Aliases & Classifications for Brain Edema

MalaCards integrated aliases for Brain Edema:

Name: Brain Edema 12 55 44 15 73
Intracranial Swelling 12
Cerebral Edema 73
Wet Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4724
MeSH 44 D001929
SNOMED-CT 68 2032001 85974009

Summaries for Brain Edema

MalaCards based summary : Brain Edema, also known as intracranial swelling, is related to pneumococcal meningitis and arteriovenous malformation, and has symptoms including edema, peau d'orange and headache. An important gene associated with Brain Edema is AQP4 (Aquaporin 4), and among its related pathways/superpathways are Pathways in cancer and Folate Metabolism. The drugs Mannitol and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and lung, and related phenotypes are behavior/neurological and growth/size/body region

Related Diseases for Brain Edema

Diseases related to Brain Edema via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 pneumococcal meningitis 30.6 GLUL MMP9
2 arteriovenous malformation 30.4 IL6 MMP9 VEGFA
3 intracranial hypertension 30.1 AQP1 AQP4 IL1B
4 burns 30.1 ALB IL1B
5 ischemia 29.9 HMOX1 KNG1 SOD1 VEGFA
6 cerebral hemorrhage 29.9 IL1B SOD1
7 meningitis 29.8 ALB IL1B IL6 MMP9
8 arteriovenous fistula 29.6 HMOX1 IL6
9 hepatic encephalopathy 29.0 ALB GLUL IL6 SLC1A2 SLC25A13
10 malaria 28.1 ALB HMOX1 IL1B IL6 MMP9 VEGFA
11 encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy 12.3
12 citrullinemia, type ii, adult-onset 10.9
13 encephalopathy, acute, infection-induced 4 10.9
14 severe nonproliferative diabetic retinopathy 10.8 ALB VEGFA
15 mitochondrial complex i deficiency due to acad9 deficiency 10.7
16 critical limb ischemia 10.7 IL6 VEGFA
17 angiokeratoma circumscriptum 10.7 MMP9 VEGFA
18 acroosteolysis 10.6 ALB VEGFA
19 diabetic foot ulcers 10.6 IL6 MMP9
20 obstructive jaundice 10.6 ALB IL6 SLC25A13
21 intermittent claudication 10.6 ALB IL6 VEGFA
22 inappropriate adh syndrome 10.5 AQP1 AQP4
23 recurrent corneal erosion 10.5 IL1B IL6
24 meningitis and encephalitis 10.5 ALB SOD1
25 central pontine myelinolysis 10.5 AQP1 AQP4
26 cerebritis 10.5
27 bagassosis 10.5 IL1B IL6
28 peripheral vascular disease 10.5 ALB IL6 VEGFA
29 acute hemorrhagic leukoencephalitis 10.5 AQP1 AQP4 VEGFA
30 acute transverse myelitis 10.5 AQP4 IL6 MMP9
31 brain injury 10.5
32 spinal disease 10.5 IL6 VEGFA
33 transverse myelitis 10.5 AQP4 IL6 MMP9
34 chronic follicular conjunctivitis 10.5 IL1B MMP9
35 rosacea 10.4 IL6 MMP9 VEGFA
36 dysferlinopathy 10.4 AQP1 AQP4 MIP
37 periodontitis, chronic 10.4 IL1B IL6
38 severe pre-eclampsia 10.4 ALB MMP9 VEGFA
39 meniere disease 10.4 AQP1 AQP4 MIP
40 spinal cord injury 10.4 AQP4 IL6 MMP9
41 diabetes insipidus, nephrogenic, autosomal 10.4 AQP1 AQP4 MIP
42 traumatic brain injury 10.4
43 pleural disease 10.4 ALB IL1B KNG1
44 poems syndrome 10.4 IL1B IL6 VEGFA
45 euthyroid sick syndrome 10.3 ALB IL1B IL6
46 pulpitis 10.3 IL1B IL6 KNG1
47 uremic pruritus 10.3 IL1B IL6
48 retinal ischemia 10.3 KNG1 SOD1 VEGFA
49 carpal tunnel syndrome 10.3 IL1B IL6 VEGFA
50 acute liver failure 10.3

Comorbidity relations with Brain Edema via Phenotypic Disease Network (PDN):


Acute Cystitis Brain Cancer
Brain Compression Epilepsy, Focal, with Speech Disorder and with or Without Mental Retardation
Hypertension, Essential

