MCID: BRN005
MIFTS: 34

Brain Glioblastoma Multiforme

Categories: Cancer diseases, Mental diseases, Neuronal diseases

Aliases & Classifications for Brain Glioblastoma Multiforme

MalaCards integrated aliases for Brain Glioblastoma Multiforme:

Name: Brain Glioblastoma Multiforme 12 15 37
Glioblastoma Multiforme of Brain 12 70
Brain Glioblastoma 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:3073
NCIt 50 C4642
SNOMED-CT 67 276828006
UMLS 70 C0349543

Summaries for Brain Glioblastoma Multiforme

Disease Ontology : 12 A brain glioma that has material basis in abnormally proliferating cells derives from glial cells, has symptom seizure, headaches, nausea and vomiting, memory loss, changes to personality, mood or concentration; and localized neurological problems.

MalaCards based summary : Brain Glioblastoma Multiforme, also known as glioblastoma multiforme of brain, is related to malignant astrocytoma and glioblastoma, and has symptoms including seizure, seizures and headache. An important gene associated with Brain Glioblastoma Multiforme is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Spinal Cord Injury. The drugs Belinostat and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and spinal cord.

Related Diseases for Brain Glioblastoma Multiforme

Graphical network of the top 20 diseases related to Brain Glioblastoma Multiforme:



Diseases related to Brain Glioblastoma Multiforme

Symptoms & Phenotypes for Brain Glioblastoma Multiforme

Symptoms:

12
  • seizure

UMLS symptoms related to Brain Glioblastoma Multiforme:


seizures; headache

Drugs & Therapeutics for Brain Glioblastoma Multiforme

Drugs for Brain Glioblastoma Multiforme (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Belinostat Approved, Investigational Phase 2 866323-14-0
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3 Antiviral Agents Phase 1, Phase 2
4 Anti-Infective Agents Phase 1, Phase 2
5 Gastrointestinal Agents Phase 1, Phase 2
6 Cathartics Phase 1, Phase 2
7 interferons Phase 1, Phase 2
8 Laxatives Phase 1, Phase 2
9 Poly ICLC Phase 1, Phase 2
10 Poly I-C Phase 1, Phase 2
11 Carboxymethylcellulose Sodium Phase 1, Phase 2
12 Immunologic Factors Phase 2
13 Vaccines Phase 1, Phase 2
14 Histone Deacetylase Inhibitors Phase 2
15
Dimethyl fumarate Approved, Investigational Phase 1 624-49-7 5271565 637568
16
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
17
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
18 Immunosuppressive Agents Phase 1
19 Dermatologic Agents Phase 1
20 Ferrosoferric Oxide
21 Pharmaceutical Solutions
22 Hematinics
23 Parenteral Nutrition Solutions
24 Fluorides Early Phase 1
25 Fluorodeoxyglucose F18 Early Phase 1
26 Radiopharmaceuticals Early Phase 1
27 Deoxyglucose Early Phase 1
28 Antimetabolites Early Phase 1

Interventional clinical trials:

(show all 18)
# Name Status NCT ID Phase Drugs
1 A Single-blind, Randomized, Clinical Trial Comparing the Efficacy of 6 Cycles Versus 12 Cycles Temozolomide Regimens in Adjuvant Treatment of Patients With Brain High Grade Glioma Unknown status NCT03633552 Phase 3 Temozolomide
2 Phase II Study of Antineoplastons A10 and AS2-1 In Patients With Glioblastoma Multiforme Completed NCT00003456 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
3 Effects of Deep Transcranial Magnetic Stimulation on the Permeability of the Blood-brain Barrier in Patients With Glioblastoma Multiforme: a Pilot Study Completed NCT02474966 Phase 2
4 A Phase 1/2 Study of SL-701, a Subcutaneously Injected Multivalent Glioma-Associated Antigen Vaccine, in Adult Patients With Recurrent Glioblastoma Multiforme (GBM) Completed NCT02078648 Phase 1, Phase 2 Bevacizumab
5 A Triple-blind Randomized Clinical Study of Vaccination With Dendritic Cells Loaded With Glioma Stem-like Cells Associated Antigens Against Brain Glioblastoma Multiform Recruiting NCT01567202 Phase 2 Chemotherapy;blank placebo
6 Adjuvant Dendritic-Cell Immunotherapy Plus Temozolomide Following Surgery and Chemoradiation in Patients With Newly Diagnosed Glioblastoma Recruiting NCT02649582 Phase 1, Phase 2
7 Avelumab in Patients With Newly Diagnosed Glioblastoma Multiforme Active, not recruiting NCT03047473 Phase 2
8 Ketogenic Diet Treatment Adjunctive to Radiation and Chemotherapy in Glioblastoma Multiforme: a Pilot Study Active, not recruiting NCT02302235 Phase 2
9 Quantitative Magnetic Resonance Spectroscopic Imaging (MRSI) to Predict Early Response to Standard Radiation Therapy (RT)/Temozolomide (TMZ) ± Belinostat Therapy in Newly-Diagnosed Glioblastomas (GBM) Active, not recruiting NCT02137759 Phase 2 Standard Temozolomide;Belinostat
10 Phase II Study of TRC102 in Combination With Temozolomide for Recurrent Glioblastoma Terminated NCT02395692 Phase 2 Methoxyamine;Temozolomide
11 Targeting Recurrent Glioblastoma With Anti-CD3 x Anti-EGFR Bispecific Antibody Armed T Cells: A Phase I/II Study Withdrawn NCT02521090 Phase 1, Phase 2
12 A Phase II, Multi-institutional Trial of NOVO-TTF-100A, BCNU and Bevacizumab for GBM in First Relapse Withdrawn NCT02348255 Phase 2 Carmustine
13 Phase I Trial of Dimethyl Fumarate, Temozolomide, and Radiation Therapy in Glioblastoma Multiforme Completed NCT02337426 Phase 1 Dimethyl Fumarate;Temozolomide
14 A Phase I, Multicentre Study to Assess the Safety, Tolerability, and Pharmacokinetics of Ascending Doses of AZD1390 in Combination With Radiation Therapy in Patients With Glioblastoma Multiforme and Brain Metastases From Solid Tumors. Recruiting NCT03423628 Phase 1 AZD1390
15 A Phase I Trial of IRS-1 HSV C134 Administered Intratumorally in Patients With Recurrent Malignant Glioma Active, not recruiting NCT03657576 Phase 1
16 Immunogene-modified Antigen-specific T (IgT) Cells for the Treatment of Glioblastoma Multiforme Enrolling by invitation NCT03170141 Phase 1
17 Early Assessment of Tumor Response to Therapy Using Ferumoxytol (Code 7228) as an MR Contrast Agent in Patients With Glioblastoma Multiforme (MedDRA Code 10018337) Completed NCT00660543 Gadolinium;Ferumoxytol Non-Stoichiometric Magnetite
18 Dual Time Point FDG PET Imaging Optimization for the Evaluation of Glioblastoma Recruiting NCT02885272 Early Phase 1

Search NIH Clinical Center for Brain Glioblastoma Multiforme

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Glioblastoma Multiforme cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Glioblastoma Multiforme:
Alescat, autologous lymphocyte-based therapy for the treatment of solid cancers

Genetic Tests for Brain Glioblastoma Multiforme

Anatomical Context for Brain Glioblastoma Multiforme

MalaCards organs/tissues related to Brain Glioblastoma Multiforme:

40
Brain, T Cells, Spinal Cord

Publications for Brain Glioblastoma Multiforme

Articles related to Brain Glioblastoma Multiforme:

(show all 21)
# Title Authors PMID Year
1
Glioblastoma evolving within 10 days following unremarkable computer tomography of the brain: a case report. 61
32253959 2020
2
Deciphering the Role of Glutamate Signaling in Glioblastoma Multiforme: Current Therapeutic Modalities and Future Directions. 61
32493186 2020
3
Tetrandrine inhibits human brain glioblastoma multiforme GBM 8401 cancer cell migration and invasion in vitro. 61
30549224 2019
4
Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo. 61
29972272 2018
5
Unilateral malignant optic glioma following glioblastoma multiforme in the young: a case report and literature review. 61
28284199 2017
6
Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. 61
26678675 2017
7
PEITC induces apoptosis of Human Brain Glioblastoma GBM8401 Cells through the extrinsic- and intrinsic -signaling pathways. 61
25582659 2015
8
Treatment of brain glioblastoma multiforme with pcDNA3.1-Egr. 1p-p16 combined with gamma knife radiation: an experimental study on nude mice. 61
24262451 2013
9
Differentiation between brain glioblastoma multiforme and solitary metastasis: qualitative and quantitative analysis based on routine MR imaging. 61
22743640 2012
10
Focused ultrasound and interleukin-4 receptor-targeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme. 61
22405901 2012
11
Pharmacokinetic analysis of 111 in-labeled liposomal Doxorubicin in murine glioblastoma after blood-brain barrier disruption by focused ultrasound. 61
23029030 2012
12
Curcuminoids suppress the growth and induce apoptosis through caspase-3-dependent pathways in glioblastoma multiforme (GBM) 8401 cells. 61
20822178 2010
13
Metastatic gliosarcoma mass extension to a donor fascia lata graft harvest site by tumor cell contamination. 61
20934163 2010
14
Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metalloproteinase-9. 61
19787217 2009
15
Brain cancer stem cells. 61
19784875 2009
16
Spinal cord and brain glioblastoma multiforme without previous craniotomy. 61
18518686 2008
17
APRIL is increased in serum of patients with brain glioblastoma multiforme. 61
17353162 2006
18
Extremely rare glioblastoma multiforme of the conus medullaris with holocord and brain stem metastases, leading to cranial nerve deficit and respiratory failure: a case report and review of the literature. 61
15936395 2005
19
Concentration of elements in human brain: glioblastoma multiforme. 61
8272844 1993
20
Establishment and characterization of a malignant glioma cell line, GBM8401/TSGH,NDMC. 61
2839737 1988
21
Preparatory clinical studies of Pi-mesons at TRIUMF. 61
3003786 1985

Variations for Brain Glioblastoma Multiforme

Expression for Brain Glioblastoma Multiforme

Search GEO for disease gene expression data for Brain Glioblastoma Multiforme.

Pathways for Brain Glioblastoma Multiforme

Pathways related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.65 MMP9 MMP7 CASP3
2 11.41 TNFSF13 MMP9 CASP3
3 10.62 MMP9 MMP7 CASP3
4 10.19 MMP9 MMP7

GO Terms for Brain Glioblastoma Multiforme

Cellular components related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mitochondrial small ribosomal subunit GO:0005763 8.96 MRPS34 MRPS2
2 ribosome GO:0005840 8.92 RPL23 MRPS34 MRPS2 MRPL23

Biological processes related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane protein intracellular domain proteolysis GO:0031293 9.37 RHBDD1 MMP7
2 mitochondrial translational termination GO:0070126 9.33 MRPS34 MRPS2 MRPL23
3 response to X-ray GO:0010165 9.32 XRRA1 CASP3
4 stabilization of membrane potential GO:0030322 9.26 KCNK15 KCNK12
5 mitochondrial translational elongation GO:0070125 9.13 MRPS34 MRPS2 MRPL23
6 mitochondrial translation GO:0032543 8.8 MRPS34 MRPS2 MRPL23

Molecular functions related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 serine-type endopeptidase activity GO:0004252 9.43 RHBDD1 MMP9 MMP7
2 potassium ion leak channel activity GO:0022841 9.16 KCNK15 KCNK12
3 endopeptidase activity GO:0004175 9.13 RHBDD1 MMP9 MMP7
4 structural constituent of ribosome GO:0003735 8.92 RPL23 MRPS34 MRPS2 MRPL23

Sources for Brain Glioblastoma Multiforme

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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