Aliases & Classifications for Bowen's Disease

MalaCards integrated aliases for Bowen's Disease:

Name: Bowen's Disease 53 73
Bowens Disease 55

Classifications:



External Ids:

UMLS 73 C0006079

Summaries for Bowen's Disease

MalaCards based summary : Bowen's Disease, also known as bowens disease, is related to actinic keratosis and oral leukoplakia. An important gene associated with Bowen's Disease is PCNA (Proliferating Cell Nuclear Antigen), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs Miconazole and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung.

Wikipedia : 76 Bowen\'s disease, also known as squamous cell carcinoma in situ is a neoplastic skin disease. It can be... more...

Related Diseases for Bowen's Disease

Diseases related to Bowen's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 actinic keratosis 30.2 KRT17 PCNA
2 oral leukoplakia 10.4 MKI67 PCNA
3 benign meningioma 10.3 MKI67 PCNA
4 leukoplakia 10.3 MKI67 PCNA
5 pachyonychia congenita 2 10.2 KRT16 KRT17
6 tinea corporis 10.2 KRT16 KRT17
7 median rhomboid glossitis 10.2 KRT16 KRT17
8 glossitis 10.2 KRT16 KRT17
9 palmoplantar keratoderma, epidermolytic 10.2 KRT16 KRT17
10 palmoplantar keratoderma, nonepidermolytic 10.2 KRT16 KRT17
11 cervical intraepithelial neoplasia 10.2 KRT17 MKI67
12 necrotizing sialometaplasia 10.1 KRT7 MKI67
13 mucinous cystadenocarcinoma 10.1 KRT7 PCNA
14 hidradenocarcinoma 10.1 KRT7 MKI67
15 clear cell basal cell carcinoma 10.1 KRT17 KRT7
16 malignant syringoma 10.1 KRT17 KRT7
17 keratosis 10.1
18 ampulla of vater neoplasm 10.0 KRT17 KRT7
19 ampulla of vater adenocarcinoma 10.0 KRT17 KRT7
20 infiltrative basal cell carcinoma 10.0 KRT17 KRT7
21 ovarian mucinous neoplasm 10.0 KRT17 KRT7
22 basaloid squamous cell carcinoma 10.0 KRT17 KRT7
23 endometrial adenocarcinoma 9.9 KRT7 MKI67
24 craniopharyngioma 9.9 KRT7 MKI67
25 basal cell carcinoma, infundibulocystic 9.8 KRT10 KRT17
26 monilethrix 9.8 KRT16 KRT17
27 squamous cell carcinoma 9.8
28 porokeratosis 9.8
29 polycystic liver disease 1 with or without kidney cysts 9.8 KRT17 KRT7
30 skin melanoma 9.8 MKI67 PCNA
31 discoid lupus erythematosus 9.8 KRT10 KRT16
32 nodular hidradenoma 9.7 KRT10 KRT7
33 inverted papilloma 9.7 KRT7 MKI67 PCNA
34 pinguecula 9.7 KRT10 KRT16
35 mucoepidermoid carcinoma 9.7 KRT7 MKI67 PCNA
36 adenoid cystic carcinoma 9.7 KRT7 MKI67 PCNA
37 malignant biphasic mesothelioma 9.7 KRT10 KRT7
38 porokeratosis 1, multiple types 9.7
39 epidermodysplasia verruciformis 9.7
40 paronychia 9.7
41 scrotum paget's disease 9.7
42 eccrine porocarcinoma 9.7
43 linear porokeratosis 9.7
44 keratosis, seborrheic 9.7 KRT10 KRT17
45 mucinous tubular and spindle renal cell carcinoma 9.7 KRT10 KRT7
46 ichthyosis bullosa of siemens 9.6 KRT10 KRT16
47 intraneural perineurioma 9.6 KRT10 KRT7
48 pericardial mesothelioma 9.6 KRT10 KRT7
49 cholesteatoma of middle ear 9.4 KRT10 KRT16
50 squamous cell carcinoma of the oral tongue 9.4 KRT10 KRT16 MKI67

Graphical network of the top 20 diseases related to Bowen's Disease:



Diseases related to Bowen's Disease

Symptoms & Phenotypes for Bowen's Disease

Drugs & Therapeutics for Bowen's Disease

Drugs for Bowen's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
2
Everolimus Approved Phase 4 159351-69-6 6442177
3
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
4
Mycophenolic acid Approved Phase 4 24280-93-1 446541
5
Azathioprine Approved Phase 4 446-86-6 2265
6
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
7
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
8 Anti-Infective Agents Phase 4,Phase 1
9 Cyclosporins Phase 4
10 Anti-Bacterial Agents Phase 4
11 Antibiotics, Antitubercular Phase 4
12 Immunosuppressive Agents Phase 4
13 Antifungal Agents Phase 4
14 Calcineurin Inhibitors Phase 4
15
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
16
Aminolevulinic acid Approved Phase 3,Phase 1,Phase 2,Not Applicable 106-60-5 137
17 interferons Phase 2, Phase 3
18 Adjuvants, Immunologic Phase 2, Phase 3
19 Interferon Inducers Phase 2, Phase 3
20 Methyl 5-aminolevulinate Phase 3,Phase 1,Not Applicable
21 Dermatologic Agents Phase 3,Phase 1,Phase 2,Not Applicable
22 Photosensitizing Agents Phase 3,Phase 1,Phase 2,Not Applicable
23 Pharmaceutical Solutions Phase 1, Phase 2
24
Lidocaine Approved, Vet_approved Phase 1,Not Applicable 137-58-6 3676
25
Silicon Approved, Investigational Phase 1 7440-21-3 4082203
26
Prilocaine Approved Phase 1 721-50-6 4906
27
Protoporphyrin IX Experimental Phase 1 553-12-8
28 EMLA Phase 1
29 Silicon phthalocyanine Phase 1
30 Central Nervous System Depressants Phase 1,Not Applicable
31 Micronutrients Phase 1
32 Sodium Channel Blockers Phase 1,Not Applicable
33 Anesthetics Phase 1,Not Applicable
34 Trace Elements Phase 1
35 Anesthetics, Local Phase 1,Not Applicable
36 Diuretics, Potassium Sparing Phase 1,Not Applicable
37 Anti-Arrhythmia Agents Phase 1,Not Applicable
38 Peripheral Nervous System Agents Phase 1,Not Applicable
39 Antiparasitic Agents Phase 1
40 Antiprotozoal Agents Phase 1
41 Antimalarials Phase 1
42 Antiviral Agents Phase 1
43
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
44
Racepinephrine Approved Not Applicable 329-65-7 838
45 Respiratory System Agents Not Applicable
46 Adrenergic Agents Not Applicable
47 Adrenergic Agonists Not Applicable
48 Adrenergic alpha-Agonists Not Applicable
49 Adrenergic beta-Agonists Not Applicable
50 Mydriatics Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Trial of Excision Versus Photodynamic Therapy in the Treatment of Bowen's Disease Terminated NCT00472706 Phase 4
2 Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol Terminated NCT01797315 Phase 4 Sirolimus
3 Topical Imiquimod for Bowen's Disease of the Head and Neck Unknown status NCT00384124 Phase 2, Phase 3 Imiquimod
4 PDT With Metvix® 160 mg/g Cream in Organ Transplant Recipients With Non-melanoma Skin Cancer Completed NCT00472459 Phase 3
5 Clinical Study Assessment of SR-T100 Topical Gel Against Actinic Keratosis Completed NCT02085395 Phase 2 SR-T100 ® Gel
6 Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Cutaneous Squamous Cell Carcinoma In Situ Completed NCT00329121 Phase 2 PEP005
7 DUSA: Cyclic PDT for the Prevention of AK & NMSC in Solid Organ Transplant Recipients Recruiting NCT03110159 Phase 1, Phase 2 Levulan® Kerastick®;BLU-U Blue Light Photodynamic Therapy
8 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Bowen's Disease Completed NCT01912976 Phase 1 Er:YAG AFL-PDT;MAL-PDT
9 Long-term Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy for Treatment of Lower Extremity Bowen's Disease Completed NCT03320447 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
10 Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II Mycosis Fungoides Completed NCT00103246 Phase 1 silicon phthalocyanine 4
11 Effects of Arsenic on Keratinocytes in a Skin Equivalent Model Unknown status NCT00166946 Not Applicable
12 Laser Assisted Drug Delivery in the Treatment of Superficial Non Melanoma Skin Cancer: a Randomized Controlled Trial Completed NCT03012009 Not Applicable MAL;lidocaine hydrochloride 2% with epinephrine
13 Reflectance Confocal Microscopy in Basal Cell Carcinoma Recruiting NCT02623101 Not Applicable
14 Photographing the Skin During Photodynamic Therapy Enrolling by invitation NCT03167762 Not Applicable
15 Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease No longer available NCT00535080 Metvix (methyl aminolevulinate)

