraction and Regulation of retinoblastoma protein. Affiliated tissues include cervix, uterus and prostate, and related phenotypes are cardiovascular system and homeostasis/metabolism

Wikipedia : 76 Sarcoma botryoides or botryoid sarcoma or botryoid rhabdomyosarcoma is a subtype of embryonal... more...

Related Diseases for Botryoid Rhabdomyosarcoma

Diseases in the Botryoid Rhabdomyosarcoma family:

Adult Botryoid Rhabdomyosarcoma

Diseases related to Botryoid Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 embryonal rhabdomyosarcoma 32.5 DES MB MYOD1 PAX3
2 rhabdomyosarcoma 2 31.5 DES MB MYOD1 PAX3
3 rhabdomyosarcoma 30.4 ACTC1 DES MB MYOD1 PAX3
4 gallbladder sarcoma 30.3 DES MYOD1
5 muscle cancer 29.6 DES MB MYOD1 PAX3
6 vulvar childhood botryoid-type embryonal rhabdomyosarcoma 12.5
7 childhood botryoid rhabdomyosarcoma 12.5
8 childhood vagina botryoid rhabdomyosarcoma 12.5
9 vagina botryoid rhabdomyosarcoma 12.5
10 adult botryoid rhabdomyosarcoma 12.5
11 adult vagina botryoid rhabdomyosarcoma 12.5
12 rhabdomyosarcoma, embryonal, 2 11.3
13 rhabdomyosarcoma, embryonal, 1 11.3
14 sarcoma 10.4
15 leydig cell tumor 10.2
16 sertoli-leydig cell tumor 10.2
17 bile duct cysts 10.1
18 wilms tumor 6 10.1
19 gallbladder rhabdomyosarcoma 10.1
20 ewing's family of tumors 10.1
21 inflammatory leiomyosarcoma 10.1 DES MYOD1
22 malignant fibrous histiocytoma of bone 10.1 DES MYOD1
23 horner's syndrome 10.1 DES MYOD1
24 central nervous system mesenchymal non-meningothelial tumor 10.1 MYOD1 PAX3
25 liposarcoma 10.1 DES MB
26 myofibroma 10.1 DES MB
27 giant cell myocarditis 10.1 DES MB
28 embryonal sarcoma 10.1 DES MYOD1
29 bilateral retinoblastoma 10.0 DES MB
30 breast rhabdomyosarcoma 10.0 MB MYOD1
31 adenosarcoma 10.0 DES MB
32 histiocytoma 10.0 MB MYOD1
33 retinoblastoma 10.0
34 dandy-walker syndrome 10.0
35 holoprosencephaly 1 10.0
36 cervical polyp 10.0
37 microcephaly 10.0
38 bladder sarcoma 10.0
39 vagina sarcoma 10.0
40 adenocarcinoma 10.0
41 adult fibrosarcoma 10.0 MB MYOD1
42 rhabdoid cancer 10.0 MB MYOD1
43 uterine sarcoma 10.0 DES MB
44 gas gangrene 10.0 MB MYOD1
45 fibromatosis 10.0 ACTC1 DES
46 ovarian fibrothecoma 10.0 ACTC1 DES
47 fibroblastic rheumatism 10.0 ACTC1 DES
48 angiolipoma 10.0 ACTC1 DES
49 cutaneous leiomyosarcoma 10.0 ACTC1 DES
50 spindle cell lipoma 10.0 ACTC1 DES

Graphical network of the top 20 diseases related to Botryoid Rhabdomyosarcoma:



Diseases related to Botryoid Rhabdomyosarcoma

Symptoms & Phenotypes for Botryoid Rhabdomyosarcoma

MGI Mouse Phenotypes related to Botryoid Rhabdomyosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 ACTC1 DES MB MYOD1 PAX3
2 homeostasis/metabolism MP:0005376 9.55 ACTC1 DES MB MYOD1 PAX3
3 mortality/aging MP:0010768 9.35 ACTC1 DES MB MYOD1 PAX3
4 muscle MP:0005369 9.02 ACTC1 DES MB MYOD1 PAX3

Drugs & Therapeutics for Botryoid Rhabdomyosarcoma

Search Clinical Trials , NIH Clinical Center for Botryoid Rhabdomyosarcoma

Genetic Tests for Botryoid Rhabdomyosarcoma

Anatomical Context for Botryoid Rhabdomyosarcoma

MalaCards organs/tissues related to Botryoid Rhabdomyosarcoma:

41
Cervix, Uterus, Prostate, Bone, Breast, Smooth Muscle, Skeletal Muscle

Publications for Botryoid Rhabdomyosarcoma

Articles related to Botryoid Rhabdomyosarcoma:

(show top 50) (show all 140)
# Title Authors Year
1
Botryoid Rhabdomyosarcoma of the Conjunctiva in a Young Boy. ( 30122858 )
2018
2
Local control for vaginal botryoid rhabdomyosarcoma with prerectal transperineal surgical resection and autologous buccal graft vaginal replacement: A novel, minimally invasive, radiation-sparing approach. ( 29258699 )
2017
3
Chemotherapy-induced differentiation to cure botryoid rhabdomyosarcoma: a case report and review of the literature. ( 29953806 )
2017
4
Botryoid Rhabdomyosarcoma of the Cervix: Case report with review of the literature. ( 26357564 )
2015
5
A successful pregnancy during the treatment of cervical sarcoma botryoides and advantage of fertility sparing management: A case report. ( 26000001 )
2015
6
Application of Creatsas vaginoplasty after radical surgical treatment of sarcoma botryoides. ( 24841520 )
2014
7
Sarcoma botryoides in an infant. ( 25519859 )
2014
8
A botryoid rhabdomyosarcoma diagnosed as a choledochal cyst. ( 23832499 )
2013
9
Massive diffuse intraperitoneal multicystic mass in an infant. Botryoid rhabdomyosarcoma (RMS). ( 22421724 )
2012
10
Botryoid rhabdomyosarcoma of the uterine cervix. ( 22943732 )
2012
11
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. ( 21847587 )
2012
12
Polypectomy followed by adjuvant chemotherapy in a patient with sarcoma botryoides of the uterine cervix--case report and review of the literature. ( 22384620 )
2011
13
Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma. ( 19194282 )
2009
14
Urinary bladder botryoid rhabdomyosarcoma with widespread metastases in an 8-month-old Labrador cross dog. ( 20169756 )
2009
15
Sarcoma botryoides: MRI findings in two patients. ( 19243064 )
2009
16
Case report of a sarcoma botryoides of the uterine cervix in fertile age and literature review. ( 19294398 )
2009
17
Cementless bilateral total hip arthroplasty in a patient with a history of pelvic irradiation for sarcoma botryoides. ( 19648766 )
2009
18
Primary renal botryoid rhabdomyosarcoma: diagnosis and outcome. ( 18082685 )
2007
19
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. ( 17630111 )
2007
20
Botryoid rhabdomyosarcoma of the biliary tract in children: a unique case report. ( 17177904 )
2006
21
Myogenic markers in the evaluation of embryonal botryoid rhabdomyosarcoma of the female genital tract. ( 16010486 )
2005
22
Myogenic markers in the evaluation of embryonal botryoid rhabdomyosarcoma of the female genital tract. ( 16220232 )
2005
23
Botryoid rhabdomyosarcoma of vagina--two case reports. ( 15887839 )
2004
24
Botryoid rhabdomyosarcoma of common bile duct. ( 15107524 )
2004
25
Management of stage I cervical sarcoma botryoides in childhood and adolescence. ( 15173941 )
2004
26
Botryoid rhabdomyosarcoma of mesentery--a case report. ( 15025305 )
2003
27
Urinary Bladder Botryoid Rhabdomyosarcoma with Immature Cartilage in a 24-year-old Male Patient: A Case Report. ( 17657126 )
2003
28
Relapse eighteen and one-half years after apparent cure of sarcoma botryoides of the vagina. ( 12825233 )
2003
29
[Embryonal botryoid rhabdomyosarcoma of the bladder]. ( 12410104 )
2002
30
Botryoid rhabdomyosarcoma of the bladder in an adult female. ( 17955586 )
2002
31
Botryoid rhabdomyosarcoma of the nose: pitfalls of pathology. ( 11359096 )
2001
32
Botryoid rhabdomyosarcoma of prostate--a case report. ( 12562002 )
2001
33
Isochromosome (17)(q10) as the sole structural chromosomal rearrangement in a case of botryoid rhabdomyosarcoma. ( 11454423 )
2001
34
Cytogenetic abnormalities in a case of botryoid rhabdomyosarcoma. ( 10742076 )
2000
35
Cervical sarcoma botryoides treated with conservative surgery and adjuvant chemotherapy: a case report. ( 11198042 )
2000
36
Sarcoma botryoides of the uterine cervix in a young woman: a case report. ( 11198044 )
2000
37
Cervical sarcoma botryoides. A case report. ( 10202753 )
1999
38
Sarcoma botryoides of the female genital tract: long-term results of conservative treatment followed by pregnancy. A case report. ( 10376429 )
1999
39
Conservative treatment followed by chemotherapy with doxorubicin and ifosfamide for cervical sarcoma botryoides in young females. ( 10408845 )
1999
40
Sarcoma botryoides in a seven year old: successful chemotherapeutic management. ( 15512240 )
1999
41
Urinary bladder rhabdomyosarcoma (sarcoma botryoides) in a young Newfoundland dog. ( 9637297 )
1998
42
Sarcoma botryoides of the uterine cervix: a case report. ( 9714990 )
1998
43
Botryoid rhabdomyosarcoma of the bladder. ( 9338741 )
1997
44
Sarcoma botryoides of the uterine endocervix: long-term results of conservative surgery. ( 8933824 )
1996
45
Sarcoma botryoides of the cervix treated with limited surgery and chemotherapy to preserve fertility. ( 7622119 )
1995
46
Sarcoma botryoides in CT imaging. Case report. ( 8547625 )
1995
47
Unique dermal and subcutaneous botryoid rhabdomyosarcoma associated with mature renal tissue: is this an extrarenal Wilms' tumor? ( 7971581 )
1994
48
Cytogenetic study of botryoid rhabdomyosarcoma of the uterine cervix. ( 8438559 )
1993
49
Botryoid rhabdomyosarcoma of the urinary bladder in a filly. ( 8373864 )
1993
50
Sarcoma botryoides of the vagina. ( 8501314 )
1993

