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MCID: BRN071
MIFTS: 54

Brain Injury

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Brain Injury

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MalaCards integrated aliases for Brain Injury:

Name: Brain Injury 38 54

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Brain Injury

About this section
NINDS : 54 Traumatic brain injury (TBI), a form of acquired brain injury, occurs when a sudden trauma causes damage to the brain. TBI can result when the head suddenly and violently hits an object, or when an object pierces the skull and enters brain tissue.  Symptoms of a TBI can be mild, moderate, or severe, depending on the extent of the damage to the brain. A person with a mild TBI may remain conscious or may experience a loss of consciousness for a few seconds or minutes. Other symptoms of mild TBI include headache, confusion, lightheadedness, dizziness, blurred vision or tired eyes, ringing in the ears, bad taste in the mouth, fatigue or lethargy, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration, attention, or thinking.  A person with a moderate or severe TBI may show these same symptoms, but may also have a headache that gets worse or does not go away, repeated vomiting or nausea, convulsions or seizures, an inability to awaken from sleep, dilation of one or both pupils of the eyes, slurred speech, weakness or numbness in the extremities, loss of coordination, and increased confusion, restlessness, or agitation.

MalaCards based summary : Brain Injury is related to neonatal hypoxic and ischemic brain injury and head injury. An important gene associated with Brain Injury is ASIC1 (Acid Sensing Ion Channel Subunit 1), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Neuroscience. The drugs Zinc and Morphine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

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Related Diseases for Brain Injury

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Diseases related to Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 438)
# Related Disease Score Top Affiliating Genes
1 neonatal hypoxic and ischemic brain injury 33.9 BDNF ENO2 MBP
2 head injury 32.6 APOE ENO2 S100B
3 periventricular leukomalacia 32.2 EPO IL6 MBP
4 persistent vegetative state 32.2 APOE ENO2
5 traumatic brain injury 32.0 APOE BDNF CASP3 COMT DRD2 ENO2
6 alzheimer disease 31.3 APOE BDNF CASP3 GFAP MAPT S100B
7 aphasia 31.3 APOE BDNF MAPT
8 post-traumatic stress disorder 30.6 APOE BDNF COMT DRD2
9 spinal cord injury 30.4 BDNF CASP3 GFAP IL6
10 status epilepticus 30.2 BDNF CASP3 ENO2 GFAP
11 stroke, ischemic 29.9 APOE CASP3 ENO2 MBP
12 psychotic disorder 29.9 BDNF COMT DRD2 S100B
13 hydrocephalus 29.9 APOE ENO2 GFAP IGF1 MAPT MBP
14 akinetic mutism 29.8 ENO2 MAPT
15 mood disorder 29.7 BDNF COMT DRD2 IL6
16 bacterial meningitis 29.7 IL10 IL6 S100B
17 heart disease 29.7 APOE IGF1 IL10 IL6 S100B
18 neurilemmoma 29.6 ENO2 GFAP S100B
19 human immunodeficiency virus infectious disease 29.6 IL10 IL6 S100B
20 personality disorder 29.6 BDNF COMT DRD2
21 substance abuse 29.6 BDNF COMT DRD2
22 neuromyelitis optica 29.5 GFAP IL6 MBP
23 neuroaxonal dystrophy 29.5 ENO2 IGF1 MBP
24 nutritional deficiency disease 29.5 EPO IGF1 IL6
25 supranuclear palsy, progressive, 1 29.4 APOE DRD2 MAPT
26 appendicitis 29.4 ENO2 IL10 IL6
27 eating disorder 29.3 BDNF COMT DRD2
28 multiple sclerosis 29.3 APOE BDNF GFAP IL10 IL6 MBP
29 bipolar disorder 29.3 BDNF COMT DRD2 IGF1 MAPT
30 amyotrophic lateral sclerosis 1 29.2 BDNF CASP3 GFAP IGF1 MAPT
31 major depressive disorder 29.1 APOE BDNF COMT DRD2 IL6
32 brain cancer 29.1 CASP3 ENO2 GFAP MBP
33 disease of mental health 29.0 APOE BDNF COMT DRD2 MAPT
34 central nervous system disease 28.8 APOE BDNF CASP3 GFAP IL6 MAPT
35 myocardial infarction 28.7 APOE CASP3 IL10 IL6 S100B
36 parkinson disease, late-onset 28.6 APOE BDNF CASP3 COMT DRD2 MAPT
37 moderate and severe traumatic brain injury 12.5
38 pseudobulbar affect 11.3
39 agnosia 11.3
40 locked-in syndrome 11.3
41 ocular motor apraxia 11.3
42 dementia pugilistica 11.2
43 cerebral hypoxia 11.2
44 epilepsy 11.2
45 dysphagia 11.2
46 shaken baby syndrome 11.2
47 post-traumatic epilepsy 11.2
48 cerebral atrophy 11.2
49 apraxia 11.1
50 swallowing disorders 11.1

