MCID: BTN002
MIFTS: 45

Boutonneuse Fever

Categories: Infectious diseases, Rare diseases

Aliases & Classifications for Boutonneuse Fever

MalaCards integrated aliases for Boutonneuse Fever:

Name: Boutonneuse Fever 12 60 45 15 17 74
Mediterranean Spotted Fever 12 60 56
African Tick Typhus 12 60
Rickettsia Conorii Spotted Fever 12
South African Tick-Bite Fever 12
Conor and Bruch's Disease 12
Mediterranean Tick Fever 12
African Tick Bite Fever 74
Boutonneuse Disease 12
Kenyan Tick Typhus 12
Kenya Tick Typhus 12
Marseilles Fever 12
Kenya Fever 12

Characteristics:

Orphanet epidemiological data:

60
boutonneuse fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;
african tick typhus
Inheritance: Not applicable;

Classifications:

Orphanet: 60  
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:14095
ICD9CM 36 082.1
MeSH 45 D001907
SNOMED-CT 69 59742009
ICD10 34 A77.1
MESH via Orphanet 46 D001907
ICD10 via Orphanet 35 A77.1
UMLS via Orphanet 75 C0006060

Summaries for Boutonneuse Fever

Disease Ontology : 12 A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary : Boutonneuse Fever, also known as mediterranean spotted fever, is related to spotted fever and vasculitis, and has symptoms including fever, eschar (usually single) and regional adenopathy. An important gene associated with Boutonneuse Fever is SELE (Selectin E), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Cell surface interactions at the vascular wall. Affiliated tissues include skin, endothelial and t cells, and related phenotypes are cardiovascular system and cellular

Wikipedia : 77 Boutonneuse fever (also called Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus,... more...

Related Diseases for Boutonneuse Fever

Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 spotted fever 30.5 AFF2 THBD
2 vasculitis 29.5 SELE SELL SERPINA1 THBD
3 african tick-bite fever 12.1
4 arthritis 10.3
5 rocky mountain spotted fever 10.3
6 fascioliasis 10.3 CP SELE
7 encephalitis 10.2
8 chronic pyelonephritis 10.2 CP TLR4
9 retinitis pigmentosa 60 10.2 SELE SELL
10 plummer's disease 10.2 SELE SELL
11 bacterial sepsis 10.2 SELE TLR4
12 leukostasis 10.2 SELE SELL
13 leukocyte adhesion deficiency, type i 10.2 SELE SELL
14 granulocytopenia 10.2 CP SELL
15 epidemic typhus 10.2
16 endemic typhus 10.2
17 encephalopathy 10.2
18 polyarteritis nodosa 10.2 SELE SELL
19 subendocardial myocardial infarction 10.2 SELE SERPINA1
20 periodontosis 10.2 SELL TLR4
21 mitochondrial import-stimulating factor 10.2
22 ancylostomiasis 10.2 CP SERPINA1
23 salmonellosis 10.2 CP TLR4
24 granulosa cell tumor of the ovary 10.1 CP SERPINA1
25 temporal arteritis 10.1
26 depression 10.1
27 variola major 10.1 IL2 TLR4
28 mental retardation, x-linked, associated with fragile site fraxe 10.1 AFF2 SERPINA1
29 pneumoconiosis 10.1 CP SERPINA1
30 q fever 10.1
31 pancytopenia 10.1
32 pericarditis 10.1
33 toxicodendron dermatitis 10.1 IL2 SELL
34 fixed drug eruption 10.1 IL2 SELL
35 paracoccidioidomycosis 10.0 IL2 TLR4
36 phacolytic glaucoma 10.0 IL2 SERPINA1
37 brucellosis 10.0 IL2 TLR4
38 b-cell expansion with nfkb and t-cell anergy 10.0 IL2 SELL
39 filariasis 10.0 IL2 TLR4
40 pleurisy 10.0 IL2 SELL
41 proteasome-associated autoinflammatory syndrome 1 10.0 SELE SELL TLR4
42 grange syndrome 10.0 SELE THBD
43 primary bacterial infectious disease 10.0 IL2 TLR4
44 diabetic angiopathy 10.0 SELE THBD
45 visceral leishmaniasis 10.0 IL2 TLR4
46 thrombotic thrombocytopenic purpura 10.0 SELE THBD
47 toxic shock syndrome 9.9 IL2 TLR4
48 pfeiffer syndrome 9.9
49 hypertriglyceridemia, familial 9.9
50 stroke, ischemic 9.9

