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MCID: BRN071
MIFTS: 55

Brain Injury

Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Brain Injury

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MalaCards integrated aliases for Brain Injury:

Name: Brain Injury 39 55

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


Sources

Summaries for Brain Injury

About this section
NINDS : 55 Traumatic brain injury (TBI), a form of acquired brain injury, occurs when a sudden trauma causes damage to the brain. TBI can result when the head suddenly and violently hits an object, or when an object pierces the skull and enters brain tissue.  Symptoms of a TBI can be mild, moderate, or severe, depending on the extent of the damage to the brain. A person with a mild TBI may remain conscious or may experience a loss of consciousness for a few seconds or minutes. Other symptoms of mild TBI include headache, confusion, lightheadedness, dizziness, blurred vision or tired eyes, ringing in the ears, bad taste in the mouth, fatigue or lethargy, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration, attention, or thinking.  A person with a moderate or severe TBI may show these same symptoms, but may also have a headache that gets worse or does not go away, repeated vomiting or nausea, convulsions or seizures, an inability to awaken from sleep, dilation of one or both pupils of the eyes, slurred speech, weakness or numbness in the extremities, loss of coordination, and increased confusion, restlessness, or agitation.

MalaCards based summary : Brain Injury is related to neonatal hypoxic and ischemic brain injury and head injury. An important gene associated with Brain Injury is ASIC1 (Acid Sensing Ion Channel Subunit 1), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Neuroscience. The drugs Zinc and Morphine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

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Related Diseases for Brain Injury

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Diseases related to Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 500)
# Related Disease Score Top Affiliating Genes
1 neonatal hypoxic and ischemic brain injury 34.1 BDNF ENO2 MBP
2 head injury 32.9 APOE ENO2 S100B
3 persistent vegetative state 32.5 APOE ENO2
4 periventricular leukomalacia 32.4 EPO IL6 MBP
5 aphasia 31.9 APOE BDNF MAPT
6 alzheimer disease 31.1 APOE BDNF CASP3 GFAP MAPT S100B
7 traumatic brain injury 31.0 APOE BDNF CASP3 COMT DRD2 ENO2
8 post-traumatic stress disorder 30.7 APOE BDNF COMT DRD2
9 spinal cord injury 30.6 BDNF CASP3 GFAP IL6
10 stroke, ischemic 30.5 APOE CASP3 ENO2 MBP
11 status epilepticus 30.4 BDNF CASP3 ENO2 GFAP
12 substance abuse 30.3 BDNF COMT DRD2
13 bacterial meningitis 30.1 IL10 IL6 S100B
14 mood disorder 30.0 BDNF COMT DRD2 IL6
15 psychotic disorder 29.9 BDNF COMT DRD2 S100B
16 neurilemmoma 29.8 ENO2 GFAP S100B
17 akinetic mutism 29.8 ENO2 MAPT
18 personality disorder 29.8 BDNF COMT DRD2
19 heart disease 29.8 APOE IGF1 IL10 IL6 S100B
20 human immunodeficiency virus infectious disease 29.7 IL10 IL6 S100B
21 hydrocephalus 29.7 APOE ENO2 GFAP IGF1 MAPT MBP
22 neuromyelitis optica 29.7 GFAP IL6 MBP
23 neuroaxonal dystrophy 29.6 ENO2 IGF1 MBP
24 eating disorder 29.6 BDNF COMT DRD2
25 appendicitis 29.5 ENO2 IL10 IL6
26 disease of mental health 29.5 APOE BDNF COMT DRD2 IL6 MAPT
27 sleep apnea 29.5 APOE IGF1 IL6 S100B
28 generalized anxiety disorder 29.4 BDNF COMT DRD2
29 vascular dementia 29.4 APOE MAPT MBP
30 major depressive disorder 29.4 APOE BDNF COMT DRD2 IL6
31 multiple sclerosis 29.3 APOE BDNF GFAP IL10 IL6 MBP
32 amyotrophic lateral sclerosis 1 29.2 BDNF CASP3 GFAP IGF1 MAPT
33 huntington disease 29.0 BDNF CASP3 DRD2 IGF1
34 myocardial infarction 28.9 APOE CASP3 IL10 IL6 S100B
35 parkinson disease, late-onset 28.7 APOE BDNF CASP3 COMT DRD2 MAPT
36 central nervous system disease 28.5 APOE BDNF CASP3 GFAP IL6 MAPT
37 moderate and severe traumatic brain injury 12.5
38 ocular motor apraxia 11.3
39 pseudobulbar affect 11.3
40 agnosia 11.3
41 locked-in syndrome 11.3
42 dysphagia 11.2
43 dementia pugilistica 11.2
44 epilepsy 11.2
45 cerebral hypoxia 11.2
46 shaken baby syndrome 11.2
47 post-traumatic epilepsy 11.2
48 cerebral atrophy 11.2
49 apraxia 11.2
50 swallowing disorders 11.2

