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MCID: BTN002
MIFTS: 42

Boutonneuse Fever

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Boutonneuse Fever

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MalaCards integrated aliases for Boutonneuse Fever:

Name: Boutonneuse Fever 12 58 43 15 17 71
Mediterranean Spotted Fever 12 58 54
African Tick Typhus 12 58
Rickettsia Conorii Spotted Fever 12
South African Tick-Bite Fever 12
Conor and Bruch's Disease 12
Mediterranean Tick Fever 12
African Tick Bite Fever 71
Boutonneuse Disease 12
Kenyan Tick Typhus 12
Kenya Tick Typhus 12
Marseilles Fever 12
Kenya Fever 12

Characteristics:

Orphanet epidemiological data:

58
boutonneuse fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
african tick typhus
Inheritance: Not applicable;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 32 33
Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14095
ICD9CM 34 082.1
MeSH 43 D001907
SNOMED-CT 67 186774005
ICD10 32 A77.1
MESH via Orphanet 44 D001907
ICD10 via Orphanet 33 A77.1
UMLS via Orphanet 72 C0006060
UMLS 71 C0006060 C1320317
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Summaries for Boutonneuse Fever

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Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary : Boutonneuse Fever, also known as mediterranean spotted fever, is related to african tick-bite fever and brucellosis, and has symptoms including fever, eschar and regional adenopathy. An important gene associated with Boutonneuse Fever is SELE (Selectin E), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include skin, endothelial and testes, and related phenotypes are photophobia and renal insufficiency

Wikipedia : 74 Boutonneuse fever (also called, fièvre boutonneuse, Kenya tick typhus, Indian tick typhus, Marseilles... more...

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Related Diseases for Boutonneuse Fever

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Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)
# Related Disease Score Top Affiliating Genes
1 african tick-bite fever 33.5 SELE CS CD40LG
2 brucellosis 30.8 TLR4 SELL IL2 CD40LG
3 pleurisy 30.6 TLR4 SELL IL2
4 vasculitis 30.4 THBD SERPINA1 SELL SELE CD40LG
5 proteasome-associated autoinflammatory syndrome 1 30.4 TLR4 SELL SELE
6 leptospirosis 30.4 SELE IL2 CD40LG
7 neuroretinitis 30.4 CS CD40LG
8 rubella 30.4 TLR4 IL2 CD40LG
9 toxic shock syndrome 30.3 TLR4 IL2 CD40LG
10 neutropenia 30.2 TLR4 IL2 CP CD40LG
11 scrub typhus 30.2 TLR4 CD40LG AFF2
12 myocarditis 30.1 TLR4 IL2 CD40LG
13 vascular disease 30.1 TLR4 THBD SELE IL2 CD40LG
14 celiac disease 1 30.1 TLR4 SERPINA1 IL2 CD40LG
15 allergic hypersensitivity disease 30.1 SELL SELE IL2
16 israeli tick typhus 30.1 SPTBN2 RPA4 PLEKHG4
17 spotted fever 30.0 THBD SPTBN2 PLEKHG4 CS CD40LG AFF2
18 kawasaki disease 30.0 SELL SELE IL2 CD40LG
19 pneumonia 29.8 TLR4 SERPINA1 SELL IL2 CD40LG
20 thrombocytopenia 29.8 TLR4 THBD SELL SELE IL2 CD40LG
21 diarrhea 29.8 TLR4 THBD SERPINA1 IL2 CD40LG
22 hemolytic anemia 29.7 THBD IL2 G6PD CD40LG
23 respiratory failure 29.7 TLR4 THBD SERPINA1 G6PD CD40LG
24 indian tick typhus 29.6 RPA4 PLEKHG4 CD40LG AFF2
25 rocky mountain spotted fever 29.3 SPTBN2 PLEKHG4 PATL2 CS CD40LG AFF2
26 immune deficiency disease 29.2 SELL IL2RB IL2 CD40LG
27 epidemic typhus 29.1 TLR4 SPTBN2 PLEKHG4 PATL2 CS CD40LG
28 exanthem 10.7
29 virus associated hemophagocytic syndrome 10.5 IL2RB IL2
30 fixed drug eruption 10.5 SELL IL2
31 macular degeneration, age-related, 9 10.5 SELL SELE
32 acute kidney failure 10.4
33 gallbladder melanoma 10.4 IL2 G6PD
34 superficial basal cell carcinoma 10.4 TLR4 IL2
35 shwartzman phenomenon 10.4 TLR4 SELE IL2RB
36 heterophyiasis 10.4 SELE CD40LG
37 enterocolitis 10.4 TLR4 THBD
38 critical illness polyneuropathy 10.4 SELE CS
39 aphthous stomatitis 10.4 TLR4 SELE IL2
40 toxicodendron dermatitis 10.4 SELL SELE IL2
41 contact dermatitis 10.4 TLR4 SELE IL2
42 q fever 10.4
43 hereditary angioedema with normal c1inh 10.4 TLR4 SERPINA1
44 listeriosis 10.3 TLR4 SELL IL2
45 kidney disease 10.3
46 chronic active epstein-barr virus infection 10.3 THBD SELE IL2
47 b-cell expansion with nfkb and t-cell anergy 10.3 SELL IL2RB IL2
48 spinocerebellar ataxia 18 10.3 SPTBN2 PLEKHG4
49 mental retardation, x-linked, associated with fragile site fraxe 10.3 SERPINA1 AFF2
50 plummer's disease 10.3 SELL SELE

