MCID: BRC010
MIFTS: 33

Brachial Plexus Lesion

Categories: Muscle diseases, Neuronal diseases
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Aliases & Classifications for Brachial Plexus Lesion

MalaCards integrated aliases for Brachial Plexus Lesion:

Name: Brachial Plexus Lesion 11 14 71
Brachial Plexus Injuries 52 41
Brachial Plexus Lesions 11

Classifications:



External Ids:

Disease Ontology 11 DOID:8443
ICD9CM 34 353.0
SNOMED-CT 68 3548001
ICD10 31 S14.3
UMLS 71 C0006091

Summaries for Brachial Plexus Lesion

NINDS: 52 The brachial plexus is a network of nerves that conducts signals from the spine to the shoulder, arm, and hand. Brachial plexus injuries are caused by damage to those nerves. Symptoms may include a limp or paralyzed arm; lack of muscle control in the arm, hand, or wrist; and a lack of feeling or sensation in the arm or hand.  Brachial plexus injuries can occur as a result of shoulder trauma, tumors, or inflammation.  There is a rare syndrome called Parsonage-Turner Syndrome, or brachial plexitis, which causes inflammation of the brachial plexus without any obvious shoulder injury.  This syndrome can begin with severe shoulder or arm pain followed by weakness and numbness. In infants, brachial plexus injuries may happen during birth if the baby’s shoulder is stretched during passage in the birth canal.    The severity of a brachial plexus injury is determined by the type of damage done to the nerves.  The most severe type,avulsion, is caused when the nerve root is severed or cut from the spinal cord.  There is also an incomplete form of avulsion in which part of the nerve is damaged and which leaves some opportunity for the nerve to slowly recover function.  Neuropraxia, or stretch injury, is the mildest type of injury.  Neuropraxia damages the protective covering of the nerve, which causes problems with nerve signal conduction, but does not always damage the nerve underneath.

MalaCards based summary: Brachial Plexus Lesion, also known as brachial plexus injuries, is related to brachial plexus neuropathy and peripheral nervous system disease. An important gene associated with Brachial Plexus Lesion is DCAF8 (DDB1 And CUL4 Associated Factor 8). The drugs Ketamine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and brain.

MedlinePlus: 41 The brachial plexus is a network of nerves that sends signals from the spine to the shoulder, arm, and hand. Damage to the brachial plexus can cause symptoms such as: A limp or paralyzed arm Lack of muscle control in the arm, hand, or wrist Lack of feeling or sensation in the arm or hand Brachial plexus injuries can happen because of shoulder trauma, tumors, or inflammation. Sometimes they happen during childbirth when a baby's shoulders become stuck during delivery and the nerves stretch or tear. Some brachial plexus injuries may heal without treatment. Many children who are injured during birth improve or recover by 3 to 4 months of age. Treatment includes physical therapy and, in some cases, surgery. NIH: National Institute of Neurological Disorders and Stroke

Disease Ontology: 11 A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus.

