Boutonneuse Fever disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: BTN002 MIFTS: 39	Boutonneuse Fever Categories: Infectious diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Expand all tables

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Aliases & Classifications for Boutonneuse Fever

MalaCards integrated aliases for Boutonneuse Fever:

Name: Boutonneuse Fever ¹² ⁵⁸ ⁴³ ¹⁵ ¹⁷ ⁷¹

Mediterranean Spotted Fever ¹² ⁵⁸ ⁵⁴

African Tick Typhus ¹² ⁵⁸

Rickettsia Conorii Spotted Fever ¹²

South African Tick-Bite Fever ¹²

Conor and Bruch's Disease ¹²

Mediterranean Tick Fever ¹²

African Tick Bite Fever ⁷¹

Boutonneuse Disease ¹²

Kenyan Tick Typhus ¹²

Kenya Tick Typhus ¹²

Marseilles Fever ¹²

Kenya Fever ¹²

Characteristics:

Orphanet epidemiological data:

⁵⁸

boutonneuse fever
Inheritance: Not applicable; Age of onset: All ages; Age of death: any age;

african tick typhus
Inheritance: Not applicable;

Classifications:

MalaCards categories:
Global: Infectious diseases Rare diseases

See all MalaCards categories (disease lists)

ICD10: ³² ³³

Certain infectious and parasitic diseases

Rickettsioses

Spotted fever [tick-borne rickettsioses]

Spotted fever due to Rickettsia conorii

Orphanet: ⁵⁸

Rare infectious diseases

External Ids:

Disease Ontology ¹² DOID:14095

ICD9CM ³⁴ 082.1

MeSH ⁴³ D001907

SNOMED-CT ⁶⁷ 59742009

ICD10 ³² A77.1

MESH via Orphanet ⁴⁴ D001907

ICD10 via Orphanet ³³ A77.1

UMLS via Orphanet ⁷² C0006060

Orphanet ⁵⁸ ORPHA101334 ORPHA83313

EFO ¹⁷ EFO_0007179

UMLS ⁷¹ C0006060 C1320317

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Summaries for Boutonneuse Fever

Disease Ontology : ¹² A spotted fever that has material basis in Rickettsia conorii subsp conorii, which is transmitted by dog tick (Rhipicephalus sanguineus). The infection has symptom fever, has symptom eschar (usually single), has symptom regional adenopathy, has symptom maculopapular rash on extremities.

MalaCards based summary : Boutonneuse Fever, also known as mediterranean spotted fever, is related to african tick-bite fever and pleurisy, and has symptoms including fever, eschar and regional adenopathy. An important gene associated with Boutonneuse Fever is SELE (Selectin E), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include skin, endothelial and kidney, and related phenotype is liver/biliary system.

Wikipedia : ⁷⁴ Boutonneuse fever (also called, fievre boutonneuse, Kenya tick typhus, Indian tick typhus, Marseilles... more...

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Related Diseases for Boutonneuse Fever

Diseases related to Boutonneuse Fever via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 223)