Graphical network of the top 20 diseases related to Brain Edema:



Diseases related to Brain Edema

Symptoms & Phenotypes for Brain Edema

UMLS symptoms related to Brain Edema:


edema, peau d'orange, headache

MGI Mouse Phenotypes related to Brain Edema:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.29 AQP1 GLUL AQP4 BDKRB2 IL6 SLC1A2
2 growth/size/body region MP:0005378 10.29 AQP1 GLUL AQP4 ANXA1 IL6 SLC1A2
3 homeostasis/metabolism MP:0005376 10.28 AQP1 GLUL ALB AQP4 ANXA1 BDKRB2
4 cardiovascular system MP:0005385 10.24 BDKRB2 AQP1 AQP4 ANXA1 IL6 HMOX1
5 cellular MP:0005384 10.22 ANXA1 BDKRB2 ALB MMP9 SLC1A2 GLUL
6 mortality/aging MP:0010768 10.21 AQP1 GLUL ALB AQP4 ANXA1 BDKRB2
7 hematopoietic system MP:0005397 10.16 BDKRB2 AQP1 AQP4 ANXA1 MMP9 IL1B
8 endocrine/exocrine gland MP:0005379 10.15 BDKRB2 AQP1 ALB AQP4 ANXA1 IL6
9 digestive/alimentary MP:0005381 10.05 ANXA1 BDKRB2 ALB AQP4 MMP9 IL6
10 nervous system MP:0003631 10 AQP1 GLUL AQP4 ANXA1 SLC1A2 IL6
11 liver/biliary system MP:0005370 9.95 ALB GLUL IL6 HMOX1 VEGFA SLC25A13
12 neoplasm MP:0002006 9.87 ALB ANXA1 IL1B IL6 MMP9 VEGFA
13 renal/urinary system MP:0005367 9.81 AQP1 ALB AQP4 BDKRB2 IL6 HMOX1
14 skeleton MP:0005390 9.56 ANXA1 BDKRB2 AQP1 IL1B MMP9 IL6
15 vision/eye MP:0005391 9.17 AQP1 AQP4 MMP9 IL6 MIP SOD1

