MCID: BRC011
MIFTS: 40

Brachial Plexus Neuropathy

Categories: Neuronal diseases

Aliases & Classifications for Brachial Plexus Neuropathy

MalaCards integrated aliases for Brachial Plexus Neuropathy:

Name: Brachial Plexus Neuropathy 12 30 15 17
Brachial Plexus Neuropathies 45 74
Brachial Plexopathy 12 56
Brachial Plexus Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3690
MeSH 45 D020516
NCIt 51 C27194
SNOMED-CT 69 3548001
ICD10 34 G54.0
UMLS 74 C0700251

Summaries for Brachial Plexus Neuropathy

MalaCards based summary : Brachial Plexus Neuropathy, also known as brachial plexus neuropathies, is related to plexopathy and brachial plexus lesion, and has symptoms including neuralgia An important gene associated with Brachial Plexus Neuropathy is SEPT9 (Septin 9). The drugs Acetylcholine and Botulinum Toxins have been mentioned in the context of this disorder. Affiliated tissues include breast, spinal cord and lung.

Wikipedia : 77 The brachial plexus is a network of nerves formed by the ventral rami of the lower four cervical nerves... more...

Related Diseases for Brachial Plexus Neuropathy

Diseases related to Brachial Plexus Neuropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)
# Related Disease Score Top Affiliating Genes
1 plexopathy 31.7 CRLF1 PMP22
2 brachial plexus lesion 31.0 CRLF1 SERPINI2 SRPX2 XIRP1
3 neuropathy, hereditary, with liability to pressure palsies 29.9 KIF1B PMP22
4 amyotrophic neuralgia 29.3 DNAH17 KIF1B PMP22 SEC14L1 SEPT9
5 radiation induced brachial plexopathy 12.5
6 amyotrophy, hereditary neuralgic 12.5
7 neuropathy 10.9
8 breast cancer 10.4
9 horner's syndrome 10.3
10 herpes zoster 10.3
11 venous thoracic outlet syndrome 10.3
12 arterial thoracic outlet syndrome 10.3
13 neurogenic thoracic outlet syndrome 10.3
14 osteomyelitis 10.3
15 sulfite oxidase deficiency due to molybdenum cofactor deficiency 10.3
16 lung cancer 10.2
17 scoliosis 10.2
18 thoracic outlet syndrome 10.2
19 arthritis 10.1
20 septic arthritis 10.1
21 ulnar neuropathy 10.1 PMP22 SERPINI2
22 multiple sclerosis 10.1
23 west nile virus 10.1
24 polyarteritis nodosa, childhood-onset 10.1
25 metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration 10.1
26 cervical dystonia 10.1
27 thrombosis 10.1
28 henoch-schoenlein purpura 10.1
29 sarcoma 10.1
30 purpura 10.1
31 dystonia 10.1
32 myeloid sarcoma 10.1
33 marek disease 10.1
34 mononeuropathy 10.1 PMP22 SERPINI2
35 neuritis 10.1 PMP22 SEPT9
36 charcot-marie-tooth disease, axonal, type 2d 10.1 KIF1B PMP22
37 charcot-marie-tooth disease, demyelinating, type 1c 10.1 KIF1B PMP22
38 charcot-marie-tooth disease, demyelinating, type 1b 10.0 KIF1B PMP22
39 charcot-marie-tooth disease, axonal, type 2b 10.0 KIF1B PMP22
40 motor peripheral neuropathy 10.0 KIF1B PMP22
41 charcot-marie-tooth disease, demyelinating, type 1a 10.0 KIF1B PMP22
42 charcot-marie-tooth disease, demyelinating, type 1d 10.0 KIF1B PMP22
43 systemic lupus erythematosus 10.0
44 thyroid cancer, nonmedullary, 1 10.0
45 torticollis 10.0
46 arteriovenous fistula 10.0
47 burns 10.0
48 leukemia 10.0
49 lymphoma 10.0
50 ehlers-danlos syndrome 10.0

