MCID: BRN031
MIFTS: 31

Brain Germinoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Germinoma

MalaCards integrated aliases for Brain Germinoma:

Name: Brain Germinoma 12 15 73
Intracranial Germinoma 12 73
Germinoma of the Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2127
NCIt 50 C6284

Summaries for Brain Germinoma

Disease Ontology : 12 A brain cancer that is characterized by abnormally proliferating cells, derives from germ cells.

MalaCards based summary : Brain Germinoma, also known as intracranial germinoma, is related to central nervous system germinoma and embryonal carcinoma. An important gene associated with Brain Germinoma is AVP (Arginine Vasopressin), and among its related pathways/superpathways are Wnt / Hedgehog / Notch and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. Affiliated tissues include brain, testis and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Brain Germinoma

Diseases related to Brain Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 central nervous system germinoma 32.2 AVP POU5F1
2 embryonal carcinoma 30.1 AFP POU5F1
3 seminoma 30.0 AFP POU5F1
4 teratoma 29.9 AFP POU5F1
5 embryonal testis carcinoma 29.9 AFP POU5F1
6 childhood brain germinoma 12.5
7 diabetes insipidus 10.2
8 tuberculous epididymitis 10.1 AFP AVP
9 multiple sclerosis 10.0
10 endodermal sinus tumor 10.0
11 oculomotor nerve paralysis 10.0 AFP AVP
12 extragonadal germ cell cancer 10.0 AFP POU5F1
13 third cranial nerve disease 10.0 AFP AVP
14 germ cell cancer 10.0 AFP POU5F1
15 ovarian embryonal carcinoma 10.0 AFP POU5F1
16 intratubular embryonal carcinoma 10.0 AFP POU5F1
17 testicular infarct 10.0 AFP POU5F1
18 mature teratoma 10.0 AFP POU5F1
19 embryoma 10.0 AFP POU5F1
20 pineoblastoma 10.0 AFP POU5F1
21 mixed germ cell cancer 10.0 AFP POU5F1
22 extragonadal seminoma 10.0 AFP POU5F1
23 mixed cell type cancer 9.9 AFP POU5F1
24 germ cell and embryonal cancer 9.9 AFP POU5F1
25 epidermoid cysts 9.9
26 pituitary hormone deficiency, combined, 2 9.9
27 smith-lemli-opitz syndrome 9.9
28 opitz gbbb syndrome, type i 9.9
29 hypogonadotropic hypogonadism 9.9
30 cauda equina syndrome 9.9
31 cornelia de lange syndrome 9.9
32 glioblastoma multiforme 9.9
33 choriocarcinoma 9.9
34 polyradiculopathy 9.9
35 in situ carcinoma 9.9
36 hypopituitarism 9.9
37 glioblastoma 9.9
38 lymphocytic hypophysitis 9.9
39 tremor 9.9
40 growing teratoma syndrome 9.9
41 central nervous system germ cell tumor 9.9 AFP AVP POU5F1
42 malignant teratoma 9.9 AFP AVP POU5F1
43 testicular yolk sac tumor 9.9 AFP POU5F1
44 liver cirrhosis 9.8 AFP AVP
45 tracheal cancer 9.8 AFP AVP SLC5A7

Graphical network of the top 20 diseases related to Brain Germinoma:



Diseases related to Brain Germinoma

Symptoms & Phenotypes for Brain Germinoma

GenomeRNAi Phenotypes related to Brain Germinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.36 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.36 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.36 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.36 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.36 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.36 AFP POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.36 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.36 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.36 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.36 POU5F1

MGI Mouse Phenotypes related to Brain Germinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 AFP AVP GYS1 POU5F1 SLC5A7
2 liver/biliary system MP:0005370 9.26 AFP GYS1 POU5F1 SLC5A7
3 mortality/aging MP:0010768 9.02 AFP AVP GYS1 POU5F1 SLC5A7

Drugs & Therapeutics for Brain Germinoma

Search Clinical Trials , NIH Clinical Center for Brain Germinoma

Genetic Tests for Brain Germinoma

Anatomical Context for Brain Germinoma

MalaCards organs/tissues related to Brain Germinoma:

41
Brain, Testis, Liver, Pineal

Publications for Brain Germinoma

Articles related to Brain Germinoma:

(show all 23)
# Title Authors Year
1
Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report. ( 30445947 )
2018
2
Practice patterns and survival outcomes of intracranial germinoma: an analysis of the National Cancer Database. ( 29177595 )
2018
3
PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes. ( 29617441 )
2018
4
High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma. ( 29693779 )
2018
5
Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution. ( 30209611 )
2018
6
Clinical case seminar: Familial intracranial germinoma. ( 30379323 )
2018
7
Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. ( 30392398 )
2018
8
Adipsic diabetes insipidus revealing a bifocal intracranial germinoma. ( 28483362 )
2017
9
Atypical major depressive episode as initial presentation of intracranial germinoma in a male adolescent. ( 28053535 )
2017
10
Anomalous intracranial germinoma with unilateral cerebral peduncle swelling. ( 28283777 )
2017
11
Radiotherapy and chemotherapy plus radiation in the treatment of patients with pure intracranial germinoma: A meta-analysis. ( 28602629 )
2017
12
Intracranial Germinoma: Systemic Chemotherapy in Addition to Dose-Reduced Radiation Therapy. ( 28614087 )
2017
13
Pediatric intracranial germinoma: use chemotherapy first. ( 29044451 )
2017
14
The necessity of long-term follow-up including spinal examination after successful initial treatment of intracranial germinoma: case reports. ( 26351071 )
2016
15
Intracranial germinoma in the pineal region arising after subtotal resection of epidermoid cyst: case report. ( 24221216 )
2014
16
Multifocal intracranial germinoma with raised tumour markers in serum but not in CSF and with carcinoma in situ of the testis. ( 21859353 )
2012
17
Brain germinoma presenting as a first psychotic episode in an adolescent male. ( 20354887 )
2010
18
Optimal treatment for intracranial germinoma: can we lower radiation dose without chemotherapy? ( 19864081 )
2010
19
Intracranial germinoma: clinical and MRI findings in 56 patients. ( 20665036 )
2010
20
Brain germinoma in a young adult man with suspicion of fatal neglect. ( 19465813 )
2009
21
Lymphocytic hypophysitis with central diabetes insipidus and consequent panhypopituitarism preceding a multifocal, intracranial germinoma in a prepubertal girl. ( 10206125 )
1999
22
Reduction of the radiation dose for intracranial germinoma: a prospective study. ( 7947108 )
1994
23
Some new observations in an intracranial germinoma. ( 170774 )
1975

Variations for Brain Germinoma

Expression for Brain Germinoma

Search GEO for disease gene expression data for Brain Germinoma.

Pathways for Brain Germinoma

Pathways related to Brain Germinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.42 AFP POU5F1
2 11.17 AVP POU5F1
3 10.75 AFP POU5F1

GO Terms for Brain Germinoma

Sources for Brain Germinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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