MCID: BRN005
MIFTS: 34

Brain Glioblastoma Multiforme

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Glioblastoma Multiforme

MalaCards integrated aliases for Brain Glioblastoma Multiforme:

Name: Brain Glioblastoma Multiforme 12 15 38
Glioblastoma Multiforme of Brain 12 72
Brain Glioblastoma 12 17

Classifications:



External Ids:

Disease Ontology 12 DOID:3073
NCIt 50 C4642
UMLS 72 C0349543

Summaries for Brain Glioblastoma Multiforme

Disease Ontology : 12 A brain glioma that has material basis in abnormally proliferating cells derives from glial cells, has symptom seizure, headaches, nausea and vomiting, memory loss, changes to personality, mood or concentration; and localized neurological problems.

MalaCards based summary : Brain Glioblastoma Multiforme, also known as glioblastoma multiforme of brain, is related to glioblastoma multiforme and glioblastoma, and has symptoms including seizure, seizures and headache. An important gene associated with Brain Glioblastoma Multiforme is MMP7 (Matrix Metallopeptidase 7), and among its related pathways/superpathways are Angiogenesis (CST) and Colorectal Cancer Metastasis. The drugs Belinostat and Temozolomide have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and spinal cord.

Related Diseases for Brain Glioblastoma Multiforme

Diseases related to Brain Glioblastoma Multiforme via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 24, show less)
# Related Disease Score Top Affiliating Genes
1 glioblastoma multiforme 10.5
2 glioblastoma 10.5
3 focal myositis 10.3 MMP9 MMP7
4 spastic entropion 10.3 MMP9 MMP7
5 senile ectropion 10.2 MMP9 MMP7
6 internal hemorrhoid 10.2 MMP9 MMP7
7 light chain deposition disease 10.2 MMP9 MMP7
8 pediatric multiple sclerosis 10.1 MMP9 MMP7
9 glioma 10.1
10 villonodular synovitis 10.1 SOS1 MMP9
11 adult astrocytic tumour 10.1 MMP9 MMP7
12 malignant glioma 10.1
13 ataxia-telangiectasia 10.0
14 ataxia and polyneuropathy, adult-onset 10.0
15 telangiectasis 10.0
16 brain cancer 10.0
17 astrocytoma 10.0
18 glial tumor 10.0
19 varicose veins 10.0 MMP9 MMP7
20 gastrointestinal system cancer 9.8 MMP9 MMP7
21 lung cancer susceptibility 3 9.8
22 melanoma 9.8
23 placental choriocarcinoma 9.8
24 choriocarcinoma 9.8

Graphical network of the top 20 diseases related to Brain Glioblastoma Multiforme:



Diseases related to Brain Glioblastoma Multiforme

Symptoms & Phenotypes for Brain Glioblastoma Multiforme

Symptoms:

12 (showing 1, show less)
  • seizure

UMLS symptoms related to Brain Glioblastoma Multiforme:


seizures, headache

Drugs & Therapeutics for Brain Glioblastoma Multiforme

Drugs for Brain Glioblastoma Multiforme (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 33, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Belinostat Approved, Investigational Phase 2 866323-14-0
2
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
3
Aminolevulinic acid Approved Phase 2 106-60-5 137
4 Gastrointestinal Agents Phase 1, Phase 2
5 Cathartics Phase 1, Phase 2
6 Carboxymethylcellulose Sodium Phase 1, Phase 2
7 Anti-Infective Agents Phase 1, Phase 2
8 Laxatives Phase 1, Phase 2
9 Interferon Inducers Phase 1, Phase 2
10 Poly I-C Phase 1, Phase 2
11 interferons Phase 1, Phase 2
12 Poly ICLC Phase 1, Phase 2
13 Antiviral Agents Phase 1, Phase 2
14 Immunologic Factors Phase 1, Phase 2
15 Vaccines Phase 2
16 Antibodies, Monoclonal Phase 2
17 Histone Deacetylase Inhibitors Phase 2
18 Dermatologic Agents Phase 2
19 Photosensitizing Agents Phase 2
20
Dimethyl fumarate Approved, Investigational Phase 1 624-49-7 5271565 637568
21
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
22
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
23 Immunosuppressive Agents Phase 1
24 Fluorodeoxyglucose F18 Early Phase 1
25 Radiopharmaceuticals Early Phase 1
26 Fluorides Early Phase 1
27 Deoxyglucose Early Phase 1
28 Cariostatic Agents
29 Protective Agents
30 Parenteral Nutrition Solutions
31 Pharmaceutical Solutions
32 Ferrosoferric Oxide
33 Hematinics

Interventional clinical trials:

(showing 24, show less)
# Name Status NCT ID Phase Drugs
1 A Single-blind, Randomized, Clinical Trial Comparing the Efficacy of 6 Cycles Versus 12 Cycles Temozolomide Regimens in Adjuvant Treatment of Patients With Brain High Grade Glioma Recruiting NCT03633552 Phase 3 Temozolomide
2 Phase II Study of Antineoplastons A10 and AS2-1 In Patients With Glioblastoma Multiforme Completed NCT00003456 Phase 2 Antineoplaston therapy (Atengenal + Astugenal)
3 Effects of Deep Transcranial Magnetic Stimulation on the Permeability of the Blood-brain Barrier in Patients With Glioblastoma Multiforme: a Pilot Study Completed NCT02474966 Phase 2
4 A Phase 2 Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Primary Glial Neoplasms of the Brain. Completed NCT00961090 Phase 2 Aminolevulinic Acid
5 A Phase 1/2 Study of SL-701, a Subcutaneously Injected Multivalent Glioma-Associated Antigen Vaccine, in Adult Patients With Recurrent Glioblastoma Multiforme (GBM) Completed NCT02078648 Phase 1, Phase 2 Bevacizumab
6 Adjuvant Dendritic-Cell Immunotherapy Plus Temozolomide Following Surgery and Chemoradiation in Patients With Newly Diagnosed Glioblastoma Recruiting NCT02649582 Phase 1, Phase 2
7 Avelumab in Patients With Newly Diagnosed Glioblastoma Multiforme Recruiting NCT03047473 Phase 2
8 A Triple-blind Randomized Clinical Study of Vaccination With Dendritic Cells Loaded With Glioma Stem-like Cells Associated Antigens Against Brain Glioblastoma Multiform Recruiting NCT01567202 Phase 2 Chemotherapy;blank placebo
9 Quantitative Magnetic Resonance Spectroscopic Imaging (MRSI) to Predict Early Response to Standard Radiation Therapy (RT)/Temozolomide (TMZ) ± Belinostat Therapy in Newly-Diagnosed Glioblastomas (GBM) Active, not recruiting NCT02137759 Phase 2 Standard Temozolomide;Belinostat
10 Ketogenic Diet Treatment Adjunctive to Radiation and Chemotherapy in Glioblastoma Multiforme: a Pilot Study Active, not recruiting NCT02302235 Phase 2
11 A Phase 2 Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain Terminated NCT01351519 Phase 2 Aminolevulinic Acid
12 Phase II Study of TRC102 in Combination With Temozolomide for Recurrent Glioblastoma Terminated NCT02395692 Phase 2 Methoxyamine;Temozolomide
13 A Phase II, Multi-institutional Trial of NOVO-TTF-100A, BCNU and Bevacizumab for GBM in First Relapse Withdrawn NCT02348255 Phase 2 Carmustine
14 Targeting Recurrent Glioblastoma With Anti-CD3 x Anti-EGFR Bispecific Antibody Armed T Cells: A Phase I/II Study Withdrawn NCT02521090 Phase 1, Phase 2
15 Phase I Trial of Dimethyl Fumarate, Temozolomide, and Radiation Therapy in Glioblastoma Multiforme Completed NCT02337426 Phase 1 Dimethyl Fumarate;Temozolomide
16 A Phase I Trial of Hypofraction Radiotherapy + Temozolomide in the Treatment of Patients With Glioblastoma Multiforme and Anaplastic Astrocytoma of the Brain Completed NCT00841555 Phase 1 temozolomide
17 Immunogene-modified Antigen-specific T (IgT) Cells for the Treatment of Glioblastoma Multiforme Enrolling by invitation NCT03170141 Phase 1
18 A Phase I Trial of IRS-1 HSV C134 Administered Intratumorally in Patients With Recurrent Malignant Glioma Not yet recruiting NCT03657576 Phase 1
19 A Phase 1 Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain Terminated NCT01148966 Phase 1 aminolevulinic acid
20 Early Assessment of Tumor Response to Therapy Using Ferumoxytol (Code 7228) as an MR Contrast Agent in Patients With Glioblastoma Multiforme (MedDRA Code 10018337) Completed NCT00660543 Gadolinium;Ferumoxytol Non-Stoichiometric Magnetite
21 Dual Time Point FDG PET Imaging Optimization for the Evaluation of Glioblastoma Recruiting NCT02885272 Early Phase 1
22 Multi-parametric MRI/Fluorine-18 Fluciclovine PET-CT in Glioblastoma Recruiting NCT03409549
23 High Resolution Steady State Blood Volume Maps in Glioblastoma Using MRI ? A Multicenter Study Recruiting NCT02359097 Ferumoxytol;Gadoteridol
24 Deciphering Mechanisms Underlying Cancer Immunogenicity Not yet recruiting NCT03958240

Search NIH Clinical Center for Brain Glioblastoma Multiforme

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Glioblastoma Multiforme cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Glioblastoma Multiforme:
Alescat, autologous lymphocyte-based therapy for the treatment of solid cancers

