MCID: BRN005
MIFTS: 35

Brain Glioblastoma Multiforme

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Glioblastoma Multiforme

MalaCards integrated aliases for Brain Glioblastoma Multiforme:

Name: Brain Glioblastoma Multiforme 38 12 15
Glioblastoma Multiforme of Brain 12 73
Brain Glioblastoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3073
NCIt 50 C4642
SNOMED-CT 68 276828006
UMLS 73 C0349543

Summaries for Brain Glioblastoma Multiforme

MalaCards based summary : Brain Glioblastoma Multiforme, also known as glioblastoma multiforme of brain, is related to focal myositis and spastic entropion, and has symptoms including headache and seizures. An important gene associated with Brain Glioblastoma Multiforme is MMP7 (Matrix Metallopeptidase 7), and among its related pathways/superpathways are Colorectal Cancer Metastasis and Validated targets of C-MYC transcriptional activation. The drugs Temozolomide and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and spinal cord, and related phenotype is neoplasm.

Related Diseases for Brain Glioblastoma Multiforme

Graphical network of the top 20 diseases related to Brain Glioblastoma Multiforme:



Diseases related to Brain Glioblastoma Multiforme

Symptoms & Phenotypes for Brain Glioblastoma Multiforme

UMLS symptoms related to Brain Glioblastoma Multiforme:


headache, seizures

MGI Mouse Phenotypes related to Brain Glioblastoma Multiforme:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 MMP7 MMP9 TP53 TRAP1

Drugs & Therapeutics for Brain Glioblastoma Multiforme

Drugs for Brain Glioblastoma Multiforme (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 2,Phase 1,Not Applicable 85622-93-1 5394
2
Bevacizumab Approved, Investigational Phase 1, Phase 2,Phase 2 216974-75-3
3
Dacarbazine Approved, Investigational Phase 1, Phase 2,Phase 2 4342-03-4 5351166
4
Belinostat Approved, Investigational Phase 2 866323-14-0
5
Cyclophosphamide Approved, Investigational Phase 1, Phase 2 50-18-0, 6055-19-2 2907
6
Fludarabine Approved Phase 1, Phase 2,Phase 2 21679-14-1, 75607-67-9 30751
7 Vaccines Phase 2,Phase 1
8 Angiogenesis Inhibitors Phase 1, Phase 2,Phase 2
9 Angiogenesis Modulating Agents Phase 1, Phase 2,Phase 2
10 Anti-Infective Agents Phase 1, Phase 2
11 Antiviral Agents Phase 1, Phase 2
12 Carboxymethylcellulose Sodium Phase 1, Phase 2
13 Cathartics Phase 1, Phase 2
14 Gastrointestinal Agents Phase 1, Phase 2
15 Interferon Inducers Phase 1, Phase 2
16 interferons Phase 1, Phase 2
17 Laxatives Phase 1, Phase 2
18 Poly I-C Phase 1, Phase 2
19 Poly ICLC Phase 1, Phase 2
20 Alkylating Agents Phase 1, Phase 2,Phase 2,Not Applicable
21 Antineoplastic Agents, Alkylating Phase 1, Phase 2,Phase 2,Not Applicable
22 Antibodies Phase 2,Phase 1
23 Antibodies, Monoclonal Phase 2
24 Immunoglobulins Phase 2,Phase 1
25 Histone Deacetylase Inhibitors Phase 2
26
Dimethyl fumarate Approved, Investigational Phase 1 624-49-7 5271565 637568
27 Dermatologic Agents Phase 1
28 Immunosuppressive Agents Phase 1
29 Ferrosoferric Oxide Not Applicable
30 Hematinics Not Applicable
31 Parenteral Nutrition Solutions Not Applicable
32 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 Study of DC Vaccination Against Glioblastoma Unknown status NCT01567202 Phase 2 Chemotherapy;blank placebo
2 Effect of Deep TMS on the Permeability of the BBB in Patients With Glioblastoma Multiforme: a Pilot Study Completed NCT02474966 Phase 2
3 Antineoplaston Therapy in Treating Patients With Newly-diagnosed Glioblastoma Multiforme Completed NCT00003456 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
4 Antineoplaston Therapy in Treating Adults With Residual/Recurrent/Progressive Glioblastoma Multiforme Completed NCT00003474 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
5 Safety and Efficacy Study of SL-701, a Glioma-Associated Antigen Vaccine To Treat Recurrent Glioblastoma Multiforme Completed NCT02078648 Phase 1, Phase 2 Bevacizumab
6 Avelumab in Patients With Newly Diagnosed Glioblastoma Multiforme Recruiting NCT03047473 Phase 2
7 Adjuvant Dendritic Cell-immunotherapy Plus Temozolomide in Glioblastoma Patients Recruiting NCT02649582 Phase 1, Phase 2
8 Ketogenic Diet Treatment Adjunctive to Radiation and Chemotherapy in Glioblastoma Multiforme: a Pilot Study Recruiting NCT02302235 Phase 2
9 MRSI to Predict Response to RT/TMZ ± Belinostat in GBM Recruiting NCT02137759 Phase 2 Standard Temozolomide;Belinostat
10 Methoxyamine and Temozolomide in Treating Patients With Recurrent Glioblastoma Active, not recruiting NCT02395692 Phase 2 Methoxyamine;Temozolomide
11 4SCAR-IgT Against Glioblastoma Multiform Enrolling by invitation NCT03170141 Phase 1, Phase 2
12 NovoTTF-100A With Bevacizumab and Carmustine in Treating Patients With Glioblastoma Multiforme in First Relapse Withdrawn NCT02348255 Phase 2 Carmustine
13 EGFRBi-Armed Autologous T Cells in Treating Patients With Recurrent or Refractory Glioblastoma Withdrawn NCT02521090 Phase 1, Phase 2
14 Dimethyl Fumarate, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Active, not recruiting NCT02337426 Phase 1 Dimethyl Fumarate;Temozolomide
15 MRI Study With Ferumoxytol in Assessing Early Response in Patients With Glioblastoma Multiforme Receiving Temozolomide and Radiation Therapy Completed NCT00660543 Not Applicable Gadolinium;Ferumoxytol Non-Stoichiometric Magnetite
16 Steady State Blood Volume Maps Using Ferumoxytol Non-stoichiometric Magnetite MRI in Imaging Patients With Glioblastoma Recruiting NCT02359097 Not Applicable Ferumoxytol;Gadoteridol
17 Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer Recruiting NCT03154190 Not Applicable

