BP
MCID: BWN003
MIFTS: 33

Bowenoid Papulosis (BP)

Categories: Rare diseases, Reproductive diseases

Aliases & Classifications for Bowenoid Papulosis

MalaCards integrated aliases for Bowenoid Papulosis:

Name: Bowenoid Papulosis 20 71
Bp 20

Classifications:



External Ids:

UMLS 71 C0334106

Summaries for Bowenoid Papulosis

MalaCards based summary : Bowenoid Papulosis, also known as bp, is related to in situ carcinoma and cervical intraepithelial neoplasia. An important gene associated with Bowenoid Papulosis is PPARG (Peroxisome Proliferator Activated Receptor Gamma), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Endometrial cancer. Affiliated tissues include cervix, skin and tongue, and related phenotypes are cellular and endocrine/exocrine gland

Wikipedia : 74 Bowenoid papulosis is a cutaneous condition characterized by the presence of pigmented verrucous papules... more...

Related Diseases for Bowenoid Papulosis

Diseases related to Bowenoid Papulosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 in situ carcinoma 30.6 CDKN2A CCND1
2 cervical intraepithelial neoplasia 30.3 TERT CDKN2A
3 papilloma 30.1 PTGS2 FLG CDKN2A CCND1
4 human papillomavirus infectious disease 29.6 TERT FLG CDKN2A
5 skin carcinoma 28.8 TERT PTGS2 FLG CDKN2A CCND1
6 bowen's disease 10.8
7 squamous cell papilloma 10.6
8 suppressor of tumorigenicity 3 10.4
9 immune deficiency disease 10.4
10 anogenital venereal wart 10.4
11 acquired immunodeficiency syndrome 10.4
12 erythroplakia 10.4
13 cervix uteri carcinoma in situ 10.3
14 lichen planus 10.3
15 vulvar intraepithelial neoplasia 10.3
16 keratosis, seborrheic 10.2
17 epidermodysplasia verruciformis 1 10.2
18 keratosis 10.2
19 inverted follicular keratosis 10.2
20 keratocystic odontogenic tumor 10.1 PTGS2 CCND1
21 skin papilloma 10.1 PTGS2 CCND1
22 systemic lupus erythematosus 10.1
23 dermatitis, atopic 10.1
24 angiosarcoma 10.1
25 pancytopenia 10.1
26 candidiasis 10.1
27 vulvar disease 10.1
28 hairy cell leukemia 10.1
29 focal epithelial hyperplasia 10.1
30 t-cell adult acute lymphocytic leukemia 10.1
31 lymphopenia 10.1
32 skin carcinoma in situ 10.1
33 lupus erythematosus 10.1
34 hypereosinophilic syndrome 10.1
35 leukoplakia 10.1
36 lymphangiectasis 10.1
37 peptic ulcer disease 10.0 PTGS2 PPARG
38 colonic benign neoplasm 10.0 PTGS2 CCND1
39 differentiated thyroid carcinoma 10.0 TERT PPARG
40 chronic leukemia 10.0 PTGS2 CCND1
41 clear cell adenocarcinoma of the ovary 10.0 CCNE1 CCND1
42 parathyroid carcinoma 10.0 TERT CCND1
43 cecal benign neoplasm 9.9 TERT CDKN2A
44 cecum adenoma 9.9 TERT CDKN2A
45 ovarian clear cell carcinoma 9.9 TERT CCNE1
46 spitzoid melanoma 9.9 TERT CDKN2A
47 esophagus verrucous carcinoma 9.9 CDKN2A CCND1
48 verrucous carcinoma 9.9 CDKN2A CCND1
49 barrett's adenocarcinoma 9.9 PTGS2 CDKN2A
50 lymphangioma 9.9 PTGS2 CCND1

Graphical network of the top 20 diseases related to Bowenoid Papulosis:



Diseases related to Bowenoid Papulosis

Symptoms & Phenotypes for Bowenoid Papulosis

MGI Mouse Phenotypes related to Bowenoid Papulosis:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.97 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
2 endocrine/exocrine gland MP:0005379 9.93 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
3 hematopoietic system MP:0005397 9.91 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
4 digestive/alimentary MP:0005381 9.88 CCND1 CCNE1 CDKN2A PTGS2 TERT
5 immune system MP:0005387 9.88 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
6 neoplasm MP:0002006 9.8 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
7 integument MP:0010771 9.77 CCND1 CCNE1 CDKN2A PPARG PTGS2
8 nervous system MP:0003631 9.73 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
9 normal MP:0002873 9.55 CCND1 CCNE1 PPARG PTGS2 TERT
10 reproductive system MP:0005389 9.43 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT
11 skeleton MP:0005390 9.1 CCND1 CCNE1 CDKN2A PPARG PTGS2 TERT