Search NIH Clinical Center for Bowen's Disease

Genetic Tests for Bowen's Disease

Anatomical Context for Bowen's Disease

MalaCards organs/tissues related to Bowen's Disease:

41
Skin, Testes, Lung, Bone

Publications for Bowen's Disease

Articles related to Bowen's Disease:

(show top 50) (show all 150)
# Title Authors Year
1
Cryosurgery + 5% 5-Fluorouracil for Treatment of Superficial Basal Cell Carcinoma and Bowen's Disease [Formula: see text]. ( 29457484 )
2018
2
Clinical experience of ingenol mebutate gel for the treatment of Bowen's disease. ( 29383745 )
2018
3
Bowen's Disease: Long-term Results of Treatment with 5-Fluorouracil Cream, Photodynamic Therapy or Surgical Excision. ( 29135015 )
2018
4
Accuracy of dermoscopic criteria for the differentiation between superficial basal cell carcinoma and Bowen's disease. ( 29633377 )
2018
5
Ablative fractional laser-assisted photodynamic therapy provides superior long-term efficacy compared to standard methyl aminolevulinate photodynamic therapy for lower extremity Bowen's disease. ( 29857012 )
2018
6
Characterization of centriole duplication in human epidermis, Bowen's disease, and squamous cell carcinoma. ( 29615326 )
2018
7
Differential proteomic analysis of actinic keratosis, Bowen's disease and cutaneous squamous cell carcinoma by label-free LC-MS/MS. ( 29665991 )
2018
8
Epithelial-mesenchymal transition in Bowen's disease when arising de novo and acquiring invasive capacity. ( 29864224 )
2018
9
The role of reflectance confocal microscopy in a case of Bowen's disease difficult to diagnose. ( 29445580 )
2018
10
Laser-assisted photodynamic therapy for superficial basal cell carcinoma and Bowen's Disease: a randomised intra-patient comparison between a continuous and a fractional ablative CO<sub>2</sub> laser mode. ( 29633367 )
2018
11
High-risk human papillomavirus in a child with digital pigmented Bowen's disease: Case report and dermoscopic findings. ( 29931706 )
2018
12
Image Gallery: Bowen's disease of a nail unit presenting with 'woodgrain appearance' - a new dermoscopic finding. ( 29357581 )
2018
13
Cyclin D1 promoter -56 and -54bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen's disease. ( 29103775 )
2018
14
Effectiveness of photodynamic therapy in refractory plaque-stage mycosis fungoides associated with Bowen's disease. ( 28198112 )
2017
15
A case of pigmented Bowen's disease. ( 28225972 )
2017
16
Lobulated Bowen's Disease with a Clear Cell Change. ( 28761300 )
2017
17
Pigmented Bowen's disease associated with high-risk HPV simulating melanoma of the hand. ( 29166507 )
2017
18
Trial of hyperthermic treatment for Bowen's disease with disposable chemical pocket warmers: A report of two cases. ( 29239019 )
2017
19
A Case of Pagetoid Bowen's Disease. ( 29237947 )
2017
20
A Case of Bowen's Disease Successfully Treated with Ingenol Mebutate Gel. ( 28761314 )
2017
21
Phasor-FLIM as a Screening Tool for the Differential Diagnosis of Actinic Keratosis, Bowen's Disease, and Basal Cell Carcinoma. ( 28661125 )
2017
22
What's new in dermoscopy of Bowen's disease: two new dermoscopic signs and its differential diagnosis. ( 28832993 )
2017
23
Giant neglected Bowen's disease lesion treated successfully with topical 5-fluorouracil. ( 28752147 )
2017
24
p16 immunostaining in keratinocytic neoplasia in organ transplant recipients: Bowen's disease shows a characteristic pattern. ( 27717097 )
2017
25
Bowen's disease: Two case reports of a giant and dwarf lesions. ( 28643763 )
2017
26
Clinical, histological and therapeutic features of Bowen's disease. ( 28523295 )
2017
27
Reflectance confocal microscopy of Pigmented Bowen's disease: misleading dendritic cells. ( 27430726 )
2017
28
Polydactylous Bowen's Disease in an Immunocompromised Patient: Resolution of All Lesions After Mohs Surgery on a Single Lesion. ( 28930791 )
2017
29
Bowen's Disease Associated With Two Human Papilloma Virus Types. ( 29202554 )
2017
30
Extragenital Human Papillomavirus 16-associated Bowen's Disease. ( 28216736 )
2017
31
In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using dynamic optical coherence tomography. ( 28502083 )
2017
32
Human herpesvirus-8 and human cytomegalovirus infections in Bowen's disease: Is there any association? ( 28366922 )
2017
33
Effectiveness of photodynamic therapy in Bowen's disease: a retrospective observational study in 423 lesions. ( 28190258 )
2017
34
Detection of human papillomavirus type 35 in recurrent Bowen's disease lesions of the fingers. ( 28120774 )
2017
35
Clinical, histological, and immunohistochemical markers of resistance to Methyl-aminolevulinate Photodynamic therapy in Bowen's disease. ( 28886215 )
2017
36
Photodynamic therapy with epidermal ablation using fractional carbon-dioxide laser in the treatment of Bowen's disease: A case series. ( 28457851 )
2017
37
Spindle cell squamous cell carcinoma arising in Bowen's disease: Case report and review of the published work. ( 28370387 )
2017
38
Genital Bowen's Disease in a Bulgarian Patient: Complete Remission after Surgical Approach. ( 28785358 )
2017
39
Topical Photodynamic Therapy for Primary Bowen's Disease and Basal Cell Carcinoma - Optimising Patient Selection. ( 28028807 )
2016
40
Giant Bowen's disease histologically showing Borst-Jadassohn phenomenon and complicated with squamous cell carcinoma development. ( 26373350 )
2016
41
Ingenol Mebutate 150 mg as Physician-Directed Treatment of Bowen's Disease Under Occlusion. ( 27512986 )
2016
42
Successful Treatment of Relapsing Bowen's Disease with Ingenol Mebutate: The Use of Dermoscopy to Monitor the Therapeutic Response. ( 27513936 )
2016
43
Porokeratosis simulating Bowen's disease on dermoscopy. ( 28300916 )
2016
44
Case of pigmented Bowen's disease on the volar aspect of the finger dermoscopically mimicking melanoma in situ. ( 27790749 )
2016
45
Pigmented Bowen's disease presenting with a &amp;quot;starburst&amp;quot; pattern. ( 27867748 )
2016
46
Human papillomavirus infection and p16 expression in the immunocompetent patients with extragenital/extraungual Bowen's disease. ( 27342647 )
2016
47
Verrucous Bowen's disease. ( 27595211 )
2016
48
Anti-retroviral therapy's miracle in the treatment of Bowen's disease in a human immunodeficiency virus-positive patient: A rare case report. ( 27890959 )
2016
49
Onychocytic matricoma as an underrecognized benign mimicker of subungual malignant melanoma and Bowen's disease. ( 27650048 )
2016
50
Pagetoid Bowen's disease of vulva: Excellent response to imiquimod. ( 27506507 )
2016

