MCID: BWN006
MIFTS: 39

Bowen's Disease

Categories: Rare diseases

Aliases & Classifications for Bowen's Disease

MalaCards integrated aliases for Bowen's Disease:

Name: Bowen's Disease 54 74
Bowens Disease 56

Classifications:



External Ids:

UMLS 74 C0006079

Summaries for Bowen's Disease

MalaCards based summary : Bowen's Disease, also known as bowens disease, is related to actinic keratosis and leukoplakia. An important gene associated with Bowen's Disease is PCNA (Proliferating Cell Nuclear Antigen), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs Mycophenolic acid and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and prostate.

Wikipedia : 77 Bowen''s disease, also known as squamous cell carcinoma in situ is a neoplastic skin disease. It can be... more...

Related Diseases for Bowen's Disease

Diseases related to Bowen's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 actinic keratosis 30.8 KRT17 PCNA
2 leukoplakia 30.2 MKI67 PCNA
3 basal cell carcinoma 30.0 KRT10 KRT17 KRT7
4 psoriasis 30.0 KRT16 KRT17
5 eccrine acrospiroma 29.9 KRT10 KRT17
6 acanthoma 29.9 KRT10 KRT17
7 papilloma 29.8 KRT10 KRT7 PCNA
8 keratosis, seborrheic 29.7 KRT10 KRT17
9 vulvar intraepithelial neoplasia 29.5 KRT10 KRT7
10 keratoacanthoma 29.2 KRT10 KRT16 KRT17 MKI67
11 large cell acanthoma 29.1 KRT10 KRT17 KRT7
12 penis carcinoma in situ 11.5
13 borst-jadassohn intraepidermal carcinoma 11.2
14 squamous cell carcinoma 10.8
15 keratosis 10.6
16 in situ carcinoma 10.6
17 melanoma 10.5
18 basal cell carcinoma 1 10.5
19 bowenoid papulosis 10.4
20 mammary paget's disease 10.3
21 merkel cell carcinoma 10.3
22 epidermodysplasia verruciformis 1 10.2
23 porokeratosis 10.2
24 erythroplakia 10.2
25 oral leukoplakia 10.2 MKI67 PCNA
26 benign meningioma 10.2 MKI67 PCNA
27 superficial basal cell carcinoma 10.2
28 paget disease, extramammary 10.1
29 meningioma, radiation-induced 10.1 MKI67 PCNA
30 leukemia 10.1
31 squamous cell papilloma 10.1
32 palmoplantar keratoderma, bothnian type 10.1 KRT16 KRT17
33 tinea corporis 10.1 KRT16 KRT17
34 median rhomboid glossitis 10.1 KRT16 KRT17
35 cervical intraepithelial neoplasia 10.1 KRT17 MKI67
36 necrotizing sialometaplasia 10.1 KRT7 MKI67
37 hidradenocarcinoma 10.1 KRT7 MKI67
38 mycosis fungoides 10.0
39 pulmonary alveolar microlithiasis 10.0
40 sebaceous adenocarcinoma 10.0
41 eccrine porocarcinoma 10.0
42 clear cell basal cell carcinoma 10.0 KRT17 KRT7
43 mucinous cystadenocarcinoma 10.0 KRT7 PCNA
44 ampulla of vater adenocarcinoma 10.0 KRT17 KRT7
45 infiltrative basal cell carcinoma 10.0 KRT17 KRT7
46 ovarian mucinous neoplasm 10.0 KRT17 KRT7
47 pregnancy adenoma 10.0 KRT17 KRT7
48 cavernous hemangioma 10.0 KRT7 MKI67
49 basaloid squamous cell carcinoma 10.0 KRT17 KRT7
50 ampulla of vater cancer 10.0 KRT17 KRT7

Graphical network of the top 20 diseases related to Bowen's Disease:



Diseases related to Bowen's Disease

Symptoms & Phenotypes for Bowen's Disease

Drugs & Therapeutics for Bowen's Disease

Drugs for Bowen's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 60)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 4 24280-93-1 446541
2
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
3
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
4
Azathioprine Approved Phase 4 446-86-6 2265
5
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492 6473866
6
Everolimus Approved Phase 4 159351-69-6 6442177 70789204
7 Immunologic Factors Phase 4,Phase 2,Phase 3
8 Anti-Infective Agents Phase 4,Phase 1
9 Anti-Bacterial Agents Phase 4
10 Immunosuppressive Agents Phase 4
11 Antibiotics, Antitubercular Phase 4
12 Cyclosporins Phase 4
13 Antifungal Agents Phase 4
14 Calcineurin Inhibitors Phase 4
15
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
16
Aminolevulinic acid Approved Phase 3,Phase 1,Phase 2,Not Applicable 106-60-5 137
17 Adjuvants, Immunologic Phase 2, Phase 3
18 Interferon Inducers Phase 2, Phase 3
19 interferons Phase 2, Phase 3
20 Methyl 5-aminolevulinate Phase 3,Phase 1,Not Applicable
21 Photosensitizing Agents Phase 3,Phase 1,Phase 2,Not Applicable
22 Dermatologic Agents Phase 3,Phase 1,Phase 2,Not Applicable
23
Ethanol Approved Phase 2 64-17-5 702
24
Petrolatum Approved, Investigational Phase 2 8009-03-8
25 Pharmaceutical Solutions Phase 1, Phase 2
26
Lidocaine Approved, Vet_approved Phase 1,Not Applicable 137-58-6 3676
27
Prilocaine Approved Phase 1 721-50-6 4906
28
Silicon Approved, Investigational Phase 1 7440-21-3 4082203
29
Protoporphyrin IX Experimental Phase 1 553-12-8
30 Anesthetics, Local Phase 1,Not Applicable
31 Anesthetics Phase 1,Not Applicable
32 Sodium Channel Blockers Phase 1,Not Applicable
33 Anti-Arrhythmia Agents Phase 1,Not Applicable
34 Central Nervous System Depressants Phase 1,Not Applicable
35 Peripheral Nervous System Agents Phase 1,Not Applicable
36 Diuretics, Potassium Sparing Phase 1,Not Applicable
37 Lidocaine, Prilocaine Drug Combination Phase 1
38 Antiparasitic Agents Phase 1
39 Micronutrients Phase 1
40 Antiprotozoal Agents Phase 1
41 Antiviral Agents Phase 1
42 Nutrients Phase 1
43 Silicon phthalocyanine Phase 1
44 Antimalarials Phase 1
45 Trace Elements Phase 1
46
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
47
Racepinephrine Approved Not Applicable 329-65-7 838
48 Neurotransmitter Agents Not Applicable
49 Sympathomimetics Not Applicable
50 Anti-Asthmatic Agents Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Trial of Excision Versus Photodynamic Therapy in the Treatment of Bowen's Disease Terminated NCT00472706 Phase 4
2 Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol Terminated NCT01797315 Phase 4 Sirolimus
3 Topical Imiquimod for Bowen's Disease of the Head and Neck Unknown status NCT00384124 Phase 2, Phase 3 Imiquimod
4 PDT With Metvix® 160 mg/g Cream in Organ Transplant Recipients With Non-melanoma Skin Cancer Completed NCT00472459 Phase 3
5 Clinical Study Assessment of SR-T100 Topical Gel Against Actinic Keratosis Completed NCT02085395 Phase 2 SR-T100 ® Gel
6 Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Cutaneous Squamous Cell Carcinoma In Situ Completed NCT00329121 Phase 2 PEP005
7 Identification of Compound From Brinjal Peel Extract in the Treatment of Palmar Arsenical Keratosis and Bowen's Disease Recruiting NCT03641079 Phase 2 Brinjal peel extract containing cream
8 DUSA: Cyclic PDT for the Prevention of AK & NMSC in Solid Organ Transplant Recipients Terminated NCT03110159 Phase 1, Phase 2 Levulan® Kerastick®;BLU-U Blue Light Photodynamic Therapy
9 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Bowen's Disease Completed NCT01912976 Phase 1 Er:YAG AFL-PDT;MAL-PDT
10 Long-term Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy for Treatment of Lower Extremity Bowen's Disease Completed NCT03320447 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
11 Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II Mycosis Fungoides Completed NCT00103246 Phase 1 silicon phthalocyanine 4
12 Effects of Arsenic on Keratinocytes in a Skin Equivalent Model Unknown status NCT00166946 Not Applicable
13 Laser Assisted Drug Delivery in the Treatment of Superficial Non Melanoma Skin Cancer: a Randomized Controlled Trial Completed NCT03012009 Not Applicable MAL;lidocaine hydrochloride 2% with epinephrine
14 Reflectance Confocal Microscopy in Basal Cell Carcinoma Recruiting NCT02623101 Not Applicable
15 Photographing the Skin During Photodynamic Therapy Enrolling by invitation NCT03167762 Not Applicable
16 Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease No longer available NCT00535080 Metvix (methyl aminolevulinate)

