MCID: BTN002
MIFTS: 44

Boutonneuse Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Boutonneuse Fever

MalaCards integrated aliases for Boutonneuse Fever:

Name: Boutonneuse Fever 12 59 44 15 73
Mediterranean Spotted Fever 12 59 55
African Tick Typhus 12 59
Rickettsia Conorii Spotted Fever 12
South African Tick-Bite Fever 12
Conor and Bruch's Disease 12
Mediterranean Tick Fever 12
African Tick Bite Fever 73
Boutonneuse Disease 12
Kenyan Tick Typhus 12
Kenya Tick Typhus 12
Marseilles Fever 12
Kenya Fever 12

Characteristics:

Orphanet epidemiological data:

59
boutonneuse fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
african tick typhus
Inheritance: Not applicable;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14095
ICD10 33 A77.1
ICD9CM 35 082.1
MeSH 44 D001907
SNOMED-CT 68 59742009
MESH via Orphanet 45 D001907
UMLS via Orphanet 74 C0006060
ICD10 via Orphanet 34 A77.1

Summaries for Boutonneuse Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary : Boutonneuse Fever, also known as mediterranean spotted fever, is related to spotted fever and vasculitis, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is SELE (Selectin E), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Affiliated tissues include skin, endothelial and liver, and related phenotypes are cardiovascular system and cellular

Wikipedia : 76 Boutonneuse fever (also called Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus,... more...

Related Diseases for Boutonneuse Fever

Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 spotted fever 30.6 AFF2 THBD
2 vasculitis 29.6 SELE SELL SERPINA1 THBD
3 african tick-bite fever 12.0
4 arthritis 10.3
5 rocky mountain spotted fever 10.3
6 encephalitis 10.2
7 encephalopathy 10.2
8 fascioliasis 10.2 CP SELE
9 chronic pyelonephritis 10.2 CP TLR4
10 bacterial sepsis 10.1 SELE TLR4
11 variola major 10.1 IL2 TLR4
12 subendocardial myocardial infarction 10.1 SELE SERPINA1
13 ancylostomiasis 10.1 CP SERPINA1
14 salmonellosis 10.1 CP TLR4
15 depression 10.1
16 paracoccidioidomycosis 10.1 IL2 TLR4
17 granulosa cell tumor of the ovary 10.1 CP SERPINA1
18 phacolytic glaucoma 10.1 IL2 SERPINA1
19 retinitis pigmentosa 60 10.1 SELE SELL
20 plummer's disease 10.1 SELE SELL
21 brucellosis 10.1 IL2 TLR4
22 endemic typhus 10.1
23 q fever 10.1
24 pancytopenia 10.1
25 pericarditis 10.1
26 leukostasis 10.1 SELE SELL
27 leukocyte adhesion deficiency, type i 10.1 SELE SELL
28 filariasis 10.1 IL2 TLR4
29 mental retardation, x-linked, associated with fragile site fraxe 10.1 AFF2 SERPINA1
30 granulocytopenia 10.1 CP SELL
31 polyarteritis nodosa 10.1 SELE SELL
32 pneumoconiosis 10.1 CP SERPINA1
33 primary bacterial infectious disease 10.1 IL2 TLR4
34 periodontosis 10.1 SELL TLR4
35 toxicodendron dermatitis 10.1 IL2 SELL
36 fixed drug eruption 10.1 IL2 SELL
37 visceral leishmaniasis 10.0 IL2 TLR4
38 toxic shock syndrome 10.0 IL2 TLR4
39 b-cell expansion with nfkb and t-cell anergy 10.0 IL2 SELL
40 pleurisy 10.0 IL2 SELL
41 grange syndrome 10.0 SELE THBD
42 diabetic angiopathy 10.0 SELE THBD
43 thrombotic thrombocytopenic purpura 10.0 SELE THBD
44 carotid artery disease 10.0 SELE THBD
45 proteasome-associated autoinflammatory syndrome 1 9.9 SELE SELL TLR4
46 polyposis, skin pigmentation, alopecia, and fingernail changes 9.9 SERPINA1 THBD
47 respiratory system disease 9.9 IL2 SERPINA1 TLR4
48 takayasu arteritis 9.9 SELE THBD
49 gastrointestinal system disease 9.9 IL2 SERPINA1 TLR4
50 chagas disease 9.9 IL2 TLR4