Drugs & Therapeutics for Brain Edema

Drugs for Brain Edema (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 295)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 69-65-8 453 6251
2
Temozolomide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 85622-93-1 5394
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
5
Acetazolamide Approved, Vet_approved Phase 4,Phase 2,Not Applicable 59-66-5 1986
6
Progesterone Approved, Vet_approved Phase 4,Phase 1,Phase 2 57-83-0 5994
7
Conivaptan Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 210101-16-9 151171
8
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
9
Glyburide Approved Phase 4,Phase 3,Phase 1,Phase 2 10238-21-8 3488
10
Dacarbazine Approved, Investigational Phase 4,Early Phase 1 4342-03-4 5351166
11
Natalizumab Approved, Investigational Phase 4 189261-10-7
12
Ornithine Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 70-26-8, 3184-13-2 6262
13 Prednisolone acetate Phase 4,Phase 2
14 Epoetin alfa Phase 4,Phase 2,Phase 3 113427-24-0
15 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
16 diuretics Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
17 glucocorticoids Phase 4,Phase 3,Phase 2,Phase 1
18 Methylprednisolone acetate Phase 4,Phase 2
19 Methylprednisolone Hemisuccinate Phase 4,Phase 2
20 Gastrointestinal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
21 Natriuretic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
22 Neuroprotective Agents Phase 4,Phase 3,Phase 2
23 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
24 Hematinics Phase 4,Phase 2,Phase 3
25 Tissue Plasminogen Activator Phase 4,Phase 2,Not Applicable
26 N-Methylaspartate Phase 4,Phase 2,Not Applicable
27 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
28 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
29 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
30 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
31 Pharmaceutical Solutions Phase 4,Phase 2,Phase 1,Early Phase 1,Not Applicable
32 Excitatory Amino Acid Agonists Phase 4,Phase 2,Not Applicable
33 Excitatory Amino Acids Phase 4,Phase 2,Not Applicable
34 Prednisolone hemisuccinate Phase 4,Phase 2
35 Prednisolone phosphate Phase 4,Phase 2
36 Antiemetics Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
37 Protective Agents Phase 4,Phase 3,Phase 2,Not Applicable
38 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2,Phase 1
39 Autonomic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
40 Antineoplastic Agents, Alkylating Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
41 Antineoplastic Agents, Hormonal Phase 4,Phase 3,Phase 2,Phase 1
42 Progestins Phase 4,Phase 1,Phase 2
43
Histamine Phosphate Phase 4,Phase 2 51-74-1 65513
44 calcium channel blockers Phase 4,Phase 2,Phase 3,Not Applicable
45 Neuromuscular Blocking Agents Phase 4,Phase 2
46 Histamine Antagonists Phase 4,Phase 2
47 Vasopressins Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
48 Hypoglycemic Agents Phase 4,Phase 3,Phase 1,Phase 2
49 Anticonvulsants Phase 4,Phase 3,Phase 2,Not Applicable
50 Arginine Vasopressin Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 169)
# Name Status NCT ID Phase Drugs
1 Correlation of Measured and Calculated Serum Osmolality During Hyperosmolar Drugs Infusion in Patients After Craniotomy Completed NCT02037815 Phase 4 20% mannitol solution, 125 ml, IV infusion in 15 min;3.1% sodium chloride solution, 125 ml, IV infusion in 15 min
2 Acetazolamide for the Prevention of High Altitude Illness: a Comparison of Dosing Completed NCT01993667 Phase 4 Acetazolamide
3 Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion Completed NCT01809639 Phase 4 Progesterone;Placebo
4 Erythropoietin in the Prevention of Acute Mountain Sickness Completed NCT01665781 Phase 4 Erythropoietin
5 Optimized Therapy in Severe Traumatic Brain Injured Patients Completed NCT02130674 Phase 4 Dipeptiven
6 Brain Muscle Axis During Treatment of Hepatic Encephalopathy With L-ornithine L-aspartate Completed NCT01847651 Phase 4 LOLA or placebo
7 Supra-early Post-Surgery Chemotherapy in the Treatment on GBM Patients Recruiting NCT02520635 Phase 4 supra-early TEMODAL® chemotherapy;standard TEMODAL® chemotherapy
8 Safety and Efficacy of Glibenclamide Combined With Rt-PA in Acute Cerebral Embolism Recruiting NCT03284463 Phase 4 Glibenclamide;Placebo
9 Effect of Mannitol 20% Versus Hypertonic Saline 7.5% in Brain Metabolism and Oxygenation Not yet recruiting NCT03573999 Phase 4 Mannitol;NaCl 7.5%
10 Double Blinded Randomized Control Trial of Types of IVF in Children With DKA Not yet recruiting NCT03066440 Phase 4 Normal saline;Lactated Ringers
11 IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis Terminated NCT00774631 Phase 4
12 Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients Terminated NCT00727090 Phase 4 Conivaptan
13 Corticosteroids for Immune Reconstitution Inflammatory Syndrome (IRIS) Terminated NCT01211665 Phase 4 Methylprednisolone;Prednisolone
14 The Effect of Clevidipine on Intracranial Pressure and Cerebral Perfusion Pressure (CCP) in Brain Injured Patients Withdrawn NCT01526876 Phase 4 clevidipine butyrate
15 Randomized Trial of Erythropoietin During Cerebral Malaria Unknown status NCT00697164 Phase 2, Phase 3 Placebo;Erythropoietin
16 High Dose Hyperoncotic Serum Albumin for the Treatment of the Acute Phase of Severe Head Injury Unknown status NCT00152685 Phase 2, Phase 3 human serum albumin
17 Hybrid Versus Norwood Management Strategies in Infants Undergoing Single Ventricle Palliation Unknown status NCT01134302 Phase 3
18 XERECEPT® (hCRF) for Patients Requiring Dexamethasone to Treat Edema Associated With Brain Tumors Completed NCT00088166 Phase 3 hCRF;placebo hCRF
19 An Open-Labeled, Extended-Use of XERECEPT (hCRF) for Patients in Studies NTI 0302, 0303, or Other Designated Studies Completed NCT00226655 Phase 3 hCRF [XERECEPT (corticorelin acetate injection)]
20 Randomized Control Trial of Fluid Therapy for Pediatric Diabetic Ketoacidosis Completed NCT01365793 Phase 3 0.45% saline replacement fluid;0.9% saline replacement fluid;0.45% saline intravenous fluid;0.9% saline Intravenous fluid
21 Effect of Tolvaptan on Cognitive Function in Cirrhosis Completed NCT01556646 Phase 3 Tolvaptan
22 Anti-Oxidant Supplementation for the Prevention of Acute Mountain Sickness Completed NCT00664001 Phase 3
23 Oral Glycerol and High-Dose Rectal Paracetamol to Improve the Prognosis of Childhood Bacterial Meningitis Completed NCT00619203 Phase 3 Glycerol and paracetamol;Paracetamol;Paracetamol;Paracetamol;Placebo;Paracetamol and glycerol;Glycerol
24 Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury Recruiting NCT03339505 Phase 3
25 Safety and Efficacy of Therapeutic INduced HYPERTENSION in Acute Non-cardioembolic Ischemic Stroke (SETIN-HYPERTENSION) Recruiting NCT01600235 Phase 3 Phenylephrine
26 Angiotensin II Receptor Blockers, Steroids and Radiotherapy in Glioblastoma Active, not recruiting NCT01805453 Phase 3 Losartan;Placebo
27 Phase 3 Study to Evaluate the Efficacy and Safety of Intravenous BIIB093 (Glibenclamide) for Severe Cerebral Edema Following Large Hemispheric Infarction Not yet recruiting NCT02864953 Phase 3 BIIB093;Placebo
28 Treating Brain Swelling in Pediatric Cerebral Malaria Not yet recruiting NCT03300648 Phase 3
29 Prevention of Epileptic Seizures in Acute intraCerebral Haemorrhage Not yet recruiting NCT02631759 Phase 3 Lévétiracetam;Placebo
30 Hypertonic Saline vs. Mannitol for Elevated Intercranial Pressure Terminated NCT01111682 Phase 3 Mannitol;Hypertonic Saline
31 Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Terminated NCT00190203 Phase 3
32 The Tilburg Vasospasm Study Terminated NCT01407614 Phase 2, Phase 3
33 Induced Hypertension for Treatment of Delayed Cerebral Ischaemia After Aneurysmal Subarachnoid Haemorrhage Terminated NCT01613235 Phase 3
34 XERECEPT® (hCRF) for Primary Glioma Patients Requiring Dexamethasone to Treat Peritumoral Brain Edema Withdrawn NCT00226668 Phase 3 hCRF;placebo hCRF
35 Labetalol Versus Magnesium Sulfate (MgSO4) for the Prevention of Eclampsia Trial Withdrawn NCT00293735 Phase 2, Phase 3 labetalol (seizure prevention);MgSO4 (seizure prevention)
36 Feasibility Study of New MRI Protocol in Assessing Early Blood Brain Barrier Disruption (BBBD)in Related to Delay Brain Edema Unknown status NCT01830894 Phase 1, Phase 2
37 Targeted Temperature Management After Intracerebral Hemorrhage Unknown status NCT01866384 Phase 2
38 a Phase II Study in Primary Central Nervous System Lymphoma Unknown status NCT00455286 Phase 2 Methotrexate;Methylprednisolone;Temozolomide
39 NSAID RCT for Prevention of Altitude Sickness Unknown status NCT01606527 Phase 2 Ibuprofen 600mg orally three times daily
40 A Randomized Trial Comparing 2 Methods for Rapid Induction of Cooling in Stroke Patients, Cold Infusions vs. EMCOOLS Flex.Pads (iCOOL 2) Unknown status NCT01584167 Phase 2 Cold crystalloid infusions, 0.9%NaCl or Ringer's solution
41 Safety and Feasibility Study of Targeted Temperature Management After ICH Unknown status NCT01607151 Phase 1, Phase 2
42 Continuous Endostar Infusion Combined With Radiotherapy in Patients With Brain Metastases Unknown status NCT01410370 Phase 2 Endostar
43 A Study of the Safety, Imaging and Clinical Outcomes of THR-18 in Acute Stroke Subjects Treated With tPA Unknown status NCT02572336 Phase 2 THR-18;Placebo;Tissue Plasminogen Activator (tPA)
44 Therapeutic Efficacy of L-Ornithine L-Aspartate Infusion in Patients With Acute Liver Failure Unknown status NCT00470314 Phase 2 L-Ornithine L-Aspartate
45 Astragalus Membranaceus for Brain Edema Induced by Hemorrhagic Stroke Completed NCT01428401 Phase 2 Chinese Herb Astragalus membranaceus
46 Histamine Glutamate Antagonism in Stroke Completed NCT02142712 Phase 2 Diphenhydramine;Pantoprazole;Famotidine;Dextromethorphan
47 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
48 A Study of Intravenous Thrombolysis With Alteplase in MRI-Selected Patients Completed NCT01282242 Phase 2 IV rt-PA
49 Glyburide Advantage in Malignant Edema and Stroke Pilot Completed NCT01268683 Phase 1, Phase 2 RP-1127 (Glyburide for injection)
50 A Pilot Study: Safety & TOlerability of Hypertonic Saline Administration Via IntraOsseous Access Completed NCT03276494 Phase 2 injection of intraosseous hypertonic saline

Search NIH Clinical Center for Brain Edema

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: brain edema

Genetic Tests for Brain Edema

Anatomical Context for Brain Edema

MalaCards organs/tissues related to Brain Edema:

41
Brain, Liver, Lung, Endothelial, Bone, Heart, Testes

Publications for Brain Edema

Articles related to Brain Edema:

(show top 50) (show all 682)
# Title Authors Year
1
Effects of pregabalin on brain edema, neurologic and histologic outcomes in experimental traumatic brain injury. ( 29730418 )
2018
2
Noninvasive measures of brain edema predict outcome in pediatric cerebral malaria. ( 29576904 )
2018
3
Case Report: A Case of Severe Cerebral Malaria Managed with Therapeutic Hypothermia and Other Modalities for Brain Edema. ( 29405103 )
2018
4
"Wounded Meningioma Syndrome": Postoperative Exacerbation of Brain Edema in Brain-Invasive Meningioma. ( 29958375 )
2018
5
Butin Attenuates Brain Edema in a Rat Model of Intracerebral Hemorrhage by Anti Inflammatory Pathway. ( 29755784 )
2018
6
Disruption of Intracellular ATP Generation and Tight Junction Protein Expression during the Course of Brain Edema Induced by Subacute Poisoning of 1,2-Dichloroethane. ( 29410610 )
2018
7
Polypharmacology approach against migraine with aura and brain edema for the development of an efficient inhibitor and its analogues. ( 29756582 )
2018
8
Roles of elevated 20a89HETE in the breakdown of blood brain barrier and the severity of brain edema in experimental traumatic brain injury. ( 29568904 )
2018
9
Low-dose bevacizumab as an effective pre-treatment for peri-tumoral brain edema prior to CyberKnife radiosurgery: A case report. ( 29420112 )
2018
10
Anti-high mobility group box-1 monoclonal antibody treatment of brain edema induced by influenza infection and lipopolysaccharide. ( 29573352 )
2018
11
Hypertonic Saline Alleviates Brain Edema After Traumatic Brain Injury via Downregulation of Aquaporin 4 in Rats. ( 29600800 )
2018
12
Goreisan Prevents Brain Edema after Cerebral Ischemic Stroke by Inhibiting Aquaporin 4 Upregulation in Mice. ( 29153303 )
2018
13
Role of melatonin receptors in the effect of estrogen on brain edema, intracranial pressure and expression of aquaporin 4 after traumatic brain injury. ( 29511497 )
2018
14
Angiopoietin-Like 4 Attenuates Brain Edema and Neurological Deficits in a Mouse Model of Experimental Intracerebral Hemorrhage. ( 29432410 )
2018
15
Association of Reperfusion With Brain Edema in Patients With Acute Ischemic Stroke: A Secondary Analysis of the MR CLEAN Trial. ( 29365017 )
2018
16
HMGB1 a-Box Reverses Brain Edema and Deterioration of Neurological Function in a Traumatic Brain Injury Mouse Model. ( 29742510 )
2018
17
Ischemic Brain Injury Leads to Brain Edema via Hyperthermia-Induced TRPV4 Activation. ( 29793978 )
2018
18
Exacerbated brain edema in a rat streptozotocin model of hyperglycemic ischemic stroke: Evidence for involvement of blood-brain barrier Na-K-Cl cotransport and Na/H exchange. ( 29739261 )
2018
19
Early Non-anticoagulant Desulfated Heparin After TBI: Reduced Brain Edema and Leukocyte Mobilization is Associated with Improved Watermaze Learning Ability Weeks After Injury. ( 29373460 )
2018
20
Effect of infusion speed of 7.5% hypertonic saline on brain edema in patients with craniocerebral injury: An experimental study. ( 29729380 )
2018
21
Erythropoietin Attenuates the Brain Edema Response after Experimental Traumatic Brain Injury. ( 29179621 )
2018
22
Collateral pial circulation relates to the degree of brain edema on CT 24 hours after ischemic stroke. ( 29663853 )
2018
23
Expression of CXC-motif-chemokine 12 and the receptor C-X-C receptor 4 in glioma and theeffect on peritumoral brain edema. ( 29434965 )