Drugs & Therapeutics for Bowenoid Papulosis

Search Clinical Trials , NIH Clinical Center for Bowenoid Papulosis

Genetic Tests for Bowenoid Papulosis

Anatomical Context for Bowenoid Papulosis

MalaCards organs/tissues related to Bowenoid Papulosis:

40
Cervix, Skin, Tongue

Publications for Bowenoid Papulosis

Articles related to Bowenoid Papulosis:

(show top 50) (show all 313)
# Title Authors PMID Year
1
The prevalence of human leucocyte antigen and human papillomavirus DNA in penile intraepithelial neoplasia in England 2011-2012. 61
33576716 2021
2
[Update on precursors of vulvar carcinoma]. 61
33166702 2020
3
Dihydroartemisinin administration improves the effectiveness of 5-aminolevulinic acid-mediated photodynamic therapy for the treatment of high-risk human papillomavirus infection. 61
33157332 2020
4
Challenge of reflectance confocal microscopy in the diagnosis of genital warts. 61
33053543 2020
5
Reflectance Confocal Microscopy of Pigmented Bowen's Disease: A Case Series of Difficult to Diagnose Lesions. 61
32518541 2020
6
A case of bowenoid papulosis treated with sequential curettage and photodynamic therapy. 61
32052495 2020
7
Distinguishing bowenoid papulosis from Bowen disease in the mouth: A case report. 61
31568562 2020
8
Therapeutic evaluation of 5-aminolevulinic acid-mediated photodynamic therapy in Bowenoid papulosis. 61
31870900 2020
9
Linear Bowenoid Papulosis. 61
31563264 2020
10
Efficacy and Tolerability of Topical Polyphenon E in Multiple "Seborrheic Keratosis-Like" Lesions of the Groin in an Immunocompetent 26-Year-Old Man. 61
31824278 2019
11
Dermatoscopic findings of penile intraepithelial neoplasia: Bowenoid papulosis, Bowen disease and erythroplasia of Queyrat. 61
30585302 2019
12
Premalignant male genital dermatoses. 61
31922098 2019
13
In situ squamous cell carcinoma of male and female external genitalia. 61
31922109 2019
14
Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region. 61
30203987 2019
15
Human papillomavirus 34 associated with bowenoid papulosis of the penile shaft. 61
30570779 2019
16
Epidermal mast cells in Bowenoid papulosis during topical imiquimod therapy. 61
30204264 2019
17
Bowenoid papulosis unveiling a rare cause of immunosuppression. 61
30999833 2019
18
Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands. 61
30508877 2019
19
Oral bowenoid papulosis. 61
30566561 2018
20
[Penile intra-epithelial neoplasia]. 61
29937064 2018
21
Genital bowenoid papulosis: the variegated dermoscopic features. 61
29767494 2018
22
Linear ectopic sebaceous hyperplasia of the penis: the last memory of Tyson's glands. 61
27598618 2018
23
Urologic Dermatology: a Review. 61
28667573 2017
24
Vulvar Bowenoid Papulosis: Histologically High-Grade Squamous Intraepithelial Lesion Known to Spontaneously Regress. 61
28452867 2017
25
[HPV-induced penile intra-epithelial neoplasia: Bowenoid papulosis]. 61
28117082 2017
26
Bowenoid papulosis in a linear distribution. 61
27279825 2016
27
Presentation of epidermolytic acanthomas as multiple tan papules on the vulva. 61
27034569 2016
28
Cutaneous squamous cell carcinoma progression is associated with decreased GATA-3 immunohistochemical staining. 61
26762870 2016
29
High-grade squamous intraepithelial lesion of the oral commissure (bowenoid papulosis). A case and review. 61
26693089 2015
30
Bowenoid papulosis. 61
26692627 2015
31
Seborrheic keratosis with bowenoid transformation: the immunohistochemical features and its association with human papillomavirus infection. 61
25747812 2015
32
Traumatic neuroma of the penis after circumcision--Case report. 61
26131873 2015
33
Aminolevulinic acid photodynamic therapy for bowenoid papulosis. 61
25751357 2015
34
[Actinic keratosis, Bowen's disease, keratoacanthoma and squamous cell carcinoma of the skin]. 61
25663185 2015
35
Detection of human papillomavirus (HPV) in patients with squamous cell carcinoma and the clinical characteristics of HPV-positive cases. 61
24980205 2014
36
Dermoscopic findings in bowenoid papulosis: report of two cases. 61
25396088 2014
37
Dramatic clearance of HIV-associated bowenoid papulosis using combined oral acitretin and topical 5% imiquimod. 61
25116965 2014
38
A case of isolated bowenoid papulosis of the nipple. 61
24966640 2014
39
Bowenoid papulosis successfully treated with imiquimod 5% cream. 61
24909216 2014
40
Pigmented Bowen's disease of the penis and scrotum in a patient with AIDS. 61
24746300 2014
41
Pigmented condyloma acuminatum. 61
24611994 2014
42
[Evaluation of hypnosis in pain management during photodynamic therapy: a pilot study]. 61
24635951 2014
43
Cutaneous human papillomavirus infection: manifestations and diagnosis. 61
24643180 2014
44
Periungual bowenoid papulosis due to human papillomavirus type 42. 61
23375694 2013
45
Extensive bowenoid papulosis of the vulva treated by carbon dioxide laser in a patient with AIDS. 61
23347880 2013
46
Expression of p16 protein in lesional and perilesional condyloma acuminata and bowenoid papulosis: clinical significance and diagnostic implications. 61
23706650 2013
47
Expression of activation-induced cytidine deaminase in Bowenoid papulosis. 61
24126385 2013
48
Anogenital malignancies and premalignancies: facts and controversies. 61
23806153 2013
49
[Precancerous tumors and carcinomas in situ of the skin]. 61
23657620 2013
50
Spontaneous regression of bowenoid papulosis. 61
24011282 2013

