MCID: BWN006
MIFTS: 38

Bowen's Disease

Categories: Rare diseases

Aliases & Classifications for Bowen's Disease

MalaCards integrated aliases for Bowen's Disease:

Name: Bowen's Disease 53 73
Bowens Disease 55

Classifications:



External Ids:

UMLS 73 C0006079

Summaries for Bowen's Disease

MalaCards based summary : Bowen's Disease, also known as bowens disease, is related to actinic keratosis and keratosis, seborrheic. An important gene associated with Bowen's Disease is PCNA (Proliferating Cell Nuclear Antigen), and among its related pathways/superpathways are Developmental Biology and Cytoskeletal Signaling. The drugs Mycophenolic acid and Azathioprine have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and lung.

Wikipedia : 76 Bowen''s disease, also known as squamous cell carcinoma in situ is a neoplastic skin disease. It can be... more...

Related Diseases for Bowen's Disease

Diseases related to Bowen's Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 72)
# Related Disease Score Top Affiliating Genes
1 actinic keratosis 30.3 KRT17 PCNA
2 keratosis, seborrheic 29.5 KRT10 KRT17
3 basal cell carcinoma 29.0 KRT10 KRT16 KRT17 KRT7 MKI67
4 keratosis 10.2
5 oral leukoplakia 10.1 MKI67 PCNA
6 leukoplakia 10.1 MKI67 PCNA
7 benign meningioma 10.1 MKI67 PCNA
8 squamous cell carcinoma 10.1
9 meningioma, radiation-induced 10.1 MKI67 PCNA
10 palmoplantar keratoderma, bothnian type 10.1 KRT16 KRT17
11 tinea corporis 10.1 KRT16 KRT17
12 median rhomboid glossitis 10.1 KRT16 KRT17
13 cervical intraepithelial neoplasia 10.0 KRT17 MKI67
14 necrotizing sialometaplasia 10.0 KRT7 MKI67
15 hidradenocarcinoma 10.0 KRT7 MKI67
16 mucinous cystadenocarcinoma 10.0 KRT7 PCNA
17 clear cell basal cell carcinoma 10.0 KRT17 KRT7
18 ampulla of vater adenocarcinoma 10.0 KRT17 KRT7
19 infiltrative basal cell carcinoma 10.0 KRT17 KRT7
20 ovarian mucinous neoplasm 10.0 KRT17 KRT7
21 pregnancy adenoma 10.0 KRT17 KRT7
22 basaloid squamous cell carcinoma 10.0 KRT17 KRT7
23 cavernous hemangioma 10.0 KRT7 MKI67
24 ampulla of vater cancer 10.0 KRT17 KRT7
25 craniopharyngioma 10.0 KRT7 MKI67
26 acanthoma 10.0 KRT10 KRT17
27 monilethrix 10.0 KRT16 KRT17
28 basal cell carcinoma, infundibulocystic 10.0 KRT10 KRT17
29 eccrine acrospiroma 9.9 KRT10 KRT17
30 polycystic liver disease 1 with or without kidney cysts 9.9 KRT17 KRT7
31 basal cell carcinoma 1 9.9
32 porokeratosis 9.9
33 in situ carcinoma 9.9
34 discoid lupus erythematosus 9.9 KRT10 KRT16
35 meningioma, familial 9.9 MKI67 PCNA
36 pinguecula 9.9 KRT10 KRT16
37 nodular hidradenoma 9.9 KRT10 KRT7
38 malignant biphasic mesothelioma 9.9 KRT10 KRT7
39 endometrial adenocarcinoma 9.9 KRT7 MKI67
40 inverted papilloma 9.9 KRT7 MKI67 PCNA
41 gastric squamous cell carcinoma 9.9 KRT10 KRT7
42 palmoplantar keratoderma, epidermolytic 9.9 KRT10 KRT16
43 mucinous tubular and spindle renal cell carcinoma 9.9 KRT10 KRT7
44 mucoepidermoid carcinoma 9.9 KRT7 MKI67 PCNA
45 nevus, epidermal 9.9 KRT10 KRT16
46 intraneural perineurioma 9.9 KRT10 KRT7
47 ileum cancer 9.9 KRT10 KRT7
48 pericardial mesothelioma 9.9 KRT10 KRT7
49 cholesteatoma of middle ear 9.8 KRT10 KRT16
50 lichen planus 9.8 KRT10 KRT16

