MCID: BTN002
MIFTS: 39

Boutonneuse Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Boutonneuse Fever

MalaCards integrated aliases for Boutonneuse Fever:

Name: Boutonneuse Fever 12 58 43 15 17 71
Mediterranean Spotted Fever 12 58 54
African Tick Typhus 12 58
Rickettsia Conorii Spotted Fever 12
South African Tick-Bite Fever 12
Conor and Bruch's Disease 12
Mediterranean Tick Fever 12
African Tick Bite Fever 71
Boutonneuse Disease 12
Kenyan Tick Typhus 12
Kenya Tick Typhus 12
Marseilles Fever 12
Kenya Fever 12

Characteristics:

Orphanet epidemiological data:

58
boutonneuse fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
african tick typhus
Inheritance: Not applicable;

Classifications:

Orphanet: 58  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14095
ICD9CM 34 082.1
MeSH 43 D001907
SNOMED-CT 67 59742009
ICD10 32 A77.1
MESH via Orphanet 44 D001907
ICD10 via Orphanet 33 A77.1
UMLS via Orphanet 72 C0006060
UMLS 71 C0006060 C1320317

Summaries for Boutonneuse Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary : Boutonneuse Fever, also known as mediterranean spotted fever, is related to african tick-bite fever and pleurisy, and has symptoms including fever, eschar and regional adenopathy. An important gene associated with Boutonneuse Fever is SELE (Selectin E), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include skin, endothelial and kidney, and related phenotype is liver/biliary system.

Wikipedia : 74 Boutonneuse fever (also called, fievre boutonneuse, Kenya tick typhus, Indian tick typhus, Marseilles... more...

Related Diseases for Boutonneuse Fever

Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)
# Related Disease Score Top Affiliating Genes
1 african tick-bite fever 33.4 SELE CS CD40LG
2 pleurisy 30.6 TLR4 SELL IL2
3 proteasome-associated autoinflammatory syndrome 1 30.4 TLR4 SELL SELE
4 vasculitis 30.4 THBD SERPINA1 SELL SELE CD40LG
5 leptospirosis 30.4 SELE IL2 CD40LG
6 flinders island spotted fever 30.4 CS AFF2
7 brucellosis 30.4 TLR4 IL2 CD40LG
8 rubella 30.3 TLR4 IL2 CD40LG
9 neuroretinitis 30.3 CS CD40LG
10 toxic shock syndrome 30.3 TLR4 IL2 CD40LG
11 meningitis 30.3 TLR4 IL2 CD40LG
12 scrub typhus 30.2 TLR4 CD40LG AFF2
13 kawasaki disease 30.2 SELL SELE CD40LG
14 myocarditis 30.2 TLR4 IL2 CD40LG
15 celiac disease 1 30.0 TLR4 IL2RB IL2 CD40LG
16 vascular disease 30.0 TLR4 THBD SELE IL2 CD40LG
17 pfeiffer syndrome 30.0 IL2RB IL2 CD40LG
18 israeli tick typhus 29.9 RPA4 PPP1R14A PLEKHG4
19 pneumonia 29.8 TLR4 SERPINA1 SELL IL2 CD40LG
20 thrombocytopenia 29.8 TLR4 THBD SELL SELE IL2 CD40LG
21 spotted fever 29.4 THBD SPTBN2 PPP1R14A PLEKHG4 CS CD40LG
22 rocky mountain spotted fever 29.3 SPTBN2 PPP1R14A PLEKHG4 CS CD40LG AFF2
23 indian tick typhus 29.1 RPA4 PPP1R14A PLEKHG4 CD40LG AFF2
24 epidemic typhus 29.0 TLR4 SPTBN2 PPP1R14A PLEKHG4 CS CD40LG
25 obsolete: kenya tick typhus 12.7
26 obsolete: mediterranean spotted fever 12.6
27 obsolete: marseilles fever 12.4
28 exanthem 10.7
29 fixed drug eruption 10.5 SELL IL2
30 macular degeneration, age-related, 9 10.5 SELL SELE
31 virus associated hemophagocytic syndrome 10.5 IL2RB IL2
32 acute kidney failure 10.4
33 superficial basal cell carcinoma 10.4 TLR4 IL2
34 heterophyiasis 10.4 SELE CD40LG
35 mental retardation, x-linked, associated with fragile site fraxe 10.4 SERPINA1 AFF2
36 toxicodendron dermatitis 10.4 SELL SELE IL2
37 aphthous stomatitis 10.3 TLR4 SELE IL2
38 plummer's disease 10.3 SELL SELE
39 listeriosis 10.3 TLR4 SELL IL2
40 granulocytopenia 10.3 SELL CP
41 q fever 10.3
42 kidney disease 10.3
43 berylliosis 10.3 IL2RB IL2
44 contact dermatitis 10.3 TLR4 SELE IL2
45 spinocerebellar ataxia 18 10.3 SPTBN2 PLEKHG4
46 b-cell expansion with nfkb and t-cell anergy 10.3 SELL IL2RB IL2
47 chronic active epstein-barr virus infection 10.3 THBD SELE IL2
48 granulosa cell tumor of the ovary 10.3 SERPINA1 CP
49 pneumonic plague 10.3 TLR4 IL2
50 spondyloarthropathy 10.3 SELL SELE IL2

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to Boutonneuse Fever

Symptoms & Phenotypes for Boutonneuse Fever

Symptoms:

12
  • fever
  • eschar
  • regional adenopathy
  • maculopapular rash on extremities

MGI Mouse Phenotypes related to Boutonneuse Fever:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.17 CP IL2 IL2RB SELE SELL THBD

Drugs & Therapeutics for Boutonneuse Fever

Search Clinical Trials , NIH Clinical Center for Boutonneuse Fever

Cochrane evidence based reviews: boutonneuse fever

Genetic Tests for Boutonneuse Fever

Anatomical Context for Boutonneuse Fever

MalaCards organs/tissues related to Boutonneuse Fever:

40
Skin, Endothelial, Kidney, T Cells, Testes, Bone, Liver

Publications for Boutonneuse Fever

Articles related to Boutonneuse Fever:

(show top 50) (show all 696)
# Title Authors PMID Year
1
[Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. 54 61
8059165 1994
2
Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. 54 61
7691249 1993
3
Spatial and temporal trends of Mediterranean spotted fever in Spain, 2005-2015. 61
31839472 2020
4
Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections. 61
31955791 2020
5
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 61
31097370 2019
6
Mediterranean spotted fever in the elderly: a prospective cohort study. 61
30972588 2019
7
South African Tick Bite Fever: An Overview. 61
31700846 2019
8
Global Transcriptomic Profiling of Pulmonary Gene Expression in an Experimental Murine Model of Rickettsia conorii Infection. 61
30857242 2019
9
[Macular atrophy secondary to bilateral involvement in Mediterranean spotted fever]. 61
30683535 2019
10
Mediterranean spotted fever as a cause of septic shock. 61
30976518 2019
11
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. 61
30197269 2019
12
[Mediterranean spotted fever in a 3-year-old boy treated with doxycycline]. 61
30661869 2019
13
Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection. 61
31024862 2019
14
Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever. 61
30508810 2019
15
Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review. 61
30537329 2018
16
Under-diagnosis of rickettsial disease in clinical practice: A systematic review. 61
29486240 2018
17
Tick- and flea-borne rickettsioses in Tizi-Ouzou, Algeria: Implications for travel medicine. 61
30419355 2018
18
Clinically-diagnosed Mediterranean Spotted Fever in Malta. 61
29462726 2018
19
Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever. 61
30150470 2018
20
[A Rickettsia case caused by Rickettsia conorii]. 61
30522428 2018
21
[Haemophagocytic syndrome secondary to Mediterranean spotted fever]. 61
30006110 2018
22
Black spot or «tache noire» in mediterranean spotted fever. 61
29173984 2018
23
Mediterranean Spotted Fever in Children: Study of a Portuguese Endemic Region. 61
29855412 2018
24
[Symmetrical peripheral gangrene: 4 cases]. 61
29169658 2018
25
Tache Noire in a Patient with Acute Q Fever. 61
29298443 2018
26
First detection of Rickettsia conorii ssp. caspia in Rhipicephalus sanguineus in Zambia. 61
28986641 2017
27
Israeli Spotted Fever in Sicily. Description of two cases and minireview. 61
28408252 2017
28
A retrospective study of the characterization of Rickettsia species in ticks collected from humans. 61
28457821 2017
29
Climate change and the epidemiology of selected tick-borne and mosquito-borne diseases: update from the International Society of Dermatology Climate Change Task Force. 61
27696381 2017
30
Epidemiological evaluation of Mediterranean spotted fever in children of the Karak province in south Jordan. 61
28368858 2017
31
[Rickettsiosis after tick bite: A subtle clinic picture on many occasions, we must be vigilant]. 61
26976382 2017
32
Mediterranean Spotted Fever: A Rare Non-Endemic Disease in the USA. 61
28191378 2017
33
[Rickettsiosis associated with cerebral infarction: a new case study]. 61
28491211 2017
34
Mediterranean spotted fever in Spain, 1997-2014: Epidemiological situation based on hospitalization records. 61
28355307 2017
35
Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp. 61
28775717 2017
36
Mediterranean spotted fever-like illness in Sardinia, Italy: a clinical and microbiological study. 61
27380385 2016
37
Small Regulatory RNAs of Rickettsia conorii. 61
27834404 2016
38
Macrophagic activation syndrome related to an infection by Rickettsia conorii in a child. 61
27642144 2016
39
Malignant forms of Mediterranean spotted fever: risk factors for fatal outcomes. 61
27453284 2016
40
Rickettsiae and rickettsial diseases in Croatia: Implications for travel medicine. 61
27404664 2016
41
Myocarditis in Mediterranean spotted fever: a case report and a review of the literature. 61
28348768 2016
42
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo. 61
27217049 2016
43
Molecular diagnosis of Rickettsia infection in patients from Tunisia. 61
26897395 2016
44
Prevalence of antibodies to Rickettsia conorii in human beings and dogs from Catalonia: a 20-year perspective. 61
26899636 2016
45
Human Rickettsia aeschlimannii infection: first case with acute hepatitis and review of the literature. 61
27383315 2016
46
Rickettsia parkeri colonization in Amblyomma maculatum: the role of superoxide dismutases. 61
27206371 2016
47
An embedded microretroreflector-based microfluidic immunoassay platform. 61
27025227 2016
48
Shell-vial culture, coupled with real-time PCR, applied to Rickettsia conorii and Rickettsia massiliae-Bar29 detection, improving the diagnosis of the Mediterranean spotted fever. 61
26830273 2016
49
Nonselective Persistence of a Rickettsia conorii Extrachromosomal Plasmid during Mammalian Infection. 61
26755154 2016
50
[Late diagnosis of fatal invasive rickettsial disease in the Intensive Care Unit]. 61
28292166 2016

Variations for Boutonneuse Fever

Expression for Boutonneuse Fever

Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for Boutonneuse Fever

Pathways related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.92 THBD SERPINA1 SELL SELE IL2RB IL2
2 11.56 SELL IL2RB IL2
3 11.3 THBD SELL IL2
4
Show member pathways
11.13 SELE IL2 CD40LG
5 10.83 TLR4 SELE CD40LG
6 10.32 IL2RB IL2 CD40LG

GO Terms for Boutonneuse Fever

Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte tethering or rolling GO:0050901 8.96 SELL SELE
2 interleukin-2-mediated signaling pathway GO:0038110 8.62 IL2RB IL2

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oligosaccharide binding GO:0070492 8.96 SELL SELE
2 glycosphingolipid binding GO:0043208 8.62 SELL IL2

Sources for Boutonneuse Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....