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to Boutonneuse Fever

Symptoms & Phenotypes for Boutonneuse Fever

Symptoms:

12
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

MGI Mouse Phenotypes related to Boutonneuse Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 CP IL2 SELE SELL THBD TLR4
2 cellular MP:0005384 9.8 CP IL2 SELE SELL THBD TLR4
3 hematopoietic system MP:0005397 9.73 CP IL2 SELE SELL THBD TLR4
4 immune system MP:0005387 9.63 CP IL2 SELE SELL THBD TLR4
5 liver/biliary system MP:0005370 9.43 CP IL2 SELE SELL THBD TLR4
6 respiratory system MP:0005388 9.02 IL2 SELE SELL THBD TLR4

Drugs & Therapeutics for Boutonneuse Fever

Search Clinical Trials , NIH Clinical Center for Boutonneuse Fever

Cochrane evidence based reviews: boutonneuse fever

Genetic Tests for Boutonneuse Fever

Anatomical Context for Boutonneuse Fever

MalaCards organs/tissues related to Boutonneuse Fever:

41
Skin, Endothelial, Liver, T Cells, Ovary, B Cells, Testes

Publications for Boutonneuse Fever

Articles related to Boutonneuse Fever:

(show top 50) (show all 151)
# Title Authors Year
1
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. ( 30197269 )
2019
2
Clinically-diagnosed Mediterranean Spotted Fever in Malta. ( 29462726 )
2018
3
Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever. ( 30150470 )
2018
4
Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever. ( 30508810 )
2018
5
Mediterranean Spotted Fever: A Rare Non-Endemic Disease in the USA. ( 28191378 )
2017
6
Mediterranean spotted fever in Spain, 1997-2014: Epidemiological situation based on hospitalization records. ( 28355307 )
2017
7
Epidemiological evaluation of Mediterranean spotted fever in children of the Karak province in south Jordan. ( 28368858 )
2017
8
Myocarditis in Mediterranean spotted fever: a case report and a review of the literature. ( 28348768 )
2016
9
Shell-vial culture, coupled with real-time PCR, applied to Rickettsia conorii and Rickettsia massiliae-Bar29 detection, improving the diagnosis of the Mediterranean spotted fever. ( 26830273 )
2016
10
Mediterranean spotted fever with lymphangitis occurring from a tick bite lesion. A case in Spain. ( 26173583 )
2015
11
Randomized Trial of Clarithromycin for Mediterranean Spotted Fever. ( 26711765 )
2015
12
Mediterranean spotted fever in southeastern Romania. ( 24024190 )
2013
13
Mediterranean spotted fever, a diagnostic challenge in travellers. ( 20101874 )
2009
14
Boutonneuse fever and climate variability. ( 17114701 )
2006
15
Mediterranean spotted fever: clinical and laboratory characteristics of 415 Sicilian children. ( 16553943 )
2006
16
Role of TLR4 receptor polymorphisms in Boutonneuse fever. ( 16388712 )
2005
17
Boutonneuse fever in a child: a case report and overview. ( 15473280 )
2004
18
Boutonneuse fever in Portugal: 1995-2000. Data of a state laboratory. ( 12800955 )
2003
19
Evaluation of clinical diagnosis scores for Boutonneuse fever. ( 12860646 )
2003
20
The acute phase response in Sicilian patients with boutonneuse fever admitted to hospitals in Palermo, 1992-1997. ( 11243751 )
2001
21
Interleukin-12 in human boutonneuse fever caused by Rickettsia conorii. ( 10886788 )
2000
22
Differential up-regulation of circulating soluble selectins and endothelial adhesion molecules in Sicilian patients with Boutonneuse fever. ( 10444262 )
1999
23
Mediterranean spotted fever in pregnancy. ( 10447334 )
1999
24
Clinical and laboratory findings of boutonneuse fever in Sicilian children. ( 9667405 )
1998
25
Modifications of general parameters of immune activation in the sera of Sicilian patients with Boutonneuse fever. ( 9528898 )
1998
26
Alteration of interleukin-2 (IL-2) and soluble IL-2 receptor secretion in the sera and urine of patients with rickettsial boutonneuse fever. ( 8985208 )
1997
27