Search NIH Clinical Center for Bowen's Disease

Genetic Tests for Bowen's Disease

Anatomical Context for Bowen's Disease

MalaCards organs/tissues related to Bowen's Disease:

42
Skin, Lung, Prostate, Colon, Bone, Breast, Cervix

Publications for Bowen's Disease

Articles related to Bowen's Disease:

(show top 50) (show all 740)
# Title Authors Year
1
High-risk Mucosal Human Papillomavirus Infection in Squamous Cell Carcinoma and Bowen's Disease of the Hand. ( 30653652 )
2019
2
Long-term efficacy of photodynamic therapy with methyl aminolevulinate in treating Bowen's disease in clinical practice: a retrospective cohort study (2006-2017). ( 30690796 )
2019
3
Relationship between dermoscopy and pathology in a case of clonal-type pigmented Bowen's disease: Observation with vertical-view dermoscopy. ( 30768803 )
2019
4
In-transit recurrence of Merkel cell carcinoma associated with Bowen's disease: The first reported case successfully treated by avelumab. ( 30809835 )
2019
5
Successful Treatment for Extensive Bowen's Disease using Daylight-mediated Photodynamic Therapy. ( 30868171 )
2019
6
Giant Bowen's Disease on the Face: Case Report and Review of the Literature. ( 30894921 )
2019
7
Cutaneous Bowen's Disease: an Analysis of 182 Cases according To Age, Sex, and Anatomical Site from an Italian Center. ( 30894936 )
2019
8
Cryosurgery + 5% 5-Fluorouracil for Treatment of Superficial Basal Cell Carcinoma and Bowen's Disease [Formula: see text]. ( 29457484 )
2018
9
Clinical experience of ingenol mebutate gel for the treatment of Bowen's disease. ( 29383745 )
2018
10
Bowen's Disease: Long-term Results of Treatment with 5-Fluorouracil Cream, Photodynamic Therapy or Surgical Excision. ( 29135015 )
2018
11
Accuracy of dermoscopic criteria for the differentiation between superficial basal cell carcinoma and Bowen's disease. ( 29633377 )
2018
12
Ablative fractional laser-assisted photodynamic therapy provides superior long-term efficacy compared to standard methyl aminolevulinate photodynamic therapy for lower extremity Bowen's disease. ( 29857012 )
2018
13
Characterization of centriole duplication in human epidermis, Bowen's disease, and squamous cell carcinoma. ( 29615326 )
2018
14
Differential proteomic analysis of actinic keratosis, Bowen's disease and cutaneous squamous cell carcinoma by label-free LC-MS/MS. ( 29665991 )
2018
15
Epithelial-mesenchymal transition in Bowen's disease when arising de novo and acquiring invasive capacity. ( 29864224 )
2018
16
The role of reflectance confocal microscopy in a case of Bowen's disease difficult to diagnose. ( 29445580 )
2018
17
Laser-assisted photodynamic therapy for superficial basal cell carcinoma and Bowen's Disease: a randomised intra-patient comparison between a continuous and a fractional ablative CO<sub>2</sub> laser mode. ( 29633367 )
2018
18
High-risk human papillomavirus in a child with digital pigmented Bowen's disease: Case report and dermoscopic findings. ( 29931706 )
2018
19
Image Gallery: Bowen's disease of a nail unit presenting with 'woodgrain appearance' - a new dermoscopic finding. ( 29357581 )
2018
20
Cyclin D1 promoter -56 and -54bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen's disease. ( 29103775 )
2018
21
Comparison of oxidative stress on DNA, protein and lipids in patients with actinic keratosis, Bowen's disease and squamous cell carcinoma. ( 30222205 )
2018
22
Merkel cell carcinoma arising on a pre-existing Bowen's disease: is it just by chance? ( 26222729 )
2018
23
Bowen's Disease in Dermoscopy. ( 29989873 )
2018
24
Enhancement of Photodynamic Therapy for Bowen's Disease Using Plum-Blossom Needling to Augment Drug Delivery. ( 29994952 )
2018
25
Identification of a human papillomavirus type 58 lineage in multiple Bowen's disease on the fingers: Case report and published work review. ( 30035309 )
2018
26
Collision tumor: pigmented Bowen's disease and seborrheic keratosis. ( 30156629 )
2018
27
Photodynamic therapy for Bowen's Disease (squamous cell carcinoma in situ) current review and update. ( 30240928 )
2018
28
Bowen's Disease of the Nipple. ( 30323750 )
2018
29
Hypomelanotic melanoma simulating pigmented Bowen's disease and its challenging dermoscopic features. ( 30353916 )
2018
30
On "Multicentric Anogenital Bowen's Disease Treated with Imiquimod and CO2 Laser". ( 30413221 )
2018
31
Multicentric Anogenital Bowen's Disease Treated with Imiquimod and CO2 Laser. ( 30413229 )
2018
32
Acral and Multicentric Pigmented Bowen's Disease in HIV-Positive Patients: Report on Two Unusual Cases. ( 30504981 )
2018
33
Germ line TP53 mutation in a patient with multiple Bowen's disease. ( 30592087 )
2018
34
A Case Series of Bowen's Disease Treated with the Combination of Cryosurgery and Ingenol Mebutate and Followed Up with Optical Coherence Tomography. ( 30643651 )
2018
35
Effectiveness of photodynamic therapy in refractory plaque-stage mycosis fungoides associated with Bowen's disease. ( 28198112 )
2017
36
A case of pigmented Bowen's disease. ( 28225972 )
2017
37
Lobulated Bowen's Disease with a Clear Cell Change. ( 28761300 )
2017
38
Pigmented Bowen's disease associated with high-risk HPV simulating melanoma of the hand. ( 29166507 )
2017
39
Trial of hyperthermic treatment for Bowen's disease with disposable chemical pocket warmers: A report of two cases. ( 29239019 )
2017
40
A Case of Pagetoid Bowen's Disease. ( 29237947 )
2017
41
A Case of Bowen's Disease Successfully Treated with Ingenol Mebutate Gel. ( 28761314 )
2017
42
Phasor-FLIM as a Screening Tool for the Differential Diagnosis of Actinic Keratosis, Bowen's Disease, and Basal Cell Carcinoma. ( 28661125 )
2017
43
What's new in dermoscopy of Bowen's disease: two new dermoscopic signs and its differential diagnosis. ( 28832993 )
2017
44
Giant neglected Bowen's disease lesion treated successfully with topical 5-fluorouracil. ( 28752147 )
2017
45
p16 immunostaining in keratinocytic neoplasia in organ transplant recipients: Bowen's disease shows a characteristic pattern. ( 27717097 )
2017
46
Bowen's disease: Two case reports of a giant and dwarf lesions. ( 28643763 )
2017
47
Clinical, histological and therapeutic features of Bowen's disease. ( 28523295 )
2017
48
Reflectance confocal microscopy of Pigmented Bowen's disease: misleading dendritic cells. ( 27430726 )
2017
49
Polydactylous Bowen's Disease in an Immunocompromised Patient: Resolution of All Lesions After Mohs Surgery on a Single Lesion. ( 28930791 )
2017
50
Bowen's Disease Associated With Two Human Papilloma Virus Types. ( 29202554 )
2017

