MCID: BRC010
MIFTS: 42

Brachial Plexus Lesion

Categories: Neuronal diseases

Aliases & Classifications for Brachial Plexus Lesion

MalaCards integrated aliases for Brachial Plexus Lesion:

Name: Brachial Plexus Lesion 12 15 73
Brachial Plexus Injuries 54 43
Brachial Plexus Lesions 12

Classifications:



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Disease Ontology 12 DOID:8443
ICD9CM 35 353.0
SNOMED-CT 68 3548001
ICD10 33 S14.3
UMLS 73 C0006091

Summaries for Brachial Plexus Lesion

NINDS : 54 The brachial plexus is a network of nerves that conducts signals from the spine to the shoulder, arm, and hand. Brachial plexus injuries are caused by damage to those nerves. Symptoms may include a limp or paralyzed arm; lack of muscle control in the arm, hand, or wrist; and a lack of feeling or sensation in the arm or hand.  Brachial plexus injuries can occur as a result of shoulder trauma, tumors, or inflammation.  There is a rare syndrome called Parsonage-Turner Syndrome, or brachial plexitis, which causes inflammation of the brachial plexus without any obvious shoulder injury.  This syndrome can begin with severe shoulder or arm pain followed by weakness and numbness. In infants, brachial plexus injuries may happen during birth if the baby’s shoulder is stretched during passage in the birth canal.    The severity of a brachial plexus injury is determined by the type of damage done to the nerves.  The most severe type,avulsion, is caused when the nerve root is severed or cut from the spinal cord.  There is also an incomplete form of avulsion in which part of the nerve is damaged and which leaves some opportunity for the nerve to slowly recover function.  Neuropraxia, or stretch injury, is the mildest type of injury.  Neuropraxia damages the protective covering of the nerve, which causes problems with nerve signal conduction, but does not always damage the nerve underneath.

MalaCards based summary : Brachial Plexus Lesion, also known as brachial plexus injuries, is related to causalgia and non-recovering obstetric brachial plexus lesion. An important gene associated with Brachial Plexus Lesion is SERPINI2 (Serpin Family I Member 2), and among its related pathways/superpathways are Guidance Cues and Growth Cone Motility and G-protein signaling TC21 regulation pathway. Affiliated tissues include spinal cord, skin and heart, and related phenotypes are Decreased viability and Decreased viability

Disease Ontology : 12 A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus.

MedlinePlus : 43 The brachial plexus is a network of nerves that sends signals from the spine to the shoulder, arm, and hand. Damage to the brachial plexus can cause symptoms such as A limp or paralyzed arm Lack of muscle control in the arm, hand, or wrist Lack of feeling or sensation in the arm or hand Brachial plexus injuries can happen because of shoulder trauma, tumors, or inflammation. Sometimes they happen during childbirth when a baby's shoulders become stuck during delivery and the nerves stretch or tear. Some brachial plexus injuries may heal without treatment. Many children who are injured during birth improve or recover by 3 to 4 months of age. Treatment includes physical therapy and, in some cases, surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 76 A brachial plexus injury (BPI), also known as brachial plexus lesion, is an injury to the brachial... more...