Variations for Bowen's Disease

Expression for Bowen's Disease

Search GEO for disease gene expression data for Bowen's Disease.

Pathways for Bowen's Disease

Pathways related to Bowen's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 KRT10 KRT16 KRT17 KRT7
2 11.82 KRT10 KRT17 KRT7
3
Show member pathways
11.38 KRT10 KRT16 KRT17 KRT7
4
Show member pathways
11.17 KRT16 KRT17 KRT7
5 11.13 MKI67 PCNA

GO Terms for Bowen's Disease

Cellular components related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 KRT10 KRT16 KRT17 KRT7 PCNA
2 intermediate filament GO:0005882 8.92 KRT10 KRT16 KRT17 KRT7

Biological processes related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.33 KRT16 MKI67 PCNA
2 epidermis development GO:0008544 9.32 KRT16 KRT17
3 keratinocyte differentiation GO:0030216 9.26 KRT10 KRT16
4 keratinization GO:0031424 9.26 KRT10 KRT16 KRT17 KRT7
5 cornification GO:0070268 8.92 KRT10 KRT16 KRT17 KRT7

Molecular functions related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.96 KRT16 KRT17
2 structural molecule activity GO:0005198 8.92 KRT10 KRT16 KRT17 KRT7

Sources for Bowen's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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