MCID: BRC010
MIFTS: 31

Brachial Plexus Lesion

Categories: Neuronal diseases

Aliases & Classifications for Brachial Plexus Lesion

MalaCards integrated aliases for Brachial Plexus Lesion:

Name: Brachial Plexus Lesion 12 15 71
Brachial Plexus Injuries 53 42
Brachial Plexus Lesions 12

Classifications:



External Ids:

Disease Ontology 12 DOID:8443
ICD9CM 34 353.0
ICD10 32 S14.3
UMLS 71 C0006091

Summaries for Brachial Plexus Lesion

NINDS : 53 The brachial plexus is a network of nerves that conducts signals from the spine to the shoulder, arm, and hand. Brachial plexus injuries are caused by damage to those nerves. Symptoms may include a limp or paralyzed arm; lack of muscle control in the arm, hand, or wrist; and a lack of feeling or sensation in the arm or hand.  Brachial plexus injuries can occur as a result of shoulder trauma, tumors, or inflammation.  There is a rare syndrome called Parsonage-Turner Syndrome, or brachial plexitis, which causes inflammation of the brachial plexus without any obvious shoulder injury.  This syndrome can begin with severe shoulder or arm pain followed by weakness and numbness. In infants, brachial plexus injuries may happen during birth if the baby’s shoulder is stretched during passage in the birth canal.    The severity of a brachial plexus injury is determined by the type of damage done to the nerves.  The most severe type,avulsion, is caused when the nerve root is severed or cut from the spinal cord.  There is also an incomplete form of avulsion in which part of the nerve is damaged and which leaves some opportunity for the nerve to slowly recover function.  Neuropraxia, or stretch injury, is the mildest type of injury.  Neuropraxia damages the protective covering of the nerve, which causes problems with nerve signal conduction, but does not always damage the nerve underneath.

MalaCards based summary : Brachial Plexus Lesion, also known as brachial plexus injuries, is related to non-recovering obstetric brachial plexus lesion and klumpke paralysis. An important gene associated with Brachial Plexus Lesion is RHBDD3 (Rhomboid Domain Containing 3). The drugs Anesthetics and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and brain.

Disease Ontology : 12 A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus.

MedlinePlus : 42 The brachial plexus is a network of nerves that sends signals from the spine to the shoulder, arm, and hand. Damage to the brachial plexus can cause symptoms such as A limp or paralyzed arm Lack of muscle control in the arm, hand, or wrist Lack of feeling or sensation in the arm or hand Brachial plexus injuries can happen because of shoulder trauma, tumors, or inflammation. Sometimes they happen during childbirth when a baby's shoulders become stuck during delivery and the nerves stretch or tear. Some brachial plexus injuries may heal without treatment. Many children who are injured during birth improve or recover by 3 to 4 months of age. Treatment includes physical therapy and, in some cases, surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 74 A brachial plexus injury (BPI), also known as brachial plexus lesion, is an injury to the brachial... more...

Related Diseases for Brachial Plexus Lesion

Diseases related to Brachial Plexus Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 123)
# Related Disease Score Top Affiliating Genes
1 non-recovering obstetric brachial plexus lesion 12.6
2 klumpke paralysis 11.9
3 erb-duchenne and dejerine-klumpke palsies 11.9
4 peripheral nervous system disease 11.8
5 chronic pain 10.4
6 head injury 10.4
7 paresthesia 10.4
8 spinal cord injury 10.4
9 meningocele 10.3
10 gestational diabetes 10.3
11 neuropathy 10.3
12 plexopathy 10.3
13 fetal macrosomia 10.2
14 autonomic dysfunction 10.2
15 neuroma 10.2
16 scoliosis 10.2
17 mononeuropathy 10.2
18 quadriplegia 10.2
19 substance abuse 10.2
20 complex regional pain syndrome 10.2
21 spastic paraparesis 10.2
22 horner's syndrome 10.2
23 thoracic outlet syndrome 10.2
24 hand skill, relative 10.1
25 ocular motor apraxia 10.1
26 siderosis 10.1
27 hemiplegia 10.1
28 polyneuropathy 10.1
29 pneumothorax 10.1
30 neuritis 10.1
31 motor neuron disease 10.1
32 radiculopathy 10.1
33 demyelinating polyneuropathy 10.1
34 parsonage turner syndrome 10.1
35 superficial siderosis 10.1
36 muscular atrophy 10.1
37 neurofibroma 10.1
38 hereditary neuropathies 10.1
39 spondyloarthropathy 1 9.9
40 breast cancer 9.9
41 coarctation of aorta 9.9
42 seizures, benign familial neonatal, 1 9.9
43 fibrosis of extraocular muscles, congenital, 1 9.9
44 marfan syndrome 9.9
45 amyotrophy, hereditary neuralgic 9.9
46 pectus excavatum 9.9
47 scheuermann disease 9.9
48 sprengel deformity 9.9
49 tetralogy of fallot 9.9
50 uterine anomalies 9.9