Graphical network of the top 20 diseases related to Brain Injury:



Diseases related to Brain Injury
Sources

Symptoms & Phenotypes for Brain Injury

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GenomeRNAi Phenotypes related to Brain Injury according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 IL10
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Brain Injury:

46 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.45 APOE ASIC1 BDNF CASP3 COMT DRD2
2 homeostasis/metabolism MP:0005376 10.39 APOE BDNF CASP3 COMT DRD2 EPO
3 cellular MP:0005384 10.37 APOE BDNF CASP3 DRD2 ENO2 EPO
4 cardiovascular system MP:0005385 10.35 APOE CASP3 COMT DRD2 EPO GFAP
5 growth/size/body region MP:0005378 10.35 APOE BDNF CASP3 DRD2 ENO2 GFAP
6 nervous system MP:0003631 10.31 APOE ASIC1 BDNF CASP3 COMT DRD2
7 mortality/aging MP:0010768 10.27 APOE BDNF CASP3 DRD2 EPO GFAP
8 hematopoietic system MP:0005397 10.26 APOE CASP3 COMT DRD2 EPO IGF1
9 immune system MP:0005387 10.24 APOE CASP3 COMT DRD2 EPO GFAP
10 integument MP:0010771 10.22 APOE BDNF CASP3 DRD2 EPO IGF1
11 digestive/alimentary MP:0005381 10.15 APOE BDNF CASP3 DRD2 GFAP IL10
12 muscle MP:0005369 10.09 APOE CASP3 DRD2 EPO GFAP IGF1
13 normal MP:0002873 10.07 BDNF DRD2 EPO GFAP IGF1 IL10
14 renal/urinary system MP:0005367 9.92 APOE CASP3 COMT DRD2 IGF1 IL6
15 reproductive system MP:0005389 9.91 APOE BDNF CASP3 COMT DRD2 IGF1
16 respiratory system MP:0005388 9.9 APOE BDNF CASP3 COMT DRD2 ENO2
17 taste/olfaction MP:0005394 9.43 APOE BDNF CASP3 DRD2 ENO2 MAPT
18 vision/eye MP:0005391 9.28 APOE BDNF CASP3 GFAP IL10 IL6
Sources

Drugs & Therapeutics for Brain Injury

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Drugs for Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 683)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2 7440-66-6
2
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 57-27-2 5288826
3
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 69-65-8 453 6251
4
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
5
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
6
Citalopram Approved Phase 4,Phase 2,Not Applicable,Early Phase 1 59729-33-8 2771
7
Methylphenidate Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 113-45-1 4158
8
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
9
Amantadine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 768-94-5 2130
10
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
11
Ticlopidine Approved Phase 4 55142-85-3 5472
12 tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13
Sufentanil Approved, Investigational Phase 4,Phase 2 56030-54-7 41693
14
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
15
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
16
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 28523-86-6 5206
17
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 113775-47-6 68602 5311068
18
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2078-54-8 4943
19
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
20
Cisatracurium Approved Phase 4 96946-41-7
21
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
22
Levodopa Approved Phase 4,Phase 1,Phase 2 59-92-7 6047
23
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
24
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 99-66-1 3121
25
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2 1197-18-8 5526
26
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
27
Memantine Approved, Investigational Phase 4,Phase 2,Not Applicable 19982-08-2 4054
28
Etomidate Approved Phase 4 33125-97-2 667484 36339
29
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 437-38-7 3345
30
Acetylcholine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 51-84-3 187
31
Norepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 51-41-2 439260
32
Enoxaparin Approved Phase 4,Phase 1 9005-49-6 772
33
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 64-17-5 702
34
Caffeine Approved Phase 4,Phase 3,Not Applicable 58-08-2 2519
35
Acetaminophen Approved Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
36
Donepezil Approved Phase 4,Phase 3,Phase 1,Phase 2 120014-06-4 3152
37
Lamotrigine Approved, Investigational Phase 4,Phase 1,Phase 2 84057-84-1 3878
38
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-23-7 5754
39
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
40
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
41
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-03-3
42
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Not Applicable 15687-27-1 3672
43
Exenatide Approved, Investigational Phase 4,Not Applicable 141758-74-9 15991534
44
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 1 525-66-6 4946
45
Rivastigmine Approved, Investigational Phase 4,Phase 3 123441-03-2 77991
46
Testosterone Approved, Investigational Phase 4,Phase 2,Not Applicable 58-22-0 6013
47
Testosterone enanthate Approved Phase 4,Phase 2 315-37-7 9416
48
Methyltestosterone Approved Phase 4,Phase 2 58-18-4 6010
49
Testosterone undecanoate Approved, Investigational Phase 4,Phase 2 5949-44-0
50
Dalteparin Approved Phase 4,Phase 3,Phase 2 9005-49-6

