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MCID: BTN002
MIFTS: 43

Boutonneuse Fever

Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes
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Aliases & Classifications for Boutonneuse Fever

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MalaCards integrated aliases for Boutonneuse Fever:

Name: Boutonneuse Fever 12 59 44 15 17 72
Mediterranean Spotted Fever 12 59 55
African Tick Typhus 12 59
Rickettsia Conorii Spotted Fever 12
South African Tick-Bite Fever 12
Conor and Bruch's Disease 12
Mediterranean Tick Fever 12
African Tick Bite Fever 72
Boutonneuse Disease 12
Kenyan Tick Typhus 12
Kenya Tick Typhus 12
Marseilles Fever 12
Kenya Fever 12

Characteristics:

Orphanet epidemiological data:

59
boutonneuse fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
african tick typhus
Inheritance: Not applicable;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases
See all MalaCards categories (disease lists)
ICD10: 33 34
Orphanet: 59  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14095
ICD9CM 35 082.1
MeSH 44 D001907
SNOMED-CT 68 59742009
ICD10 33 A77.1
MESH via Orphanet 45 D001907
ICD10 via Orphanet 34 A77.1
UMLS via Orphanet 73 C0006060
UMLS 72 C0006060 C1320317
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Summaries for Boutonneuse Fever

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Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary : Boutonneuse Fever, also known as mediterranean spotted fever, is related to spotted fever and pleurisy, and has symptoms including fever, eschar and regional adenopathy. An important gene associated with Boutonneuse Fever is SELE (Selectin E), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Affiliated tissues include skin, endothelial and testes, and related phenotypes are cardiovascular system and cellular

Wikipedia : 75 Boutonneuse fever (also called, fiA?vre boutonneuse, Kenya tick typhus, Indian tick typhus, Marseilles... more...

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Related Diseases for Boutonneuse Fever

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Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 spotted fever 30.9 THBD AFF2
2 pleurisy 30.4 SELL IL2
3 brucellosis 30.1 TLR4 IL2
4 toxic shock syndrome 29.9 TLR4 IL2
5 lymphopenia 29.9 SELL IL2
6 proteasome-associated autoinflammatory syndrome 1 29.7 TLR4 SELL SELE
7 vasculitis 29.4 THBD SERPINA1 SELL SELE
8 obsolete: kenya tick typhus 12.7
9 obsolete: mediterranean spotted fever 12.6
10 obsolete: marseilles fever 12.4
11 african tick-bite fever 12.2
12 exanthem 10.7
13 rocky mountain spotted fever 10.5
14 epidemic typhus 10.5
15 acute kidney failure 10.4
16 fascioliasis 10.4 SELE CP
17 plummer's disease 10.4 SELL SELE
18 retinitis pigmentosa 60 10.4 SELL SELE
19 kidney disease 10.3
20 q fever 10.3
21 leukostasis 10.3 SELL SELE
22 leukocyte adhesion deficiency, type i 10.3 SELL SELE
23 toxicodendron dermatitis 10.3 SELL IL2
24 granulocytopenia 10.3 SELL CP
25 fixed drug eruption 10.3 SELL IL2
26 polyarteritis nodosa 10.3 SELL SELE
27 subendocardial myocardial infarction 10.3 SERPINA1 SELE
28 splenomegaly 10.3
29 conjunctivitis 10.3
30 rickettsial disease 10.3
31 ancylostomiasis 10.3 SERPINA1 CP
32 phacolytic glaucoma 10.3 SERPINA1 IL2
33 spotted fever rickettsiosis 10.3
34 granulosa cell tumor of the ovary 10.2 SERPINA1 CP
35 b-cell expansion with nfkb and t-cell anergy 10.2 SELL IL2
36 meningoencephalitis 10.2
37 encephalopathy 10.2
38 glucosephosphate dehydrogenase deficiency 10.2
39 cryoglobulinemia, familial mixed 10.2
40 myositis 10.2
41 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.2
42 hydrops, lactic acidosis, and sideroblastic anemia 10.2
43 pulmonary edema 10.2
44 thrombocytopenia 10.2
45 vascular disease 10.2
46 cryoglobulinemia 10.2
47 meningitis 10.2
48 chronic pyelonephritis 10.2 TLR4 CP
49 variola major 10.2 TLR4 IL2
50 mental retardation, x-linked, associated with fragile site fraxe 10.2 SERPINA1 AFF2