#	Related Disease	Score	Top Affiliating Genes
1	african tick-bite fever	33.4	SELE CS CD40LG
2	pleurisy	30.6	TLR4 SELL IL2
3	proteasome-associated autoinflammatory syndrome 1	30.4	TLR4 SELL SELE
4	vasculitis	30.4	THBD SERPINA1 SELL SELE CD40LG
5	leptospirosis	30.4	SELE IL2 CD40LG
6	flinders island spotted fever	30.4	CS AFF2
7	brucellosis	30.4	TLR4 IL2 CD40LG
8	rubella	30.3	TLR4 IL2 CD40LG
9	neuroretinitis	30.3	CS CD40LG
10	toxic shock syndrome	30.3	TLR4 IL2 CD40LG
11	meningitis	30.3	TLR4 IL2 CD40LG
12	scrub typhus	30.2	TLR4 CD40LG AFF2
13	kawasaki disease	30.2	SELL SELE CD40LG
14	myocarditis	30.2	TLR4 IL2 CD40LG
15	celiac disease 1	30.0	TLR4 IL2RB IL2 CD40LG
16	vascular disease	30.0	TLR4 THBD SELE IL2 CD40LG
17	pfeiffer syndrome	30.0	IL2RB IL2 CD40LG
18	israeli tick typhus	29.9	RPA4 PPP1R14A PLEKHG4
19	pneumonia	29.8	TLR4 SERPINA1 SELL IL2 CD40LG
20	thrombocytopenia	29.8	TLR4 THBD SELL SELE IL2 CD40LG
21	spotted fever	29.4	THBD SPTBN2 PPP1R14A PLEKHG4 CS CD40LG
22	rocky mountain spotted fever	29.3	SPTBN2 PPP1R14A PLEKHG4 CS CD40LG AFF2
23	indian tick typhus	29.1	RPA4 PPP1R14A PLEKHG4 CD40LG AFF2
24	epidemic typhus	29.0	TLR4 SPTBN2 PPP1R14A PLEKHG4 CS CD40LG
25	obsolete: kenya tick typhus	12.7
26	obsolete: mediterranean spotted fever	12.6
27	obsolete: marseilles fever	12.4
28	exanthem	10.7
29	fixed drug eruption	10.5	SELL IL2
30	macular degeneration, age-related, 9	10.5	SELL SELE
31	virus associated hemophagocytic syndrome	10.5	IL2RB IL2
32	acute kidney failure	10.4
33	superficial basal cell carcinoma	10.4	TLR4 IL2
34	heterophyiasis	10.4	SELE CD40LG
35	mental retardation, x-linked, associated with fragile site fraxe	10.4	SERPINA1 AFF2
36	toxicodendron dermatitis	10.4	SELL SELE IL2
37	aphthous stomatitis	10.3	TLR4 SELE IL2
38	plummer's disease	10.3	SELL SELE
39	listeriosis	10.3	TLR4 SELL IL2
40	granulocytopenia	10.3	SELL CP
41	q fever	10.3
42	kidney disease	10.3
43	berylliosis	10.3	IL2RB IL2
44	contact dermatitis	10.3	TLR4 SELE IL2
45	spinocerebellar ataxia 18	10.3	SPTBN2 PLEKHG4
46	b-cell expansion with nfkb and t-cell anergy	10.3	SELL IL2RB IL2
47	chronic active epstein-barr virus infection	10.3	THBD SELE IL2
48	granulosa cell tumor of the ovary	10.3	SERPINA1 CP
49	pneumonic plague	10.3	TLR4 IL2
50	spondyloarthropathy	10.3	SELL SELE IL2

Graphical network of the top 20 diseases related to Boutonneuse Fever:

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Symptoms & Phenotypes for Boutonneuse Fever

Symptoms:

¹²

• fever
• eschar

• regional adenopathy
• maculopapular rash on extremities

MGI Mouse Phenotypes related to Boutonneuse Fever:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	liver/biliary system	MP:0005370	9.17	CP IL2 IL2RB SELE SELL THBD

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Drugs & Therapeutics for Boutonneuse Fever

Search Clinical Trials , NIH Clinical Center for Boutonneuse Fever

Cochrane evidence based reviews: boutonneuse fever

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Genetic Tests for Boutonneuse Fever

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Anatomical Context for Boutonneuse Fever

MalaCards organs/tissues related to Boutonneuse Fever:

⁴⁰

Skin, Endothelial, Kidney, T Cells, Testes, Bone, Liver

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Publications for Boutonneuse Fever

Articles related to Boutonneuse Fever:

(show top 50) (show all 696)