Graphical network of the top 20 diseases related to Brachial Plexus Neuropathy:



Diseases related to Brachial Plexus Neuropathy

Symptoms & Phenotypes for Brachial Plexus Neuropathy

UMLS symptoms related to Brachial Plexus Neuropathy:


neuralgia

Drugs & Therapeutics for Brachial Plexus Neuropathy

Drugs for Brachial Plexus Neuropathy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved, Investigational Phase 4,Phase 3 51-84-3 187
2 Botulinum Toxins Phase 4,Phase 3
3 Acetylcholine Release Inhibitors Phase 4,Phase 3
4 Cholinergic Agents Phase 4,Phase 3
5 Neurotransmitter Agents Phase 4,Phase 3
6
Pentoxifylline Approved, Investigational Phase 3 6493-05-6 4740
7
Clodronate Approved, Investigational, Vet_approved Phase 3 10596-23-3 25419
8
Tocopherol Approved, Investigational Phase 3 1406-66-2 14986
9
Ibuprofen Approved Phase 2, Phase 3 15687-27-1 3672
10
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3 59-02-9 14985
11 Tocotrienol Investigational Phase 3 6829-55-6
12 Trace Elements Phase 3
13 Vitamins Phase 3
14 Free Radical Scavengers Phase 3
15 Nutrients Phase 3
16 Tocopherols Phase 3
17 Antioxidants Phase 3
18 Vasodilator Agents Phase 3
19 Bone Density Conservation Agents Phase 3,Phase 2
20 Tocotrienols Phase 3
21 Micronutrients Phase 3
22 Platelet Aggregation Inhibitors Phase 3
23 Phosphodiesterase Inhibitors Phase 3
24 Radiation-Protective Agents Phase 3
25 Protective Agents Phase 3
26 Analgesics, Non-Narcotic Phase 2, Phase 3
27 Antirheumatic Agents Phase 2, Phase 3
28 Analgesics Phase 2, Phase 3
29 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
30 Anti-Inflammatory Agents Phase 2, Phase 3
31 Cyclooxygenase Inhibitors Phase 2, Phase 3
32 Anti-Inflammatory Agents, Non-Steroidal Phase 2, Phase 3
33 abobotulinumtoxinA Phase 3
34 Neuromuscular Agents Phase 3
35 Botulinum Toxins, Type A Phase 3
36
Exemestane Approved, Investigational Phase 2 107868-30-4 60198
37
Tamoxifen Approved Phase 2 10540-29-1 2733526
38
Letrozole Approved, Investigational Phase 2 112809-51-5 3902
39
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
40
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
41
Palbociclib Approved, Investigational Phase 2 571190-30-2 11431660 5005498 5330286
42 Antineoplastic Agents, Hormonal Phase 2
43 Hormone Antagonists Phase 2
44 Selective Estrogen Receptor Modulators Phase 2
45 Estrogens Phase 2
46 Estrogen Receptor Modulators Phase 2
47 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
48 Protein Kinase Inhibitors Phase 2
49 Estrogen Receptor Antagonists Phase 2
50 Aromatase Inhibitors Phase 2

Interventional clinical trials:

(show all 33)
# Name Status NCT ID Phase Drugs
1 Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
2 Effectiveness of Armeo Spring Pediatric in Obstetric Brachial Plexus Injury Active, not recruiting NCT03780322 Phase 4
3 Trial of Combined Pentoxifylline-tocopherol-clodronate vs Placebo in Radiation-induced Brachial Plexopathy Completed NCT01291433 Phase 3 Pentoxifylline placebo;Pentoxifylline;Tocopherol acetate;Clodronic Acid;Tocopherol placebo;Clodronate placebo
4 Hypoalgesic Effect of Neural Mobilization Versus Ibuprofen Pharmacologic Treatment Completed NCT02593721 Phase 2, Phase 3 Ibuprofen
5 Effectiveness and Safety of Early Intramuscular Botulinum Toxin Injections to Prevent Shoulder Deformity in Babies With Obstetrical Brachial Plexus Palsy Recruiting NCT03198702 Phase 3 Botulinum toxin type A injection
6 Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer Completed NCT00960999 Phase 2
7 Hypoalgesic Effect of Median Nerve Neural Mobilization Compared to a Controlled Group Completed NCT02596815 Phase 2
8 Hypoalgesic Effect of Neural Mobilization Completed NCT02595294 Phase 2
9 Radiation Therapy in Treating Women With Early Stage Breast Cancer Recruiting NCT00909909 Phase 2
10 Accelerated Radiation Therapy (ART) to the Breast and Nodal Stations Recruiting NCT02917421 Phase 1, Phase 2
11 Radiation Therapy, Palbociclib, and Hormone Therapy in Treating Breast Cancer Patients With Bone Metastasis Recruiting NCT03691493 Phase 2 Anastrozole;Exemestane;Fulvestrant;Letrozole;Palbociclib;Tamoxifen
12 Stereotactic Body Radiation Therapy in Treating Patients With Stage I Non-Small Cell Lung Cancer Active, not recruiting NCT00750269 Phase 1, Phase 2
13 Shorter Course Radiation for the Treatment of Breast Cancer That Has Spread to Lymph Nodes Active, not recruiting NCT02700386 Phase 2
14 Hypofractionated Proton Beam Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With Stage II-III Non-Small Cell Lung Cancer Completed NCT02172846 Phase 1 Paclitaxel;Carboplatin
15 Thoracic Outlet Syndrome: Case Reports and Analysis With Ultrasound Imaging Completed NCT01196637
16 Constraint-induced Movement Therapy for Perinatal Brachial Plexus Injury Completed NCT03765034 Not Applicable
17 NMES Efficacy on Patients With NBPP Completed NCT01999465 Not Applicable
18 Longitudinal Experimental Study on ULNTT and Cervico-Thoracic Spine Motion Patterns Relationship Completed NCT02632357 Not Applicable
19 GRANVIA®-C Cervical Disc Prosthesis Multicenter European Pilot Study Completed NCT01518582
20 Hypofractionated Radiotherapy in Breast Cancer Recruiting NCT03167359 Not Applicable
21 HBOT Late Radiation Tissue Injury Recruiting NCT02425215
22 Short Course Radiation Therapy in Palliative Treatment of Thoracic Cancer Recruiting NCT03804307 Not Applicable
23 Hypofractionated Vs Conventional Fractionated Postmastectomy Radiotherapy for High Risk Breast Cancer Recruiting NCT03856372 Not Applicable
24 Outcome of 15 Versus 5 Fractions in Adjuvant Breast Radiotherapy in Women Over 65 Years Recruiting NCT03121248 Not Applicable
25 Non-Anesthetized Plexus Technique for Infant (BPBP) MRI Evaluation Recruiting NCT03560999
26 Cervicobrachial Neuralgia and Sagital Balance of the Cervical Spine Recruiting NCT03397459
27 Whole Breast + Lymph Node Irradiation: Prone Compared to Supine Position in 15 or 5 Fractions Recruiting NCT03280719 Not Applicable
28 Palliative Hypofractionated Radiotherapy in Advanced Incurable Breast Cancer Active, not recruiting NCT03511781 Not Applicable
29 Deficits of Strength of the Rotator Muscles of the Shoulder in Children Active, not recruiting NCT03440658
30 Does Wearing Tetra-Grip Improve Arm Function in Children Diagnosed With Neonatal Brachial Plexus Palsy? Enrolling by invitation NCT03647761 Not Applicable
31 Neuralgic Amyotrophy: Central Reorganization and Rehabilitation After Peripheral Dysfunction Enrolling by invitation NCT03441347 Not Applicable
32 Sup-ER Protocol RCT Terminated NCT01933438 Not Applicable
33 Sup-ER Splint for Children With Birth Related Brachial Plexus Injury Withdrawn NCT01663428 Not Applicable

