BP
MCID: BWN003
MIFTS: 36

Bowenoid Papulosis (BP)

Categories: Rare diseases

Aliases & Classifications for Bowenoid Papulosis

MalaCards integrated aliases for Bowenoid Papulosis:

Name: Bowenoid Papulosis 53 72
Bp 53

Classifications:



External Ids:

UMLS 72 C0334106

Summaries for Bowenoid Papulosis

MalaCards based summary : Bowenoid Papulosis, also known as bp, is related to papilloma and cervical intraepithelial neoplasia. An important gene associated with Bowenoid Papulosis is CCND1 (Cyclin D1), and among its related pathways/superpathways are Human cytomegalovirus infection and PI3K-Akt signaling pathway. Affiliated tissues include skin, cervix and t cells, and related phenotypes are Reduced mammosphere formation and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 75 Bowenoid papulosis is a cutaneous condition characterized by the presence of pigmented verrucous papules... more...

Related Diseases for Bowenoid Papulosis

Diseases related to Bowenoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 672)
# Related Disease Score Top Affiliating Genes
1 papilloma 31.0 FLG CDKN2A CCND1
2 cervical intraepithelial neoplasia 30.8 TERT CDKN2A
3 squamous cell carcinoma 30.5 PTGS2 CDKN2A CCND1
4 skin carcinoma in situ 30.0 PPARG CDKN2A CCND1
5 nasopharyngeal carcinoma 29.7 TERT CDKN2A CCND1
6 glioblastoma multiforme 29.1 PPARG CDKN2A CCND1
7 glioblastoma 29.1 PPARG CDKN2A CCND1
8 cervical cancer 29.0 TERT PTGS2 CDKN2A CCND1
9 oral cancer 28.9 PTGS2 CDKN2A CCND1
10 adenocarcinoma 28.8 PTGS2 CDKN2A CCND1
11 gastric cancer 28.2 TERT PTGS2 CDKN2A CCND1
12 esophageal cancer 28.1 TERT PTGS2 CDKN2A CCND1
13 colorectal cancer 27.4 TERT PTGS2 PPARG CDKN2A CCND1
14 hepatocellular carcinoma 27.3 TERT PTGS2 CDKN2A CCND1
15 lung cancer 26.7 TERT PTGS2 PPARG CDKN2A CCNE1 CCND1
16 interstitial cystitis 12.3
17 bartsocas-papas syndrome 12.2
18 bullous pemphigoid 11.9
19 leukemia, chronic myeloid 11.3
20 growth hormone insensitivity with immunodeficiency 11.2
21 d-bifunctional protein deficiency 11.2
22 chromosome 15q13.3 deletion syndrome 11.2
23 vertebrobasilar insufficiency 11.2
24 bowen's disease 11.0
25 in situ carcinoma 10.9
26 squamous cell papilloma 10.8
27 suppressor of tumorigenicity 3 10.5
28 anogenital venereal wart 10.5
29 acquired immunodeficiency syndrome 10.5
30 erythroplakia 10.5
31 clear cell adenocarcinoma of the ovary 10.4 CCNE1 CCND1
32 cervix uteri carcinoma in situ 10.4
33 lichen planus 10.4
34 vulvar intraepithelial neoplasia 10.4
35 breast papillomatosis 10.4 CDKN2A CCND1
36 tonsil squamous cell carcinoma 10.4 CDKN2A CCND1
37 endometrial squamous cell carcinoma 10.4 CDKN2A CCND1
38 oral leukoplakia 10.4 CDKN2A CCND1
39 ischemic fasciitis 10.4 CDKN2A CCND1
40 cystitis 10.3
41 verrucous carcinoma 10.3 CDKN2A CCND1
42 thalassemia 10.3
43 pre-malignant neoplasm 10.3 CDKN2A CCND1
44 keratosis, seborrheic 10.3
45 epidermodysplasia verruciformis 1 10.3
46 immune deficiency disease 10.3
47 keratosis 10.3
48 inverted follicular keratosis 10.3
49 chondromyxoid fibroma 10.3 CDKN2A CCND1
50 oropharynx cancer 10.3 CDKN2A CCND1