Graphical network of the top 20 diseases related to Brachial Plexus Lesion:



Diseases related to Brachial Plexus Lesion

Symptoms & Phenotypes for Brachial Plexus Lesion

Drugs & Therapeutics for Brachial Plexus Lesion

Drugs for Brachial Plexus Lesion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anesthetics Phase 1, Phase 2
2 Respiratory System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Autologous Bone Marrow Transplantation for Muscle Improvement in Traumatic Brachial Plexus Injuries Unknown status NCT00755586 Phase 1, Phase 2
2 The Optimal Surgical Strategy for the Treatment of Total Brachial Plexus Avulsion Injury Patients Completed NCT03162393
3 SURGICAL REPERCUSSIONS IN RESPIRATORY SYSTEM, TRUNK BIOMECHANICAL, FUNCTIONAL CAPACITY AND QUALITY OF LIFE IN PATIENTS WITH POST-TRAUMATIC BRACHIAL PLEXUS INJURIES: A PROSPECTIVE COHORT STUDY Completed NCT03377712
4 Is Mental Motor Imagery Training Using "GHOST", a Novel BCI-VR Feedback System (Brain Computer Interface and Virtual Reality) Efficient and Safe for Pain Relief in Phantom Limb Pain After Upper Limb Amputation or Brachial Plexus Lesion Recruiting NCT03889353
5 Novel MRI for Diagnosing Traumatic Brachial Plexus Injuries Recruiting NCT04058821
6 Combined Nerve and Tendon Transfer for the Restoration of Hand Function in Individuals With Tetraplegia Not yet recruiting NCT04276181
7 Does Early Supination and External Rotation Repositioning in Children With Birth Related Brachial Plexus Injury Have Benefit? A Randomized Controlled Trial of the Sup-ER Protocol. Terminated NCT01933438
8 Sup-ER Splinting: Does Early Passive Positioning in Supination and External Rotation in Children With Birth Related Brachial Plexus Injury Have Benefit? Withdrawn NCT01663428
9 Home Program Education for Patients With Low Back Pain: Does it Matter? A Prospective Study Withdrawn NCT02427438

Search NIH Clinical Center for Brachial Plexus Lesion

Genetic Tests for Brachial Plexus Lesion

Anatomical Context for Brachial Plexus Lesion

MalaCards organs/tissues related to Brachial Plexus Lesion:

40
Spinal Cord, Skin, Brain, Bone, Bone Marrow, Cortex, Liver

Publications for Brachial Plexus Lesion

Articles related to Brachial Plexus Lesion:

(show top 50) (show all 1068)
# Title Authors PMID Year
1
MRI for Detecting Root Avulsions in Traumatic Adult Brachial Plexus Injuries: A Systematic Review and Meta-Analysis of Diagnostic Accuracy. 42 61
31429680 2019
2
Indirect Cost of Traumatic Brachial Plexus Injuries in the United States. 42 61
31436660 2019
3
An assessment of fatigability following nerve transfer to reinnervate elbow flexor muscles. 42
31256676 2019
4
Role of Early Referral and Surgical Intervention in Brachial Plexus Birth Palsy: Awareness Among Obstetricians and Pediatricians in a Teaching Hospital. 61
31652077 2020
5
Reliability of Various Predictors for Preoperative Diagnosis of Infraclavicular Brachial Plexus Lesions with Shoulder and/or Elbow Paresis. 61
32207120 2020
6
Great Occipital Nerve as Donor Nerve for Neurotization With Suprascapular Nerve in Total Braqchial Plexus Injuries: Nerve Transfer Technique. 61
31764485 2020
7
Comparison Between Supraclavicular Versus Video-Assisted Intrathoracic Phrenic Nerve Section for Transfer in Patients With Traumatic Brachial Plexus Injuries: Case Series. 61
32497215 2020
8
Recovery of shoulder abduction in traumatic brachial plexus palsy: a systematic review and meta-analysis of nerve transfer versus nerve graft. 61
30997618 2020
9
Differences in strength fatigue when using different donors in traumatic brachial plexus injuries. 61
32556814 2020
10
Intercostal to musculocutaneous nerve transfer in patients with complete traumatic brachial plexus injuries: case series. 61
32506331 2020
11
Comparison of autograft versus allograft in the surgical repair of pediatric obstetrical brachial plexus injuries. 61
32534482 2020
12
Feasibility of the Oberlin Procedure in Late Presentation Cases of C5-C6 and C5-C7 Brachial Plexus Injuries in Adults. 61
32486925 2020
13
Elbow flexion strength and contractile activity after partial ulnar nerve or intercostal nerve transfers for brachial plexus injuries. 61
32380918 2020
14
Surgical treatment of birth-related brachial plexus injuries: a historical review. 61
32468240 2020
15
The Effect of Distal Transfer of the Spinal Accessory Nerve to the Suprascapular Nerve on the Shoulder Reanimation in Spontaneously Partially Recovered Obstetric Brachial Plexus Lesion. 61
32472795 2020
16
Perineural invasion in intramedullary spinal cord metastasis. 61
32003581 2020
17
Assessment of Motor Repertoire in 3- to 5-Month-Old Infants With Obstetric Brachial Plexus Lesion. 61
32218073 2020
18
Commentary on "Assessment of Motor Repertoire in 3- to 5-Month-Old Infants With Obstetric Brachial Plexus Lesion". 61
32218074 2020
19
Brachial plexus injury after shoulder dislocation: a literature review. 61
29961154 2020
20
Contralateral C7 transfers: An innovative approach to improving peripheral neuropathic pain after traumatic brachial plexus injury with C5 rupture and avulsion of C6, C7, C8 and T1. A case series study. 61
32035358 2020
21
Epidemiology, etiology, and types of severe adult brachial plexus injuries requiring surgical repair: systematic review and meta-analysis. 61
30014280 2020
22
Surgical reconstructions for adult brachial plexus injuries. Part I: Treatments for combined C5 and C6 injuries, with or without C7 injuries. 61
32156416 2020
23
Predictors of functional outcome after peripheral nerve injury and compression. 61
32334939 2020
24
Obesity status is a risk factor for secondary surgery after neurolysis, direct nerve repair or nerve grafting in traumatic brachial plexus injury: a retrospective cohort study. 61
32295588 2020
25
Reconstruction of a C7-T1 brachial plexus lower root injury by transferring multiple nerves and a free gracilis muscle: Case report. 61
32187408 2020
26
The Inverted Free Functioning Gracilis Muscle Transfer For Restoration of Elbow Flexion Following Delayed Presentation or Failed Primary Nerve Reconstruction of Upper Trunk Injuries. 61
31343593 2020
27
