MCID: BRN032
MIFTS: 43

Brain Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Glioma

MalaCards integrated aliases for Brain Glioma:

Name: Brain Glioma 12 15
Intracranial Glioma 71
Lower Grade Glioma 12
Glioma of Brain 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0060108
UMLS 71 C3665419

Summaries for Brain Glioma

Disease Ontology : 12 A brain cancer that has material basis in glial cells.

MalaCards based summary : Brain Glioma, also known as intracranial glioma, is related to glioma and oligoastrocytoma. An important gene associated with Brain Glioma is TP73-AS1 (TP73 Antisense RNA 1), and among its related pathways/superpathways are Pathways in cancer and Proteoglycans in cancer. The drugs Temozolomide and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and breast, and related phenotypes are liver/biliary system and neoplasm

Related Diseases for Brain Glioma

Diseases related to Brain Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 196)
# Related Disease Score Top Affiliating Genes
1 glioma 32.1 TP73-AS1 TP53 MIR34A GAS5 EGFR
2 oligoastrocytoma 31.2 MGMT GFAP
3 malignant glioma 31.0 VEGFA TP53 MGMT GFAP GAS5 EGFR
4 oligodendroglioma 31.0 VEGFA TP53 MGMT GFAP EGFR
5 benign ependymoma 30.9 NES MGMT GFAP EGFR
6 grade iii astrocytoma 30.8 VEGFA TP53 NES MGMT GFAP EGFR
7 brain cancer 30.8 VEGFA TP53 NOTCH1 NES MGMT GFAP
8 glioblastoma multiforme 30.8 VEGFA TP53 PLK1 NOTCH1 NES MIR34A
9 fibrillary astrocytoma 30.7 TP53 MGMT GFAP EGFR
10 giant cell glioblastoma 30.7 TP53 MGMT GFAP EGFR
11 gemistocytic astrocytoma 30.6 TP53 MGMT GFAP
12 meningioma, familial 30.4 VEGFA TP53 MIR34A MGMT GFAP EGFR
13 mixed glioma 30.3 TP53 NES MGMT GFAP EGFR
14 hydrocephalus 30.2 VEGFA TP53 NOTCH1 NES GFAP
15 gliosarcoma 30.2 VEGFA TP53 NES MGMT GFAP EGFR
16 glioma susceptibility 1 29.9 VEGFA TP73-AS1 TP53 PTN NES MIR34A
17 pancreatic cancer 29.8 VEGFA TP53 PLK1 NOTCH1 NES MIR34A
18 kidney cancer 29.8 VEGFA TP53 GAS5 EGFR
19 bladder cancer 29.5 VEGFA TP53 PCAT29 MIR34A GAS5 EZH2
20 gastric cancer 29.5 VEGFA TP53 PLK1 NOTCH1 MIR34A MGMT
21 medulloblastoma 29.4 VEGFA TP53 PLK1 NOTCH1 NES MIR34A
22 neuroblastoma 29.2 VEGFA TP53 PLK1 NOTCH1 NES MIR34A
23 hepatocellular carcinoma 28.7 VEGFA TP73-AS1 TP53 PCAT29 NOTCH1 MIR34A
24 brain glioblastoma multiforme 11.2
25 brain oligodendroglioma 11.2
26 brain ependymoma 11.2
27 glial tumor 10.9
28 anaplastic ganglioglioma 10.7 NES GFAP
29 central nervous system immature teratoma 10.7 NES GFAP
30 pediatric angiosarcoma 10.7 VEGFA TP53
31 splenic diffuse red pulp small b-cell lymphoma 10.7 TP53 NOTCH1
32 frontal lobe neoplasm 10.6 TP53 MGMT EGFR
33 urethra transitional cell carcinoma 10.6 TP53 GFAP
34 esophageal basaloid squamous cell carcinoma 10.6 TP53 EGFR
35 esophagus verrucous carcinoma 10.6 TP53 EGFR
36 soft tissue sarcoma 10.6 VEGFA TP53 EGFR
37 polyploidy 10.6 TP53 PLK1
38 primary peritoneal carcinoma 10.6 VEGFA TP53 EGFR
39 cerebrovascular benign neoplasm 10.6 TP53 NES GFAP
40 pituitary carcinoma 10.6 TP53 MGMT GFAP
41 central nervous system primitive neuroectodermal neoplasm 10.6 TP53 NES GFAP
42 pleomorphic xanthoastrocytoma 10.6 TP53 MGMT GFAP
43 malignant ependymoma 10.6 MGMT GFAP EGFR
44 bone squamous cell carcinoma 10.6 TP53 NOTCH1 EGFR
45 ganglioglioma 10.6 TP53 NES GFAP
46 juvenile pilocytic astrocytoma 10.6 NES MGMT GFAP
47 pleural cancer 10.6 VEGFA TP53 EGFR
48 tonsil cancer 10.6 TP53 NOTCH1 EGFR
49 lung adenoma 10.6 TP53 NOTCH1 EGFR
50 pancreatic ductal carcinoma 10.6 VEGFA TP53 EGFR