#	Title	Authors	PMID	Year
1	[Malignant mediterranean boutonneuse fever in a patient with partial glucose-6-phosphate dehydrogenase deficiency]. ⁵⁴ ⁶¹	Rousseau MC...Bourgeade A	8059165	1994
2	Demonstration of Rickettsia conorii-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. ⁵⁴ ⁶¹	George F...Sampol J	7691249	1993
3	Spatial and temporal trends of Mediterranean spotted fever in Spain, 2005-2015. ⁶¹	Romani Vidal A...Gomez Barroso D	31839472	2020
4	Quantitative Proteomics of the Endothelial Secretome Identifies RC0497 as Diagnostic of Acute Rickettsial Spotted Fever Infections. ⁶¹	Zhao Y...Brasier AR	31955791	2020
5	Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. ⁶¹	Figoni J...endorsed by scientific societies	31097370	2019
6	Mediterranean spotted fever in the elderly: a prospective cohort study. ⁶¹	Espejo E...Bella F	30972588	2019
7	South African Tick Bite Fever: An Overview. ⁶¹	Frean J...Grayson W	31700846	2019
8	Global Transcriptomic Profiling of Pulmonary Gene Expression in an Experimental Murine Model of Rickettsia conorii Infection. ⁶¹	Narra HP...Sahni SK	30857242	2019
9	[Macular atrophy secondary to bilateral involvement in Mediterranean spotted fever]. ⁶¹	Youssoufou Souley AS...Oubaaz A	30683535	2019
10	Mediterranean spotted fever as a cause of septic shock. ⁶¹	Abdeljelil M...Chakroun M	30976518	2019
11	Mediterranean spotted fever rickettsiosis in Italy, 2001-2015: Spatio-temporal distribution based on hospitalization records. ⁶¹	Gomez-Barroso D...Pezzotti P	30197269	2019
12	[Mediterranean spotted fever in a 3-year-old boy treated with doxycycline]. ⁶¹	Magdaleno-Tapial J...Esteve-Martinez A	30661869	2019
13	Macrophages Infected by a Pathogen and a Non-pathogen Spotted Fever Group Rickettsia Reveal Differential Reprogramming Signatures Early in Infection. ⁶¹	Curto P...Martinez JJ	31024862	2019
14	Unusual Maculopapular Rash on the Scalp of a Patient with Mediterranean Spotted Fever. ⁶¹	Baltadzhiev I...Popivanova N	30508810	2019
15	Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review. ⁶¹	Fischer M	30537329	2018
16	Under-diagnosis of rickettsial disease in clinical practice: A systematic review. ⁶¹	van Eekeren LE...Goorhuis A	29486240	2018
17	Tick- and flea-borne rickettsioses in Tizi-Ouzou, Algeria: Implications for travel medicine. ⁶¹	Bouchaib H...Parola P	30419355	2018
18	Clinically-diagnosed Mediterranean Spotted Fever in Malta. ⁶¹	Torpiano P...Pace D	29462726	2018
19	Prospective Cohort Study of Single-Day Doxycycline Therapy for Mediterranean Spotted Fever. ⁶¹	Espejo E...Bella F	30150470	2018
20	[A Rickettsia case caused by Rickettsia conorii]. ⁶¹	Celebi B...Kilic S	30522428	2018
21	[Haemophagocytic syndrome secondary to Mediterranean spotted fever]. ⁶¹	Bertrand AS...Guillot B	30006110	2018
22	Black spot or «tache noire» in mediterranean spotted fever. ⁶¹	Garcia-Fernandez-Bravo I...Del Toro Cervera J	29173984	2018
23	Mediterranean Spotted Fever in Children: Study of a Portuguese Endemic Region. ⁶¹	Peixoto S...Martins V	29855412	2018
24	[Symmetrical peripheral gangrene: 4 cases]. ⁶¹	Smaoui F...Ben Jemaa M	29169658	2018
25	Tache Noire in a Patient with Acute Q Fever. ⁶¹	Fiore V...Madeddu G	29298443	2018
26	First detection of Rickettsia conorii ssp. caspia in Rhipicephalus sanguineus in Zambia. ⁶¹	Chitimia-Dobler L...Wolfel S	28986641	2017
27	Israeli Spotted Fever in Sicily. Description of two cases and minireview. ⁶¹	Colomba C...Cascio A	28408252	2017