Graphical network of the top 20 diseases related to Brain Injury:



Diseases related to Brain Injury
Sources

Symptoms & Phenotypes for Brain Injury

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GenomeRNAi Phenotypes related to Brain Injury according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 IL10
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Brain Injury:

47 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.45 APOE ASIC1 BDNF CASP3 COMT DRD2
2 homeostasis/metabolism MP:0005376 10.39 APOE BDNF CASP3 COMT DRD2 EPO
3 cellular MP:0005384 10.37 APOE BDNF CASP3 DRD2 ENO2 EPO
4 cardiovascular system MP:0005385 10.35 APOE CASP3 COMT DRD2 EPO GFAP
5 growth/size/body region MP:0005378 10.35 APOE BDNF CASP3 DRD2 ENO2 GFAP
6 nervous system MP:0003631 10.31 APOE ASIC1 BDNF CASP3 COMT DRD2
7 mortality/aging MP:0010768 10.27 APOE BDNF CASP3 DRD2 EPO GFAP
8 hematopoietic system MP:0005397 10.26 APOE CASP3 COMT DRD2 EPO IGF1
9 immune system MP:0005387 10.24 APOE CASP3 COMT DRD2 EPO GFAP
10 integument MP:0010771 10.22 APOE BDNF CASP3 DRD2 EPO IGF1
11 digestive/alimentary MP:0005381 10.15 APOE BDNF CASP3 DRD2 GFAP IL10
12 muscle MP:0005369 10.09 APOE CASP3 DRD2 EPO GFAP IGF1
13 normal MP:0002873 10.07 BDNF DRD2 EPO GFAP IGF1 IL10
14 renal/urinary system MP:0005367 9.92 APOE CASP3 COMT DRD2 IGF1 IL6
15 reproductive system MP:0005389 9.91 APOE BDNF CASP3 COMT DRD2 IGF1
16 respiratory system MP:0005388 9.9 APOE BDNF CASP3 COMT DRD2 ENO2
17 taste/olfaction MP:0005394 9.43 APOE BDNF CASP3 DRD2 ENO2 MAPT
18 vision/eye MP:0005391 9.28 APOE BDNF CASP3 GFAP IL10 IL6
Sources

