MCID: BRN008
MIFTS: 29

Brain Compression

Categories: Neuronal diseases

Aliases & Classifications for Brain Compression

MalaCards integrated aliases for Brain Compression:

Name: Brain Compression 12 15
Compression of Brain 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11457
ICD9CM 34 348.4
SNOMED-CT 67 46963008
ICD10 32 G93.5
UMLS 71 C0009592

Summaries for Brain Compression

Disease Ontology : 12 A brain disease that is characterized by pressure on the intracranial tissues by an effusion of blood or cerebrospinal fluid, an abscess, a neoplasm, a depressed fracture of the skull, or edema of the brain.

MalaCards based summary : Brain Compression, also known as compression of brain, is related to intracranial hypertension and thoracic outlet syndrome. An important gene associated with Brain Compression is DNAH14 (Dynein Axonemal Heavy Chain 14). The drugs tannic acid and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and pituitary.

Related Diseases for Brain Compression

Diseases related to Brain Compression via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 intracranial hypertension 9.9
2 thoracic outlet syndrome 9.9 WRNIP1 SDSL
3 moyamoya disease 1 9.9
4 brain edema 9.9
5 actinomycosis 9.7 WRNIP1 HCCS
6 hydrocephalus, congenital, 1 9.6
7 hypervitaminosis a 9.6
8 ocular motor apraxia 9.6
9 meningioma, radiation-induced 9.6
10 meningioma, familial 9.6
11 disseminated intravascular coagulation 9.6
12 spinal meningioma 9.6
13 secretory meningioma 9.6
14 lymphoplasmacyte-rich meningioma 9.6
15 48,xyyy 9.6
16 paresthesia 9.6

Comorbidity relations with Brain Compression via Phenotypic Disease Network (PDN):


Brain Edema Hypertension, Essential
Obstructive Hydrocephalus

Graphical network of the top 20 diseases related to Brain Compression:



Diseases related to Brain Compression

Symptoms & Phenotypes for Brain Compression

Drugs & Therapeutics for Brain Compression

Drugs for Brain Compression (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
tannic acid Approved Phase 3 1401-55-4
2
Benzocaine Approved, Investigational Phase 3 94-09-7, 1994-09-7 2337
3
Tranexamic Acid Approved Phase 3 1197-18-8 5526
4 Antihypertensive Agents Phase 3
5 Angiotensin-Converting Enzyme Inhibitors Phase 3
6 diuretics Phase 3
7 Calcium, Dietary Phase 3
8 calcium channel blockers Phase 3
9 Hemostatics Phase 3
10 Antifibrinolytic Agents Phase 3
11 Coagulants Phase 3
12
Calcium Nutraceutical Phase 3 7440-70-2 271
13
Curcumin Approved, Experimental, Investigational Early Phase 1 458-37-7 969516
14
Turmeric Approved, Experimental, Investigational Early Phase 1
15 Analgesics, Non-Narcotic Early Phase 1
16 Analgesics Early Phase 1
17 Anti-Inflammatory Agents Early Phase 1
18 Turmeric extract Early Phase 1
19 Antirheumatic Agents Early Phase 1
20 Anti-Inflammatory Agents, Non-Steroidal Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 China Antihypertensive Trial in Acute Ischemic Stroke II Recruiting NCT03479554 Phase 3
2 Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma. A Double-blind, Placebo-controlled, Multicentre, Randomized Controlled Clinical Trial Recruiting NCT03582293 Phase 3 Tranexamic Acid 500Mg Tablet;Placebo oral capsule
3 Clinical Action of Curcumin/Turmeric in Chronic Subdural Hematoma Recurrence Recruiting NCT03845322 Early Phase 1 Curcumin Pill;Placebo pills
4 Association Between Haptoglobin Genotype and the Development of Perihematomal Edema After Spontaneous Intracerebral Hemorrhage Terminated NCT02054117
5 Preliminary Investigation of ViaShield™ Amnion Patch as an Anti-Adhesive Barrier in Hemicraniectomies Withdrawn NCT03371316

Search NIH Clinical Center for Brain Compression

Genetic Tests for Brain Compression

Anatomical Context for Brain Compression

MalaCards organs/tissues related to Brain Compression:

40
Brain, Bone, Pituitary, Eye, Cortex, Thyroid, Skin

Publications for Brain Compression

Articles related to Brain Compression:

(show top 50) (show all 205)
# Title Authors PMID Year
1
Craniectomy size for subdural haematomas and the impact on brain shift and outcomes. 61
32556813 2020
2
Letter to the Editor Regarding "Brain Compression by Encephalo-Myo-Synangiosis Is a Risk Factor for Transient Neurological Deficits After Surgical Revascularization in Pediatric Patients with Moyamoya Disease". 61
32204294 2020
3
In Reply to the Letter to the Editor Regarding "Brain Compression by Encephalo-Myo-Synangiosis is a Risk Factor for Transient Neurological Deficits After Surgical Revascularization in Pediatric Patients with Moyamoya Disease". 61
32204295 2020
4
Spontaneous rupture of middle fossa arachnoid cysts: surgical series from a single center pediatric hospital and literature review. 61
32206869 2020
5
Brain Compression by Encephalo-Myo-Synangiosis is a Risk Factor for Transient Neurological Deficits After Surgical Revascularization in Pediatric Patients with Moyamoya Disease. 61
31562963 2020
6
Neurological abnormalities in 97 dogs with detectable pituitary masses. 61
31112462 2019
7
A microfabricated, 3D-sharpened silicon shuttle for insertion of flexible electrode arrays through dura mater into brain. 61
31216526 2019
8
Head of the Bed Down: Paradoxical Management for Paradoxical Herniation. 61
31403093 2019
9
Spontaneous Subdural Hematoma in Patient with Polycythemia Vera. 61
30780039 2019
10
Case-based review: atypical teratoid/rhabdoid tumor. 61
31386032 2019
11
Detection and Evaluation of Intracranial Aneurysms in the Posterior Fossa by Multidetector Computed Tomography Angiography - Comparison with Digital Subtraction Angiography. 61
31143268 2019
12
Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. 61
30948807 2019
13
Prediction of probability of fatality due to brain injury in traffic accidents. 61
31381455 2019
14
Cerebral Edema and Elevated Intracranial Pressure. 61
30516597 2018
15
Direct visualization of microcirculation impairment after acute subdural hemorrhage in a novel animal model. 61
29219760 2018
16
Nanoscale mechanics of brain abscess: An atomic force microscopy study. 61
29957562 2018
17
Rapid increase of 'brain-type' transferrin in cerebrospinal fluid after shunt surgery for idiopathic normal pressure hydrocephalus: a prognosis marker for cognitive recovery. 61
29701803 2018
18
Intracranial Hematopoiesis in Beta Thalassemia: A Case Series. 61
29368108 2018
19
Bone flap elevation for intracranial EEG monitoring: technical note. 61
28946179 2018
20
An extremely rare giant skin cirsoid angioma with brain compression. 61
29507133 2018
21
A Rare Case of Composite Dural Extranodal Marginal Zone Lymphoma and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. 61
29740389 2018
22
Cerebral Arterial Compliance in Traumatic Brain Injury. 61
29492525 2018
23
[Invasive sinonasal papilloma with intracranial invasion: Case report and bibliographic review]. 61
29430328 2018
24
Brain metastasis: clinical manifestations, symptom management, and palliative care. 61
29307363 2018
25
Hyponatremia and the Brain. 61
29340311 2018
26
Calcified cephalohematoma as an unusual cause of EEG anomalies: case report. 61
27715482 2017
27
Development of acute hydrocephalus does not change brain tissue mechanical properties in adult rats, but in juvenile rats. 61
28837671 2017
28
To Retain or Remove the Bone Flap During Evacuation of Acute Subdural Hematoma: Factors Associated with Perioperative Brain Edema. 61
27476687 2016
29
Density measurements with computed tomography in patients with extra-axial hematoma can quantitatively estimate a degree of brain compression. 61
27385774 2016
30
Early Decompression of Acute Subdural Hematoma for Postoperative Neurological Improvement: A Single Center Retrospective Review of 10 Years. 61
27182496 2016
31
Calvarial bone cavernous hemangioma with intradural invasion: An unusual aggressive course-Case report and literature review. 61
27061482 2016
32
[Extensive cranioplasty for sagittal synostosis in young children by preserving multiple cranial bone flaps adhered to the dura mater: experience with 63 cases]. 61
27197472 2016
33
Improving hospital death certification in Viet Nam: results of a pilot study implementing an adapted WHO hospital death report form in two national hospitals. 61
28588910 2016
34
Outcome of surgery for operable supratentorial mass lesions in patients presenting with decerebration following severe head injury: A retrospective analysis of factors affecting outcome. 61
26396598 2015
35
Candida Albicans Dural Granuloma: Case Report. 61
28663966 2015
36
Extensive cranioplasty for sagittal synostosis in young children by preserving cranial bone flaps adhered to the dura mater. 61
25668119 2015
37
Outcome of 12 antenatally diagnosed fetal arachnoid cysts: case series and review of the literature. 61
25599983 2015
38
Detection of third and sixth cranial nerve palsies with a novel method for eye tracking while watching a short film clip. 61
25495739 2015
39
Neural oscillation, network, eloquent cortex and epileptogenic zone revealed by magnetoencephalography and awake craniotomy. 61
25685205 2014
40
[Postmortem assessment of labor from changes in the skull and brain in fetuses and newborn infants]. 61
25306615 2014
41
Zolpidem arouses patients in vegetative state after brain injury: quantitative evaluation and indications. 61
23462249 2014
42
Chronic subdural hematoma in elderly patient with EDTA-dependent pseudothrombocytopenia recently treated with aspirin and warfarin: case report. 61
24477063 2014
43
Endoscopic surgery for traumatic acute subdural hematoma. 61
24659965 2013
44
Extracranial expansion of a feline meningioma. 61
23295269 2013
45
Observations of changes of blood pressure before and after neurosurgical decompression in hypertensive patients with different types of neurovascular compression of brain stem. 61
24247558 2013
46
Determination of friction coefficient in unconfined compression of brain tissue. 61
23026694 2012
47
Atypical scaphocephaly: a review. 61
22872243 2012
48
Posterior cranial vault expansion in the treatment of craniosynostosis. Comparison of current techniques. 61
22872270 2012
49
Quantitative immunohistochemical analysis of human brain basic fibroblast growth factor, glial fibrillary acidic protein and single-stranded DNA expressions following traumatic brain injury. 61
22607979 2012
50
Elevated diffusion anisotropy in gray matter and the degree of brain compression. 61
22680241 2012

Variations for Brain Compression

Expression for Brain Compression

Search GEO for disease gene expression data for Brain Compression.

Pathways for Brain Compression

GO Terms for Brain Compression

Biological processes related to Brain Compression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 8.92 LHX1 HCCS GREM2 APLP1

Molecular functions related to Brain Compression according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.17 WRNIP1 POLK NT5C3A LHX1 HCCS CASZ1

Sources for Brain Compression

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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