Search NIH Clinical Center for Brachial Plexus Neuropathy

Cochrane evidence based reviews: brachial plexus neuropathies

Genetic Tests for Brachial Plexus Neuropathy

Genetic tests related to Brachial Plexus Neuropathy:

# Genetic test Affiliating Genes
1 Brachial Plexus Neuropathy 30

Anatomical Context for Brachial Plexus Neuropathy

MalaCards organs/tissues related to Brachial Plexus Neuropathy:

42
Breast, Spinal Cord, Lung, Bone, Lymph Node, Prostate, Thyroid

Publications for Brachial Plexus Neuropathy

Articles related to Brachial Plexus Neuropathy:

(show top 50) (show all 85)
# Title Authors Year
1
Radiation-induced brachial plexus neuropathy: A review. ( 30688233 )
2019
2
Role of surgery in radiation induced brachial plexus neuropathy. ( 30688234 )
2019
3
Clinical impact of magnetic resonance neurography in patients with brachial plexus neuropathies. ( 27558928 )
2016
4
Dosimetric analysis of the brachial plexus among patients with breast cancer treated with post-mastectomy radiotherapy to the ipsilateral supraclavicular area: report of 3 cases of radiation-induced brachial plexus neuropathy. ( 25499205 )
2014
5
Acute brachial plexus neuropathy with involvement of cranial nerves IX, X, XI and XII. ( 23953851 )
2013
6
Brachial plexus neuropathy secondary to postoperative prone positioning for macular hole surgery. ( 25389684 )
2011
7
Electrophysiologic evidence of polyneuropathy in a cat with signs of bilateral brachial plexus neuropathy. ( 19210244 )
2009
8
Brachial plexus neuropathy resulting from a massively enlarged papillary thyroid carcinoma. ( 19504551 )
2009
9
SEPT9 mutations and a conserved 17q25 sequence in sporadic and hereditary brachial plexus neuropathy. ( 19204161 )
2009
10
Radiation-induced brachial plexus neuropathy - aetiopathogenesis, risk factors, differential diagnostics, symptoms and treatment. ( 17357008 )
2007
11
Recurrent lymphoma presenting as brachial plexus neuropathy. ( 17308278 )
2007
12
Friday night palsy: an unusual case of brachial plexus neuropathy. ( 16412841 )
2006
13
Stent grafting resolved brachial plexus neuropathy due to cervical arteriovenous fistula. ( 15583459 )
2004
14
High dose intravenous immune globulin in the treatment of hereditary recurrent brachial plexus neuropathy. ( 12640095 )
2003
15
Acute sporadic brachial plexus neuropathy. ( 23978864 )
2002
16
Contralateral brachial plexus neuropathy after arthroscopic shoulder surgery. ( 12098130 )
2002
17
Inflammation and neuropathic attacks in hereditary brachial plexus neuropathy. ( 12082044 )
2002
18
Arteritis and brachial plexus neuropathy as delayed complications of radiation therapy. ( 11499827 )
2001
19
Brachial plexus neuropathy as unusual onset of diffuse neurolymphomatosis. ( 11214664 )
2000
20
Recurring brachial plexus neuropathy in a diabetic patient after shoulder surgery and continuous interscalene block. ( 10960400 )
2000
21
Brachial plexus neuropathy. A long-term outcome study. ( 10991813 )
2000
22
Chronic demyelinating hypertrophic brachial plexus neuropathy. ( 10639625 )
2000
23
Herpetic tracheitis and brachial plexus neuropathy in a child with burns. ( 10501325 )
1999
24
Brachial plexus neuropathy: a rare complication of patient positioning during interventional radiologic procedures. ( 10357484 )
1999
25
Brachial plexus neuropathy following mantle radiotherapy. ( 9890543 )
1998
26
Acquired brachial-plexus neuropathy in the neonate: a rare presentation of late-onset group-B streptococcal osteomyelitis. ( 9698064 )
1998