Related Diseases for Brachial Plexus Lesion

Diseases related to Brachial Plexus Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 causalgia 29.8 CALCA GDNF TAC1
2 non-recovering obstetric brachial plexus lesion 12.4
3 klumpke paralysis 11.7
4 erb-duchenne and dejerine-klumpke palsies 11.7
5 erb's palsy 11.7
6 peripheral nervous system disease 11.4
7 ulnar neuropathy 10.2 CAMP SERPINI2
8 prurigo nodularis 10.2 SEMA3A TAC1
9 epicondylitis 10.1 SERPINI2 TAC1
10 myofascial pain syndrome 10.1 CAMP TAC1
11 brachial plexus neuropathy 10.1 CRLF1 SERPINI2 SRPX2 XIRP1
12 tolosa-hunt syndrome 10.1 NF1 NLRP3
13 mononeuropathy 10.1 GAL SERPINI2 TAC1
14 siderosis 10.1
15 horner's syndrome 10.1
16 fetal macrosomia 10.1
17 superficial siderosis 10.1
18 obstructive hydrocephalus 10.1 CRLF1 NF1
19 plexopathy 10.1 CAMP CRLF1 NLRP3
20 cerebral artery occlusion 10.1 BDNF GDNF
21 segmental dystonia 10.1 BDNF CAMP
22 trigeminal nerve neoplasm 10.1 CRLF1 NF1
23 neurilemmoma of the fifth cranial nerve 10.0 CRLF1 NF1
24 burn scar 10.0 CALCA TAC1
25 neuroma 10.0 CALCA GDNF SEMA3F
26 vasomotor rhinitis 10.0 CALCA TAC1
27 benign epilepsy with centrotemporal spikes 10.0 BDNF CAMP SRPX2
28 duodenal somatostatinoma 10.0 CALCA NF1
29 giant cell reparative granuloma 10.0 CALCA NF1
30 anismus 10.0 CAMP OXT TAC1
31 trigeminal nerve disease 9.9 CRLF1 TAC1
32 constipation 9.9 CALCA GDNF TAC1
33 multiple endocrine neoplasia, type iia 9.9 CALCA GDNF NF1
34 spondyloarthropathy 1 9.9
35 scheuermann disease 9.9
36 anxiety 9.9
37 polyarteritis nodosa, childhood-onset 9.9
38 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 9.9
39 spinal cord injury 9.9
40 quadriplegia 9.9
41 neuritis 9.9
42 endometriosis 9.9
43 complex regional pain syndrome 9.9
44 brachial plexus neuritis 9.9
45 poliomyelitis 9.9
46 spondylitis 9.9
47 compartment syndrome 9.9
48 neuropathy 9.9
49 cerebrospinal fluid leak 9.9
50 superficial siderosis of the central nervous system 9.9

Graphical network of the top 20 diseases related to Brachial Plexus Lesion:



Diseases related to Brachial Plexus Lesion

Symptoms & Phenotypes for Brachial Plexus Lesion

GenomeRNAi Phenotypes related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.05 NF1
2 Decreased viability GR00221-A-2 10.05 NF1
3 Decreased viability GR00221-A-4 10.05 NF1
4 Decreased viability GR00381-A-1 10.05 CALCA CRLF1 SERPINI2
5 Decreased viability GR00402-S-2 10.05 AMD1 BDNF CALCA CAMP CRLF1 GAL
6 no effect GR00402-S-1 9.6 AMD1 BDNF CALCA CAMP CRLF1 GAL

MGI Mouse Phenotypes related to Brachial Plexus Lesion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.85 BDNF CRLF1 GAL GDNF NF1 OXT
2 growth/size/body region MP:0005378 9.7 BDNF GAL GDNF NF1 NLRP3 NRP1
3 nervous system MP:0003631 9.36 BDNF CRLF1 GAL GDNF NF1 NLRP3

Drugs & Therapeutics for Brachial Plexus Lesion

Search Clinical Trials , NIH Clinical Center for Brachial Plexus Lesion

Genetic Tests for Brachial Plexus Lesion

Anatomical Context for Brachial Plexus Lesion

MalaCards organs/tissues related to Brachial Plexus Lesion:

41
Spinal Cord, Skin, Heart

Publications for Brachial Plexus Lesion

Articles related to Brachial Plexus Lesion:

(show top 50) (show all 323)
# Title Authors Year
1
Sensibility of the Hand in Children With Conservatively or Surgically Treated Upper Neonatal Brachial Plexus Lesion. ( 30077550 )
2018
2
Phantom limb sensations in the ear of a patient with a brachial plexus lesion. ( 30293692 )
2018
3
Acute brachial plexus lesion complicating a stun-gun assault. ( 30293883 )
2018
4
My hand in my ear: a phantom limb re-induced by the illusion of body ownership in a patient with a brachial plexus lesion. ( 30488117 )
2018
5
A Neglected Cause of Iatrogenic Brachial Plexus Injuries in Psychiatric Patients. ( 28521032 )
2018
6
The diagnostic accuracy of 1.5T magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries. ( 28886666 )
2018
7
Efficient Imaging: Examining the Value of Ultrasound in the Diagnosis of Traumatic Adult Brachial Plexus Injuries, A Systematic Review. ( 29040777 )
2018
8
Diagnostic accuracy of magnetic resonance imaging in post-traumatic brachial plexus injuries: A systematic review. ( 29145043 )
2018
9
Spinal accessory nerve to triceps muscle transfer using long autologous nerve grafts for recovery of elbow extension in traumatic brachial plexus injuries. ( 29219757 )
2018
10
The Vienna psychosocial assessment procedure for bionic reconstruction in patients with global brachial plexus injuries. ( 29298304 )
2018
11
Early nerve repair in traumatic brachial plexus injuries in adults: treatment algorithm and first experiences. ( 29372877 )
2018
12
Magnetic resonance imaging for detecting root avulsions in traumatic adult brachial plexus injuries: protocol for a systematic review of diagnostic accuracy. ( 29778092 )
2018
13
A Population-Based Assessment of Depression and Anxiety in Patients With Brachial Plexus Injuries. ( 29789186 )
2018
14
Standard neurophysiological studies and motor evoked potentials in evaluation of traumatic brachial plexus injuries - A brief review of the literature. ( 29803407 )
2018
15
Function of the unaffected arms of children with neonatal brachial plexus injuries. ( 29887414 )
2018
16
Importance of the Wrist Extensor Muscle Training: Two Cases of Elbow Flexorplasty following Traumatic Brachial Plexus Injuries. ( 29888017 )
2018
17
Scapular Stabilization Limits Glenohumeral Stretching in Children With Brachial Plexus Injuries. ( 29934088 )
2018
18
USE OF MAGNETIC RESONANCE IMAGING TO DIAGNOSE BRACHIAL PLEXUS INJURIES. ( 29983631 )
2018
19
Epidemiology, etiology, and types of severe adult brachial plexus injuries requiring surgical repair: systematic review and meta-analysis. ( 30014280 )
2018
20
Epidemiological characteristics of surgically treated civilian traumatic brachial plexus injuries in Serbia. ( 30056518 )
2018
21
Successful recovery of sensation loss in upper brachial plexus injuries. ( 30094689 )
2018
22
Phrenic to musculocutaneous nerve transfer for traumatic brachial plexus injuries: analyzing respiratory effects on elbow flexion control. ( 30141757 )
2018
23
An All-Anterior Approach for Quadruple Nerve Transfer for Upper Trunk Brachial Plexus Injuries. ( 30165220 )
2018
24
The Multidisciplinary Approach to the Diagnosis and Management of Nonobstetric Traumatic Brachial Plexus Injuries. ( 30247979 )
2018
25
