Aliases & Classifications for Brain Edema

MalaCards integrated aliases for Brain Edema:

Name: Brain Edema 12 56 45 15 17 74
Intracranial Swelling 12
Cerebral Edema 74
Wet Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4724
MeSH 45 D001929
SNOMED-CT 69 2032001 85974009

Summaries for Brain Edema

Disease Ontology : 12 A brain disease that is characterized by excess accumulation of fluid in the intracellular and/or extracellular spaces of the brain, has symptom nausea, has symptom vomiting, has symptom blurred vision, has symptom seizure, has symptom coma.

MalaCards based summary : Brain Edema, also known as intracranial swelling, is related to traumatic brain injury and intracranial hypertension, and has symptoms including vomiting, coma and blurred vision. An important gene associated with Brain Edema is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Pathways in cancer and Selenium Micronutrient Network. The drugs Temozolomide and Mannitol have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 77 Cerebral edema is excess accumulation of fluid (edema) in the intracellular or extracellular spaces of... more...

Related Diseases for Brain Edema

Diseases related to Brain Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 traumatic brain injury 31.0 AQP4 GFAP IL6
2 intracranial hypertension 30.5 AQP1 AQP4 IL1B
3 ischemia 30.3 GFAP HMOX1 KNG1 SOD1 VEGFA
4 meningitis 30.3 ALB IL1B IL6 MMP9
5 arteriovenous malformation 30.1 IL6 MMP9 VEGFA
6 hepatic encephalopathy 30.0 ALB GLUL IL6 SLC1A2 SLC25A13
7 cerebral hemorrhage 29.9 GFAP IL1B
8 peripheral nervous system disease 29.7 ALB AQP4 IL6
9 bacterial meningitis 29.7 ALB IL1B IL6 MMP9
10 arteriovenous fistula 29.6 HMOX1 IL6
11 burns 29.5 ALB IL1B
12 malaria 29.4 ALB HMOX1 IL1B IL6 MMP9 VEGFA
13 encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy 12.5
14 encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy, 2 12.4
15 citrullinemia, type ii, adult-onset 11.1
16 encephalopathy, acute, infection-induced 4 11.1
17 mitochondrial complex i deficiency, nuclear type 20 10.9
18 brain injury 10.6
19 hemorrhage, intracerebral 10.5
20 acute liver failure 10.5
21 infantile liver failure syndrome 1 10.4
22 encephalopathy 10.4
23 severe nonproliferative diabetic retinopathy 10.4 ALB VEGFA
24 cerebral artery occlusion 10.3
25 angiokeratoma circumscriptum 10.3 MMP9 VEGFA
26 obstructive jaundice 10.3 ALB IL6 SLC25A13
27 intermittent claudication 10.3 ALB IL6 VEGFA
28 critical limb ischemia 10.3 IL6 VEGFA
29 meningitis and encephalitis 10.3 ALB SOD1
30 dysferlinopathy 10.3 AQP1 AQP4 MIP
31 recurrent corneal erosion 10.3 IL1B IL6
32 hypoxia 10.3
33 bagassosis 10.3 IL1B IL6
34 meniere disease 10.3 AQP1 AQP4 MIP
35 glioma 10.3
36 diabetes insipidus, nephrogenic, autosomal 10.3 AQP1 AQP4 MIP
37 peripheral vascular disease 10.2 ALB IL6 VEGFA
38 diabetic foot ulcers 10.2 IL6 MMP9
39 chronic follicular conjunctivitis 10.2 IL1B MMP9
40 acute transverse myelitis 10.2 AQP4 IL6 MMP9
41 transverse myelitis 10.2 AQP4 IL6 MMP9
42 urinary system disease 10.2 ALB IL6 VEGFA
43 rosacea 10.2 IL6 MMP9 VEGFA
44 severe pre-eclampsia 10.2 ALB MMP9 VEGFA
45 preretinal fibrosis 10.2 GFAP VEGFA
46 poems syndrome 10.2 IL1B IL6 VEGFA
47 pleural disease 10.2 ALB IL1B KNG1
48 viral encephalitis 10.2 IL1B IL6 VEGFA
49 retinal ischemia 10.2 KNG1 SOD1 VEGFA
50 euthyroid sick syndrome 10.2 ALB IL1B IL6

