MCID: BRN031
MIFTS: 37

Brain Germinoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Germinoma

MalaCards integrated aliases for Brain Germinoma:

Name: Brain Germinoma 12 15 74
Intracranial Germinoma 12 74
Germinoma of the Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2127
NCIt 51 C6284

Summaries for Brain Germinoma

Disease Ontology : 12 A brain cancer that is characterized by abnormally proliferating cells, derives from germ cells.

MalaCards based summary : Brain Germinoma, also known as intracranial germinoma, is related to central nervous system germinoma and embryonal carcinoma. An important gene associated with Brain Germinoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Ondansetron and Granisetron have been mentioned in the context of this disorder. Affiliated tissues include brain, liver and spinal cord, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Brain Germinoma

Diseases related to Brain Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 central nervous system germinoma 32.3 AVP POU5F1
2 embryonal carcinoma 30.2 AFP POU5F1
3 seminoma 30.0 AFP POU5F1
4 teratoma 30.0 AFP POU5F1
5 embryonal testis carcinoma 30.0 AFP POU5F1
6 childhood brain germinoma 12.5
7 diabetes insipidus 10.3
8 tuberculous epididymitis 10.1 AFP AVP
9 extragonadal germ cell cancer 10.1 AFP POU5F1
10 germ cell cancer 10.1 AFP POU5F1
11 ovarian embryonal carcinoma 10.1 AFP POU5F1
12 pituitary hormone deficiency, combined, 2 10.1
13 cauda equina syndrome 10.1
14 endodermal sinus tumor 10.1
15 intratubular embryonal carcinoma 10.1 AFP POU5F1
16 oculomotor nerve paralysis 10.0 AFP AVP
17 third cranial nerve disease 10.0 AFP AVP
18 testicular infarct 10.0 AFP POU5F1
19 mature teratoma 10.0 AFP POU5F1
20 germinoma 10.0
21 embryoma 10.0 AFP POU5F1
22 pineoblastoma 10.0 AFP POU5F1
23 mixed germ cell cancer 10.0 AFP POU5F1
24 extragonadal seminoma 10.0 AFP POU5F1
25 mixed cell type cancer 9.9 AFP POU5F1
26 cornelia de lange syndrome 1 9.9
27 multiple sclerosis 9.9
28 epidermoid cysts 9.9
29 smith-lemli-opitz syndrome 9.9
30 opitz gbbb syndrome, type i 9.9
31 fryns microphthalmia syndrome 9.9
32 hypogonadotropic hypogonadism 9.9
33 cornelia de lange syndrome 9.9
34 glioblastoma multiforme 9.9
35 choriocarcinoma 9.9
36 polyradiculopathy 9.9
37 in situ carcinoma 9.9
38 hypopituitarism 9.9
39 glioblastoma 9.9
40 lymphocytic hypophysitis 9.9
41 tremor 9.9
42 growing teratoma syndrome 9.9
43 germ cell and embryonal cancer 9.9 AFP POU5F1
44 testicular yolk sac tumor 9.8 AFP POU5F1
45 central nervous system germ cell tumor 9.8 AFP AVP POU5F1
46 malignant teratoma 9.8 AFP AVP POU5F1
47 liver cirrhosis 9.7 AFP AVP
48 tracheal cancer 9.6 AFP AVP SLC5A7

Graphical network of the top 20 diseases related to Brain Germinoma:



Diseases related to Brain Germinoma

Symptoms & Phenotypes for Brain Germinoma

GenomeRNAi Phenotypes related to Brain Germinoma according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.4 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.4 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.4 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.4 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.4 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.4 AFP POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.4 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.4 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.4 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 POU5F1

MGI Mouse Phenotypes related to Brain Germinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 AFP AVP GYS1 POU5F1 SLC5A7
2 liver/biliary system MP:0005370 9.26 AFP GYS1 POU5F1 SLC5A7
3 mortality/aging MP:0010768 9.02 AFP AVP GYS1 POU5F1 SLC5A7

