MCID: BWN006
MIFTS: 32

Bowen's Disease

Categories: Rare diseases

Aliases & Classifications for Bowen's Disease

MalaCards integrated aliases for Bowen's Disease:

Name: Bowen's Disease 20 70
Bowens Disease 54

Classifications:



External Ids:

UMLS 70 C0006079

Summaries for Bowen's Disease

MalaCards based summary : Bowen's Disease, also known as bowens disease, is related to porokeratosis and keratosis. An important gene associated with Bowen's Disease is PCNA (Proliferating Cell Nuclear Antigen), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Fluorouracil and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, cervix and eye.

Related Diseases for Bowen's Disease

Diseases related to Bowen's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 191)
# Related Disease Score Top Affiliating Genes
1 porokeratosis 31.5 KRT16 IVL
2 keratosis 30.6 KRT16 KRT10 IVL
3 borst-jadassohn intraepidermal carcinoma 30.5 KRT7 KRT16 KRT10 IVL
4 squamous cell carcinoma 30.5 MKI67 KRT7 IVL
5 leukoplakia 30.4 PCNA MKI67
6 keratosis, seborrheic 30.1 KRT7 KRT10 IVL
7 eccrine acrospiroma 30.0 KRT7 KRT10
8 skin carcinoma 29.9 KRT7 KRT10 IVL
9 cervical intraepithelial neoplasia 29.8 MKI67 IVL
10 clear cell acanthoma 29.8 KRT10 IVL
11 papilloma 29.8 PCNA KRT7 KRT10 IVL
12 palmoplantar keratosis 29.7 KRT16 KRT10
13 skin disease 29.7 KRT16 KRT10 IVL
14 psoriasis 29.6 KRT16 KRT10 IVL
15 basal cell carcinoma 29.5 MKI67 KRT7 KRT16 KRT10 IVL
16 large cell acanthoma 29.5 KRT7 KRT10
17 keratoacanthoma 29.4 MKI67 KRT16 KRT10 IVL
18 lichen planus 29.4 KRT16 KRT10 IVL
19 epidermolysis bullosa 29.1 KRT16 KRT10 IVL
20 penis carcinoma in situ 11.4
21 in situ carcinoma 10.8
22 actinic keratosis 10.7
23 bowenoid papulosis 10.6
24 mammary paget's disease 10.6
25 squamous cell papilloma 10.5
26 inverted follicular keratosis 10.5
27 erythroplakia 10.4
28 epidermodysplasia verruciformis 1 10.4
29 merkel cell carcinoma 10.3
30 melanoma 10.3
31 superficial basal cell carcinoma 10.3
32 pustulosis of palm and sole 10.3
33 eccrine porocarcinoma 10.3
34 superficial spreading melanoma 10.3
35 vulvar intraepithelial neoplasia 10.2
36 dowling-degos disease 1 10.2
37 mycosis fungoides 10.2
38 pigmented basal cell carcinoma 10.2
39 sebaceous adenocarcinoma 10.1
40 intracranial meningioma 10.1 PCNA MKI67
41 oral leukoplakia 10.1 PCNA MKI67
42 porokeratosis 1, multiple types 10.1
43 suppressor of tumorigenicity 3 10.1
44 common wart 10.1
45 anogenital venereal wart 10.1
46 neuroendocrine carcinoma 10.1
47 benign meningioma 10.1 PCNA MKI67
48 necrotizing sialometaplasia 10.0 MKI67 KRT7
49 irritant dermatitis 10.0 KRT16 IVL
50 mature teratoma 10.0 PCNA KRT7

Graphical network of the top 20 diseases related to Bowen's Disease:



Diseases related to Bowen's Disease

Symptoms & Phenotypes for Bowen's Disease

Drugs & Therapeutics for Bowen's Disease

Drugs for Bowen's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 4 51-21-8 3385
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3 Immunologic Factors Phase 4
4 Anesthetics Phase 4
5 Immunosuppressive Agents Phase 4
6 Antimetabolites Phase 4
7
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
8
Aminolevulinic acid Approved Phase 3 106-60-5 137
9 Adjuvants, Immunologic Phase 2, Phase 3
10 interferons Phase 2, Phase 3
11 Methyl 5-aminolevulinate Phase 3
12 Dermatologic Agents Phase 3
13
Petrolatum Approved, Investigational Phase 2 8009-03-8
14
Prilocaine Approved Phase 1 721-50-6 4906
15
Protoporphyrin IX Experimental Phase 1 553-12-8
16 Anti-Arrhythmia Agents Phase 1
17 Sodium Channel Blockers Phase 1
18 Diuretics, Potassium Sparing Phase 1
19 Anesthetics, Local Phase 1
20 Lidocaine, Prilocaine Drug Combination Phase 1
21
Epinephrine Approved, Vet_approved 51-43-4 5816
22
Racepinephrine Approved 329-65-7 838
23
Ethanol Approved 64-17-5 702
24 Respiratory System Agents
25 Adrenergic alpha-Agonists
26 Anti-Asthmatic Agents
27 Adrenergic beta-Agonists
28 Epinephryl borate
29 Adrenergic Agonists
30 Adrenergic Agents
31 Mydriatics
32 Sympathomimetics
33 Neurotransmitter Agents
34 Bronchodilator Agents
35 Vasoconstrictor Agents
36 Pharmaceutical Solutions
37 Photosensitizing Agents

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Surgical Excision Versus Photodynamic Therapy and Topical 5-fluorouracil in Treatment of Bowen's Disease: a Multicenter Randomized Controlled Trial Recruiting NCT03909646 Phase 4 Methyl Aminolevulinate (Mal) for Topical Administration, 16.8%, 1 Gram;5Fluorouracil
2 A Randomized Clinical Trial of Excision Versus Photodynamic Therapy in Bowen's Disease Terminated NCT00472706 Phase 4
3 Phase III Trial of 6 Weeks of Imiquimod for the Treatment of Bowens Disease of the Head and Neck. Outcome is Histologic Clearance at 14 Weeks. Unknown status NCT00384124 Phase 2, Phase 3 Imiquimod
4 A Multicentre, Randomised Study of Photodynamic Therapy(PDT) With Metvix® 160 mg/g Cream in Immuno-compromised Patients With Non-melanoma Skin Cancer Completed NCT00472459 Phase 3
5 Identification of Compound From Brinjal Peel Extract That is Effective in the Treatment of Severe Palmar Arsenical Keratosis and Bowen's Disease Unknown status NCT03641079 Phase 2 Brinjal peel extract containing cream
6 An Open Label, Dose Escalation Study to Evaluate the Safety and Efficacy of Intralesional Injection of STP705 in Adult Patients With Cutaneous Squamous Cell Carcinoma in Situ (isSCC) Completed NCT04293679 Phase 1, Phase 2 STP705
7 An Open Phase II Study to Assess the Efficacy and Safety of Topical SR-T100® Gel in the Treatment of Human Cutaneous Squamous Cell Carcinoma in Situ (Actinic Keratosis and Bowen's Disease) Completed NCT02085395 Phase 2 SR-T100 ® Gel
8 Multi-centre, Open-label Study to Determine the Safety and Efficacy of PEP005 0.05% Topical Gel in Patients With Cutaneous Squamous Cell Carcinoma In Situ (SCCIS, Bowen's Disease) Completed NCT00329121 Phase 2 PEP005
9 A Randomized, Intra-individual, Prospective Study Comparing Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Ablative Fractional Laser Treatment in Asian Patients With Lower Extremity Bowen's Disease Completed NCT01912976 Phase 1 Er:YAG AFL-PDT;MAL-PDT
10 Long-term Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy for Treatment of Lower Extremity Bowen's Disease: A Prospective, Randomized, Controlled Trial With 5-year Follow up Completed NCT03320447 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
11 Effects of Arsenic on Keratinocytes in a Skin Equivalent Model Unknown status NCT00166946
12 A Randomized Controlled Trial of a Full and a Fractional Ablative Carbon Dioxide Laser as Pretreatment for Photodynamic Therapy in the Management of Superficial Non Melanoma Skin Cancer Completed NCT03012009 MAL;lidocaine hydrochloride 2% with epinephrine
13 Using a Cold Atmospheric Plasma Device to Treat Skin Disorders Recruiting NCT02759900
14 Fluorescence and Thermal Imaging of the Skin Before and During Photodynamic Therapy Active, not recruiting NCT03167762
15 Compassionate Use of Metvix® (Methyl Aminolevulinate) PDT in Subjects With Field Actinic Keratoses, Large/Multiple Superficial BCCs, or Bowen's Disease No longer available NCT00535080 Metvix (methyl aminolevulinate)

Search NIH Clinical Center for Bowen's Disease

Genetic Tests for Bowen's Disease

Anatomical Context for Bowen's Disease

MalaCards organs/tissues related to Bowen's Disease:

40
Skin, Cervix, Eye, Breast, Colon, Endothelial, Tongue

Publications for Bowen's Disease

Articles related to Bowen's Disease:

(show top 50) (show all 1863)
# Title Authors PMID Year
1
Expression of minichromosome maintenance 5 protein in proliferative and malignant skin diseases. 61 54
17988337 2007
2
Expression of cytokeratin subtypes in intraepidermal malignancies: a guide for differentiation. 61 54
16919026 2006
3
The characteristics of human papillomavirus expression and cell proliferation in actinic keratosis and Bowen's disease of the skin. 54 61
16905862 2006
4
Human papillomavirus infection in actinic keratosis and bowen's disease: comparative study with expression of cell-cycle regulatory proteins p21(Waf1/Cip1), p53, PCNA, Ki-67, and Bcl-2 in positive and negative lesions. 61 54
14562284 2003
5
An assessment of the malignant potential of actinic keratoses and Bowen's disease: p53 and PCNA expression pattern correlate with the number of desmosomes. 54 61
12392064 2002
6
Abnormal immunoreactivity of the E-cadherin/catenin (alpha-, beta-, and gamma-) complex in premalignant and malignant non-melanocytic skin tumours. 61 54
11793366 2002
7
Patterns of basal cell keratin 14 expression in Bowen's disease: a possible marker for tumour progression. 61 54
11531783 2001
8
Comparative histochemical study of Bowen's disease and actinic keratosis: preserved normal basal cells in Bowen's disease. 54 61
11512639 2001
9
Expression of desmoglein I and plakoglobin in skin carcinomas. 54 61
10660128 2000
10
In situ localization of S-phase-specific histone (H3) mRNA in Bowen's disease. 61 54
10598872 1999
11
Expression of cell-cycle proteins p53, p21 (WAF-1), PCNA and Ki-67 in benign, premalignant and malignant skin lesions with implicated HPV involvement. 61 54
10429981 1999
12
Histopathological assessment of localized proliferation in cases of Bowen's disease using immunostaining and a laser cytometer. 54 61
9763306 1998
13
Immunohistochemical demonstration of carcinoembryonic antigen and related antigens in various cutaneous keratinous neoplasms and verruca vulgaris. 54 61
9767229 1998
14
The proliferative properties of tumor cells differentially correlate with the host immune responses in anogenital Bowen's disease. 61 54
10342748 1998
15
Expression of proliferating cell nuclear antigen (PCNA) and apoptosis related antigen (LeY) in epithelial skin tumors. 54 61
9557786 1998
16
Perianal Bowen's disease: a clinicopathologic study of 47 patients. 54 61
9369101 1997
17
Dysregulated expression of transforming growth factor beta and its type-I and type-II receptors in basal-cell carcinoma. 54 61
9178800 1997
18
Proliferating cell nuclear antigen (PCNA) expression in pseudoepitheliomatous hyperplasia, keratoacanthoma and squamous cell carcinoma of the skin. 61 54
8893923 1996
19
Immunohistochemical localization of keratins and involucrin in solar keratosis and Bowen's disease. 61 54
8600780 1995
20
Proliferating cell nuclear antigen (PCNA) and p53 protein expression in Bowen's disease. 61 54
7868767 1994
21
Expression of proliferation-associated proteins (proliferating cell nuclear antigen and Ki-67 antigen) in Bowen's disease. 61 54
7917988 1994
22
Ki-67 and p53 expression in cutaneous Bowen's disease: an immunohistochemical study of fixed-embedded tissue sections. 54 61
7911636 1994
23
Progressive alterations of cytokeratin expressions in the process of chronic arsenism. 54 61
7509818 1993
24
[Expression of keratin 16 in normal and lesional skin of solitary and multiple Bowen's disease using monoclonal antibody Ks 8.12 staining]. 61 54
1724782 1991
25
Human papillomavirus infection and filaggrin expression in paraffin-embedded biopsy specimens of extragenital Bowen's disease and genital bowenoid papulosis. 54 61
2164515 1990
26
The prevalence of human leucocyte antigen and human papillomavirus DNA in penile intraepithelial neoplasia in England 2011-2012. 61
33576716 2021
27
Invasive and in situ lesions of squamous cell carcinoma are independent factors for postoperative surgical-site infection after outpatient skin tumors surgery: A retrospective study of 512 patients. 61