Related Diseases for Brachial Plexus Lesion

Diseases related to Brachial Plexus Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 brachial plexus neuropathy 32.4 PMP22 DCAF8
2 peripheral nervous system disease 31.5 PMP22 NF1 GDNF DCAF8
3 amyotrophic neuralgia 30.2 PMP22 DCAF8
4 neuritis 30.2 PMP22 GDNF
5 plexopathy 30.2 PMP22 DCAF8
6 neuroma 30.1 SEMA3F NF1 GDNF
7 neuromuscular disease 29.8 PMP22 GDNF DCAF8
8 neurilemmoma 29.6 PMP22 NF1
9 erb-duchenne and dejerine-klumpke palsies 11.6
10 non-recovering obstetric brachial plexus lesion 11.4
11 klumpke paralysis 11.3
12 thoracic outlet syndrome 10.3
13 horner's syndrome 10.2
14 amyotrophy, hereditary neuralgic 10.2
15 meningocele 10.2
16 neuropathy 10.2
17 spinal cord injury 10.2
18 papillon-lefevre syndrome 10.1
19 median neuropathy 10.1 PMP22 DCAF8
20 mononeuritis of upper limb and mononeuritis multiplex 10.1 PMP22 DCAF8
21 ceroid lipofuscinosis, neuronal, 5 10.1
22 muscular atrophy 10.1
23 neurofibroma 10.1
24 hereditary neuropathies 10.1
25 charcot-marie-tooth disease, demyelinating, type 1f 10.1 PMP22 DCAF8
26 chronic inflammatory demyelinating polyradiculoneuropathy 10.1 PMP22 DCAF8
27 oculodentodigital dysplasia 10.0
28 pneumothorax, primary spontaneous 10.0
29 uterine anomalies 10.0
30 ocular motor apraxia 10.0
31 arts syndrome 10.0
32 paine syndrome 10.0
33 anxiety 10.0
34 major depressive disorder 10.0
35 leukemia, acute lymphoblastic 3 10.0
36 b-lymphoblastic leukemia/lymphoma 10.0
37 respiratory failure 10.0
38 quadriplegia 10.0
39 pneumothorax 10.0
40 hemopneumothorax 10.0
41 substance abuse 10.0
42 causalgia 10.0
43 bipolar disorder 10.0
44 brachial plexus neuritis 10.0
45 poliomyelitis 10.0
46 neurotic disorder 10.0
47 nerve compression syndrome 10.0
48 parsonage turner syndrome 10.0
49 central cord syndrome 10.0
50 paresthesia 10.0

Graphical network of the top 20 diseases related to Brachial Plexus Lesion:



Diseases related to Brachial Plexus Lesion

Symptoms & Phenotypes for Brachial Plexus Lesion

Drugs & Therapeutics for Brachial Plexus Lesion

Drugs for Brachial Plexus Lesion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ketamine Approved, Vet_approved Phase 4 6740-88-1, 1867-66-9 3821
2 Anesthetics Phase 4
3 Neurotransmitter Agents Phase 4
4 Excitatory Amino Acid Antagonists Phase 4
5 Anesthetics, Intravenous Phase 4
6 Anesthetics, General Phase 4
7 Anesthetics, Dissociative Phase 4
8 Analgesics Phase 4
9 Respiratory System Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ketamine Infusion for Treatment of Chronic Neuropathic Pain in Traumatic Brachial Plexus Injuries, a Prospective Randomized Control Study Enrolling by invitation NCT04933149 Phase 4 Ketamine Infustion
2 Autologous Bone Marrow Transplantation for Muscle Improvement in Traumatic Brachial Plexus Injuries Unknown status NCT00755586 Phase 1, Phase 2
3 Central Programming in Patients With a Bionic Hand After Traumatic Brachial Plexus Injury Unknown status NCT04649749
4 Novel MRI for Diagnosing Traumatic Brachial Plexus Injuries Unknown status NCT04058821
5 Is Mental Motor Imagery Training Using "GHOST", a Novel BCI-VR Feedback System (Brain Computer Interface and Virtual Reality) Efficient and Safe for Pain Relief in Phantom Limb Pain After Upper Limb Amputation or Brachial Plexus Lesion Completed NCT03889353
6 SURGICAL REPERCUSSIONS IN RESPIRATORY SYSTEM, TRUNK BIOMECHANICAL, FUNCTIONAL CAPACITY AND QUALITY OF LIFE IN PATIENTS WITH POST-TRAUMATIC BRACHIAL PLEXUS INJURIES: A PROSPECTIVE COHORT STUDY Completed NCT03377712
7 Robotic Hand Orthosis Providing Grasp Assistance for Patients With Brachial Plexus Injuries Recruiting NCT04939233
8 EEG as Predictor of Effectiveness of HD-tDCS in Treatment of Neuropathic Pain After Brachial Plexus Injury: Machine Learning Approach Not yet recruiting NCT04852536

