MCID: BRN005
MIFTS: 36

Brain Glioblastoma Multiforme

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Glioblastoma Multiforme

MalaCards integrated aliases for Brain Glioblastoma Multiforme:

Name: Brain Glioblastoma Multiforme 39 12 15
Glioblastoma Multiforme of Brain 12 74
Brain Glioblastoma 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:3073
NCIt 51 C4642
UMLS 74 C0349543

Summaries for Brain Glioblastoma Multiforme

Disease Ontology : 12 A brain glioma that has material basis in abnormally proliferating cells derives from glial cells, has symptom seizure, headaches, nausea and vomiting, memory loss, changes to personality, mood or concentration; and localized neurological problems.

MalaCards based summary : Brain Glioblastoma Multiforme, also known as glioblastoma multiforme of brain, is related to glioblastoma and glioma susceptibility 1, and has symptoms including seizure, seizures and headache. An important gene associated with Brain Glioblastoma Multiforme is MMP7 (Matrix Metallopeptidase 7), and among its related pathways/superpathways are Angiogenesis (CST) and Colorectal Cancer Metastasis. The drugs Temozolomide and Antineoplastic Agents, Alkylating have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and spinal cord.

Related Diseases for Brain Glioblastoma Multiforme

Diseases related to Brain Glioblastoma Multiforme via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 20, show less)
# Related Disease Score Top Affiliating Genes
1 glioblastoma 10.5
2 glioma susceptibility 1 10.5
3 glioblastoma multiforme 10.5
4 focal myositis 10.2 MMP7 MMP9
5 spastic entropion 10.2 MMP7 MMP9
6 senile ectropion 10.1 MMP7 MMP9
7 internal hemorrhoid 10.1 MMP7 MMP9
8 light chain deposition disease 10.1 MMP7 MMP9
9 pediatric multiple sclerosis 10.1 MMP7 MMP9
10 villonodular synovitis 10.0 MMP9 SOS1
11 adult astrocytic tumour 10.0 MMP7 MMP9
12 astrocytoma 10.0
13 varicose veins 10.0 MMP7 MMP9
14 gastrointestinal system cancer 9.9 MMP7 MMP9
15 lung cancer susceptibility 3 9.7
16 melanoma 9.7
17 placental choriocarcinoma 9.7
18 adenocarcinoma 9.7
19 choriocarcinoma 9.7
20 acute cholinergic dysautonomia 9.7

Graphical network of the top 20 diseases related to Brain Glioblastoma Multiforme:



Diseases related to Brain Glioblastoma Multiforme

Symptoms & Phenotypes for Brain Glioblastoma Multiforme

Symptoms:

12 (showing 1, show less)
  • seizure

UMLS symptoms related to Brain Glioblastoma Multiforme:


seizures, headache

Drugs & Therapeutics for Brain Glioblastoma Multiforme

Drugs for Brain Glioblastoma Multiforme (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 36, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 3,Phase 1,Phase 2,Not Applicable 85622-93-1 5394
2 Antineoplastic Agents, Alkylating Phase 3,Phase 1,Phase 2,Not Applicable
3 Alkylating Agents Phase 3,Phase 1,Phase 2,Not Applicable
4
Bevacizumab Approved, Investigational Phase 1, Phase 2,Phase 2 216974-75-3
5
Belinostat Approved, Investigational Phase 2 866323-14-0
6
Pembrolizumab Approved Phase 1, Phase 2 1374853-91-4
7 Poly ICLC Phase 1, Phase 2,Phase 2
8 Cathartics Phase 1, Phase 2,Phase 2
9 Gastrointestinal Agents Phase 1, Phase 2,Phase 2
10 Immunologic Factors Phase 1, Phase 2,Phase 2
11 Laxatives Phase 1, Phase 2,Phase 2
12 Antiviral Agents Phase 1, Phase 2,Phase 2
13 Angiogenesis Modulating Agents Phase 1, Phase 2,Phase 2
14 Interferon Inducers Phase 1, Phase 2,Phase 2
15 Angiogenesis Inhibitors Phase 1, Phase 2,Phase 2
16 interferons Phase 1, Phase 2,Phase 2
17 Antineoplastic Agents, Immunological Phase 1, Phase 2,Phase 2
18 Carboxymethylcellulose Sodium Phase 1, Phase 2,Phase 2
19 Poly I-C Phase 1, Phase 2,Phase 2
20 Vaccines Phase 1, Phase 2,Phase 2
21 Anti-Infective Agents Phase 1, Phase 2,Phase 2
22 Antibodies, Monoclonal Phase 2
23 Immunoglobulins Phase 2,Phase 1
24 Antibodies Phase 2,Phase 1
25 Histone Deacetylase Inhibitors Phase 2
26
Dimethyl fumarate Approved, Investigational Phase 1 624-49-7 5271565 637568
27
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
28
Fludarabine Approved Phase 1 75607-67-9, 21679-14-1 30751
29 Dermatologic Agents Phase 1
30 Immunosuppressive Agents Phase 1
31 Parenteral Nutrition Solutions Not Applicable
32 Hematinics Not Applicable
33 Ferrosoferric Oxide Not Applicable
34 Pharmaceutical Solutions Not Applicable
35 Anesthetics Not Applicable
36 Central Nervous System Depressants Not Applicable

Interventional clinical trials:

(showing 22, show less)
# Name Status NCT ID Phase Drugs
1 Efficacy of Two Temozolomide Regimens in Adjuvant Treatment of Patients With Brain High Grade Glioma Recruiting NCT03633552 Phase 3 Temozolomide
2 Effect of Deep TMS on the Permeability of the BBB in Patients With Glioblastoma Multiforme: a Pilot Study Completed NCT02474966 Phase 2
3 Antineoplaston Therapy in Treating Patients With Newly-diagnosed Glioblastoma Multiforme Completed NCT00003456 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
4 Antineoplaston Therapy in Treating Adults With Residual/Recurrent/Progressive Glioblastoma Multiforme Completed NCT00003474 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
5 Safety and Efficacy Study of SL-701, a Glioma-Associated Antigen Vaccine To Treat Recurrent Glioblastoma Multiforme Completed NCT02078648 Phase 1, Phase 2 Bevacizumab
6 Avelumab in Patients With Newly Diagnosed Glioblastoma Multiforme Recruiting NCT03047473 Phase 2
7 Adjuvant Dendritic Cell-immunotherapy Plus Temozolomide in Glioblastoma Patients Recruiting NCT02649582 Phase 1, Phase 2
8 Ketogenic Diet Treatment Adjunctive to Radiation and Chemotherapy in Glioblastoma Multiforme: a Pilot Study Recruiting NCT02302235 Phase 2
9 MRSI to Predict Response to RT/TMZ ± Belinostat in GBM Recruiting NCT02137759 Phase 2 Standard Temozolomide;Belinostat
10 Study of DC Vaccination Against Glioblastoma Recruiting NCT01567202 Phase 2 Chemotherapy;blank placebo
11 Pembrolizumab in Association With the IMA950/Poly-ICLC for Relapsing Glioblastoma Recruiting NCT03665545 Phase 1, Phase 2 IMA950/Poly-ICLC;IMA950/Poly-ICLC and pembrolizumab
12 Methoxyamine and Temozolomide in Treating Patients With Recurrent Glioblastoma Terminated NCT02395692 Phase 2 Methoxyamine;Temozolomide
13 NovoTTF-100A With Bevacizumab and Carmustine in Treating Patients With Glioblastoma Multiforme in First Relapse Withdrawn NCT02348255 Phase 2 Carmustine
14 EGFRBi-Armed Autologous T Cells in Treating Patients With Recurrent or Refractory Glioblastoma Withdrawn NCT02521090 Phase 1, Phase 2
15 Dimethyl Fumarate, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Completed NCT02337426 Phase 1 Dimethyl Fumarate;Temozolomide
16 Immunogene-modified T (IgT) Cells Against Glioblastoma Multiforme Enrolling by invitation NCT03170141 Phase 1
17 Trial of C134 in Patients With Recurrent GBM Not yet recruiting NCT03657576 Phase 1
18 MRI Study With Ferumoxytol in Assessing Early Response in Patients With Glioblastoma Multiforme Receiving Temozolomide and Radiation Therapy Completed NCT00660543 Not Applicable Gadolinium;Ferumoxytol Non-Stoichiometric Magnetite
19 Steady State Blood Volume Maps Using Ferumoxytol Non-stoichiometric Magnetite MRI in Imaging Patients With Glioblastoma Recruiting NCT02359097 Not Applicable Ferumoxytol;Gadoteridol
20 Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer Recruiting NCT03154190 Not Applicable
21 The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients. Recruiting NCT03861299 Not Applicable
22 Deciphering Mechanisms Underlying Cancer Immunogenicity Not yet recruiting NCT03958240 Not Applicable