Graphical network of the top 20 diseases related to Brain Glioma:



Diseases related to Brain Glioma

Symptoms & Phenotypes for Brain Glioma

MGI Mouse Phenotypes related to Brain Glioma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 liver/biliary system MP:0005370 9.8 BMP4 EGFR FASLG NOTCH1 PTN TP53
2 neoplasm MP:0002006 9.76 EGFR EZH2 FASLG MGMT NOTCH1 PLK1
3 nervous system MP:0003631 9.7 BMP4 EGFR EZH2 FASLG GFAP MGMT
4 respiratory system MP:0005388 9.23 BMP4 EGFR EZH2 FASLG MGMT NOTCH1

Drugs & Therapeutics for Brain Glioma

Drugs for Brain Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 113)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Temozolomide Approved, Investigational Phase 3 85622-93-1 5394
2 Alkylating Agents Phase 3
3
Ethanol Approved Phase 1, Phase 2 64-17-5 702
4
Carmustine Approved, Investigational Phase 2 154-93-8 2578
5
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
6
Lomustine Approved, Investigational Phase 2 13010-47-4 3950
7
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
8
Thioguanine Approved Phase 2 154-42-7 2723601
9
Citalopram Approved Phase 2 59729-33-8 2771
10
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
11
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
12
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
13
Memantine Approved, Investigational Phase 2 19982-08-2 4054
14
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
15
Aminolevulinic acid Approved Phase 2 106-60-5 137
16
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
17
Panitumumab Approved, Investigational Phase 2 339177-26-3 50070211
18 Anti-Infective Agents Phase 1, Phase 2
19 Anti-Infective Agents, Local Phase 1, Phase 2
20 Analgesics, Non-Narcotic Phase 2
21 Analgesics Phase 2
22 Antirheumatic Agents Phase 2
23 Anti-Inflammatory Agents, Non-Steroidal Phase 2
24 Cyclooxygenase Inhibitors Phase 2
25 Cyclooxygenase 2 Inhibitors Phase 2
26 Anti-Inflammatory Agents Phase 2
27 Antimetabolites Phase 2
28 Immunoglobulins Phase 1, Phase 2
29 Antibodies Phase 1, Phase 2
30 Serotonin Uptake Inhibitors Phase 2
31 Neurotransmitter Agents Phase 2
32 Antiparkinson Agents Phase 2
33 Autonomic Agents Phase 2
34 Serotonin Agents Phase 2
35 Muscarinic Antagonists Phase 2
36 Cholinergic Agents Phase 2
37 Antidepressive Agents Phase 2
38 Cholinergic Antagonists Phase 2
39 Parasympatholytics Phase 2
40 Angiogenesis Inhibitors Phase 1, Phase 2
41 Excitatory Amino Acid Antagonists Phase 2
42 Excitatory Amino Acids Phase 2
43 Dopamine Agents Phase 2
44 Vaccines Phase 2
45 Anticonvulsants Phase 2
46 topoisomerase I inhibitors Phase 2
47 Topoisomerase Inhibitors Phase 2
48 Anesthetics Phase 2
49 Dermatologic Agents Phase 2
50 Photosensitizing Agents Phase 2

