MCID: BTR001
MIFTS: 35

Botryoid Rhabdomyosarcoma

Categories: Cancer diseases, Fetal diseases, Muscle diseases, Nephrological diseases, Rare diseases

Aliases & Classifications for Botryoid Rhabdomyosarcoma

MalaCards integrated aliases for Botryoid Rhabdomyosarcoma:

Name: Botryoid Rhabdomyosarcoma 12 15 71
Sarcoma Botryoides 12 52
Botryoid Sarcoma 12 71
Botryoid-Type Embryonal Rhabdomyosarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3255
NCIt 49 C9150
SNOMED-CT 67 405943005
UMLS 71 C1306573 C1306574

Summaries for Botryoid Rhabdomyosarcoma

MalaCards based summary : Botryoid Rhabdomyosarcoma, also known as sarcoma botryoides, is related to rhabdomyosarcoma 2 and cervical polyp. An important gene associated with Botryoid Rhabdomyosarcoma is MYOG (Myogenin), and among its related pathways/superpathways are Myogenesis and Mesenchymal Stem Cells and Lineage-specific Markers. Affiliated tissues include cervix, uterus and prostate, and related phenotypes are Decreased HPV16-GFP infection and homeostasis/metabolism

Wikipedia : 74 Sarcoma botryoides or botryoid sarcoma is a subtype of embryonal rhabdomyosarcoma, that can be observed... more...

Related Diseases for Botryoid Rhabdomyosarcoma

Diseases in the Botryoid Rhabdomyosarcoma family:

Adult Botryoid Rhabdomyosarcoma

Diseases related to Botryoid Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 rhabdomyosarcoma 2 31.3 PAX3 MYOG MYOD1 MB DES
2 cervical polyp 31.0 MYOG DES
3 undifferentiated embryonal sarcoma of the liver 30.8 MYOG MYOD1
4 fibroma 30.6 DES ACTC1
5 prostate rhabdomyosarcoma 30.5 MYOG MYOD1
6 spindle cell sarcoma 30.4 MYOG DES ACTC1
7 rare tumor 30.3 DES ACTC1
8 reticulum cell sarcoma 30.3 DES ACTC1
9 embryonal rhabdomyosarcoma 30.2 PAX3 MYOG MYOD1 MB DICER1 DES
10 gallbladder sarcoma 30.2 MYOG MYOD1 DES
11 embryonal sarcoma 30.2 MYOG MYOD1 DES
12 spindle cell carcinoma 30.1 DES ACTC1
13 sertoli-leydig cell tumor 30.0 DICER1 AFP
14 fibrous histiocytoma 30.0 MYOG DES ACTC1
15 malignant mesenchymoma 29.9 MYOG MYOD1 MB DES
16 carcinosarcoma 29.9 MB DES ACTC1
17 nephroma 29.7 DICER1 DES ACTC1
18 leiomyosarcoma 29.5 MYOG MB DES ACTC1
19 sarcoma 29.4 MYOG MYOD1 DICER1 DES ACTC1
20 malignant fibrous histiocytoma 29.1 MYOG MYOD1 MB DES ACTC1
21 wilms tumor 1 28.9 PAX3 MYOG DICER1 AFP
22 rhabdomyosarcoma 28.8 PAX3 MYOG MYOD1 MB DICER1 DES
23 muscle cancer 28.7 PAX3 MYOG MYOD1 MB DES
24 pleomorphic rhabdomyosarcoma 28.6 PAX3 MYOG MYOD1 MB ACTC1
25 adult botryoid rhabdomyosarcoma 12.8
26 vulvar childhood botryoid-type embryonal rhabdomyosarcoma 12.7
27 childhood botryoid rhabdomyosarcoma 12.7
28 childhood vagina botryoid rhabdomyosarcoma 12.7
29 vagina botryoid rhabdomyosarcoma 12.7
30 adult vagina botryoid rhabdomyosarcoma 12.7
31 rhabdomyosarcoma, embryonal, 2 11.5
32 rhabdomyosarcoma, embryonal, 1 11.5
33 sarcoma of cervix uteri 10.5
34 obstructive jaundice 10.4
35 malignant fibrous histiocytoma of bone 10.3 MYOD1 DES
36 bladder sarcoma 10.3
37 vagina sarcoma 10.3
38 inflammatory leiomyosarcoma 10.3 MYOG DES
39 liver rhabdomyosarcoma 10.3
40 bile duct cysts 10.3
41 hydronephrosis 10.3
42 rhabdomyosarcoma of the cervix uteri 10.3
43 conventional leiomyosarcoma 10.2 MYOG MYOD1
44 prostate embryonal rhabdomyosarcoma 10.2 MYOG MYOD1
45 giant cell myocarditis 10.2 MB DES
46 adult fibrosarcoma 10.2 MYOG MYOD1
47 prostate sarcoma 10.2 MYOG MYOD1
48 fibromatosis 10.2 DES ACTC1
49 fibroblastic rheumatism 10.2 DES ACTC1
50 ovarian fibrothecoma 10.2 DES ACTC1

