MCID: BRN071
MIFTS: 51

Brain Injury

Categories: Neuronal diseases

Aliases & Classifications for Brain Injury

MalaCards integrated aliases for Brain Injury:

Name: Brain Injury 54 38

Classifications:



Summaries for Brain Injury

NINDS : 54 Traumatic brain injury (TBI), a form of acquired brain injury, occurs when a sudden trauma causes damage to the brain. TBI can result when the head suddenly and violently hits an object, or when an object pierces the skull and enters brain tissue.  Symptoms of a TBI can be mild, moderate, or severe, depending on the extent of the damage to the brain. A person with a mild TBI may remain conscious or may experience a loss of consciousness for a few seconds or minutes. Other symptoms of mild TBI include headache, confusion, lightheadedness, dizziness, blurred vision or tired eyes, ringing in the ears, bad taste in the mouth, fatigue or lethargy, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration, attention, or thinking.  A person with a moderate or severe TBI may show these same symptoms, but may also have a headache that gets worse or does not go away, repeated vomiting or nausea, convulsions or seizures, an inability to awaken from sleep, dilation of one or both pupils of the eyes, slurred speech, weakness or numbness in the extremities, loss of coordination, and increased confusion, restlessness, or agitation.

MalaCards based summary : Brain Injury is related to neonatal hypoxic and ischemic brain injury and head injury. An important gene associated with Brain Injury is ASIC1 (Acid Sensing Ion Channel Subunit 1), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and Neuroscience. The drugs Diclofenac and Cisatracurium have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Brain Injury

Diseases related to Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 946)
# Related Disease Score Top Affiliating Genes
1 neonatal hypoxic and ischemic brain injury 34.6 MBP ENO2 BDNF
2 head injury 33.7 S100B ENO2 APOE
3 persistent vegetative state 33.2 ENO2 APOE
4 periventricular leukomalacia 32.9 MBP IL6 EPO
5 aphasia 32.0 MAPT BDNF APOE
6 brain edema 31.8 IL6 GFAP AQP4
7 post-traumatic stress disorder 31.1 DRD2 COMT BDNF APOE
8 substance abuse 31.1 DRD2 COMT BDNF
9 status epilepticus 31.1 GFAP ENO2 CASP3 BDNF
10 sleep apnea 30.7 S100B IL6 IGF1 APOE
11 spinal cord injury 30.6 IL6 GFAP CASP3 BDNF AQP4
12 generalized anxiety disorder 30.6 DRD2 COMT BDNF
13 mood disorder 30.6 IL6 DRD2 COMT BDNF
14 personality disorder 30.6 DRD2 COMT BDNF
15 alzheimer disease 30.5 UCHL1 S100B MAPT GFAP CASP3 BDNF
16 ganglioglioma 30.4 S100B GFAP ENO2
17 bacterial meningitis 30.4 S100B IL6 IL10
18 alexia 30.3 MBP AQP4 APOE
19 stroke, ischemic 30.3 MBP ENO2 CASP3 AQP4 APOE
20 psychotic disorder 30.3 S100B DRD2 COMT BDNF
21 substance dependence 30.3 IL6 DRD2 BDNF
22 ependymoma 30.2 S100B GFAP ENO2
23 finger agnosia 30.2 MBP ENO2
24 neurilemmoma 30.2 S100B GFAP ENO2
25 major depressive disorder 30.2 IL6 DRD2 COMT BDNF APOE
26 oligodendroglioma 30.0 S100B MBP GFAP ENO2
27 akinetic mutism 29.9 MAPT ENO2
28 eating disorder 29.9 DRD2 COMT BDNF
29 vascular dementia 29.9 MBP MAPT APOE
30 neuroaxonal dystrophy 29.8 MBP IGF1 ENO2
31 huntington disease 29.8 IGF1 DRD2 CASP3 BDNF
32 nutritional deficiency disease 29.8 IL6 IGF1 EPO
33 acquired immunodeficiency syndrome 29.8 IL6 IL10 EPO
34 appendicitis 29.7 IL6 IL10 ENO2
35 neuromyelitis optica 29.7 MBP IL6 GFAP AQP4
36 hydrocephalus 29.7 MBP MAPT IGF1 GFAP ENO2 APOE
37 schizoaffective disorder 29.7 DRD2 COMT BDNF
38 secondary progressive multiple sclerosis 29.6 S100B MBP IL10 ENO2
39 ideomotor apraxia 29.6 MBP MAPT
40 heart disease 29.5 S100B IL6 IL10 IGF1 APOE
41 fibromyalgia 29.4 IL6 IGF1 COMT
42 viral encephalitis 29.4 MBP IL6 IL10
43 amyotrophic lateral sclerosis 1 29.4 MAPT IGF1 GFAP CASP3 BDNF
44 creutzfeldt-jakob disease 29.4 S100B MAPT ENO2 APOE
45 myeloma, multiple 29.3 IL6 IGF1 EPO CASP3
46 brain cancer 29.3 MBP GFAP ENO2 CASP3 AQP4
47 gilles de la tourette syndrome 29.3 DRD2 COMT BDNF
48 peripheral nervous system disease 29.3 MBP IL6 AQP4
49 demyelinating disease 29.2 MBP IL10 AQP4
50 schizophreniform disorder 29.1 DRD2 COMT

