MCID: BRN031
MIFTS: 31

Brain Germinoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Germinoma

MalaCards integrated aliases for Brain Germinoma:

Name: Brain Germinoma 12 15 71
Intracranial Germinoma 12 71
Germinoma of the Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2127
NCIt 49 C6284
UMLS 71 C1332606 C1334240

Summaries for Brain Germinoma

Disease Ontology : 12 A brain cancer that is characterized by abnormally proliferating cells, derives from germ cells.

MalaCards based summary : Brain Germinoma, also known as intracranial germinoma, is related to teratoma and mixed germ cell tumor. An important gene associated with Brain Germinoma is PAGR1 (PAXIP1 Associated Glutamate Rich Protein 1). The drugs Carboplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include brain, pineal and bone.

Related Diseases for Brain Germinoma

Diseases related to Brain Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 127)
# Related Disease Score Top Affiliating Genes
1 teratoma 30.9 POU5F1 KIT AFP
2 mixed germ cell tumor 30.6 KIT AFP
3 embryonal carcinoma 30.3 POU5F1 KIT ESRG AFP
4 seminoma 30.1 POU5F1 MAGEA4 KIT AFP
5 dysgerminoma of ovary 30.1 POU5F1 KIT AFP
6 pineoblastoma 30.1 POU5F1 AFP
7 dysgerminoma 30.0 POU5F1 KIT AFP
8 endodermal sinus tumor 29.8 TFAP2C POU5F1 KIT AFP
9 germinoma 29.7 POU5F1 PAGR1 KIT ESRG AFP
10 childhood brain germinoma 12.6
11 central nervous system germinoma 12.0
12 diabetes insipidus 10.6
13 hydrocephalus 10.5
14 germ cells tumors 10.4
15 pineal region germinoma 10.4
16 mediastinum seminoma 10.4 KIT AFP
17 pineal region teratoma 10.3 KIT AFP
18 gallbladder leiomyosarcoma 10.3 KIT AFP
19 pituitary hormone deficiency, combined, 2 10.3
20 obstructive hydrocephalus 10.3
21 hypopituitarism 10.3
22 gonadoblastoma 10.3 POU5F1 KIT
23 liver leiomyoma 10.3 KIT AFP
24 mixed germ cell cancer 10.3 KIT AFP
25 pediatric testicular germ cell tumor 10.3 POU5F1 AFP
26 ovarian mixed germ cell neoplasm 10.3 KIT AFP
27 ovarian embryonal carcinoma 10.3 POU5F1 AFP
28 hepatic angiomyolipoma 10.3 KIT AFP
29 ovarian endodermal sinus tumor 10.3 POU5F1 AFP
30 liver leiomyosarcoma 10.2 KIT AFP
31 ovarian primitive germ cell tumor 10.2 POU5F1 AFP
32 sarcomatous intrahepatic cholangiocarcinoma 10.2 KIT AFP
33 endometrial small cell carcinoma 10.2 KIT AFP
34 mediastinal cancer 10.2 KIT AFP
35 ataxia and polyneuropathy, adult-onset 10.2
36 choriocarcinoma 10.2
37 growth hormone deficiency 10.2
38 mixed cell type cancer 10.1 KIT AFP
39 intratubular embryonal carcinoma 10.1 POU5F1 KIT AFP
40 ovarian gonadoblastoma 10.1 POU5F1 KIT AFP
41 ovarian germ cell cancer 10.1 POU5F1 KIT AFP
42 mature teratoma 10.1 POU5F1 KIT AFP
43 cystic teratoma 10.1 KIT AFP
44 germ cell and embryonal cancer 10.1 POU5F1 KIT AFP
45 epidermoid cysts 10.1
46 down syndrome 10.1
47 3-methylglutaconic aciduria, type iii 10.1
48 meningioma, radiation-induced 10.1
49 meningioma, familial 10.1
50 spinal meningioma 10.1

Graphical network of the top 20 diseases related to Brain Germinoma:



Diseases related to Brain Germinoma

Symptoms & Phenotypes for Brain Germinoma

Drugs & Therapeutics for Brain Germinoma

Drugs for Brain Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
2
Etoposide Approved Phase 3 33419-42-0 36462
3
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
4
Ifosfamide Approved Phase 3 3778-73-2 3690
5 Etoposide phosphate Phase 3
6 Alkylating Agents Phase 3
7
Isophosphamide mustard Phase 3 0
8
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
9
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
10 Immunosuppressive Agents Phase 2
11 Anti-Bacterial Agents Phase 2
12 Immunologic Factors Phase 2
13 Antirheumatic Agents Phase 2
14 Antibiotics, Antitubercular Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 SIOP Intracranial Germ Cell Tumours Protocol Completed NCT00293358 Phase 3 carboplatin;cisplatin;etoposide phosphate;ifosfamide
2 Treatment of Intracranial Germinoma With Chemotherapy Prior to Reduced Dose and Volume of Radiotherapy Unknown status NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin

Search NIH Clinical Center for Brain Germinoma

Genetic Tests for Brain Germinoma

Anatomical Context for Brain Germinoma

MalaCards organs/tissues related to Brain Germinoma:

40
Brain, Pineal, Bone, Medulla Oblongata, Spinal Cord, Pituitary, Bone Marrow

Publications for Brain Germinoma

Articles related to Brain Germinoma:

(show top 50) (show all 268)
# Title Authors PMID Year
1
A Rare Case of a Pediatric Medullary Intracranial Germinoma. 61
32147555 2020
2
Induction chemotherapy reduces radiotherapy dose and volume in the treatment of intracranial germinoma: Results of the SMC-G13 trial. 61
32502506 2020
3
Optimization of intracranial germinoma treatment: A single-institution experience with 213 patients supports the use of radiotherapy alone with reduced volume and dose. 61
32434039 2020
4
Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns. 61
32388804 2020
5
Optic Atrophy Secondary to Intracranial Germinoma. 61
32167548 2020
6
Intracranial Germinoma Masquerading as Secondary Granulomatous Hypophysitis: A Case Report and Review of Literature. 61
31269501 2020
7
Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report. 61
31776301 2019
8
Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review. 61
31295590 2019
9
Upfront chemotherapy followed by response adaptive radiotherapy for intracranial germinoma: Prospective multicenter cohort study. 61
31319280 2019
10
Primary cavernous sinus germinoma with atypical extension pattern: a case report and review of the literature. 61
30796559 2019
11
De Novo Pineal Region Germinoma in the Seventh Decade of Life: A Case Report. 61
31417835 2019
12
Rapid, label-free detection of intracranial germinoma using multiphoton microscopy. 61
31572743 2019
13
Redefining Ventricular Target Volume in Germinoma: Is Inclusion of Temporal Horns Necessary? 61
30940528 2019
14
Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution. 61
30209611 2019
15
Re-irradiation for Paediatric Tumours. 61
30385005 2019
16
Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome. 61
30738016 2019
17
A synchronous occurrence of bifocal intracranial germinoma and bilateral testicular epidermoid cyst in an adolescent patient with Klinefelter`s syndrome. 61
31916730 2019
18
Treatment outcomes based on radiation therapy fields for bifocal germinoma: Synchronous or disseminated disease? 61
31581215 2019
19
Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. 61
30392398 2018
20
Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report. 61
30445947 2018
21
Placental alkaline phosphatase levels in cerebrospinal fluid can have a decisive role in the differential diagnosis of intracranial germ cell tumors. 61
30265190 2018
22
High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma. 61
29693779 2018
23
Intracranial germinoma causing cerebral haemiatrophy and hypopituitarism. 61
29378909 2018
24
Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. 61
29682040 2018
25
Practice patterns and survival outcomes of intracranial germinoma: an analysis of the National Cancer Database. 61
29177595 2018
26
Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. 61
29492156 2018
27
Clinical case seminar: Familial intracranial germinoma. 61
30379323 2018
28
PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes. 61
29617441 2018
29
A rare case report and literatures review on primary germinoma in cerebellar hemisphere. 61
28689343 2017
30
Visual complaints in intracranial germinomas. 61
28436607 2017
31
Intracranial Germinoma: Systemic Chemotherapy in Addition to Dose-Reduced Radiation Therapy. 61
28614087 2017
32
Radiotherapy and chemotherapy plus radiation in the treatment of patients with pure intracranial germinoma: A meta-analysis. 61
28602629 2017
33
Pediatric intracranial germinoma: use chemotherapy first. 61
29044451 2017
34
Adipsic diabetes insipidus revealing a bifocal intracranial germinoma. 61
28483362 2017
35
Anomalous intracranial germinoma with unilateral cerebral peduncle swelling. 61
28283777 2017
36
Craniospinal irradiation using helical tomotherapy for central nervous system tumors. 61
28096196 2017
37
Efficacy of Ifosfamide-Cisplatin-Etoposide (ICE) Chemotherapy for a CNS Germinoma in a Child With Down Syndrome. 61
27879538 2017
38
Atypical major depressive episode as initial presentation of intracranial germinoma in a male adolescent. 61
28053535 2017
39
[Biomarker of the intracranial germinoma -New tumor marker'PLAP for the intracranial germinoma-]. 61
30634789 2016
40
Ectopic intracranial germinoma. 61
27050919 2016
41
Basal Ganglia Germinoma in an Adult. 61
27241091 2016
42
Brain dose-sparing radiotherapy techniques for localized intracranial germinoma: Case report and literature review of modern irradiation. 61
27080575 2016
43
Preservation of KIT genotype in a novel pair of patient-derived orthotopic xenograft mouse models of metastatic pediatric CNS germinoma. 61
26956263 2016
44
Outcomes of children with central nervous system germinoma treated with multi-agent chemotherapy followed by reduced radiation. 61
26744133 2016
45
The necessity of long-term follow-up including spinal examination after successful initial treatment of intracranial germinoma: case reports. 61
26351071 2016
46
Determining an Optimal Cutoff of Serum β-Human Chorionic Gonadotropin for Assisting the Diagnosis of Intracranial Germinomas. 61
26771195 2016
47
Germinoma Mimicking Tumefactive Demyelinating Disease in Pediatric Patients. 61
26811911 2016
48
Successful Treatment of Intracranial Germ Cell Tumor: Report of Two Unusual Cases and Literature Review. 61
26668575 2015
49
MRI and MR spectroscopy findings of the evolution of an intracranial germinoma: A case report. 61
26622651 2015
50
False-positive (1,3) β-D-glucan assay in a patient with intracranial germinoma. 61
25851071 2015

Variations for Brain Germinoma

Expression for Brain Germinoma

Search GEO for disease gene expression data for Brain Germinoma.

Pathways for Brain Germinoma

GO Terms for Brain Germinoma

Biological processes related to Brain Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 9.16 SPRY4 PRDM14
2 regulation of gene expression, epigenetic GO:0040029 8.96 TFAP2C PRDM14
3 somatic stem cell population maintenance GO:0035019 8.8 PRDM14 POU5F1 KIT

Molecular functions related to Brain Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 8.62 POU5F1 KIT

Sources for Brain Germinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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