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Neuropsychological and Oncological Outcomes in Grade 2 or 3 Glioma Patients Undergoing Postoperative Modern Radiotherapy - A Prospective Follow-up Study Recruiting NCT03534050 Phase 2, Phase 3
2 IDH Mutated 1p/19q Intact Lower Grade Glioma Following Resection: Wait Or Treat? IWOT - a Phase III Study Not yet recruiting NCT03763422 Phase 3 Temozolomide
3 Carbon-11-Sodium Acetate Positron Emission Tomography/Computed Tomography (PET/CT) Imaging Evaluation in Brain Glioma, Post Therapy Necrosis and Pseudo-progression Withdrawn NCT01961934 Phase 2, Phase 3 Sodium Acetate C11 PET/CT Imaging
4 Immunotherapy With Chimeric Antigen Receptor-Modified T Cells for MUC1 Positive Advanced Refractory Solid Tumor Unknown status NCT02617134 Phase 1, Phase 2
5 A Phase 2 Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain Unknown status NCT01403311 Phase 2 5-Aminolevuline Acid
6 Phase I/II Study of Intratumoral Injection of DTI-015 Prior to Tumor Resection in Patients With Recurrent Malignant Glioma or Metastatic Neoplasm to Brain Unknown status NCT00009854 Phase 1, Phase 2 carmustine in ethanol
7 A Randomized Phase 2 Study to Evaluate the Efficacy Between Only Radiotherapy Versus CCRT With Temozolomide in Newly Diagnosed Grade III Gliomas Without 1p/19q Codeletion Unknown status NCT01534845 Phase 2 Temozolomide (Temodal)
8 Adenovirus-Mediated Delivery of Herpes Simplex Virus Thymidine Kinase Administration Improves Outcome of Recurrent High-Grade Glioma Completed NCT00870181 Phase 2 systemic chemotherapy
9 Combination of 6-Thioguanine, Capecitabine, Celecoxib and Temozolomide or CCNU for Recurrent Anaplastic Glioma and Glioblastoma Multiforme Completed NCT00504660 Phase 2 Capecitabine;Celecoxib (Celebrex);Temozolomide;Lomustine;6-Thioguanine
10 A Study to Evaluate the Safety and Efficacy of the Tumor-targeting Human Antibody-cytokine Fusion Protein L19TNF in Patients With Isocitrate Dehydrogenase (IDH) Wildtype WHO Grade III / IV Glioma at First Relapse Recruiting NCT03779230 Phase 1, Phase 2 L19TNF
11 A Randomized Feasibility Study Evaluating Temozolomide Chronotherapy for High Grade Glioma Recruiting NCT02781792 Phase 2 Temozolomide
12 A Pilot Study Utilizing Escitalopram to Address Cognitive Dysfunction in Glioma Patients Recruiting NCT03728673 Phase 2 Escitalopram Oral Tablet
13 Phase I/II Trial Of Super-Selective Intraarterial Infusion Of Erbitux (Cetuximab) And Avastin (Bevacizumab)For Treatment Of Relapsed/Refractory Intracranial Glioma In Patients Under 22 Years Of Age Recruiting NCT01884740 Phase 1, Phase 2 SIACI of Erbitux and Bevacizumab
14 Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors: A Pilot Study Recruiting NCT03194906 Phase 2 Memantine
15 A Large-scale Research for Immunotherapy of Glioblastoma With Autologous Heat Shock Protein gp96 Not yet recruiting NCT03650257 Phase 2 Temozolomide
16 Phase II Study of Panitumumab in Combination With Irinotecan for Malignant Gliomas Terminated NCT01017653 Phase 2 Irinotecan;Panitumumab
17 A Phase 2 Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Tumors of the Brain Terminated NCT01116661 Phase 2 5-Aminolevuline Acid (ALA)
18 A Phase I/II Trial Of STI571 In Children With Newly Diagnosed Poor Prognosis Brainstem Gliomas And Recurrent Intracranial Malignant Gliomas Terminated NCT00021229 Phase 1, Phase 2 imatinib mesylate
19 A Phase I Study of DB-67 (7-t-butyldimethylsilyl-10-hydroxycamptothecin) in Adult Patients With Refractory or Metastatic Solid Malignancies Completed NCT00389480 Phase 1 AR-67 (formerly DB-67)
20 A Phase I, Sequential Cohort, Open-Label, Dose-escalation Study of the Safety and CNS Pharmacokinetics of Dexanabinol in Patients With Brain Cancer Completed NCT01654497 Phase 1 Dexanabinol
21 Phase 1 Study in Humans Evaluating the Safety of Rectus Sheath Implantation of Diffusion Chambers Encapsulating Autologous Malignant Glioma Cells Treated With Insulin-Like Growth Factor Receptor-1 Antisense Oligodeoxynucleotide in 12 Patients With Recurrent Malignant Glioma Completed NCT01550523 Phase 1 IGF-1R/AS ODN
22 A Phase I Study of Safety and Tolerability of Acetazolamide With Temozolomide in Adults With Newly Diagnosed MGMT Promoter-Methylated Malignant Glioma Recruiting NCT03011671 Phase 1 Acetazolamide;Temozolomide