Graphical network of the top 20 diseases related to Bowenoid Papulosis:



Diseases related to Bowenoid Papulosis

Symptoms & Phenotypes for Bowenoid Papulosis

GenomeRNAi Phenotypes related to Bowenoid Papulosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.26 CCND1 CCNE1 PPARG PTGS2
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.17 CCNE1 CDKN2A TERT
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.17 CCND1 CCNE1 CDKN2A TERT

MGI Mouse Phenotypes related to Bowenoid Papulosis:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.99 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
2 endocrine/exocrine gland MP:0005379 9.95 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
3 growth/size/body region MP:0005378 9.93 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
4 hematopoietic system MP:0005397 9.91 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
5 digestive/alimentary MP:0005381 9.89 CCND1 CCNE1 CDKN2A PTGS2 TERT
6 immune system MP:0005387 9.88 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
7 neoplasm MP:0002006 9.8 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
8 integument MP:0010771 9.77 CCND1 CCNE1 CDKN2A PPARG PTGS2
9 nervous system MP:0003631 9.73 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
10 normal MP:0002873 9.55 CCND1 CCNE1 PPARG PTGS2 TERT
11 reproductive system MP:0005389 9.43 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
12 skeleton MP:0005390 9.1 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT

Drugs & Therapeutics for Bowenoid Papulosis

Search Clinical Trials , NIH Clinical Center for Bowenoid Papulosis

Genetic Tests for Bowenoid Papulosis

Anatomical Context for Bowenoid Papulosis

MalaCards organs/tissues related to Bowenoid Papulosis:

41
Skin, Cervix, T Cells, Tongue, Nk Cells

Publications for Bowenoid Papulosis

Articles related to Bowenoid Papulosis:

(show top 50) (show all 301)
# Title Authors PMID Year
1
Dermatoscopic findings of penile intraepithelial neoplasia: Bowenoid papulosis, Bowen disease and erythroplasia of Queyrat. 38
30585302 2019
2
Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region. 38
30203987 2019
3
Human papillomavirus 34 associated with bowenoid papulosis of the penile shaft. 38
30570779 2019
4
Epidermal mast cells in Bowenoid papulosis during topical imiquimod therapy. 38
30204264 2019
5
Bowenoid papulosis unveiling a rare cause of immunosuppression. 38
30999833 2019
6
Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands. 38
30508877 2019
7
Oral bowenoid papulosis. 38
30566561 2018
8
[Penile intra-epithelial neoplasia]. 38
29937064 2018
9
Genital bowenoid papulosis: the variegated dermoscopic features. 38
29767494 2018
10
Linear ectopic sebaceous hyperplasia of the penis: the last memory of Tyson's glands. 38
27598618 2018
11
Urologic Dermatology: a Review. 38
28667573 2017
12
Vulvar Bowenoid Papulosis: Histologically High-Grade Squamous Intraepithelial Lesion Known to Spontaneously Regress. 38
28452867 2017
13
[HPV-induced penile intra-epithelial neoplasia: Bowenoid papulosis]. 38
28117082 2017
14
Bowenoid papulosis in a linear distribution. 38
27279825 2016
15
Presentation of epidermolytic acanthomas as multiple tan papules on the vulva. 38
27034569 2016
16
Cutaneous squamous cell carcinoma progression is associated with decreased GATA-3 immunohistochemical staining. 38
26762870 2016
17
High-grade squamous intraepithelial lesion of the oral commissure (bowenoid papulosis). A case and review. 38
26693089 2015
18
Bowenoid papulosis. 38
26692627 2015
19
Seborrheic keratosis with bowenoid transformation: the immunohistochemical features and its association with human papillomavirus infection. 38
25747812 2015
20
Traumatic neuroma of the penis after circumcision--Case report. 38
26131873 2015
21
Aminolevulinic acid photodynamic therapy for bowenoid papulosis. 38
25751357 2015
22
[Actinic keratosis, Bowen's disease, keratoacanthoma and squamous cell carcinoma of the skin]. 38
25663185 2015
23
Detection of human papillomavirus (HPV) in patients with squamous cell carcinoma and the clinical characteristics of HPV-positive cases. 38
24980205 2014
24
Dermoscopic findings in bowenoid papulosis: report of two cases. 38
25396088 2014
25
Dramatic clearance of HIV-associated bowenoid papulosis using combined oral acitretin and topical 5% imiquimod. 38
25116965 2014
26
A case of isolated bowenoid papulosis of the nipple. 38
24966640 2014
27
Bowenoid papulosis successfully treated with imiquimod 5% cream. 38
24909216 2014
28
Pigmented Bowen's disease of the penis and scrotum in a patient with AIDS. 38
24746300 2014
29
Pigmented condyloma acuminatum. 38
24611994 2014
30
[Evaluation of hypnosis in pain management during photodynamic therapy: a pilot study]. 38
24635951 2014
31
Cutaneous human papillomavirus infection: manifestations and diagnosis. 38
24643180 2014
32
Extensive bowenoid papulosis of the vulva treated by carbon dioxide laser in a patient with AIDS. 38
23347880 2013
33
Periungual bowenoid papulosis due to human papillomavirus type 42. 38
23375694 2013
34
Expression of p16 protein in lesional and perilesional condyloma acuminata and bowenoid papulosis: clinical significance and diagnostic implications. 38
23706650 2013
35
Expression of activation-induced cytidine deaminase in Bowenoid papulosis. 38
24126385 2013
36
Anogenital malignancies and premalignancies: facts and controversies. 38
23806153 2013
37
[Precancerous tumors and carcinomas in situ of the skin]. 38
23657620 2013
38
Expression of cyclin D1 and cyclin E significantly associates with human papillomavirus subtypes in Bowenoid papulosis. 38
23044415 2013
39
Spontaneous regression of bowenoid papulosis. 38
24011282 2013
40
Bowenoid papulosis and invasive Bowen's disease: a multidisciplinary approach. 38
22717936 2013
41
Whither bowenoid papulosis? 38
23336842 2013
42
Low rate of detection of mucosal high-risk-type human papillomavirus in Korean patients with extragenital Bowen's disease and squamous cell carcinoma, especially in digital cases. 38
24024191 2013
43
A retrospective analysis of real-life practice of off-label photodynamic therapy using methyl aminolevulinate (MAL-PDT) in 20 Italian dermatology departments. Part 2: oncologic and infectious indications. 38
22949076 2013
44
A combined assay of hTERT and E6 oncoprotein to identify virus-infected keratinocytes with higher telomerase activity in human papillomaviruses 16 and 18-related bowenoid papulosis. 38
22688392 2012
45
Multiple linear bowenoid papulosis without surrounding papules. 38
22221073 2012
46
Detection of human papillomavirus type 16 in Bowen's carcinoma of the toe. 38
22715824 2012
47
Coexistence of Bowenoid papulosis and Bowen's disease in a patient with systemic lupus erythematosus. 38
22142328 2012
48
Successful treatment with fluoropyrimidine TS-1 of human papillomavirus type 16-detected multiple oral bowenoid papulosis in an elderly woman. 38
22266463 2012
49
Bowenoid Papulosis of the Vulva and Subsequent Periungual Bowen's Disease Induced by the Same Mucosal HPVs. 38
22148018 2011
50
Cutaneous manifestations of human papillomaviruses: a review. 38
22131115 2011

Variations for Bowenoid Papulosis

Expression for Bowenoid Papulosis

Search GEO for disease gene expression data for Bowenoid Papulosis.

