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MCID: BRC010
MIFTS: 47

Brachial Plexus Lesion

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Brachial Plexus Lesion

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MalaCards integrated aliases for Brachial Plexus Lesion:

Name: Brachial Plexus Lesion 12 15 74
Brachial Plexus Injuries 55 44
Brachial Plexus Lesions 12

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)
ICD10: 34


External Ids:

Disease Ontology 12 DOID:8443
ICD9CM 36 353.0
SNOMED-CT 69 3548001
ICD10 34 S14.3
UMLS 74 C0006091
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Summaries for Brachial Plexus Lesion

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NINDS : 55 The brachial plexus is a network of nerves that conducts signals from the spine to the shoulder, arm, and hand. Brachial plexus injuries are caused by damage to those nerves. Symptoms may include a limp or paralyzed arm; lack of muscle control in the arm, hand, or wrist; and a lack of feeling or sensation in the arm or hand.  Brachial plexus injuries can occur as a result of shoulder trauma, tumors, or inflammation.  There is a rare syndrome called Parsonage-Turner Syndrome, or brachial plexitis, which causes inflammation of the brachial plexus without any obvious shoulder injury.  This syndrome can begin with severe shoulder or arm pain followed by weakness and numbness. In infants, brachial plexus injuries may happen during birth if the baby’s shoulder is stretched during passage in the birth canal.    The severity of a brachial plexus injury is determined by the type of damage done to the nerves.  The most severe type,avulsion, is caused when the nerve root is severed or cut from the spinal cord.  There is also an incomplete form of avulsion in which part of the nerve is damaged and which leaves some opportunity for the nerve to slowly recover function.  Neuropraxia, or stretch injury, is the mildest type of injury.  Neuropraxia damages the protective covering of the nerve, which causes problems with nerve signal conduction, but does not always damage the nerve underneath.

MalaCards based summary : Brachial Plexus Lesion, also known as brachial plexus injuries, is related to causalgia and non-recovering obstetric brachial plexus lesion. An important gene associated with Brachial Plexus Lesion is SERPINI2 (Serpin Family I Member 2), and among its related pathways/superpathways are Guidance Cues and Growth Cone Motility and G-protein signaling TC21 regulation pathway. The drugs Misoprostol and Antacids have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, skin and brain, and related phenotypes are no effect and behavior/neurological

Disease Ontology : 12 A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus.

MedlinePlus : 44 The brachial plexus is a network of nerves that sends signals from the spine to the shoulder, arm, and hand. Damage to the brachial plexus can cause symptoms such as A limp or paralyzed arm Lack of muscle control in the arm, hand, or wrist Lack of feeling or sensation in the arm or hand Brachial plexus injuries can happen because of shoulder trauma, tumors, or inflammation. Sometimes they happen during childbirth when a baby's shoulders become stuck during delivery and the nerves stretch or tear. Some brachial plexus injuries may heal without treatment. Many children who are injured during birth improve or recover by 3 to 4 months of age. Treatment includes physical therapy and, in some cases, surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 77 A brachial plexus injury (BPI), also known as brachial plexus lesion, is an injury to the brachial... more...

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Related Diseases for Brachial Plexus Lesion

