MCID: BRN031
MIFTS: 36

Brain Germinoma

Categories: Cancer diseases, Neuronal diseases
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Aliases & Classifications for Brain Germinoma

MalaCards integrated aliases for Brain Germinoma:

Name: Brain Germinoma 11 14 71
Intracranial Germinoma 11 71
Germinoma of the Brain 11

Classifications:



External Ids:

Disease Ontology 11 DOID:2127
NCIt 49 C6284
UMLS 71 C1332606 C1334240

Summaries for Brain Germinoma

Disease Ontology: 11 A brain cancer that is characterized by abnormally proliferating cells, derives from germ cells.

MalaCards based summary: Brain Germinoma, also known as intracranial germinoma, is related to central nervous system germinoma and teratoma. An important gene associated with Brain Germinoma is PAGR1 (PAXIP1 Associated Glutamate Rich Protein 1), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. The drugs Carboplatin and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include brain, medulla oblongata and pineal, and related phenotypes are Decreased OCT4 protein expression and Decreased NANOG protein expression

Related Diseases for Brain Germinoma

Diseases related to Brain Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 central nervous system germinoma 32.2 MIR371A ESRG
2 teratoma 30.1 POU5F1 MIR371A KIT AFP
3 seminoma 30.1 TFAP2C POU5F1 NANOG KIT AFP
4 embryonal carcinoma 30.0 POU5F1 NANOG KIT ESRG AFP
5 testicular germ cell tumor 29.9 MIR373 MIR371A KITLG KIT
6 mixed germ cell cancer 29.9 POU5F1 NANOG KIT AFP
7 endodermal sinus tumor 29.4 POU5F1 MIR373 MIR371A KIT AFP
8 germinoma 29.4 POU5F1 MIR371A KIT ESRG AFP
9 dysgerminoma 29.4 MIR371A KITLG KIT AFP
10 malignant teratoma 29.0 PRDM14 POU5F1 NANOG MIR371A KIT AFP
11 nervous system disease 28.7 POU5F1 NANOG MIR373 MIR371A KIT AFP
12 dysgerminoma of ovary 28.6 POU5F1 NANOG MIR371A KITLG KIT AFP
13 childhood brain germinoma 11.5
14 central diabetes insipidus 10.5
15 diabetes insipidus 10.5
16 germ cell tumor 10.5
17 hydrocephalus 10.4
18 pituitary hormone deficiency, combined, 2 10.4
19 hypopituitarism 10.3
20 brain cancer 10.3
21 obstructive hydrocephalus 10.3
22 mediastinum seminoma 10.3 KIT AFP
23 testicular gonadoblastoma 10.3 KIT AFP
24 malignant gastric teratoma 10.3 KIT AFP
25 gastric teratoma 10.3 KIT AFP
26 pineal region teratoma 10.3 KIT AFP
27 pineal region germinoma 10.3 PRDM14 AFP
28 diabetes insipidus, neurohypophyseal 10.3
29 down syndrome 10.3
30 childhood testicular germ cell tumor 10.3 POU5F1 AFP
31 adult type testicular granulosa cell tumor 10.3 KIT AFP
32 ovarian mixed germ cell neoplasm 10.2 KIT AFP
33 malignant pineal area germ cell neoplasm 10.2 PRDM14 AFP
34 hepatic angiomyolipoma 10.2 KIT AFP
35 liver leiomyoma 10.2 KIT AFP
36 ovarian embryonal carcinoma 10.2 POU5F1 AFP
37 liver sarcoma 10.2 KIT AFP
38 ovarian endodermal sinus tumor 10.2 POU5F1 AFP
39 endometrial small cell carcinoma 10.2 KIT AFP
40 core binding factor acute myeloid leukemia 10.2 PAGR1 KIT
41 ovarian primitive germ cell tumor 10.2 POU5F1 AFP
42 central nervous system germ cell tumor 10.2 PAGR1 AFP
43 mediastinal cancer 10.2 KIT AFP
44 liver leiomyosarcoma 10.2 KIT AFP
45 klatskin's tumor 10.2 MIR373 AFP
46 chromosome 16p11.2 deletion syndrome 10.2 PAGR1 CDIPTOSP
47 spastic paraplegia, ataxia, and mental retardation 10.1
48 growth hormone deficiency 10.1
49 deafness, autosomal dominant 69 10.1 KITLG KIT
50 intratubular embryonal carcinoma 10.1 POU5F1 KIT AFP

