MCID: BRN032
MIFTS: 45

Brain Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Glioma

MalaCards integrated aliases for Brain Glioma:

Name: Brain Glioma 12 15
Intracranial Glioma 74
Lower Grade Glioma 12
Glioma of Brain 30

Classifications:



External Ids:

Disease Ontology 12 DOID:0060108
UMLS 74 C3665419

Summaries for Brain Glioma

Disease Ontology : 12 A brain cancer that has material basis in glial cells.

MalaCards based summary : Brain Glioma, also known as intracranial glioma, is related to glioma susceptibility 1 and brain ependymoma. An important gene associated with Brain Glioma is TP73-AS1 (TP73 Antisense RNA 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Glioblastoma Multiforme. The drugs Carmustine and Cobalt have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and t cells, and related phenotypes are cellular and cardiovascular system

Related Diseases for Brain Glioma

Diseases related to Brain Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 glioma susceptibility 1 32.3 GFAP TP53
2 brain ependymoma 32.1 EGFR TP53
3 glioblastoma 30.4 EGFR MGMT TP53 TP73-AS1
4 glioblastoma multiforme 30.1 EGFR GFAP MGMT NES TP53
5 brain glioblastoma multiforme 11.0
6 brain oligodendroglioma 11.0
7 glioma 10.9
8 frontal convexity meningioma 10.4 GFAP TP53
9 gliofibroma 10.4 GFAP TP53
10 cerebral convexity meningioma 10.4 GFAP TP53
11 oligoastrocytoma 10.4 GFAP MGMT
12 cellular ependymoma 10.4 GFAP TP53
13 protoplasmic astrocytoma 10.4 GFAP TP53
14 meninges sarcoma 10.4 GFAP TP53
15 cerebral neuroblastoma 10.4 GFAP TP53
16 mixed glioma 10.4 GFAP TP53
17 recurrent respiratory papillomatosis 10.4 EGFR TP53
18 anaplastic ganglioglioma 10.4 GFAP NES
19 spinal cancer 10.4 GFAP TP53
20 central nervous system germ cell tumor 10.4 GFAP NES
21 cerebral ventricle cancer 10.3 GFAP TP53
22 dysembryoplastic neuroepithelial tumor 10.3 GFAP NES
23 breast squamous cell carcinoma 10.3 EGFR TP53
24 chordoid glioma 10.3 GFAP TP53
25 brain stem cancer 10.3 NES TP53
26 astroblastoma 10.3 GFAP NES
27 splenic diffuse red pulp small b-cell lymphoma 10.3 NOTCH1 TP53
28 invasive bladder transitional cell carcinoma 10.3 NOTCH1 TP53
29 malignant ependymoma 10.3 GFAP TP53
30 fibrillary astrocytoma 10.3 GFAP MGMT TP53
31 pleomorphic xanthoastrocytoma 10.3 GFAP MGMT TP53
32 medulloepithelioma 10.3 GFAP NES
33 microglandular adenosis 10.3 EGFR TP53
34 anaplastic oligodendroglioma 10.3 EGFR GFAP MGMT
35 central nervous system primitive neuroectodermal neoplasm 10.3 GFAP NES TP53
36 ependymoblastoma 10.3 GFAP NES TP53
37 optic nerve glioma 10.3 GFAP NES TP53
38 infratentorial cancer 10.3 GFAP NES TP53
39 ganglioglioma 10.2 GFAP NES TP53
40 subependymoma 10.2 GFAP NES
41 pleomorphic carcinoma 10.2 EGFR TP53
42 teratoma 10.2 GFAP NES TP53
43 pulmonary blastoma 10.2 EGFR TP53
44 lynch syndrome 10.2 EGFR MGMT TP53
45 nervous system disease 10.2 GFAP NES TP53
46 chronic venous leg ulcers 10.2 FASLG TP53
47 gallbladder cancer 10.2 EGFR MGMT TP53
48 tanycytic ependymoma 10.2 GFAP NES
49 gastrointestinal stromal tumor 10.1 EGFR NES TP53
50 giant cell glioblastoma 10.1 EGFR GFAP MGMT TP53

Graphical network of the top 20 diseases related to Brain Glioma:



Diseases related to Brain Glioma

Symptoms & Phenotypes for Brain Glioma

MGI Mouse Phenotypes related to Brain Glioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.09 CREB3L1 EGFR FASLG GFAP NOTCH1 PAX3
2 cardiovascular system MP:0005385 10.06 EGFR FASLG GFAP NOTCH1 PAX3 ROBO1
3 digestive/alimentary MP:0005381 10.01 EGFR FASLG GFAP NOTCH1 PAX3 ROBO1
4 endocrine/exocrine gland MP:0005379 9.97 EGFR FASLG MGMT NOTCH1 PAX3 ROBO1
5 integument MP:0010771 9.87 EGFR FASLG NOTCH1 PAX3 ROBO1 SLIT2
6 neoplasm MP:0002006 9.8 EGFR FASLG MGMT NOTCH1 PAX3 ROBO1
7 normal MP:0002873 9.7 EGFR FASLG GFAP NOTCH1 PAX3 ROBO1
8 renal/urinary system MP:0005367 9.5 EGFR FASLG NOTCH1 PAX3 ROBO1 SLIT2
9 respiratory system MP:0005388 9.17 EGFR FASLG MGMT NOTCH1 PAX3 ROBO1

Drugs & Therapeutics for Brain Glioma

Drugs for Brain Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carmustine Approved, Investigational Phase 3 154-93-8 2578
2
Cobalt Approved, Experimental Phase 3 7440-48-4 104729
3
Dopamine Approved Phase 3,Phase 1 62-31-7, 51-61-6 681
4 Mitolactol Investigational Phase 3 10318-26-0
5 Antineoplastic Agents, Alkylating Phase 3,Phase 1
6 Alkylating Agents Phase 3,Phase 1
7 Neurotransmitter Agents Phase 3,Phase 1,Not Applicable
8 Dihydroxyphenylalanine Phase 3,Phase 1
9 Dopamine Agents Phase 3,Phase 1
10
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
11
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
12
Olaparib Approved Phase 2 763113-22-0 23725625
13 Angiogenesis Inhibitors Phase 1, Phase 2
14 Angiogenesis Modulating Agents Phase 1, Phase 2
15 Antineoplastic Agents, Immunological Phase 1, Phase 2
16 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
17
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
18
Dinoprost tromethamine Approved, Vet_approved 38562-01-5 5282415
19
Dinoprost Approved, Investigational 551-11-1 5283078
20
Tocopherol Approved, Investigational 1406-66-2 14986
21
Flumazenil Approved Not Applicable 78755-81-4 3373
22
Dexmedetomidine Approved, Vet_approved Not Applicable 113775-47-6 68602 5311068
23
Midazolam Approved, Illicit Not Applicable 59467-70-8 4192
24
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
25
Vitamin A Approved, Nutraceutical, Vet_approved 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
26
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
27 Tocotrienol Investigational 6829-55-6
28 Central Nervous System Depressants Not Applicable
29 Anesthetics Not Applicable
30 Vitamins
31 Protein C Inhibitor
32 retinol
33 8-epi-prostaglandin F2alpha
34 Tocopherols
35 Retinol palmitate
36 Fluorodeoxyglucose F18
37 Antioxidants
38 Tocotrienols
39 Catalase
40 Alpha 1-Antitrypsin
41 GABA Agents Not Applicable
42 Tranquilizing Agents Not Applicable
43 Hypnotics and Sedatives Not Applicable
44 Anesthetics, General Not Applicable
45 GABA Modulators Not Applicable
46 Adjuvants, Anesthesia Not Applicable
47 Anti-Anxiety Agents Not Applicable
48 Psychotropic Drugs Not Applicable
49 Anesthetics, Intravenous Not Applicable

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 C11-Sodium Acetate PET/CT Imaging Evaluation in Brain Glioma, Post Therapy Necrosis and Pseudo-progression Withdrawn NCT01961934 Phase 2, Phase 3 Sodium Acetate C11 PET/CT Imaging
2 Radiation Therapy in Treating Patients With Brain Cancer Completed NCT00002620 Phase 3 carmustine;chemotherapy;mitolactol
3 18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety Recruiting NCT03042416 Phase 3 18F-DOPA
4 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Recruiting NCT01884740 Phase 1, Phase 2 SIACI of Erbitux and Bevacizumab
5 Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations Recruiting NCT03212274 Phase 2 Olaparib
6 FDOPA-PET/MRI for the Pre-operative Evaluation of Gliomas Terminated NCT02371031 Phase 1 6-[F-18]-Fluoro-L-3,4,-dihydroxyphenylalanine
7 Temozolomide Chronotherapy for High Grade Glioma Recruiting NCT02781792 Phase 1 Temozolomide
8 Brain Glioma Registry Combining Clinical and Imaging Information Recruiting NCT02619890
9 Awake vs. Asleep Craniotomy for Non-eloquent Gliomas Not yet recruiting NCT03621748 Not Applicable
10 Image Guided Therapy in the Treatment of Gliomas Terminated NCT01263821 Not Applicable
11 Multimodality Imaging Combined With Multiple Targets Pathological Examination for Detecting of Biological Borders of Gliomas: a Clinical Application Study Recruiting NCT02941302 Not Applicable
12 Oxidoreductive Balance and Lysosomal Activity in Cancer Patients. Recruiting NCT03470857
13 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
14 A Family Study of Adults With Glioma Completed NCT00339352
15 Sedatives' Effects on Neurological Function in Patients With Eloquent Area Glioma Completed NCT02439164 Not Applicable Midazolam