Comorbidity relations with Brain Edema via Phenotypic Disease Network (PDN):


Acute Cystitis Brain Cancer
Brain Compression Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Hypertension, Essential

Graphical network of the top 20 diseases related to Brain Edema:



Diseases related to Brain Edema

Symptoms & Phenotypes for Brain Edema

Symptoms:

12
  • vomiting
  • coma
  • blurred vision
  • nausea
  • seizure

UMLS symptoms related to Brain Edema:


edema, headache, peau d'orange

MGI Mouse Phenotypes related to Brain Edema:

47 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.38 AQP1 AQP4 BDKRB2 GFAP GLUL HMOX1
2 growth/size/body region MP:0005378 10.36 AQP1 AQP4 GFAP GLUL HMOX1 IL1B
3 homeostasis/metabolism MP:0005376 10.35 ALB AQP1 AQP4 BDKRB2 GFAP GLUL
4 cellular MP:0005384 10.29 ALB BDKRB2 GFAP GLUL HMOX1 IL6
5 mortality/aging MP:0010768 10.28 ALB AQP1 AQP4 BDKRB2 GFAP GLUL
6 cardiovascular system MP:0005385 10.26 AQP1 AQP4 BDKRB2 GFAP HMOX1 IL1B
7 hematopoietic system MP:0005397 10.19 AQP1 AQP4 BDKRB2 HMOX1 IL1B IL6
8 endocrine/exocrine gland MP:0005379 10.18 ALB AQP1 AQP4 BDKRB2 HMOX1 IL6
9 immune system MP:0005387 10.16 AQP4 BDKRB2 GFAP HMOX1 IL1B IL6
10 digestive/alimentary MP:0005381 10.08 ALB AQP4 BDKRB2 GFAP IL6 MMP9
11 liver/biliary system MP:0005370 10.03 ALB GLUL HMOX1 IL6 OTC SLC25A13
12 nervous system MP:0003631 10.03 AQP1 AQP4 GFAP GLUL IL1B IL6
13 muscle MP:0005369 9.91 ALB GFAP HMOX1 IL6 MMP9 SOD1
14 renal/urinary system MP:0005367 9.85 ALB AQP1 AQP4 BDKRB2 HMOX1 IL6
15 neoplasm MP:0002006 9.8 ALB IL1B IL6 MMP9 SOD1 VEGFA
16 reproductive system MP:0005389 9.56 AQP1 BDKRB2 HMOX1 IL6 MMP9 OTC
17 vision/eye MP:0005391 9.23 AQP1 AQP4 GFAP IL6 MIP MMP9

