MCID: BRC011
MIFTS: 39

Brachial Plexus Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Brachial Plexus Neuropathy

MalaCards integrated aliases for Brachial Plexus Neuropathy:

Name: Brachial Plexus Neuropathy 12 15 17
Brachial Plexus Neuropathies 43 71
Brachial Plexopathy 12 54
Brachial Plexus Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3690
MeSH 43 D020516
NCIt 49 C27194
SNOMED-CT 67 3548001
ICD10 32 G54.0
UMLS 71 C0700251

Summaries for Brachial Plexus Neuropathy

MalaCards based summary : Brachial Plexus Neuropathy, also known as brachial plexus neuropathies, is related to neuropathy and neuritis, and has symptoms including neuralgia An important gene associated with Brachial Plexus Neuropathy is SEPTIN9 (Septin 9), and among its related pathways/superpathways are Shigellosis and Cytoskeleton remodeling_RalA regulation pathway. The drugs Methylprednisolone and Methylprednisolone hemisuccinate have been mentioned in the context of this disorder. Affiliated tissues include breast, spinal cord and thyroid.

Wikipedia : 74 The brachial plexus is a network (plexus) of nerves (formed by the anterior ramus of the lower four... more...

Related Diseases for Brachial Plexus Neuropathy

Diseases related to Brachial Plexus Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 210)
# Related Disease Score Top Affiliating Genes
1 neuropathy 31.6 SEPTIN9 PMP22 MPZ DCAF8
2 neuritis 31.1 SEPTIN9 PMP22 MPZ
3 plexopathy 30.7 PMP22 DCAF8 CD40LG
4 brachial plexus neuritis 30.6 SEPTIN9 CD40LG
5 mononeuropathy 30.4 PMP22 MPZ CD40LG
6 hereditary neuropathies 30.4 PMP22 MPZ
7 nerve compression syndrome 30.3 PMP22 MPZ
8 mononeuritis multiplex 30.2 PMP22 CD40LG
9 polyradiculopathy 30.2 PMP22 CD40LG
10 guillain-barre syndrome 30.2 PMP22 MPZ CD40LG
11 polyneuropathy 30.1 PMP22 MPZ CD40LG
12 bell's palsy 30.0 PMP22 CD40LG
13 chronic inflammatory demyelinating polyradiculoneuropathy 30.0 PMP22 MPZ
14 polyradiculoneuropathy 29.8 PMP22 MPZ CD40LG
15 peripheral nervous system disease 29.8 PMP22 MPZ DCAF8 CD40LG
16 amyotrophic neuralgia 25.3 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
17 amyotrophy, hereditary neuralgic 12.6
18 brachial plexus lesion 11.8
19 breast cancer 10.6
20 thoracic outlet syndrome 10.5
21 horner's syndrome 10.5
22 herpes zoster 10.5
23 venous thoracic outlet syndrome 10.4
24 arterial thoracic outlet syndrome 10.4
25 median neuropathy 10.4 PMP22 DCAF8
26 foot drop 10.4 PMP22 MPZ
27 radiculopathy 10.3
28 chickenpox 10.3
29 neurogenic thoracic outlet syndrome 10.3
30 roussy-levy hereditary areflexic dystasia 10.3 PMP22 MPZ
31 charcot-marie-tooth disease, demyelinating, type 1d 10.3 PMP22 MPZ
32 charcot-marie-tooth disease, axonal, type 2i 10.3 PMP22 MPZ
33 exanthem 10.3
34 scoliosis 10.3
35 osteomyelitis 10.3
36 charcot-marie-tooth disease type x 10.3 PMP22 MPZ
37 charcot-marie-tooth disease, x-linked dominant, 1 10.3 PMP22 MPZ
38 seizures, benign familial neonatal, 1 10.2
39 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 10.2
40 vasculitis 10.2
41 aneurysm 10.2
42 chronic pain 10.2
43 spinal cord injury 10.2
44 radiation-induced plexopathy 10.2
45 neuropathy, hereditary, with liability to pressure palsies 10.2
46 gonadal dysgenesis 10.2
47 turner syndrome 10.2
48 radiation induced brachial plexopathy 10.2
49 charcot-marie-tooth disease, demyelinating, type 1b 10.2 PMP22 MPZ
50 neurofibromatosis, type iv, of riccardi 10.1

Graphical network of the top 20 diseases related to Brachial Plexus Neuropathy:



Diseases related to Brachial Plexus Neuropathy

Symptoms & Phenotypes for Brachial Plexus Neuropathy

UMLS symptoms related to Brachial Plexus Neuropathy:


neuralgia

Drugs & Therapeutics for Brachial Plexus Neuropathy

Drugs for Brachial Plexus Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
2
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
3
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
4 Prednisolone acetate Approved, Vet_approved Phase 4 52-21-1
5
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
6
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
7
Prednisolone hemisuccinate Experimental Phase 4 2920-86-7
8 Methylprednisolone Acetate Phase 4
9
Tocopherol Approved, Investigational Phase 3 1406-66-2, 54-28-4 14986
10
Clodronate Approved, Investigational, Vet_approved Phase 3 10596-23-3 25419
11
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
12
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
13 Tocotrienol Investigational Phase 3 6829-55-6
14 Vitamins Phase 3
15 Trace Elements Phase 3
16 Micronutrients Phase 3
17 Free Radical Scavengers Phase 3
18 Tocopherols Phase 3
19 Platelet Aggregation Inhibitors Phase 3
20 Nutrients Phase 3
21 Tocotrienols Phase 3
22 Vasodilator Agents Phase 3
23 Antioxidants Phase 3
24 Protective Agents Phase 3
25 Phosphodiesterase Inhibitors Phase 3
26 Radiation-Protective Agents Phase 3
27
Pregabalin Approved, Investigational Phase 2 148553-50-8 5486971
28
Calcium Approved, Nutraceutical Phase 2 7440-70-2 271
29 Anti-Anxiety Agents Phase 2
30 Analgesics Phase 2
31 Tranquilizing Agents Phase 2
32 Hormones Phase 2
33 Anticonvulsants Phase 2
34 Psychotropic Drugs Phase 2
35 Calcium, Dietary Phase 2
36 Central Nervous System Depressants Phase 2
37 calcium channel blockers Phase 2
38
Ropivacaine Approved 84057-95-4 71273 175805
39 Anesthetics, Local
40 Anesthetics

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Effectiveness of Armeo Spring Pediatric in Children With Narakas I Obstetric Brachial Plexus Injury Active, not recruiting NCT03780322 Phase 4
2 Comparison of the Efficacy of Corticosteroid Injection and Extracorporeal Shock Wave Therapy (ESWT) in Patients With Carpal Tunnel Syndrome; A Prospective Randomized Controlled Trial Not yet recruiting NCT03792945 Phase 4 local injection
3 Randomized Clinical Trial Evaluating Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy: the PENTOCLO Trial Completed NCT01291433 Phase 3 Pentoxifylline placebo;Pentoxifylline;Tocopherol acetate;Clodronic Acid;Tocopherol placebo;Clodronate placebo
4 Effect of Pregabalin in Patients With Radiotherapy-Related Neuropathic Pain: a Randomized, Double-blind, Placebo-controlled Trial Completed NCT01869569 Phase 2 Pregabalin;Placebo
5 Thoracic Outlet Syndrome: Case Reports and Analysis - Ultrasound Imaging and Pathomechanics of Brachial Plexus Compression Completed NCT01196637
6 Is There a Real Diaphragm-Sparing Nerve Block for Arthroscopic Shoulder Surgery? Completed NCT03195426
7 Dept. of Radiation Oncology, PGIMER, Chandigarh Completed NCT04175821
8 Efficacy of Pulsed Radiofrequency of the Median Nerve Under Ultrasound Guidance in Patients With Carpal Tunnel Syndrome Completed NCT02217293
9 A Pilot Study of Hypofractionated Simultaneous Integrated Boost Radiotherapy in Stage 0, I and III Breast Cancer Patients Recruiting NCT03167359
10 Does Hyperbaric Oxygen Therapy (HBOT) Reduce Pain, Improve Depression and Impact on Patients' Quality of Life for Those Suffering From Late Radiation Tissue Injury? Recruiting NCT02425215
11 A Pilot Trial of Scrambler Therapy for Pain Associated With Pancreas Cancer Withdrawn NCT03707444

Search NIH Clinical Center for Brachial Plexus Neuropathy

Cochrane evidence based reviews: brachial plexus neuropathies

Genetic Tests for Brachial Plexus Neuropathy

Anatomical Context for Brachial Plexus Neuropathy

MalaCards organs/tissues related to Brachial Plexus Neuropathy:

40
Breast, Spinal Cord, Thyroid, Myeloid, Heart, Brain, Lung

Publications for Brachial Plexus Neuropathy

Articles related to Brachial Plexus Neuropathy:

(show top 50) (show all 188)
# Title Authors PMID Year
1
Backpack palsy and other brachial plexus neuropathies in the military population. 61
31925878 2020
2
Somatosensory evoked potential: Preventing brachial plexus injury in transaxillary robotic surgery. 61
30671961 2019
3
Toxoplasma gondii-induced brachial plexus neuropathy after allogeneic hematopoietic stem cell transplantation. 61
31394027 2019
4
Prone position surgery for a professional sumo wrestler with thoracic ossification of the posterior longitudinal ligament resulting in intraoperative brachial plexus injury by hypertrophic pectoral muscles. 61
30777366 2019
5
Brachial plexus neuropathy by hibernoma compression: An unusual presentation of peripheral non-neural sheath nerve tumor and a systematic review of literature. 61
31085864 2019
6
Postoperative complications in living liver donors: A retrospective study, single-center experience in Saudi Arabia. 61
31031372 2019
7
Lumbosacral radiculoplexus neuropathy: Incidence and the association with diabetes mellitus. 61
30760636 2019
8
Radiation-induced brachial plexus neuropathy: A review. 61
30688233 2019
9
Role of surgery in radiation induced brachial plexus neuropathy. 61
30688234 2019
10
Unilateral brachial plexopathy, a rare complication of Mycoplasma pneumoniae infection. 61
29221755 2018
11
Neurolymphomatosis of the Brachial Plexus and its Branches: Case Series and Literature Review. 61
29307326 2018
12
Therapeutic outcome of CT-guided radiofrequency ablation in patients with osteoid osteoma. 61
28429047 2017
13
Clinical impact of magnetic resonance neurography in patients with brachial plexus neuropathies. 61
27558928 2016
14
Postoperative visual loss following dorsal root entry zone rhizotomy: A dreaded complication after a benign procedure. 61
27833493 2016
15
Pediatric Hereditary Neuralgic Amyotrophy: Successful Treatment With Intravenous Immunoglobulin and Insights Into SEPT9 Pathogenesis. 61
28503616 2016
16
Dosimetric analysis of the brachial plexus among patients with breast cancer treated with post-mastectomy radiotherapy to the ipsilateral supraclavicular area: report of 3 cases of radiation-induced brachial plexus neuropathy. 61
25499205 2014
17
Acute brachial plexus neuropathy with involvement of cranial nerves IX, X, XI and XII. 61
23953851 2013
18
Neonatal vocal cord paralysis-an early presentation of hereditary neuralgic amyotrophy due to a mutation in the SEPT9 gene. 61
22981636 2013
19
[Clinical and neuro electrophysiologic study of flail arm syndrome]. 61
23578448 2013
20
Surgical and postpartum hereditary brachial plexus attacks and prophylactic immunotherapy. 61
23042485 2013
21
Exclusive alternating chemotherapy and radiotherapy in nonmetastatic inflammatory breast cancer: 20 years of follow-up. 61
21277101 2012
22
Midterm results of axilloaxillary cardiopulmonary bypass. 61
22360900 2012
23
Bilateral phrenic nerve dysfunction: a late complication of mantle radiation. 61
20838851 2011
24
An unusual case of neuralgic amyotrophy presenting with bilateral phrenic nerve and vocal cord paresis. 61
21490716 2011
25
Septic arthritis presenting as brachial plexus neurophaty. 61
22707581 2011
26
Brachial plexus neuropathy secondary to postoperative prone positioning for macular hole surgery. 61
25389684 2011
27
Phenotypic spectrum of hereditary neuralgic amyotrophy caused by the SEPT9 R88W mutation. 61
20019224 2010
28
Brachial plexus neuropathy resulting from a massively enlarged papillary thyroid carcinoma. 61
19504551 2009
29
Treatment for neonatal neuralgic amyotrophy. 61
18571949 2009
30
Long-term pain, fatigue, and impairment in neuralgic amyotrophy. 61
19254608 2009
31
SEPT9 mutations and a conserved 17q25 sequence in sporadic and hereditary brachial plexus neuropathy. 61
19204161 2009
32
Partial ulnar nerve transfer to the nerve to the biceps for the treatment of brachial plexopathy in metastatic breast carcinoma: case report. 61
19121733 2009
33
Electrophysiologic evidence of polyneuropathy in a cat with signs of bilateral brachial plexus neuropathy. 61
19210244 2009
34
Hypofractionation in radiotherapy. An investigation of injured Swedish women, treated for cancer of the breast. 61
19504371 2009
35
Stereotactic body radiation therapy in centrally and superiorly located stage I or isolated recurrent non-small-cell lung cancer. 61
18954709 2008
36
The role of the musculocutaneous and radial nerves in elbow flexion and forearm supination: a biomechanical study. 61
18443064 2008
37
Saturday night brachial plexus palsy. 61
17972044 2007
38
Idiopathic neuralgic amyotrophy in childhood. 61
17607603 2007
39
Recurrent lymphoma presenting as brachial plexus neuropathy. 61
17308278 2007
40
Cervical rib fracture: an unusual etiology of thoracic outlet syndrome in a child. 61
17627145 2007
41
Radiation-induced brachial plexus neuropathy - aetiopathogenesis, risk factors, differential diagnostics, symptoms and treatment. 61
17357008 2007
42
[Brachial plexus neuropathy (stinger syndrome) occurring in a patient with shoulder laxity]. 61
17483641 2007
43
Brachial plexus injuries after radiotherapy - analysis of 6 cases. 61
17357009 2007
44
Why we consistently use the left donor kidney in living related transplantation: initial experience of right laparoscopic donor nephrectomy and comparison with left nephrectomy. 61
16979970 2006
45
Perinatal brachial plexus palsy. 61
19030261 2006
46
Brachial plexus hypertrophy in chronic inflammatory demyelinating polyradiculoneuropathy. 61
16427285 2006
47
Friday night palsy: an unusual case of brachial plexus neuropathy. 61
16412841 2006
48
Inherited focal, episodic neuropathies: hereditary neuropathy with liability to pressure palsies and hereditary neuralgic amyotrophy. 61
16775374 2006
49
Bilateral isolated phrenic neuropathy causing painless bilateral diaphragmatic paralysis. 61
16275847 2005
50
Scrambler therapy. 61
16012423 2005