Interventional clinical trials:

(show top 50) (show all 2643)
# Name Status NCT ID Phase Drugs
1 Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
2 Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury Unknown status NCT02161055 Phase 4 Insulin
3 The CAPTAIN Trial: Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery Unknown status NCT01606111 Phase 4 Cerebrolysin;0.9% NaCl, saline
4 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
5 Normothermia in Patients With Acute Cerebral Damage Unknown status NCT00491192 Phase 4 Diclofenac
6 Antidepressant Maintenance in Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
7 Methylphenidate for Attention Problems After Pediatric TBI Unknown status NCT01933217 Phase 4 Methylphenidate;Placebo
8 Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State Unknown status NCT00163878 Phase 4
9 Amantadine for Treatment of Symptoms of the Post-Traumatic Confusional State Unknown status NCT00693121 Phase 4 Amantadine hydrochloride;Placebo capsule
10 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
11 The Effect of Dexmedetomidine to Cognition of Geriatrics in Prolonged Surgery Unknown status NCT02123355 Phase 4 Induction of anesthesia;Sevoflurane, remifentanil ,vecuronium;Dexmedetomidine;Placebo
12 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
13 Efficiency of a Small-peptide Enteral Feeding Formula Compared to a Whole-protein Formula Unknown status NCT01833624 Phase 4
14 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
15 Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
16 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
17 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
18 TXA in the EMS on the Helicopter and the Ambulance Unknown status NCT02354885 Phase 4 Tranexamic Acid
19 Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD) Unknown status NCT01517711 Phase 4 Tramadol;Placebo
20 Creative Therapy to Affect Stroke Outcomes Unknown status NCT01455155 Phase 4
21 "Equistasi" and Gait in Hemiparesis Unknown status NCT02714478 Phase 4
22 Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:A Randomized Controlled Trial Unknown status NCT00196703 Phase 4 memantine
23 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
24 A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients Unknown status NCT02147678 Phase 4 Etomidate;Propofol;Remifentanil;Anesthesia induction
25 Sevoflurane Decreases the Risk of Postoperative Delirium After Cerebral Hypoxemia During Surgery Unknown status NCT02133638 Phase 4 Sevoflurane;Propofol
26 The Effect on the Older's Cognition of Dual-loop Target Controlled Infusion Guided by Narcotrend Index Unknown status NCT03010098 Phase 4
27 Consequence of Dexmedetomidine on Emergence Deliruim After Sevoflurane Anesthesia in Children With Cerebral Palsy Unknown status NCT02244515 Phase 4 dexmedetomidine
28 The Efficacy and Safety of MEDITOXIN® in Children With Cerebral Palsy Unknown status NCT01256021 Phase 4 Botulinum Toxin Type A
29 Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy Unknown status NCT02462018 Phase 4
30 Intravenous Exenatide in Patients With Acute Brain Injury Completed NCT02058940 Phase 4 Exenatide
31 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
32 An Extension Study Evaluating the Efficacy and Safety of Rivastigmine in Patients With Traumatic Brain Injury (TBI) With Persistent Cognitive Deficits Completed NCT00219245 Phase 4 Rivastigmine
33 Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery Completed NCT00035139 Phase 4 methylphenidate
34 Beta Blockade in in Traumatic Brain Injury Completed NCT02957331 Phase 4 Propranolol
35 Pharmacological Intervention in Depression After Traumatic Brain Injury Completed NCT00205491 Phase 4 Venlafaxine
36 The Relationship Between Traumatic Brain Injury and Dopamine (a Chemical in the Brain) Completed NCT02015949 Phase 4 Methylphenidate;Placebo
37 The Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury Completed NCT01339806 Phase 4
38 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
39 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed NCT00957671 Phase 4 Recombinant human growth hormone
40 Depression and Traumatic Brain Injury Completed NCT00254007 Phase 4 citalopram (celexa)
41 The Use of Low Molecular Weight Heparin in Traumatic Brain Injury Completed NCT00170378 Phase 4 Enoxaparin
42 Optimized Therapy in Severe Traumatic Brain Injured Patients Completed NCT02130674 Phase 4 Dipeptiven
43 Effect of Erythropoietin on Preterm Brain Injury Completed NCT02036073 Phase 4 recombinant human erythropoietin
44 Bispectral Index Value Changes During Induction and Surgical Decompression in Head Injury Patients Completed NCT03480880 Phase 4
45 Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention Completed NCT00618436 Phase 4 Levetiracetam;Phenytoin
46 Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI Completed NCT01750268 Phase 4 Topiramate;Placebo
47 Simvastatin for mTBI Completed NCT01952288 Phase 4 simvastatin;Placebo Oral Tablet
48 Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA) Completed NCT01799941 Phase 4 Nuedexta (DM 20 mg/Q 10 mg)
49 Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity Completed NCT00178646 Phase 4 Botox
50 Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies Completed NCT01695070 Phase 4 Melatonin