Graphical network of the top 20 diseases related to Brain Injury:



Diseases related to Brain Injury

Symptoms & Phenotypes for Brain Injury

GenomeRNAi Phenotypes related to Brain Injury according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 IL10
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Brain Injury:

46 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.5 APOE AQP4 ASIC1 BDNF CASP3 COMT
2 homeostasis/metabolism MP:0005376 10.43 APOE AQP4 BDNF CASP3 COMT DRD2
3 cardiovascular system MP:0005385 10.4 APOE AQP4 CASP3 COMT DRD2 EPO
4 cellular MP:0005384 10.4 APOE BDNF CASP3 DRD2 ENO2 EPO
5 growth/size/body region MP:0005378 10.4 APOE AQP4 BDNF CASP3 DRD2 ENO2
6 nervous system MP:0003631 10.36 APOE AQP4 ASIC1 BDNF CASP3 COMT
7 mortality/aging MP:0010768 10.32 APOE AQP4 BDNF CASP3 DRD2 EPO
8 hematopoietic system MP:0005397 10.31 APOE AQP4 CASP3 COMT DRD2 EPO
9 immune system MP:0005387 10.29 APOE AQP4 CASP3 COMT DRD2 EPO
10 integument MP:0010771 10.24 APOE BDNF CASP3 DRD2 EPO IGF1
11 digestive/alimentary MP:0005381 10.23 APOE AQP4 BDNF CASP3 DRD2 GFAP
12 endocrine/exocrine gland MP:0005379 10.22 APOE AQP4 BDNF CASP3 COMT DRD2
13 muscle MP:0005369 10.11 APOE CASP3 DRD2 EPO GFAP IGF1
14 normal MP:0002873 10.07 BDNF DRD2 EPO GFAP IGF1 IL10
15 hearing/vestibular/ear MP:0005377 10.02 APOE AQP4 BDNF CASP3 IGF1 MBP
16 renal/urinary system MP:0005367 9.97 APOE AQP4 CASP3 COMT DRD2 IGF1
17 no phenotypic analysis MP:0003012 9.95 APOE AQP4 BDNF CASP3 DRD2 IL10
18 respiratory system MP:0005388 9.93 APOE AQP4 BDNF CASP3 COMT DRD2
19 reproductive system MP:0005389 9.91 APOE BDNF CASP3 COMT DRD2 IGF1
20 taste/olfaction MP:0005394 9.43 APOE BDNF CASP3 DRD2 ENO2 MAPT
21 vision/eye MP:0005391 9.32 APOE AQP4 BDNF CASP3 GFAP IL10