Drugs & Therapeutics for Brain Edema

Drugs for Brain Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 310)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 85622-93-1 5394
2
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 69-65-8 453 6251
3
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
4
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2 2921-57-5
5
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2 302-25-0
6
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
7
Progesterone Approved, Vet_approved Phase 4,Phase 1,Phase 2 57-83-0 5994
8
Glyburide Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 10238-21-8 3488
9
Esmolol Approved Phase 4,Not Applicable 103598-03-4, 81147-92-4 59768
10
Nitric Oxide Approved Phase 4,Not Applicable 10102-43-9 145068
11
Nitroprusside Approved, Investigational Phase 4,Not Applicable 15078-28-1 11963622
12
Conivaptan Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 210101-16-9 151171
13
Natalizumab Approved, Investigational Phase 4 189261-10-7
14
Ornithine Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 3184-13-2, 70-26-8 6262
15
Calcium Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 7440-70-2 271
16
Prednisolone hemisuccinate Experimental Phase 4,Phase 2 2920-86-7
17 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
18 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
19 diuretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
20 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1,Early Phase 1,Not Applicable
21 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
24 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
25 Hematinics Phase 4,Phase 2,Phase 3
26 Epoetin alfa Phase 4,Phase 2,Phase 3 113427-24-0
27 Aspartic Acid Phase 4,Phase 2,Not Applicable
28 Excitatory Amino Acid Agonists Phase 4,Phase 2,Not Applicable
29 Excitatory Amino Acids Phase 4,Phase 2,Not Applicable
30 N-Methylaspartate Phase 4,Phase 2,Not Applicable
31 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
32 Tissue Plasminogen Activator Phase 4,Phase 2,Not Applicable
33 Adrenergic Agents Phase 4,Phase 3,Phase 2,Not Applicable
34 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Not Applicable
35 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
36 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
37 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Prednisolone acetate Phase 4,Phase 2
39 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
40 Methylprednisolone Acetate Phase 4,Phase 2
41 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
42 Neuroprotective Agents Phase 4,Phase 2
43 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
44 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
45 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
46 Progestins Phase 4,Phase 1,Phase 2
47 glutamine Phase 4
48 alanine Phase 4
49 phenylalanine Phase 4
50 Hypoglycemic Agents Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 181)
# Name Status NCT ID Phase Drugs
1 Supra-early Post-Surgery Chemotherapy in the Treatment on GBM Patients Unknown status NCT02520635 Phase 4 supra-early TEMODAL® chemotherapy;standard TEMODAL® chemotherapy
2 Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy Completed NCT02037815 Phase 4 20% mannitol solution, 125 ml, IV infusion in 15 min;3.1% sodium chloride solution, 125 ml, IV infusion in 15 min
3 Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion Completed NCT01809639 Phase 4 Progesterone;Placebo
4 Erythropoietin in the Prevention of Acute Mountain Sickness Completed NCT01665781 Phase 4 Erythropoietin
5 Optimized Therapy in Severe Traumatic Brain Injured Patients Completed NCT02130674 Phase 4 Dipeptiven
6 Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate Completed NCT01847651 Phase 4 LOLA or placebo
7 Effect of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation Recruiting NCT03573999 Phase 4 Mannitol;NaCl 7.5%
8 Double Blinded Randomized Control Trial of Types of IVF in Children With DKA Recruiting NCT03066440 Phase 4 Normal saline;Lactated Ringers
9 Safety and Efficacy of Glibenclamide Combined With Rt-PA in Acute Cerebral Embolism Recruiting NCT03284463 Phase 4 Glibenclamide;Placebo
10 Esmolol for the Treatment of Hypertension After Intracerebral Hemorrhage Study (ETHICHS) Not yet recruiting NCT03743103 Phase 4 Brevibloc, 10 Mg/mL Intravenous Solution;Nitroprusside, Sodium
11 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
12 Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients Terminated NCT00727090 Phase 4 Conivaptan
13 Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) Terminated NCT01211665 Phase 4 Methylprednisolone;Prednisolone