Graphical network of the top 20 diseases related to Bowen's Disease:



Diseases related to Bowen's Disease

Symptoms & Phenotypes for Bowen's Disease

Drugs & Therapeutics for Bowen's Disease

Drugs for Bowen's Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved Phase 4 24280-93-1 446541
2
Azathioprine Approved Phase 4 446-86-6 2265
3
Tacrolimus Approved, Investigational Phase 4 104987-11-3 445643 439492
4
Everolimus Approved Phase 4 159351-69-6 6442177
5
Sirolimus Approved, Investigational Phase 4 53123-88-9 46835353 6436030 5284616
6
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
7 Immunologic Factors Phase 4,Phase 2,Phase 3
8 Anti-Infective Agents Phase 4,Phase 1
9 Antibiotics, Antitubercular Phase 4
10 Cyclosporins Phase 4
11 Antifungal Agents Phase 4
12 Calcineurin Inhibitors Phase 4
13 Immunosuppressive Agents Phase 4
14 Anti-Bacterial Agents Phase 4
15
Imiquimod Approved, Investigational Phase 2, Phase 3 99011-02-6 57469
16
Aminolevulinic acid Approved Phase 3,Phase 1,Phase 2,Not Applicable 106-60-5 137
17 interferons Phase 2, Phase 3
18 Adjuvants, Immunologic Phase 2, Phase 3
19 Interferon Inducers Phase 2, Phase 3
20 Photosensitizing Agents Phase 3,Phase 1,Phase 2,Not Applicable
21 Methyl 5-aminolevulinate Phase 3,Phase 1,Not Applicable
22 Dermatologic Agents Phase 3,Phase 1,Phase 2,Not Applicable
23
Ethanol Approved Phase 2 64-17-5 702
24
Petrolatum Approved, Investigational Phase 2 8009-03-8
25 Pharmaceutical Solutions Phase 1, Phase 2
26
Prilocaine Approved Phase 1 721-50-6 4906
27
Lidocaine Approved, Vet_approved Phase 1,Not Applicable 137-58-6 3676
28
Silicon Approved, Investigational Phase 1 7440-21-3 4082203
29
Protoporphyrin IX Experimental Phase 1 553-12-8
30 Anesthetics, Local Phase 1,Not Applicable
31 Peripheral Nervous System Agents Phase 1,Not Applicable
32 Central Nervous System Depressants Phase 1,Not Applicable
33 Anesthetics Phase 1,Not Applicable
34 Diuretics, Potassium Sparing Phase 1,Not Applicable
35 EMLA Phase 1
36 Sodium Channel Blockers Phase 1,Not Applicable
37 Anti-Arrhythmia Agents Phase 1,Not Applicable
38 Micronutrients Phase 1
39 Antiviral Agents Phase 1
40 Silicon phthalocyanine Phase 1
41 Antiprotozoal Agents Phase 1
42 Trace Elements Phase 1
43 Antiparasitic Agents Phase 1
44 Antimalarials Phase 1
45
Epinephrine Approved, Vet_approved Not Applicable 51-43-4 5816
46
Racepinephrine Approved Not Applicable 329-65-7 838
47 Bronchodilator Agents Not Applicable
48 Mydriatics Not Applicable
49 Adrenergic beta-Agonists Not Applicable
50 Anti-Asthmatic Agents Not Applicable

Interventional clinical trials:

(show all 16)
# Name Status NCT ID Phase Drugs
1 Trial of Excision Versus Photodynamic Therapy in the Treatment of Bowen's Disease Terminated NCT00472706 Phase 4
2 Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol Terminated NCT01797315 Phase 4 Sirolimus
3 Topical Imiquimod for Bowen's Disease of the Head and Neck Unknown status NCT00384124 Phase 2, Phase 3 Imiquimod
4 PDT With Metvix® 160 mg/g Cream in Organ Transplant Recipients With Non-melanoma Skin Cancer Completed NCT00472459 Phase 3
5 Clinical Study Assessment of SR-T100 Topical Gel Against Actinic Keratosis Completed NCT02085395 Phase 2 SR-T100 ® Gel
6 Study to Determine the Safety of Two Applications of PEP005 Topical Gel to Cutaneous Squamous Cell Carcinoma In Situ Completed NCT00329121 Phase 2 PEP005
7 Identification of Compound From Brinjal Peel Extract in the Treatment of Palmar Arsenical Keratosis and Bowen's Disease Recruiting NCT03641079 Phase 2 Brinjal peel extract containing cream
8 DUSA: Cyclic PDT for the Prevention of AK & NMSC in Solid Organ Transplant Recipients Recruiting NCT03110159 Phase 1, Phase 2 Levulan® Kerastick®;BLU-U Blue Light Photodynamic Therapy
9 Study of Methyl Aminolaevulinate Photodynamic Therapy With and Without Er:YAG Laser in Bowen's Disease Completed NCT01912976 Phase 1 Er:YAG AFL-PDT;MAL-PDT
10 Long-term Efficacy of Ablative Fractional Laser-assisted Photodynamic Therapy for Treatment of Lower Extremity Bowen's Disease Completed NCT03320447 Phase 1 lidocaine-prilocaine 5% cream application;methyl-aminolevulinate application
11 Photodynamic Therapy Using Silicon Phthalocyanine 4 in Treating Patients With Actinic Keratosis, Bowen's Disease, Skin Cancer, or Stage I or Stage II Mycosis Fungoides Completed NCT00103246 Phase 1 silicon phthalocyanine 4
12 Effects of Arsenic on Keratinocytes in a Skin Equivalent Model Unknown status NCT00166946 Not Applicable
13 Laser Assisted Drug Delivery in the Treatment of Superficial Non Melanoma Skin Cancer: a Randomized Controlled Trial Completed NCT03012009 Not Applicable MAL;lidocaine hydrochloride 2% with epinephrine
14 Reflectance Confocal Microscopy in Basal Cell Carcinoma Recruiting NCT02623101 Not Applicable
15 Photographing the Skin During Photodynamic Therapy Enrolling by invitation NCT03167762 Not Applicable
16 Compassionate Use of Metvix® (Methyl Aminolevulinate) Photodynamic Therapy (PDT) in Subjects With Field Actinic Keratoses, Large/Multiple Superficial Basal Cell Carcinomas (BCCs), or Bowen's Disease No longer available NCT00535080 Metvix (methyl aminolevulinate)

Search NIH Clinical Center for Bowen's Disease

Genetic Tests for Bowen's Disease

Anatomical Context for Bowen's Disease

MalaCards organs/tissues related to Bowen's Disease:

41
Skin, Lymph Node, Lung, Prostate, Kidney, Liver, Tongue

Publications for Bowen's Disease

Articles related to Bowen's Disease:

(show top 50) (show all 730)
# Title Authors Year
1
Cryosurgery + 5% 5-Fluorouracil for Treatment of Superficial Basal Cell Carcinoma and Bowen's Disease [Formula: see text]. ( 29457484 )
2018
2
Clinical experience of ingenol mebutate gel for the treatment of Bowen's disease. ( 29383745 )
2018
3
Bowen's Disease: Long-term Results of Treatment with 5-Fluorouracil Cream, Photodynamic Therapy or Surgical Excision. ( 29135015 )
2018
4
Accuracy of dermoscopic criteria for the differentiation between superficial basal cell carcinoma and Bowen's disease. ( 29633377 )
2018
5
Ablative fractional laser-assisted photodynamic therapy provides superior long-term efficacy compared to standard methyl aminolevulinate photodynamic therapy for lower extremity Bowen's disease. ( 29857012 )
2018
6
Characterization of centriole duplication in human epidermis, Bowen's disease, and squamous cell carcinoma. ( 29615326 )
2018
7
Differential proteomic analysis of actinic keratosis, Bowen's disease and cutaneous squamous cell carcinoma by label-free LC-MS/MS. ( 29665991 )
2018
8
Epithelial-mesenchymal transition in Bowen's disease when arising de novo and acquiring invasive capacity. ( 29864224 )
2018
9
The role of reflectance confocal microscopy in a case of Bowen's disease difficult to diagnose. ( 29445580 )
2018
10
Laser-assisted photodynamic therapy for superficial basal cell carcinoma and Bowen's Disease: a randomised intra-patient comparison between a continuous and a fractional ablative CO<sub>2</sub> laser mode. ( 29633367 )
2018
11
High-risk human papillomavirus in a child with digital pigmented Bowen's disease: Case report and dermoscopic findings. ( 29931706 )
2018
12
Image Gallery: Bowen's disease of a nail unit presenting with 'woodgrain appearance' - a new dermoscopic finding. ( 29357581 )
2018
13
Cyclin D1 promoter -56 and -54bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen's disease. ( 29103775 )
2018
14
Comparison of oxidative stress on DNA, protein and lipids in patients with actinic keratosis, Bowen's disease and squamous cell carcinoma. ( 30222205 )
2018
15
Merkel cell carcinoma arising on a pre-existing Bowen's disease: is it just by chance? ( 26222729 )
2018
16
Bowen's Disease in Dermoscopy. ( 29989873 )
2018
17
Enhancement of Photodynamic Therapy for Bowen's Disease Using Plum-Blossom Needling to Augment Drug Delivery. ( 29994952 )
2018
18
Identification of a human papillomavirus type 58 lineage in multiple Bowen's disease on the fingers: Case report and published work review. ( 30035309 )
2018
19
Collision tumor: pigmented Bowen's disease and seborrheic keratosis. ( 30156629 )
2018
20
Photodynamic therapy for Bowen's Disease (squamous cell carcinoma in situ) current review and update. ( 30240928 )
2018
21
Bowen's Disease of the Nipple. ( 30323750 )
2018
22
Hypomelanotic melanoma simulating pigmented Bowen's disease and its challenging dermoscopic features. ( 30353916 )
2018
23
On "Multicentric Anogenital Bowen's Disease Treated with Imiquimod and CO2 Laser". ( 30413221 )
2018
24
Multicentric Anogenital Bowen's Disease Treated with Imiquimod and CO2 Laser. ( 30413229 )
2018
25
Acral and Multicentric Pigmented Bowen's Disease in HIV-Positive Patients: Report on Two Unusual Cases. ( 30504981 )
2018
26
Effectiveness of photodynamic therapy in refractory plaque-stage mycosis fungoides associated with Bowen's disease. ( 28198112 )
2017
27
A case of pigmented Bowen's disease. ( 28225972 )
2017
28
Lobulated Bowen's Disease with a Clear Cell Change. ( 28761300 )
2017
29
Pigmented Bowen's disease associated with high-risk HPV simulating melanoma of the hand. ( 29166507 )
2017
30
Trial of hyperthermic treatment for Bowen's disease with disposable chemical pocket warmers: A report of two cases. ( 29239019 )
2017
31
A Case of Pagetoid Bowen's Disease. ( 29237947 )
2017
32
A Case of Bowen's Disease Successfully Treated with Ingenol Mebutate Gel. ( 28761314 )
2017
33
Phasor-FLIM as a Screening Tool for the Differential Diagnosis of Actinic Keratosis, Bowen's Disease, and Basal Cell Carcinoma. ( 28661125 )
2017
34
What's new in dermoscopy of Bowen's disease: two new dermoscopic signs and its differential diagnosis. ( 28832993 )
2017
35
Giant neglected Bowen's disease lesion treated successfully with topical 5-fluorouracil. ( 28752147 )
2017
36
p16 immunostaining in keratinocytic neoplasia in organ transplant recipients: Bowen's disease shows a characteristic pattern. ( 27717097 )
2017
37
Bowen's disease: Two case reports of a giant and dwarf lesions. ( 28643763 )
2017
38
Clinical, histological and therapeutic features of Bowen's disease. ( 28523295 )
2017
39
Reflectance confocal microscopy of Pigmented Bowen's disease: misleading dendritic cells. ( 27430726 )
2017
40
Polydactylous Bowen's Disease in an Immunocompromised Patient: Resolution of All Lesions After Mohs Surgery on a Single Lesion. ( 28930791 )
2017
41
Bowen's Disease Associated With Two Human Papilloma Virus Types. ( 29202554 )
2017
42
Extragenital Human Papillomavirus 16-associated Bowen's Disease. ( 28216736 )
2017
43
In vivo microvascular imaging of cutaneous actinic keratosis, Bowen's disease and squamous cell carcinoma using dynamic optical coherence tomography. ( 28502083 )
2017
44
Human herpesvirus-8 and human cytomegalovirus infections in Bowen's disease: Is there any association? ( 28366922 )
2017
45
Effectiveness of photodynamic therapy in Bowen's disease: a retrospective observational study in 423 lesions. ( 28190258 )
2017
46
Detection of human papillomavirus type 35 in recurrent Bowen's disease lesions of the fingers. ( 28120774 )
2017
47
Clinical, histological, and immunohistochemical markers of resistance to Methyl-aminolevulinate Photodynamic therapy in Bowen's disease. ( 28886215 )
2017
48
Photodynamic therapy with epidermal ablation using fractional carbon-dioxide laser in the treatment of Bowen's disease: A case series. ( 28457851 )
2017
49
Spindle cell squamous cell carcinoma arising in Bowen's disease: Case report and review of the published work. ( 28370387 )
2017
50
Aminoleveulinate photodynamic therapy (ALA-PDT) for Bowen's disease in a SLE patient: Case report and literature review. ( 28108283 )
2017