Drugs & Therapeutics for Brain Injury

Drugs for Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 617)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
2
Cisatracurium Approved Phase 4 96946-41-7
3
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
4
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
5
Quinidine Approved, Investigational Phase 4 56-54-2 441074
6
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
7
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
8
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
9
Methyltestosterone Approved Phase 4 58-18-4 6010
10
Testosterone enanthate Approved Phase 4 315-37-7 9416
11
Testosterone Approved, Experimental, Investigational Phase 4 481-30-1, 58-22-0 6013 10204
12
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
13
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
14
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
15
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
16
Citalopram Approved Phase 4 59729-33-8 2771
17
Sertraline Approved Phase 4 79617-96-2 68617
18
Fosphenytoin Approved, Investigational Phase 4 93390-81-9 56339
19
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
20
Phenylephrine Approved Phase 4 59-42-7 6041
21
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
22
Simvastatin Approved Phase 4 79902-63-9 54454
23
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
24
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
25
Nicotine Approved Phase 4 54-11-5 942 89594
26
Caffeine Approved Phase 4 58-08-2 2519
27
Ephedrine Approved Phase 4 299-42-3 9294
28
Pseudoephedrine Approved Phase 4 90-82-4 7028
29
Mirtazapine Approved Phase 4 61337-67-5, 85650-52-8 4205
30
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
31
Haloperidol Approved Phase 4 52-86-8 3559
32
Prazosin Approved Phase 4 19216-56-9 4893
33
Sofosbuvir Approved Phase 4 1190307-88-0 45375808
34
Ledipasvir Approved Phase 4 1256388-51-8 67505836
35
Amantadine Approved Phase 4 768-94-5 2130
36
Sargramostim Approved, Investigational Phase 4 83869-56-1, 123774-72-1
37
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
38
Propranolol Approved, Investigational Phase 4 525-66-6 4946
39
Topiramate Approved Phase 4 97240-79-4 5284627
40
Levetiracetam Approved, Investigational Phase 4 102767-28-2 441341
41
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
42
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
43
Prednisolone phosphate Approved, Vet_approved Phase 4 302-25-0
44
Methylprednisolone Approved, Vet_approved Phase 4 83-43-2 6741
45
Methylprednisolone hemisuccinate Approved Phase 4 2921-57-5
46
Prednisolone Approved, Vet_approved Phase 4 50-24-8 5755
47
Clopidogrel Approved Phase 4 113665-84-2, 120202-66-6 60606
48
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
49
Donepezil Approved Phase 4 120014-06-4 3152
50
Amitriptyline Approved Phase 4 50-48-6 2160

Interventional clinical trials:

(show top 50) (show all 2086)
# Name Status NCT ID Phase Drugs
1 Efficacy of Methylphenidate for Management of Long-Term Attention Problems After Pediatric Traumatic Brain Injury (TBI) Unknown status NCT01933217 Phase 4 Methylphenidate;Placebo
2 A Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin in Patients With Traumatic Brain Injury Unknown status NCT01606111 Phase 4 Cerebrolysin;0.9% NaCl, saline
3 Randomized Controlled Clinical Study of Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury Unknown status NCT02161055 Phase 4 Insulin
4 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
5 A Randomised Control Trial to Determine the Effectiveness of Sensory Stimulation Program in Reducing the Length of Time Spent by Severely Brain Injured Patients in a Vegetative State in the Acute Hospital Environment Unknown status NCT00163878 Phase 4
6 Normothermia in Patients With Acute Cerebral Damage Unknown status NCT00491192 Phase 4 Diclofenac
7 A Randomized Controlled Trial of Antidepressant Maintenance for Major Depression Following Mild Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
8 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents. A Controlled Randomized Study Versus Placebo Unknown status NCT02404779 Phase 4 cisatracurium besilate
9 Pilot Study: The Effect of Rozerem on Sleep Disturbance After Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
10 Effects of Intensive Insulin Therapy on Mortality, Morbidity and Long Term Neurologic Outcome in Neurosurgical Intensive Care Patients Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
11 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
12 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
13 Efficiency and Tolerance of a Small-peptide Enteral Feeding Formula Compared to a Whole-protein Formula in the Critically Ill Patient : a Prospective Randomized Trial Unknown status NCT01833624 Phase 4
14 Administration of Tranexamic Acid in the Preclinical Setting and Its Effect on Coagulation Parameters and Outcome in Multiple Trauma Patients and Isolated TBI in EMS (Schutz Und Rettung Zürich) and Helicopter Rescue(REGA). Unknown status NCT02354885 Phase 4 Tranexamic Acid
15 Efficacy of Creative Therapy for Stroke Patients Unknown status NCT01455155 Phase 4
16 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
17 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
18 The Use of Low Molecular Weight Heparin in Traumatic Brain Injury Completed NCT00170378 Phase 4 Enoxaparin
19 Pharmacological Intervention in Depression After Traumatic Brain Injury (A Research Study Within the Traumatic Brain Injury Model System) Completed NCT00205491 Phase 4 Venlafaxine
20 A 26-Week Open-Label Extension to Protocol No. CENA713BUS11: A 12-Week, Prospective, Double-blind, Placebo-controlled, Multi-center Study Evaluating the Efficacy and Safety of Rivastigmine 3 to 6 mg/Day in Patients With Traumatic Brain Injury (TBI) With Persistent Cognitive Deficits Completed NCT00219245 Phase 4 Rivastigmine
21 Intravenous Exenatide Infusion in Critically Ill Patients With Acute Brain Injury Completed NCT02058940 Phase 4 Exenatide
22 Improvement of Therapy in Patients With Severe Traumatic Brain Injury: Differential Impact of Local and Systemic Changes and Routinely Applied Drugs Completed NCT02130674 Phase 4 Dipeptiven
23 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed NCT00957671 Phase 4 Recombinant human growth hormone
24 Effect of Erythropoietin on Preterm Brain Injury Completed NCT02036073 Phase 4 recombinant human erythropoietin
25 Beta-Adrenergic Blockade for Suppression of Catecholamine Surge Following Traumatic Brain Injury: A Randomized Trial Completed NCT02957331 Phase 4 Propranolol
26 Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI Completed NCT01750268 Phase 4 Topiramate;Placebo