14 The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients Withdrawn NCT01526876 Phase 4 clevidipine butyrate
15 Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma Unknown status NCT01805453 Phase 3 Losartan;Placebo
16 Randomized Trial of Erythropoietin During Cerebral Malaria Unknown status NCT00697164 Phase 2, Phase 3 Placebo;Erythropoietin
17 High Dose Hyperoncotic Serum Albumin for the Treatment of the Acute Phase of Severe Head Injury Unknown status NCT00152685 Phase 2, Phase 3 human serum albumin
18 Safety and Efficacy of Therapeutic INduced HYPERTENSION in Acute Non-cardioembolic Ischemic Stroke (SETIN-HYPERTENSION) Unknown status NCT01600235 Phase 3 Phenylephrine
19 Hybrid Versus Norwood Management Strategies in Infants Undergoing Single Ventricle Palliation Unknown status NCT01134302 Phase 3
20 XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors Completed NCT00088166 Phase 3 hCRF;placebo hCRF
21 An Open-Labeled, Extended-Use of XERECEPT (hCRF) for Patients in Studies NTI 0302, 0303, or Other Designated Studies Completed NCT00226655 Phase 3 hCRF [XERECEPT (corticorelin acetate injection)]
22 Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis Completed NCT01365793 Phase 3 0.45% saline replacement fluid;0.9% saline replacement fluid;0.45% saline intravenous fluid;0.9% saline Intravenous fluid
23 Effect of Tolvaptan on Cognitive Function in Cirrhosis Completed NCT01556646 Phase 3 Tolvaptan
24 Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness Completed NCT00664001 Phase 3
25 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Completed NCT00619203 Phase 3 Glycerol and paracetamol;Paracetamol;Paracetamol;Paracetamol;Placebo;Paracetamol and glycerol;Glycerol
26 Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction Recruiting NCT02864953 Phase 3 BIIB093;Placebo
27 Treating Brain Swelling in Pediatric Cerebral Malaria Recruiting NCT03300648 Phase 3
28 Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury Recruiting NCT03339505 Phase 3
29 Imatinib in Acute Ischaemic Stroke Recruiting NCT03639922 Phase 3 Imatinib 400mg;Placebo Oral Tablet
30 Prevention of Epileptic Seizures in Acute intraCerebral Haemorrhage Not yet recruiting NCT02631759 Phase 3 Lévétiracetam;Placebo
31 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
32 Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Terminated NCT00190203 Phase 3
33 The Tilburg Vasospasm Study Terminated NCT01407614 Phase 2, Phase 3
34 Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage Terminated NCT01613235 Phase 3
35 XERECEPT® (hCRF) for Primary Glioma Patients Requiring Dexamethasone to Treat Peritumoral Brain Edema Withdrawn NCT00226668 Phase 3 hCRF;placebo hCRF
36 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
37 Feasibility Study of New MRI Protocol in Assessing Early Blood Brain Barrier Disruption (BBBD)in Related to Delay Brain Edema Unknown status NCT01830894 Phase 1, Phase 2
38 Targeted Temperature Management After Intracerebral Hemorrhage Unknown status NCT01866384 Phase 2
39 a Phase II Study in Primary Central Nervous System Lymphoma Unknown status NCT00455286 Phase 2 Methotrexate;Methylprednisolone;Temozolomide
40 NSAID RCT for Prevention of Altitude Sickness Unknown status NCT01606527 Phase 2 Ibuprofen 600mg orally three times daily
41 A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. EMCOOLS Flex.Pads (iCOOL 2) Unknown status NCT01584167 Phase 2 Cold crystalloid infusions, 0.9%NaCl or Ringer's solution
42 Safety and Feasibility Study of Targeted Temperature Management After ICH Unknown status NCT01607151 Phase 1, Phase 2
43 Continuous Endostar Infusion Combined With Radiotherapy in Patients With Brain Metastases Unknown status NCT01410370 Phase 2 Endostar
44 A Study of the Safety, Imaging and Clinical Outcomes of THR-18 in Acute Stroke Subjects Treated With tPA Unknown status NCT02572336 Phase 2 THR-18;Placebo;Tissue Plasminogen Activator (tPA)
45 Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure Unknown status NCT00470314 Phase 2 L-Ornithine L-Aspartate
46 Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke Completed NCT01428401 Phase 2 Chinese Herb Astragalus membranaceus
47 Histamine Glutamate Antagonism in Stroke Completed NCT02142712 Phase 2 Diphenhydramine;Pantoprazole;Famotidine;Dextromethorphan
48 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
49 A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients Completed NCT01282242 Phase 2 IV rt-PA
50 Glyburide Advantage in Malignant Edema and Stroke Pilot Completed NCT01268683 Phase 1, Phase 2 RP-1127 (Glyburide for injection)