Is one nerve transfer enough? A systematic review and pooled analysis comparing ulnar fascicular nerve transfer and double ulnar and median fascicular nerve transfer for restoration of elbow flexion after traumatic brachial plexus injury. 61
31755577 2020
28
Outcomes after occupational therapy intervention for traumatic brachial plexus injury: A prospective longitudinal cohort study. 61
32156574 2020
29
Pronator Quadratus to Extensor Carpi Radialis Brevis Nerve Transfer in C5-C7 or C5-C8 Brachial Plexus Injuries for Independent Wrist Extension. 61
32367916 2020
30
Transfer of the peroneal component of the sciatic nerve in total brachial plexus lesion: An anatomical feasibility study. 61
32201119 2020
31
Functional restoration of elbow flexion in nonobstetric brachial plexus injuries: A meta-analysis of nerve transfers versus grafts. 61
31486132 2020
32
Neonatal brachial plexus injuries and their impact on growing bone. An experimental study. 61
32122625 2020
33
The 2-Dimensional and 3-Dimensional Anatomy of the Adult Brachial Plexus Divisions and Cords. 61
32100569 2020
34
Evaluation of Triple Neurotization Technique as a Single Procedure in Adult Traumatic Brachial Plexus Injury. 61
32089969 2020
35
What Range of Motion is Achieved 5 Years After External Rotationplasty of the Shoulder in Infants with an Obstetric Brachial Plexus Injury? 61
31651590 2020
36
EPIDEMIOLOGICAL STUDY OF TRAUMATIC BRACHIAL PLEXUS INJURIES. 61
32095106 2020
37
Diffusion Tensor Imaging for Diagnosing Root Avulsions in Traumatic Adult Brachial Plexus Injuries: A Proof-of-Concept Study. 61
32373625 2020
38
Elbow flexion reconstruction with nerve transfer or grafting in patients with brachial plexus injuries: A systematic review and comparison study. 61
30761593 2020
39
Double-Nerve Transfer to the Axillary Nerve in Traumatic Upper Trunk Brachial Plexus Injuries Using an Axillary Approach: Anatomical Description and Preliminary Case Series. 61
31980828 2020
40
Kinematic profiles during activities of daily living in adults with traumatic brachial plexus injuries. 61
31669918 2019
41
A medicolegal analysis of positioning-related perioperative peripheral nerve injuries occurring between 1996 and 2015. 61
31128482 2019
42
Bionic Upper Limb Reconstruction: A Valuable Alternative in Global Brachial Plexus Avulsion Injuries-A Case Series. 61
31861941 2019
43
Partial ulnar nerve transfer to the branch of the long head of the triceps to recover elbow extension in C5, C6 and C7 brachial plexus palsy. 61
31690498 2019
44
Imaging of the Peripheral Nerve: Concepts and Future Direction of Magnetic Resonance Neurography and Ultrasound. 61
31585745 2019
45
Early Complication of Humeral Derotational Osteotomy Surgery for Obstetric Brachial Plexus as Salvage for a Failed Tendon Transfer. Case Report. 61
32153676 2019
46
Contralateral C7 transfer via both ulnar nerve and medial antebrachial cutaneous nerve to repair total brachial plexus avulsion: a preliminary report. 61
31601135 2019
47
Comparison of spinal accessory nerve transfer to supra-scapular nerve vs. shoulder arthrodesis in adults with brachial plexus injury. 61
31680015 2019
48
Reconstruction of elbow flexion with a modified Oberlin procedure: A comparative study. 61
31668835 2019
49
The Validity, Reliability and Internal Consistency of the Cross-Cultural Adaptation of the FIL-DASH (Filipino Version of the Disability of the Arm, Shoulder and Hand) Questionnaire in Patients with Traumatic Brachial Plexus Injuries. 61
31690189 2019
50
FUNCTIONAL OUTCOME OF OBERLIN PROCEDURE. 61
31798318 2019

Variations for Brachial Plexus Lesion

Expression for Brachial Plexus Lesion

Search GEO for disease gene expression data for Brachial Plexus Lesion.

Pathways for Brachial Plexus Lesion

GO Terms for Brachial Plexus Lesion

Biological processes related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ureteric bud development GO:0001657 8.62 GDNF CRLF1

Sources for Brachial Plexus Lesion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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