Variations for Bowenoid Papulosis

Expression for Bowenoid Papulosis

Search GEO for disease gene expression data for Bowenoid Papulosis.

Pathways for Bowenoid Papulosis

Pathways related to Bowenoid Papulosis according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.63 TERT PTGS2 CCNE1 CCND1
2
Show member pathways
12.48 PPARG CDKN2A CCNE1 CCND1
3
Show member pathways
12.42 CDKN2A CCNE1 CCND1
4
Show member pathways
12.37 TERT CDKN2A CCNE1 CCND1
5
Show member pathways
12.29 CDKN2A CCNE1 CCND1
6 12.23 CDKN2A CCNE1 CCND1
7 12.15 PTGS2 CCNE1 CCND1
8
Show member pathways
12.1 CDKN2A CCNE1 CCND1
9 12.08 CDKN2A CCNE1 CCND1
10
Show member pathways
12.06 CDKN2A CCNE1 CCND1
11 12.05 PTGS2 CDKN2A CCNE1 CCND1
12
Show member pathways
12.02 PTGS2 PPARG CCND1
13 12 CDKN2A CCNE1 CCND1
14
Show member pathways
11.9 CDKN2A CCNE1 CCND1
15 11.83 CDKN2A CCNE1 CCND1
16 11.83 TERT PTGS2 PPARG CDKN2A CCNE1 CCND1
17 11.6 TERT CDKN2A CCNE1 CCND1
18 11.59 CDKN2A CCNE1 CCND1
19
Show member pathways
11.55 CCNE1 CCND1
20 11.47 TERT CCND1
21 11.46 PTGS2 CCNE1 CCND1
22
Show member pathways
11.44 PTGS2 CCND1
23 11.4 PTGS2 PPARG
24 11.38 PPARG CCNE1
25 11.34 PPARG CCND1
26 11.32 PTGS2 CCND1
27 11.3 CCNE1 CCND1
28 11.23 CCNE1 CCND1
29 11.07 CCNE1 CCND1
30 11.04 CDKN2A CCNE1 CCND1

GO Terms for Bowenoid Papulosis

Cellular components related to Bowenoid Papulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.5 TERT PTGS2 PPARG FLG CDKN2A CCNE1
2 cyclin-dependent protein kinase holoenzyme complex GO:0000307 8.62 CCNE1 CCND1

Biological processes related to Bowenoid Papulosis according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.69 PTGS2 PPARG CDKN2A
2 response to drug GO:0042493 9.61 PTGS2 PPARG CCND1
3 regulation of blood pressure GO:0008217 9.56 PTGS2 PPARG
4 response to glucocorticoid GO:0051384 9.55 PTGS2 CCND1
5 response to estrogen GO:0043627 9.54 PPARG CCND1
6 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000079 9.52 CCNE1 CCND1
7 telomere maintenance GO:0000723 9.49 TERT CCNE1
8 animal organ regeneration GO:0031100 9.48 PPARG CCND1
9 positive regulation of G1/S transition of mitotic cell cycle GO:1900087 9.46 TERT CCND1
10 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.4 TERT PPARG
11 response to organonitrogen compound GO:0010243 9.37 PTGS2 CCND1
12 response to organic cyclic compound GO:0014070 9.33 PTGS2 PPARG CCND1
13 mitotic cell cycle phase transition GO:0044772 9.32 CCNE1 CCND1
14 replicative senescence GO:0090399 9.26 TERT CDKN2A
15 G1/S transition of mitotic cell cycle GO:0000082 9.13 CDKN2A CCNE1 CCND1
16 response to organic substance GO:0010033 8.8 PTGS2 PPARG CCND1

Molecular functions related to Bowenoid Papulosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.33 PTGS2 PPARG CCND1
2 transcription factor binding GO:0008134 9.13 PPARG CDKN2A CCND1
3 cyclin-dependent protein serine/threonine kinase regulator activity GO:0016538 8.62 CCNE1 CCND1

Sources for Bowenoid Papulosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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