Genetic Tests for Brain Glioblastoma Multiforme

Anatomical Context for Brain Glioblastoma Multiforme

MalaCards organs/tissues related to Brain Glioblastoma Multiforme:

41
Brain, T Cells, Spinal Cord

Publications for Brain Glioblastoma Multiforme

Articles related to Brain Glioblastoma Multiforme:

(showing 19, show less)
# Title Authors PMID Year
1
Tetrandrine inhibits human brain glioblastoma multiforme GBM 8401 cancer cell migration and invasion in vitro. 38
30549224 2019
2
Benzyl isothiocyanate inhibits human brain glioblastoma multiforme GBM 8401 cell xenograft tumor in nude mice in vivo. 38
29972272 2018
3
Unilateral malignant optic glioma following glioblastoma multiforme in the young: a case report and literature review. 38
28284199 2017
4
Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. 38
26678675 2017
5
PEITC induces apoptosis of Human Brain Glioblastoma GBM8401 Cells through the extrinsic- and intrinsic -signaling pathways. 38
25582659 2015
6
Treatment of brain glioblastoma multiforme with pcDNA3.1-Egr. 1p-p16 combined with gamma knife radiation: an experimental study on nude mice. 38
24262451 2013
7
Differentiation between brain glioblastoma multiforme and solitary metastasis: qualitative and quantitative analysis based on routine MR imaging. 38
22743640 2012
8
Focused ultrasound and interleukin-4 receptor-targeted liposomal doxorubicin for enhanced targeted drug delivery and antitumor effect in glioblastoma multiforme. 38
22405901 2012
9
Pharmacokinetic analysis of 111 in-labeled liposomal Doxorubicin in murine glioblastoma after blood-brain barrier disruption by focused ultrasound. 38
23029030 2012
10
Curcuminoids suppress the growth and induce apoptosis through caspase-3-dependent pathways in glioblastoma multiforme (GBM) 8401 cells. 38
20822178 2010
11
Metastatic gliosarcoma mass extension to a donor fascia lata graft harvest site by tumor cell contamination. 38
20934163 2010
12
Danthron inhibits the migration and invasion of human brain glioblastoma multiforme cells through the inhibition of mRNA expression of focal adhesion kinase, Rho kinases-1 and metalloproteinase-9. 38
19787217 2009
13
Brain cancer stem cells. 38
19784875 2009
14
Spinal cord and brain glioblastoma multiforme without previous craniotomy. 38
18518686 2008
15
APRIL is increased in serum of patients with brain glioblastoma multiforme. 38
17353162 2006
16
Extremely rare glioblastoma multiforme of the conus medullaris with holocord and brain stem metastases, leading to cranial nerve deficit and respiratory failure: a case report and review of the literature. 38
15936395 2005
17
Concentration of elements in human brain: glioblastoma multiforme. 38
8272844 1993
18
Establishment and characterization of a malignant glioma cell line, GBM8401/TSGH,NDMC. 38
2839737 1988
19
Preparatory clinical studies of Pi-mesons at TRIUMF. 38
3003786 1985

Variations for Brain Glioblastoma Multiforme

Expression for Brain Glioblastoma Multiforme

Search GEO for disease gene expression data for Brain Glioblastoma Multiforme.

Pathways for Brain Glioblastoma Multiforme

Pathways related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(showing 8, show less)
# Super pathways Score Top Affiliating Genes
1 11.38 MMP9 MMP7
2 11.35 SOS1 MMP9 MMP7
3 11.26 TNPO1 SOS1
4 11.19 MMP9 MMP7
5 11.11 MMP9 MMP7
6 10.93 SOS1 MMP9
7 10.57 SOS1 MMP9
8 9.85 MMP9 MMP7

GO Terms for Brain Glioblastoma Multiforme

Cellular components related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 mitochondrial inner membrane GO:0005743 8.8 TRAP1 MRPS34 MRPL12

Biological processes related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(showing 6, show less)
# Name GO ID Score Top Affiliating Genes
1 mitochondrial translational termination GO:0070126 9.37 MRPS34 MRPL12
2 mitochondrial translational elongation GO:0070125 9.32 MRPS34 MRPL12
3 regulation of mRNA stability GO:0043488 9.26 TNPO1 TNFSF13
4 extracellular matrix disassembly GO:0022617 9.16 MMP9 MMP7
5 collagen catabolic process GO:0030574 8.96 MMP9 MMP7
6 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 8.62 SOS1 MMP9

Molecular functions related to Brain Glioblastoma Multiforme according to GeneCards Suite gene sharing:

(showing 1, show less)
# Name GO ID Score Top Affiliating Genes
1 tumor necrosis factor receptor binding GO:0005164 8.62 TRAP1 TNFSF13

Sources for Brain Glioblastoma Multiforme

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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