Brain Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Glioma

MalaCards integrated aliases for Brain Glioma:

Name: Brain Glioma 12 15
Intracranial Glioma 72
Lower Grade Glioma 12
Glioma of Brain 29


External Ids:

Disease Ontology 12 DOID:0060108
UMLS 72 C3665419

Summaries for Brain Glioma

Disease Ontology : 12 A brain cancer that has material basis in glial cells.

MalaCards based summary : Brain Glioma, also known as intracranial glioma, is related to brain ependymoma and ependymoma. An important gene associated with Brain Glioma is TP73-AS1 (TP73 Antisense RNA 1), and among its related pathways/superpathways are Pathways in cancer and Human cytomegalovirus infection. The drugs Temozolomide and Alkylating Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and endothelial, and related phenotypes are cardiovascular system and digestive/alimentary

Related Diseases for Brain Glioma

Diseases related to Brain Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 169)
# Related Disease Score Top Affiliating Genes
1 brain ependymoma 32.8 TP53 EGFR
2 ependymoma 30.6 NES MGMT GFAP EGFR
3 meningioma, familial 30.4 VEGFA TP53 GFAP
4 oligoastrocytoma 30.1 MGMT IDH2 GFAP
5 li-fraumeni syndrome 30.0 TP53 IDH1 EGFR
6 glioma 29.9 VEGFA TP73-AS1 TP53 IDH2 IDH1 EGFR
7 mixed glioma 29.9 TP53 IDH1 GFAP
8 glioblastoma multiforme 29.8 VEGFA TP53 NES MGMT IDH1 GFAP
9 gemistocytic astrocytoma 29.7 IDH2 GFAP
10 anaplastic oligodendroglioma 29.6 MGMT IDH2 GFAP EGFR
11 giant cell glioblastoma 29.5 TP53 MGMT IDH1 GFAP EGFR
12 grade iii astrocytoma 29.3 VEGFA TP53 MGMT IDH2 GFAP EGFR
13 bladder cancer 29.2 VEGFA TP53 PCAT29 EGFR DRAIC
14 glioblastoma 29.0 VEGFA TP73-AS1 TP53 MGMT IDH2 IDH1
15 glioma susceptibility 1 29.0 TP53 IDH2 IDH1 GFAP
16 gliosarcoma 28.9 TP53 NES MGMT IDH1 GFAP EGFR
17 oligodendroglioma 28.8 TP53 MGMT IDH2 IDH1 GFAP EGFR
18 medulloblastoma 28.0 TP53 PAX3 NOTCH1 NES MGMT IDH1
19 fibrillary astrocytoma 28.0 TP53 MGMT IDH2 IDH1 GFAP ATRX
20 brain cancer 27.8 VEGFA TP53 NOTCH1 NES MGMT IDH2
21 brain glioblastoma multiforme 11.2
22 brain oligodendroglioma 11.2
23 glial tumor 10.9
24 frontal convexity meningioma 10.8 TP53 GFAP
25 gliofibroma 10.7 TP53 GFAP
26 anaplastic ganglioglioma 10.7 NES GFAP
27 cerebral convexity meningioma 10.7 TP53 GFAP
28 cellular ependymoma 10.7 TP53 GFAP
29 preretinal fibrosis 10.6 VEGFA GFAP
30 meninges sarcoma 10.6 TP53 GFAP
31 splenic diffuse red pulp small b-cell lymphoma 10.6 TP53 NOTCH1
32 recurrent respiratory papillomatosis 10.6 TP53 EGFR
33 spinal cancer 10.6 TP53 GFAP
34 invasive bladder transitional cell carcinoma 10.6 TP53 NOTCH1
35 cerebral neuroblastoma 10.6 TP53 GFAP
36 central nervous system germ cell tumor 10.6 NES GFAP
37 soft tissue sarcoma 10.5 VEGFA TP53 EGFR
38 primary peritoneal carcinoma 10.5 VEGFA TP53 EGFR
39 central nervous system primitive neuroectodermal neoplasm 10.5 TP53 NES GFAP
40 breast carcinoma in situ 10.5 VEGFA TP53 EGFR
41 ependymoblastoma 10.5 TP53 NES GFAP
42 pharynx cancer 10.5 VEGFA TP53 EGFR
43 optic nerve glioma 10.5 TP53 NES GFAP
44 infratentorial cancer 10.5 TP53 NES GFAP
45 colonic disease 10.5 VEGFA TP53 EGFR
46 ganglioglioma 10.5 TP53 NES GFAP
47 colorectal adenocarcinoma 10.5 VEGFA TP53 EGFR
48 laryngeal squamous cell carcinoma 10.5 VEGFA TP53 EGFR
49 stomach disease 10.5 VEGFA TP53 EGFR
50 breast squamous cell carcinoma 10.5 TP53 EGFR

Graphical network of the top 20 diseases related to Brain Glioma:

Diseases related to Brain Glioma

Symptoms & Phenotypes for Brain Glioma

MGI Mouse Phenotypes related to Brain Glioma:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 ATRX EGFR FASLG GFAP IDH2 NOTCH1
2 digestive/alimentary MP:0005381 9.87 EGFR FASLG GFAP NOTCH1 PAX3 TP53
3 neoplasm MP:0002006 9.86 EGFR FASLG IDH2 MGMT NOTCH1 PAX3
4 respiratory system MP:0005388 9.76 EGFR FASLG IDH1 MGMT NOTCH1 PAX3
5 skeleton MP:0005390 9.56 CREB3L1 EGFR FASLG IDH1 NOTCH1 PAX3
6 vision/eye MP:0005391 9.23 ATRX EGFR FASLG GFAP NOTCH1 PAX3

Drugs & Therapeutics for Brain Glioma

Drugs for Brain Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 119)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Temozolomide Approved, Investigational Phase 3 85622-93-1 5394
2 Alkylating Agents Phase 3
3 Antineoplastic Agents, Alkylating Phase 3
Carmustine Approved, Investigational Phase 2 154-93-8 2578
Celecoxib Approved, Investigational Phase 2 169590-42-5 2662
Lomustine Approved, Investigational Phase 2 13010-47-4 3950
Thioguanine Approved Phase 2 154-42-7 2723601
Capecitabine Approved, Investigational Phase 2 154361-50-9 60953
Citalopram Approved Phase 2 59729-33-8 2771
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
Memantine Approved, Investigational Phase 2 19982-08-2 4054
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
Aminolevulinic acid Approved Phase 2 106-60-5 137
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
Panitumumab Approved, Investigational Phase 2 339177-26-3 50070211
18 Peripheral Nervous System Agents Phase 2
19 Analgesics Phase 2
20 Analgesics, Non-Narcotic Phase 2
21 Antirheumatic Agents Phase 2
22 Anti-Inflammatory Agents Phase 2
23 Cyclooxygenase Inhibitors Phase 2
24 Cyclooxygenase 2 Inhibitors Phase 2
25 Antimetabolites, Antineoplastic Phase 2
26 Anti-Inflammatory Agents, Non-Steroidal Phase 2
27 Antimetabolites Phase 2
28 Antibodies Phase 1, Phase 2
29 Immunoglobulins Phase 1, Phase 2
30 Serotonin Uptake Inhibitors Phase 2
31 Antidepressive Agents Phase 2
32 Parasympatholytics Phase 2
33 Neurotransmitter Uptake Inhibitors Phase 2
34 Antidepressive Agents, Second-Generation Phase 2
35 Cholinergic Agents Phase 2
36 Muscarinic Antagonists Phase 2
37 Neurotransmitter Agents Phase 2
38 Cholinergic Antagonists Phase 2
39 Antiparkinson Agents Phase 2
40 Serotonin Agents Phase 2
41 Autonomic Agents Phase 2
42 Angiogenesis Inhibitors Phase 1, Phase 2
43 Angiogenesis Modulating Agents Phase 1, Phase 2
44 Excitatory Amino Acid Antagonists Phase 2
45 Excitatory Amino Acids Phase 2
46 Dopamine Agents Phase 2
47 Vaccines Phase 2
48 Anticonvulsants Phase 2
49 topoisomerase I inhibitors Phase 2
50 Topoisomerase Inhibitors Phase 2

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Neuropsychological and Oncological Outcomes in Grade 2 or 3 Glioma Patients Undergoing Postoperative Modern Radiotherapy - A Prospective Follow-up Study Recruiting NCT03534050 Phase 2, Phase 3
2 IDH Mutated 1p/19q Intact Lower Grade Glioma Following Resection: Wait Or Treat? IWOT - a Phase III Study Not yet recruiting NCT03763422 Phase 3 Temozolomide
3 Carbon-11-Sodium Acetate Positron Emission Tomography/Computed Tomography (PET/CT) Imaging Evaluation in Brain Glioma, Post Therapy Necrosis and Pseudo-progression Withdrawn NCT01961934 Phase 2, Phase 3 Sodium Acetate C11 PET/CT Imaging
4 Immunotherapy With Chimeric Antigen Receptor-Modified T Cells for MUC1 Positive Advanced Refractory Solid Tumor Unknown status NCT02617134 Phase 1, Phase 2
5 A Phase 2 Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Malignant Glial Tumors of the Brain Unknown status NCT01403311 Phase 2 5-Aminolevuline Acid
6 A Randomized Phase 2 Study to Evaluate the Efficacy Between Only Radiotherapy Versus CCRT With Temozolomide in Newly Diagnosed Grade III Gliomas Without 1p/19q Codeletion Unknown status NCT01534845 Phase 2 Temozolomide (Temodal)
7 Adenovirus-Mediated Delivery of Herpes Simplex Virus Thymidine Kinase Administration Improves Outcome of Recurrent High-Grade Glioma Completed NCT00870181 Phase 2 systemic chemotherapy
8 Combination of 6-Thioguanine, Capecitabine, Celecoxib and Temozolomide or CCNU for Recurrent Anaplastic Glioma and Glioblastoma Multiforme Completed NCT00504660 Phase 2 Capecitabine;Celecoxib (Celebrex);Temozolomide;Lomustine;6-Thioguanine
9 A Study to Evaluate the Safety and Efficacy of the Tumor-targeting Human Antibody-cytokine Fusion Protein L19TNF in Patients With Isocitrate Dehydrogenase (IDH) Wildtype WHO Grade III / IV Glioma at First Relapse Recruiting NCT03779230 Phase 1, Phase 2 L19TNF
10 A Pilot Study Utilizing Escitalopram to Address Cognitive Dysfunction in Glioma Patients Recruiting NCT03728673 Phase 2 Escitalopram Oral Tablet
11 Phase I/II Trial Of Super-Selective Intraarterial Infusion Of Erbitux (Cetuximab) And Avastin (Bevacizumab)For Treatment Of Relapsed/Refractory Intracranial Glioma In Patients Under 22 Years Of Age Recruiting NCT01884740 Phase 1, Phase 2 SIACI of Erbitux and Bevacizumab
12 Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors: A Pilot Study Recruiting NCT03194906 Phase 2 Memantine
13 A Large-scale Research for Immunotherapy of Glioblastoma With Autologous Heat Shock Protein gp96 Not yet recruiting NCT03650257 Phase 2 Temozolomide
14 Phase II Study of Panitumumab in Combination With Irinotecan for Malignant Gliomas Terminated NCT01017653 Phase 2 Irinotecan;Panitumumab
15 A Phase 2 Study of Aminolevulinic Acid (ALA) to Enhance Visualization and Resection of Tumors of the Brain Terminated NCT01116661 Phase 2 5-Aminolevuline Acid (ALA)
16 A Phase I Study of DB-67 (7-t-butyldimethylsilyl-10-hydroxycamptothecin) in Adult Patients With Refractory or Metastatic Solid Malignancies Completed NCT00389480 Phase 1 AR-67 (formerly DB-67)
17 A Phase I, Sequential Cohort, Open-Label, Dose-escalation Study of the Safety and CNS Pharmacokinetics of Dexanabinol in Patients With Brain Cancer Completed NCT01654497 Phase 1 Dexanabinol
18 Phase 1 Study in Humans Evaluating the Safety of Rectus Sheath Implantation of Diffusion Chambers Encapsulating Autologous Malignant Glioma Cells Treated With Insulin-Like Growth Factor Receptor-1 Antisense Oligodeoxynucleotide in 12 Patients With Recurrent Malignant Glioma Completed NCT01550523 Phase 1 IGF-1R/AS ODN
19 A Randomized Feasibility Study Evaluating Temozolomide Chronotherapy for High Grade Glioma Recruiting NCT02781792 Phase 1 Temozolomide
20 A Phase I Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2, a Genetically Engineered HSV-1 Virus, and Immunomodulation With Cyclophosphamide Recruiting NCT03152318 Phase 1 rQNestin;Cyclophosphamide
21 A Phase I and Feasibility Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine for Pediatric Patients With Newly Diagnosed Intracranial High Grade Glioma and Recurrent Resectable Intracranial High Grade Glioma and Ependymoma Recruiting NCT02722512 Phase 1
22 A Phase I Study of Safety and Tolerability of Acetazolamide With Temozolomide in Adults With Newly Diagnosed MGMT Promoter-Methylated Malignant Glioma Active, not recruiting NCT03011671 Phase 1 Acetazolamide;Temozolomide
23 Glioma Microenvironment an Exploratory Study Unknown status NCT03189420
24 A Prospective Study of Concurrent Chemoradiotherapy With Temozolomide Versus Radiation Therapy Alone in Patients With IDH Wild-type/TERT Promoter Mutation Grade II/III Gliomas Unknown status NCT02766270 Early Phase 1 Temozolomide
25 IRDye800CW-BBN PET-NIRF in Lower Grade Glioma Unknown status NCT03407781 Early Phase 1 68Ga-BBN-IRDye800CW
26 Noninvasively Predicting Isocitrate Dehydrogenase Gene Status in Glioma by Amide Proton Transfer Imaging Unknown status NCT03102112
27 A Pilot Randomized Controlled Trial on the Feasibility and Efficacy of an Exercise Intervention to Improve Cognitive Functioning in Patients With Glioma Completed NCT02303938
28 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
29 A Family Study of Adults With Glioma Completed NCT00339352
30 Early Detection and Paramedical Care of Sexual Difficulties in Nervous System Diseases: Example of Multiple Sclerosis and Brain Tumors Recruiting NCT03154801
31 Registry Describing Clinical Information, Conventional, and Advanced Magnetic Resonance Imaging Information of Patients With Brain Glioma Recruiting NCT02619890
32 A Study of Intratumorally-Administered Topotecan Using Convection-Enhanced Delivery (CED) in Patients With Suspected Recurrent/Progressive World Health Organization (WHO) Grade III or IV (High Grade) Glioma Undergoing Stereotactic Biopsy Recruiting NCT03927274 Early Phase 1 Topotecan
33 Randomized Control Trial for Awake vs. Asleep Craniotomy for Non-eloquent Gliomas Recruiting NCT03621748
34 Are Gliomas in Adults Associated With a Unique Identifying Blood Biomarker Signature? Recruiting NCT03698201
35 A New Strategy for the Visulation of Molecular Genotype in Glioma Evolution Based on the Radiomics and Microomics Recruiting NCT03750890
36 Feasibility of the LUM Imaging System for In Vivo and Ex Vivo Detection of Cancer in Subjects With Low Grade Gliomas, Glioblastomas, and Cancer Metastases to the Brain Recruiting NCT03717142
37 Pilot Study of Mirtazapine for the Dual Treatment of Depression and Temozolomide-Induced Nausea and Vomiting (CINV) in Newly-Diagnosed High-Grade Glioma Patients on Temozolomide Therapy Recruiting NCT03935685 Early Phase 1 Mirtazapine (Remeron)
38 Longitudinal Analysis of the Health-related Quality of Life in Glioma Patients and Setting up a Large-scale, Prospective Database for Glioma Patients Treated in UZ Leuven Recruiting NCT03849430
39 Pilot Study: Measure of the Potential Evoked With Electroencephalography and Electrocorticography by Electric Stimulation of the Brain During the Neurosurgery Awakened of the Infiltrative Glioma of Low Grade (OMS Type II) Active, not recruiting NCT02509442
40 Efficacy of Hospital Traditional Chinese Medicine Preparation Kangliuwan for Recurrent Grade IV Glioma: A Prospective Exploratory Clinical Study Not yet recruiting NCT03949192
41 Early Post-surgical Temozolomide Therapy in Patients With High-Grade Gliomas Admitted to Acute Rehabilitation: A Feasibility Study Not yet recruiting NCT03796507 Early Phase 1 Temozolomide
42 The Use of Focused Ultrasound and Microbubble Infusion for Altering Brain Perfusion and the Blood Brain Barrier Not yet recruiting NCT04063514
43 The Effects of Mild Sedation on Compensatory Upper Limb Motor Function Networks Based on Multimodal Magnetic Resonance Imaging in With Gliomas in Brain Eloquent Areas Not yet recruiting NCT03984240 Midazolam;Dexmedetomidine
44 Image Guided Adaptive Multi-modality Therapy in the Treatment of Gliomas Terminated NCT01263821
45 (11C)N-Desmethyl-Loperamide as a Marker of P-Glycoprotein Function in Patients With Gliomas Terminated NCT01281982
46 Laser Interstitial Thermal Therapy (LITT) as Palliative Treatment for Patients With Malignant Glioma Requiring Standard Treatment Alternatives Withdrawn NCT03176160

Search NIH Clinical Center for Brain Glioma

Genetic Tests for Brain Glioma

Genetic tests related to Brain Glioma:

# Genetic test Affiliating Genes
1 Glioma of Brain 29

Anatomical Context for Brain Glioma

MalaCards organs/tissues related to Brain Glioma:

Brain, T Cells, Endothelial, Lung, Bone, Kidney, Spinal Cord

Publications for Brain Glioma

Articles related to Brain Glioma:

(show top 50) (show all 687)
# Title Authors PMID Year
In vivo 1 H MRS detection of cystathionine in human brain tumors. 38
31131476 2019
Herpes Simplex Encephalitis Initially Erroneously Diagnosed as Glioma of the Cerebellum: Case Report and Literature Review. 38
31254700 2019
The promising novel biomarkers and candidate small molecule drugs in lower-grade glioma: Evidence from bioinformatics analysis of high-throughput data. 38
31020692 2019
Factor analysis for survival time prediction with informative censoring and diverse covariates. 38
31162708 2019
Understanding the cellular uptake and biodistribution of a dual-targeting carrier based on redox-sensitive hyaluronic acid-ss-curcumin micelles for treating brain glioma. 38
31199976 2019
A prognostic signature of five pseudogenes for predicting lower-grade gliomas. 38
31247469 2019
ZNF436 promotes tumor cell proliferation through transcriptional activation of BCL10 in glioma. 38
31178130 2019
The treatment effects and the underlying mechanism of B cell translocation gene 1 on the oncogenesis of brain glioma. 38
30916818 2019
Molecular Subtype Classification in Lower-Grade Glioma with Accelerated DTI. 38
31413006 2019
Integrating multiple-level molecular data to infer the distinctions between glioblastoma and lower-grade glioma. 38
30694558 2019
RNA processing genes characterize RNA splicing and further stratify lower-grade glioma. 38
31408440 2019
Reclassification of Mongolian Diffuse Gliomas According to the Revised 2016 World Health Organization Central Nervous System Tumor Classification. 38
31370384 2019
Evaluation of Tumor Hypoxia in C6 Glioma Rat Model With Dynamic Contrast-Enhanced Magnetic Resonance Imaging. 38
30385206 2019
Analysis of clinical characteristics of macrophage capping protein (CAPG) gene expressed in glioma based on TCGA data and clinical experiments. 38
31423196 2019
Maternal fructose-induced oxidative stress occurs viaTfam and Ucp5 epigenetic regulation in offspring hippocampi. 38
31314594 2019
Inflammatory activation of microglia by Staphylococcus aureus caused phenotypic alterations and affected glioblastoma growth. 38
31045268 2019
Deconvolution and network analysis of IDH-mutant lower grade glioma predict recurrence and indicate therapeutic targets. 38
31272213 2019
Emerging Pathogenic and Prognostic Significance of Paired Box 3 (PAX3) Protein in Adult Gliomas. 38
31352198 2019
LncRNA GAS5 regulates the proliferation, migration, invasion and apoptosis of brain glioma cells through targeting GSTM3 expression. The effect of LncRNA GAS5 on glioma cells. 38
31172354 2019
Combined PET/MRI in brain glioma imaging. 38
31283392 2019
Extent of Surgical Resection in Lower-Grade Gliomas: Differential Impact Based on Molecular Subtype. 38
31248860 2019
Next-generation whole exome sequencing of glioblastoma with a primitive neuronal component. 38
30715630 2019
Bayesian personalized treatment selection strategies that integrate predictive with prognostic determinants. 38
30786040 2019
Identification of Secreted Phosphoprotein 1 (SPP1) as a Prognostic Factor in Lower-Grade Gliomas. 38
31295606 2019
Radiomics analysis for glioma malignancy evaluation using diffusion kurtosis and tensor imaging. 38
31344432 2019
Prognostic significance of MEOX2 in gliomas. 38
30659268 2019
Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth. 38
30761522 2019
Association of genomic subtypes of lower-grade gliomas with shape features automatically extracted by a deep learning algorithm. 38
31078126 2019
The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism. 38
31221981 2019
Realization of 19F MRI oximetry method using perfluorodecalin. 38
30730024 2019
Overexpression of Hsc70 promotes proliferation, migration, and invasion of human glioma cells. 38
30816582 2019
A novel lncRNA-LINC01116 regulates tumorigenesis of glioma by targeting VEGFA. 38
31144303 2019
The Germline Variants rs61757955 and rs34988193 Are Predictive of Survival in Lower Grade Glioma Patients. 38
30651372 2019
Use of Genome-Scale Integrated Analysis to Identify Key Genes and Potential Molecular Mechanisms in Recurrence of Lower-Grade Brain Glioma. 38
31104065 2019
Can dynamic contrast-enhanced MRI evaluate VEGF expression in brain glioma? An MRI-guided stereotactic biopsy study. 38
29752976 2019
CA10 and CA11 negatively regulate neuronal activity-dependent growth of gliomas. 38
30636076 2019
Expression of CD40 Correlates Negatively with Overall and Progression-Free Survival of Low- and High-Grade Gliomas. 38
31125770 2019
Prospective Clinical Sequencing of Adult Glioma. 38
30926639 2019
A single factor induces neuronal differentiation to suppress glioma cell growth. 38
30264483 2019
Identification of tissue-specific tumor biomarker using different optimization algorithms. 38
30535858 2019
Low LINC00599 expression is a poor prognostic factor in glioma. 38
30867254 2019
Microvascular characteristics of lower-grade diffuse gliomas: investigating vessel size imaging for differentiating grades and subtypes. 38
30276676 2019
Brain gliomas, hydrocephalus and idiopathic aqueduct stenosis in children with neurofibromatosis type 1. 38
31000370 2019
von Willebrand Factor Gene Expression in Primary Lower Grade Glioma: Mutually Co-Occurring Mutations in von Willebrand Factor, ATRX, and TP53. 38
31062529 2019
Joint bioinformatics analysis of underlying potential functions of hsa-let-7b-5p and core genes in human glioma. 38
30995921 2019
Prognostic significance of genetic biomarkers in isocitrate dehydrogenase-wild-type lower-grade glioma: the need to further stratify this tumor entity - a meta-analysis. 38
30298540 2019
Discovery of 5-Signature Predicting Survival of Patients with Lower-Grade Glioma. 38
30853516 2019
Tri-block copolymer nanoparticles modified with folic acid for temozolomide delivery in glioblastoma. 38
30660689 2019
Evaluation of biologically synthesized Au-CuO and CuO-ZnO nanoparticles against glioma cells and microorganisms. 38
30976181 2019
Blockade of a Laminin-411-Notch Axis with CRISPR/Cas9 or a Nanobioconjugate Inhibits Glioblastoma Growth through Tumor-Microenvironment Cross-talk. 38
30659021 2019

Variations for Brain Glioma

Expression for Brain Glioma

Search GEO for disease gene expression data for Brain Glioma.

Pathways for Brain Glioma

Pathways related to Brain Glioma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
6 11.83 TP53 GFAP EGFR
7 11.79 VEGFA TP53 FASLG
8 11.76 TP53 MGMT EGFR
9 11.69 PAX3 NOTCH1 GFAP
10 11.5 VEGFA TP53 EGFR
11 11.43 TP53 NOTCH1 ATRX
12 11.42 TP53 IDH1 EGFR
14 11.14 TP53 FASLG EGFR
15 11.04 VEGFA TP53 FASLG
16 10.82 VEGFA NOTCH1
17 10.78 VEGFA NOTCH1
Show member pathways
10.61 IDH2 IDH1

GO Terms for Brain Glioma

Cellular components related to Brain Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 VEGFA NOTCH1 HLA-F FASLG EGFR

Biological processes related to Brain Glioma according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.95 VEGFA TP53 PAX3 NOTCH1 EGFR CREB3L1
2 multicellular organism development GO:0007275 9.91 VEGFA TP53 PAX3 NOTCH1 NES EGFR
3 lung development GO:0030324 9.72 VEGFA NOTCH1 EGFR
4 positive regulation of epithelial cell proliferation GO:0050679 9.61 VEGFA NOTCH1 EGFR
5 DNA damage response, signal transduction by p53 class mediator GO:0030330 9.56 TP53 ATRX
6 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990440 9.54 TP53 CREB3L1
7 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.52 TP53 EGFR
8 negative regulation of glial cell proliferation GO:0060253 9.51 NOTCH1 IDH2
9 NADP metabolic process GO:0006739 9.49 IDH2 IDH1
10 coronary artery morphogenesis GO:0060982 9.48 VEGFA NOTCH1
11 tube formation GO:0035148 9.46 VEGFA NOTCH1
12 positive regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061419 9.32 VEGFA NOTCH1
13 isocitrate metabolic process GO:0006102 9.26 IDH2 IDH1
14 cardiac vascular smooth muscle cell development GO:0060948 9.16 VEGFA NOTCH1
15 glyoxylate cycle GO:0006097 8.96 IDH2 IDH1
16 coronary vein morphogenesis GO:0003169 8.62 VEGFA NOTCH1

Molecular functions related to Brain Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.55 TP53 NOTCH1 EGFR CREB3L1 ATRX
2 isocitrate dehydrogenase activity GO:0004448 8.96 IDH2 IDH1
3 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.62 IDH2 IDH1

Sources for Brain Glioma

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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