Graphical network of the top 20 diseases related to Botryoid Rhabdomyosarcoma:



Diseases related to Botryoid Rhabdomyosarcoma

Symptoms & Phenotypes for Botryoid Rhabdomyosarcoma

GenomeRNAi Phenotypes related to Botryoid Rhabdomyosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased HPV16-GFP infection GR00350-A 8.62 AFP DES

MGI Mouse Phenotypes related to Botryoid Rhabdomyosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 ACTC1 AFP DES DICER1 MB MYOD1
2 mortality/aging MP:0010768 9.92 ACTC1 AFP DES DICER1 MB MYOD1
3 cardiovascular system MP:0005385 9.88 ACTC1 DES DICER1 MB MYOD1 PAX3
4 muscle MP:0005369 9.8 ACTC1 DES DICER1 MB MYOD1 MYOG
5 neoplasm MP:0002006 9.46 AFP DICER1 MYOD1 PAX3
6 normal MP:0002873 9.35 ACTC1 DICER1 MYOD1 MYOG PAX3
7 respiratory system MP:0005388 9.02 DICER1 MB MYOD1 MYOG PAX3

Drugs & Therapeutics for Botryoid Rhabdomyosarcoma

Search Clinical Trials , NIH Clinical Center for Botryoid Rhabdomyosarcoma

Genetic Tests for Botryoid Rhabdomyosarcoma

Anatomical Context for Botryoid Rhabdomyosarcoma

MalaCards organs/tissues related to Botryoid Rhabdomyosarcoma:

40
Cervix, Uterus, Prostate, Pancreas

Publications for Botryoid Rhabdomyosarcoma

Articles related to Botryoid Rhabdomyosarcoma:

(show top 50) (show all 285)
# Title Authors PMID Year
1
Recurrent Cervical Sarcoma Botryoides in a 3-Year-Old Female: Approach in a Limited Resource Setting. 61
31197128 2019
2
Botryoid Rhabdomyosarcoma of the Conjunctiva in a Young Boy. 61
31114128 2019
3
Prepubertal Genital Bleeding: Examination and Differential Diagnosis in Pediatric Female Patients. 61
30170834 2018
4
Local control for vaginal botryoid rhabdomyosarcoma with pre-rectal transperineal surgical resection and autologous buccal graft vaginal replacement: A novel, minimally invasive, radiation-sparing approach. 61
29258699 2018
5
Foley Catheter as a Vaginal Stent in a Toddler with Vaginal Rhabdomyosarcoma. 61
29233732 2018
6
Botryoid Rhabdomyosarcoma of the Conjunctiva in a Young Boy. 61
30122858 2018
7
Management of Low-Grade Cervical Müllerian Adenosarcoma in a 14-Year-Old Girl. 61
28578185 2017
8
Conservative management of primary vaginal endodermal sinus tumor and rhabdomyosarcoma. 61
28969004 2017
9
Pediatric Gynecologic Cancers. 61
28501984 2017
10
Phacomatosis Pigmentokeratotica: A Mosaic RASopathy with Malignant Potential. 61
28523882 2017
11
Multimodality imaging of vaginal rhabdomyosarcoma. 61
28744074 2017
12
Vaginectomy and Buccal Mucosa Vaginoplasty as Local Therapy for Pediatric Vaginal Rhabdomyosarcoma. 61
28232175 2017
13
Chemotherapy-induced differentiation to cure botryoid rhabdomyosarcoma: a case report and review of the literature. 61
29953806 2017
14
Botryoid Rhabdomyosarcoma of the Cervix: Case report with review of the literature. 61
26357564 2015
15
A successful pregnancy during the treatment of cervical sarcoma botryoides and advantage of fertility sparing management: A case report. 61
26000001 2015
16
Sarcoma botryoides in an infant. 61
25519859 2014
17
Application of Creatsas vaginoplasty after radical surgical treatment of sarcoma botryoides. 61
24841520 2014
18
A botryoid rhabdomyosarcoma diagnosed as a choledochal cyst. 61
23832499 2013
19
Myogenin expression in vulvovaginal spindle cell lesions: analysis of a series of cases with an emphasis on diagnostic pitfalls. 61
23944986 2013
20
Vulvar embryonal rhabdomyosarcoma: a case report. 61
23602842 2013
21
Botryoid rhabdomyosarcoma of the uterine cervix. 61
22943732 2012
22
Embryonal (botryoides) rhabdomyosarcoma of the uterus harboring a primitive neuroectodermal tumor component. 61
22653355 2012
23
Embryonal rhabdomyosarcoma of the caruncle in a 4 year-old boy: case report. 61
22872206 2012
24
Embryonal rhabdomyosarcoma of the uterine cervix: a report of 14 cases and a discussion of its unusual clinicopathological associations. 61
22157934 2012
25
Cervical sarcoma botryoides and ovarian Sertoli-Leydig cell tumor: a case report and review of literature. 61
21847587 2012
26
Massive diffuse intraperitoneal multicystic mass in an infant. Botryoid rhabdomyosarcoma (RMS). 61
22421724 2012
27
Polypectomy followed by adjuvant chemotherapy in a patient with sarcoma botryoides of the uterine cervix--case report and review of the literature. 61
22384620 2011
28
Primary "botryoid" embryonal rhabdomyosarcoma in mesentery. 61
21469433 2011
29
Sarcoma botryoides (embryonal rhabdomyosarcoma) of the uterine cervix in sisters. 61
21278891 2010
30
[Botryoid Wilms tumor extending into the duodenum]. 61
20943355 2010
31
[Sarcoma botryoides of the uterine cervix]. 61
21049428 2010
32
Extrarenal teratoid Wilms' tumor: two cases in unusual locations, one associated with elevated serum AFP. 61
20055950 2010
33
Trisomy 8 as a sole aberration in embryonal rhabdomyosarcoma (sarcoma botryoides) of the vagina. 61
19963119 2009
34
Mixed Müllerian Tumors of the Female Genital Tract. 61
26838776 2009
35
Case report of a sarcoma botryoides of the uterine cervix in fertile age and literature review. 61
19294398 2009
36
Mixed embryonal/alveolar rhabdomyosarcoma of the prostate: report of a case with molecular genetic studies and literature review. 61
19175284 2009
37
Urinary bladder botryoid rhabdomyosarcoma with widespread metastases in an 8-month-old Labrador cross dog. 61
20169756 2009
38
Endodermal sinus tumor of the vagina in children: a report of two cases. 61
19679975 2009
39
Primary gallbladder sarcoma: a clinicopathologic study of 15 cases, heterogeneous sarcomas with poor outcome, except pediatric botryoid rhabdomyosarcoma. 61
19194282 2009
40
Sarcoma botryoides: MRI findings in two patients. 61
19243064 2009
41
Cementless bilateral total hip arthroplasty in a patient with a history of pelvic irradiation for sarcoma botryoides. 61
19648766 2009
42
[Cholestasis caused by a choledochal botryoid rhabdomyosarcoma in a 22-month-old boy]. 61
18538715 2008
43
Embryonal rhabdomyosarcoma arising in the ureter. 61
18568985 2008
44
Multimodal therapy for the initial management of genital embryonal rhabdomyosarcoma in childhood. 61
17511807 2008
45
Primary renal botryoid rhabdomyosarcoma: diagnosis and outcome. 61
18082685 2007
46
Cytologic features of müllerian papilloma of the cervix: mimic of malignancy. 61
17703455 2007
47
Right atrial botryoid rhabdomyosarcoma in an adult patient with recurrent pleomorphic rhabdomyosarcomas following doxorubicin therapy. 61
17630111 2007
48
Expression of erbB-1 and erbB-2 genes in normal and pathological human endometrium. 61
17549377 2007
49
[Rhabdomyosarcoma in the urogenital region of a child]. 61
17311757 2007
50
Embryonal rhabdomyosarcoma of the cervix with focal pleomorphic areas. 61
17213352 2007