Drugs & Therapeutics for Brain Injury

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Drugs for Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 706)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 7440-66-6 32051
2
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 57-27-2 5288826
3
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 69-65-8 6251 453
4
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1 59467-70-8 4192
5
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
6
Citalopram Approved Phase 4,Phase 2,Not Applicable,Early Phase 1 59729-33-8 2771
7
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 62-31-7, 51-61-6 681
8
Methylphenidate Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 113-45-1 4158
9
Amantadine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 768-94-5 2130
10
Atorvastatin Approved Phase 4,Phase 3,Phase 1,Phase 2 134523-00-5 60823
11
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
12
tannic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1401-55-4
13
Sufentanil Approved, Investigational Phase 4,Phase 2 56030-54-7 41693
14
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1994-09-7, 94-09-7 2337
15
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
16
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 28523-86-6 5206
17
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 113775-47-6 5311068 68602
18
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2078-54-8 4943
19
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
20
Cisatracurium Approved Phase 4 96946-41-7
21
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
22
Levodopa Approved Phase 4,Phase 1,Phase 2 59-92-7 6047
23
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
24
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 1,Not Applicable 99-66-1 3121
25
Tranexamic Acid Approved Phase 4,Phase 3,Phase 2 1197-18-8 5526
26
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
27
Memantine Approved, Investigational Phase 4,Phase 2,Not Applicable 19982-08-2 4054
28
Etomidate Approved Phase 4 33125-97-2 667484 36339
29
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 437-38-7 3345
30
Norepinephrine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 51-41-2 439260
31
Testosterone Approved, Experimental, Investigational Phase 4,Phase 2,Not Applicable 58-22-0, 481-30-1 10204 6013
32
Enoxaparin Approved Phase 4,Phase 1 9005-49-6 772
33
Ethanol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 64-17-5 702
34
Acetylcholine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 51-84-3 187
35
Sodium Citrate Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 68-04-2
36
Caffeine Approved Phase 4,Phase 3,Phase 1,Not Applicable 58-08-2 2519
37
Acetaminophen Approved Phase 4,Phase 2,Phase 1,Not Applicable,Early Phase 1 103-90-2 1983
38
Donepezil Approved Phase 4,Phase 3,Phase 1,Phase 2 120014-06-4 3152
39
Lamotrigine Approved, Investigational Phase 4,Phase 1,Phase 2 84057-84-1 3878
40
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-23-7 5754
41
Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 329-65-7 838
42
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-43-4 5816
43
Hydrocortisone acetate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 50-03-3
44
Ibuprofen Approved Phase 4,Phase 3,Phase 2,Not Applicable 15687-27-1 3672
45
Exenatide Approved, Investigational Phase 4,Not Applicable 141758-74-9 15991534
46
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 1 525-66-6 4946
47
Rivastigmine Approved, Investigational Phase 4,Phase 3 123441-03-2 77991
48
Testosterone enanthate Approved Phase 4,Phase 2 315-37-7 9416
49
Methyltestosterone Approved Phase 4,Phase 2 58-18-4 6010
50
Testosterone undecanoate Approved, Investigational Phase 4,Phase 2 5949-44-0

Interventional clinical trials:

(show top 50) (show all 2772)
# Name Status NCT ID Phase Drugs
1 Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
2 Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury Unknown status NCT02161055 Phase 4 Insulin
3 The CAPTAIN Trial: Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery Unknown status NCT01606111 Phase 4 Cerebrolysin;0.9% NaCl, saline
4 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
5 Normothermia in Patients With Acute Cerebral Damage Unknown status NCT00491192 Phase 4 Diclofenac
6 Antidepressant Maintenance in Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
7 Methylphenidate for Attention Problems After Pediatric TBI Unknown status NCT01933217 Phase 4 Methylphenidate;Placebo
8 Is Sensory Stimulation Effective in Reducing Time Spent in a Coma or Vegetative State Unknown status NCT00163878 Phase 4
9 Amantadine for Treatment of Symptoms of the Post-Traumatic Confusional State Unknown status NCT00693121 Phase 4 Amantadine hydrochloride;Placebo capsule
10 Clopidogrel and Atorvastatin Treatment During Carotid Artery Stenting Unknown status NCT01572623 Phase 4 Clopidogrel;Atorvastatin
11 The Effect of Dexmedetomidine to Cognition of Geriatrics in Prolonged Surgery Unknown status NCT02123355 Phase 4 Induction of anesthesia;Sevoflurane, remifentanil ,vecuronium;Dexmedetomidine;Placebo
12 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents Unknown status NCT02404779 Phase 4 cisatracurium besilate
13 Efficiency of a Small-peptide Enteral Feeding Formula Compared to a Whole-protein Formula Unknown status NCT01833624 Phase 4
14 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
15 Intensive Insulin Therapy for Strict Glycemic Control in Neurosurgical Patients: Safety and Efficacy Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
16 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
17 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
18 TXA in the EMS on the Helicopter and the Ambulance Unknown status NCT02354885 Phase 4 Tranexamic Acid
19 Tramadol Extended-Release (ER) for Posttraumatic Stress Disorder (PTSD) Unknown status NCT01517711 Phase 4 Tramadol;Placebo
20 Creative Therapy to Affect Stroke Outcomes Unknown status NCT01455155 Phase 4
21 "Equistasi" and Gait in Hemiparesis Unknown status NCT02714478 Phase 4
22 Memantine and Constraint-Induced Language Therapy in Chronic Poststroke Aphasia:A Randomized Controlled Trial Unknown status NCT00196703 Phase 4 memantine
23 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
24 A Comparison Between Propofol and Etomidate in Hysteroscopy on Effect of Postoperative Sedation and Cognitive Function in Elderly Patients Unknown status NCT02147678 Phase 4 Etomidate;Propofol;Remifentanil;Anesthesia induction
25 Sevoflurane Decreases the Risk of Postoperative Delirium After Cerebral Hypoxemia During Surgery Unknown status NCT02133638 Phase 4 Sevoflurane;Propofol
26 The Effect on the Older's Cognition of Dual-loop Target Controlled Infusion Guided by Narcotrend Index Unknown status NCT03010098 Phase 4
27 Consequence of Dexmedetomidine on Emergence Deliruim After Sevoflurane Anesthesia in Children With Cerebral Palsy Unknown status NCT02244515 Phase 4 dexmedetomidine
28 Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy Unknown status NCT02462018 Phase 4
29 Intravenous Exenatide in Patients With Acute Brain Injury Completed NCT02058940 Phase 4 Exenatide
30 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
31 An Extension Study Evaluating the Efficacy and Safety of Rivastigmine in Patients With Traumatic Brain Injury (TBI) With Persistent Cognitive Deficits Completed NCT00219245 Phase 4 Rivastigmine
32 Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery Completed NCT00035139 Phase 4 methylphenidate
33 Beta Blockade in in Traumatic Brain Injury Completed NCT02957331 Phase 4 Propranolol
34 Pharmacological Intervention in Depression After Traumatic Brain Injury Completed NCT00205491 Phase 4 Venlafaxine
35 The Relationship Between Traumatic Brain Injury and Dopamine (a Chemical in the Brain) Completed NCT02015949 Phase 4 Methylphenidate;Placebo
36 The Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury Completed NCT01339806 Phase 4
37 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
38 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed NCT00957671 Phase 4 Recombinant human growth hormone
39 Depression and Traumatic Brain Injury Completed NCT00254007 Phase 4 citalopram (celexa)
40 The Use of Low Molecular Weight Heparin in Traumatic Brain Injury Completed NCT00170378 Phase 4 Enoxaparin
41 Optimized Therapy in Severe Traumatic Brain Injured Patients Completed NCT02130674 Phase 4 Dipeptiven
42 Effect of Erythropoietin on Preterm Brain Injury Completed NCT02036073 Phase 4 recombinant human erythropoietin
43 Bispectral Index Value Changes During Induction and Surgical Decompression in Head Injury Patients Completed NCT03480880 Phase 4
44 Assess Safety and Efficacy of Levetiracetam(LEV;Keppra)for Seizure Prevention Completed NCT00618436 Phase 4 Levetiracetam;Phenytoin
45 Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI Completed NCT01750268 Phase 4 Topiramate;Placebo
46 Simvastatin for mTBI Completed NCT01952288 Phase 4 simvastatin;Placebo Oral Tablet
47 Safety, Tolerability and Effectiveness of Nuedexta in the Treatment of Pseudobulbar Affect (PBA) Completed NCT01799941 Phase 4 Nuedexta (DM 20 mg/Q 10 mg)
48 Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity Completed NCT00178646 Phase 4 Botox
49 Melatonin to Prevent Brain Injury in Unborn Growth Restricted Babies Completed NCT01695070 Phase 4 Melatonin
50 BOTOX® Versus Zanaflex® for the Treatment of Post-Stroke or Traumatic Brain Injury Upper Limb Spasticity Completed NCT00430196 Phase 4 BOTOX®;Zanaflex®

