MCID: BRN030
MIFTS: 35

Brain Ependymoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Ependymoma

MalaCards integrated aliases for Brain Ependymoma:

Name: Brain Ependymoma 12 15
Ependymal Tumor of Brain 12
Ependymoma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7497
NCIt 50 C3861
UMLS 73 C0238029

Summaries for Brain Ependymoma

Disease Ontology : 12 A brain glioma that is characterized by tumor of the ependyma, has material basis in abnormally proliferating cells derives from ependymal cells, located in spine in adults and located in intracranial (4th ventricle) in children.

MalaCards based summary : Brain Ependymoma, also known as ependymal tumor of brain, is related to ependymoma and adult brain ependymoma. An important gene associated with Brain Ependymoma is MKI67 (Marker Of Proliferation Ki-67), and among its related pathways/superpathways are Proteoglycans in cancer and Colorectal Cancer Metastasis. Affiliated tissues include brain, lung and colon, and related phenotype is no phenotypic analysis.

Related Diseases for Brain Ependymoma

Diseases in the Brain Ependymoma family:

Adult Brain Ependymoma

Diseases related to Brain Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 ependymoma 30.0 EGFR MKI67
2 adult brain ependymoma 12.4
3 malignant ependymoma 11.2
4 spitz nevus 10.1 MKI67 TP53
5 oral leukoplakia 10.1 MKI67 TP53
6 adenosarcoma 10.1 MKI67 TP53
7 necrotizing sialometaplasia 10.0 MKI67 TP53
8 embryonal sarcoma 10.0 MKI67 TP53
9 keratocystic odontogenic tumor 10.0 MKI67 TP53
10 inverted papilloma 10.0 MKI67 TP53
11 keratoacanthoma 10.0 MKI67 TP53
12 cervical squamous cell carcinoma 10.0 MKI67 TP53
13 meningioma, familial 10.0 MKI67 TP53
14 breast squamous cell carcinoma 10.0 EGFR TP53
15 microglandular adenosis 10.0 EGFR TP53
16 pleomorphic carcinoma 10.0 EGFR TP53
17 pulmonary blastoma 10.0 EGFR TP53
18 gliomatosis cerebri 10.0 EGFR TP53
19 esophageal basaloid squamous cell carcinoma 10.0 EGFR TP53
20 basaloid squamous cell carcinoma 10.0 EGFR TP53
21 primary peritoneal carcinoma 10.0 EGFR TP53
22 pre-malignant neoplasm 10.0 EGFR TP53
23 vulva cancer 10.0 EGFR TP53
24 brain glioma 10.0 EGFR TP53
25 laryngeal disease 10.0 EGFR TP53
26 oropharynx cancer 10.0 EGFR TP53
27 pharynx cancer 10.0 EGFR TP53
28 penile cancer 10.0 EGFR TP53
29 in situ carcinoma 10.0 EGFR TP53
30 giant cell glioblastoma 10.0 EGFR TP53
31 lung benign neoplasm 10.0 EGFR TP53
32 breast carcinoma in situ 10.0 EGFR TP53
33 brain stem glioma 10.0 EGFR TP53
34 esophageal disease 10.0 EGFR TP53
35 adenosquamous carcinoma 10.0 EGFR TP53
36 supratentorial cancer 10.0 EGFR TP53
37 cerebrum cancer 10.0 EGFR TP53
38 estrogen-receptor positive breast cancer 10.0 EGFR TP53
39 small cell carcinoma 10.0 EGFR TP53
40 grade iii astrocytoma 10.0 EGFR TP53
41 central nervous system cancer 10.0 EGFR TP53
42 nervous system cancer 10.0 EGFR TP53
43 colonic disease 10.0 EGFR TP53
44 colorectal adenocarcinoma 10.0 EGFR TP53
45 laryngeal squamous cell carcinoma 9.9 EGFR TP53
46 oral cancer 9.9 EGFR TP53
47 stomach disease 9.9 EGFR TP53
48 female reproductive system disease 9.9 EGFR TP53
49 reproductive system disease 9.9 EGFR TP53
50 respiratory system cancer 9.9 EGFR TP53

Graphical network of the top 20 diseases related to Brain Ependymoma:



Diseases related to Brain Ependymoma

Symptoms & Phenotypes for Brain Ependymoma

MGI Mouse Phenotypes related to Brain Ependymoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 8.8 EGFR MKI67 TP53

Drugs & Therapeutics for Brain Ependymoma

Search Clinical Trials , NIH Clinical Center for Brain Ependymoma

Genetic Tests for Brain Ependymoma

Anatomical Context for Brain Ependymoma

MalaCards organs/tissues related to Brain Ependymoma:

41
Brain, Lung, Colon, Prostate, Pancreas, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Brain Ependymoma:

19
Spine In Adults, Intracranial (4th Ventricle) In Children

Publications for Brain Ependymoma

Articles related to Brain Ependymoma:

# Title Authors Year
1
A brain ependymoma with psychiatric manifestation. ( 29332363 )
2017
2
[Expression of epidermal growth factor receptor and Ki-67 antigen in brain ependymoma and the correlation between them]. ( 19257969 )
2008
3
Brain ependymoma case report. ( 13346237 )
1956

Variations for Brain Ependymoma

Expression for Brain Ependymoma

Search GEO for disease gene expression data for Brain Ependymoma.

Pathways for Brain Ependymoma

GO Terms for Brain Ependymoma

Biological processes related to Brain Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to drug GO:0035690 9.16 EGFR TP53
2 cell proliferation GO:0008283 9.13 EGFR MKI67 TP53
3 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.62 EGFR TP53

Molecular functions related to Brain Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.13 EGFR MKI67 TP53
2 protein phosphatase binding GO:0019903 8.62 EGFR TP53

Sources for Brain Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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