Search NIH Clinical Center for Brain Glioma

Genetic Tests for Brain Glioma

Genetic tests related to Brain Glioma:

# Genetic test Affiliating Genes
1 Glioma of Brain 30

Anatomical Context for Brain Glioma

MalaCards organs/tissues related to Brain Glioma:

42
Brain, Bone, T Cells, Endothelial, Testes, Prostate, Bone Marrow

Publications for Brain Glioma

Articles related to Brain Glioma:

(show top 50) (show all 240)
# Title Authors Year
1
Suppression of Angiotensin-(1-7) on the Disruption of Blood-Brain Barrier in Rat of Brain Glioma. ( 30229380 )
2019
2
Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples. ( 30755240 )
2019
3
Enhancing Boron Uptake in Brain Glioma by a Boron-Polymer/Microbubble Complex with Focused Ultrasound. ( 30883079 )
2019
4
The treatment effects and the underlying mechanism of B cell translocation gene 1 on the oncogenesis of brain glioma. ( 30916818 )
2019
5
Prevalence of human immunodeficiency virus infection in brain glioma patients: Is the virus protective from gliomas? ( 29930869 )
2018
6
Expression of Prostate-Specific Membrane Antigen (PSMA) in Brain Glioma and its Correlation with Tumor Grade. ( 29731795 )
2018
7
Significance of nuclear magnetic resonance combined with Ki-67 and VEGF detection in the diagnosis and prognosis evaluation of brain glioma. ( 29745085 )
2018
8
Comparative toxicity and contrast enhancing assessments of Gd<sub>2</sub>O<sub>3</sub>@BSA and MnO<sub>2</sub>@BSA nanoparticles for MR imaging of brain glioma. ( 29580992 )
2018
9
MnO nanoparticles with unique excitation-dependent fluorescence for multicolor cellular imaging and MR imaging of brain glioma. ( 29610993 )
2018
10
The delicate equilibrium between oxidants and antioxidants in brain glioma. ( 29512467 )
2018
11
USE OF PERFUSION MRI FOR DETERMINATION OF IRRADIATION VOLUMES IN RADIOTHERAPY OF PATIENTS WITH BRAIN GLIOMA. ( 29905541 )
2018
12
Evaluation of D-isomers of 4-borono-2-<sup>18</sup>F-fluoro-phenylalanine and O-<sup>11</sup>C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma. ( 29900520 )
2018
13
Can dynamic contrast-enhanced MRI evaluate VEGF expression in brain glioma? An MRI-guided stereotactic biopsy study. ( 29752976 )
2018
14
Development of functional docetaxel nanomicelles for treatment of brain glioma. ( 29519164 )
2018
15
CREB3L1 and PTN expressions correlate with prognosis of brain glioma patients. ( 29531016 )
2018
16
Genetic and clinical characterization of B7-H3 (CD276) expression and epigenetic regulation in diffuse brain glioma. ( 30027617 )
2018
17
PLK1 inhibitor facilitates the suppressing effect of temozolomide on human brain glioma stem cells. ( 30133120 )
2018
18
Association between IDH1/2 mutations and brain glioma grade. ( 30250611 )
2018
19
Dual-modified cationic liposomes loaded with paclitaxel and survivin siRNA for targeted imaging and therapy of cancer stem cells in brain glioma. ( 30269613 )
2018
20
Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma. ( 30299160 )
2018
21
Effects of Enhancer of Zeste Homolog 2 (EZH2) Expression on Brain Glioma Cell Proliferation and Tumorigenesis. ( 30305602 )
2018
22
Peptide-functionalized and high drug loaded novel nanoparticles as dual-targeting drug delivery system for modulated and controlled release of paclitaxel to brain glioma. ( 30321641 )
2018
23
Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment-Toward the "Perfect Surgery"? ( 30373168 )
2018
24
Highly Sensitive MoS2-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site. ( 30393697 )
2018
25
New Hope in Brain Glioma Surgery: The Role of Intraoperative Ultrasound. A Review. ( 30463249 )
2018
26
Ultra-small but ultra-effective: Folic acid-targeted gold nanoclusters for enhancement of intracranial glioma tumors' radiation therapy efficacy. ( 30594659 )
2018
27
Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes. ( 29588587 )
2018
28
Physical and Psychological Rehabilitation of Patients with Intracranial Glioma. ( 29393188 )
2018
29
Palliative and Supportive Care of Patients with Intracranial Glioma. ( 29393189 )
2018
30
Association of magnetic resonance imaging-based preoperative tumor volume with postsurgical survival time in dogs with primary intracranial glioma. ( 29244602 )
2018
31
Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model. ( 28409734 )
2018
32
Pyrrolidine dithiocarbamate sensitizes U251 brain glioma cells to temozolomide via downregulation of<i>MGMT</i>and<i>BCL-XL</i>. ( 29098021 )
2017
33
Ectopic High Expression of E2-EPF Ubiquitin Carrier Protein Indicates a More Unfavorable Prognosis in Brain Glioma. ( 28384045 )
2017
34
Anaesthetic management for awake craniotomy in brain glioma resection: initial experience in Military Hospital Mohamed V of Rabat. ( 28904684 )
2017
35
Antitumor efficacy of Lf modified daunorubicin plus honokiol liposomes in treatment of brain glioma. ( 28583810 )
2017
36
2-Hydroxyglutarate Detection by Short Echo Time Magnetic Resonance Spectroscopy in Routine Imaging Study of Brain Glioma at 3.0 T. ( 29287025 )
2017
37
The Unwanted Cell Migration in the Brain: Glioma Metastasis. ( 28478595 )
2017
38
Lactoferrin-coated polysaccharide nanoparticles based on chitosan hydrochloride/hyaluronic acid/PEG for treating brain glioma. ( 27987946 )
2017
39
Development of a novel imaging agent using peptide-coated gold nanoparticles toward brain glioma stem cell marker CD133. ( 27721007 )
2017
40
Experimental study of a novel tumstatin on C6 brain glioma in vitro. ( 28928823 )
2017
41
Synergistic regulatory effects of microRNAs on brain glioma cells. ( 29067452 )
2017
42
The efficacy of RGD modified liposomes loaded with vinorelbine plus tetrandrine in treating resistant brain glioma. ( 29166813 )
2017
43
C-type natriuretic peptide-modified lipid vesicles: fabrication and use for the treatment of brain glioma. ( 28402948 )
2017
44
Cerebral schistosomiasis: diffusion-weighted imaging helps to differentiate from brain glioma and metastasis. ( 28090792 )
2017
45
Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells. ( 28615716 )
2017
46
The long non-coding RNA TP73-AS1 interacted with miR-142 to modulate brain glioma growth through HMGB1/RAGE pathway. ( 28379612 )
2017
47
Evaluation of Magnetonanoparticles Conjugated with New Angiogenesis Peptides in Intracranial Glioma Tumors by MRI. ( 28281182 )
2017
48
c(RGDyK)-decorated Pluronic micelles for enhanced doxorubicin and paclitaxel delivery to brain glioma. ( 27143884 )
2016
49
Slit2 and Robo1 expression as biomarkers for assessing prognosis in brain glioma patients. ( 27916173 )
2016
50
GFAP expression is regulated by Pax3 in brain glioma stem cells. ( 27432276 )
2016