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to Boutonneuse Fever
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Symptoms & Phenotypes for Boutonneuse Fever

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Symptoms:

12
  • • fever
  • • eschar
  • • regional adenopathy
  • • maculopapular rash on extremities

MGI Mouse Phenotypes related to Boutonneuse Fever:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 CP IL2 SELE SELL THBD TLR4
2 cellular MP:0005384 9.8 CP IL2 SELE SELL THBD TLR4
3 hematopoietic system MP:0005397 9.73 CP IL2 SELE SELL THBD TLR4
4 immune system MP:0005387 9.63 CP IL2 SELE SELL THBD TLR4
5 liver/biliary system MP:0005370 9.43 CP IL2 SELE SELL THBD TLR4
6 respiratory system MP:0005388 9.02 IL2 SELE SELL THBD TLR4
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Drugs & Therapeutics for Boutonneuse Fever

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Search Clinical Trials , NIH Clinical Center for Boutonneuse Fever

Cochrane evidence based reviews: boutonneuse fever

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Genetic Tests for Boutonneuse Fever

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Anatomical Context for Boutonneuse Fever

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MalaCards organs/tissues related to Boutonneuse Fever:

41
Skin, Endothelial, Testes, Liver, Kidney, Eye, Colon
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Publications for Boutonneuse Fever

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Articles related to Boutonneuse Fever:

(show top 50) (show all 693)
# Title Authors PMID Year
1
[Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. 9 38
8059165 1994
2
Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. 9 38
7691249 1993
3
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 38
31097370 2019
4
Mediterranean spotted fever in the elderly: a prospective cohort study. 38
30972588 2019
5
Global Transcriptomic Profiling of Pulmonary Gene Expression in an Experimental Murine Model of Rickettsia conorii Infection. 38
30857242 2019
6
[Macular atrophy secondary to bilateral involvement in Mediterranean spotted fever]. 38
30683535 2019
7
Mediterranean spotted fever as a cause of septic shock. 38
30976518 2019
8
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. 38
30197269 2019
9
[Mediterranean spotted fever in a 3-year-old boy treated with doxycycline]. 38
30661869 2019
10
Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection. 38
31024862 2019
11
Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever. 38
30508810 2019
12
Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review. 38
30537329 2018
13
Under-diagnosis of rickettsial disease in clinical practice: A systematic review. 38
29486240 2018
14
Tick- and flea-borne rickettsioses in Tizi-Ouzou, Algeria: Implications for travel medicine. 38
30419355 2018
15
Clinically-diagnosed Mediterranean Spotted Fever in Malta. 38
29462726 2018
16
Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever. 38
30150470 2018
17
[A Rickettsia case caused by Rickettsia conorii]. 38
30522428 2018
18
[Haemophagocytic syndrome secondary to Mediterranean spotted fever]. 38
30006110 2018
19
Black spot or «tache noire» in mediterranean spotted fever. 38
29173984 2018
20
Mediterranean Spotted Fever in Children: Study of a Portuguese Endemic Region. 38
29855412 2018
21
[Symmetrical peripheral gangrene: 4 cases]. 38
29169658 2018
22
Tache Noire in a Patient with Acute Q Fever. 38
29298443 2018
23
First detection of Rickettsia conorii ssp. caspia in Rhipicephalus sanguineus in Zambia. 38
28986641 2017
24
Israeli Spotted Fever in Sicily. Description of two cases and minireview. 38
28408252 2017
25
A retrospective study of the characterization of Rickettsia species in ticks collected from humans. 38
28457821 2017
26
Climate change and the epidemiology of selected tick-borne and mosquito-borne diseases: update from the International Society of Dermatology Climate Change Task Force. 38
27696381 2017
27
Epidemiological evaluation of Mediterranean spotted fever in children of the Karak province in south Jordan. 38
28368858 2017
28
[Rickettsiosis after tick bite: A subtle clinic picture on many occasions, we must be vigilant]. 38
26976382 2017
29
Mediterranean spotted fever in Spain, 1997-2014: Epidemiological situation based on hospitalization records. 38
28355307 2017
30
Mediterranean Spotted Fever: A Rare Non-Endemic Disease in the USA. 38
28191378 2017
31
[Rickettsiosis associated with cerebral infarction: a new case study]. 38
28491211 2017
32
Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp. 38
28775717 2017
33
Mediterranean spotted fever-like illness in Sardinia, Italy: a clinical and microbiological study. 38
27380385 2016
34
Small Regulatory RNAs of Rickettsia conorii. 38
27834404 2016
35
Macrophagic activation syndrome related to an infection by Rickettsia conorii in a child. 38
27642144 2016
36
Malignant forms of Mediterranean spotted fever: risk factors for fatal outcomes. 38
27453284 2016
37
Rickettsiae and rickettsial diseases in Croatia: Implications for travel medicine. 38
27404664 2016
38
Myocarditis in Mediterranean spotted fever: a case report and a review of the literature. 38
28348768 2016
39
Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo. 38
27217049 2016
40
Prevalence of antibodies to Rickettsia conorii in human beings and dogs from Catalonia: a 20-year perspective. 38
26899636 2016
41
Molecular diagnosis of Rickettsia infection in patients from Tunisia. 38
26897395 2016
42
Human Rickettsia aeschlimannii infection: first case with acute hepatitis and review of the literature. 38
27383315 2016
43
Rickettsia parkeri colonization in Amblyomma maculatum: the role of superoxide dismutases. 38
27206371 2016
44
An embedded microretroreflector-based microfluidic immunoassay platform. 38
27025227 2016
45
Shell-vial culture, coupled with real-time PCR, applied to Rickettsia conorii and Rickettsia massiliae-Bar29 detection, improving the diagnosis of the Mediterranean spotted fever. 38
26830273 2016
46
Nonselective Persistence of a Rickettsia conorii Extrachromosomal Plasmid during Mammalian Infection. 38
26755154 2016
47
Endothelial Cell Proteomic Response to Rickettsia conorii Infection Reveals Activation of the Janus Kinase (JAK)-Signal Transducer and Activator of Transcription (STAT)-Inferferon Stimulated Gene (ISG)15 Pathway and Reprogramming Plasma Membrane Integrin/Cadherin Signaling. 38
26560068 2016
48
[Late diagnosis of fatal invasive rickettsial disease in the Intensive Care Unit]. 38
28292166 2016
49
Differences in Intracellular Fate of Two Spotted Fever Group Rickettsia in Macrophage-Like Cells. 38
27525249 2016
50
A Rare Case of Mediterranean Spotted Fever and Encephalitis. 38
28053795 2016
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Variations for Boutonneuse Fever