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to Boutonneuse Fever
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Symptoms & Phenotypes for Boutonneuse Fever

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Human phenotypes related to Boutonneuse Fever:

58 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 photophobia 58 Very rare (<4-1%)
2 renal insufficiency 58 Frequent (79-30%)
3 fever 58 Very frequent (99-80%)
4 skin rash 58 Very frequent (99-80%)
5 arthralgia 58 Frequent (79-30%)
6 macule 58 Frequent (79-30%)
7 abdominal pain 58 Occasional (29-5%)
8 myalgia 58 Frequent (79-30%)
9 elevated hepatic transaminase 58 Frequent (79-30%)
10 thrombocytopenia 58 Frequent (79-30%)
11 petechiae 58 Occasional (29-5%)
12 vasculitis 58 Very rare (<4-1%)
13 headache 58 Frequent (79-30%)
14 respiratory failure 58 Very rare (<4-1%)
15 lymphadenopathy 58 Frequent (79-30%)
16 diarrhea 58 Occasional (29-5%)
17 leukopenia 58 Occasional (29-5%)
18 cervical lymphadenopathy 58 Frequent (79-30%)
19 skin nodule 58 Frequent (79-30%)
20 increased circulating igm level 58 Frequent (79-30%)
21 maculopapular exanthema 58 Frequent (79-30%)
22 increased circulating igg level 58 Occasional (29-5%)
23 abnormality of the plantar skin of foot 58 Very frequent (99-80%)
24 nausea 58 Occasional (29-5%)
25 abnormality of the skin of the palm 58 Very frequent (99-80%)
26 skin detachment 58 Frequent (79-30%)

Symptoms:

12
  • • fever
  • • eschar
  • • regional adenopathy
  • • maculopapular rash on extremities

MGI Mouse Phenotypes related to Boutonneuse Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.17 CP IL2 IL2RB SELE SELL THBD
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Drugs & Therapeutics for Boutonneuse Fever

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Search Clinical Trials , NIH Clinical Center for Boutonneuse Fever

Cochrane evidence based reviews: boutonneuse fever

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Genetic Tests for Boutonneuse Fever

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Anatomical Context for Boutonneuse Fever

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MalaCards organs/tissues related to Boutonneuse Fever:

40
Skin, Endothelial, Testes, Liver, Eye, Kidney, Colon
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Publications for Boutonneuse Fever

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Articles related to Boutonneuse Fever:

(show top 50) (show all 697)
# Title Authors PMID Year
1
[Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. 54 61
8059165 1994
2
Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. 61 54
7691249 1993
3
Coexistence of Tick-Borne Pathogens in Ticks Collected from their Hosts in Sardinia: an Update. 61
32557083 2020
4
[Mediterranean spotted fever in a 3-year-old boy treated with doxycycline]. 61
30661869 2020
5
Spatial and temporal trends of Mediterranean spotted fever in Spain, 2005-2015. 61
31839472 2020
6
Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections. 61
31955791 2020
7
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 61
31097370 2019
8
Mediterranean spotted fever in the elderly: a prospective cohort study. 61
30972588 2019
9
South African Tick Bite Fever: An Overview. 61
31700846 2019
10
Global Transcriptomic Profiling of Pulmonary Gene Expression in an Experimental Murine Model of Rickettsia conorii Infection. 61
30857242 2019
11
[Macular atrophy secondary to bilateral involvement in Mediterranean spotted fever]. 61
30683535 2019
12
Mediterranean spotted fever as a cause of septic shock. 61
30976518 2019
13
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. 61
30197269 2019
14
Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection. 61
31024862 2019
15
Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever. 61
30508810 2019
16
Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review. 61
30537329 2018
17
Under-diagnosis of rickettsial disease in clinical practice: A systematic review. 61
29486240 2018
18
Tick- and flea-borne rickettsioses in Tizi-Ouzou, Algeria: Implications for travel medicine. 61
30419355 2018
19
Clinically-diagnosed Mediterranean Spotted Fever in Malta. 61
29462726 2018
20
Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever. 61
30150470 2018
21
[A Rickettsia case caused by Rickettsia conorii]. 61
30522428 2018
22
[Haemophagocytic syndrome secondary to Mediterranean spotted fever]. 61
30006110 2018
23
Black spot or «tache noire» in mediterranean spotted fever. 61
29173984 2018
24
Mediterranean Spotted Fever in Children: Study of a Portuguese Endemic Region. 61
29855412 2018
25
[Symmetrical peripheral gangrene: 4 cases]. 61
29169658 2018
26
Tache Noire in a Patient with Acute Q Fever. 61
29298443 2018
27
First detection of Rickettsia conorii ssp. caspia in Rhipicephalus sanguineus in Zambia. 61
28986641 2017
28
Israeli Spotted Fever in Sicily. Description of two cases and minireview. 61
28408252 2017
29
A retrospective study of the characterization of Rickettsia species in ticks collected from humans. 61
28457821 2017
30
Climate change and the epidemiology of selected tick-borne and mosquito-borne diseases: update from the International Society of Dermatology Climate Change Task Force. 61
27696381 2017
31
Epidemiological evaluation of Mediterranean spotted fever in children of the Karak province in south Jordan. 61
28368858 2017
32
[Rickettsiosis after tick bite: A subtle clinic picture on many occasions, we must be vigilant]. 61
26976382 2017
33
Mediterranean Spotted Fever: A Rare Non-Endemic Disease in the USA. 61
28191378 2017
34
[Rickettsiosis associated with cerebral infarction: a new case study]. 61
28491211 2017
35
Mediterranean spotted fever in Spain, 1997-2014: Epidemiological situation based on hospitalization records. 61
28355307 2017
36
Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp. 61
28775717 2017
37
Mediterranean spotted fever-like illness in Sardinia, Italy: a clinical and microbiological study. 61
27380385 2016
38
Small Regulatory RNAs of Rickettsia conorii. 61
27834404 2016
39
Macrophagic activation syndrome related to an infection by Rickettsia conorii in a child. 61
27642144 2016
40
Malignant forms of Mediterranean spotted fever: risk factors for fatal outcomes. 61
27453284 2016
41
Rickettsiae and rickettsial diseases in Croatia: Implications for travel medicine. 61
27404664 2016
42
Myocarditis in Mediterranean spotted fever: a case report and a review of the literature. 61
28348768 2016
43
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo. 61
27217049 2016
44
Prevalence of antibodies to Rickettsia conorii in human beings and dogs from Catalonia: a 20-year perspective. 61
26899636 2016
45
Molecular diagnosis of Rickettsia infection in patients from Tunisia. 61
26897395 2016
46
Human Rickettsia aeschlimannii infection: first case with acute hepatitis and review of the literature. 61
27383315 2016
47
Rickettsia parkeri colonization in Amblyomma maculatum: the role of superoxide dismutases. 61
27206371 2016
48
An embedded microretroreflector-based microfluidic immunoassay platform. 61
27025227 2016
49
Shell-vial culture, coupled with real-time PCR, applied to Rickettsia conorii and Rickettsia massiliae-Bar29 detection, improving the diagnosis of the Mediterranean spotted fever. 61
26830273 2016
50
[Late diagnosis of fatal invasive rickettsial disease in the Intensive Care Unit]. 61
28292166 2016
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Variations for Boutonneuse Fever

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Expression for Boutonneuse Fever

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Search GEO for disease gene expression data for Boutonneuse Fever.
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Pathways for Boutonneuse Fever

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Pathways related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Hematopoietic Stem Cells and Lineage-specific Markers 64
11.56 SELL IL2RB IL2
2
Dendritic Cells Developmental Lineage Pathway 64
11.3 THBD SELL IL2
3
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.13 SELE IL2 CD40LG
4
Malaria 36
10.83 TLR4 SELE CD40LG
5
Inflammatory Response Pathway 1
10.32 IL2RB IL2 CD40LG
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GO Terms for Boutonneuse Fever

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Cellular components related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 TLR4 THBD SELL IL2RB CD40LG
2 external side of plasma membrane GO:0009897 9.02 TLR4 THBD SELL IL2RB CD40LG

Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte tethering or rolling GO:0050901 8.96 SELL SELE
2 interleukin-2-mediated signaling pathway GO:0038110 8.62 IL2RB IL2

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.26 SELL SELE IL2 G6PD
2 oligosaccharide binding GO:0070492 9.16 SELL SELE
3 glycosphingolipid binding GO:0043208 8.62 SELL IL2
Sources

Sources for Boutonneuse Fever

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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