Graphical network of the top 20 diseases related to Brain Germinoma:



Diseases related to Brain Germinoma

Symptoms & Phenotypes for Brain Germinoma

GenomeRNAi Phenotypes related to Brain Germinoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased OCT4 protein expression GR00184-A-2 10.09 NANOG POU5F1 PRDM14
2 Decreased OCT4 protein expression GR00184-A-5 10.09 NANOG POU5F1 PRDM14
3 Decreased OCT4 protein expression GR00184-A-7 10.09 NANOG POU5F1 PRDM14
4 Decreased NANOG protein expression GR00184-A-3 9.75 NANOG POU5F1 PRDM14
5 Decreased NANOG protein expression GR00184-A-6 9.75 NANOG POU5F1 PRDM14
6 Decreased NANOG protein expression GR00184-A-8 9.75 NANOG POU5F1 PRDM14
7 Decreased POU5F1-GFP protein expression GR00184-A-1 9.55 POU5F1 PRDM14
8 Decreased POU5F1-GFP protein expression GR00184-A-4 9.55 NANOG POU5F1 PRDM14

Drugs & Therapeutics for Brain Germinoma

Drugs for Brain Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 2 41575-94-4 10339178 38904
2
Bleomycin Approved, Investigational Phase 2 9041-93-4, 11056-06-7 5360373
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
5 Anti-Bacterial Agents Phase 2
6 Alkylating Agents Phase 2
7 Antirheumatic Agents Phase 2
8
Etoposide phosphate Phase 2 16760419
9 Antineoplastic Agents, Alkylating Phase 2
10 Antibiotics, Antitubercular Phase 2
11 Immunosuppressive Agents Phase 2
12 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Intracranial Germinoma With Chemotherapy Prior to Reduced Dose and Volume of Radiotherapy Unknown status NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin

Search NIH Clinical Center for Brain Germinoma

Genetic Tests for Brain Germinoma

Anatomical Context for Brain Germinoma

Organs/tissues related to Brain Germinoma:

MalaCards : Brain, Medulla Oblongata, Pineal, Spinal Cord, Bone Marrow, Thalamus, Pituitary

Publications for Brain Germinoma

Articles related to Brain Germinoma:

(show top 50) (show all 302)
# Title Authors PMID Year
1
Diencephalic syndrome in a female child due to intracranial germinoma: a case report. 62
35507081 2022
2
Factors Influencing Craniospinal Relapse of Intracranial Germinoma After Complete Remission. 62
35842173 2022
3
Intracranial germinoma in the lateral ventricle with polydipsia and polyuria: a case report and literature review. 62
36271932 2022
4
Outcomes of intracranial germinoma-A retrospective multinational Asian study on effect of clinical presentation and differential treatment strategies. 62
34935949 2022
5
Radiographic Findings of an Intracranial Germinoma in a 42-Year-Old Male. 62
36060381 2022
6
Optic Nerve Germinoma and Transient Spontaneous Regression-More Than Meets the Eye. 62
34654758 2022
7
Chemotherapy plus focal radiation therapy for localized intracranial germinoma: How little is enough? 62
35171291 2022
8
Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. 62
30392398 2022
9
Studies on anti-rabphilin-3A antibodies in 15 consecutive patients presenting with central diabetes insipidus at a single referral center. 62
35292721 2022
10
The features of acute lymphocytic leukemia with intracranial germinoma in a patient with Li-Fraumeni syndrome: a case description. 62
35284289 2022
11
Vinblastine monotherapy induction prior to radiotherapy for patients with intracranial germinoma during the COVID-19 pandemic. 62
34520101 2022
12
Value of C-11 methionine PET/CT in patients with intracranial germinoma. 62
35130327 2022
13
Bifocal lesions have a poorer treatment outcome than a single lesion in adult patients with intracranial germinoma. 62
35231071 2022
14
Classification of Gliomas and Germinomas of the Basal Ganglia by Transfer Learning. 62
35311111 2022
15
Bilateral Optic Neuropathy Mimicking Neuromyelitis Optica in the Setting of Intracranial Germinoma. 62
34992988 2021
16
Primary intracranial germinoma mimicking meningioma in an elderly patient. 62
33795143 2021
17
Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae. 62
33494128 2021
18
Polymorphic Ventricular Tachycardia with QT Interval Prolongation Due to a Brain Tumor. 62
33642483 2021
19
The clinical and imaging features of infratentorial germinomas compared with supratentorial ectopic germinomas. 62
32854527 2021
20
Characteristics of growth disturbances in patients with intracranial germinomas of different origins. 62
34028562 2021
21
Letter to the Editor Regarding "Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review". 62
34243646 2021
22
Primary intracranial germ cell tumour originating from right brachium Pontis with hypertrophic Olivary degeneration: a case report. 62
34034682 2021
23
Diabetes insipidus with impaired vision caused by germinoma and perioptic meningeal seeding: A case report. 62
33748249 2021
24
Neoadjuvant Chemotherapy and Whole Ventricular Irradiation for Pure Intracranial Germinoma: A Comparison of Three Brain-Sparing Techniques. 62
33824821 2021
25
Radiotherapy-induced glioblastoma: distinct differences in overall survival, tumor location, pMGMT methylation and primary tumor epidemiology in Hong Kong chinese patients. 62
33576706 2021
26
Intracranial Germinoma Misdiagnosed as Hyperthyroidism: A Case Report and Review of the Literature. 62
35140682 2021
27
A Case of Synchronous Occurrence of Intracranial Germinoma and Systemic Sarcoidosis. 62
35079529 2021
28
The radiotherapy utilization rate in pediatric tumors: An analysis of 13,305 patients. 62
33039421 2021
29
Necessity for craniospinal irradiation of germinoma with positive cytology without spinal lesion on MR imaging-A controversy. 62
34355172 2021
30
Induction Chemotherapy Reduces Radiation Therapy Dose and Volume in the Treatment of Intracranial Germinoma: Results of the SMC-G13 Trial. 62
32502506 2020
31
A Case Report Emphasizing the Importance of Early Diagnosis and Management of Intracranial Germinoma. 62
33391952 2020
32
Optimization of Intracranial Germinoma Treatment: Radiotherapy Alone with Reduced Volume and Dose. 62
32434039 2020
33
An Unusual Case of Primary Intracranial Germinoma with Diffuse Subarachnoid Spread Masquerading as Tuberculous Meningitis. 62
33708683 2020
34
Optic atrophy secondary to intracranial germinoma. 62
32167548 2020
35
Giant intracranial germinoma. 62
32737736 2020
36
Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns. 62
32388804 2020
37
A Rare Case of a Pediatric Medullary Intracranial Germinoma. 62
32147555 2020
38
Intracranial Germinoma Masquerading as Secondary Granulomatous Hypophysitis: A Case Report and Review of Literature. 62
31269501 2020
39
Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report. 62
31776301 2019
40
Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review. 62
31295590 2019
41
Upfront chemotherapy followed by response adaptive radiotherapy for intracranial germinoma: Prospective multicenter cohort study. 62
31319280 2019
42
Primary cavernous sinus germinoma with atypical extension pattern: a case report and review of the literature. 62
30796559 2019
43
De Novo Pineal Region Germinoma in the Seventh Decade of Life: A Case Report. 62
31417835 2019
44
Rapid, label-free detection of intracranial germinoma using multiphoton microscopy. 62
31572743 2019
45
Redefining Ventricular Target Volume in Germinoma: Is Inclusion of Temporal Horns Necessary? 62
30940528 2019
46
Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution. 62
30209611 2019
47
Re-irradiation for Paediatric Tumours. 62
30385005 2019
48
Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome. 62
30738016 2019
49
A synchronous occurrence of bifocal intracranial germinoma and bilateral testicular epidermoid cyst in an adolescent patient with Klinefelter`s syndrome. 62
31916730 2019
50
Germinoma Mimicking Brain Inflammation: A Case Report. 62
31259195 2019

Variations for Brain Germinoma

Expression for Brain Germinoma

Search GEO for disease gene expression data for Brain Germinoma.

Pathways for Brain Germinoma

GO Terms for Brain Germinoma

Biological processes related to Brain Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somatic stem cell population maintenance GO:0035019 9.85 POU5F1 NANOG KIT
2 ectopic germ cell programmed cell death GO:0035234 9.73 KITLG KIT
3 embryonic hemopoiesis GO:0035162 9.71 KITLG KIT
4 stem cell population maintenance GO:0019827 9.65 PRDM14 NANOG KIT
5 endodermal cell fate specification GO:0001714 9.62 POU5F1 NANOG
6 positive regulation of mast cell proliferation GO:0070668 9.46 KITLG KIT
7 mast cell proliferation GO:0070662 9.26 KITLG KIT
8 melanocyte migration GO:0097324 8.92 KITLG KIT

Sources for Brain Germinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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