33560553 2021
28
Review of the European Society for Photodynamic Therapy (Euro-PDT) Annual Congress 2020. 61
33648910 2021
29
A case of perianal bowenoid papulosis: dermoscopic features and a review of previous cases. 61
33765757 2021
30
Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7. 61
32867548 2021
31
High-frequency ultrasound in the diagnosis of the spectrum of cutaneous squamous cell carcinoma: Noninvasively distinguishing actinic keratosis, Bowen's Disease, and invasive squamous cell carcinoma. 61
33751714 2021
32
The diagnostic value of p63, p16, and p53 immunohistochemistry in distinguishing seborrheic keratosis, actinic keratosis, and Bowen's disease. 61
33497503 2021
33
Screening for Melanoma and Other Skin Cancer Shows a Higher Early Melanoma Incidence: Social Educational Program "Life Fear-Free". 61
33803969 2021
34
Pigmented Bowen's disease on the finger mimicking malignant melanoma: A dermoscopic pitfall. 61
33769743 2021
35
Pigmented Bowen's disease on the proximal nail fold with extensive, parallel pigmented lines in dermoscopy. 61
33227144 2021
36
Superficial CD34-positive Fibroblastic Tumour: Unique Subungual Presentation with Confounding Clinical Findings Resembling Fibrokeratoma-like Bowen's Disease. 61
33320273 2021
37
Lichen Sclerosus and Phimosis - Discrepancies Between Clinical and Pathological Diagnosis and Its Consequences. 61
33248142 2021
38
Dermatoscopic findings and dermatopathological correlates in clinical variants of actinic keratosis, Bowen's disease, keratoacanthoma, and squamous cell carcinoma. 61
33583118 2021
39
Cutaneous Squamous Cell Carcinoma: From Pathophysiology to Novel Therapeutic Approaches. 61
33572373 2021
40
Verrucous Bowen's disease on the hand successfully treated with prolonged course of topical 5% 5-fluorouracil. 61
33258540 2021
41
Skin cancers in people with albinism in Togo in 2019: results of two rounds of national mobile skin care clinics. 61
33402100 2021
42
[Photodynamic therapy-trends and new developments]. 61
33301063 2021
43
The diagnostic value of in vivo reflectance confocal microscopy in actinic keratosis. 61
32696993 2021
44
Mucosal side effects in patients treated with topical imiquimod-A scoping review of the literature. 61
32990395 2021
45
Whole-exome sequencing and host cell reactivation assay lead to a diagnosis of xeroderma pigmentosum group D with mild ultraviolet radiation sensitivity. 61
32974964 2021
46
Laser Treatment for Non-Melanoma Skin Cancer: A Systematic Review and Meta-Analysis. 61
32930983 2021
47
Nanocarriers for Photodynamic Therapy Intended to Cutaneous Tumors. 61
33397257 2021
48
A case of coexisting Bowen's disease and cutaneous pseudolymphoma. 61
33459265 2020
49
Overlapping tumor-specific expression of p53, p16INK4a, and sirtuin 1 in Bowen's disease: A case report. 61
33363940 2020
50
Efficacy of photodynamic therapy for the treatment of Bowen's disease: An updated systematic review and meta-analysis of randomized controlled trials. 61
33011394 2020

Variations for Bowen's Disease

Expression for Bowen's Disease

Search GEO for disease gene expression data for Bowen's Disease.

Pathways for Bowen's Disease

Pathways related to Bowen's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.67 KRT7 KRT16 KRT10 IVL
2
Show member pathways
11.38 KRT7 KRT16 KRT10 IVL
3
Show member pathways
11.36 KRT7 KRT16
4 11.24 KRT16 KRT10
5 10.82 PCNA MKI67

GO Terms for Bowen's Disease

Cellular components related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 PCNA KRT7 KRT16 KRT10 IVL
2 nuclear body GO:0016604 9.33 PCNA MKI67 IVL
3 cornified envelope GO:0001533 9.26 KRT10 IVL
4 intermediate filament GO:0005882 8.8 KRT7 KRT16 KRT10

Biological processes related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinocyte differentiation GO:0030216 9.33 KRT16 KRT10 IVL
2 peptide cross-linking GO:0018149 9.26 KRT10 IVL
3 keratinization GO:0031424 9.26 KRT7 KRT16 KRT10 IVL
4 cornification GO:0070268 8.92 KRT7 KRT16 KRT10 IVL

Sources for Bowen's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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