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Diseases related to Brachial Plexus Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 causalgia 29.9 CALCA GDNF TAC1
2 non-recovering obstetric brachial plexus lesion 12.5
3 klumpke paralysis 11.8
4 erb-duchenne and dejerine-klumpke palsies 11.7
5 erb's palsy 11.7
6 peripheral nervous system disease 11.4
7 ulnar neuropathy 10.3 CAMP SERPINI2
8 brachial plexus neuropathy 10.2 CRLF1 SERPINI2 SRPX2 XIRP1
9 prurigo nodularis 10.2 SEMA3A TAC1
10 epicondylitis 10.2 SERPINI2 TAC1
11 neuroma 10.2 CALCA GDNF SEMA3F
12 duodenal somatostatinoma 10.2 CALCA NF1
13 obstructive hydrocephalus 10.1 CRLF1 NF1
14 tolosa-hunt syndrome 10.1 NF1 NLRP3
15 giant cell reparative granuloma 10.1 CALCA NF1
16 burn scar 10.1 CALCA TAC1
17 trigeminal nerve neoplasm 10.1 CRLF1 NF1
18 myofascial pain syndrome 10.1 CAMP TAC1
19 siderosis 10.1
20 horner's syndrome 10.1
21 fetal macrosomia 10.1
22 superficial siderosis 10.1
23 mononeuropathy 10.1 GAL SERPINI2 TAC1
24 neurilemmoma of the fifth cranial nerve 10.1 CRLF1 NF1
25 vasomotor rhinitis 10.1 CALCA TAC1
26 plexopathy 10.1 CAMP CRLF1 NLRP3
27 multiple endocrine neoplasia, type iia 10.1 CALCA GDNF NF1
28 multiple endocrine neoplasia 10.1 CALCA GDNF NF1
29 cerebral artery occlusion 10.0 BDNF GDNF
30 segmental dystonia 10.0 BDNF CAMP
31 constipation 10.0 CALCA GDNF TAC1
32 spondyloarthropathy 1 9.9
33 blood group, colton system 9.9
34 breast cancer 9.9
35 scheuermann disease 9.9
36 bornholm eye disease 9.9
37 nasopharyngeal carcinoma 9.9
38 anxiety 9.9
39 spinal cord injury 9.9
40 scoliosis 9.9
41 quadriplegia 9.9
42 neuritis 9.9
43 endometriosis 9.9
44 complex regional pain syndrome 9.9
45 brachial plexus neuritis 9.9
46 poliomyelitis 9.9
47 brown-sequard syndrome 9.9
48 spondylitis 9.9
49 compartment syndrome 9.9
50 neuropathy 9.9

Graphical network of the top 20 diseases related to Brachial Plexus Lesion:



Diseases related to Brachial Plexus Lesion
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Symptoms & Phenotypes for Brachial Plexus Lesion

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GenomeRNAi Phenotypes related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 AMD1 BDNF CALCA CAMP CRLF1 FLNB

MGI Mouse Phenotypes related to Brachial Plexus Lesion:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.11 BDNF CRLF1 FLNB GAL GDNF NF1
2 cardiovascular system MP:0005385 9.97 FLNB GDNF KCNK6 NF1 NRP1 OXT
3 cellular MP:0005384 9.96 BDNF CAMP FLNB GAL GDNF NF1
4 growth/size/body region MP:0005378 9.93 BDNF FLNB GAL GDNF NF1 NLRP3
5 mortality/aging MP:0010768 9.73 BDNF CAMP CRLF1 FLNB GDNF NF1
6 nervous system MP:0003631 9.4 BDNF CRLF1 FLNB GAL GDNF NF1
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Drugs & Therapeutics for Brachial Plexus Lesion

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Drugs for Brachial Plexus Lesion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Misoprostol Approved Phase 4 59122-46-2 5282381
2 Antacids Phase 4
3 Anti-Ulcer Agents Phase 4
4 Oxytocics Phase 4
5 Gastrointestinal Agents Phase 4
6
Ethanol Approved Phase 3 64-17-5 702
7
Peppermint oil Approved, Investigational Phase 3 8006-90-4
8
Peppermint Approved Phase 3
9
Dronabinol Approved, Illicit Phase 3 1972-08-3 16078
10
Metformin Approved Phase 2, Phase 3,Phase 3 657-24-9 14219 4091
11 Nabiximols Investigational Phase 3 56575-23-6
12 Epidiolex Phase 3
13 Analgesics Phase 3,Not Applicable
14 Peripheral Nervous System Agents Phase 3,Not Applicable
15 Hypoglycemic Agents Phase 2, Phase 3,Phase 3
16 Anesthetics Phase 1, Phase 2,Not Applicable
17
Oxymorphone Approved, Investigational, Vet_approved Not Applicable 76-41-5 5284604
18
Oxycodone Approved, Illicit, Investigational Not Applicable 76-42-6 5284603
19
Morphine Approved, Investigational Not Applicable 57-27-2 5288826
20
Glyburide Approved Not Applicable 10238-21-8 3488
21
Heparin Approved, Investigational Not Applicable 9005-49-6 46507594 772
22 Respiratory System Agents
23 insulin ,Not Applicable
24 Insulin, Globin Zinc ,Not Applicable
25 Narcotics Not Applicable
26 Adjuvants, Anesthesia Not Applicable
27 Central Nervous System Depressants Not Applicable
28 Analgesics, Opioid Not Applicable
29 Calamus Not Applicable
30 calcium heparin Not Applicable