Search NIH Clinical Center for Brain Glioblastoma Multiforme

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Glioblastoma Multiforme cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Glioblastoma Multiforme:
Alescat, autologous lymphocyte-based therapy for the treatment of solid cancers

Genetic Tests for Brain Glioblastoma Multiforme

Anatomical Context for Brain Glioblastoma Multiforme

MalaCards organs/tissues related to Brain Glioblastoma Multiforme:

42
Brain, T Cells, Spinal Cord

Publications for Brain Glioblastoma Multiforme

Articles related to Brain Glioblastoma Multiforme:

(showing 8, show less)
# Title Authors Year
1
Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo. ( 29972272 )
2018
2
Tetrandrine inhibits human brain glioblastoma multiforme GBM 8401 cancer cell migration and invasion in vitro. ( 30549224 )
2018
3
Treatment of brain glioblastoma multiforme with pcDNA3.1-Egr. 1p-p16 combined with gamma knife radiation: an experimental study on nude mice. ( 24262451 )
2013
4
Differentiation between brain glioblastoma multiforme and solitary metastasis: qualitative and quantitative analysis based on routine MR imaging. ( 22743640 )
2012
5
Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metalloproteinase-9. ( 19787217 )
2009
6
Spinal cord and brain glioblastoma multiforme without previous craniotomy. ( 18518686 )
2008
7
APRIL is increased in serum of patients with brain glioblastoma multiforme. ( 17353162 )
2006
8
Concentration of elements in human brain: glioblastoma multiforme. ( 8272844 )
1993

Variations for Brain Glioblastoma Multiforme

Expression for Brain Glioblastoma Multiforme

Search GEO for disease gene expression data for Brain Glioblastoma Multiforme.

Pathways for Brain Glioblastoma Multiforme

Pathways related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(showing 8, show less)
# Super pathways Score Top Affiliating Genes
1 11.38 MMP7 MMP9
2 11.35 MMP7 MMP9 SOS1
3 11.26 SOS1 TNPO1
4 11.19 MMP7 MMP9
5 11.11 MMP7 MMP9
6 10.93 MMP9 SOS1
7 10.57 MMP9 SOS1
8 9.85 MMP7 MMP9

GO Terms for Brain Glioblastoma Multiforme

Cellular components related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 8.8 MRPL12 MRPS34 TRAP1

Biological processes related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 mitochondrial translational elongation GO:0070125 9.37 MRPL12 MRPS34
2 mitochondrial translational termination GO:0070126 9.32 MRPL12 MRPS34
3 regulation of mRNA stability GO:0043488 9.26 TNFSF13 TNPO1
4 extracellular matrix disassembly GO:0022617 9.16 MMP7 MMP9
5 collagen catabolic process GO:0030574 8.96 MMP7 MMP9
6 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 8.62 MMP9 SOS1

Molecular functions related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 TNFSF13 TRAP1

Sources for Brain Glioblastoma Multiforme

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....