Brachial Plexus Lesion

Categories: Muscle diseases, Neuronal diseases

Aliases & Classifications for Brachial Plexus Lesion

MalaCards integrated aliases for Brachial Plexus Lesion:

Name: Brachial Plexus Lesion 12 15 71
Brachial Plexus Injuries 53 42
Brachial Plexus Lesions 12


External Ids:

Disease Ontology 12 DOID:8443
ICD9CM 34 353.0
SNOMED-CT 67 3548001
ICD10 32 S14.3
UMLS 71 C0006091

Summaries for Brachial Plexus Lesion

NINDS : 53 The brachial plexus is a network of nerves that conducts signals from the spine to the shoulder, arm, and hand. Brachial plexus injuries are caused by damage to those nerves. Symptoms may include a limp or paralyzed arm; lack of muscle control in the arm, hand, or wrist; and a lack of feeling or sensation in the arm or hand.  Brachial plexus injuries can occur as a result of shoulder trauma, tumors, or inflammation.  There is a rare syndrome called Parsonage-Turner Syndrome, or brachial plexitis, which causes inflammation of the brachial plexus without any obvious shoulder injury.  This syndrome can begin with severe shoulder or arm pain followed by weakness and numbness. In infants, brachial plexus injuries may happen during birth if the baby’s shoulder is stretched during passage in the birth canal.    The severity of a brachial plexus injury is determined by the type of damage done to the nerves.  The most severe type,avulsion, is caused when the nerve root is severed or cut from the spinal cord.  There is also an incomplete form of avulsion in which part of the nerve is damaged and which leaves some opportunity for the nerve to slowly recover function.  Neuropraxia, or stretch injury, is the mildest type of injury.  Neuropraxia damages the protective covering of the nerve, which causes problems with nerve signal conduction, but does not always damage the nerve underneath.

MalaCards based summary : Brachial Plexus Lesion, also known as brachial plexus injuries, is related to peripheral nervous system disease and neuroma. An important gene associated with Brachial Plexus Lesion is RHBDD3 (Rhomboid Domain Containing 3). The drugs Ethanol and Dronabinol have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and bone.

Disease Ontology : 12 A brachial plexus neuropathy characterized by an abnormality, usually caused by disease or trauma, located in the brachial plexus.

MedlinePlus : 42 The brachial plexus is a network of nerves that sends signals from the spine to the shoulder, arm, and hand. Damage to the brachial plexus can cause symptoms such as A limp or paralyzed arm Lack of muscle control in the arm, hand, or wrist Lack of feeling or sensation in the arm or hand Brachial plexus injuries can happen because of shoulder trauma, tumors, or inflammation. Sometimes they happen during childbirth when a baby's shoulders become stuck during delivery and the nerves stretch or tear. Some brachial plexus injuries may heal without treatment. Many children who are injured during birth improve or recover by 3 to 4 months of age. Treatment includes physical therapy and, in some cases, surgery. NIH: National Institute of Neurological Disorders and Stroke

Wikipedia : 74 A brachial plexus injury (BPI), also known as brachial plexus lesion, is an injury to the brachial... more...

Related Diseases for Brachial Plexus Lesion

Diseases related to Brachial Plexus Lesion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 peripheral nervous system disease 31.1 PMP22 NF1 GDNF
2 neuroma 29.8 SEMA3F NF1 GDNF
3 klumpke paralysis 11.6
4 erb-duchenne and dejerine-klumpke palsies 11.5
5 non-recovering obstetric brachial plexus lesion 11.3
6 head injury 10.3
7 horner's syndrome 10.2
8 thoracic outlet syndrome 10.2
9 meningocele 10.2
10 chronic pain 10.2
11 spinal cord injury 10.2
12 muscular atrophy 10.1
13 neurofibroma 10.1
14 hereditary neuropathies 10.1
15 uterine anomalies 10.0
16 arts syndrome 10.0
17 anxiety 10.0
18 major affective disorder 8 10.0
19 major affective disorder 9 10.0
20 amyotrophic neuralgia 10.0
21 quadriplegia 10.0
22 pneumothorax 10.0
23 neuritis 10.0
24 hemopneumothorax 10.0
25 substance abuse 10.0
26 causalgia 10.0
27 bipolar disorder 10.0
28 poliomyelitis 10.0
29 parsonage turner syndrome 10.0
30 depression 10.0
31 autonomic dysfunction 10.0
32 central cord syndrome 10.0
33 paresthesia 10.0
34 bicornuate uterus 10.0
35 virus-associated trichodysplasia spinulosa 10.0
36 plexopathy 10.0
37 brachial plexus neuropathy 10.0
38 wallerian degeneration 10.0
39 foot drop 10.0
40 radiation-induced plexopathy 10.0
41 carpal tunnel syndrome 10.0
42 cervical rib 10.0
43 neurofibromatosis, type i 10.0
44 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.0
45 abnormal hair, joint laxity, and developmental delay 10.0
46 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.0
47 cerebral palsy 10.0
48 ankylosis 10.0
49 acute kidney failure 10.0
50 compartment syndrome 10.0