27 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon: A Prospective Randomized Clinical Trial Injury to Reduce Sympathetic Storm Phenomenon: A Prospective Randomized Clinical Trial Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
28 Equimolar Doses of Mannitol and Hypertonic Saline in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4 20% mannitol;7.45% hypertonic saline solution
29 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
30 Simvastatin: Proof-of-Concept for Prevention of Neurodegeneration in Mild TBI Completed NCT01952288 Phase 4 simvastatin;Placebo Oral Tablet
31 Assessment of Seizure Prophylaxis Protocols Using Intravenous Levetiracetam in a Neuroscience Intensive Care Unit Completed NCT00618436 Phase 4 Levetiracetam;Phenytoin
32 A Study to Assess the Safety, Tolerability and Effectiveness of Nuedexta (Dextromethorphan 20 mg/Quinidine 10 mg) in the Treatment of Pseudobulbar Affect (PBA) Completed NCT01799941 Phase 4 Nuedexta (DM 20 mg/Q 10 mg)
33 Amantadine Hydrochloride for Treatment of Symptoms of the Post-traumatic Confusional State Among Neurorehabilitation Admissions With TBI: A Randomized, Double-Blind, Placebo-Controlled Trial Completed NCT00693121 Phase 4 Amantadine hydrochloride;Placebo capsule
34 Phase IV Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury Completed NCT01339806 Phase 4
35 The Control of Brain Networks After Traumatic Brain Injury: a Neuroimaging and Neuropsychological Study of Dopamine and Cognition Completed NCT02015949 Phase 4 Methylphenidate;Placebo
36 The Serotonin Transporter Gene Polymorphism and Major Depression Following Traumatic Brain Injury Completed NCT00254007 Phase 4 citalopram (celexa)
37 Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery Completed NCT00035139 Phase 4 methylphenidate
38 Abobotulinumtoxina Efficacy in Post-Traumatic Headache Completed NCT03928496 Phase 4 AbobotulinumtoxinA;Normal saline
39 Bispectral Index Value Changes During Induction and Surgical Decompression in Head Injury Patients Completed NCT03480880 Phase 4
40 Micronized Oral Progesterone and Effect on Time Symptomatic From Concussion: A Pilot Study Completed NCT01809639 Phase 4 Progesterone;Placebo
41 Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity Completed NCT00178646 Phase 4 Botox
42 Magnetic Resonance Imaging and Neurodevelopmental Outcomes in Preterm Infants Following Administration of High-Dose Caffeine - A Pilot Study Completed NCT00809055 Phase 4 Caffeine citrate
43 Clinical Interest of Endovascular Cooling in the Management of Cardiac Arrest: Impact on Mortality in a Randomized Medico-economical Trial (the ICEREA Study) Completed NCT00392639 Phase 4
44 An Open-Label Trial of Memantine for Cognitive Impairment in Patients With Post-Traumatic Stress Disorder Completed NCT02258828 Phase 4 Memantine
45 Progesterone Augmentation of Nicotine Replacement Therapy Study Completed NCT02685072 Phase 4 Progesterone (200 mgs BID);Placebo
46 The Effect of Amantadine on Movement Disorder in Ataxia-Telangiectasia Completed NCT00950196 Phase 4 amantadine sulphate
47 Combined Mirtazapine and Selective Serotonin Reuptake Inhibitor (SSRI) Treatment of Post-traumatic Stress Disorder (PTSD) Completed NCT01178671 Phase 4 Mirtazapine;Sertraline
48 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients. PILOT: The TRAUMOX Trial Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
49 Dexmedetomidine Addition to Benzodiazepines for Patients With Alcohol Withdrawal Syndrome in the ICU: a Randomised Controlled Study Completed NCT02496650 Phase 4 Dexmedetomidine
50 The Effect of Two Different Rates of Nitroglycerin Infusion on Cerebral Rewarming During Rewarming Period of Hypothermic Cardiopulmonary Bypass Completed NCT03251599 Phase 4 Glyceryl trinitrate 0.2;Glyceryl trinitrate 0.5