Interventional clinical trials:

(show all 36)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Armeo Spring Pediatric in Obstetric Brachial Plexus Injury Active, not recruiting NCT03780322 Phase 4
2 Cervical Ripening for Obese Women: A Randomized, Comparative Effectiveness Trial Active, not recruiting NCT02639429 Phase 4 Vaginal Misoprostol
3 A Study to Compare Sublingual Cannabis Based Medicine Extracts With Placebo to Treat Brachial Plexus Injury Pain Completed NCT01606189 Phase 3 GW-1000-02;GW-2000-02;Placebo
4 Metformin in Obese Non-diabetic Pregnant Women Completed NCT01273584 Phase 2, Phase 3 Metformin;Placebo
5 Medical Optimization of Management of Type 2 Diabetes Complicating Pregnancy (MOMPOD) Recruiting NCT02932475 Phase 3 Metformin;Placebo
6 Stem Cell Therapy to Improve the Muscle Function of Patients With Partly Denervated Muscles of the Arm Unknown status NCT00755586 Phase 1, Phase 2
7 Cortical Effects of Peripheral Nerve Injury At Birth Unknown status NCT02865317
8 R. I. S. POS. T. A Unknown status NCT01991665 Not Applicable
9 Diabetes Mellitus With Pregnancy in Benisuef Localities Unknown status NCT03169205
10 Push With Lower Uterine Segment Support Unknown status NCT02934516 Not Applicable
11 Surgical Repercussions in Respiratory System in Patients With Post-Traumatic Brachial Plexus Injuries: A Prospective Cohort Study Completed NCT03377712
12 Constraint-induced Movement Therapy for Perinatal Brachial Plexus Injury Completed NCT03765034 Not Applicable
13 Changes in Optic Nerve Sheath Diameter in Response to Various Levels of End Tidal Carbon Dioxide Levels Completed NCT02711774
14 The Surgical Treatment of Total Brachial Plexus Avulsion Injury-A Retrospective Study of 73 Patients Completed NCT03162393
15 ECoG Direct Brain Interface for Individuals With Upper Limb Paralysis Completed NCT01393444 Not Applicable
16 Leap Motion Based Exercises in Upper Extremity Rehabilitation of The Children Completed NCT03078998 Not Applicable
17 NMES Efficacy on Patients With NBPP Completed NCT01999465 Not Applicable
18 Induction of Labour for LGA fœtus in Women Without Insulin-treated Diabetes. Completed NCT03355040
19 A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation) Completed NCT00580294 Not Applicable Oxymorphone
20 Gestational Diabetes Diagnostic Methods Completed NCT01540396 Not Applicable
21 The Effect of Primary Delivery of the Anterior Compared With the Posterior Shoulder on Perineal Trauma: a Randomized Controlled Trial Completed NCT01937546 Not Applicable
22 The Aortic Surgery Cerebral Protection Evaluation (ACE) Randomized CardioLink-3 Trial Completed NCT02554032 Not Applicable
23 Treating Prediabetes in the First Trimester Completed NCT01926457 Not Applicable
24 Brain Computer Interface and Virtual Reality (BCI-VR) for Pain Treatment Recruiting NCT03889353 Not Applicable
25 Somatosensory Evoked Potential (SSEP) Monitoring for Brachial Plexus Injury Recruiting NCT03409536
26 Brachial Plexus Birth Palsy: Reinforcement Paradigm to Augment Recovery Recruiting NCT03886792 Not Applicable
27 Prediction of Fetal Macrosomia by US Recruiting NCT03451838
28 Electronic-personalized Program for Obesity in Pregnancy to Improve Delivery Recruiting NCT02924636 Not Applicable
29 Pregnancy Outcomes and Medical Costs According to Gestational Diabetes Mellitus Diagnostic Criteria Recruiting NCT03421262 Not Applicable
30 Real-time Continuous Glucose Monitoring Recruiting NCT03326232 Not Applicable
31 Comparison of Two Screening Strategies for Gestational Diabetes (GDM2) Active, not recruiting NCT02309138 Not Applicable
32 Sup-ER Protocol RCT Terminated NCT01933438 Not Applicable
33 New Prophylactic Maneuver: the "Pushing" Maneuver, Aiming to Reduce the Risk for Shoulder Dystocia Terminated NCT01297439 Not Applicable
34 Obesity & Pregnancy: Factors Influencing Participation in a Physical Activity and Nutritional Counseling Program Terminated NCT02701426 Not Applicable
35 Incidence of Brachial Plexus Injury After Rotator Cuff Repair With Continuous Interscalene Block Withdrawn NCT01334632 Not Applicable
36 Sup-ER Splint for Children With Birth Related Brachial Plexus Injury Withdrawn NCT01663428 Not Applicable

