MCID: BRN031
MIFTS: 31

Brain Germinoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Germinoma

MalaCards integrated aliases for Brain Germinoma:

Name: Brain Germinoma 12 15 70
Intracranial Germinoma 12 70
Germinoma of the Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2127
NCIt 50 C6284
UMLS 70 C1332606 C1334240

Summaries for Brain Germinoma

Disease Ontology : 12 A brain cancer that is characterized by abnormally proliferating cells, derives from germ cells.

MalaCards based summary : Brain Germinoma, also known as intracranial germinoma, is related to teratoma and mixed germ cell tumor. An important gene associated with Brain Germinoma is PAGR1 (PAXIP1 Associated Glutamate Rich Protein 1). The drugs Etoposide and Bleomycin have been mentioned in the context of this disorder. Affiliated tissues include brain, pineal and bone.

Related Diseases for Brain Germinoma

Diseases related to Brain Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 125)
# Related Disease Score Top Affiliating Genes
1 teratoma 30.6 POU5F1 KIT AFP
2 mixed germ cell tumor 30.5 KIT AFP
3 dysgerminoma 30.4 KIT AFP
4 embryonal carcinoma 30.3 POU5F1 KIT ESRG AFP
5 seminoma 30.1 POU5F1 MAGEA4 KIT AFP
6 dysgerminoma of ovary 30.0 POU5F1 KIT AFP
7 pineoblastoma 30.0 POU5F1 AFP
8 germinoma 29.8 POU5F1 PAGR1 KIT ESRG AFP
9 central nervous system germinoma 11.5
10 childhood brain germinoma 11.5
11 diabetes insipidus 10.5
12 germ cells tumors 10.4
13 hydrocephalus 10.4
14 pineal region germinoma 10.4
15 pituitary hormone deficiency, combined, 2 10.3
16 mediastinum seminoma 10.3 KIT AFP
17 pineal region teratoma 10.3 KIT AFP
18 gallbladder leiomyosarcoma 10.3 KIT AFP
19 gonadoblastoma 10.2 POU5F1 KIT
20 liver leiomyoma 10.2 KIT AFP
21 obstructive hydrocephalus 10.2
22 hypopituitarism 10.2
23 esophageal adenoid cystic carcinoma 10.2 KIT AFP
24 pediatric testicular germ cell tumor 10.2 POU5F1 AFP
25 mixed germ cell cancer 10.2 KIT AFP
26 ovarian mixed germ cell neoplasm 10.2 KIT AFP
27 ovarian embryonal carcinoma 10.2 POU5F1 AFP
28 sarcomatous intrahepatic cholangiocarcinoma 10.2 KIT AFP
29 ovarian primitive germ cell tumor 10.2 POU5F1 AFP
30 endometrial small cell carcinoma 10.2 KIT AFP
31 ovarian endodermal sinus tumor 10.2 POU5F1 AFP
32 liver leiomyosarcoma 10.2 KIT AFP
33 mediastinal cancer 10.2 KIT AFP
34 ovarian germ cell cancer 10.2 KIT AFP
35 seminal vesicle adenocarcinoma 10.1 KIT AFP
36 chromosome 16p11.2 deletion syndrome 10.1 PAGR1 CDIPTOSP
37 ataxia and polyneuropathy, adult-onset 10.1
38 growth hormone deficiency 10.1
39 intratubular embryonal carcinoma 10.1 POU5F1 KIT AFP
40 ovarian gonadoblastoma 10.1 POU5F1 KIT AFP
41 malignant teratoma 10.1 POU5F1 KIT AFP
42 mature teratoma 10.1 POU5F1 KIT AFP
43 germ cell and embryonal cancer 10.1 POU5F1 KIT AFP
44 mixed cell type cancer 10.1 KIT AFP
45 extragonadal seminoma 10.1 TFAP2C KIT AFP
46 epidermoid cysts 10.0
47 down syndrome 10.0
48 meningioma, familial 10.0
49 intracranial meningioma 10.0
50 cauda equina syndrome 10.0

Graphical network of the top 20 diseases related to Brain Germinoma:



Diseases related to Brain Germinoma

Symptoms & Phenotypes for Brain Germinoma

Drugs & Therapeutics for Brain Germinoma

Drugs for Brain Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
3
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
4
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
5 Antibiotics, Antitubercular Phase 2
6 Etoposide phosphate Phase 2
7 Immunosuppressive Agents Phase 2
8 Antirheumatic Agents Phase 2
9 Immunologic Factors Phase 2
10 Alkylating Agents Phase 2
11 Anti-Bacterial Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Intracranial Germinoma With Chemotherapy Prior to Reduced Dose and Volume of Radiotherapy Unknown status NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin

Search NIH Clinical Center for Brain Germinoma

Genetic Tests for Brain Germinoma

Anatomical Context for Brain Germinoma

MalaCards organs/tissues related to Brain Germinoma:

40
Brain, Pineal, Bone, Medulla Oblongata, Spinal Cord, Pituitary, Bone Marrow

Publications for Brain Germinoma

Articles related to Brain Germinoma:

(show top 50) (show all 278)
# Title Authors PMID Year
1
Polymorphic Ventricular Tachycardia with QT Interval Prolongation Due to a Brain Tumor. 61
33642483 2021
2
Primary intracranial germinoma mimicking meningioma in an elderly patient. 61
33795143 2021
3
Diabetes insipidus with impaired vision caused by germinoma and perioptic meningeal seeding: A case report. 61
33748249 2021
4
Radiotherapy-induced glioblastoma: distinct differences in overall survival, tumor location, pMGMT methylation and primary tumor epidemiology in Hong Kong chinese patients. 61
33576706 2021
5
The radiotherapy utilization rate in pediatric tumors: An analysis of 13,305 patients. 61
33039421 2021
6
Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae. 61
33494128 2021
7
Induction Chemotherapy Reduces Radiation Therapy Dose and Volume in the Treatment of Intracranial Germinoma: Results of the SMC-G13 Trial. 61
32502506 2020
8
A Case Report Emphasizing the Importance of Early Diagnosis and Management of Intracranial Germinoma. 61
33391952 2020
9
Optimization of Intracranial Germinoma Treatment: Radiotherapy Alone with Reduced Volume and Dose. 61
32434039 2020
10
An Unusual Case of Primary Intracranial Germinoma with Diffuse Subarachnoid Spread Masquerading as Tuberculous Meningitis. 61
33708683 2020
11
Optic atrophy secondary to intracranial germinoma. 61
32167548 2020
12
Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns. 61
32388804 2020
13
The clinical and imaging features of infratentorial germinomas compared with supratentorial ectopic germinomas. 61
32854527 2020
14
Giant intracranial germinoma. 61
32737736 2020
15
A Rare Case of a Pediatric Medullary Intracranial Germinoma. 61
32147555 2020
16
Intracranial Germinoma Masquerading as Secondary Granulomatous Hypophysitis: A Case Report and Review of Literature. 61
31269501 2020
17
Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report. 61
31776301 2019
18
Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review. 61
31295590 2019
19
Upfront chemotherapy followed by response adaptive radiotherapy for intracranial germinoma: Prospective multicenter cohort study. 61
31319280 2019
20
Primary cavernous sinus germinoma with atypical extension pattern: a case report and review of the literature. 61
30796559 2019
21
De Novo Pineal Region Germinoma in the Seventh Decade of Life: A Case Report. 61
31417835 2019
22
Rapid, label-free detection of intracranial germinoma using multiphoton microscopy. 61
31572743 2019
23
Redefining Ventricular Target Volume in Germinoma: Is Inclusion of Temporal Horns Necessary? 61
30940528 2019
24
Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution. 61
30209611 2019
25
Re-irradiation for Paediatric Tumours. 61
30385005 2019
26
Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome. 61
30738016 2019
27
Treatment outcomes based on radiation therapy fields for bifocal germinoma: Synchronous or disseminated disease? 61
31581215 2019
28
A synchronous occurrence of bifocal intracranial germinoma and bilateral testicular epidermoid cyst in an adolescent patient with Klinefelter`s syndrome. 61
31916730 2019
29
Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. 61
30392398 2018
30
Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report. 61
30445947 2018
31
Placental alkaline phosphatase levels in cerebrospinal fluid can have a decisive role in the differential diagnosis of intracranial germ cell tumors. 61
30265190 2018
32
Intracranial germinoma causing cerebral haemiatrophy and hypopituitarism. 61
29378909 2018
33
High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma. 61
29693779 2018
34
Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. 61
29682040 2018
35
Practice patterns and survival outcomes of intracranial germinoma: an analysis of the National Cancer Database. 61
29177595 2018
36
PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes. 61
29617441 2018
37
Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. 61
29492156 2018
38
Clinical case seminar: Familial intracranial germinoma. 61
30379323 2018
39
A rare case report and literatures review on primary germinoma in cerebellar hemisphere. 61
28689343 2017
40
Visual complaints in intracranial germinomas. 61
28436607 2017
41
Intracranial Germinoma: Systemic Chemotherapy in Addition to Dose-Reduced Radiation Therapy. 61
28614087 2017
42
Radiotherapy and chemotherapy plus radiation in the treatment of patients with pure intracranial germinoma: A meta-analysis. 61
28602629 2017
43
Pediatric intracranial germinoma: use chemotherapy first. 61
29044451 2017
44
Adipsic diabetes insipidus revealing a bifocal intracranial germinoma. 61
28483362 2017
45
Anomalous intracranial germinoma with unilateral cerebral peduncle swelling. 61
28283777 2017
46
Craniospinal irradiation using helical tomotherapy for central nervous system tumors. 61
28096196 2017
47
Efficacy of Ifosfamide-Cisplatin-Etoposide (ICE) Chemotherapy for a CNS Germinoma in a Child With Down Syndrome. 61
27879538 2017
48
Atypical major depressive episode as initial presentation of intracranial germinoma in a male adolescent. 61
28053535 2017
49
[Biomarker of the intracranial germinoma -New tumor marker'PLAP for the intracranial germinoma-]. 61
30634789 2016
50
Ectopic intracranial germinoma. 61
27050919 2016

Variations for Brain Germinoma

Expression for Brain Germinoma

Search GEO for disease gene expression data for Brain Germinoma.

Pathways for Brain Germinoma

GO Terms for Brain Germinoma

Biological processes related to Brain Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 germ cell development GO:0007281 9.26 PRDM14 NANOS3
2 negative regulation of fibroblast growth factor receptor signaling pathway GO:0040037 9.16 SPRY4 PRDM14
3 regulation of gene expression, epigenetic GO:0040029 8.96 TFAP2C PRDM14
4 somatic stem cell population maintenance GO:0035019 8.8 PRDM14 POU5F1 KIT

Molecular functions related to Brain Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine binding GO:0019955 8.62 POU5F1 KIT

Sources for Brain Germinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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