MCID: BRN008
MIFTS: 32

Brain Compression

Categories: Neuronal diseases

Aliases & Classifications for Brain Compression

MalaCards integrated aliases for Brain Compression:

Name: Brain Compression 12 15
Compression of Brain 72 33

Classifications:



External Ids:

Disease Ontology 12 DOID:11457
ICD9CM 35 348.4
SNOMED-CT 68 46963008
ICD10 33 G93.5
UMLS 72 C0009592

Summaries for Brain Compression

Disease Ontology : 12 A brain disease that is characterized by pressure on the intracranial tissues by an effusion of blood or cerebrospinal fluid, an abscess, a neoplasm, a depressed fracture of the skull, or edema of the brain.

MalaCards based summary : Brain Compression, also known as compression of brain, is related to hemopneumothorax and intracranial hypertension. An important gene associated with Brain Compression is HCCS (Holocytochrome C Synthase), and among its related pathways/superpathways are Endochondral Ossification and Cell adhesion_Plasmin signaling. The drugs Tranexamic Acid and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and pituitary, and related phenotype is homeostasis/metabolism.

Related Diseases for Brain Compression

Graphical network of the top 20 diseases related to Brain Compression:



Diseases related to Brain Compression

Symptoms & Phenotypes for Brain Compression

MGI Mouse Phenotypes related to Brain Compression:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.17 AVP FGF2 HCCS OGN PLAT POLK

Drugs & Therapeutics for Brain Compression

Drugs for Brain Compression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tranexamic Acid Approved Phase 3 1197-18-8 5526
2
tannic acid Approved Phase 3 1401-55-4
3
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
4
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
5 Hemostatics Phase 3
6 Coagulants Phase 3
7 Antifibrinolytic Agents Phase 3
8 diuretics Phase 3
9 Angiotensin-Converting Enzyme Inhibitors Phase 3
10 Antihypertensive Agents Phase 3
11 Calcium, Dietary Phase 3
12 calcium channel blockers Phase 3
13
Turmeric Approved, Experimental, Investigational Early Phase 1
14
Curcumin Approved, Experimental, Investigational Early Phase 1 458-37-7 969516
15 Analgesics, Non-Narcotic Early Phase 1
16 Peripheral Nervous System Agents Early Phase 1
17 Antioxidants Early Phase 1
18 Analgesics Early Phase 1
19 Anti-Inflammatory Agents, Non-Steroidal Early Phase 1
20 Protective Agents Early Phase 1
21 Turmeric extract Early Phase 1
22 Anti-Inflammatory Agents Early Phase 1
23 Antirheumatic Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma. A Double-blind, Placebo-controlled, Multicentre, Randomized Controlled Clinical Trial Recruiting NCT03582293 Phase 3 Tranexamic Acid 500Mg Tablet;Placebo oral capsule
2 China Antihypertensive Trial in Acute Ischemic Stroke II Not yet recruiting NCT03479554 Phase 3
3 Clinical Action of Curcumin/Turmeric in Chronic Subdural Hematoma Recurrence Recruiting NCT03845322 Early Phase 1 Curcumin Pill;Placebo pills
4 Association Between Haptoglobin Genotype and the Development of Perihematomal Edema After Spontaneous Intracerebral Hemorrhage Terminated NCT02054117
5 Preliminary Investigation of ViaShield™ Amnion Patch as an Anti-Adhesive Barrier in Hemicraniectomies Withdrawn NCT03371316

Search NIH Clinical Center for Brain Compression

Genetic Tests for Brain Compression

Anatomical Context for Brain Compression

MalaCards organs/tissues related to Brain Compression:

41
Brain, Bone, Pituitary, Eye, Skin, Thyroid, Cortex

Publications for Brain Compression

Articles related to Brain Compression:

(show top 50) (show all 200)
# Title Authors PMID Year
1
Neurological abnormalities in 97 dogs with detectable pituitary masses. 38
31112462 2019
2
Head of the Bed Down: Paradoxical Management for Paradoxical Herniation. 38
31403093 2019
3
A microfabricated, 3D-sharpened silicon shuttle for insertion of flexible electrode arrays through dura mater into brain. 38
31216526 2019
4
Case-based review: atypical teratoid/rhabdoid tumor. 38
31386032 2019
5
Detection and Evaluation of Intracranial Aneurysms in the Posterior Fossa by Multidetector Computed Tomography Angiography - Comparison with Digital Subtraction Angiography. 38
31143268 2019
6
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. 38
30948807 2019
7
Spontaneous Subdural Hematoma in a Patient with Polycythemia Vera. 38
30780039 2019
8
Prediction of probability of fatality due to brain injury in traffic accidents. 38
31381455 2019
9
Cerebral Edema and Elevated Intracranial Pressure. 38
30516597 2018
10
Nanoscale mechanics of brain abscess: An atomic force microscopy study. 38
29957562 2018
11
Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model. 38
29219760 2018
12
Rapid increase of 'brain-type' transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery. 38
29701803 2018
13
Intracranial Hematopoiesis in Beta Thalassemia: A Case Series. 38
29368108 2018
14
Bone flap elevation for intracranial EEG monitoring: technical note. 38
28946179 2018
15
An extremely rare giant skin cirsoid angioma with brain compression. 38
29507133 2018
16
A Rare Case of Composite Dural Extranodal Marginal Zone Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. 38
29740389 2018
17
Cerebral Arterial Compliance in Traumatic Brain Injury. 38
29492525 2018
18
[Invasive sinonasal papilloma with intracranial invasion: Case report and bibliographic review]. 38
29430328 2018
19
Brain metastasis: clinical manifestations, symptom management, and palliative care. 38
29307363 2018
20
Hyponatremia and the Brain. 38
29340311 2018
21
Calcified cephalohematoma as an unusual cause of EEG anomalies: case report. 38
27715482 2017
22
Development of acute hydrocephalus does not change brain tissue mechanical properties in adult rats, but in juvenile rats. 38
28837671 2017
23
To Retain or Remove the Bone Flap During Evacuation of Acute Subdural Hematoma: Factors Associated with Perioperative Brain Edema. 38
27476687 2016
24
Density measurements with computed tomography in patients with extra-axial hematoma can quantitatively estimate a degree of brain compression. 38
27385774 2016
25
Early Decompression of Acute Subdural Hematoma for Postoperative Neurological Improvement: A Single Center Retrospective Review of 10 Years. 38
27182496 2016
26
Calvarial bone cavernous hemangioma with intradural invasion: An unusual aggressive course-Case report and literature review. 38
27061482 2016
27
[Extensive cranioplasty for sagittal synostosis in young children by preserving multiple cranial bone flaps adhered to the dura mater: experience with 63 cases]. 38
27197472 2016
28
Improving hospital death certification in Viet Nam: results of a pilot study implementing an adapted WHO hospital death report form in two national hospitals. 38
28588910 2016
29
Outcome of surgery for operable supratentorial mass lesions in patients presenting with decerebration following severe head injury: A retrospective analysis of factors affecting outcome. 38
26396598 2015
30
Candida Albicans Dural Granuloma: Case Report. 38
28663966 2015
31
Extensive cranioplasty for sagittal synostosis in young children by preserving cranial bone flaps adhered to the dura mater. 38
25668119 2015
32
Outcome of 12 antenatally diagnosed fetal arachnoid cysts: case series and review of the literature. 38
25599983 2015
33
Detection of third and sixth cranial nerve palsies with a novel method for eye tracking while watching a short film clip. 38
25495739 2015
34
Neural oscillation, network, eloquent cortex and epileptogenic zone revealed by magnetoencephalography and awake craniotomy. 38
25685205 2014
35
[Postmortem assessment of labor from changes in the skull and brain in fetuses and newborn infants]. 38
25306615 2014
36
Zolpidem arouses patients in vegetative state after brain injury: quantitative evaluation and indications. 38
23462249 2014
37
Chronic subdural hematoma in elderly patient with EDTA-dependent pseudothrombocytopenia recently treated with aspirin and warfarin: case report. 38
24477063 2014
38
Endoscopic surgery for traumatic acute subdural hematoma. 38
24659965 2013
39
Extracranial expansion of a feline meningioma. 38
23295269 2013
40
Observations of changes of blood pressure before and after neurosurgical decompression in hypertensive patients with different types of neurovascular compression of brain stem. 38
24247558 2013
41
Determination of friction coefficient in unconfined compression of brain tissue. 38
23026694 2012
42
Posterior cranial vault expansion in the treatment of craniosynostosis. Comparison of current techniques. 38
22872270 2012
43
Atypical scaphocephaly: a review. 38
22872243 2012
44
Quantitative immunohistochemical analysis of human brain basic fibroblast growth factor, glial fibrillary acidic protein and single-stranded DNA expressions following traumatic brain injury. 38
22607979 2012
45
Elevated diffusion anisotropy in gray matter and the degree of brain compression. 38
22680241 2012
46
[Intracranial, cerebral perfusion pressure and systemic hemodynamic parameters during anesthesia induction in patients with traumatic brain compression]. 38
23082647 2012
47
[Syndrome of brain compression in cranio-cerebral trauma]. 38
23488267 2012
48
Microscopic magnetic resonance elastography of traumatic brain injury model. 38
21871490 2011
49
Intradiploic epidermoid cyst of the temporal bone: is it the same as or different from cholesteatoma? 38
21959487 2011
50
Automatic measurement of midline shift on deformed brains using multiresolution binary level set method and Hough transform. 38
21722887 2011

Variations for Brain Compression

Expression for Brain Compression

Search GEO for disease gene expression data for Brain Compression.

Pathways for Brain Compression

Pathways related to Brain Compression according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.77 PLAT FGF2
2 10.31 PLAT FGF2

GO Terms for Brain Compression

Cellular components related to Brain Compression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.62 PLAT AVP

Sources for Brain Compression

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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