Search NIH Clinical Center for Brachial Plexus Lesion

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Genetic Tests for Brachial Plexus Lesion

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Anatomical Context for Brachial Plexus Lesion

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MalaCards organs/tissues related to Brachial Plexus Lesion:

42
Spinal Cord, Skin, Brain, Eye, Breast
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Publications for Brachial Plexus Lesion

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Articles related to Brachial Plexus Lesion:

(show top 50) (show all 334)
# Title Authors Year
1
Acute brachial plexus lesion complicating a stun-gun assault. ( 30293883 )
2019
2
My hand in my ear: a phantom limb re-induced by the illusion of body ownership in a patient with a brachial plexus lesion. ( 30488117 )
2019
3
Reflections of patients and therapists on a multidisciplinary rehabilitation programme for persons with brachial plexus injuries. ( 29385821 )
2019
4
Scapular Stabilization Limits Glenohumeral Stretching in Children With Brachial Plexus Injuries. ( 29934088 )
2019
5
Comparison between donor nerves to motorize the free functional gracilis muscle transfer for elbow flexion: Retrospective study of 38 consecutive cases in traumatic adult brachial plexus injuries. ( 30672009 )
2019
6
Restoring movements at the shoulder joint in pan-brachial plexus injuries: Focusing on the complex kinesiology. ( 30688228 )
2019
7
Adult Traumatic Brachial Plexus Injuries. ( 30707114 )
2019
8
Systematic review on outcome of free functioning muscle transfers for elbow flexion in brachial plexus injuries. ( 30722722 )
2019
9
Elbow flexion reconstruction with nerve transfer or grafting in patients with brachial plexus injuries: A systematic review and comparison study. ( 30761593 )
2019
10
Outcomes of single versus double fascicular nerve transfers for restoration of elbow flexion in patients with brachial plexus injuries: a systematic review and meta-analysis. ( 30998656 )
2019
11
Sensibility of the Hand in Children With Conservatively or Surgically Treated Upper Neonatal Brachial Plexus Lesion. ( 30077550 )
2018
12
Phantom limb sensations in the ear of a patient with a brachial plexus lesion. ( 30293692 )
2018
13
A Neglected Cause of Iatrogenic Brachial Plexus Injuries in Psychiatric Patients. ( 28521032 )
2018
14
The diagnostic accuracy of 1.5T magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries. ( 28886666 )
2018
15
Efficient Imaging: Examining the Value of Ultrasound in the Diagnosis of Traumatic Adult Brachial Plexus Injuries, A Systematic Review. ( 29040777 )
2018
16
Diagnostic accuracy of magnetic resonance imaging in post-traumatic brachial plexus injuries: A systematic review. ( 29145043 )
2018
17
Spinal accessory nerve to triceps muscle transfer using long autologous nerve grafts for recovery of elbow extension in traumatic brachial plexus injuries. ( 29219757 )
2018
18
The Vienna psychosocial assessment procedure for bionic reconstruction in patients with global brachial plexus injuries. ( 29298304 )
2018
19
Early nerve repair in traumatic brachial plexus injuries in adults: treatment algorithm and first experiences. ( 29372877 )
2018
20
Magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries: protocol for a systematic review of diagnostic accuracy. ( 29778092 )
2018
21
A Population-Based Assessment of Depression and Anxiety in Patients With Brachial Plexus Injuries. ( 29789186 )
2018
22
Standard neurophysiological studies and motor evoked potentials in evaluation of traumatic brachial plexus injuries - A brief review of the literature. ( 29803407 )
2018
23
Function of the unaffected arms of children with neonatal brachial plexus injuries. ( 29887414 )
2018
24
Importance of the Wrist Extensor Muscle Training: Two Cases of Elbow Flexorplasty following Traumatic Brachial Plexus Injuries. ( 29888017 )
2018
25
USE OF MAGNETIC RESONANCE IMAGING TO DIAGNOSE BRACHIAL PLEXUS INJURIES. ( 29983631 )
2018
26
