BNHS
MCID: BCH003
MIFTS: 40
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Boucher-Neuhauser Syndrome (BNHS)
Categories:
Endocrine diseases, Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases, Reproductive diseases
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MalaCards integrated aliases for Boucher-Neuhauser Syndrome:
Characteristics:Orphanet epidemiological data:58
ataxia-hypogonadism-choroidal dystrophy syndrome
Inheritance: Autosomal recessive; Age of onset: Childhood; OMIM:56
Inheritance:
autosomal recessive
Miscellaneous:
progressive disorder some features are variable, even within families neurologic signs onset during adolescence or young adulthood ophthalmologic signs onset in first to sixth decade some patients become wheelchair-bound HPO:31
boucher-neuhauser syndrome:
Inheritance autosomal recessive inheritance Onset and clinical course juvenile onset progressive Classifications:
MalaCards categories:
Global: Genetic diseases Rare diseases Anatomical: Neuronal diseases Eye diseases Reproductive diseases Endocrine diseases
ICD10:
33
Orphanet: 58
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Genetics Home Reference :
25
Boucher-Neuhäuser syndrome is a rare disorder that affects movement, vision, and sexual development. It is part of a continuous spectrum of neurological conditions, known as PNPLA6-related disorders, that share a genetic cause and have a combination of overlapping features. Boucher-Neuhäuser syndrome is characterized by three specific features: ataxia, hypogonadotropic hypogonadism, and chorioretinal dystrophy.
PNPLA6
Ataxia describes difficulty with coordination and balance. In Boucher-Neuhäuser syndrome, it arises from a loss of cells (atrophy) in the part of the brain involved in coordinating movements (the cerebellum). Affected individuals have an unsteady walking style (gait) and frequent falls.
Another key feature of Boucher-Neuhäuser syndrome is hypogonadotropic hypogonadism, which is a condition affecting the production of hormones that direct sexual development. Affected individuals have a delay in development of the typical signs of puberty, such as the growth of facial hair and deepening of the voice in males, and the start of monthly periods (menstruation) and breast development in females. Other hormone abnormalities lead to short stature in some affected individuals.
The third characteristic feature of Boucher-Neuhäuser syndrome is eye abnormalities, most commonly chorioretinal dystrophy. Chorioretinal dystrophy refers to problems with the light-sensitive tissue that lines the back of the eye (the retina) and a nearby tissue layer called the choroid. These eye abnormalities lead to impaired vision. People with Boucher-Neuhäuser syndrome can also have abnormal eye movements, including involuntary side-to-side movements of the eyes (nystagmus).
The key features of Boucher-Neuhäuser syndrome can begin anytime from infancy to adulthood, although at least one feature usually occurs by adolescence. Ataxia is often the initial symptom of the disorder, but vision problems or delayed puberty can be the earliest finding. Vision and movement problems worsen slowly throughout life and can result in blindness or the need for a wheelchair for mobility in the most severely affected individuals.
People with Boucher-Neuhäuser syndrome can have additional medical problems, including muscle stiffness (spasticity); impaired speech (dysarthria); and difficulty processing, learning, or remembering information (cognitive impairment).
MalaCards based summary : Boucher-Neuhauser Syndrome, also known as ataxia-hypogonadism-choroidal dystrophy syndrome, is related to gordon holmes syndrome and pnpla6-related disorders, and has symptoms including scanning speech, action tremor and cerebellar ataxia. An important gene associated with Boucher-Neuhauser Syndrome is PNPLA6 (Patatin Like Phospholipase Domain Containing 6), and among its related pathways/superpathways is Glycerophospholipid metabolism. Affiliated tissues include eye, cerebellum and brain, and related phenotypes are ataxia and chorioretinal dystrophy Disease Ontology : 12 A syndrome characterized by spinocerebellar ataxia, hypogonadotropic hypogonadism, and chorioretinal dystrophy that has material basis in homozygous or compound heterozygous mutation in PNPLA6 on 19p13.2. NIH Rare Diseases : 52 The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 1180 Definition A very rare autosomal recessive , slowly progressive neurodegenerative disorder characterized by the triad of cerebellar ataxia (that generally manifests at adolescence or early adulthood), chorioretinal dystrophy, which may have a later onset (up to the fifth-sixth decade) leading to variable degrees of visual impairment, and hypogonadotropic hypogonadism (delayed puberty and lack of secondary sex characteristics). Ataxia-hypogonadism-choroidal dystrophy syndrome belongs to a clinical continuum of neurodegenerative disorders along with the clinically overlapping cerebellar ataxia-hypogonadism syndrome (see this term). Visit the Orphanet disease page for more resources. OMIM : 56 Boucher-Neuhauser syndrome is an autosomal recessive disorder characterized classically by the triad of spinocerebellar ataxia, hypogonadotropic hypogonadism, and visual impairment due to chorioretinal dystrophy. The age at onset is variable, but most patients develop one or more symptoms in the first decade of life. Chorioretinal dystrophy may not always be present. BNHS is part of a spectrum of neurodegenerative diseases associated with mutations in the PNPLA6 gene that also includes spastic paraplegia-39 (SPG39; 612020) (summary by Synofzik et al., 2014). See also Gordon Holmes syndrome (GDHS; 212840), caused by mutation in the RNF216 gene (609948), which is also characterized by the combination of cerebellar ataxia and hypogonadotropic hypogonadism. (215470) KEGG : 36 Boucher-Neuhauser syndrome (BNS) is a rare syndrome characterized by the triad of early-onset autosomal-recessive cerebellar ataxia (ARCA), hypogonadotropic hypogonadism, and chorioretinal dystrophy. Gait ataxia in BNS has been typically reported between the first and third decades of life; later ages of onset are rare. BNS has recently been linked to autosomal-recessive mutations in the PNPLA6 gene. UniProtKB/Swiss-Prot : 73 Boucher-Neuhauser syndrome: An autosomal recessive disorder characterized by spinocerebellar ataxia, hypogonadotropic hypogonadism, and visual impairment due to chorioretinal dystrophy. The age at onset is variable, but most patients develop 1 or more symptoms in the first decade of life. Chorioretinal dystrophy may not always be present. |
Human phenotypes related to Boucher-Neuhauser Syndrome:58 31 (show all 20)
Symptoms via clinical synopsis from OMIM:56Clinical features from OMIM:215470UMLS symptoms related to Boucher-Neuhauser Syndrome:scanning speech, action tremor, cerebellar ataxia |
Cochrane evidence based reviews: chorioretinal dystrophy, spinocerebellar ataxia, and hypogonadotropic hypogonadism |
MalaCards organs/tissues related to Boucher-Neuhauser Syndrome:40
Eye,
Cerebellum,
Brain,
Retina,
Breast,
Pituitary,
Neutrophil
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Articles related to Boucher-Neuhauser Syndrome:(show all 19)
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ClinVar genetic disease variations for Boucher-Neuhauser Syndrome:6
UniProtKB/Swiss-Prot genetic disease variations for Boucher-Neuhauser Syndrome:73
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Search
GEO
for disease gene expression data for Boucher-Neuhauser Syndrome.
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Pathways related to Boucher-Neuhauser Syndrome according to KEGG:36
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Cellular components related to Boucher-Neuhauser Syndrome according to GeneCards Suite gene sharing:
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