27
Brachial plexus neuropathy after botulinum toxin injection. ( 9339718 )
1997
28
Chronic relapsing brachial plexus neuropathy with persistent conduction block. ( 9324087 )
1997
29
Acute brachial plexus neuropathy as a presenting sign of peripheral nervous system involvement in paraproteinaemia. ( 9188910 )
1997
30
Recurrent brachial plexus neuropathy in a family with subtle dysmorphic features -- a case of hereditary neuralgic amyotrophy. ( 9237508 )
1997
31
Management of radiation-induced brachial plexus neuropathy. Royal College Radiologists. ( 8738825 )
1996
32
Mapping of hereditary neuralgic amyotrophy (familial brachial plexus neuropathy) to distal chromosome 17q. ( 8780104 )
1996
33
Septic arthritis associated with brachial plexus neuropathy. A case report. ( 8550666 )
1996
34
Brachial plexus neuropathy after radiotherapy can be treated by specialist surgeons. ( 8605493 )
1996
35
Immune brachial plexus neuropathy: suggestive evidence for an inflammatory-immune pathogenesis. ( 8614534 )
1996
36
Brachial plexus neuropathy following attempt at subclavian vein catheterization. Case report. ( 8829409 )
1996
37
Brachial plexus neuropathy after radiotherapy for breast cancer. ( 8520378 )
1995
38
Audit of brachial plexus neuropathy following radiotherapy. ( 8845319 )
1995
39
Hereditary neuropathy with liability to pressure palsies and inherited brachial plexus neuropathy--two genetically distinct disorders. ( 7630211 )
1995
40
Postoperative brachial plexus neuropathy after total knee replacement under spinal anaesthesia. ( 7577297 )
1995
41
Brachial plexus neuropathy secondary to septic arthritis and osteomyelitis: report of two cases. ( 7942033 )
1994
42
Anti-peripheral nerve myelin antibodies and terminal activation products of complement in serum of patients with acute brachial plexus neuropathy. ( 8257306 )
1993
43
Brachial plexus neuropathies after advanced laparoscopic surgery. ( 8405536 )
1993
44
Anticoagulant-induced shoulder hematoma producing brachial plexus neuropathy--case reports. ( 1321570 )
1992
45
Brachial plexus neuropathy associated with scrub typhus: report of a case. ( 1352327 )
1992
46
Brachial plexus neuropathy. ( 1848287 )
1991
47
MRI scanning in brachial plexus neuropathy. ( 1667466 )
1991
48
Acute brachial plexus neuropathy secondary to halo-gravity traction in a patient with Ehlers-Danlos syndrome. ( 1851333 )
1991
49
Recurrent brachial plexus neuropathy and giant cell arteritis. ( 2154359 )
1990
50
Radiation-induced brachial plexus neuropathy in breast cancer patients. ( 2261203 )
1990

Variations for Brachial Plexus Neuropathy

Expression for Brachial Plexus Neuropathy

Search GEO for disease gene expression data for Brachial Plexus Neuropathy.

Pathways for Brachial Plexus Neuropathy

GO Terms for Brachial Plexus Neuropathy

Cellular components related to Brachial Plexus Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule GO:0005874 9.13 DNAH17 KIF1B SEPT9
2 stress fiber GO:0001725 8.62 SEPT9 XIRP1

Biological processes related to Brachial Plexus Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 microtubule-based movement GO:0007018 8.62 DNAH17 KIF1B

Molecular functions related to Brachial Plexus Neuropathy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 motor activity GO:0003774 8.96 DNAH17 KIF1B
2 microtubule motor activity GO:0003777 8.62 DNAH17 KIF1B

Sources for Brachial Plexus Neuropathy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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