Variations for Botryoid Rhabdomyosarcoma

Cosmic variations for Botryoid Rhabdomyosarcoma:

9 (show all 16)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10654 TP53 soft tissue,vagina,rhabdomyosarcoma,embryonal c.637C>T p.R213* 17:7674894-7674894 7
2 COSM44720 TP53 soft tissue,vagina,rhabdomyosarcoma,embryonal c.961A>T p.K321* 17:7673567-7673567 7
3 COSM13016 PTPN11 soft tissue,bladder,rhabdomyosarcoma,embryonal c.226G>C p.E76Q 12:112450406-112450406 7
4 COSM580 NRAS soft tissue,vagina,rhabdomyosarcoma,embryonal c.181C>A p.Q61K 1:114713909-114713909 7
5 COSM532 KRAS soft tissue,bladder,rhabdomyosarcoma,embryonal c.38G>A p.G13D 12:25245347-25245347 7
6 COSM6930430 KMT2D soft tissue,vagina,rhabdomyosarcoma,embryonal c.1291G>T p.E431* 12:49052392-49052392 7
7 COSM99615 soft tissue,vagina,rhabdomyosarcoma,embryonal c.637C>T p.R213* 17:7674894-7674894 7
8 COSM3378350 soft tissue,vagina,rhabdomyosarcoma,embryonal c.637C>T p.R213* 17:7674894-7674894 7
9 COSM6930429 soft tissue,vagina,rhabdomyosarcoma,embryonal c.1291G>T p.E431* 12:49052392-49052392 7
10 COSM99616 soft tissue,vagina,rhabdomyosarcoma,embryonal c.241C>T p.R81* 17:7674894-7674894 7
11 COSM3732985 soft tissue,vagina,rhabdomyosarcoma,embryonal c.961A>T p.K321* 17:7673567-7673567 7
12 COSM99618 soft tissue,vagina,rhabdomyosarcoma,embryonal c.637C>T p.R213* 17:7674894-7674894 7
13 COSM3732987 soft tissue,vagina,rhabdomyosarcoma,embryonal c.961A>T p.K321* 17:7673567-7673567 7
14 COSM3732986 soft tissue,vagina,rhabdomyosarcoma,embryonal c.961A>T p.K321* 17:7673567-7673567 7
15 COSM99617 soft tissue,vagina,rhabdomyosarcoma,embryonal c.358C>T p.R120* 17:7674894-7674894 7
16 COSM1638393 soft tissue,vagina,rhabdomyosarcoma,embryonal c.637C>T p.R213* 17:7674894-7674894 7

Expression for Botryoid Rhabdomyosarcoma

Search GEO for disease gene expression data for Botryoid Rhabdomyosarcoma.

Pathways for Botryoid Rhabdomyosarcoma

Pathways related to Botryoid Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.81 ACTC1 DES
2 10.37 MYOD1 PAX3

GO Terms for Botryoid Rhabdomyosarcoma

Biological processes related to Botryoid Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle organ development GO:0007517 8.96 MYOD1 PAX3
2 muscle filament sliding GO:0030049 8.62 ACTC1 DES

Sources for Botryoid Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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