MCID: BTN002
MIFTS: 44

Boutonneuse Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Boutonneuse Fever

MalaCards integrated aliases for Boutonneuse Fever:

Name: Boutonneuse Fever 12 60 45 15 17 74
Mediterranean Spotted Fever 12 60 56
African Tick Typhus 12 60
Rickettsia Conorii Spotted Fever 12
South African Tick-Bite Fever 12
Conor and Bruch's Disease 12
Mediterranean Tick Fever 12
African Tick Bite Fever 74
Boutonneuse Disease 12
Kenyan Tick Typhus 12
Kenya Tick Typhus 12
Marseilles Fever 12
Kenya Fever 12

Characteristics:

Orphanet epidemiological data:

60
boutonneuse fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
african tick typhus
Inheritance: Not applicable;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14095
ICD9CM 36 082.1
MeSH 45 D001907
SNOMED-CT 69 59742009
ICD10 34 A77.1
MESH via Orphanet 46 D001907
ICD10 via Orphanet 35 A77.1
UMLS via Orphanet 75 C0006060

Summaries for Boutonneuse Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary : Boutonneuse Fever, also known as mediterranean spotted fever, is related to spotted fever and vasculitis, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is SELE (Selectin E), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Affiliated tissues include skin, testes and endothelial, and related phenotypes are cardiovascular system and cellular

Wikipedia : 77 Boutonneuse fever (also called Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus,... more...

Related Diseases for Boutonneuse Fever

Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 spotted fever 30.5 AFF2 THBD
2 vasculitis 29.5 SELE SELL SERPINA1 THBD
3 african tick-bite fever 12.1
4 arthritis 10.3
5 fascioliasis 10.3 CP SELE
6 rocky mountain spotted fever 10.3
7 chronic pyelonephritis 10.2 CP TLR4
8 encephalitis 10.2
9 retinitis pigmentosa 60 10.2 SELE SELL
10 plummer's disease 10.2 SELE SELL
11 epidemic typhus 10.2
12 bacterial sepsis 10.2 SELE TLR4
13 leukostasis 10.2 SELE SELL
14 leukocyte adhesion deficiency, type i 10.2 SELE SELL
15 granulocytopenia 10.2 CP SELL
16 encephalopathy 10.2
17 polyarteritis nodosa 10.2 SELE SELL
18 subendocardial myocardial infarction 10.2 SELE SERPINA1
19 periodontosis 10.2 SELL TLR4
20 ancylostomiasis 10.2 CP SERPINA1
21 salmonellosis 10.2 CP TLR4
22 granulosa cell tumor of the ovary 10.1 CP SERPINA1
23 temporal arteritis 10.1
24 depression 10.1
25 variola major 10.1 IL2 TLR4
26 mental retardation, x-linked, associated with fragile site fraxe 10.1 AFF2 SERPINA1
27 pneumoconiosis 10.1 CP SERPINA1
28 endemic typhus 10.1
29 q fever 10.1
30 pancytopenia 10.1
31 pericarditis 10.1
32 toxicodendron dermatitis 10.1 IL2 SELL
33 fixed drug eruption 10.1 IL2 SELL
34 paracoccidioidomycosis 10.0 IL2 TLR4
35 phacolytic glaucoma 10.0 IL2 SERPINA1
36 brucellosis 10.0 IL2 TLR4
37 b-cell expansion with nfkb and t-cell anergy 10.0 IL2 SELL
38 filariasis 10.0 IL2 TLR4
39 pleurisy 10.0 IL2 SELL
40 proteasome-associated autoinflammatory syndrome 1 10.0 SELE SELL TLR4
41 grange syndrome 10.0 SELE THBD
42 primary bacterial infectious disease 10.0 IL2 TLR4
43 diabetic angiopathy 10.0 SELE THBD
44 visceral leishmaniasis 10.0 IL2 TLR4
45 thrombotic thrombocytopenic purpura 10.0 SELE THBD
46 toxic shock syndrome 9.9 IL2 TLR4
47 pfeiffer syndrome 9.9
48 mitochondrial import-stimulating factor 9.9
49 stroke, ischemic 9.9
50 kawasaki disease 9.9

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to Boutonneuse Fever

Symptoms & Phenotypes for Boutonneuse Fever

Symptoms:

12
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

MGI Mouse Phenotypes related to Boutonneuse Fever:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 CP IL2 SELE SELL THBD TLR4
2 cellular MP:0005384 9.8 CP IL2 SELE SELL THBD TLR4
3 hematopoietic system MP:0005397 9.73 CP IL2 SELE SELL THBD TLR4
4 immune system MP:0005387 9.63 CP IL2 SELE SELL THBD TLR4
5 liver/biliary system MP:0005370 9.43 CP IL2 SELE SELL THBD TLR4
6 respiratory system MP:0005388 9.02 IL2 SELE SELL THBD TLR4

Drugs & Therapeutics for Boutonneuse Fever

Search Clinical Trials , NIH Clinical Center for Boutonneuse Fever

Cochrane evidence based reviews: boutonneuse fever

Genetic Tests for Boutonneuse Fever

Anatomical Context for Boutonneuse Fever

MalaCards organs/tissues related to Boutonneuse Fever:

42
Skin, Testes, Endothelial, Kidney, Liver, Eye, T Cells

Publications for Boutonneuse Fever

Articles related to Boutonneuse Fever:

(show top 50) (show all 145)
# Title Authors Year
1
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. ( 30197269 )
2019
2
Clinically-diagnosed Mediterranean Spotted Fever in Malta. ( 29462726 )
2018
3
Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever. ( 30150470 )
2018
4
Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever. ( 30508810 )
2018
5
Mediterranean Spotted Fever: A Rare Non-Endemic Disease in the USA. ( 28191378 )
2017
6
Mediterranean spotted fever in Spain, 1997-2014: Epidemiological situation based on hospitalization records. ( 28355307 )
2017
7
Epidemiological evaluation of Mediterranean spotted fever in children of the Karak province in south Jordan. ( 28368858 )
2017
8
Myocarditis in Mediterranean spotted fever: a case report and a review of the literature. ( 28348768 )
2016
9
Shell-vial culture, coupled with real-time PCR, applied to Rickettsia conorii and Rickettsia massiliae-Bar29 detection, improving the diagnosis of the Mediterranean spotted fever. ( 26830273 )
2016
10
Randomized Trial of Clarithromycin for Mediterranean Spotted Fever. ( 26711765 )
2015
11
Boutonneuse fever and climate variability. ( 17114701 )
2006
12
Role of TLR4 receptor polymorphisms in Boutonneuse fever. ( 16388712 )
2005
13
Boutonneuse fever in a child: a case report and overview. ( 15473280 )
2004
14
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. ( 12800955 )
2003
15
Evaluation of clinical diagnosis scores for Boutonneuse fever. ( 12860646 )
2003
16
The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992-1997. ( 11243751 )
2001
17
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. ( 10886788 )
2000
18
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. ( 10444262 )
1999
19
Clinical and laboratory findings of boutonneuse fever in Sicilian children. ( 9667405 )
1998
20
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. ( 9528898 )
1998
21
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. ( 8985208 )
1997
22
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? ( 9334871 )
1997
23
Oculoglandular syndrome in Mediterranean spotted fever acquired through the eye. ( 9059259 )
1997
24
Mediterranean spotted fever mimicking Kawasaki disease. ( 9066481 )
1997
25
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. ( 8896508 )
1996
26
Isolation of Rickettsia akari from a patient in a region where Mediterranean spotted fever is endemic. ( 8838175 )
1996
27
Diagnosis of Mediterranean spotted fever by cultivation of Rickettsia conorii from blood and skin samples using the centrifugation-shell vial technique and by detection of R. conorii in circulating endothelial cells: a 6-year follow-up. ( 8897172 )
1996
28
Mediterranean spotted fever: a preliminary tick field study. ( 8905308 )
1996
29
Azithromycin vs. doxycycline for Mediterranean spotted fever. ( 8933556 )
1996
30
Mediterranean spotted fever and arthritis: comment on the article by Sundy et al. ( 8961921 )
1996
31
Release of soluble tumor necrosis factor receptors in Mediterranean spotted fever rickettsiosis. ( 8991643 )
1996
32
Immunoblot cross-reactions among Rickettsia, Proteus spp. and Legionella spp. in patients with Mediterranean spotted fever. ( 7541270 )
1995
33
Acute renal failure as a complication of Mediterranean spotted fever. ( 7753272 )
1995
34
Canine seroprevalence of Rickettsia conorii infection (Mediterranean spotted fever) in Castilla y León (northwest Spain). ( 8549737 )
1995
35
Antiphospholipid antibody production during Mediterranean spotted fever. ( 8679900 )
1995
36
High levels of interferon-gamma in boutonneuse fever. ( 7996014 )
1994
37
[Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. ( 8059165 )
1994
38
Plasma levels of tumor necrosis factor alpha in patients with Mediterranean spotted fever: clinical and analytical correlations. ( 7888547 )
1994
39
Western blot as a seroepidemiologic tool for detecting foci of Mediterranean spotted fever (MSF). ( 7957788 )
1994
40
Involvement of the kidneys in Mediterranean spotted fever and murine typhus. ( 8153286 )
1994
41
Enhanced thromboxane biosynthesis in patients with Mediterranean spotted fever. ( 8180409 )
1994
42
Mediterranean Spotted Fever in Central Tunisia. ( 9815320 )
1994
43
Arthritis in Mediterranean spotted fever. An immune complex mediated synovitis. ( 8339144 )
1993
44
Mediterranean spotted fever in Marseille, France: correlation between prevalence of hospitalized patients, seroepidemiology, and prevalence of infected ticks in three different areas. ( 8447529 )
1993
45
[Changes in plasma lipoproteins in Mediterranean boutonneuse fever]. ( 1347656 )
1992
46
Spotless boutonneuse fever. ( 1571413 )
1992
47
Spotless boutonneuse fever. ( 1520773 )
1992
48
Deleterious effect of trimethoprim-sulfamethoxazole in Mediterranean spotted fever. ( 1416836 )
1992
49
Thrombosis of the mesenteric vein as a complication of Mediterranean spotted fever. ( 1457656 )
1992
50
Use of western blot to analyze the reactivity of sera from patients with Mediterranean spotted fever. ( 1486892 )
1992

Variations for Boutonneuse Fever

Expression for Boutonneuse Fever

Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for Boutonneuse Fever

GO Terms for Boutonneuse Fever

Cellular components related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CP IL2 SELE SERPINA1 THBD

Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of inflammatory response GO:0050729 9.4 IL2 TLR4
2 regulation of inflammatory response GO:0050727 9.37 SELE TLR4
3 hemostasis GO:0007599 9.32 SERPINA1 THBD
4 positive regulation of interferon-gamma production GO:0032729 9.26 IL2 TLR4
5 positive regulation of B cell proliferation GO:0030890 9.16 IL2 TLR4
6 response to lipopolysaccharide GO:0032496 9.13 SELE THBD TLR4
7 leukocyte tethering or rolling GO:0050901 8.62 SELE SELL

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.43 SELE THBD TLR4
2 carbohydrate binding GO:0030246 9.33 IL2 SELE SELL
3 oligosaccharide binding GO:0070492 8.96 SELE SELL
4 glycosphingolipid binding GO:0043208 8.62 IL2 SELL

Sources for Boutonneuse Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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