MCID: BRN032
MIFTS: 44

Brain Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Glioma

MalaCards integrated aliases for Brain Glioma:

Name: Brain Glioma 12 15
Intracranial Glioma 73
Lower Grade Glioma 12
Glioma of Brain 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0060108
UMLS 73 C3665419

Summaries for Brain Glioma

Disease Ontology : 12 A brain cancer that has material basis in glial cells.

MalaCards based summary : Brain Glioma, also known as intracranial glioma, is related to brain ependymoma and glioma susceptibility 1. An important gene associated with Brain Glioma is TP73-AS1 (TP73 Antisense RNA 1), and among its related pathways/superpathways are Glioblastoma Multiforme and Central carbon metabolism in cancer. The drugs Cobalt and Carmustine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related phenotypes are digestive/alimentary and endocrine/exocrine gland

Related Diseases for Brain Glioma

Diseases related to Brain Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 brain ependymoma 31.9 EGFR TP53
2 glioma susceptibility 1 31.9 GFAP IDH1 TP53
3 glioma 31.2 EGFR IDH1 TP53 TP73-AS1
4 glioblastoma 29.8 EGFR IDH1 MGMT TP53 TP73-AS1
5 glioblastoma multiforme 29.7 EGFR GFAP IDH1 MGMT NES TP53
6 brain glioblastoma multiforme 11.0
7 brain oligodendroglioma 11.0
8 frontal convexity meningioma 10.3 GFAP TP53
9 gliofibroma 10.3 GFAP TP53
10 oligoastrocytoma 10.3 GFAP MGMT
11 cerebral convexity meningioma 10.3 GFAP TP53
12 cellular ependymoma 10.3 GFAP TP53
13 protoplasmic astrocytoma 10.3 GFAP TP53
14 meninges sarcoma 10.3 GFAP TP53
15 cerebral neuroblastoma 10.3 GFAP TP53
16 spinal cancer 10.3 GFAP TP53
17 cerebral ventricle cancer 10.2 GFAP TP53
18 chordoid glioma 10.2 GFAP TP53
19 breast squamous cell carcinoma 10.2 EGFR TP53
20 malignant ependymoma 10.2 GFAP TP53
21 anaplastic ganglioglioma 10.2 GFAP NES
22 benign glioma 10.2 GFAP TP53
23 brain stem cancer 10.2 NES TP53
24 central nervous system germ cell tumor 10.2 GFAP NES
25 microglandular adenosis 10.2 EGFR TP53
26 pleomorphic carcinoma 10.2 EGFR TP53
27 astroblastoma 10.2 GFAP NES
28 pulmonary blastoma 10.2 EGFR TP53
29 medulloepithelioma 10.2 GFAP NES
30 subependymoma 10.2 GFAP NES
31 papilloma of choroid plexus 10.2 GFAP TP53
32 soft tissue sarcoma 10.2 EGFR TP53
33 tanycytic ependymoma 10.2 GFAP NES
34 intracranial chondrosarcoma 10.2 IDH1 TP53
35 papillary ependymoma 10.2 GFAP NES
36 cerebellar astrocytoma 10.2 IDH1 TP53
37 choroid plexus cancer 10.2 GFAP TP53
38 anaplastic oligodendroglioma 10.2 EGFR GFAP MGMT
39 extraventricular neurocytoma 10.2 GFAP IDH1
40 central nervous system primitive neuroectodermal neoplasm 10.2 GFAP NES TP53
41 ependymoblastoma 10.2 GFAP NES TP53
42 lynch syndrome 10.2 EGFR MGMT TP53
43 optic nerve glioma 10.1 GFAP NES TP53
44 ganglioglioma 10.1 GFAP NES TP53
45 brain ischemia 10.1 GFAP NES
46 esophageal basaloid squamous cell carcinoma 10.1 EGFR TP53
47 gallbladder cancer 10.1 EGFR MGMT TP53
48 teratoma 10.1 GFAP NES TP53
49 central neurocytoma 10.1 GFAP NES
50 angiocentric glioma 10.1 GFAP IDH1

Graphical network of the top 20 diseases related to Brain Glioma:



Diseases related to Brain Glioma

Symptoms & Phenotypes for Brain Glioma

MGI Mouse Phenotypes related to Brain Glioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.87 EGFR FASLG GFAP PAX3 ROBO1 SLIT2
2 endocrine/exocrine gland MP:0005379 9.8 EGFR FASLG MGMT PAX3 ROBO1 SLIT2
3 neoplasm MP:0002006 9.63 EGFR FASLG MGMT PAX3 ROBO1 TP53
4 renal/urinary system MP:0005367 9.43 EGFR FASLG PAX3 ROBO1 SLIT2 TP53
5 respiratory system MP:0005388 9.17 EGFR FASLG IDH1 MGMT PAX3 ROBO1

Drugs & Therapeutics for Brain Glioma

Drugs for Brain Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cobalt Approved, Experimental Phase 3 7440-48-4 104729
2
Carmustine Approved, Investigational Phase 3 154-93-8 2578
3
Dopamine Approved Phase 3,Phase 1 51-61-6, 62-31-7 681
4 Mitolactol Investigational Phase 3 10318-26-0
5 Alkylating Agents Phase 3,Phase 1
6 Antineoplastic Agents, Alkylating Phase 3,Phase 1
7 Neurotransmitter Agents Phase 3,Phase 1,Not Applicable
8 Dopamine Agents Phase 3,Phase 1
9 Dihydroxyphenylalanine Phase 3,Phase 1
10
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
11
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
12
Olaparib Approved Phase 2 763113-22-0 23725625
13 Angiogenesis Inhibitors Phase 1, Phase 2
14 Angiogenesis Modulating Agents Phase 1, Phase 2
15 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
16
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
17
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166
18
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
19
Flumazenil Approved Not Applicable 78755-81-4 3373
20
Dexmedetomidine Approved, Vet_approved Not Applicable 113775-47-6 68602 5311068
21
Midazolam Approved, Illicit Not Applicable 59467-70-8 4192
22
Dinoprost Tromethamine Approved, Vet_approved 38562-01-5 5282415
23
Tocopherol Approved, Investigational 1406-66-2 14986
24
Dinoprost Approved, Investigational 551-11-1 5283078
25
Vitamin A Approved, Nutraceutical, Vet_approved 11103-57-4, 68-26-8 445354
26
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
27 Tocotrienol Investigational 6829-55-6
28 Adjuvants, Anesthesia Not Applicable
29 Psychotropic Drugs Not Applicable
30 GABA Modulators Not Applicable
31 Central Nervous System Depressants Not Applicable
32 Anesthetics Not Applicable
33 Hypnotics and Sedatives Not Applicable
34 Tranquilizing Agents Not Applicable
35 Anesthetics, Intravenous Not Applicable
36 Anti-Anxiety Agents Not Applicable
37 Anesthetics, General Not Applicable
38 GABA Agents Not Applicable
39 Tocopherols
40 Protein C Inhibitor
41 Vitamins
42 Alpha 1-Antitrypsin
43 Retinol palmitate
44 Tocotrienols
45 retinol
46 Antioxidants
47 Catalase
48 Fluorodeoxyglucose F18
49 8-epi-prostaglandin F2alpha

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Radiation Therapy in Treating Patients With Brain Cancer Completed NCT00002620 Phase 3 carmustine;chemotherapy;mitolactol
2 18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety Recruiting NCT03042416 Phase 3 18F-DOPA
3 C11-Sodium Acetate PET/CT Imaging Evaluation in Brain Glioma, Post Therapy Necrosis and Pseudo-progression Withdrawn NCT01961934 Phase 2, Phase 3 Sodium Acetate C11 PET/CT Imaging
4 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Recruiting NCT01884740 Phase 1, Phase 2 SIACI of Erbitux and Bevacizumab
5 Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations Recruiting NCT03212274 Phase 2 Olaparib
6 Temozolomide Chronotherapy for High Grade Glioma Recruiting NCT02781792 Phase 1 Temozolomide
7 FDOPA-PET/MRI for the Pre-operative Evaluation of Gliomas Terminated NCT02371031 Phase 1 6-[F-18]-Fluoro-L-3,4,-dihydroxyphenylalanine
8 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
9 A Family Study of Adults With Glioma Completed NCT00339352
10 Sedatives' Effects on Neurological Function in Patients With Eloquent Area Glioma Completed NCT02439164 Not Applicable Midazolam
11 Brain Glioma Registry Combining Clinical and Imaging Information Recruiting NCT02619890
12 Multimodality Imaging Combined With Multiple Targets Pathological Examination for Detecting of Biological Borders of Gliomas: a Clinical Application Study Recruiting NCT02941302 Not Applicable
13 Oxidoreductive Balance and Lysosomal Activity in Cancer Patients. Recruiting NCT03470857
14 Awake vs. Asleep Craniotomy for Non-eloquent Gliomas Not yet recruiting NCT03621748 Not Applicable
15 Image Guided Therapy in the Treatment of Gliomas Terminated NCT01263821 Not Applicable

Search NIH Clinical Center for Brain Glioma

Genetic Tests for Brain Glioma

Genetic tests related to Brain Glioma:

# Genetic test Affiliating Genes
1 Glioma of Brain 29

Anatomical Context for Brain Glioma

MalaCards organs/tissues related to Brain Glioma:

41
Brain, Bone, Bone Marrow, Lung, Skin, Spinal Cord, Pancreas

Publications for Brain Glioma

Articles related to Brain Glioma:

(show top 50) (show all 237)
# Title Authors Year
1
Prevalence of human immunodeficiency virus infection in brain glioma patients: Is the virus protective from gliomas? ( 29930869 )
2018
2
Expression of Prostate-Specific Membrane Antigen (PSMA) in Brain Glioma and its Correlation with Tumor Grade. ( 29731795 )
2018
3
Significance of nuclear magnetic resonance combined with Ki-67 and VEGF detection in the diagnosis and prognosis evaluation of brain glioma. ( 29745085 )
2018
4
Comparative toxicity and contrast enhancing assessments of Gd<sub>2</sub>O<sub>3</sub>@BSA and MnO<sub>2</sub>@BSA nanoparticles for MR imaging of brain glioma. ( 29580992 )
2018
5
MnO nanoparticles with unique excitation-dependent fluorescence for multicolor cellular imaging and MR imaging of brain glioma. ( 29610993 )
2018
6
The delicate equilibrium between oxidants and antioxidants in brain glioma. ( 29512467 )
2018
7
USE OF PERFUSION MRI FOR DETERMINATION OF IRRADIATION VOLUMES IN RADIOTHERAPY OF PATIENTS WITH BRAIN GLIOMA. ( 29905541 )
2018
8
Evaluation of D-isomers of 4-borono-2-<sup>18</sup>F-fluoro-phenylalanine and O-<sup>11</sup>C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma. ( 29900520 )
2018
9
Can dynamic contrast-enhanced MRI evaluate VEGF expression in brain glioma? An MRI-guided stereotactic biopsy study. ( 29752976 )
2018
10
Development of functional docetaxel nanomicelles for treatment of brain glioma. ( 29519164 )
2018
11
CREB3L1 and PTN expressions correlate with prognosis of brain glioma patients. ( 29531016 )
2018
12
The Long Non-Coding RNA TP73-AS1 Interacted With miR-142 to Modulate Brain Glioma Growth Through HMGB1/RAGE Pathway. ( 28379612 )
2018
13
Genetic and clinical characterization of B7-H3 (CD276) expression and epigenetic regulation in diffuse brain glioma. ( 30027617 )
2018
14
PLK1 inhibitor facilitates the suppressing effect of temozolomide on human brain glioma stem cells. ( 30133120 )
2018
15
Suppression of Angiotensin-(1-7) on the Disruption of Blood-Brain Barrier in Rat of Brain Glioma. ( 30229380 )
2018
16
Association between IDH1/2 mutations and brain glioma grade. ( 30250611 )
2018
17
Dual-modified cationic liposomes loaded with paclitaxel and survivin siRNA for targeted imaging and therapy of cancer stem cells in brain glioma. ( 30269613 )
2018
18
Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma. ( 30299160 )
2018
19
Effects of Enhancer of Zeste Homolog 2 (EZH2) Expression on Brain Glioma Cell Proliferation and Tumorigenesis. ( 30305602 )
2018
20
Peptide-functionalized and high drug loaded novel nanoparticles as dual-targeting drug delivery system for modulated and controlled release of paclitaxel to brain glioma. ( 30321641 )
2018
21
Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment-Toward the "Perfect Surgery"? ( 30373168 )
2018
22
Highly Sensitive MoS2-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site. ( 30393697 )
2018
23
New Hope in Brain Glioma Surgery: The Role of Intraoperative Ultrasound. A Review. ( 30463249 )
2018
24
Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model. ( 28409734 )
2018
25
Association of magnetic resonance imaging-based preoperative tumor volume with postsurgical survival time in dogs with primary intracranial glioma. ( 29244602 )
2018
26
Physical and Psychological Rehabilitation of Patients with Intracranial Glioma. ( 29393188 )
2018
27
Palliative and Supportive Care of Patients with Intracranial Glioma. ( 29393189 )
2018
28
Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes. ( 29588587 )
2018
29
Pyrrolidine dithiocarbamate sensitizes U251 brain glioma cells to temozolomide via downregulation of<i>MGMT</i>and<i>BCL-XL</i>. ( 29098021 )
2017
30
Ectopic High Expression of E2-EPF Ubiquitin Carrier Protein Indicates a More Unfavorable Prognosis in Brain Glioma. ( 28384045 )
2017
31
Anaesthetic management for awake craniotomy in brain glioma resection: initial experience in Military Hospital Mohamed V of Rabat. ( 28904684 )
2017
32
Antitumor efficacy of Lf modified daunorubicin plus honokiol liposomes in treatment of brain glioma. ( 28583810 )
2017
33
2-Hydroxyglutarate Detection by Short Echo Time Magnetic Resonance Spectroscopy in Routine Imaging Study of Brain Glioma at 3.0 T. ( 29287025 )
2017
34
The Unwanted Cell Migration in the Brain: Glioma Metastasis. ( 28478595 )
2017
35
Lactoferrin-coated polysaccharide nanoparticles based on chitosan hydrochloride/hyaluronic acid/PEG for treating brain glioma. ( 27987946 )
2017
36
Development of a novel imaging agent using peptide-coated gold nanoparticles toward brain glioma stem cell marker CD133. ( 27721007 )
2017
37
Experimental study of a novel tumstatin on C6 brain glioma in vitro. ( 28928823 )
2017
38
Synergistic regulatory effects of microRNAs on brain glioma cells. ( 29067452 )
2017
39
The efficacy of RGD modified liposomes loaded with vinorelbine plus tetrandrine in treating resistant brain glioma. ( 29166813 )
2017
40
C-type natriuretic peptide-modified lipid vesicles: fabrication and use for the treatment of brain glioma. ( 28402948 )
2017
41
Cerebral schistosomiasis: diffusion-weighted imaging helps to differentiate from brain glioma and metastasis. ( 28090792 )
2017
42
Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells. ( 28615716 )
2017
43
Evaluation of Magnetonanoparticles Conjugated with New Angiogenesis Peptides in Intracranial Glioma Tumors by MRI. ( 28281182 )
2017
44
c(RGDyK)-decorated Pluronic micelles for enhanced doxorubicin and paclitaxel delivery to brain glioma. ( 27143884 )
2016
45
Slit2 and Robo1 expression as biomarkers for assessing prognosis in brain glioma patients. ( 27916173 )
2016
46
GFAP expression is regulated by Pax3 in brain glioma stem cells. ( 27432276 )
2016
47
Synergistic Combination of Doxorubicin and Paclitaxel Delivered by Blood Brain Barrier and Glioma Cells Dual Targeting Liposomes for Chemotherapy of Brain Glioma. ( 27033513 )
2016
48
IVIM perfusion fraction is prognostic for survival in brain glioma. ( 27116215 )
2016
49
Destruction of vasculogenic mimicry channels by targeting epirubicin plus celecoxib liposomes in treatment of brain glioma. ( 27042063 )
2016
50
Conjugation Magnetic PAEEP-PLLA Nanoparticles with Lactoferrin as a Specific Targeting MRI Contrast Agent for Detection of Brain Glioma in Rats. ( 27119155 )
2016

Variations for Brain Glioma

Expression for Brain Glioma

Search GEO for disease gene expression data for Brain Glioma.

Pathways for Brain Glioma

Pathways related to Brain Glioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.48 EGFR MGMT TP53
2 11.14 EGFR IDH1 TP53
3 11 EGFR GFAP SLIT2 TP53
4 10.84 EGFR FASLG TP53

GO Terms for Brain Glioma

Biological processes related to Brain Glioma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.8 EGFR NES PAX3 ROBO1 SLIT2 TP53
2 negative regulation of cell migration GO:0030336 9.63 KANK1 ROBO1 SLIT2
3 response to organic cyclic compound GO:0014070 9.61 EGFR IDH1 MGMT
4 aortic valve morphogenesis GO:0003180 9.49 ROBO1 SLIT2
5 cell migration involved in sprouting angiogenesis GO:0002042 9.48 ROBO1 SLIT2
6 negative regulation of actin filament polymerization GO:0030837 9.4 KANK1 SLIT2
7 pulmonary valve morphogenesis GO:0003184 9.37 ROBO1 SLIT2
8 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.26 EGFR TP53
9 Roundabout signaling pathway GO:0035385 9.16 ROBO1 SLIT2
10 negative regulation of chemokine-mediated signaling pathway GO:0070100 8.96 ROBO1 SLIT2
11 chemorepulsion involved in postnatal olfactory bulb interneuron migration GO:0021836 8.62 ROBO1 SLIT2

Molecular functions related to Brain Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.1 EGFR GFAP IDH1 ROBO1 SLIT2 TP53

Sources for Brain Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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