Search NIH Clinical Center for Brain Edema

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cochrane evidence based reviews: brain edema

Genetic Tests for Brain Edema

Anatomical Context for Brain Edema

MalaCards organs/tissues related to Brain Edema:

42
Brain, Liver, Lung, Endothelial, Bone, Heart, Testes

Publications for Brain Edema

Articles related to Brain Edema:

(show top 50) (show all 1331)
# Title Authors Year
1
Focal Status Epilepticus-Related Unilateral Brain Edema: Magnetic Resonance Imaging Study of Children in Southwest China. ( 30611519 )
2019
2
MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral Malaria. ( 30615566 )
2019
3
Loss of body weight is accompanying cellular brain edema induced by water intoxication in the rat. ( 30628836 )
2019
4
Abrogated Caveolin-1 expression via histone modification enzyme Setdb2 regulates brain edema in a mouse model of influenza-associated encephalopathy. ( 30670717 )
2019
5
Intracellular ion and protein nanoparticle-induced osmotic pressure modify astrocyte swelling and brain edema in response to glutamate stimuli. ( 30685709 )
2019
6
Tolvaptan Attenuated Brain Edema in Experimental Intracerebral Hemorrhage. ( 30703371 )
2019
7
Tristetraprolin attenuates brain edema in a rat model of cerebral hemorrhage. ( 30729695 )
2019
8
Deficiency of plasminogen activator inhibitor type 2 limits brain edema formation after traumatic brain injury. ( 30755137 )
2019
9
Targeting Water in Brain: Role of Aquaporin-4 in Ischemic Brain Edema. ( 30791865 )
2019
10
Predictors of malignant brain edema after mechanical thrombectomy for acute ischemic stroke. ( 30798266 )
2019
11
Postmortem evaluation of brain edema: An attempt with measurements of water content and brain-weight-to-inner-skull-circumference ratio. ( 30877967 )
2019
12
Effects of pregabalin on brain edema, neurologic and histologic outcomes in experimental traumatic brain injury. ( 29730418 )
2018
13
Noninvasive measures of brain edema predict outcome in pediatric cerebral malaria. ( 29576904 )
2018
14
Case Report: A Case of Severe Cerebral Malaria Managed with Therapeutic Hypothermia and Other Modalities for Brain Edema. ( 29405103 )
2018
15
"Wounded Meningioma Syndrome": Postoperative Exacerbation of Brain Edema in Brain-Invasive Meningioma. ( 29958375 )
2018
16
Butin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage by Anti Inflammatory Pathway. ( 29755784 )
2018
17
Disruption of Intracellular ATP Generation and Tight Junction Protein Expression during the Course of Brain Edema Induced by Subacute Poisoning of 1,2-Dichloroethane. ( 29410610 )
2018
18
Polypharmacology approach against migraine with aura and brain edema for the development of an efficient inhibitor and its analogues. ( 29756582 )
2018
19
Roles of elevated 20a89HETE in the breakdown of blood brain barrier and the severity of brain edema in experimental traumatic brain injury. ( 29568904 )
2018
20
Low-dose bevacizumab as an effective pre-treatment for peri-tumoral brain edema prior to CyberKnife radiosurgery: A case report. ( 29420112 )
2018
21
Anti-high mobility group box-1 monoclonal antibody treatment of brain edema induced by influenza infection and lipopolysaccharide. ( 29573352 )
2018
22
Hypertonic Saline Alleviates Brain Edema After Traumatic Brain Injury via Downregulation of Aquaporin 4 in Rats. ( 29600800 )
2018
23
Goreisan Prevents Brain Edema after Cerebral Ischemic Stroke by Inhibiting Aquaporin 4 Upregulation in Mice. ( 29153303 )
2018
24
Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury. ( 29511497 )
2018
25