Search NIH Clinical Center for Brain Injury

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Injury:
Hematopoietic stem cells for treatment of ischemic brain injury
Embryonic/Adult Cultured Cells Related to Brain Injury:
Bone marrow-derived hematopoietic stem cells (family)
Sources

Genetic Tests for Brain Injury

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Sources

Anatomical Context for Brain Injury

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MalaCards organs/tissues related to Brain Injury:

42
Brain, Testes, Bone, Heart, Eye, Pituitary, Spinal Cord
Sources

Publications for Brain Injury

About this section

Articles related to Brain Injury:

(show top 50) (show all 6834)
# Title Authors Year
1
Acid sphingomyelinase deficiency protects mitochondria and improves function recovery after brain injury. ( 30662008 )
2019
2
Young plasma ameliorates aging-related acute brain injury after intracerebral hemorrhage. ( 31040201 )
2019
3
Normal aging hyperactivates innate immunity and reduces the medical efficacy of minocycline in brain injury. ( 30986429 )
2019
4
The effect of aging on brain injury and recovery after stroke. ( 31010535 )
2019
5
Interactive Effect of Traumatic Brain Injury and Psychiatric Symptoms on Cognition among Late Middle-Aged Men: Findings from the Vietnam Era Twin Study of Aging. ( 29978738 )
2019
6
Alcohol dependence treating agent, acamprosate, prevents traumatic brain injury-induced neuron death through vesicular zinc depletion. ( 30731068 )
2019
7
Memantine: From Alzheimer Disease to Traumatic Brain Injury. ( 30471450 )
2019
8
Psychometric Evaluation of Anxiety, Depression, and Sleep Quality after a Mild Traumatic Brain Injury: A Longitudinal Study. ( 31110595 )
2019
9
Quercetin mitigates anxiety-like behavior and normalizes hypothalamus-pituitary-adrenal axis function in a mouse model of mild traumatic brain injury. ( 30882424 )
2019
10
The blockade of corticotropin-releasing factor 1 receptor attenuates anxiety-related symptoms and hypothalamus-pituitary-adrenal axis reactivity in mice with mild traumatic brain injury. ( 30883392 )
2019
11
Severe Perinatal Hypoxic-Ischemic Brain Injury Induces Long-Term Sensorimotor Deficits, Anxiety-Like Behaviors and Cognitive Impairment in a Sex-, Age- and Task-Selective Manner in C57BL/6 Mice but Can Be Modulated by Neonatal Handling. ( 30814939 )
2019
12
Long-Term Effects of Traumatic Brain Injury on Anxiety-Like Behaviors in Mice: Behavioral and Neural Correlates. ( 30728770 )
2019
13
A study of the influence of cognitive complaints, cognitive performance and symptoms of anxiety and depression on self-efficacy in patients with acquired brain injury. ( 30168362 )
2019
14
A Large-Scale Comparison of Main Concept Production Between Persons With Aphasia and Persons Without Brain Injury. ( 31072179 )
2019
15
Risks of bipolar disorder, depressive disorder, and traumatic brain injury among siblings of patients with attention-deficit hyperactivity disorder. ( 30419534 )
2019
16
Polygenic Risk and Neural Substrates of Attention-Deficit/Hyperactivity Disorder Symptoms in Youths With a History of Mild Traumatic Brain Injury. ( 30119875 )
2019
17
Cerebral Edema and Neurological Recovery after Traumatic Brain Injury Are Worsened if Accompanied by a Concomitant Long Bone Fracture. ( 30084745 )
2019
18
Lack of Benefit on Brain Edema, Blood-Brain Barrier Permeability, or Cognitive Outcome in Global Inducible High Mobility Group Box 1 Knockout Mice Despite Tissue Sparing after Experimental Traumatic Brain Injury. ( 30045665 )
2019
19
Deficiency of plasminogen activator inhibitor type 2 limits brain edema formation after traumatic brain injury. ( 30755137 )
2019
20
