MCID: BRN032
MIFTS: 45

Brain Glioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Glioma

MalaCards integrated aliases for Brain Glioma:

Name: Brain Glioma 12 15
Intracranial Glioma 74
Lower Grade Glioma 12
Glioma of Brain 30

Classifications:



External Ids:

Disease Ontology 12 DOID:0060108
UMLS 74 C3665419

Summaries for Brain Glioma

Disease Ontology : 12 A brain cancer that has material basis in glial cells.

MalaCards based summary : Brain Glioma, also known as intracranial glioma, is related to glioma susceptibility 1 and brain ependymoma. An important gene associated with Brain Glioma is TP73-AS1 (TP73 Antisense RNA 1), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Glioblastoma Multiforme. The drugs Cobalt and Carmustine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and t cells, and related phenotypes are cellular and cardiovascular system

Related Diseases for Brain Glioma

Diseases related to Brain Glioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 glioma susceptibility 1 32.3 GFAP TP53
2 brain ependymoma 32.2 EGFR TP53
3 glioblastoma 30.4 EGFR MGMT TP53 TP73-AS1
4 glioblastoma multiforme 30.1 EGFR GFAP MGMT NES TP53
5 hydrocephalus 29.3 GFAP NES TP53
6 brain glioblastoma multiforme 11.0
7 brain oligodendroglioma 11.0
8 glioma 10.9
9 frontal convexity meningioma 10.4 GFAP TP53
10 gliofibroma 10.4 GFAP TP53
11 cerebral convexity meningioma 10.4 GFAP TP53
12 oligoastrocytoma 10.4 GFAP MGMT
13 cellular ependymoma 10.4 GFAP TP53
14 protoplasmic astrocytoma 10.4 GFAP TP53
15 meninges sarcoma 10.4 GFAP TP53
16 cerebral neuroblastoma 10.4 GFAP TP53
17 mixed glioma 10.4 GFAP TP53
18 recurrent respiratory papillomatosis 10.4 EGFR TP53
19 anaplastic ganglioglioma 10.4 GFAP NES
20 spinal cancer 10.4 GFAP TP53
21 central nervous system germ cell tumor 10.4 GFAP NES
22 cerebral ventricle cancer 10.3 GFAP TP53
23 dysembryoplastic neuroepithelial tumor 10.3 GFAP NES
24 breast squamous cell carcinoma 10.3 EGFR TP53
25 chordoid glioma 10.3 GFAP TP53
26 brain stem cancer 10.3 NES TP53
27 astroblastoma 10.3 GFAP NES
28 splenic diffuse red pulp small b-cell lymphoma 10.3 NOTCH1 TP53
29 invasive bladder transitional cell carcinoma 10.3 NOTCH1 TP53
30 malignant ependymoma 10.3 GFAP TP53
31 fibrillary astrocytoma 10.3 GFAP MGMT TP53
32 pleomorphic xanthoastrocytoma 10.3 GFAP MGMT TP53
33 medulloepithelioma 10.3 GFAP NES
34 microglandular adenosis 10.3 EGFR TP53
35 anaplastic oligodendroglioma 10.3 EGFR GFAP MGMT
36 central nervous system primitive neuroectodermal neoplasm 10.3 GFAP NES TP53
37 ependymoblastoma 10.3 GFAP NES TP53
38 optic nerve glioma 10.3 GFAP NES TP53
39 infratentorial cancer 10.3 GFAP NES TP53
40 ganglioglioma 10.3 GFAP NES TP53
41 subependymoma 10.2 GFAP NES
42 pleomorphic carcinoma 10.2 EGFR TP53
43 teratoma 10.2 GFAP NES TP53
44 pulmonary blastoma 10.2 EGFR TP53
45 lynch syndrome 10.2 EGFR MGMT TP53
46 nervous system disease 10.2 GFAP NES TP53
47 chronic venous leg ulcers 10.2 FASLG TP53
48 gallbladder cancer 10.2 EGFR MGMT TP53
49 tanycytic ependymoma 10.2 GFAP NES
50 gastrointestinal stromal tumor 10.1 EGFR NES TP53

Graphical network of the top 20 diseases related to Brain Glioma:



Diseases related to Brain Glioma

Symptoms & Phenotypes for Brain Glioma

MGI Mouse Phenotypes related to Brain Glioma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.09 CREB3L1 EGFR FASLG GFAP NOTCH1 PAX3
2 cardiovascular system MP:0005385 10.06 EGFR FASLG GFAP NOTCH1 PAX3 ROBO1
3 digestive/alimentary MP:0005381 10.01 EGFR FASLG GFAP NOTCH1 PAX3 ROBO1
4 endocrine/exocrine gland MP:0005379 9.97 EGFR FASLG MGMT NOTCH1 PAX3 ROBO1
5 integument MP:0010771 9.87 EGFR FASLG NOTCH1 PAX3 ROBO1 SLIT2
6 neoplasm MP:0002006 9.8 EGFR FASLG MGMT NOTCH1 PAX3 ROBO1
7 normal MP:0002873 9.7 EGFR FASLG GFAP NOTCH1 PAX3 ROBO1
8 renal/urinary system MP:0005367 9.5 EGFR FASLG NOTCH1 PAX3 ROBO1 SLIT2
9 respiratory system MP:0005388 9.17 EGFR FASLG MGMT NOTCH1 PAX3 ROBO1

Drugs & Therapeutics for Brain Glioma

Drugs for Brain Glioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 49)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cobalt Approved, Experimental Phase 3 7440-48-4 104729
2
Carmustine Approved, Investigational Phase 3 154-93-8 2578
3
Dopamine Approved Phase 3,Phase 1 62-31-7, 51-61-6 681
4 Mitolactol Investigational Phase 3 10318-26-0
5 Alkylating Agents Phase 3,Phase 1
6 Antineoplastic Agents, Alkylating Phase 3,Phase 1
7 Neurotransmitter Agents Phase 3,Phase 1,Not Applicable
8 Dopamine Agents Phase 3,Phase 1
9 Dihydroxyphenylalanine Phase 3,Phase 1
10
Bevacizumab Approved, Investigational Phase 1, Phase 2 216974-75-3
11
Cetuximab Approved Phase 1, Phase 2 205923-56-4 56842117 2333
12
Olaparib Approved Phase 2 763113-22-0 23725625
13 Angiogenesis Inhibitors Phase 1, Phase 2
14 Antineoplastic Agents, Immunological Phase 1, Phase 2
15 Angiogenesis Modulating Agents Phase 1, Phase 2
16 Poly(ADP-ribose) Polymerase Inhibitors Phase 2
17
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
18
Flumazenil Approved Not Applicable 78755-81-4 3373
19
Dexmedetomidine Approved, Vet_approved Not Applicable 113775-47-6 5311068 68602
20
Midazolam Approved, Illicit Not Applicable 59467-70-8 4192
21
Propofol Approved, Investigational, Vet_approved Not Applicable 2078-54-8 4943
22
Dinoprost tromethamine Approved, Vet_approved 38562-01-5 5282415
23
Dinoprost Approved, Investigational 551-11-1 5283078
24
Tocopherol Approved, Investigational 1406-66-2 14986
25
Vitamin E Approved, Nutraceutical, Vet_approved 59-02-9 14985
26
Vitamin A Approved, Nutraceutical, Vet_approved 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
27 Tocotrienol Investigational 6829-55-6
28 GABA Agents Not Applicable
29 Anti-Anxiety Agents Not Applicable
30 Tranquilizing Agents Not Applicable
31 GABA Modulators Not Applicable
32 Central Nervous System Depressants Not Applicable
33 Anesthetics, General Not Applicable
34 Anesthetics Not Applicable
35 Anesthetics, Intravenous Not Applicable
36 Adjuvants, Anesthesia Not Applicable
37 Hypnotics and Sedatives Not Applicable
38 Psychotropic Drugs Not Applicable
39 Catalase
40 Retinol palmitate
41 Protein C Inhibitor
42 Antioxidants
43 Fluorodeoxyglucose F18
44 Tocopherols
45 8-epi-prostaglandin F2alpha
46 retinol
47 Tocotrienols
48 Vitamins
49 Alpha 1-Antitrypsin

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 Radiation Therapy in Treating Patients With Brain Cancer Completed NCT00002620 Phase 3 carmustine;chemotherapy;mitolactol
2 18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety Recruiting NCT03042416 Phase 3 18F-DOPA
3 C11-Sodium Acetate PET/CT Imaging Evaluation in Brain Glioma, Post Therapy Necrosis and Pseudo-progression Withdrawn NCT01961934 Phase 2, Phase 3 Sodium Acetate C11 PET/CT Imaging
4 Intraarterial Infusion Of Erbitux and Bevacizumab For Relapsed/Refractory Intracranial Glioma In Patients Under 22 Recruiting NCT01884740 Phase 1, Phase 2 SIACI of Erbitux and Bevacizumab
5 Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations Recruiting NCT03212274 Phase 2 Olaparib
6 Temozolomide Chronotherapy for High Grade Glioma Recruiting NCT02781792 Phase 1 Temozolomide
7 FDOPA-PET/MRI for the Pre-operative Evaluation of Gliomas Terminated NCT02371031 Phase 1 6-[F-18]-Fluoro-L-3,4,-dihydroxyphenylalanine
8 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
9 A Family Study of Adults With Glioma Completed NCT00339352
10 Sedatives' Effects on Neurological Function in Patients With Eloquent Area Glioma Completed NCT02439164 Not Applicable Midazolam
11 Brain Glioma Registry Combining Clinical and Imaging Information Recruiting NCT02619890
12 Multimodality Imaging Combined With Multiple Targets Pathological Examination for Detecting of Biological Borders of Gliomas: a Clinical Application Study Recruiting NCT02941302 Not Applicable
13 Oxidoreductive Balance and Lysosomal Activity in Cancer Patients. Recruiting NCT03470857
14 Awake vs. Asleep Craniotomy for Non-eloquent Gliomas Not yet recruiting NCT03621748 Not Applicable
15 Image Guided Therapy in the Treatment of Gliomas Terminated NCT01263821 Not Applicable

Search NIH Clinical Center for Brain Glioma

Genetic Tests for Brain Glioma

Genetic tests related to Brain Glioma:

# Genetic test Affiliating Genes
1 Glioma of Brain 30

Anatomical Context for Brain Glioma

MalaCards organs/tissues related to Brain Glioma:

42
Brain, Bone, T Cells, Endothelial, Testes, Prostate, Bone Marrow

Publications for Brain Glioma

Articles related to Brain Glioma:

(show top 50) (show all 255)
# Title Authors Year
1
Slowdown intracranial glioma progression by optical hyperthermia therapy: study on a CT-2A mouse astrocytoma model. ( 31082814 )
2019
2
The Delicate Equilibrium between Oxidants and Antioxidants in Brain Glioma. ( 29512467 )
2019
3
Can dynamic contrast-enhanced MRI evaluate VEGF expression in brain glioma? An MRI-guided stereotactic biopsy study. ( 29752976 )
2019
4
Suppression of Angiotensin-(1-7) on the Disruption of Blood-Brain Barrier in Rat of Brain Glioma. ( 30229380 )
2019
5
Correlation of alteration of HLA-F expression and clinical characterization in 593 brain glioma samples. ( 30755240 )
2019
6
Enhancing Boron Uptake in Brain Glioma by a Boron-Polymer/Microbubble Complex with Focused Ultrasound. ( 30883079 )
2019
7
The treatment effects and the underlying mechanism of B cell translocation gene 1 on the oncogenesis of brain glioma. ( 30916818 )
2019
8
Anti-proliferative Activities towards Human Brain Glioma U251 Cells and Human Carcinoma Cells (KB3-1) of Some Twin-Drug Type Bivalent C2-Symmetrical Phenylboronic Acid Derivatives. ( 31061327 )
2019
9
Use of Genome-Scale Integrated Analysis to Identify Key Genes and Potential Molecular Mechanisms in Recurrence of Lower-Grade Brain Glioma. ( 31104065 )
2019
10
Triple combination immunotherapy with GVAX, anti-PD-1 monoclonal antibody, and agonist anti-OX40 monoclonal antibody is highly effective against murine intracranial glioma. ( 31069135 )
2019
11
Plant Virus-Like Particle In Situ Vaccine for Intracranial Glioma Immunotherapy. ( 30974896 )
2019
12
Ultra-small but ultra-effective: Folic acid-targeted gold nanoclusters for enhancement of intracranial glioma tumors' radiation therapy efficacy. ( 30594659 )
2019
13
The Long Non-Coding RNA TP73-AS1 Interacted With miR-142 to Modulate Brain Glioma Growth Through HMGB1/RAGE Pathway. ( 28379612 )
2018
14
2-Hydroxyglutarate Detection by Short Echo Time Magnetic Resonance Spectroscopy in Routine Imaging Study of Brain Glioma at 3.0 T. ( 29287025 )
2018
15
Development of functional docetaxel nanomicelles for treatment of brain glioma. ( 29519164 )
2018
16
CREB3L1 and PTN expressions correlate with prognosis of brain glioma patients. ( 29531016 )
2018
17
Comparative toxicity and contrast enhancing assessments of Gd2O3@BSA and MnO2@BSA nanoparticles for MR imaging of brain glioma. ( 29580992 )
2018
18
MnO nanoparticles with unique excitation-dependent fluorescence for multicolor cellular imaging and MR imaging of brain glioma. ( 29610993 )
2018
19
Expression of Prostate-Specific Membrane Antigen (PSMA) in Brain Glioma and its Correlation with Tumor Grade. ( 29731795 )
2018
20
Significance of nuclear magnetic resonance combined with Ki-67 and VEGF detection in the diagnosis and prognosis evaluation of brain glioma. ( 29745085 )
2018
21
Evaluation of D-isomers of 4-borono-2-18F-fluoro-phenylalanine and O-11C-methyl-tyrosine as brain tumor imaging agents: a comparative PET study with their L-isomers in rat brain glioma. ( 29900520 )
2018
22
USE OF PERFUSION MRI FOR DETERMINATION OF IRRADIATION VOLUMES IN RADIOTHERAPY OF PATIENTS WITH BRAIN GLIOMA. ( 29905541 )
2018
23
Prevalence of human immunodeficiency virus infection in brain glioma patients: Is the virus protective from gliomas? ( 29930869 )
2018
24
Genetic and clinical characterization of B7-H3 (CD276) expression and epigenetic regulation in diffuse brain glioma. ( 30027617 )
2018
25
PLK1 inhibitor facilitates the suppressing effect of temozolomide on human brain glioma stem cells. ( 30133120 )
2018
26
Association between IDH1/2 mutations and brain glioma grade. ( 30250611 )
2018
27
Dual-modified cationic liposomes loaded with paclitaxel and survivin siRNA for targeted imaging and therapy of cancer stem cells in brain glioma. ( 30269613 )
2018
28
Vinorelbine cationic liposomes modified with wheat germ agglutinin for inhibiting tumor metastasis in treatment of brain glioma. ( 30299160 )
2018
29
Effects of Enhancer of Zeste Homolog 2 (EZH2) Expression on Brain Glioma Cell Proliferation and Tumorigenesis. ( 30305602 )
2018
30
Peptide-functionalized and high drug loaded novel nanoparticles as dual-targeting drug delivery system for modulated and controlled release of paclitaxel to brain glioma. ( 30321641 )
2018
31
Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment-Toward the "Perfect Surgery"? ( 30373168 )
2018
32
Highly Sensitive MoS2-Indocyanine Green Hybrid for Photoacoustic Imaging of Orthotopic Brain Glioma at Deep Site. ( 30393697 )
2018
33
New Hope in Brain Glioma Surgery: The Role of Intraoperative Ultrasound. A Review. ( 30463249 )
2018
34
Targeted therapy of intracranial glioma model mice with curcumin nanoliposomes. ( 29588587 )
2018
35
Physical and Psychological Rehabilitation of Patients with Intracranial Glioma. ( 29393188 )
2018
36
Palliative and Supportive Care of Patients with Intracranial Glioma. ( 29393189 )
2018
37
Association of magnetic resonance imaging-based preoperative tumor volume with postsurgical survival time in dogs with primary intracranial glioma. ( 29244602 )
2018
38
Intratumoral delivery of bortezomib: impact on survival in an intracranial glioma tumor model. ( 28409734 )
2018
39
IVIM perfusion fraction is prognostic for survival in brain glioma. ( 27116215 )
2017
40
Targeting vincristine plus tetrandrine liposomes modified with DSPE-PEG2000-transferrin in treatment of brain glioma. ( 27644895 )
2017
41
Development of a novel imaging agent using peptide-coated gold nanoparticles toward brain glioma stem cell marker CD133. ( 27721007 )
2017
42
Lactoferrin-coated polysaccharide nanoparticles based on chitosan hydrochloride/hyaluronic acid/PEG for treating brain glioma. ( 27987946 )
2017
43
Cerebral schistosomiasis: diffusion-weighted imaging helps to differentiate from brain glioma and metastasis. ( 28090792 )
2017
44
Ectopic High Expression of E2-EPF Ubiquitin Carrier Protein Indicates a More Unfavorable Prognosis in Brain Glioma. ( 28384045 )
2017
45
C-type natriuretic peptide-modified lipid vesicles: fabrication and use for the treatment of brain glioma. ( 28402948 )
2017
46
The Unwanted Cell Migration in the Brain: Glioma Metastasis. ( 28478595 )
2017
47
Antitumor efficacy of Lf modified daunorubicin plus honokiol liposomes in treatment of brain glioma. ( 28583810 )
2017
48
Lipid vesicles containing transferrin receptor binding peptide TfR-T12 and octa-arginine conjugate stearyl-R8 efficiently treat brain glioma along with glioma stem cells. ( 28615716 )
2017
49
Anaesthetic management for awake craniotomy in brain glioma resection: initial experience in Military Hospital Mohamed V of Rabat. ( 28904684 )
2017
50
Experimental study of a novel tumstatin on C6 brain glioma in vitro. ( 28928823 )
2017

Variations for Brain Glioma

Expression for Brain Glioma

Search GEO for disease gene expression data for Brain Glioma.

Pathways for Brain Glioma

GO Terms for Brain Glioma

Biological processes related to Brain Glioma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of apoptotic process GO:0043065 9.78 FASLG NOTCH1 SLIT2 TP53
2 negative regulation of cell migration GO:0030336 9.69 KANK1 ROBO1 SLIT2
3 cell migration involved in sprouting angiogenesis GO:0002042 9.52 ROBO1 SLIT2
4 ventricular septum morphogenesis GO:0060412 9.5 NOTCH1 ROBO1 SLIT2
5 negative regulation of actin filament polymerization GO:0030837 9.49 KANK1 SLIT2
6 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress GO:1990440 9.46 CREB3L1 TP53
7 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.43 EGFR TP53
8 Roundabout signaling pathway GO:0035385 9.4 ROBO1 SLIT2
9 negative regulation of chemokine-mediated signaling pathway GO:0070100 9.37 ROBO1 SLIT2
10 aortic valve morphogenesis GO:0003180 9.33 NOTCH1 ROBO1 SLIT2
11 chemorepulsion involved in postnatal olfactory bulb interneuron migration GO:0021836 9.26 ROBO1 SLIT2
12 multicellular organism development GO:0007275 9.23 CREB3L1 EGFR NES NOTCH1 PAX3 ROBO1
13 pulmonary valve morphogenesis GO:0003184 9.13 NOTCH1 ROBO1 SLIT2

Molecular functions related to Brain Glioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 8.92 CREB3L1 EGFR NOTCH1 TP53

Sources for Brain Glioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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