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Expression for Boutonneuse Fever

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Search GEO for disease gene expression data for Boutonneuse Fever.
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Pathways for Boutonneuse Fever

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Pathways related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 66
Show member pathways
 12.43 THBD SERPINA1 SELL SELE IL2
2
Cell surface interactions at the vascular wall 66
Show member pathways
 11.58 THBD SELL SELE
3
Glucocorticoid receptor regulatory network 1
11.32 SELE IL2
4
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.17 SELE IL2
5
Malaria 37
11.01 TLR4 SELE
6
Cell adhesion_Cell-matrix glycoconjugates 22
10.85 SELL SELE
7
Dendritic Cells Developmental Lineage Pathway 65
10.67 THBD SELL IL2
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GO Terms for Boutonneuse Fever

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Cellular components related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 THBD SERPINA1 SELE IL2 CP

Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of inflammatory response GO:0050729 9.4 TLR4 IL2
2 regulation of inflammatory response GO:0050727 9.37 TLR4 SELE
3 hemostasis GO:0007599 9.32 THBD SERPINA1
4 positive regulation of interferon-gamma production GO:0032729 9.26 TLR4 IL2
5 positive regulation of B cell proliferation GO:0030890 9.16 TLR4 IL2
6 response to lipopolysaccharide GO:0032496 9.13 TLR4 THBD SELE
7 leukocyte tethering or rolling GO:0050901 8.62 SELL SELE

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.43 TLR4 THBD SELE
2 carbohydrate binding GO:0030246 9.33 SELL SELE IL2
3 oligosaccharide binding GO:0070492 8.96 SELL SELE
4 glycosphingolipid binding GO:0043208 8.62 SELL IL2
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Sources for Boutonneuse Fever

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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