Dynamic features of brain edema in rat models of traumatic brain injury. ( 30969247 )
2019
21
Strategies to Cope With Behavior Changes After Acquired Brain Injury. ( 31060788 )
2019
22
IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice. ( 31061403 )
2019
23
Human 3D cellular model of hypoxic brain injury of prematurity. ( 31061540 )
2019
24
Handling of missing outcome data in traumatic brain injury research - a systematic review. ( 31062649 )
2019
25
Comparing Composite Scores for the ANAM4 TBI-MIL for Research in Mild Traumatic Brain Injury. ( 31063188 )
2019
26
Prophylactic Hypothermia for Severe Traumatic Brain Injury. ( 31063565 )
2019
27
Prophylactic Hypothermia for Severe Traumatic Brain Injury-Reply. ( 31063568 )
2019
28
Therapeutical effects of chrysin in a rat model of traumatic brain injury: A behavioral, biochemical, and histological evidence. ( 31063733 )
2019
29
Correlation between cerebral co-oximetry (rSO2) and outcomes in traumatic brain injury cases: A prospective, observational study. ( 31065189 )
2019
30
Post-traumatic Anterior Cerebral Artery Rupture after a Severe Traumatic Brain Injury. ( 31065211 )
2019
31
Hypopituitarism After Traumatic Brain Injury. ( 31065469 )
2019
32
Cornel iridoid glycoside exerts a neuroprotective effect on neuroinflammation in rats with brain injury by inhibiting NF-κB and STAT3. ( 31065495 )
2019
33
Comparison of cranial ultrasound and MRI for detecting BRAIN injury in extremely preterm infants and correlation with neurological outcomes at 1 and 3 years. ( 31065842 )
2019
34
Immunomodulation with Human Umbilical Cord Blood Stem Cells Ameliorates Ischemic Brain Injury - A Brain Transcriptome Profiling Analysis. ( 31066288 )
2019
35
Relations of neuropeptide Y and heme oxygenase-1 expressions with fetal brain injury in rats with intrahepatic cholestasis of pregnancy. ( 31066785 )
2019
36
Association of Statewide Implementation of the Prehospital Traumatic Brain Injury Treatment Guidelines With Patient Survival Following Traumatic Brain Injury: The Excellence in Prehospital Injury Care (EPIC) Study. ( 31066879 )
2019
37
Patient-reported auditory handicap measures following mild traumatic brain injury. ( 31066921 )
2019
38
Indirect Traumatic Optic Neuropathy in Mild Chronic Traumatic Brain Injury. ( 31067321 )
2019
39
Altered Mental Status in Children After Traumatic Brain Injury. ( 31067334 )
2019
40
Peer support interventions for individuals with acquired brain injury, cerebral palsy, and spina bifida: a systematic review. ( 31068184 )
2019
41
Glutamate Transport and Preterm Brain Injury. ( 31068830 )
2019
42
Stroke Dysbiosis Index (SDI) in Gut Microbiome Are Associated With Brain Injury and Prognosis of Stroke. ( 31068891 )
2019
43
Airbag related penetrating brain injury. ( 31069920 )
2019
44
Impact of Perioperative Brain Injury and Development on Feeding Modality in Infants With Single Ventricle Heart Disease. ( 31070077 )
2019
45
Social rehabilitation for military veterans with traumatic brain injury, psychological trauma, and chronic neuropsychiatric symptoms: Intervention development and initial outcomes. ( 31070444 )
2019
46
In-hospital costs after severe traumatic brain injury: A systematic review and quality assessment. ( 31071199 )
2019
47
Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury. ( 31071926 )
2019
48
Cathodal Transcranial Direct-Current Stimulation Selectively Decreases Impulsivity after Traumatic Brain Injury in Rats. ( 31072218 )
2019
49
A serum protein biomarker panel improves outcome prediction in human traumatic brain injury. ( 31072225 )
2019
50
Gene expression profile of the hippocampus of rats subjected to traumatic brain injury. ( 31074048 )
2019
Sources