Obstetric brachial plexus injuries (OBPIs): health-related quality of life in affected adults and parents. ( 30442125 )
2018
26
The Importance of Clinical Examination in Traumatic Brachial Plexus Injuries. ( 30483029 )
2018
27
Glenoid morphology in obstetrical brachial plexus lesion: a three-dimensional computed tomography study. ( 28412107 )
2017
28
Refinement of myotome values in the upper limb: Evidence from brachial plexus injuries. ( 26409623 )
2017
29
Evaluation of infraspinatus reinnervation and function following spinal accessory nerve to suprascapular nerve transfer in adult traumatic brachial plexus injuries. ( 27206345 )
2017
30
Magnetic Resonance Neurographic and Clinical Long-Term Results After Oberlin's Transfer for Adult Brachial Plexus Injuries. ( 27801698 )
2017
31
The Associated Factors and Clinical Features of Neuropathic Pain After Brachial Plexus Injuries: A Cross-sectional Study. ( 28244945 )
2017
32
Motor and Sensory Cortical Changes after Contralateral Cervical Seventh Nerve Root (CC7) Transfer in Patients with Brachial Plexus Injuries. ( 28506157 )
2017
33
Transfer of the lateral antebrachial cutaneous nerve to the dorsal branch of the ulnar nerve without nerve graft in case of lower brachial plexus injuries: Anatomical and feasibility study. ( 28623105 )
2017
34
Nerve transfer to relieve pain in upper brachial plexus injuries: Does it work? ( 29073501 )
2017
35
The Prevention and Recognition of Ulnar Nerve and Brachial Plexus Injuries. ( 29157770 )
2017
36
Prompt Referral in the Nonoperative Treatment of Obstetrical Brachial Plexus Injuries. ( 29632767 )
2017
37
Unusual brachial plexus lesion: Hematoma masquerading as a peripheral nerve sheath tumor. ( 26904368 )
2016
38
Thoracodorsal nerve transfer for triceps reinnervation in partial brachial plexus injuries. ( 25639376 )
2016
39
Direct Coaptation of the Phrenic Nerve With the Posterior Division of the Lower Trunk to Restore Finger and Elbow Extension Function in Patients With Total Brachial Plexus Injuries. ( 26348009 )
2016
40
Relationship between parity and brachial plexus injuries. ( 26765557 )
2016
41
Double Distal Intraneural Fascicular Nerve Transfers for Lower Brachial Plexus Injuries. ( 26787410 )
2016
42
Adult brachial plexus injuries: Surgical strategies and approaches. ( 26954809 )
2016
43
Nerve Transfers in Birth Related Brachial Plexus Injuries: Where Do We Stand? ( 27094890 )
2016
44
Phrenic Nerve Transfer for Reconstruction of Elbow Extension in Severe Brachial Plexus Injuries. ( 27144951 )
2016
45
Severe Brachial Plexus Injuries in American Football. ( 27482729 )
2016
46
Diagnostic Value and Surgical Implications of the 3D DW-SSFP MRI On the Management of Patients with Brachial Plexus Injuries. ( 27782162 )
2016
47
Long-term outcome of accessory nerve to suprascapular nerve transfer in obstetric brachial plexus lesion: functional, morphological, and electrophysiological results. ( 26111514 )
2015
48
Management of infraclavicular (Chuang Level IV) brachial plexus injuries: A single surgeon experience with 75 cases. ( 25294737 )
2015
49
Factors related to the psychosocial functioning of youth with neonatal brachial plexus injuries. ( 25294841 )
2015
50
Results of nerve reconstructions in treatment of obstetrical brachial plexus injuries. ( 25616621 )
2015