2018
24
Apatinib in refractory radiation-induced brain Edema: A case report: Erratum. ( 29505543 )
2018
25
In Reply to "Wounded Meningioma Syndrome": Postoperative Exacerbation of Brain Edema in Brain-Invasive Meningioma". ( 29958376 )
2018
26
Increased cerebral expressions of MMPs, CLDN5, OCLN, ZO1 and AQPs are associated with brain edema following fatal heat stroke. ( 28490769 )
2017
27
Apatinib in refractory radiation-induced brain edema: A case report. ( 29145238 )
2017
28
The Subarachnoid Hemorrhage Early Brain Edema Score Predicts Delayed Cerebral Ischemia and Clinical Outcomes. ( 28973675 )
2017
29
Brain edema with clasmatodendrosis complicating ataxia telangiectasia. ( 28351596 )
2017
30
Delayed Brain Edema and Swelling following Craniectomy for Evacuation of an Epidural Abscess that Improved by Cranioplasty: Case Report. ( 28852606 )
2017
31
Three-dimensional organ scanning reveals brain edema reduction in a rat model of stroke treated with an aquaporin 4 inhibitor. ( 28523299 )
2017
32
An experimental model of the "dual diagnosis": Effect of cytotoxic brain edema plus peripheral neuropathy on the spontaneous locomotor activity of rats. ( 29298281 )
2017
33
Simulating vasogenic brain edema using chronic VEGF infusion. ( 28059647 )
2017
34
Unenhanced Dual-Energy Computed Tomography: Visualization of Brain Edema. ( 28915161 )
2017
35
Efficacy and safety of bevacizumab treatment for refractory brain edema: Case report. ( 29095257 )
2017
36
Permeability surface area product analysis in malignant brain edema prediction - A pilot study. ( 28431614 )
2017
37
Evaluation of Brain Edema Formation Defined By MRI After LINAC-based Stereotactic Radiosurgery. ( 28740448 )
2017
38
Raised intracranial pressure and brain edema. ( 28987174 )
2017
39
Asymptomatic Brain Edema after Hemodialysis Initiation in a Patient with Severe Uremia. ( 28553356 )
2017
40
Magnesium Sulfate attenuates brain edema by lowering AQP4 expression and inhibits glia-mediated neuroinflammation in a rodent model of eclampsia. ( 29288747 )
2017
41
Reperfusion after ischemic stroke is associated with reduced brain edema. ( 28731381 )
2017
42
Reduction of Ischemic Brain Edema by Combined use of Paeoniflorin and Astragaloside IV via Down-Regulating Connexin 43. ( 28752625 )
2017
43
Corrigendum to "The optimization of fluorescence imaging of brain tumor tissue differentiated from brain edema-in vivo kinetic study of 5-aminolevulinic acid and talaporfin sodium" [Photodiagn. Photodyn. Ther. 6 (2009), 19-27]. ( 28619661 )
2017
44
Report - Cerebral electrical impedance value reflects brain edema caused by cardiopulmonary bypass in infants. ( 28653939 )
2017
45
Quantitative MRI study of the permeability of peritumoral brain edema in lung cancer patients with brain metastases. ( 28633995 )
2017
46
Mathematical model in post-mortem estimation of brain edema using morphometric parameters. ( 27914998 )
2017
47
Prediction of Histological Grade and Completeness of Resection of Intracranial Meningiomas: Role of Peritumoural Brain Edema. ( 28814931 )
2017
48
Neuroprotective Effects of Exercise on Brain Edema and Neurological Movement Disorders Following the Cerebral Ischemia and Reperfusion in Rats. ( 28446953 )
2017
49
Chiari Type 1 Malformation-induced Intracranial Hypertension with Diffuse Brain Edema Treated with Foramen Magnum Decompression: A Case Report. ( 29018653 )
2017
50
Therapeutic time window for conivaptan treatment against stroke-evoked brain edema and blood-brain barrier disruption in mice. ( 28854286 )
2017

Variations for Brain Edema

Expression for Brain Edema

Search GEO for disease gene expression data for Brain Edema.