Variations for Brain Injury

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Sources

Expression for Brain Injury

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Search GEO for disease gene expression data for Brain Injury.
Sources

Pathways for Brain Injury

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Pathways related to Brain Injury according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.95 BDNF CASP3 IL10 IL6
2
Neuroscience 4
11.76 APOE COMT ENO2 GFAP MAPT MBP
3
Amoebiasis 38
11.71 CASP3 IL10 IL6
4
Spinal Cord Injury 1
11.63 BDNF CASP3 GFAP IL6 MBP
5
Pertussis 38
11.57 CASP3 IL10 IL6
6
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 66
11.57 BDNF GFAP IGF1 S100B
7
LPA receptor mediated events 1
11.48 CASP3 IL6 MAPT
8
Microglia Activation During Neuroinflammation: Microglia Polarization 66
11.47 BDNF IGF1 IL10 IL6
9
Hepatitis C and Hepatocellular Carcinoma 1
11.36 CASP3 IL6 UCHL1
10
HIF-1 signaling pathway 38
11.35 ENO1 ENO2 EPO IGF1 IL6
11
Differentiation Pathway 1
11.31 EPO IGF1 IL6
12
Transcription_Role of VDR in regulation of genes involved in osteoporosis 23
11.23 APOE IGF1 IL6
13
Microglia Activation During Neuroinflammation: Steady-State Microglia 66
11.21 BDNF DRD2 IGF1 IL10
14
G-protein signaling_Rap2B regulation pathway 23
10.83 BDNF GFAP IGF1 IL10 IL6
15
ERK Pathway in Huntingtons Disease 1
10.68 BDNF CASP3
Sources

GO Terms for Brain Injury

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Cellular components related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 APOE BDNF ENO1 ENO2 EPO IGF1
2 dendrite GO:0030425 9.8 APOE BDNF COMT DRD2 MAPT
3 axon GO:0030424 9.77 BDNF COMT DRD2 MAPT UCHL1
4 glial cell projection GO:0097386 9.43 GFAP MAPT
5 phosphopyruvate hydratase complex GO:0000015 9.26 ENO1 ENO2
6 cell body GO:0044297 9.26 COMT EPO GFAP MAPT
7 neuronal cell body GO:0043025 9.17 APOE CASP3 ENO2 MAPT MBP S100B
8 myelin sheath GO:0043209 9.02 MBP
9 extracellular region GO:0005576 10.11 APOE BDNF EPO IGF1 IL10 IL6

Biological processes related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.67 CASP3 COMT EPO IL10
2 axonogenesis GO:0007409 9.65 DRD2 S100B UCHL1
3 regulation of signaling receptor activity GO:0010469 9.63 BDNF EPO IGF1 IL10 IL6 MAPT
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.58 EPO IGF1 IL6
5 long-term synaptic potentiation GO:0060291 9.5 GFAP S100B SLC24A2
6 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.46 IL10 MBP
7 axonal transport of mitochondrion GO:0019896 9.43 MAPT UCHL1
8 response to inactivity GO:0014854 9.26 DRD2 IL10
9 response to glucocorticoid GO:0051384 9.26 CASP3 IL10 IL6 S100B
10 memory GO:0007613 9.02 ASIC1 BDNF MAPT S100B SLC24A2

Molecular functions related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.26 BDNF IGF1 IL10 IL6
2 lipoprotein particle binding GO:0071813 9.16 APOE MAPT
3 phosphopyruvate hydratase activity GO:0004634 8.62 ENO1 ENO2
4 protein binding GO:0005515 10.19 APOE ASIC1 CASP3 COMT DRD2 ENO1
Sources

Sources for Brain Injury

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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