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MCID: BRN031
MIFTS: 34

Brain Germinoma

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Brain Germinoma

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MalaCards integrated aliases for Brain Germinoma:

Name: Brain Germinoma 12 15 74
Intracranial Germinoma 12 74
Germinoma of the Brain 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2127
NCIt 51 C6284
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Summaries for Brain Germinoma

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Disease Ontology : 12 A brain cancer that is characterized by abnormally proliferating cells, derives from germ cells.

MalaCards based summary : Brain Germinoma, also known as intracranial germinoma, is related to central nervous system germinoma and embryonal carcinoma. An important gene associated with Brain Germinoma is AFP (Alpha Fetoprotein), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Ondansetron and Granisetron have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Brain Germinoma

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Diseases related to Brain Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 central nervous system germinoma 32.2 AVP POU5F1
2 embryonal carcinoma 30.2 AFP POU5F1
3 seminoma 30.0 AFP POU5F1
4 teratoma 30.0 AFP POU5F1
5 embryonal testis carcinoma 30.0 AFP POU5F1
6 childhood brain germinoma 12.5
7 diabetes insipidus 10.3
8 germinoma 10.1
9 tuberculous epididymitis 10.1 AFP AVP
10 extragonadal germ cell cancer 10.1 AFP POU5F1
11 germ cell cancer 10.1 AFP POU5F1
12 multiple sclerosis 10.1
13 ovarian embryonal carcinoma 10.1 AFP POU5F1
14 intratubular embryonal carcinoma 10.1 AFP POU5F1
15 oculomotor nerve paralysis 10.0 AFP AVP
16 third cranial nerve disease 10.0 AFP AVP
17 testicular infarct 10.0 AFP POU5F1
18 mature teratoma 10.0 AFP POU5F1
19 embryoma 10.0 AFP POU5F1
20 pineoblastoma 10.0 AFP POU5F1
21 mixed germ cell cancer 10.0 AFP POU5F1
22 extragonadal seminoma 10.0 AFP POU5F1
23 mixed cell type cancer 9.9 AFP POU5F1
24 epidermoid cysts 9.9
25 smith-lemli-opitz syndrome 9.9
26 opitz gbbb syndrome, type i 9.9
27 hypogonadotropic hypogonadism 9.9
28 cauda equina syndrome 9.9
29 cornelia de lange syndrome 9.9
30 glioblastoma multiforme 9.9
31 choriocarcinoma 9.9
32 polyradiculopathy 9.9
33 in situ carcinoma 9.9
34 hypopituitarism 9.9
35 glioblastoma 9.9
36 lymphocytic hypophysitis 9.9
37 tremor 9.9
38 growing teratoma syndrome 9.9
39 germ cell and embryonal cancer 9.9 AFP POU5F1
40 testicular yolk sac tumor 9.8 AFP POU5F1
41 central nervous system germ cell tumor 9.8 AFP AVP POU5F1
42 malignant teratoma 9.8 AFP AVP POU5F1
43 liver cirrhosis 9.7 AFP AVP
44 tracheal cancer 9.6 AFP AVP SLC5A7

Graphical network of the top 20 diseases related to Brain Germinoma:



Diseases related to Brain Germinoma
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Symptoms & Phenotypes for Brain Germinoma

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GenomeRNAi Phenotypes related to Brain Germinoma according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.4 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.4 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.4 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.4 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.4 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.4 AFP POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.4 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.4 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.4 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 POU5F1

MGI Mouse Phenotypes related to Brain Germinoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 AFP AVP GYS1 POU5F1 SLC5A7
2 liver/biliary system MP:0005370 9.26 AFP GYS1 POU5F1 SLC5A7
3 mortality/aging MP:0010768 9.02 AFP AVP GYS1 POU5F1 SLC5A7
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Drugs & Therapeutics for Brain Germinoma