Search NIH Clinical Center for Brain Injury

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Injury:
Hematopoietic stem cells for treatment of ischemic brain injury
Embryonic/Adult Cultured Cells Related to Brain Injury:
Bone marrow-derived hematopoietic stem cells (family)

Genetic Tests for Brain Injury

Anatomical Context for Brain Injury

MalaCards organs/tissues related to Brain Injury:

41
Brain, Testes, Heart, Bone, Cortex, Spinal Cord, Eye

Publications for Brain Injury

Articles related to Brain Injury:

(show top 50) (show all 30000)
# Title Authors PMID Year
1
Aquaporin4 Knockout Aggravates Early Brain Injury Following Subarachnoid Hemorrhage Through Impairment of the Glymphatic System in Rat Brain. 38
31407064 2020
2
Nox2 and Nox4 Participate in ROS-Induced Neuronal Apoptosis and Brain Injury During Ischemia-Reperfusion in Rats. 38
31407062 2020
3
The PERK Pathway Plays a Neuroprotective Role During the Early Phase of Secondary Brain Injury Induced by Experimental Intracerebral Hemorrhage. 38
31407071 2020
4
GINS complex subunit 2 (GINS2) plays a protective role in alcohol-induced brain injury. 38
30513217 2019
5
Parenting and the dysregulation profile predict executive functioning in children with acquired brain injury. 38
30890030 2019
6
MK-801 attenuates lesion expansion following acute brain injury in rats: a meta-analysis. 38
31290450 2019
7
Reduced avoidance coping in male, but not in female rats, after mild traumatic brain injury: Implications for depression. 38
31278968 2019
8
Human neural stem cell transplants to address multiple pathologies associated with traumatic brain injury. 38
31169178 2019
9
Collagen-chitosan scaffold impregnated with bone marrow mesenchymal stem cells for treatment of traumatic brain injury. 38
31169196 2019
10
Modeling sports-related mild traumatic brain injury in animals-A systematic review. 38
31135069 2019
11
Predicting long-term cognitive and neuropathological consequences of moderate to severe traumatic brain injury: Review and theoretical framework. 38
31156042 2019
12
Resveratrol reduces brain injury after subarachnoid hemorrhage by inhibiting oxidative stress and endoplasmic reticulum stress. 38
31169191 2019
13
Differences in pathological changes between two rat models of severe traumatic brain injury. 38
31169198 2019
14
(-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice. 38
31295555 2019
15
Vascular endothelial growth factor A promotes platelet adhesion to collagen IV and causes early brain injury after subarachnoid hemorrhage. 38
31169190 2019
16
Visualization of thalamic calcium influx with quantitative susceptibility mapping as a potential imaging biomarker for repeated mild traumatic brain injury. 38
31201986 2019
17
Emerging advances of in vivo detection of chronic traumatic encephalopathy and traumatic brain injury. 38
31287716 2019
18
The association between attention deficit hyperactivity disorder severity and risk of mild traumatic brain injury in children with attention deficit hyperactivity disorder in the United States of America: A cross-sectional study of data from the National Survey of Children with Special Health Care Needs. 38
31049988 2019
19
Prehospital Versus Trauma Center Glasgow Coma Scale in Pediatric Traumatic Brain Injury Patients. 38
31022676 2019
20
Mild traumatic brain injury characteristics do not negatively influence cognitive processing therapy attendance or outcomes. 38
31174014 2019
21
Postoperative cerebral oxygenation was not associated with new brain injury in infants with congenital heart disease. 38
30982585 2019
22
Neurodevelopmental outcomes at 9-14 months gestational age after treatment of neonatal seizures due to brain injury. 38
31278442 2019
23
Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats. 38
31410103 2019
24
Using computerized tomography perfusion to measure cerebral hemodynamics following treatment of traumatic brain injury in rabbits. 38
31410165 2019
25
Dexmedetomidine reduces inflammation in traumatic brain injury by regulating the inflammatory responses of macrophages and splenocytes. 38
31410183 2019
26
How do you treat traumatic brain injury? One symptom at a time. 38
31206780 2019
27
Borneol alleviates brain injury in sepsis mice by blocking neuronal effect of endotoxin. 38
31301416 2019
28
The dynamic nature of the sense of ownership after brain injury. Clues from asomatognosia and somatoparaphrenia. 38
31194981 2019
29
Downregulated lncRNA CRNDE contributes to the enhancement of nerve repair after traumatic brain injury in rats. 38
31345079 2019
30
ERPs predict symptomatic distress and recovery in sub-acute mild traumatic brain injury. 38
31228481 2019
31
Salvinorin A attenuates early brain injury through PI3K/Akt pathway after subarachnoid hemorrhage in rat. 38
31125530 2019
32
Vision rehabilitation interventions following mild traumatic brain injury: a scoping review. 38
29631511 2019
33
Motivation in rehabilitation and acquired brain injury: can theory help us understand it? 38
29693464 2019
34
Monitoring traumatic brain injury in China. 38
31397282 2019
35
Associations between brain drawings following mild traumatic brain injury and negative illness perceptions and post-concussion symptoms at 4 years. 38
31394985 2019
36
Variables associated with subjective cognitive change among Iraq and Afghanistan war Veterans with blast-related mild traumatic brain injury. 38
31106695 2019
37
Functional improvement after severe brain injury with disorder of consciousness paralleling treatment for comorbid obstructive sleep apnoea: a case report. 38
31283551 2019
38
Classification accuracy of individual and combined executive functioning embedded performance validity measures in mild traumatic brain injury. 38
29521533 2019
39
The Role of Mitochondrial and Endoplasmic Reticulum Reactive Oxygen Species Production in Models of Perinatal Brain Injury. 38
30957515 2019
40
Altered neonatal white and gray matter microstructure is associated with neurodevelopmental impairments in very preterm infants with high-grade brain injury. 38
31212303 2019
41
RIP3 participates in early brain injury after experimental subarachnoid hemorrhage in rats by inducing necroptosis. 38
31082470 2019
42
MMPI-2-RF patterns after traumatic brain injury. 38
31219277 2019
43
Functional Outcomes 6 Months After Severe Traumatic Brain Injury Following Admission Into Intensive Care Unit: A Cohort Study in Two Tertiary Hospitals. 38
29618232 2019
44
Effect of HMGB1 and RAGE on brain injury and the protective mechanism of glycyrrhizin in intracranial‑sinus occlusion followed by mechanical thrombectomy recanalization. 38
31257456 2019
45
The added prognostic value of magnetic resonance imaging in traumatic brain injury: The importance of traumatic axonal injury when performing ordinal logistic regression. 38
30179689 2019
46
We are not the same people we used to be: An exploration of family biographical narratives and identity change following traumatic brain injury. 38
29070000 2019
47
Therapeutic hypothermia initiated within 6 hours of birth is associated with reduced brain injury on MR biomarkers in mild hypoxic-ischaemic encephalopathy: a non-randomised cohort study. 38
30425113 2019
48
Rhodiola crenulata attenuates apoptosis and mitochondrial energy metabolism disorder in rats with hypobaric hypoxia-induced brain injury by regulating the HIF-1α/microRNA 210/ISCU1/2(COX10) signaling pathway. 38
30878546 2019
49
Decompressive craniectomy for severe traumatic brain injury in children: analysis of long-term neuropsychological impairment and review of the literature. 38
31264065 2019
50
The Role of Intracranial Pressure and Subarachnoid Blood Clots in Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats. 38
31100532 2019