Variations for Bowen's Disease

Expression for Bowen's Disease

Search GEO for disease gene expression data for Bowen's Disease.

Pathways for Bowen's Disease

Pathways related to Bowen's Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.83 KRT10 KRT16 KRT17 KRT7
2 11.82 KRT10 KRT17 KRT7
3
Show member pathways
11.38 KRT10 KRT16 KRT17 KRT7
4
Show member pathways
11.17 KRT16 KRT17 KRT7
5 11.13 MKI67 PCNA

GO Terms for Bowen's Disease

Cellular components related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.35 KRT10 KRT16 KRT17 KRT7 PCNA
2 intermediate filament GO:0005882 8.92 KRT10 KRT16 KRT17 KRT7

Biological processes related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.33 KRT16 MKI67 PCNA
2 epidermis development GO:0008544 9.32 KRT16 KRT17
3 keratinocyte differentiation GO:0030216 9.26 KRT10 KRT16
4 keratinization GO:0031424 9.26 KRT10 KRT16 KRT17 KRT7
5 cornification GO:0070268 8.92 KRT10 KRT16 KRT17 KRT7

Molecular functions related to Bowen's Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.96 KRT16 KRT17
2 structural molecule activity GO:0005198 8.92 KRT10 KRT16 KRT17 KRT7

Sources for Bowen's Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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