Variations for Brachial Plexus Lesion

Expression for Brachial Plexus Lesion

Search GEO for disease gene expression data for Brachial Plexus Lesion.

Pathways for Brachial Plexus Lesion

Pathways related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.4 BDNF NRP1 SEMA3A
2
Show member pathways
10.86 NF1 NRP1 SEMA3A
3 10.45 NF1 NRP1 SEMA3A

GO Terms for Brachial Plexus Lesion

Cellular components related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.73 BDNF CALCA CAMP CRLF1 GAL NRP1
2 axon GO:0030424 9.63 BDNF CALCA NF1 NRP1 SEMA3A TAC1
3 extracellular region GO:0005576 9.47 BDNF CALCA CAMP CRLF1 GAL GDNF

Biological processes related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

(show all 42)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.99 CALCA GAL NLRP3 TAC1
2 heart development GO:0007507 9.95 NF1 NRP1 OXT XIRP1
3 axon guidance GO:0007411 9.93 BDNF GDNF NRP1 SEMA3A SEMA3F
4 negative regulation of neuron apoptotic process GO:0043524 9.91 BDNF CRLF1 GDNF NRP1
5 neuropeptide signaling pathway GO:0007218 9.84 CALCA GAL TAC1
6 positive regulation of synapse assembly GO:0051965 9.82 BDNF OXT SRPX2
7 neural crest cell migration GO:0001755 9.79 GDNF SEMA3A SEMA3F
8 semaphorin-plexin signaling pathway GO:0071526 9.78 NRP1 SEMA3A SEMA3F
9 peripheral nervous system development GO:0007422 9.74 BDNF GDNF NF1
10 negative regulation of axon extension involved in axon guidance GO:0048843 9.73 NRP1 SEMA3A SEMA3F
11 semaphorin-plexin signaling pathway involved in axon guidance GO:1902287 9.7 NRP1 SEMA3A SEMA3F
12 facial nerve structural organization GO:0021612 9.69 NRP1 SEMA3A SEMA3F
13 negative regulation of osteoclast differentiation GO:0045671 9.68 CALCA NF1
14 artery morphogenesis GO:0048844 9.68 NF1 NRP1
15 motor neuron axon guidance GO:0008045 9.68 NRP1 SEMA3A
16 axonal fasciculation GO:0007413 9.68 NRP1 SEMA3A
17 negative regulation of axon extension GO:0030517 9.67 NRP1 SEMA3A
18 response to pain GO:0048265 9.67 CALCA TAC1
19 sympathetic ganglion development GO:0061549 9.67 NRP1 SEMA3A SEMA3F
20 positive regulation of ossification GO:0045778 9.66 OXT TAC1
21 positive regulation of renal sodium excretion GO:0035815 9.66 OXT TAC1
22 commissural neuron axon guidance GO:0071679 9.65 GDNF NRP1
23 axon extension involved in axon guidance GO:0048846 9.65 NRP1 SEMA3A SEMA3F
24 axonogenesis involved in innervation GO:0060385 9.64 NRP1 SEMA3A
25 cellular response to peptidoglycan GO:0071224 9.63 CAMP NLRP3
26 dichotomous subdivision of terminal units involved in salivary gland branching GO:0060666 9.63 NRP1 SEMA3A
27 branchiomotor neuron axon guidance GO:0021785 9.63 NRP1 SEMA3A SEMA3F
28 trigeminal ganglion development GO:0061551 9.62 NRP1 SEMA3A
29 neural crest cell migration involved in autonomic nervous system development GO:1901166 9.61 NRP1 SEMA3A SEMA3F
30 basal dendrite arborization GO:0150020 9.6 NRP1 SEMA3A
31 facioacoustic ganglion development GO:1903375 9.59 NRP1 SEMA3A
32 gonadotrophin-releasing hormone neuronal migration to the hypothalamus GO:0021828 9.58 NRP1 SEMA3A
33 regulation of axon extension involved in axon guidance GO:0048841 9.58 NRP1 SEMA3A
34 trigeminal nerve structural organization GO:0021637 9.58 NRP1 SEMA3A SEMA3F
35 semaphorin-plexin signaling pathway involved in neuron projection guidance GO:1902285 9.54 NRP1 SEMA3A SEMA3F
36 sympathetic neuron projection extension GO:0097490 9.5 NRP1 SEMA3A SEMA3F
37 sympathetic neuron projection guidance GO:0097491 9.43 NRP1 SEMA3A SEMA3F
38 ventral trunk neural crest cell migration GO:0036486 9.33 NRP1 SEMA3A SEMA3F
39 sympathetic nervous system development GO:0048485 9.26 GDNF NF1 NRP1 SEMA3A
40 nerve development GO:0021675 8.92 BDNF NRP1 SEMA3A SEMA3F
41 nervous system development GO:0007399 10.05 BDNF GAL GDNF NRP1 SEMA3A
42 regulation of signaling receptor activity GO:0010469 10.02 BDNF CALCA CRLF1 GAL GDNF OXT

Molecular functions related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 semaphorin receptor binding GO:0030215 9.16 SEMA3A SEMA3F
2 neuropilin binding GO:0038191 8.96 SEMA3A SEMA3F
3 hormone activity GO:0005179 8.8 CALCA GAL OXT

Sources for Brachial Plexus Lesion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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