28	A retrospective study of the characterization of Rickettsia species in ticks collected from humans. ⁶¹	Blanda V...de la Fuente J	28457821	2017
29	Climate change and the epidemiology of selected tick-borne and mosquito-borne diseases: update from the International Society of Dermatology Climate Change Task Force. ⁶¹	Andersen LK...Davis MD	27696381	2017
30	Epidemiological evaluation of Mediterranean spotted fever in children of the Karak province in south Jordan. ⁶¹	Nafi O...Tarawnah A	28368858	2017
31	[Rickettsiosis after tick bite: A subtle clinic picture on many occasions, we must be vigilant]. ⁶¹	Monterde-Alvarez ML...Escribano-Subias J	26976382	2017
32	Mediterranean Spotted Fever: A Rare Non-Endemic Disease in the USA. ⁶¹	Oaks JB...LaCapra G	28191378	2017
33	[Rickettsiosis associated with cerebral infarction: a new case study]. ⁶¹	Boulahri T...Rouimi A	28491211	2017
34	Mediterranean spotted fever in Spain, 1997-2014: Epidemiological situation based on hospitalization records. ⁶¹	Herrador Z...Benito A	28355307	2017
35	Multi-omics Analysis Sheds Light on the Evolution and the Intracellular Lifestyle Strategies of Spotted Fever Group Rickettsia spp. ⁶¹	El Karkouri K...Raoult D	28775717	2017
36	Mediterranean spotted fever-like illness in Sardinia, Italy: a clinical and microbiological study. ⁶¹	Madeddu G...Mura MS	27380385	2016
37	Small Regulatory RNAs of Rickettsia conorii. ⁶¹	Narra HP...Sahni SK	27834404	2016
38	Macrophagic activation syndrome related to an infection by Rickettsia conorii in a child. ⁶¹	Hsairi M...Hachicha M	27642144	2016
39	Malignant forms of Mediterranean spotted fever: risk factors for fatal outcomes. ⁶¹	Baltadzhiev I...Zaprianov Z	27453284	2016
40	Rickettsiae and rickettsial diseases in Croatia: Implications for travel medicine. ⁶¹	Dzelalija B...Dobec M	27404664	2016
41	Myocarditis in Mediterranean spotted fever: a case report and a review of the literature. ⁶¹	Colomba C...Cascio A	28348768	2016
42	Rickettsia conorii is a potent complement activator in vivo and combined inhibition of complement and CD14 is required for attenuation of the cytokine response ex vivo. ⁶¹	Otterdal K...Nilsson PH	27217049	2016
43	Molecular diagnosis of Rickettsia infection in patients from Tunisia. ⁶¹	Khrouf F...Znazen A	26897395	2016
44	Prevalence of antibodies to Rickettsia conorii in human beings and dogs from Catalonia: a 20-year perspective. ⁶¹	Espejo E...Bella F	26899636	2016
45	Human Rickettsia aeschlimannii infection: first case with acute hepatitis and review of the literature. ⁶¹	Tosoni A...Internal Medicine Sepsis Study Group	27383315	2016
46	Rickettsia parkeri colonization in Amblyomma maculatum: the role of superoxide dismutases. ⁶¹	Crispell G...Karim S	27206371	2016
47	An embedded microretroreflector-based microfluidic immunoassay platform. ⁶¹	Raja B...Willson R	27025227	2016
48	Shell-vial culture, coupled with real-time PCR, applied to Rickettsia conorii and Rickettsia massiliae-Bar29 detection, improving the diagnosis of the Mediterranean spotted fever. ⁶¹	Segura F...Nogueras MM	26830273	2016
49	Nonselective Persistence of a Rickettsia conorii Extrachromosomal Plasmid during Mammalian Infection. ⁶¹	Riley SP...Martinez JJ	26755154	2016
50	[Late diagnosis of fatal invasive rickettsial disease in the Intensive Care Unit]. ⁶¹	Ghezala HB...Feriani N	28292166	2016