Epidemiology, etiology, and types of severe adult brachial plexus injuries requiring surgical repair: systematic review and meta-analysis. ( 30014280 )
2018
27
Epidemiological characteristics of surgically treated civilian traumatic brachial plexus injuries in Serbia. ( 30056518 )
2018
28
Successful recovery of sensation loss in upper brachial plexus injuries. ( 30094689 )
2018
29
Phrenic to musculocutaneous nerve transfer for traumatic brachial plexus injuries: analyzing respiratory effects on elbow flexion control. ( 30141757 )
2018
30
An All-Anterior Approach for Quadruple Nerve Transfer for Upper Trunk Brachial Plexus Injuries. ( 30165220 )
2018
31
The Multidisciplinary Approach to the Diagnosis and Management of Nonobstetric Traumatic Brachial Plexus Injuries. ( 30247979 )
2018
32
Obstetric brachial plexus injuries (OBPIs): health-related quality of life in affected adults and parents. ( 30442125 )
2018
33
The Importance of Clinical Examination in Traumatic Brachial Plexus Injuries. ( 30483029 )
2018
34
A hybrid technique of trapezius muscle transfer for a flail shoulder in late brachial plexus injuries. ( 30983740 )
2018
35
Glenoid morphology in obstetrical brachial plexus lesion: a three-dimensional computed tomography study. ( 28412107 )
2017
36
Refinement of myotome values in the upper limb: Evidence from brachial plexus injuries. ( 26409623 )
2017
37
Evaluation of infraspinatus reinnervation and function following spinal accessory nerve to suprascapular nerve transfer in adult traumatic brachial plexus injuries. ( 27206345 )
2017
38
Magnetic Resonance Neurographic and Clinical Long-Term Results After Oberlin's Transfer for Adult Brachial Plexus Injuries. ( 27801698 )
2017
39
The Associated Factors and Clinical Features of Neuropathic Pain After Brachial Plexus Injuries: A Cross-sectional Study. ( 28244945 )
2017
40
Motor and Sensory Cortical Changes after Contralateral Cervical Seventh Nerve Root (CC7) Transfer in Patients with Brachial Plexus Injuries. ( 28506157 )
2017
41
Transfer of the lateral antebrachial cutaneous nerve to the dorsal branch of the ulnar nerve without nerve graft in case of lower brachial plexus injuries: Anatomical and feasibility study. ( 28623105 )
2017
42
Nerve transfer to relieve pain in upper brachial plexus injuries: Does it work? ( 29073501 )
2017
43
The Prevention and Recognition of Ulnar Nerve and Brachial Plexus Injuries. ( 29157770 )
2017
44
Prompt Referral in the Nonoperative Treatment of Obstetrical Brachial Plexus Injuries. ( 29632767 )
2017
45
Unusual brachial plexus lesion: Hematoma masquerading as a peripheral nerve sheath tumor. ( 26904368 )
2016
46
Thoracodorsal nerve transfer for triceps reinnervation in partial brachial plexus injuries. ( 25639376 )
2016
47
Direct Coaptation of the Phrenic Nerve With the Posterior Division of the Lower Trunk to Restore Finger and Elbow Extension Function in Patients With Total Brachial Plexus Injuries. ( 26348009 )
2016
48
Relationship between parity and brachial plexus injuries. ( 26765557 )
2016
49
Double Distal Intraneural Fascicular Nerve Transfers for Lower Brachial Plexus Injuries. ( 26787410 )
2016
50
Adult brachial plexus injuries: Surgical strategies and approaches. ( 26954809 )
2016
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Variations for Brachial Plexus Lesion

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Expression for Brachial Plexus Lesion

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Search GEO for disease gene expression data for Brachial Plexus Lesion.
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Pathways for Brachial Plexus Lesion

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Pathways related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Guidance Cues and Growth Cone Motility 65
11.4 BDNF NRP1 SEMA3A
2
G-protein signaling TC21 regulation pathway 23
Show member pathways
 10.86 NF1 NRP1 SEMA3A
3
Semaphorin Signaling 65
10.45 NF1 NRP1 SEMA3A
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GO Terms for Brachial Plexus Lesion