Search NIH Clinical Center for Brain Injury

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Injury:
Hematopoietic stem cells for treatment of ischemic brain injury
Embryonic/Adult Cultured Cells Related to Brain Injury:
Bone marrow-derived hematopoietic stem cells (family)
Sources

Genetic Tests for Brain Injury

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Anatomical Context for Brain Injury

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MalaCards organs/tissues related to Brain Injury:

41
Brain, Testes, Heart, Eye, Bone, Spinal Cord, Pituitary
Sources

Publications for Brain Injury

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Articles related to Brain Injury:

(show top 50) (show all 3838)
# Title Authors Year
1
ICU Structure and Outcomes Following Traumatic Brain Injury. ( 30557260 )
2019
2
The pig as a preclinical traumatic brain injury model: current models, functional outcome measures, and translational detection strategies. ( 30539807 )
2019
3
Intensive care admission criteria for traumatic brain injury patients across Europe. ( 30447560 )
2019
4
Rehabilitation Assessment and Management of Neurosensory Deficits After Traumatic Brain Injury in the Polytrauma Veteran. ( 30470419 )
2019
5
Vision Rehabilitation After Traumatic Brain Injury. ( 30470420 )
2019
6
Rehabilitation of Cognitive Dysfunction Following Traumatic Brain Injury. ( 30470421 )
2019
7
Outcomes of children with severe traumatic brain injury. ( 30473438 )
2019
8
The Pediatric Guideline Adherence and Outcomes (PEGASUS) programme in severe traumatic brain injury: a single-centre hybrid implementation and effectiveness study. ( 30473440 )
2019
9
Prognostic significance of serum translocator protein in patients with traumatic brain injury. ( 30385279 )
2019
10
Evaluation of serum pannexin-1 as a prognostic biomarker for traumatic brain injury. ( 30414433 )
2019
11
Inhibitory role of lentivirus-mediated aquaporin-4 gene silencing in the formation of glial scar in a rat model of traumatic brain injury. ( 30246455 )
2019
12
Frontal brain injury chronically impairs timing behavior in rats. ( 30213663 )
2019
13
High-mobility group box-1 translocation and release after hypoxic ischemic brain injury in neonatal rats. ( 30217406 )
2019
14
Predictive value of early MRI findings on neurocognitive and psychiatric outcomes in patients with severe traumatic brain injury. ( 30218878 )
2019
15
Neonatal brain injury and aberrant connectivity. ( 30059733 )
2019
16
Comparison of two prehospital predictive models for mortality and impaired consciousness after severe traumatic brain injury. ( 30117150 )
2019
17
A review of research efforts to address the 2008 ACEP guideline for mild traumatic brain injury. ( 29776825 )
2019
18
Association of Histologic Chorioamnionitis With Perinatal Brain Injury and Early Childhood Neurodevelopmental Outcomes Among Preterm Neonates. ( 29610829 )
2018
19
Effects of pregabalin on brain edema, neurologic and histologic outcomes in experimental traumatic brain injury. ( 29730418 )
2018
20
Perioperative neonatal brain injury is associated with worse school-age neurodevelopment in children with critical congenital heart disease. ( 29572821 )
2018
21
Brain injury and neural stem cells. ( 29451199 )
2018
22
Impaired autophagic flux is associated with the severity of trauma and the role of A<sub>2A</sub>R in brain cells after traumatic brain injury. ( 29449536 )
2018
23
Alpha desynchronization/synchronization during working memory testing is compromised in acute mild traumatic brain injury (mTBI). ( 29444081 )
2018
24
Intravenous saline administration in patients with severe acquired brain injury and orthostatic intolerance for tilt-table mobilization. ( 29190150 )
2018
25
OXIDIZED PHOSPHOLIPID SIGNALING IN TRAUMATIC BRAIN INJURY. ( 29964171 )