Search NIH Clinical Center for Brachial Plexus Lesion

Genetic Tests for Brachial Plexus Lesion

Anatomical Context for Brachial Plexus Lesion

Organs/tissues related to Brachial Plexus Lesion:

MalaCards : Spinal Cord, Bone Marrow, Brain, Bone, Dorsal Root Ganglion, Cortex, Breast

Publications for Brachial Plexus Lesion

Articles related to Brachial Plexus Lesion:

(show top 50) (show all 1469)
# Title Authors PMID Year
1
Obstetric fractures in caesarean delivery and risk factors as evaluated by paediatric surgeons. 41
35982323 2022
2
Neonatal brachial plexus palsy - early diagnosis and treatment. 41
35916611 2022
3
Rucksack palsy after military boot camp. 41
35946714 2022
4
Timing of active phase labor arrest diagnosis in nulliparous women: a cost-effectiveness analysis. 62
33818244 2022
5
Natural History of Brachial Plexus, Peripheral Nerve, and Spinal Schwannomas. 62
36069570 2022
6
A multidisciplinary approach to the management of brachial plexus injuries: experience from the Mayo Clinic over 100 years. 62
35833214 2022
7
Does the magnitude of injuries affect the outcome of proximal humerus fractures treated by locked plating (PHILOS)? 62
32778927 2022
8
Patterns of Nerve Injury and Recovery Rates of Infraclavicular Brachial Plexus Lesions Following Anterior Shoulder Dislocation. 62
34774345 2022
9
Traumatic brachial plexus injury: diagnosis and treatment. 62
36302200 2022
10
An alternate approach: Percutaneous axillary cannulation for minimally invasive cardiac surgery. 62
36423253 2022
11
Free functioning gracilis transfer for brachial plexus reconstruction using the internal mammary vessels as recipients: A case report. 62
36350060 2022
12
Nerve Transfers for Elbow Reconstruction in Upper and Extended Upper-Type Brachial Plexus Injuries: A Case Series. 62
36227251 2022
13
Magnetic Resonance as a Method for Diagnosis for Traumatic Lesions by Brachial Plexus Avulsion. 62
36226224 2022
14
Brachial Plexus Injuries-Where Do We Stand? 62
36337910 2022
15
Patient Characteristics Associated with Operative Treatment for Adult Traumatic Brachial Plexus Injuries at Two Tertiary Referral Hospitals in a Single US Metropolitan Area. 62
36178415 2022
16
Looking through different lenses at neonatal brachial plexus injuries. 62
35451053 2022
17
Iatrogenic nerve injury in primary and revision reverse total shoulder arthroplasty. 62
36245038 2022
18
Diagnostic Accuracy of Magnetic Resonance Imaging With 3-Dimensional T2-SPACE Techniques for Preganglionic Injury of the Brachial Plexus. 62
36041945 2022
19
Anatomic Variations of the Musculocutaneous Nerve and Clinical Implications for Restoration of Elbow Flexion. 62
36064510 2022
20
Long-Term Outcome of 118 Acute Total Brachial Plexus Injury Patients Using Free Vascularized Ulnar Nerve Graft to Innervate the Median Nerve. 62
36191593 2022
21
Clinical, electrophysiological, and imaging findings in childhood brachial plexus injury. 62
35524644 2022
22
Traumatic Brachial Plexus Injury in Indonesia: An Experience from a Developing Country. 62
34470060 2022
23
Brachial plexus lesion induced by tattoo-related lymphadenopathy. 62
35654340 2022
24
Nerve transfers for brachial plexus injuries: grading of volitional control. 62
36115049 2022
25
Clinical Assessment of Functional Recovery Following Nerve Transfer for Traumatic Brachial Plexus Injuries. 62
36231711 2022
26
CORR Insights®: What is the Elbow Flexion Strength After Free Functional Gracilis Muscle Transfer for Adult Traumatic Complete Brachial Plexus Injuries? 62
36099410 2022
27
Discussions About Obstetric Brachial Plexus Injuries. 62
35985757 2022
28
What is the Elbow Flexion Strength After Free Functional Gracilis Muscle Transfer for Adult Traumatic Complete Brachial Plexus Injuries? 62