Variations for Botryoid Rhabdomyosarcoma

Cosmic variations for Botryoid Rhabdomyosarcoma:

9
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM112255322 soft tissue,vagina,rhabdomyosarcoma,embryonal c.637C>T p.R213* 17:7674894-7674894 0

Expression for Botryoid Rhabdomyosarcoma

Search GEO for disease gene expression data for Botryoid Rhabdomyosarcoma.

Pathways for Botryoid Rhabdomyosarcoma

Pathways related to Botryoid Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.92 MYOG MYOD1
2 10.9 PAX3 MYOG MYOD1 DES
3 10.7 PAX3 MYOD1

GO Terms for Botryoid Rhabdomyosarcoma

Biological processes related to Botryoid Rhabdomyosarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 skeletal muscle tissue development GO:0007519 9.52 MYOG MYOD1
2 skeletal muscle cell differentiation GO:0035914 9.51 MYOG MYOD1
3 muscle filament sliding GO:0030049 9.49 DES ACTC1
4 cellular response to estradiol stimulus GO:0071392 9.48 MYOG MYOD1
5 positive regulation of muscle cell differentiation GO:0051149 9.46 MYOG MYOD1
6 skeletal muscle fiber development GO:0048741 9.43 MYOG MYOD1
7 positive regulation of myoblast differentiation GO:0045663 9.4 MYOG MYOD1
8 positive regulation of myoblast fusion GO:1901741 9.37 MYOG MYOD1
9 muscle organ development GO:0007517 9.33 PAX3 MYOG MYOD1
10 myoblast differentiation GO:0045445 9.32 MYOG MYOD1
11 myotube differentiation GO:0014902 9.26 MYOG MYOD1
12 positive regulation of skeletal muscle fiber development GO:0048743 8.96 MYOG MYOD1
13 muscle cell fate commitment GO:0042693 8.62 MYOG MYOD1

Molecular functions related to Botryoid Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 E-box binding GO:0070888 8.62 MYOG MYOD1

Sources for Botryoid Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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