2018
26
Robotically-driven orthoses exert proximal-to-distal differential recovery on the lower limbs in children with hemiplegia, early after acquired brain injury. ( 29650492 )
2018
27
Phenol neurolysis for management of shoulder spasticity in early recovery from traumatic brain injury - a case report. ( 29933094 )
2018
28
Inhibition of HMGB1 mediates neuroprotection of traumatic brain injury by modulating the microglia/macrophage polarization. ( 29448108 )
2018
29
Safety, Tolerability, and Effectiveness of Dextromethorphan/Quinidine for Pseudobulbar Affect Among Study Participants With Traumatic Brain Injury: Results From the PRISM-II Open Label Study. ( 29477412 )
2018
30
Epileptiform activity in traumatic brain injury predicts post-traumatic epilepsy. ( 29537656 )
2018
31
Intracranial pressure thresholds in severe traumatic brain injury: Con : The injured brain is not aware of ICP thresholds! ( 29978388 )
2018
32
Mild traumatic brain injury: evaluation of olfactory dysfunction and clinical-neurological characteristics. ( 29446651 )
2018
33
Corrigendum: Image of the month: Dysphagia due to injury of the corticobulbar tract following traumatic brain injury. ( 29436459 )
2018
34
Long-term and delayed functional recovery in patients with severe cerebrovascular and traumatic brain injury requiring tracheostomy. ( 29979120 )
2018
35
Comparing disability between traumatic brain injury and spinal cord injury using the 12-item WHODAS 2.0 and the WHO minimal generic data set covering functioning and health. ( 29962230 )
2018
36
Traumatic Brain Injury and Firearm Use and Risk of Progressive Supranuclear Palsy Among Veterans. ( 29973911 )
2018
37
Clinical predictive score of intracranial hemorrhage in mild traumatic brain injury. ( 29440905 )
2018
38
Towards a Clinical Neuroethics for Brain Injury Practice: An Introduction to a New Special Feature for Ethics in JHTR. ( 29975255 )
2018
39
The incidence of anosmia after traumatic brain injury: the SHEFBIT cohort. ( 29874472 )
2018
40
Susceptibility-weighted and diffusion kurtosis imaging to evaluate encephalomalacia with epilepsy after traumatic brain injury. ( 29761118 )
2018
41
Evidence- and Consensus-Based Guidelines for the Management of Communication and Swallowing Disorders Following Pediatric Traumatic Brain Injury. ( 29385009 )
2018
42
The development of a new computer-adaptive test to evaluate strain in caregivers of individuals with traumatic brain injury: TBI-CareQOL Caregiver Strain. ( 29966647 )
2018
43
Risk of Traumatic Brain Injury Among Children, Adolescents, and Young Adults With Attention-Deficit Hyperactivity Disorder in Taiwan. ( 29970331 )
2018
44
Intracranial pressure thresholds in severe traumatic brain injury: Pro. ( 29978389 )
2018
45
Roles of elevated 20a89HETE in the breakdown of blood brain barrier and the severity of brain edema in experimental traumatic brain injury. ( 29568904 )
2018
46
Understanding health-related quality of life in caregivers of civilians and service members/veterans with traumatic brain injury: Reliability and validity data for the TBI-CareQOL measurement system. ( 29966648 )
2018
47
Theaflavin alleviates inflammatory response and brain injury induced by cerebral hemorrhage via inhibiting the nuclear transcription factor kappa I^-related pathway in rats. ( 29928110 )
2018
48
Obesity and Overweight Problems Among Individuals 1 to 25 Years Following Acute Rehabilitation for Traumatic Brain Injury: A NIDILRR Traumatic Brain Injury Model Systems Study. ( 29975254 )
2018
49
Alpha-Linolenic Acid Treatment Reduces the Contusion and Prevents the Development of Anxiety-Like Behavior Induced by a Mild Traumatic Brain Injury in Rats. ( 28844093 )
2018
50
Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia. ( 29551690 )
2018
Sources