Variations for Bowen's Disease

Expression for Bowen's Disease

Search GEO for disease gene expression data for Bowen's Disease.

Pathways for Bowen's Disease

Pathways related to Bowen's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 KRT10 KRT16 KRT17 KRT7
2 11.82 KRT10 KRT17 KRT7
3
Show member pathways
11.38 KRT10 KRT16 KRT17 KRT7
4
Show member pathways
11.17 KRT16 KRT17 KRT7
5 11.13 MKI67 PCNA

GO Terms for Bowen's Disease

Cellular components related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 KRT10 KRT16 KRT17 KRT7 PCNA
2 intermediate filament GO:0005882 8.92 KRT10 KRT16 KRT17 KRT7

Biological processes related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.33 KRT16 MKI67 PCNA
2 epidermis development GO:0008544 9.32 KRT16 KRT17
3 keratinocyte differentiation GO:0030216 9.26 KRT10 KRT16
4 keratinization GO:0031424 9.26 KRT10 KRT16 KRT17 KRT7
5 cornification GO:0070268 8.92 KRT10 KRT16 KRT17 KRT7

Molecular functions related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.96 KRT16 KRT17
2 structural molecule activity GO:0005198 8.92 KRT10 KRT16 KRT17 KRT7

Sources for Bowen's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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