Variations for Brain Glioma

Expression for Brain Glioma

Search GEO for disease gene expression data for Brain Glioma.

Pathways for Brain Glioma

GO Terms for Brain Glioma

Biological processes related to Brain Glioma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.78 FASLG NOTCH1 SLIT2 TP53
2 negative regulation of cell migration GO:0030336 9.69 KANK1 ROBO1 SLIT2
3 cell migration involved in sprouting angiogenesis GO:0002042 9.52 ROBO1 SLIT2
4 ventricular septum morphogenesis GO:0060412 9.5 NOTCH1 ROBO1 SLIT2
5 negative regulation of actin filament polymerization GO:0030837 9.49 KANK1 SLIT2
6 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990440 9.46 CREB3L1 TP53
7 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.43 EGFR TP53
8 Roundabout signaling pathway GO:0035385 9.4 ROBO1 SLIT2
9 negative regulation of chemokine-mediated signaling pathway GO:0070100 9.37 ROBO1 SLIT2
10 aortic valve morphogenesis GO:0003180 9.33 NOTCH1 ROBO1 SLIT2
11 chemorepulsion involved in postnatal olfactory bulb interneuron migration GO:0021836 9.26 ROBO1 SLIT2
12 multicellular organism development GO:0007275 9.23 CREB3L1 EGFR NES NOTCH1 PAX3 ROBO1
13 pulmonary valve morphogenesis GO:0003184 9.13 NOTCH1 ROBO1 SLIT2

Molecular functions related to Brain Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 8.92 CREB3L1 EGFR NOTCH1 TP53

Sources for Brain Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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