Variations for Brachial Plexus Neuropathy

Expression for Brachial Plexus Neuropathy

Search GEO for disease gene expression data for Brachial Plexus Neuropathy.

Pathways for Brachial Plexus Neuropathy

GO Terms for Brachial Plexus Neuropathy

Cellular components related to Brachial Plexus Neuropathy according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 10.35 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
2 cytoskeleton GO:0005856 10.13 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
3 cell projection GO:0042995 10.07 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12
4 synapse GO:0045202 9.99 SEPTIN8 SEPTIN3 SEPTIN11 PMP22 MPZ
5 septin complex GO:0031105 9.97 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
6 cilium GO:0005929 9.93 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12
7 spindle GO:0005819 9.85 SEPTIN7 SEPTIN6 SEPTIN2 SEPTIN12
8 midbody GO:0030496 9.83 SEPTIN7 SEPTIN6 SEPTIN2 SEPTIN12 SEPTIN1
9 synaptic vesicle GO:0008021 9.81 SEPTIN6 SEPTIN5 SEPTIN4 SEPTIN1
10 presynapse GO:0098793 9.77 SEPTIN8 SEPTIN6 SEPTIN3
11 motile cilium GO:0031514 9.77 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12
12 microtubule cytoskeleton GO:0015630 9.77 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
13 kinetochore GO:0000776 9.76 SEPTIN7 SEPTIN6 SEPTIN2
14 stress fiber GO:0001725 9.76 SEPTIN9 SEPTIN7 SEPTIN12 SEPTIN11
15 chromosome, centromeric region GO:0000775 9.75 SEPTIN7 SEPTIN6 SEPTIN2
16 axoneme GO:0005930 9.74 SEPTIN9 SEPTIN7 SEPTIN2
17 condensed chromosome kinetochore GO:0000777 9.73 SEPTIN7 SEPTIN6 SEPTIN2
18 cleavage furrow GO:0032154 9.71 SEPTIN7 SEPTIN6 SEPTIN2 SEPTIN12
19 non-motile cilium GO:0097730 9.67 SEPTIN9 SEPTIN7 SEPTIN2
20 sperm annulus GO:0097227 9.65 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12
21 septin ring GO:0005940 9.44 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4

Biological processes related to Brachial Plexus Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell differentiation GO:0030154 9.93 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12 PMP22
2 cell cycle GO:0007049 9.93 SEPTIN9 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4 SEPTIN3
3 spermatogenesis GO:0007283 9.8 SEPTIN7 SEPTIN6 SEPTIN4 SEPTIN2 SEPTIN12
4 cell division GO:0051301 9.73 SEPTIN9 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4 SEPTIN3
5 cilium assembly GO:0060271 9.62 SEPTIN7 SEPTIN6 SEPTIN2 SEPTIN11
6 protein heterooligomerization GO:0051291 9.54 SEPTIN9 SEPTIN7 SEPTIN11
7 cytoskeleton-dependent cytokinesis GO:0061640 9.44 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
8 positive regulation of non-motile cilium assembly GO:1902857 9.43 SEPTIN9 SEPTIN7
9 regulation of exocytosis GO:0017157 9.43 SEPTIN5 SEPTIN4 SEPTIN1

Molecular functions related to Brachial Plexus Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.09 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
2 GTP binding GO:0005525 9.77 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4
3 structural molecule activity GO:0005198 9.56 SEPTIN7 SEPTIN5 SEPTIN4 MPZ
4 GTPase activity GO:0003924 9.44 SEPTIN9 SEPTIN8 SEPTIN7 SEPTIN6 SEPTIN5 SEPTIN4

Sources for Brachial Plexus Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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