Graphical network of the top 20 diseases related to Boutonneuse Fever:



Diseases related to Boutonneuse Fever

Symptoms & Phenotypes for Boutonneuse Fever

Symptoms:

12
  • fever
  • eschar (usually single)
  • regional adenopathy
  • maculopapular rash on extremities

MGI Mouse Phenotypes related to Boutonneuse Fever:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 CP IL2 SELE SELL THBD TLR4
2 cellular MP:0005384 9.8 CP IL2 SELE SELL THBD TLR4
3 hematopoietic system MP:0005397 9.73 CP IL2 SELE SELL THBD TLR4
4 immune system MP:0005387 9.63 CP IL2 SELE SELL THBD TLR4
5 liver/biliary system MP:0005370 9.43 CP IL2 SELE SELL THBD TLR4
6 respiratory system MP:0005388 9.02 IL2 SELE SELL THBD TLR4

Drugs & Therapeutics for Boutonneuse Fever

Search Clinical Trials , NIH Clinical Center for Boutonneuse Fever

Cochrane evidence based reviews: boutonneuse fever

Genetic Tests for Boutonneuse Fever

Anatomical Context for Boutonneuse Fever

MalaCards organs/tissues related to Boutonneuse Fever:

42
Skin, Endothelial, T Cells, Testes, Liver, Kidney, Eye

Publications for Boutonneuse Fever

Articles related to Boutonneuse Fever:

(show top 50) (show all 252)
# Title Authors Year
1
Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. ( 30197269 )
2019
2
Mediterranean spotted fever in the elderly: a prospective cohort study. ( 30972588 )
2019
3
Mediterranean spotted fever as a cause of septic shock. ( 30976518 )
2019
4
Black spot or «tache noire» in mediterranean spotted fever. ( 29173984 )
2018
5
Clinically-diagnosed Mediterranean Spotted Fever in Malta. ( 29462726 )
2018
6
Mediterranean Spotted Fever in Children: Study of a Portuguese Endemic Region. ( 29855412 )
2018
7
Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever. ( 30150470 )
2018
8
Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever. ( 30508810 )
2018
9
Mediterranean Spotted Fever: A Rare Non-Endemic Disease in the USA. ( 28191378 )
2017
10
Mediterranean spotted fever in Spain, 1997-2014: Epidemiological situation based on hospitalization records. ( 28355307 )
2017
11
Epidemiological evaluation of Mediterranean spotted fever in children of the Karak province in south Jordan. ( 28368858 )
2017
12
A Rare Case of Mediterranean Spotted Fever and Encephalitis. ( 28053795 )
2016
13
Myocarditis in Mediterranean spotted fever: a case report and a review of the literature. ( 28348768 )
2016
14
Shell-vial culture, coupled with real-time PCR, applied to Rickettsia conorii and Rickettsia massiliae-Bar29 detection, improving the diagnosis of the Mediterranean spotted fever. ( 26830273 )
2016
15
Mediterranean spotted fever-like illness in Sardinia, Italy: a clinical and microbiological study. ( 27380385 )
2016
16
Malignant forms of Mediterranean spotted fever: risk factors for fatal outcomes. ( 27453284 )
2016
17
Mediterranean spotted fever with lymphangitis occurring from a tick bite lesion. A case in Spain. ( 26173583 )
2015
18
Mediterranean spotted fever and hearing impairment: a rare complication. ( 25892247 )
2015
19
Mediterranean spotted fever: case series of 24 years (1989-2012). ( 26090319 )
2015
20
Mediterranean spotted fever: an unusual clinical and neuroradiological presentation. ( 26152799 )
2015
21
A case of Mediterranean spotted fever associated with severe respiratory distress syndrome. ( 26344605 )
2015
22
Randomized Trial of Clarithromycin for Mediterranean Spotted Fever. ( 26711765 )
2015
23
Malignant Mediterranean spotted fever. ( 26904440 )
2015
24
T-Lymphocyte Subset Absolute Counts in the Peripheral Blood of Mediterranean Spotted Fever Patients: Relations to Disease Severity. ( 26933778 )
2015
25
Mediterranean spotted fever in a patient with Crohn's disease under adalimumab: First case report and review of the literature. ( 25073681 )
2015
26
Incidence of Mediterranean spotted fever in Sicilian children: a clinical-epidemiological observational retrospective study from 1987 to 2010. ( 25461654 )
2015
27
A rare case of retinal artery occlusion in the context of mediterranean spotted Fever. ( 24596555 )
2014
28
Mediterranean spotted fever in children in the Pazardjik region, South Bulgaria. ( 24263221 )
2014
29
First case of Mediterranean spotted fever-associated rhabdomyolysis leading to fatal acute renal failure and encephalitis. ( 24846600 )
2014
30
Q fever and Mediterranean spotted fever associated with hemophagocytic syndrome: case study and literature review. ( 23402798 )
2013
31
Molecular characterization of mediterranean spotted fever rickettsia isolated from a European traveler in the state of São Paulo, Brazil. ( 23279233 )
2013
32
Mediterranean spotted fever with involvement of the gastrointestinal tract. ( 23880573 )
2013
33
Changes of Bcl-2, Bax and Caspase-3 expression in the dermal microvascular endothelial cells and the epidermal layers of the eschar (tache noire) in patients with Mediterranean spotted fever. ( 23907941 )
2013
34
Mediterranean spotted fever in southeastern Romania. ( 24024190 )
2013
35
Clinical, epidemiological and pathogenetic aspects of tick-borne rickettsiosis--Mediterranean spotted fever. ( 24191409 )
2013
36
Levels of certain endothelial biomarkers during the acute phase and convalescence in patients with different severity of Mediterranean spotted fever. ( 24712278 )
2013
37
Mediterranean spotted fever and encephalitis: a case report and review of the literature. ( 21879306 )
2012
38
Rickettsia monacensis as cause of Mediterranean spotted fever-like illness, Italy. ( 22469314 )
2012
39
A 9-year-old girl with a facial black spot. Mediterranean spotted fever. ( 22568439 )
2012
40
Some epidemiological features of the Mediterranean spotted fever re-emerging in Bulgaria. ( 22908829 )
2012
41
Mediterranean spotted fever in the Trakya region of Turkey. ( 23168048 )
2012
42
Mediterranean spotted fever--classification by disease course and criteria for determining the disease severity. ( 23441470 )
2012
43
Mediterranean spotted fever presenting as an acute pancreatitis. ( 21563660 )
2011
44
Analysis of risk factors for malignant Mediterranean spotted fever indicates that fluoroquinolone treatment has a deleterious effect. ( 21642652 )
2011
45
Dynamics in serum cytokine responses during acute and convalescent stages of Mediterranean spotted fever. ( 21797105 )
2011
46
Coronary involvement in Mediterranean spotted fever. ( 22143818 )
2011
47
Soluble CD40L in Mediterranean Spotted Fever: relation to oxidative stress and platelet activation. ( 19647293 )
2010
48
Fatal Mediterranean spotted fever in Greece. ( 19673967 )
2010
49
Diversity of life-threatening complications due to Mediterranean spotted fever in returning travelers. ( 20412176 )
2010
50
Severe Mediterranean spotted fever complicated by acute renal failure and herpetic oesophagitis. ( 20508004 )
2010

Variations for Boutonneuse Fever

Expression for Boutonneuse Fever

Search GEO for disease gene expression data for Boutonneuse Fever.

Pathways for Boutonneuse Fever

GO Terms for Boutonneuse Fever

Cellular components related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 CP IL2 SELE SERPINA1 THBD

Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of inflammatory response GO:0050729 9.4 IL2 TLR4
2 regulation of inflammatory response GO:0050727 9.37 SELE TLR4
3 hemostasis GO:0007599 9.32 SERPINA1 THBD
4 positive regulation of interferon-gamma production GO:0032729 9.26 IL2 TLR4
5 positive regulation of B cell proliferation GO:0030890 9.16 IL2 TLR4
6 response to lipopolysaccharide GO:0032496 9.13 SELE THBD TLR4
7 leukocyte tethering or rolling GO:0050901 8.62 SELE SELL

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.43 SELE THBD TLR4
2 carbohydrate binding GO:0030246 9.33 IL2 SELE SELL
3 oligosaccharide binding GO:0070492 8.96 SELE SELL
4 glycosphingolipid binding GO:0043208 8.62 IL2 SELL

Sources for Boutonneuse Fever

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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