Variations for Brain Injury

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Expression for Brain Injury

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Search GEO for disease gene expression data for Brain Injury.
Sources

Pathways for Brain Injury

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Pathways related to Brain Injury according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.95 BDNF CASP3 IL10 IL6
2
Neuroscience 4
11.76 APOE COMT ENO2 GFAP MAPT MBP
3
Amoebiasis 37
11.71 CASP3 IL10 IL6
4
Spinal Cord Injury 1
11.63 BDNF CASP3 GFAP IL6 MBP
5
Pertussis 37
11.57 CASP3 IL10 IL6
6
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.57 BDNF GFAP IGF1 S100B
7
LPA receptor mediated events 1
11.48 CASP3 IL6 MAPT
8
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.47 BDNF IGF1 IL10 IL6
9
Hepatitis C and Hepatocellular Carcinoma 1
11.36 CASP3 IL6 UCHL1
10
HIF-1 signaling pathway 37
11.35 ENO1 ENO2 EPO IGF1 IL6
11
Differentiation Pathway 1
11.31 EPO IGF1 IL6
12
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.23 APOE IGF1 IL6
13
Microglia Activation During Neuroinflammation: Steady-State Microglia 65
11.21 BDNF DRD2 IGF1 IL10
14
G-protein signaling_Rap2B regulation pathway 22
10.83 BDNF GFAP IGF1 IL10 IL6
15
ERK Pathway in Huntingtons Disease 1
10.68 BDNF CASP3
Sources

GO Terms for Brain Injury

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Cellular components related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 APOE BDNF ENO1 ENO2 EPO IGF1
2 dendrite GO:0030425 9.8 APOE BDNF COMT DRD2 MAPT
3 axon GO:0030424 9.77 BDNF COMT DRD2 MAPT UCHL1
4 myelin sheath GO:0043209 9.62 ENO2 GFAP MBP UCHL1
5 glial cell projection GO:0097386 9.43 GFAP MAPT
6 phosphopyruvate hydratase complex GO:0000015 9.26 ENO1 ENO2
7 cell body GO:0044297 9.26 COMT EPO GFAP MAPT
8 neuronal cell body GO:0043025 9.17 APOE CASP3 ENO2 MAPT MBP S100B
9 extracellular region GO:0005576 10.11 APOE BDNF EPO IGF1 IL10 IL6

Biological processes related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.67 CASP3 COMT EPO IL10
2 axonogenesis GO:0007409 9.65 DRD2 S100B UCHL1
3 regulation of signaling receptor activity GO:0010469 9.63 BDNF EPO IGF1 IL10 IL6 MAPT
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 EPO IGF1 IL6
5 long-term synaptic potentiation GO:0060291 9.5 GFAP S100B SLC24A2
6 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.46 IL10 MBP
7 axonal transport of mitochondrion GO:0019896 9.43 MAPT UCHL1
8 response to inactivity GO:0014854 9.26 DRD2 IL10
9 response to glucocorticoid GO:0051384 9.26 CASP3 IL10 IL6 S100B
10 memory GO:0007613 9.02 ASIC1 BDNF MAPT S100B SLC24A2

Molecular functions related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 BDNF IGF1 IL10 IL6
2 lipoprotein particle binding GO:0071813 9.16 APOE MAPT
3 phosphopyruvate hydratase activity GO:0004634 8.62 ENO1 ENO2
4 protein binding GO:0005515 10.19 APOE ASIC1 CASP3 COMT DRD2 ENO1
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Sources for Brain Injury

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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