Graphical network of the top 20 diseases related to Brachial Plexus Lesion:

Diseases related to Brachial Plexus Lesion

Symptoms & Phenotypes for Brachial Plexus Lesion

Drugs & Therapeutics for Brachial Plexus Lesion

Drugs for Brachial Plexus Lesion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Ethanol Approved Phase 3 64-17-5 702
Dronabinol Approved, Illicit Phase 3 1972-08-3 16078
Peppermint Approved Phase 3
Peppermint oil Approved, Investigational Phase 3 8006-90-4
5 Nabiximols Investigational Phase 3 56575-23-6
6 Analgesics Phase 3
7 Epidiolex Phase 3
8 Anesthetics Phase 1, Phase 2
9 Respiratory System Agents

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Armeo Spring Pediatric in Children With Narakas I Obstetric Brachial Plexus Injury Active, not recruiting NCT03780322 Phase 4
2 A Double Blind, Randomised, Three Way Crossover Study Comparing Two Different Sublingual Cannabis Based Medicine Extracts With Placebo, in Patients With Chronic Pain Due to Brachial Plexus Injury. Completed NCT01606189 Phase 3 GW-1000-02;GW-2000-02;Placebo
3 Autologous Bone Marrow Transplantation for Muscle Improvement in Traumatic Brachial Plexus Injuries Unknown status NCT00755586 Phase 1, Phase 2
4 Changes in Optic Nerve Sheath Diameter in Response to Various Levels of End Tidal Carbon Dioxide Levels in Healthy Patients Under General Anaesthesia Completed NCT02711774
5 Evaluation of the Diagnostic Threshold of SSEP of Brachial Plexus Injury Completed NCT03409536
6 The Optimal Surgical Strategy for the Treatment of Total Brachial Plexus Avulsion Injury Patients Completed NCT03162393
8 Constraint-Induced Movement Therapy and Occupational Therapy for Perinatal Brachial Plexus Injury: A Randomized Crossover Trial Completed NCT03765034
9 Is Mental Motor Imagery Training Using "GHOST", a Novel BCI-VR Feedback System (Brain Computer Interface and Virtual Reality) Efficient and Safe for Pain Relief in Phantom Limb Pain After Upper Limb Amputation or Brachial Plexus Lesion Recruiting NCT03889353
10 High Frequency Spinal Cord Stimulation for Neuropathic Pain Following Brachial Plexus Avulsion Injury: a Prospective Observational Cohort Study Recruiting NCT04733599
11 Novel MRI for Diagnosing Traumatic Brachial Plexus Injuries Recruiting NCT04058821
12 Clinical Outcomes of Human Amniotic Membrane and Allogeneic Mesenchymal Stem Cells Composite Augmentation for Nerve Transfer Procedure in Brachial Plexus Injury Patients Recruiting NCT04654286
13 A Home-Based Biofeedback Program to Augment Recovery After Perinatal Brachial Plexus Injury Recruiting NCT03886792
14 Central Programming in Patients With a Bionic Hand After Traumatic Brachial Plexus Injury Enrolling by invitation NCT04649749
15 The Effects of Virtual Reality on Upper Extremity in Patients With Obstetric Brachial Plexus Injury Not yet recruiting NCT04605601
16 Does Early Supination and External Rotation Repositioning in Children With Birth Related Brachial Plexus Injury Have Benefit? A Randomized Controlled Trial of the Sup-ER Protocol. Terminated NCT01933438
17 Comparison of Incidence of Brachial Plexus Injury After Rotator Cuff Repair With Continuous Interscalene Block Versus Patient Controlled Analgesia Morphine Withdrawn NCT01334632
18 Sup-ER Splinting: Does Early Passive Positioning in Supination and External Rotation in Children With Birth Related Brachial Plexus Injury Have Benefit? Withdrawn NCT01663428

