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MCID: BTN002
MIFTS: 42

Boutonneuse Fever

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Boutonneuse Fever

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MalaCards integrated aliases for Boutonneuse Fever:

Name: Boutonneuse Fever 12 58 44 15 17 71
Mediterranean Spotted Fever 12 58 54
African Tick Typhus 12 58
Rickettsia Conorii Spotted Fever 12
South African Tick-Bite Fever 12
Conor and Bruch's Disease 12
Mediterranean Tick Fever 12
African Tick Bite Fever 71
Boutonneuse Disease 12
Kenyan Tick Typhus 12
Kenya Tick Typhus 12
Marseilles Fever 12
Kenya Fever 12

Characteristics:

Orphanet epidemiological data:

58
boutonneuse fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
african tick typhus
Inheritance: Not applicable;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14095
ICD9CM 34 082.1
MeSH 44 D001907
SNOMED-CT 67 186779000
ICD10 32 A77.1
MESH via Orphanet 45 D001907
ICD10 via Orphanet 33 A77.1
UMLS via Orphanet 72 C0006060
UMLS 71 C0006060 C1320317
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Summaries for Boutonneuse Fever

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Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary : Boutonneuse Fever, also known as mediterranean spotted fever, is related to brucellosis and vasculitis, and has symptoms including fever, eschar and regional adenopathy. An important gene associated with Boutonneuse Fever is TLR4 (Toll Like Receptor 4), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include endothelial, skin and eye, and related phenotypes are fever and abnormality of the plantar skin of foot

Wikipedia : 74 Boutonneuse fever (also called, Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus,... more...

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Related Diseases for Boutonneuse Fever

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Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Related Disease Score Top Affiliating Genes
1 brucellosis 30.9 TLR4 SELL IL2
2 vasculitis 30.5 THBD SERPINA1 SELL SELE
3 proteasome-associated autoinflammatory syndrome 1 30.4 TLR4 SELL SELE
4 pleurisy 30.3 TLR4 SELL IL2
5 vascular disease 30.3 TLR4 THBD SELE IL2
6 thrombocytopenia 30.2 TLR4 THBD SELL SELE IL2
7 flinders island spotted fever 30.1 PLEKHG4 AFF2
8 disease by infectious agent 30.0 TLR4 SERPINA1 IL2RB IL2
9 respiratory failure 29.9 TLR4 THBD SERPINA1 G6PD
10 spotted fever 29.7 THBD SPTBN2 PPP1R14A PLEKHG4 CS AFF2
11 indian tick typhus 29.6 PPP1R14A PLEKHG4 AFF2
12 israeli tick typhus 29.6 SPTBN2 PPP1R14A PLEKHG4
13 rocky mountain spotted fever 29.0 SPTBN2 PPP1R14A PLEKHG4 PATL2 CS AFF2
14 epidemic typhus 29.0 SPTBN2 PPP1R14A PLEKHG4 PATL2 CS AFF2
15 endemic typhus 28.8 SPTBN2 PPP1R14A PLEKHG4 CS AFF2
16 african tick-bite fever 11.6
17 exanthem 10.6
18 acute kidney failure 10.5
19 kidney disease 10.4
20 splenomegaly 10.4
21 encephalitis 10.3
22 headache 10.3
23 spotted fever rickettsiosis 10.3
24 metal allergy 10.3 TLR4 IL2
25 fixed drug eruption 10.3 SELL IL2
26 virus associated hemophagocytic syndrome 10.3 IL2RB IL2
27 anca-associated vasculitis 10.3 SERPINA1 IL2
28 superficial basal cell carcinoma 10.3 TLR4 IL2
29 subacute lymphocytic thyroiditis 10.3 SELL IL2
30 gallbladder melanoma 10.3 IL2 G6PD
31 immunodeficiency 63 with lymphoproliferation and autoimmunity 10.3 IL2RB IL2
32 shwartzman phenomenon 10.3 SELE IL2RB
33 alcohol dependence 10.3
34 glucosephosphate dehydrogenase deficiency 10.3
35 hereditary angioedema with normal c1inh 10.3 TLR4 SERPINA1
36 q fever 10.3
37 plague 10.3 TLR4 SELE IL2
38 plummer's disease 10.3 SELL SELE
39 aphthous stomatitis 10.3 TLR4 SELE IL2
40 critical illness polyneuropathy 10.2 SELE CS
41 granulosa cell tumor of the ovary 10.2 SERPINA1 CP
42 berylliosis 10.2 IL2RB IL2
43 toxicodendron dermatitis 10.2 SELL SELE IL2
44 hypotrichosis 1 10.2 TLR4 SELL IL2
45 granulocytopenia 10.2 SELL CP
46 meningoencephalitis 10.2
47 encephalopathy 10.2
48 spondyloarthropathy 10.2 SELL SELE IL2
49 chronic active epstein-barr virus infection 10.2 THBD SELE IL2
50 spinocerebellar ataxia 18 10.2 SPTBN2 PLEKHG4