Malignant boutonneuse fever and polymyalgia rheumatica: a coincidental association? ( 9334871 )
1997
28
Oculoglandular syndrome in Mediterranean spotted fever acquired through the eye. ( 9059259 )
1997
29
Mediterranean spotted fever mimicking Kawasaki disease. ( 9066481 )
1997
30
Hypertriglyceridemia in Mediterranean spotted fever. ( 9324223 )
1997
31
Depression of CD4 T cell subsets and alteration in cytokine profile in boutonneuse fever. ( 8896508 )
1996
32
Isolation of Rickettsia akari from a patient in a region where Mediterranean spotted fever is endemic. ( 8838175 )
1996
33
Diagnosis of Mediterranean spotted fever by cultivation of Rickettsia conorii from blood and skin samples using the centrifugation-shell vial technique and by detection of R. conorii in circulating endothelial cells: a 6-year follow-up. ( 8897172 )
1996
34
Mediterranean spotted fever: a preliminary tick field study. ( 8905308 )
1996
35
Azithromycin vs. doxycycline for Mediterranean spotted fever. ( 8933556 )
1996
36
Mediterranean spotted fever and arthritis: comment on the article by Sundy et al. ( 8961921 )
1996
37
Release of soluble tumor necrosis factor receptors in Mediterranean spotted fever rickettsiosis. ( 8991643 )
1996
38
Immunoblot cross-reactions among Rickettsia, Proteus spp. and Legionella spp. in patients with Mediterranean spotted fever. ( 7541270 )
1995
39
Acute renal failure as a complication of Mediterranean spotted fever. ( 7753272 )
1995
40
Canine seroprevalence of Rickettsia conorii infection (Mediterranean spotted fever) in Castilla y León (northwest Spain). ( 8549737 )
1995
41
Antiphospholipid antibody production during Mediterranean spotted fever. ( 8679900 )
1995
42
High levels of interferon-gamma in boutonneuse fever. ( 7996014 )
1994
43
[Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. ( 8059165 )
1994
44
Plasma levels of tumor necrosis factor alpha in patients with Mediterranean spotted fever: clinical and analytical correlations. ( 7888547 )
1994
45
Western blot as a seroepidemiologic tool for detecting foci of Mediterranean spotted fever (MSF). ( 7957788 )
1994
46
Involvement of the kidneys in Mediterranean spotted fever and murine typhus. ( 8153286 )
1994
47
Enhanced thromboxane biosynthesis in patients with Mediterranean spotted fever. ( 8180409 )
1994
48
Mediterranean Spotted Fever in Central Tunisia. ( 9815320 )
1994
49
Arthritis in Mediterranean spotted fever. An immune complex mediated synovitis. ( 8339144 )
1993
50
Mediterranean spotted fever in Marseille, France: correlation between prevalence of hospitalized patients, seroepidemiology, and prevalence of infected ticks in three different areas. ( 8447529 )
1993

Variations for Boutonneuse Fever

Expression for Boutonneuse Fever

Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for Boutonneuse Fever

GO Terms for Boutonneuse Fever

Cellular components related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CP IL2 SELE SERPINA1 THBD

Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of inflammatory response GO:0050729 9.4 IL2 TLR4
2 regulation of inflammatory response GO:0050727 9.37 SELE TLR4
3 hemostasis GO:0007599 9.32 SERPINA1 THBD
4 positive regulation of interferon-gamma production GO:0032729 9.26 IL2 TLR4
5 positive regulation of B cell proliferation GO:0030890 9.16 IL2 TLR4
6 response to lipopolysaccharide GO:0032496 9.13 SELE THBD TLR4
7 leukocyte tethering or rolling GO:0050901 8.62 SELE SELL

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.43 SELE THBD TLR4
2 carbohydrate binding GO:0030246 9.33 IL2 SELE SELL
3 oligosaccharide binding GO:0070492 8.96 SELE SELL
4 glycosphingolipid binding GO:0043208 8.62 IL2 SELL

Sources for Boutonneuse Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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