Search NIH Clinical Center for Brachial Plexus Lesion

Genetic Tests for Brachial Plexus Lesion

Anatomical Context for Brachial Plexus Lesion

MalaCards organs/tissues related to Brachial Plexus Lesion:

Spinal Cord, Bone Marrow, Bone, Cortex, Skin, Breast, Myeloid

Publications for Brachial Plexus Lesion

Articles related to Brachial Plexus Lesion:

(show top 50) (show all 1106)
# Title Authors PMID Year
Reducing the Risk and Impact of Brachial Plexus Injury Sustained From Prone Positioning-A Clinical Commentary. 42 61
32959717 2020
Brachial Plexus Neuropathies During the COVID-19 Pandemic: A Retrospective Case Series of 15 Patients in Critical Care. 42
33395478 2021
Evaluation of Intrinsic Hand Musculature Reinnervation following Supercharge End-to-Side Anterior Interosseous-to-Ulnar Motor Nerve Transfer. 42
32590654 2020
The Middle Trunk Fascicle: A Simple, Effective Nerve Transfer for Suprascapular Nerve in Upper Brachial Plexus Injuries. 61
33559571 2021
Relocating the C5 nerve stump in C5 nerve grafting to prevent iatrogenic phrenic nerve injury. 61
33507373 2021
Free gracilis muscle transfer with ulnar nerve neurotization for elbow flexion restoration. 61
33210168 2021
Long-Term Outcome of Phrenic Nerve Transfer in Brachial Plexus Avulsion Injuries. 61
33346562 2021
The Role of International Traveling Fellowships in Training the Contemporary US Hand Surgeon. 61
32873447 2021
Nerve Graft Length and Recovery of Elbow Flexion Muscle Strength in Patients With Traumatic Brachial Plexus Injuries: Case Series. 61
33609125 2021
Aberrant central plasticity underlying synchronous sensory phenomena in brachial plexus injuries after contralateral cervical seventh nerve transfer. 61
33548117 2021
Diagnostic Accuracy of the Magnetic Resonance Imaging in Adult Post-Ganglionic Brachial Plexus Traumatic Injuries: A Systematic Review and Meta-Analysis. 61
33573175 2021
The role of arm volumes evaluation in the functional outcome and patient satisfaction following surgical repair of the brachial plexus traumatic injuries. 61
32900291 2020
Diagnostic accuracy of imaging studies for diagnosing root avulsions in post-traumatic upper brachial plexus traction injuries in adults. 61
32591949 2020
Transfer of the peroneal component of the sciatic nerve in total brachial plexus lesion: An anatomical feasibility study. 61
32201119 2020
Quality of life of patients with traumatic brachial plexus injuries. 61
33461770 2020
Neonatal brachial plexus injuries and their impact on growing bone. An experimental study. 61
32122625 2020
The Original Cushing Society: A Historical Review of the Senior Society's First 6 Meetings. 61
33307257 2020
Re: Chia DSY et al. Elbow flexion strength and contractile activity after partial ulnar nerve or intercostal nerve transfers for brachial plexus injuries. J Hand Surg Eur. 2020. DOI: 10.1177/1753193420922184. 61
32659141 2020
Approach to the Pan-brachial Plexus Injury: Variation in Surgical Strategies among Surgeons. 61
33299725 2020
Assessment of the relationship between Brachial Plexus Profile activity short form scores and modified Mallet scores. 61
33308927 2020
The extent of brachial plexus injury: an important factor in spinal accessory nerve to suprascapular nerve transfer outcomes. 61
31307250 2020
Pathophysiologic Origins of Brachial Plexus Injury. 61
32925630 2020
Surgical Management of Massive Irreparable Posterosuperior Rotator Cuff Tears: Arthroscopic-Assisted Lower Trapezius Transfer. 61
32661919 2020
Outcomes after occupational therapy intervention for traumatic brachial plexus injury: A prospective longitudinal cohort study. 61
32156574 2020
Elbow flexion strength and contractile activity after partial ulnar nerve or intercostal nerve transfers for brachial plexus injuries. 61
32380918 2020
Considerations For Surgical Approaches To Derotational Humeral Osteotomy In Both Obstetric And Adult Traumatic Brachial Plexus Injuries. 61
33225637 2020
The Effect of Distal Transfer of the Spinal Accessory Nerve to the Suprascapular Nerve on the Shoulder Reanimation in Spontaneously Partially Recovered Obstetric Brachial Plexus Lesion. 61
32472795 2020