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to Boutonneuse Fever
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Symptoms & Phenotypes for Boutonneuse Fever

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Human phenotypes related to Boutonneuse Fever:

58 31 (show all 27)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fever 58 31 hallmark (90%) Very frequent (99-80%) HP:0001945
2 abnormality of the plantar skin of foot 58 31 hallmark (90%) Very frequent (99-80%) HP:0100872
3 abnormal skin morphology of the palm 31 hallmark (90%) HP:0040211
4 renal insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0000083
5 elevated hepatic transaminase 58 31 frequent (33%) Frequent (79-30%) HP:0002910
6 thrombocytopenia 58 31 frequent (33%) Frequent (79-30%) HP:0001873
7 arthralgia 58 31 frequent (33%) Frequent (79-30%) HP:0002829
8 myalgia 58 31 frequent (33%) Frequent (79-30%) HP:0003326
9 macule 58 31 frequent (33%) Frequent (79-30%) HP:0012733
10 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
11 cervical lymphadenopathy 58 31 frequent (33%) Frequent (79-30%) HP:0025289
12 skin nodule 58 31 frequent (33%) Frequent (79-30%) HP:0200036
13 increased circulating igm level 58 31 frequent (33%) Frequent (79-30%) HP:0003496
14 maculopapular exanthema 58 31 frequent (33%) Frequent (79-30%) HP:0040186
15 skin detachment 58 31 frequent (33%) Frequent (79-30%) HP:0032156
16 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
17 petechiae 58 31 occasional (7.5%) Occasional (29-5%) HP:0000967
18 diarrhea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002014
19 leukopenia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001882
20 increased circulating igg level 58 31 occasional (7.5%) Occasional (29-5%) HP:0003237
21 nausea 58 31 occasional (7.5%) Occasional (29-5%) HP:0002018
22 photophobia 58 31 very rare (1%) Very rare (<4-1%) HP:0000613
23 vasculitis 58 31 very rare (1%) Very rare (<4-1%) HP:0002633
24 respiratory failure 58 31 very rare (1%) Very rare (<4-1%) HP:0002878
25 skin rash 58 Very frequent (99-80%)
26 lymphadenopathy 58 Frequent (79-30%)
27 abnormality of the skin of the palm 58 Very frequent (99-80%)

Symptoms:

12
  • • fever
  • • eschar
  • • regional adenopathy
  • • maculopapular rash on extremities

MGI Mouse Phenotypes related to Boutonneuse Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.17 CP IL2 IL2RB SELE SELL THBD
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Drugs & Therapeutics for Boutonneuse Fever

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Search Clinical Trials , NIH Clinical Center for Boutonneuse Fever

Cochrane evidence based reviews: boutonneuse fever

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Genetic Tests for Boutonneuse Fever

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Anatomical Context for Boutonneuse Fever

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MalaCards organs/tissues related to Boutonneuse Fever:

40
Endothelial, Skin, Eye, Kidney
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Publications for Boutonneuse Fever

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Articles related to Boutonneuse Fever:

(show top 50) (show all 701)
# Title Authors PMID Year
1
[Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. 61 54
8059165 1994
2
Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. 61 54
7691249 1993
3
[Mediterranean spotted fever or DEBONEL?] 61
32694046 2020
4
Coexistence of Tick-Borne Pathogens in Ticks Collected from their Hosts in Sardinia: an Update. 61
32557083 2020
5
What's eating you? human flea (Pulex irritans). 61
33465194 2020
6
A Case of Hemophagocytic Lymphohistiocytosis Associated With Mediterranean Spotted Fever in a Healthy 29-Year-Old Female. 61
33072805 2020
7
Mediterranean spotted fever in child and adult patients: investigation from an endemic region in Bulgaria. 61
32997473 2020
8
Cases of Mediterranean spotted fever in southeast of Iran. 61
32685123 2020
9
[Mediterranean spotted fever in a 3-year-old boy treated with doxycycline]. 61
30661869 2020
10
Spatial and temporal trends of Mediterranean spotted fever in Spain, 2005-2015. 61
31839472 2020
11
Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections. 61
31955791 2020
12
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 61
31097370 2019
13
Mediterranean spotted fever in the elderly: a prospective cohort study. 61
30972588 2019
14
South African Tick Bite Fever: An Overview. 61
31700846 2019
15
Global Transcriptomic Profiling of Pulmonary Gene Expression in an Experimental Murine Model of Rickettsia conorii Infection. 61
30857242 2019
16
[Macular atrophy secondary to bilateral involvement in Mediterranean spotted fever]. 61
30683535 2019
17
Mediterranean spotted fever as a cause of septic shock. 61
30976518 2019
18
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. 61
30197269 2019
19
Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection. 61
31024862 2019
20
Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever. 61
30508810 2019
21
Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review. 61
30537329 2018
22
Under-diagnosis of rickettsial disease in clinical practice: A systematic review. 61
29486240 2018
23
Tick- and flea-borne rickettsioses in Tizi-Ouzou, Algeria: Implications for travel medicine. 61
30419355 2018
24
Clinically-diagnosed Mediterranean Spotted Fever in Malta. 61
29462726 2018
25
Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever. 61
30150470 2018
26
[A Rickettsia case caused by Rickettsia conorii]. 61
30522428 2018
27
[Haemophagocytic syndrome secondary to Mediterranean spotted fever]. 61
30006110 2018
28
Black spot or «tache noire» in mediterranean spotted fever. 61
29173984 2018
29
Mediterranean Spotted Fever in Children: Study of a Portuguese Endemic Region. 61
29855412 2018
30
[Symmetrical peripheral gangrene: 4 cases]. 61
29169658 2018
31
Tache Noire in a Patient with Acute Q Fever. 61
29298443 2018
32
First detection of Rickettsia conorii ssp. caspia in Rhipicephalus sanguineus in Zambia. 61
28986641 2017
33
Israeli Spotted Fever in Sicily. Description of two cases and minireview. 61
28408252 2017
34
A retrospective study of the characterization of Rickettsia species in ticks collected from humans. 61
28457821 2017
35
Climate change and the epidemiology of selected tick-borne and mosquito-borne diseases: update from the International Society of Dermatology Climate Change Task Force. 61
27696381 2017
36
Epidemiological evaluation of Mediterranean spotted fever in children of the Karak province in south Jordan. 61
28368858 2017
37
[Rickettsiosis after tick bite: A subtle clinic picture on many occasions, we must be vigilant]. 61
26976382 2017
38
Mediterranean spotted fever in Spain, 1997-2014: Epidemiological situation based on hospitalization records. 61
28355307 2017
39
Mediterranean Spotted Fever: A Rare Non-Endemic Disease in the USA. 61
28191378 2017
40
[Rickettsiosis associated with cerebral infarction: a new case study]. 61
28491211 2017
41
Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp. 61
28775717 2017
42
Mediterranean spotted fever-like illness in Sardinia, Italy: a clinical and microbiological study. 61
27380385 2016
43
Small Regulatory RNAs of Rickettsia conorii. 61
27834404 2016
44
Macrophagic activation syndrome related to an infection by Rickettsia conorii in a child. 61
27642144 2016
45
Rickettsiae and rickettsial diseases in Croatia: Implications for travel medicine. 61
27404664 2016
46
Malignant forms of Mediterranean spotted fever: risk factors for fatal outcomes. 61
27453284 2016
47
Myocarditis in Mediterranean spotted fever: a case report and a review of the literature. 61
28348768 2016
48
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo. 61
27217049 2016
49
Molecular diagnosis of Rickettsia infection in patients from Tunisia. 61
26897395 2016
50
Prevalence of antibodies to Rickettsia conorii in human beings and dogs from Catalonia: a 20-year perspective. 61
26899636 2016
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Variations for Boutonneuse Fever

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Expression for Boutonneuse Fever

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Search GEO for disease gene expression data for Boutonneuse Fever.
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Pathways for Boutonneuse Fever

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Pathways related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 12.71 THBD SERPINA1 SELL SELE IL2RB IL2
2
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 64
11.2 SELL IL2RB IL2
3
Dendritic Cells Developmental Lineage Pathway 64
10.67 THBD SELL IL2
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GO Terms for Boutonneuse Fever

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Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte tethering or rolling GO:0050901 8.96 SELL SELE
2 interleukin-2-mediated signaling pathway GO:0038110 8.62 IL2RB IL2

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.26 SELL SELE IL2 G6PD
2 oligosaccharide binding GO:0070492 9.16 SELL SELE
3 glycosphingolipid binding GO:0043208 8.62 SELL IL2
Sources

Sources for Boutonneuse Fever

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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