36001032 2022
29
Traumatic open brachial plexus injuries: The importance of interdisciplinary collaboration. 62
35692810 2022
30
The Role of Amputation and Myoelectric Prosthetic Fitting in Patients with Traumatic Brachial Plexus Injuries. 62
35976186 2022
31
Brachial plexus paralysis in a patient with clavicular fracture, medico-legal implications. 62
36043954 2022
32
An Exploratory Study on Participation Following Brachial Plexus Injury. 62
36018305 2022
33
Evaluation of obstetric management of women with macrosomic foetuses in two Level 3 maternity hospitals in France and identification of predictive factors for obstetric and neonatal complications. 62
35569382 2022
34
The innervation of the biceps brachii and brachialis muscles in specimens with a high incidence of an accessory biceps head. 62
35225060 2022
35
Clinical Application of Diffusion Tensor Imaging for a Brachial Plexus Injury. 62
35885591 2022
36
Fascial manipulation as an adjunct to physiotherapy management in obstetric brachial plexus palsy: A case report. 62
35710218 2022
37
Virtual Reality combined with Robotic facilitated movements for pain management and sensory stimulation of the upper limb following a Brachial Plexus injury: A case study. 62
36176146 2022
38
Comparison of Anterior vs. Dorsal Approach for Spinal Accessory to Suprascapular Nerve Transfer in Patients With a Brachial Plexus Injury and Its Outcome on Shoulder Function. 62
35936186 2022
39
Transhumeral amputation in brachial plexus lesion patients.A multicenter case series. 62
35792322 2022
40
Conservative treatment for brachial plexus injury after a displaced clavicle fracture: a case report and literature review. 62
35780083 2022
41
Validation and Cultural Adaptation of the Serbian Version of the Pediatric Outcome Data Collection Instrument (PODCI) in Children with Obstetrical Brachial Plexus Lesion. 62
35744070 2022
42
Nerve root transfer from C4 to C5 in brachial plexus injuries. Anatomical study and description of the surgical technique. 62
35785132 2022
43
Clinical and functional outcome after different surgical approaches for brachial plexus injuries: Cohort study. 62
35620046 2022
44
Tumor-like disorder of the brachial plexus region in a patient with hemophilia: A case report. 62
35979120 2022
45
Brachial plexus injury: living with uncertainty. 62
35722825 2022
46
The Demography of Traumatic Brachial Plexus Avulsion Injuries. 62
35795508 2022
47
Terminal Anatomy of Phrenic Nerve: A Deeper Look at Diaphragm Innervation Patterns. 62
35077891 2022
48
Factors Impacting the Success of Free Functioning Gracilis Muscle Transfer for Elbow Flexion in Brachial Plexus Reconstruction. 62
35271536 2022
49
Incidence of brachial plexus injury with concurrent subclavian or axillary vascular injury and its influence on reconstruction. 62
35229434 2022
50
Staged Phrenic Nerve Elongation and Free Functional Gracilis Muscle Transplantation-A Possible Option for Late Reconstruction in Chronic Brachial Plexus Injury. 62
35534324 2022

Variations for Brachial Plexus Lesion

Expression for Brachial Plexus Lesion

Search GEO for disease gene expression data for Brachial Plexus Lesion.

Pathways for Brachial Plexus Lesion

GO Terms for Brachial Plexus Lesion

Biological processes related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metanephros development GO:0001656 9.62 NF1 GDNF
2 sympathetic nervous system development GO:0048485 9.46 NF1 GDNF
3 regulation of postsynapse organization GO:0099175 9.43 SEMA3F NF1
4 peripheral nervous system development GO:0007422 9.1 PMP22 NF1 GDNF
5 system development GO:0048731 8.96 SEMA3F GDNF

Sources for Brachial Plexus Lesion

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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