Variations for Brain Injury

Expression for Brain Injury

Search GEO for disease gene expression data for Brain Injury.

Pathways for Brain Injury

GO Terms for Brain Injury

Cellular components related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.72 MAPT DRD2 COMT BDNF APOE
2 axon GO:0030424 9.65 UCHL1 MAPT DRD2 COMT BDNF
3 glial cell projection GO:0097386 9.37 MAPT GFAP
4 cell body GO:0044297 9.26 MAPT GFAP EPO COMT
5 neuronal cell body GO:0043025 9.17 UCHL1 S100B MBP MAPT ENO2 CASP3
6 myelin sheath GO:0043209 8.85 MBP
7 extracellular region GO:0005576 10.06 SPTAN1 S100B MAPT IL6 IL10 IGF1
8 extracellular space GO:0005615 10.03 S100B IL6 IL10 IGF1 EPO ENO2

Biological processes related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axonogenesis GO:0007409 9.63 UCHL1 S100B DRD2
2 response to lipopolysaccharide GO:0032496 9.62 IL10 EPO COMT CASP3
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.54 IL6 IGF1 EPO
4 dopamine metabolic process GO:0042417 9.48 DRD2 COMT
5 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.43 MBP IL10
6 long-term synaptic potentiation GO:0060291 9.43 SLC24A2 S100B GFAP
7 axonal transport of mitochondrion GO:0019896 9.4 UCHL1 MAPT
8 response to glucocorticoid GO:0051384 9.26 S100B IL6 IL10 CASP3
9 response to inactivity GO:0014854 9.16 IL10 DRD2
10 memory GO:0007613 9.02 SLC24A2 S100B MAPT BDNF ASIC1

Molecular functions related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipoprotein particle binding GO:0071813 8.96 MAPT APOE
2 growth factor activity GO:0008083 8.92 IL6 IL10 IGF1 BDNF
3 protein binding GO:0005515 10.09 UCHL1 SPTAN1 S100B MBP MAPT IL6

Sources for Brain Injury

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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