Drugs & Therapeutics for Brain Germinoma

Drugs for Brain Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 103)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ondansetron Approved Phase 3 99614-02-5 4595
2
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
3
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
4
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
5
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1 1177-87-3
6 Gastrointestinal Agents Phase 3,Phase 1
7 Antiemetics Phase 3,Phase 1
8 Emetics Phase 3
9 BB 1101 Phase 3,Phase 1
10 Peripheral Nervous System Agents Phase 3,Phase 1
11 Autonomic Agents Phase 3,Phase 1
12
Carboplatin Approved Phase 2,Phase 1 41575-94-4 10339178 38904 498142
13
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
14
Etoposide Approved Phase 2,Phase 1 33419-42-0 36462
15
Cyclophosphamide Approved, Investigational Phase 2,Phase 1 50-18-0, 6055-19-2 2907
16
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
17
Ifosfamide Approved Phase 2,Phase 1 3778-73-2 3690
18
Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
19
Mechlorethamine Approved, Investigational Phase 2,Phase 1 51-75-2 4033
20
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
21 Anti-Bacterial Agents Phase 2,Phase 1
22 Topoisomerase Inhibitors Phase 2,Phase 1
23 Alkylating Agents Phase 2,Phase 1
24 Immunologic Factors Phase 2,Phase 1
25 Etoposide phosphate Phase 2,Phase 1
26 Antirheumatic Agents Phase 2,Phase 1
27 Immunosuppressive Agents Phase 2,Phase 1
28 Antibiotics, Antitubercular Phase 2
29 Antineoplastic Agents, Alkylating Phase 2,Phase 1
30 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
31
Isophosphamide mustard Phase 2,Phase 1 0
32 Antimitotic Agents Phase 2,Phase 1
33 Protein Kinase Inhibitors Phase 1, Phase 2
34 Keratolytic Agents Phase 2
35 Dermatologic Agents Phase 2
36 Podophyllotoxin Phase 2 518-28-5
37 Liver Extracts Phase 1, Phase 2
38
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
39
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
40
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
41
leucovorin Approved Phase 1 58-05-9 143 6006
42
Fluorouracil Approved Phase 1 51-21-8 3385
43
Levoleucovorin Approved, Investigational Phase 1 68538-85-2
44
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 43805 6857599 5310940 9887054
45
Sunitinib Approved, Investigational Phase 1 557795-19-4, 341031-54-7 5329102
46
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
47
Vincristine Approved, Investigational Phase 1 2068-78-2, 57-22-7 5978
48
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
49
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
50
Mannitol Approved, Investigational Phase 1 69-65-8 6251 453

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
2 Chemotherapy Plus Reduced Radiotherapy in Intracranial Germinoma Unknown status NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin
3 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
4 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
5 Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Active, not recruiting NCT01602666 Phase 2 Carboplatin;Etoposide;Ifosfamide
6 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
7 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
8 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
9 Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00929903 Phase 1 pazopanib hydrochloride
10 Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
11 Sunitinib in Treating Young Patients With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
12 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
13 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
14 Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors Completed NCT00003141 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;thiotepa;vincristine sulfate
15 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
16 Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors Terminated NCT00238173 Phase 1 acetylcysteine;carboplatin;cyclophosphamide;etoposide phosphate;mannitol;sodium thiosulfate
17 Collecting and Storing Tissue From Young Patients With Cancer Completed NCT00898755
18 Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Nervous System Tumors Withdrawn NCT00897858

Search NIH Clinical Center for Brain Germinoma

Genetic Tests for Brain Germinoma

Anatomical Context for Brain Germinoma

MalaCards organs/tissues related to Brain Germinoma:

42
Brain, Liver, Spinal Cord, Bone, T Cells, Pineal, Medulla Oblongata

Publications for Brain Germinoma

Articles related to Brain Germinoma:

(show top 50) (show all 150)
# Title Authors Year
1
Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution. ( 30209611 )
2019
2
Practice patterns and survival outcomes of intracranial germinoma: an analysis of the National Cancer Database. ( 29177595 )
2018
3
Intracranial germinoma causing cerebral haemiatrophy and hypopituitarism. ( 29378909 )
2018
4
PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes. ( 29617441 )
2018
5
High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma. ( 29693779 )
2018
6
Clinical case seminar: Familial intracranial germinoma. ( 30379323 )
2018
7
Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. ( 30392398 )
2018
8
Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report. ( 30445947 )
2018
9
Adipsic diabetes insipidus revealing a bifocal intracranial germinoma. ( 28483362 )
2017
10
Atypical major depressive episode as initial presentation of intracranial germinoma in a male adolescent. ( 28053535 )
2017
11
Anomalous intracranial germinoma with unilateral cerebral peduncle swelling. ( 28283777 )
2017
12
Radiotherapy and chemotherapy plus radiation in the treatment of patients with pure intracranial germinoma: A meta-analysis. ( 28602629 )
2017
13
Intracranial Germinoma: Systemic Chemotherapy in Addition to Dose-Reduced Radiation Therapy. ( 28614087 )
2017
14
Pediatric intracranial germinoma: use chemotherapy first. ( 29044451 )
2017
15
The necessity of long-term follow-up including spinal examination after successful initial treatment of intracranial germinoma: case reports. ( 26351071 )
2016
16
Ectopic intracranial germinoma. ( 27050919 )
2016
17
Brain dose-sparing radiotherapy techniques for localized intracranial germinoma: Case report and literature review of modern irradiation. ( 27080575 )
2016
18
Atypical location of intracranial germinoma: a case report. ( 24310919 )
2015
19
Intracranial germinoma. ( 25552796 )
2015
20
Steroid-responsive intracranial germinoma presenting as Holmes' tremor: importance of a tissue diagnosis. ( 25800941 )
2015
21
False-positive (1,3) β-D-glucan assay in a patient with intracranial germinoma. ( 25851071 )
2015
22
Management of dual intracranial germinoma by radiotherapy alone. ( 25878742 )
2015
23
Results of sequential chemoradiotherapy for intracranial germinoma. ( 25943790 )
2015
24
MRI and MR spectroscopy findings of the evolution of an intracranial germinoma: A case report. ( 26622651 )
2015
25
Long-term follow-up and quality of life in patients with intracranial germinoma. ( 24715277 )
2014
26
Clinical diagnostic dilemma of intracranial germinoma manifesting as wide skull base extension. ( 25148639 )
2014
27
Treatment outcome of radiation therapy for intracranial germinoma: adaptive radiation field in relation to response to chemotherapy. ( 25275079 )
2014
28
The management of bifocal intracranial germinoma in children. ( 24092424 )
2014
29
Intracranial germinoma in the pineal region arising after subtotal resection of epidermoid cyst: case report. ( 24221216 )
2014
30
Current concepts and future strategies in the management of intracranial germinoma. ( 24224870 )
2014
31
How to interpret low human chorionic gonadotropin levels in cerebrospinal fluid of patients with intracranial germinoma? ( 24342338 )
2013
32
SIOP CNS GCT 96: final report of outcome of a prospective, multinational nonrandomized trial for children and adults with intracranial germinoma, comparing craniospinal irradiation alone with chemotherapy followed by focal primary site irradiation for patients with localized disease. ( 23460321 )
2013
33
Intracranial germinoma with leptomeningeal seeding along both trigeminal nerves. ( 23603180 )
2013
34
Effective radiotherapy cured cauda equina syndrome caused by remitted intracranial germinoma depositing. ( 23084725 )
2012
35
HESRG: a novel biomarker for intracranial germinoma and embryonal carcinoma. ( 21861197 )
2012
36
Dosimetric advantage of intensity-modulated radiotherapy for whole ventricles in the treatment of localized intracranial germinoma. ( 21640515 )
2012
37
Bifocal intracranial germinoma: a retrospective analysis of treatment outcomes in 20 patients and review of the literature. ( 21669501 )
2012
38
Multifocal intracranial germinoma with raised tumour markers in serum but not in CSF and with carcinoma in situ of the testis. ( 21859353 )
2012
39
Prognostic value of OCT4 in primary intracranial germinoma: a single institute analysis of 31 cases. ( 21973060 )
2012
40
Change in treatment strategy for intracranial germinoma: long-term follow-up experience at a single institute. ( 21989828 )
2012
41
Salvage treatment for recurrent intracranial germinoma after reduced-volume radiotherapy: a single-institution experience and review of the literature. ( 22361082 )
2012
42
Patterns of failure in patients with primary intracranial germinoma treated with neoadjuvant chemotherapy and radiotherapy. ( 22883279 )
2012
43
Intracranial germinoma manifesting as cavernous sinus syndrome--case report. ( 23095271 )
2012
44
Synchronized multiple regression of diagnostic radiation-induced rather than spontaneous: disseminated primary intracranial germinoma in a woman: a case report. ( 21272331 )
2011
45
Intracranial germinoma presenting with hemiatrophy--follow-up results and literature review--two case reports. ( 21358162 )
2011
46
Childhood intracranial germinoma with granulomatous reaction. ( 21469434 )
2011
47
Intra-abdominal metastasis of an intracranial germinoma via ventriculo-peritoneal shunt in a 13-year-old female. ( 21501064 )
2011
48
Value of brain magnetic resonance imaging and tumor markers in the diagnosis and treatment of intracranial germinoma in children. ( 21529434 )
2011
49
Brain germinoma presenting as a first psychotic episode in an adolescent male. ( 20354887 )
2010
50
Optimal treatment for intracranial germinoma: can we lower radiation dose without chemotherapy? ( 19864081 )
2010

Variations for Brain Germinoma

Expression for Brain Germinoma

Search GEO for disease gene expression data for Brain Germinoma.

Pathways for Brain Germinoma

Pathways related to Brain Germinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.42 AFP POU5F1
2 11.17 AVP POU5F1
3 10.75 AFP POU5F1

GO Terms for Brain Germinoma

Sources for Brain Germinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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