Search NIH Clinical Center for Brain Glioblastoma Multiforme

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Glioblastoma Multiforme cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Glioblastoma Multiforme:
Alescat, autologous lymphocyte-based therapy for the treatment of solid cancers

Genetic Tests for Brain Glioblastoma Multiforme

Anatomical Context for Brain Glioblastoma Multiforme

MalaCards organs/tissues related to Brain Glioblastoma Multiforme:

41
Brain, T Cells, Spinal Cord

Publications for Brain Glioblastoma Multiforme

Articles related to Brain Glioblastoma Multiforme:

# Title Authors Year
1
Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo. ( 29972272 )
2018
2
Treatment of brain glioblastoma multiforme with pcDNA3.1-Egr. 1p-p16 combined with gamma knife radiation: an experimental study on nude mice. ( 24262451 )
2013
3
Differentiation between brain glioblastoma multiforme and solitary metastasis: qualitative and quantitative analysis based on routine MR imaging. ( 22743640 )
2012
4
Danthron induced apoptosis through mitochondria- and caspase-3-dependent pathways in human brain glioblastoma multiforms GBM 8401 cells. ( 19784869 )
2010
5
Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metalloproteinase-9. ( 19787217 )
2009
6
Spinal cord and brain glioblastoma multiforme without previous craniotomy. ( 18518686 )
2008
7
APRIL is increased in serum of patients with brain glioblastoma multiforme. ( 17353162 )
2006
8
Concentration of elements in human brain: glioblastoma multiforme. ( 8272844 )
1993

Variations for Brain Glioblastoma Multiforme

Expression for Brain Glioblastoma Multiforme

Search GEO for disease gene expression data for Brain Glioblastoma Multiforme.

Pathways for Brain Glioblastoma Multiforme

Pathways related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.55 MMP7 MMP9 TP53
2 11.34 MMP9 TP53
3 11.27 MMP9 TP53
4 11.19 MMP7 MMP9
5
Show member pathways
11.14 MMP7 TP53
6 11.04 MMP7 MMP9
7 10.88 MMP9 TNFSF13 TP53
8 10.19 MMP7 MMP9

GO Terms for Brain Glioblastoma Multiforme

Biological processes related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 9.16 MMP7 MMP9
2 collagen catabolic process GO:0030574 8.96 MMP7 MMP9
3 positive regulation of release of cytochrome c from mitochondria GO:0090200 8.62 MMP9 TP53

Molecular functions related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 TNFSF13 TRAP1

Sources for Brain Glioblastoma Multiforme

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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