Angiopoietin-Like 4 Attenuates Brain Edema and Neurological Deficits in a Mouse Model of Experimental Intracerebral Hemorrhage. ( 29432410 )
2018
26
Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke: A Secondary Analysis of the MR CLEAN Trial. ( 29365017 )
2018
27
HMGB1 a-Box Reverses Brain Edema and Deterioration of Neurological Function in a Traumatic Brain Injury Mouse Model. ( 29742510 )
2018
28
Ischemic Brain Injury Leads to Brain Edema via Hyperthermia-Induced TRPV4 Activation. ( 29793978 )
2018
29
Exacerbated brain edema in a rat streptozotocin model of hyperglycemic ischemic stroke: Evidence for involvement of blood-brain barrier Na-K-Cl cotransport and Na/H exchange. ( 29739261 )
2018
30
Early Non-anticoagulant Desulfated Heparin After TBI: Reduced Brain Edema and Leukocyte Mobilization is Associated with Improved Watermaze Learning Ability Weeks After Injury. ( 29373460 )
2018
31
Effect of infusion speed of 7.5% hypertonic saline on brain edema in patients with craniocerebral injury: An experimental study. ( 29729380 )
2018
32
Erythropoietin Attenuates the Brain Edema Response after Experimental Traumatic Brain Injury. ( 29179621 )
2018
33
Collateral pial circulation relates to the degree of brain edema on CT 24 hours after ischemic stroke. ( 29663853 )
2018
34
Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema. ( 29434965 )
2018
35
Apatinib in refractory radiation-induced brain Edema: A case report: Erratum. ( 29505543 )
2018
36
In Reply to "Wounded Meningioma Syndrome": Postoperative Exacerbation of Brain Edema in Brain-Invasive Meningioma". ( 29958376 )
2018
37
Lack of Benefit on Brain Edema, Blood-Brain Barrier Permeability, or Cognitive Outcome in Global Inducible High Mobility Group Box 1 Knockout Mice Despite Tissue Sparing after Experimental Traumatic Brain Injury. ( 30045665 )
2018
38
20-HETE Inhibition by HET0016 Decreases the Blood-Brain Barrier Permeability and Brain Edema After Traumatic Brain Injury. ( 30061822 )
2018
39
Involvement of the p38 MAPK signaling pathway in overexpression of matrix metalloproteinase-9 during the course of brain edema in 1,2-dichloroethane-intoxicated mice. ( 30081051 )
2018
40
Successful treatment using apatinib in intractable brain edema: A case report and literatures review. ( 30081717 )
2018
41
Atorvastatin Pretreatment Attenuates Ischemic Brain Edema by Suppressing Aquaporin 4. ( 30093197 )
2018
42
Fullerenol Nanoparticles Decrease Blood-Brain Barrier Interruption and Brain Edema during Cerebral Ischemia-Reperfusion Injury Probably by Reduction of Interleukin-6 and Matrix Metalloproteinase-9 Transcription. ( 30093209 )
2018
43
Corrigendum: 20-HETE Inhibition by HET0016 Decreases the Blood-Brain Barrier Permeability and Brain Edema After Traumatic Brain Injury. ( 30154712 )
2018
44
Effect of Mannitol Irrigation on Brain Edema in a Live Rat Model. ( 30283541 )
2018
45
Changes in Posttraumatic Brain Edema in Craniectomy-Selective Brain Hypothermia Model Are Associated With Modulation of Aquaporin-4 Level. ( 30333785 )
2018
46
The Contribution of TRPV4 Channels to Astrocyte Volume Regulation and Brain Edema Formation. ( 30367945 )
2018
47
Reversible Brain Edema Associated with Flow Diverter Stent Procedures: A Retrospective Single- Center Study to Evaluate Frequency, Clinical Evolution, and Possible Mechanism. ( 30394357 )
2018
48
Aquaporins in brain edema. ( 30430614 )
2018
49
Cellular brain edema induced by water intoxication in rat experimental model. ( 30431738 )
2018
50
Involvement of CYP2E1 in the Course of Brain Edema Induced by Subacute Poisoning With 1,2-Dichloroethane in Mice. ( 30524279 )
2018