23 A Phase I Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2, a Genetically Engineered HSV-1 Virus, and Immunomodulation With Cyclophosphamide Recruiting NCT03152318 Phase 1 rQNestin;Cyclophosphamide
24 A Phase I and Feasibility Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine for Pediatric Patients With Newly Diagnosed Intracranial High Grade Glioma and Recurrent Resectable Intracranial High Grade Glioma and Ependymoma Recruiting NCT02722512 Phase 1
25 Glioma Microenvironment an Exploratory Study Unknown status NCT03189420
26 A Prospective Study of Concurrent Chemoradiotherapy With Temozolomide Versus Radiation Therapy Alone in Patients With IDH Wild-type/TERT Promoter Mutation Grade II/III Gliomas Unknown status NCT02766270 Early Phase 1 Temozolomide
27 IRDye800CW-BBN PET-NIRF in Lower Grade Glioma Unknown status NCT03407781 Early Phase 1 68Ga-BBN-IRDye800CW
28 Noninvasively Predicting Isocitrate Dehydrogenase Gene Status in Glioma by Amide Proton Transfer Imaging Unknown status NCT03102112
29 A Pilot Randomized Controlled Trial on the Feasibility and Efficacy of an Exercise Intervention to Improve Cognitive Functioning in Patients With Glioma Completed NCT02303938
30 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
31 A Family Study of Adults With Glioma Completed NCT00339352
32 Early Detection and Paramedical Care of Sexual Difficulties in Nervous System Diseases: Example of Multiple Sclerosis and Brain Tumors Recruiting NCT03154801
33 Registry Describing Clinical Information, Conventional, and Advanced Magnetic Resonance Imaging Information of Patients With Brain Glioma Recruiting NCT02619890
34 A Study of Intratumorally-Administered Topotecan Using Convection-Enhanced Delivery (CED) in Patients With Suspected Recurrent/Progressive World Health Organization (WHO) Grade III or IV (High Grade) Glioma Undergoing Stereotactic Biopsy Recruiting NCT03927274 Early Phase 1 Topotecan
35 Randomized Control Trial for Awake vs. Asleep Craniotomy for Non-eloquent Gliomas Recruiting NCT03621748
36 Are Gliomas in Adults Associated With a Unique Identifying Blood Biomarker Signature? Recruiting NCT03698201
37 A New Strategy for the Visulation of Molecular Genotype in Glioma Evolution Based on the Radiomics and Microomics Recruiting NCT03750890
38 Feasibility of the LUM Imaging System for In Vivo and Ex Vivo Detection of Cancer in Subjects With Low Grade Gliomas, Glioblastomas, and Cancer Metastases to the Brain Recruiting NCT03717142
39 Pilot Study of Mirtazapine for the Dual Treatment of Depression and Temozolomide-Induced Nausea and Vomiting (CINV) in Newly-Diagnosed High-Grade Glioma Patients on Temozolomide Therapy Recruiting NCT03935685 Early Phase 1 Mirtazapine (Remeron)
40 Longitudinal Analysis of the Health-related Quality of Life in Glioma Patients and Setting up a Large-scale, Prospective Database for Glioma Patients Treated in UZ Leuven Recruiting NCT03849430
41 Pilot Study: Measure of the Potential Evoked With Electroencephalography and Electrocorticography by Electric Stimulation of the Brain During the Neurosurgery Awakened of the Infiltrative Glioma of Low Grade (OMS Type II) Active, not recruiting NCT02509442
42 Efficacy of Hospital Traditional Chinese Medicine Preparation Kangliuwan for Recurrent Grade IV Glioma: A Prospective Exploratory Clinical Study Not yet recruiting NCT03949192
43 Early Post-surgical Temozolomide Therapy in Patients With High-Grade Gliomas Admitted to Acute Rehabilitation: A Feasibility Study Not yet recruiting NCT03796507 Early Phase 1 Temozolomide
44 The Use of Focused Ultrasound and Microbubble Infusion for Altering Brain Perfusion and the Blood Brain Barrier Not yet recruiting NCT04063514
45 The Effects of Mild Sedation on Compensatory Upper Limb Motor Function Networks Based on Multimodal Magnetic Resonance Imaging in With Gliomas in Brain Eloquent Areas Not yet recruiting NCT03984240 Midazolam;Dexmedetomidine
46 Image Guided Adaptive Multi-modality Therapy in the Treatment of Gliomas Terminated NCT01263821
47 (11C)N-Desmethyl-Loperamide as a Marker of P-Glycoprotein Function in Patients With Gliomas Terminated NCT01281982
48 Laser Interstitial Thermal Therapy (LITT) as Palliative Treatment for Patients With Malignant Glioma Requiring Standard Treatment Alternatives Withdrawn NCT03176160

Search NIH Clinical Center for Brain Glioma

Genetic Tests for Brain Glioma

Genetic tests related to Brain Glioma:

# Genetic test Affiliating Genes
1 Glioma of Brain 29

Anatomical Context for Brain Glioma

MalaCards organs/tissues related to Brain Glioma:

40
Brain, Lung, Breast, Spinal Cord, Bone, T Cells, Tongue

Publications for Brain Glioma

Articles related to Brain Glioma:

(show top 50) (show all 725)
# Title Authors PMID Year
1
High expression of ALDH1A3 might independently influence poor progression-free and overall survival in patients with glioma via maintaining glucose uptake and lactate production. 61
31642564 2020
2
A quantitative model based on clinically relevant MRI features differentiates lower grade gliomas and glioblastoma. 61
32025832 2020
3
Advanced imaging parameters improve the prediction of diffuse lower-grade gliomas subtype, IDH mutant with no 1p19q codeletion: added value to the T2/FLAIR mismatch sign. 61
31446467 2020
4
Network-based integrative clustering of multiple types of genomic data using non-negative matrix factorization. 61
31999549 2020
5
Imaging glioma biology: spatial comparison of amino acid PET, amide proton transfer, and perfusion-weighted MRI in newly diagnosed gliomas. 61
31953672 2020
6
Identification and validation of a three-gene signature as a candidate prognostic biomarker for lower grade glioma. 61
31921517 2020
7
A novel lncRNA-LINC01116 regulates tumorigenesis of glioma by targeting VEGFA. 61
31144303 2020
8
Salvianolic acid A increases the accumulation of doxorubicin in brain tumors through Caveolae endocytosis. 61
32014448 2020
9
Prediction of lower-grade glioma molecular subtypes using deep learning. 61
31865510 2020
10
Diffusion tensor imaging radiomics in lower-grade glioma: improving subtyping of isocitrate dehydrogenase mutation status. 61
31820065 2019
11
EGFR mutation: novel prognostic factor associated with immune infiltration in lower-grade glioma; an exploratory study. 61
31801484 2019
12
Novel Brain-Tumor-Inhibiting Copper(II) Compound Based on a Human Serum Albumin (HSA)-Cell Penetrating Peptide Conjugate. 61
31693353 2019
13
MIR155HG is a prognostic biomarker and associated with immune infiltration and immune checkpoint molecules expression in multiple cancers. 61
31568700 2019
14
A systematic analysis of immune genes and overall survival in cancer patients. 61
31842801 2019
15
Novel sphingomyelin biomarkers for brain glioma and associated regulation research on the PI3K/Akt signaling pathway. 61
31788096 2019
16
Diffusion- and perfusion-weighted MRI radiomics model may predict isocitrate dehydrogenase (IDH) mutation and tumor aggressiveness in diffuse lower grade glioma. 61
31828414 2019
17
Transcriptomic Profiling Identifies a DNA Repair-Related Signature as a Novel Prognostic Marker in Lower Grade Gliomas. 61
31533943 2019
18
Fusion Radiomics Features from Conventional MRI Predict MGMT Promoter Methylation Status in Lower Grade Gliomas. 61
31704598 2019
19
Ecotropic viral integration site 1 regulates EGFR transcription in glioblastoma cells. 61
31617054 2019
20
Radiomics Analysis for Glioma Malignancy Evaluation Using Diffusion Kurtosis and Tensor Imaging. 61
31344432 2019
21
Hans Joachim Scherer and His Impact on the Diagnostic, Clinical, and Modern Research Aspects of Glial Tumors. 61
31886082 2019
22
Chemical complementarity between immune receptor CDR3s and IDH1 mutants correlates with increased survival for lower grade glioma. 61
31740784 2019
23
Identification of Secreted Phosphoprotein 1 (SPP1) as a Prognostic Factor in Lower-Grade Gliomas. 61
31295606 2019
24
The Korean Society for Neuro-Oncology (KSNO) Guideline for WHO Grade II Cerebral Gliomas in Adults: Version 2019.01. 61
31686437 2019
25
CLEC5A expressed on myeloid cells as a M2 biomarker relates to immunosuppression and decreased survival in patients with glioma. 61
31591460 2019
26
Molecular and clinical characterization of Galectin-9 in glioma through 1,027 samples. 61
31609000 2019
27
Expression of CD40 Correlates Negatively with Overall and Progression-Free Survival of Low- and High-Grade Gliomas. 61
31125770 2019
28
Advancing Pan-cancer Gene Expression Survial Analysis by Inclusion of Non-coding RNA. 61
31607216 2019
29
miR-124 participates in the proliferation and differentiation of brain glioma stem cells through regulating Nogo/NgR expression. 61
31572526 2019
30
[Research on glioma magnetic resonance imaging segmentation based on dual-channel three-dimensional densely connected network]. 61
31631624 2019
31
In vivo 1 H MRS detection of cystathionine in human brain tumors. 61
31131476 2019
32
Emerging Pathogenic and Prognostic Significance of Paired Box 3 (PAX3) Protein in Adult Gliomas. 61
31352198 2019
33
An independently validated survival nomogram for lower grade glioma. 61
31621885 2019
34
Maternal fructose-induced oxidative stress occurs viaTfam and Ucp5 epigenetic regulation in offspring hippocampi. 61
31314594 2019
35
Reclassification of Mongolian Diffuse Gliomas According to the Revised 2016 World Health Organization Central Nervous System Tumor Classification. 61
31370384 2019
36
Molecular Subtype Classification in Lower-Grade Glioma with Accelerated DTI. 61
31413006 2019
37
Total DNA Methylation Changes Reflect Random Oxidative DNA Damage in Gliomas. 61
31514401 2019
38
Herpes Simplex Encephalitis Initially Erroneously Diagnosed as Glioma of the Cerebellum: Case Report and Literature Review. 61
31254700 2019
39
Understanding the cellular uptake and biodistribution of a dual-targeting carrier based on redox-sensitive hyaluronic acid-ss-curcumin micelles for treating brain glioma. 61
31199976 2019
40
Brain gliomas, hydrocephalus and idiopathic aqueduct stenosis in children with neurofibromatosis type 1. 61
31000370 2019
41
Factor analysis for survival time prediction with informative censoring and diverse covariates. 61
31162708 2019
42
Glioma surgery under awake condition can lead to good independence and functional outcome excluding deep sensation and visuospatial cognition. 61
31555450 2019
43
A prognostic signature of five pseudogenes for predicting lower-grade gliomas. 61
31247469 2019
44
Estimating mean local posterior predictive benefit for biomarker-guided treatment strategies. 61
30037304 2019
45
The promising novel biomarkers and candidate small molecule drugs in lower-grade glioma: Evidence from bioinformatics analysis of high-throughput data. 61
31020692 2019
46
Deconvolution and network analysis of IDH-mutant lower grade glioma predict recurrence and indicate therapeutic targets. 61
31272213 2019
47
RNA processing genes characterize RNA splicing and further stratify lower-grade glioma. 61
31408440 2019
48
ZNF436 promotes tumor cell proliferation through transcriptional activation of BCL10 in glioma. 61
31178130 2019
49
Study of in vivo brain glioma in a mouse model using continuous-wave terahertz reflection imaging. 61
31452987 2019
50
The treatment effects and the underlying mechanism of B cell translocation gene 1 on the oncogenesis of brain glioma. 61
30916818 2019

Variations for Brain Glioma

Expression for Brain Glioma

Search GEO for disease gene expression data for Brain Glioma.

Pathways for Brain Glioma

GO Terms for Brain Glioma

Biological processes related to Brain Glioma according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of transcription by RNA polymerase II GO:0000122 10.05 VEGFA TP53 PLK1 NOTCH1 FASLG EZH2
2 negative regulation of apoptotic process GO:0043066 10.01 VEGFA TP53 PLK1 MGMT EGFR BMP4
3 positive regulation of gene expression GO:0010628 10 VEGFA TP53 NOTCH1 MIR34A BMP4
4 positive regulation of apoptotic process GO:0043065 9.97 TP53 PTN NOTCH1 FASLG BMP4
5 heart development GO:0007507 9.94 TP53 PTN NOTCH1 BMP4
6 regulation of cell proliferation GO:0042127 9.9 TP53 NOTCH1 EZH2 EGFR
7 negative regulation of gene expression GO:0010629 9.89 VEGFA TP53 NOTCH1 EZH2 BMP4
8 cellular response to hypoxia GO:0071456 9.85 VEGFA TP53 PTN MIR34A
9 positive regulation of cell migration GO:0030335 9.83 VEGFA SDCBP NOTCH1 EGFR BMP4
10 liver development GO:0001889 9.81 PTN NOTCH1 EGFR
11 negative regulation of cell death GO:0060548 9.79 NOTCH1 MGMT BMP4
12 positive regulation of MAP kinase activity GO:0043406 9.77 VEGFA EZH2 EGFR
13 outflow tract morphogenesis GO:0003151 9.75 VEGFA NOTCH1 BMP4
14 positive regulation of epithelial cell proliferation GO:0050679 9.67 VEGFA NOTCH1 EGFR BMP4
15 cardiac septum morphogenesis GO:0060411 9.66 TP53 NOTCH1
16 protein localization to chromatin GO:0071168 9.65 PLK1 EZH2
17 epithelial to mesenchymal transition involved in endocardial cushion formation GO:0003198 9.65 NOTCH1 BMP4
18 positive regulation of leukocyte migration GO:0002687 9.65 VEGFA TP53
19 positive regulation of cell cycle arrest GO:0071158 9.65 TP53 MYBBP1A MIR34A
20 endocardial cushion development GO:0003197 9.64 NOTCH1 BMP4
21 negative regulation of glial cell proliferation GO:0060253 9.63 PTN NOTCH1
22 branching morphogenesis of an epithelial tube GO:0048754 9.63 VEGFA NOTCH1 BMP4
23 tube formation GO:0035148 9.62 VEGFA NOTCH1
24 coronary artery morphogenesis GO:0060982 9.61 VEGFA NOTCH1
25 negative regulation of neuroblast proliferation GO:0007406 9.58 TP53 PTN
26 regulation of cell cycle G2/M phase transition GO:1902749 9.56 TP53 PLK1
27 positive regulation of epithelial to mesenchymal transition GO:0010718 9.56 SDCBP NOTCH1 EZH2 BMP4
28 cardiac vascular smooth muscle cell development GO:0060948 9.52 VEGFA NOTCH1
29 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.5 TP53 EGFR BMP4
30 coronary vein morphogenesis GO:0003169 9.4 VEGFA NOTCH1
31 lung development GO:0030324 9.35 VEGFA PTN NOTCH1 EGFR BMP4
32 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.33 VEGFA TP53 NOTCH1
33 positive regulation of cell proliferation GO:0008284 9.23 VEGFA SDCBP PTN NOTCH1 FASLG EZH2

Molecular functions related to Brain Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 syndecan binding GO:0045545 8.62 SDCBP PTN

Sources for Brain Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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