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Cellular components related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 BDNF CALCA CAMP CRLF1 GAL NRP1
2 axon GO:0030424 9.55 BDNF NF1 NRP1 SEMA3A TAC1
3 extracellular region GO:0005576 9.47 BDNF CALCA CAMP CRLF1 GAL GDNF

Biological processes related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 nervous system development GO:0007399 9.95 BDNF GDNF NRP1 SEMA3A
2 heart development GO:0007507 9.95 NF1 NRP1 OXT XIRP1
3 axon guidance GO:0007411 9.93 BDNF GDNF NRP1 SEMA3A SEMA3F
4 negative regulation of neuron apoptotic process GO:0043524 9.91 BDNF CRLF1 GDNF NRP1
5 positive regulation of synapse assembly GO:0051965 9.82 BDNF OXT SRPX2
6 neural crest cell migration GO:0001755 9.79 GDNF SEMA3A SEMA3F
7 semaphorin-plexin signaling pathway GO:0071526 9.78 NRP1 SEMA3A SEMA3F
8 peripheral nervous system development GO:0007422 9.74 BDNF GDNF NF1
9 negative regulation of axon extension involved in axon guidance GO:0048843 9.73 NRP1 SEMA3A SEMA3F
10 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.7 NRP1 SEMA3A SEMA3F
11 facial nerve structural organization GO:0021612 9.69 NRP1 SEMA3A SEMA3F
12 artery morphogenesis GO:0048844 9.68 NF1 NRP1
13 motor neuron axon guidance GO:0008045 9.68 NRP1 SEMA3A
14 axonal fasciculation GO:0007413 9.68 NRP1 SEMA3A
15 negative regulation of axon extension GO:0030517 9.67 NRP1 SEMA3A
16 neuropeptide signaling pathway GO:0007218 9.67 GAL TAC1
17 sympathetic ganglion development GO:0061549 9.67 NRP1 SEMA3A SEMA3F
18 positive regulation of ossification GO:0045778 9.66 OXT TAC1
19 positive regulation of renal sodium excretion GO:0035815 9.66 OXT TAC1
20 commissural neuron axon guidance GO:0071679 9.65 GDNF NRP1
21 axon extension involved in axon guidance GO:0048846 9.65 NRP1 SEMA3A SEMA3F
22 axonogenesis involved in innervation GO:0060385 9.64 NRP1 SEMA3A
23 dichotomous subdivision of terminal units involved in salivary gland branching GO:0060666 9.63 NRP1 SEMA3A
24 branchiomotor neuron axon guidance GO:0021785 9.63 NRP1 SEMA3A SEMA3F
25 trigeminal ganglion development GO:0061551 9.62 NRP1 SEMA3A
26 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.61 NRP1 SEMA3A SEMA3F
27 basal dendrite arborization GO:0150020 9.6 NRP1 SEMA3A
28 facioacoustic ganglion development GO:1903375 9.59 NRP1 SEMA3A
29 gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 9.58 NRP1 SEMA3A
30 regulation of axon extension involved in axon guidance GO:0048841 9.58 NRP1 SEMA3A
31 trigeminal nerve structural organization GO:0021637 9.58 NRP1 SEMA3A SEMA3F
32 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 9.54 NRP1 SEMA3A SEMA3F
33 sympathetic neuron projection extension GO:0097490 9.5 NRP1 SEMA3A SEMA3F
34 sympathetic neuron projection guidance GO:0097491 9.43 NRP1 SEMA3A SEMA3F
35 response to pain GO:0048265 9.37 TAC1
36 cellular response to peptidoglycan GO:0071224 9.33 NLRP3
37 ventral trunk neural crest cell migration GO:0036486 9.33 NRP1 SEMA3A SEMA3F
38 sympathetic nervous system development GO:0048485 9.26 GDNF NF1 NRP1 SEMA3A
39 nerve development GO:0021675 8.92 BDNF NRP1 SEMA3A SEMA3F
40 regulation of signaling receptor activity GO:0010469 10.02 BDNF CALCA CRLF1 GAL GDNF OXT

Molecular functions related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 semaphorin receptor binding GO:0030215 9.16 SEMA3A SEMA3F
2 neuropilin binding GO:0038191 8.96 SEMA3A SEMA3F
3 hormone activity GO:0005179 8.8 CALCA GAL OXT
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Sources for Brachial Plexus Lesion

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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