Distribution of Peripheral Nerve Injuries in Patients with a History of Shoulder Trauma Referred to a Tertiary Care Electrodiagnostic Laboratory. 61
33143188 2020
Surgical treatment of birth-related brachial plexus injuries: a historical review. 61
32468240 2020
Functional outcome predictors after spinal accessory nerve to suprascapular nerve transfer for restoration of shoulder abduction in traumatic brachial plexus injuries in adults: the effect of time from injury to surgery. 61
32980882 2020
Comparison Between Supraclavicular Versus Video-Assisted Intrathoracic Phrenic Nerve Section for Transfer in Patients With Traumatic Brachial Plexus Injuries: Case Series. 61
32497215 2020
Conventional and Virtual Reality Mirror Therapies in Upper Obstetric Brachial Palsy: A Randomized Pilot Study. 61
32961793 2020
Reconstruction of a C7-T1 brachial plexus lower root injury by transferring multiple nerves and a free gracilis muscle: Case report. 61
32187408 2020
Radial to Axillary Nerve Transfer Outcomes in Shoulder Abduction: A Systematic Review. 61
33133948 2020
Elbow Flexion Reconstruction in Brachial Plexus Avulsion Injuries - Results with Intercostal Nerve and Distal Nerve Transfers. 61
32723044 2020
Does the magnitude of injuries affect the outcome of proximal humerus fractures treated by locked plating (PHILOS)? 61
32778927 2020
The Effect of Age and the Delay before Surgery on the Outcomes of Intercostal Nerve Transfers to the Musculocutaneous Nerve: A Retrospective Study of 232 Cases of Posttraumatic Total and Near-total Brachial Plexus Injuries. 61
32884192 2020
Intercostal Nerve Transfers to the Musculocutaneous-A Reliable Nerve Transfer for Restoration of Elbow Flexion in Birth-Related Brachial Plexus Injuries. 61
32884191 2020
Fabrication of the external rotation abduction thermoplastic shoulder orthosis for infants and children with birth-related brachial plexus injuries. 61
32847697 2020
Double-Nerve Transfer to the Axillary Nerve in Traumatic Upper Trunk Brachial Plexus Injuries Using an Axillary Approach: Anatomical Description and Preliminary Case Series. 61
31980828 2020
Intercostal to musculocutaneous nerve transfer in patients with complete traumatic brachial plexus injuries: case series. 61
32506331 2020
Differences in strength fatigue when using different donors in traumatic brachial plexus injuries. 61
32556814 2020
The Plexogram: A Tool for Understanding and Evaluating Brachial Plexus Injuries. 61
32802673 2020
Shoulder Rotation Function following the Sup-ER Protocol in Children with Brachial Plexus Injuries. 61
32674626 2020
32788856 2020
Combine contrast-enhanced 3D T2-weighted short inversion time inversion recovery MR neurography with MR angiography at 1.5 T in the assessment of brachial plexopathy. 61
32661842 2020
Shoulder Dystocia: Managing an Obstetric Emergency. 61
32667171 2020
Reliability of Various Predictors for Preoperative Diagnosis of Infraclavicular Brachial Plexus Lesions with Shoulder and/or Elbow Paresis. 61
32207120 2020
Role of Early Referral and Surgical Intervention in Brachial Plexus Birth Palsy: Awareness Among Obstetricians and Pediatricians in a Teaching Hospital. 61
31652077 2020
Great Occipital Nerve as Donor Nerve for Neurotization With Suprascapular Nerve in Total Braqchial Plexus Injuries: Nerve Transfer Technique. 61
31764485 2020

Variations for Brachial Plexus Lesion

Expression for Brachial Plexus Lesion

Search GEO for disease gene expression data for Brachial Plexus Lesion.

Pathways for Brachial Plexus Lesion

GO Terms for Brachial Plexus Lesion

Biological processes related to Brachial Plexus Lesion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.43 RHBDD3 NF1 GDNF
2 liver development GO:0001889 9.37 RHBDD3 NF1
3 neural crest cell migration GO:0001755 9.32 SEMA3F GDNF
4 metanephros development GO:0001656 9.16 NF1 GDNF
5 sympathetic nervous system development GO:0048485 8.96 NF1 GDNF
6 peripheral nervous system development GO:0007422 8.8 PMP22 NF1 GDNF

Sources for Brachial Plexus Lesion

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
70 Tocris
72 UMLS via Orphanet
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