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Drugs for Brain Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 103)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ondansetron Approved Phase 3 99614-02-5 4595
2
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
3
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 441203 84093 2767
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 1 1177-87-3
5
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
6 Emetics Phase 3
7 Peripheral Nervous System Agents Phase 3,Phase 1
8 Autonomic Agents Phase 3,Phase 1
9 BB 1101 Phase 3,Phase 1
10 Antiemetics Phase 3,Phase 1
11 Gastrointestinal Agents Phase 3,Phase 1
12
Etoposide Approved Phase 2,Phase 1 33419-42-0 36462
13
Carboplatin Approved Phase 2,Phase 1 41575-94-4 38904 10339178 498142
14
Cyclophosphamide Approved, Investigational Phase 2,Phase 1 6055-19-2, 50-18-0 2907
15
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
16
Ifosfamide Approved Phase 2,Phase 1 3778-73-2 3690
17
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
18
Mechlorethamine Approved, Investigational Phase 2,Phase 1 51-75-2 4033
19
Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
20
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
21 Antirheumatic Agents Phase 2,Phase 1
22 Antineoplastic Agents, Phytogenic Phase 2,Phase 1
23 Alkylating Agents Phase 2,Phase 1
24 Antibiotics, Antitubercular Phase 2
25 Immunologic Factors Phase 2,Phase 1
26 Topoisomerase Inhibitors Phase 2,Phase 1
27 Etoposide phosphate Phase 2,Phase 1
28 Immunosuppressive Agents Phase 2,Phase 1
29 Anti-Bacterial Agents Phase 2,Phase 1
30 Antineoplastic Agents, Alkylating Phase 2,Phase 1
31
Isophosphamide mustard Phase 2,Phase 1 0
32 Antimitotic Agents Phase 2,Phase 1
33 Protein Kinase Inhibitors Phase 1, Phase 2
34 Keratolytic Agents Phase 2
35 Dermatologic Agents Phase 2
36 Podophyllotoxin Phase 2 518-28-5
37 Liver Extracts Phase 1, Phase 2
38
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
39
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
40
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
41
Fluorouracil Approved Phase 1 51-21-8 3385
42
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 6857599 5310940 9887054 43805
43
Levoleucovorin Approved, Investigational Phase 1 68538-85-2
44
leucovorin Approved Phase 1 58-05-9 6006 143
45
Sunitinib Approved, Investigational Phase 1 557795-19-4, 341031-54-7 5329102
46
Nicotinamide Approved, Investigational Phase 1 98-92-0 936
47
Vincristine Approved, Investigational Phase 1 2068-78-2, 57-22-7 5978
48
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
49
Mannitol Approved, Investigational Phase 1 69-65-8 453 6251
50
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
2 Chemotherapy Plus Reduced Radiotherapy in Intracranial Germinoma Unknown status NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin
3 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
4 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
5 Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Active, not recruiting NCT01602666 Phase 2 Carboplatin;Etoposide;Ifosfamide
6 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
7 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
8 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
9 Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00929903 Phase 1 pazopanib hydrochloride
10 Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
11 Sunitinib in Treating Young Patients With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
12 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
13 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
14 Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors Completed NCT00003141 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;thiotepa;vincristine sulfate
15 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
16 Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors Terminated NCT00238173 Phase 1 acetylcysteine;carboplatin;cyclophosphamide;etoposide phosphate;mannitol;sodium thiosulfate
17 Collecting and Storing Tissue From Young Patients With Cancer Completed NCT00898755
18 Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Nervous System Tumors Withdrawn NCT00897858

Search NIH Clinical Center for Brain Germinoma

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Genetic Tests for Brain Germinoma

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Anatomical Context for Brain Germinoma

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MalaCards organs/tissues related to Brain Germinoma:

42
Brain, Spinal Cord, Liver, Bone, T Cells
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Publications for Brain Germinoma

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Articles related to Brain Germinoma:

(show all 16)
# Title Authors Year
1
Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. ( 30392398 )
2018
2
Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report. ( 30445947 )
2018
3
Practice patterns and survival outcomes of intracranial germinoma: an analysis of the National Cancer Database. ( 29177595 )
2018
4
PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes. ( 29617441 )
2018
5
High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma. ( 29693779 )
2018
6
Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution. ( 30209611 )
2018
7
Clinical case seminar: Familial intracranial germinoma. ( 30379323 )
2018
8
Adipsic diabetes insipidus revealing a bifocal intracranial germinoma. ( 28483362 )
2017
9
Atypical major depressive episode as initial presentation of intracranial germinoma in a male adolescent. ( 28053535 )
2017
10
Anomalous intracranial germinoma with unilateral cerebral peduncle swelling. ( 28283777 )
2017
11
Radiotherapy and chemotherapy plus radiation in the treatment of patients with pure intracranial germinoma: A meta-analysis. ( 28602629 )
2017
12
Intracranial Germinoma: Systemic Chemotherapy in Addition to Dose-Reduced Radiation Therapy. ( 28614087 )
2017
13
Pediatric intracranial germinoma: use chemotherapy first. ( 29044451 )
2017
14
Brain germinoma presenting as a first psychotic episode in an adolescent male. ( 20354887 )
2010
15
Brain germinoma in a young adult man with suspicion of fatal neglect. ( 19465813 )
2009
16
Some new observations in an intracranial germinoma. ( 170774 )
1975
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Variations for Brain Germinoma

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Expression for Brain Germinoma

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Search GEO for disease gene expression data for Brain Germinoma.
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Pathways for Brain Germinoma

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Pathways related to Brain Germinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Wnt / Hedgehog / Notch 4
11.42 AFP POU5F1
2
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.17 AVP POU5F1
3
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 66
10.75 AFP POU5F1
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GO Terms for Brain Germinoma

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Sources for Brain Germinoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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