Pathways for Bowenoid Papulosis

Pathways related to Bowenoid Papulosis according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 PTGS2 CDKN2A CCNE1 CCND1
2
Show member pathways
12.63 TERT PTGS2 CCNE1 CCND1
3
Show member pathways
12.45 PPARG CDKN2A CCNE1 CCND1
4
Show member pathways
12.34 TERT CDKN2A CCNE1 CCND1
5
Show member pathways
12.3 CDKN2A CCNE1 CCND1
6 12.24 CDKN2A CCNE1 CCND1
7 12.16 PTGS2 CCNE1 CCND1
8
Show member pathways
12.1 CDKN2A CCNE1 CCND1
9 12.09 TERT CDKN2A CCND1
10 12.07 CDKN2A CCNE1 CCND1
11
Show member pathways
12.05 CDKN2A CCNE1 CCND1
12
Show member pathways
12.01 PTGS2 PPARG CCND1
13 11.96 CDKN2A CCNE1 CCND1
14 11.95 PTGS2 CDKN2A CCNE1 CCND1
15
Show member pathways
11.88 CDKN2A CCNE1 CCND1
16 11.82 TERT PTGS2 PPARG CDKN2A CCNE1 CCND1
17 11.81 CDKN2A CCNE1 CCND1
18
Show member pathways
11.72 PTGS2 CCNE1 CCND1
19
Show member pathways
11.54 PTGS2 PPARG
20 11.54 CDKN2A CCNE1 CCND1
21 11.52 CDKN2A CCND1
22 11.51 PTGS2 PPARG
23
Show member pathways
11.5 CCNE1 CCND1
24 11.47 TERT CCND1
25
Show member pathways
11.44 PTGS2 CCND1
26 11.4 PTGS2 PPARG
27 11.4 PTGS2 CCNE1 CCND1
28 11.38 PPARG CCNE1
29 11.35 PPARG CCND1
30 11.33 PTGS2 CCND1
31 11.32 CCNE1 CCND1
32 11.24 CCNE1 CCND1
33 11.07 CCNE1 CCND1
34 10.84 CDKN2A CCNE1 CCND1

GO Terms for Bowenoid Papulosis

Cellular components related to Bowenoid Papulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CCNE1 CCND1

Biological processes related to Bowenoid Papulosis according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.73 PTGS2 PPARG CDKN2A
2 positive regulation of apoptotic process GO:0043065 9.67 PTGS2 PPARG CDKN2A
3 response to drug GO:0042493 9.58 PTGS2 PPARG CCND1
4 regulation of protein stability GO:0031647 9.57 TERT CDKN2A
5 response to glucocorticoid GO:0051384 9.55 PTGS2 CCND1
6 response to estrogen GO:0043627 9.54 PPARG CCND1
7 regulation of blood pressure GO:0008217 9.52 PTGS2 PPARG
8 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 9.48 CCNE1 CCND1
9 telomere maintenance GO:0000723 9.46 TERT CCNE1
10 animal organ regeneration GO:0031100 9.43 PPARG CCND1
11 positive regulation of G1/S transition of mitotic cell cycle GO:1900087 9.37 TERT CCND1
12 response to organic cyclic compound GO:0014070 9.33 PTGS2 PPARG CCND1
13 response to organonitrogen compound GO:0010243 9.32 PTGS2 CCND1
14 replicative senescence GO:0090399 9.26 TERT CDKN2A
15 positive regulation of cell cycle GO:0045787 9.21 CCND1
16 response to organic substance GO:0010033 9.13 PTGS2 PPARG CCND1
17 G1/S transition of mitotic cell cycle GO:0000082 8.8 CDKN2A CCNE1 CCND1

Molecular functions related to Bowenoid Papulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.33 PTGS2 PPARG CCND1
2 transcription factor binding GO:0008134 9.13 PPARG CDKN2A CCND1
3 cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 8.62 CCNE1 CCND1

Sources for Bowenoid Papulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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