Pathways for Brain Edema

Pathways related to Brain Edema according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1 12.64 BDKRB2 HMOX1 IL6 MMP9 VEGFA
2
Show member pathways
12.13 ALB IL1B IL6 SOD1
3 11.97 AQP4 IL1B IL6 VEGFA
4 11.88 HMOX1 IL1B MMP9 VEGFA
5 11.78 IL1B IL6 MMP9
6 11.73 HMOX1 IL6 VEGFA
7 11.72 IL1B IL6 VEGFA
8 11.67 IL1B IL6 VEGFA
9 11.51 ANXA1 AQP1 AQP4 IL1B IL6 MMP9
10 11.36 HMOX1 IL1B IL6 MMP9
11 11.33 IL6 KNG1 MMP9
12
Show member pathways
11.26 IL1B IL6 MMP9 VEGFA
13 11.16 ANXA1 HMOX1 IL1B IL6 MMP9 VEGFA
14 11.12 HMOX1 IL1B IL6
15 11.09 IL1B IL6 SOD1
16 11.03 HMOX1 IL6 MMP9
17 10.85 HMOX1 IL6
18
Show member pathways
10.41 GLUL SLC1A2

GO Terms for Brain Edema

Cellular components related to Brain Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.91 ALB ANXA1 AQP1 GLUL IL1B KNG1
2 extracellular region GO:0005576 9.61 ALB ANXA1 IL1B IL6 KNG1 MMP9
3 secretory granule GO:0030141 9.5 IL1B SOD1 VEGFA
4 platelet alpha granule lumen GO:0031093 9.33 ALB KNG1 VEGFA
5 extracellular space GO:0005615 9.32 ALB ANXA1 HMOX1 IL1B IL6 KNG1

Biological processes related to Brain Edema according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 transmembrane transport GO:0055085 9.95 AQP1 AQP4 MIP SLC1A2 SLC25A13
2 inflammatory response GO:0006954 9.88 ANXA1 BDKRB2 IL1B IL6 KNG1
3 response to drug GO:0042493 9.86 ANXA1 AQP1 SLC1A2 SOD1
4 cellular response to hypoxia GO:0071456 9.75 AQP1 HMOX1 VEGFA
5 positive regulation of angiogenesis GO:0045766 9.73 AQP1 HMOX1 IL1B VEGFA
6 positive regulation of T cell proliferation GO:0042102 9.69 ANXA1 IL1B IL6
7 cellular response to hydrogen peroxide GO:0070301 9.67 ANXA1 AQP1 IL6
8 embryo implantation GO:0007566 9.63 IL1B MMP9 SOD1
9 positive regulation of apoptotic process GO:0043065 9.63 ANXA1 HMOX1 IL6 KNG1 MMP9 SOD1
10 platelet degranulation GO:0002576 9.62 ALB KNG1 SOD1 VEGFA
11 positive regulation of vascular endothelial growth factor receptor signaling pathway GO:0030949 9.59 IL1B VEGFA
12 macrophage differentiation GO:0030225 9.58 MMP9 VEGFA
13 cellular response to cadmium ion GO:0071276 9.58 HMOX1 MMP9 SOD1
14 L-glutamate transmembrane transport GO:0015813 9.57 SLC1A2 SLC25A13
15 multicellular organismal water homeostasis GO:0050891 9.54 AQP1 AQP4
16 positive regulation of cell migration involved in sprouting angiogenesis GO:0090050 9.54 ANXA1 HMOX1 VEGFA
17 positive regulation of chemokine biosynthetic process GO:0045080 9.52 HMOX1 IL1B
18 negative regulation of apoptotic process GO:0043066 9.5 ALB ANXA1 AQP1 IL6 MMP9 SOD1
19 water transport GO:0006833 9.43 AQP1 AQP4 MIP
20 cytokine-mediated signaling pathway GO:0019221 9.1 ANXA1 HMOX1 IL1B IL6 MMP9 VEGFA

Molecular functions related to Brain Edema according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.8 ALB AQP1 GLUL MMP9 SOD1 VEGFA
2 L-glutamate transmembrane transporter activity GO:0005313 9.26 SLC1A2 SLC25A13
3 water transmembrane transporter activity GO:0005372 9.16 AQP1 AQP4
4 channel activity GO:0015267 9.13 AQP1 AQP4 MIP
5 water channel activity GO:0015250 8.8 AQP1 AQP4 MIP

Sources for Brain Edema

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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