Variations for Brain Edema

Expression for Brain Edema

Search GEO for disease gene expression data for Brain Edema.

Pathways for Brain Edema

Pathways related to Brain Edema according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1 12.67 BDKRB2 HMOX1 IL6 MMP9 VEGFA
2
Show member pathways
12.15 ALB IL1B IL6 SOD1
3 11.99 AQP4 IL1B IL6 VEGFA
4 11.9 HMOX1 IL1B MMP9 VEGFA
5 11.8 IL1B IL6 MMP9
6 11.75 HMOX1 IL6 VEGFA
7 11.74 IL1B IL6 VEGFA
8
Show member pathways
11.72 IL1B IL6 MMP9 SOD1
9 11.69 IL1B IL6 VEGFA
10 11.56 IL1B IL6 MMP9
11 11.41 HMOX1 IL1B IL6 MMP9 VEGFA
12 11.36 HMOX1 IL1B IL6 MMP9
13 11.35 IL6 KNG1 MMP9
14
Show member pathways
11.26 IL1B IL6 MMP9 VEGFA
15 11.18 AQP1 AQP4 GFAP IL1B IL6 MMP9
16 11.15 HMOX1 IL1B IL6
17 11.12 IL1B IL6 SOD1
18 11.08 HMOX1 IL6 MMP9
19
Show member pathways
10.43 GLUL SLC1A2

GO Terms for Brain Edema

Cellular components related to Brain Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.97 ALB AQP1 GLUL IL1B KNG1 MMP9
2 secretory granule GO:0030141 9.58 IL1B SOD1 VEGFA
3 cell body GO:0044297 9.5 GFAP GLUL NAXE
4 platelet alpha granule lumen GO:0031093 9.33 ALB KNG1 VEGFA
5 extracellular space GO:0005615 9.28 ALB HMOX1 IL1B IL6 KNG1 MMP9
6 glial cell projection GO:0097386 9.26 GFAP GLUL
7 myelin sheath GO:0043209 9.26 ALB GFAP GLUL SOD1

Biological processes related to Brain Edema according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.93 AQP1 AQP4 MIP SLC1A2 SLC25A13
2 positive regulation of apoptotic process GO:0043065 9.88 HMOX1 IL6 KNG1 MMP9 SOD1
3 negative regulation of apoptotic process GO:0043066 9.8 ALB AQP1 IL6 MMP9 SOD1 VEGFA
4 positive regulation of angiogenesis GO:0045766 9.73 AQP1 HMOX1 IL1B VEGFA
5 response to drug GO:0042493 9.67 AQP1 OTC SLC1A2 SOD1
6 embryo implantation GO:0007566 9.63 IL1B MMP9 SOD1
7 cellular response to cadmium ion GO:0071276 9.58 HMOX1 MMP9 SOD1
8 macrophage differentiation GO:0030225 9.56 MMP9 VEGFA
9 platelet degranulation GO:0002576 9.56 ALB KNG1 SOD1 VEGFA
10 L-glutamate transmembrane transport GO:0015813 9.55 SLC1A2 SLC25A13
11 cytokine-mediated signaling pathway GO:0019221 9.55 HMOX1 IL1B IL6 MMP9 VEGFA
12 multicellular organismal water homeostasis GO:0050891 9.52 AQP1 AQP4
13 positive regulation of chemokine biosynthetic process GO:0045080 9.51 HMOX1 IL1B
14 positive regulation of neuroinflammatory response GO:0150078 9.49 IL1B IL6
15 water transport GO:0006833 9.13 AQP1 AQP4 MIP
16 positive regulation of glial cell proliferation GO:0060252 8.8 GFAP IL1B IL6

Molecular functions related to Brain Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.56 ALB AQP1 GFAP GLUL MMP9 SLC25A13
2 channel activity GO:0015267 9.33 AQP1 AQP4 MIP
3 L-glutamate transmembrane transporter activity GO:0005313 9.32 SLC1A2 SLC25A13
4 water transmembrane transporter activity GO:0005372 9.26 AQP1 AQP4
5 water channel activity GO:0015250 8.8 AQP1 AQP4 MIP

Sources for Brain Edema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
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63 PubMed
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70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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