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Genes for Boutonneuse Fever

Genes related to Boutonneuse Fever (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SELE	Selectin E	Protein Coding	11.77	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
2	TLR4	Toll Like Receptor 4	Protein Coding	11.44	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	SELL	Selectin L	Protein Coding	10.52	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
4	CP	Ceruloplasmin	Protein Coding	10.5	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
5	THBD	Thrombomodulin	Protein Coding	8.09	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁴	7691249
6	IL2	Interleukin 2	Protein Coding	7.03	GeneCards inferred via : Publications (show sections)
7	IL2RB	Interleukin 2 Receptor Subunit Beta	Protein Coding	7.03	GeneCards inferred via : Publications (show sections)
8	SERPINA1	Serpin Family A Member 1	Protein Coding	7.03	GeneCards inferred via : Publications (show sections)
9	PLEKHG4	Pleckstrin Homology And RhoGEF Domain Containing G4	Protein Coding	6.79	DISEASES inferred ¹⁵
10	SPTBN2	Spectrin Beta, Non-Erythrocytic 2	Protein Coding	6.71	DISEASES inferred ¹⁵
11	AFF2	AF4/FMR2 Family Member 2	Protein Coding	6.42	DISEASES inferred ¹⁵
12	CD40LG	CD40 Ligand	Protein Coding	6.33	DISEASES inferred ¹⁵
13	CS	Citrate Synthase	Protein Coding	6.32	DISEASES inferred ¹⁵
14	RPA4	Replication Protein A4	Protein Coding	6.22	DISEASES inferred ¹⁵
15	IRS4	Insulin Receptor Substrate 4	Protein Coding	6.21	DISEASES inferred ¹⁵
16	NCCRP1	NCCRP1, F-Box Associated Domain Containing	Protein Coding	6.04	DISEASES inferred ¹⁵
17	PPP1R14A	Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A	Protein Coding	5.99	DISEASES inferred ¹⁵

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Variations for Boutonneuse Fever

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Expression for Boutonneuse Fever

Search GEO for disease gene expression data for Boutonneuse Fever.

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Pathways for Boutonneuse Fever

Pathways related to Boutonneuse Fever according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Response to elevated platelet cytosolic Ca2+ ⁶⁵ Show member pathways Disinhibition of SNARE formation ⁶⁵ Hemostasis ⁶⁵ Platelet activation, signaling and aggregation ⁶⁵ Platelet degranulation ⁶⁵	12.92	THBD SERPINA1 SELL SELE IL2RB IL2
2	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.56	SELL IL2RB IL2
3	Dendritic Cells Developmental Lineage Pathway ⁶⁴	11.3	THBD SELL IL2
4	Photodynamic therapy-induced NF-kB survival signaling ¹ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.13	SELE IL2 CD40LG
5	Malaria ³⁶	10.83	TLR4 SELE CD40LG
6	Inflammatory Response Pathway ¹	10.32	IL2RB IL2 CD40LG

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GO Terms for Boutonneuse Fever

Biological processes related to Boutonneuse Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte tethering or rolling	GO:0050901	8.96	SELL SELE
2	interleukin-2-mediated signaling pathway	GO:0038110	8.62	IL2RB IL2

Molecular functions related to Boutonneuse Fever according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	oligosaccharide binding	GO:0070492	8.96	SELL SELE
2	glycosphingolipid binding	GO:0043208	8.62	SELL IL2

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Sources for Boutonneuse Fever

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia