Brain Injury

Categories: Neuronal diseases

Aliases & Classifications for Brain Injury

MalaCards integrated aliases for Brain Injury:

Name: Brain Injury 53 37


Summaries for Brain Injury

NINDS : 53 Traumatic brain injury (TBI), a form of acquired brain injury, occurs when a sudden trauma causes damage to the brain. TBI can result when the head suddenly and violently hits an object, or when an object pierces the skull and enters brain tissue.  Symptoms of a TBI can be mild, moderate, or severe, depending on the extent of the damage to the brain. A person with a mild TBI may remain conscious or may experience a loss of consciousness for a few seconds or minutes. Other symptoms of mild TBI include headache, confusion, lightheadedness, dizziness, blurred vision or tired eyes, ringing in the ears, bad taste in the mouth, fatigue or lethargy, a change in sleep patterns, behavioral or mood changes, and trouble with memory, concentration, attention, or thinking.  A person with a moderate or severe TBI may show these same symptoms, but may also have a headache that gets worse or does not go away, repeated vomiting or nausea, convulsions or seizures, an inability to awaken from sleep, dilation of one or both pupils of the eyes, slurred speech, weakness or numbness in the extremities, loss of coordination, and increased confusion, restlessness, or agitation.

MalaCards based summary : Brain Injury is related to neonatal hypoxic and ischemic brain injury and head injury. An important gene associated with Brain Injury is TMEM158 (Transmembrane Protein 158 (Gene/Pseudogene)), and among its related pathways/superpathways are JAK-STAT signaling pathway (KEGG) and Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways. The drugs Diclofenac and Cisatracurium have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart, and related phenotypes are Decreased viability with paclitaxel and Decreased viability with paclitaxel

Related Diseases for Brain Injury

Diseases related to Brain Injury via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 986)
# Related Disease Score Top Affiliating Genes
1 neonatal hypoxic and ischemic brain injury 34.4 MBP ENO2 BDNF
2 head injury 33.5 S100B ENO2 APOE
3 persistent vegetative state 32.9 ENO2 APOE
4 periventricular leukomalacia 32.7 MBP IL6 EPO
5 post-cardiac arrest syndrome 32.5 S100B IL6 ENO2
6 cerebral hypoxia 32.4 IGF1 CASP3
7 aphasia 32.1 MAPT BDNF APOE
8 cerebral artery occlusion 31.7 BDNF AQP4 APOE
9 amnestic disorder 31.7 S100B DRD2 BDNF APOE
10 cardiac arrest 31.6 S100B EPO ENO2 APOE
11 brain edema 31.4 IL6 GFAP AQP4
12 obsessive-compulsive disorder 31.3 IL6 IGF1 DRD2 COMT BDNF APOE
13 post-traumatic stress disorder 31.1 DRD2 COMT BDNF APOE
14 normal pressure hydrocephalus 31.0 MAPT IGF1 GFAP BDNF AQP4 APOE
15 speech and communication disorders 30.9 MAPT IL6 DRD2 COMT BDNF APOE
16 status epilepticus 30.9 GFAP ENO2 CASP3 BDNF
17 spinal cord injury 30.7 IL6 GFAP CASP3 BDNF AQP4
18 asphyxia neonatorum 30.7 S100B EPO ENO2 CASP3
19 dementia 30.7 UCHL1 MAPT GFAP DRD2 COMT BDNF
20 mental depression 30.6 IL6 DRD2 COMT BDNF
21 personality disorder 30.5 DRD2 COMT BDNF
22 epilepsy 30.5 SPTAN1 S100B MAPT IGF1 GFAP BDNF
23 anxiety 30.5 IL6 DRD2 COMT BDNF APOE
24 generalized anxiety disorder 30.5 DRD2 COMT BDNF
25 mood disorder 30.4 IL6 GFAP DRD2 COMT BDNF
26 cerebral palsy 30.4 S100B IL6 IL10 IGF1 BDNF APOE
27 alexithymia 30.4 IL6 DRD2 COMT
28 psychotic disorder 30.3 S100B DRD2 COMT BDNF
29 obstructive hydrocephalus 30.3 GFAP ENO2 AQP4
30 migraine with or without aura 1 30.3 IL6 DRD2 COMT BDNF
31 chiari malformation 30.2 MBP GFAP
32 meningitis 30.2 S100B IL6 IL10 AQP4
33 fetal alcohol syndrome 30.1 GFAP CASP3 BDNF
34 sleep disorder 30.1 MAPT IL6 IGF1 DRD2 BDNF
35 ganglioglioma 30.0 S100B GFAP ENO2
36 bacterial meningitis 30.0 S100B IL6 IL10 AQP4
37 traumatic brain injury 30.0 UCHL1 SPTAN1 S100B MBP IL6 IL10
38 benign ependymoma 29.9 S100B GFAP ENO2
39 juvenile pilocytic astrocytoma 29.9 TMEM158 S100B GFAP
40 panic disorder 29.9 DRD2 COMT BDNF ASIC1
41 tuberous sclerosis 29.9 S100B IGF1 GFAP ENO2
42 peripheral artery disease 29.8 IL6 IGF1 APOE
43 akinetic mutism 29.8 S100B MBP MAPT ENO2
44 endogenous depression 29.8 IL6 COMT BDNF
45 encephalitis 29.8 IL6 IL10 GFAP AQP4
46 sleep apnea 29.8 IL6 IL10 IGF1 EPO BDNF APOE
47 borderline personality disorder 29.8 DRD2 COMT BDNF
48 oligodendroglioma 29.8 S100B MBP GFAP ENO2
49 encephalomalacia 29.8 S100B MBP IL6 GFAP EPO CASP3
50 apnea, obstructive sleep 29.7 IL6 IGF1 APOE

Graphical network of the top 20 diseases related to Brain Injury:

Diseases related to Brain Injury

Symptoms & Phenotypes for Brain Injury

GenomeRNAi Phenotypes related to Brain Injury according to GeneCards Suite gene sharing:

# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability with paclitaxel GR00179-A-1 8.92 CASP3 IGF1 IL10
2 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1

MGI Mouse Phenotypes related to Brain Injury:

45 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.49 APOE AQP4 ASIC1 BDNF CASP3 COMT
2 homeostasis/metabolism MP:0005376 10.41 APOE AQP4 BDNF CASP3 COMT DRD2
3 cardiovascular system MP:0005385 10.4 APOE AQP4 CASP3 COMT DRD2 EPO
4 cellular MP:0005384 10.39 APOE BDNF CASP3 DRD2 ENO2 EPO
5 growth/size/body region MP:0005378 10.39 APOE AQP4 BDNF CASP3 DRD2 ENO2
6 nervous system MP:0003631 10.33 APOE AQP4 ASIC1 BDNF CASP3 COMT
7 hematopoietic system MP:0005397 10.3 APOE AQP4 CASP3 COMT DRD2 EPO
8 mortality/aging MP:0010768 10.3 APOE AQP4 BDNF CASP3 DRD2 EPO
9 immune system MP:0005387 10.27 APOE AQP4 CASP3 COMT DRD2 EPO
10 digestive/alimentary MP:0005381 10.22 APOE AQP4 BDNF CASP3 DRD2 GFAP
11 integument MP:0010771 10.22 APOE BDNF CASP3 DRD2 EPO IGF1
12 endocrine/exocrine gland MP:0005379 10.21 APOE AQP4 BDNF CASP3 COMT DRD2
13 muscle MP:0005369 10.09 APOE CASP3 DRD2 EPO GFAP IGF1
14 normal MP:0002873 10.02 BDNF DRD2 EPO GFAP IGF1 IL10
15 hearing/vestibular/ear MP:0005377 10.01 APOE AQP4 BDNF CASP3 IGF1 MBP
16 respiratory system MP:0005388 9.93 APOE AQP4 BDNF CASP3 COMT DRD2
17 no phenotypic analysis MP:0003012 9.91 APOE AQP4 BDNF CASP3 DRD2 IL10
18 renal/urinary system MP:0005367 9.91 APOE AQP4 CASP3 COMT DRD2 IGF1
19 taste/olfaction MP:0005394 9.43 APOE BDNF CASP3 DRD2 ENO2 MAPT
20 vision/eye MP:0005391 9.32 APOE AQP4 BDNF CASP3 GFAP IL10

Drugs & Therapeutics for Brain Injury

Drugs for Brain Injury (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 593)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
Cisatracurium Approved Phase 4 96946-41-7
Atracurium Approved, Experimental, Investigational Phase 4 64228-79-1 47319
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
Quinidine Approved, Investigational Phase 4 56-54-2 441074
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 68602 5311068
Exenatide Approved, Investigational Phase 4 141758-74-9 15991534
Methyltestosterone Approved Phase 4 58-18-4 6010
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 6013 10204
Testosterone undecanoate Approved, Investigational Phase 4 5949-44-0
Testosterone enanthate Approved Phase 4 315-37-7 9416
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Phenytoin Approved, Vet_approved Phase 4 57-41-0 1775
Thiopental Approved, Vet_approved Phase 4 76-75-5 3000715
Citalopram Approved Phase 4 59729-33-8 2771
Sertraline Approved Phase 4 79617-96-2 68617
Fosphenytoin Approved, Investigational Phase 4 93390-81-9 56339
Phenylephrine Approved Phase 4 59-42-7 6041
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
Simvastatin Approved Phase 4 79902-63-9 54454
Dextromethorphan Approved Phase 4 125-71-3 5360696 5362449
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Nicotine Approved Phase 4 54-11-5 942 89594
Caffeine Approved Phase 4 58-08-2 2519
Haloperidol Approved Phase 4 52-86-8 3559
Diazepam Approved, Illicit, Investigational, Vet_approved Phase 4 439-14-5 3016
Mirtazapine Approved Phase 4 85650-52-8, 61337-67-5 4205
Histamine Approved, Investigational Phase 4 51-45-6 774
Pseudoephedrine Approved Phase 4 90-82-4 7028
Ephedrine Approved Phase 4 299-42-3 9294
Amantadine Approved Phase 4 768-94-5 2130
Prazosin Approved Phase 4 19216-56-9 4893
Sargramostim Approved, Investigational Phase 4 123774-72-1, 83869-56-1
Rivastigmine Approved, Investigational Phase 4 123441-03-2 77991
Propranolol Approved, Investigational Phase 4 525-66-6 4946
Topiramate Approved Phase 4 97240-79-4 5284627
Levetiracetam Approved Phase 4 102767-28-2 441341
Valproic acid Approved, Investigational Phase 4 99-66-1 3121
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
Clopidogrel Approved Phase 4 120202-66-6, 113665-84-2 60606
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
Donepezil Approved Phase 4 120014-06-4 3152
Rotigotine Approved Phase 4 99755-59-6, 92206-54-7 57537
Pramipexole Approved, Investigational Phase 4 104632-26-0 59868 119570
Rizatriptan Approved Phase 4 144034-80-0, 145202-66-0 5078
Pregabalin Approved, Investigational Phase 4 148553-50-8 5486971
Amitriptyline Approved Phase 4 50-48-6 2160
Zolmitriptan Approved, Investigational Phase 4 139264-17-8 441240 60857
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994

Interventional clinical trials:

(show top 50) (show all 2162)
# Name Status NCT ID Phase Drugs
1 Efficacy of Methylphenidate for Management of Long-Term Attention Problems After Pediatric Traumatic Brain Injury (TBI) Unknown status NCT01933217 Phase 4 Methylphenidate;Placebo
2 A Randomized, Double-blind, Placebo-controlled Trial to Investigate Safety and Efficacy of Cerebrolysin in Patients With Traumatic Brain Injury Unknown status NCT01606111 Phase 4 Cerebrolysin;0.9% NaCl, saline
3 Randomized Controlled Clinical Study of Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury Unknown status NCT02161055 Phase 4 Insulin
4 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
5 Normothermia in Patients With Acute Cerebral Damage Unknown status NCT00491192 Phase 4 Diclofenac
6 A Randomised Control Trial to Determine the Effectiveness of Sensory Stimulation Program in Reducing the Length of Time Spent by Severely Brain Injured Patients in a Vegetative State in the Acute Hospital Environment Unknown status NCT00163878 Phase 4
7 A Randomized Controlled Trial of Antidepressant Maintenance for Major Depression Following Mild Traumatic Brain Injury Unknown status NCT00162916 Phase 4 citalopram;Placebo
8 Treatment of Intracranial Hypertension of Severe Tramatic Brain Injured Patients. Physiopathologic Effects of Neuromuscular Blocking Agents. A Controlled Randomized Study Versus Placebo Unknown status NCT02404779 Phase 4 cisatracurium besilate
9 Pilot Study: The Effect of Rozerem on Sleep Disturbance After Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
10 Effects of Intensive Insulin Therapy on Mortality, Morbidity and Long Term Neurologic Outcome in Neurosurgical Intensive Care Patients Unknown status NCT00505505 Phase 4 Insulin (Actrapid)
11 Citicholine-Amantadine Trial in Traumatic Brain Injury Unknown status NCT03430817 Phase 4 Citicholine;Amantadine
12 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
13 The Benefit of Prophylactic Anticonvulsant in Post Cardiac Arrest Syndrome With Induced Mild Hypothermia Unknown status NCT01083784 Phase 4 Use of prophylactic anticonvulsants (valproate, clonazepam);Control group
14 Efficiency and Tolerance of a Small-peptide Enteral Feeding Formula Compared to a Whole-protein Formula in the Critically Ill Patient : a Prospective Randomized Trial Unknown status NCT01833624 Phase 4
15 Administration of Tranexamic Acid in the Preclinical Setting and Its Effect on Coagulation Parameters and Outcome in Multiple Trauma Patients and Isolated TBI in EMS (Schutz Und Rettung Zürich) and Helicopter Rescue(REGA). Unknown status NCT02354885 Phase 4 Tranexamic Acid
16 Efficacy of Creative Therapy for Stroke Patients Unknown status NCT01455155 Phase 4
17 Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass Unknown status NCT00297245 Phase 4 cognitive function
18 Does Discontinuation of Aspirin Treatment Following Head Trauma Decrease the Incidence of Chronic Subdural Hematoma? Unknown status NCT01470040 Phase 4 discontinuation of aspirin therapy;continuation of aspirin therapy
19 The Use of Low Molecular Weight Heparin in Traumatic Brain Injury Completed NCT00170378 Phase 4 Enoxaparin
20 Pharmacological Intervention in Depression After Traumatic Brain Injury (A Research Study Within the Traumatic Brain Injury Model System) Completed NCT00205491 Phase 4 Venlafaxine
21 A 26-Week Open-Label Extension to Protocol No. CENA713BUS11: A 12-Week, Prospective, Double-blind, Placebo-controlled, Multi-center Study Evaluating the Efficacy and Safety of Rivastigmine 3 to 6 mg/Day in Patients With Traumatic Brain Injury (TBI) With Persistent Cognitive Deficits Completed NCT00219245 Phase 4 Rivastigmine
22 Intravenous Exenatide Infusion in Critically Ill Patients With Acute Brain Injury Completed NCT02058940 Phase 4 Exenatide
23 Improvement of Therapy in Patients With Severe Traumatic Brain Injury: Differential Impact of Local and Systemic Changes and Routinely Applied Drugs Completed NCT02130674 Phase 4 Dipeptiven
24 Anterior Pituitary Hormone Replacement in Traumatic Brain Injury Completed NCT00957671 Phase 4 Recombinant human growth hormone
25 Treatment Outcomes With Lisdexamfetamine Dimesylate (Vyvanse) in Children With Traumatic Brain Injury-Related Attention Deficits Completed NCT02712996 Phase 4 Lisdexamfetamine;Placebo
26 Effect of Erythropoietin on Preterm Brain Injury Completed NCT02036073 Phase 4 recombinant human erythropoietin
27 Beta-Adrenergic Blockade for Suppression of Catecholamine Surge Following Traumatic Brain Injury: A Randomized Trial Completed NCT02957331 Phase 4 Propranolol
28 Topiramate Treatment of Hazardous and Harmful Alcohol Use in Veterans With TBI Completed NCT01750268 Phase 4 Topiramate;Placebo
29 Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon: A Prospective Randomized Clinical Trial Injury to Reduce Sympathetic Storm Phenomenon: A Prospective Randomized Clinical Trial Completed NCT03401515 Phase 4 Propranolol Hydrochloride 1 MG/ML
30 Equimolar Doses of Mannitol and Hypertonic Saline in the Treatment of Elevated Intracranial Pressure Completed NCT00447018 Phase 4 20% mannitol;7.45% hypertonic saline solution
31 Neuroendocrine Dysfunction in Traumatic Brain Injury: Effects of Testosterone Therapy Completed NCT01201863 Phase 4 Androgel (Testosterone Gel);Androgel Placebo
32 Simvastatin: Proof-of-Concept for Prevention of Neurodegeneration in Mild TBI Completed NCT01952288 Phase 4 simvastatin;Placebo Oral Tablet
33 A Study to Assess the Safety, Tolerability and Effectiveness of Nuedexta (Dextromethorphan 20 mg/Quinidine 10 mg) in the Treatment of Pseudobulbar Affect (PBA) Completed NCT01799941 Phase 4 Nuedexta (DM 20 mg/Q 10 mg)
34 Assessment of Seizure Prophylaxis Protocols Using Intravenous Levetiracetam in a Neuroscience Intensive Care Unit Completed NCT00618436 Phase 4 Levetiracetam;Phenytoin
35 Phase IV Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury Completed NCT01339806 Phase 4
36 Amantadine Hydrochloride for Treatment of Symptoms of the Post-traumatic Confusional State Among Neurorehabilitation Admissions With TBI: A Randomized, Double-Blind, Placebo-Controlled Trial Completed NCT00693121 Phase 4 Amantadine hydrochloride;Placebo capsule
37 The Serotonin Transporter Gene Polymorphism and Major Depression Following Traumatic Brain Injury Completed NCT00254007 Phase 4 citalopram (celexa)
38 The Control of Brain Networks After Traumatic Brain Injury: a Neuroimaging and Neuropsychological Study of Dopamine and Cognition Completed NCT02015949 Phase 4 Methylphenidate;Placebo
39 Pediatric Traumatic Brain Injury: Methylphenidate Effects on Early Recovery Completed NCT00035139 Phase 4 methylphenidate
40 Bispectral Index Value Changes During Induction and Surgical Decompression in Head Injury Patients Completed NCT03480880 Phase 4
41 Abobotulinumtoxina Efficacy in Post-Traumatic Headache Completed NCT03928496 Phase 4 AbobotulinumtoxinA;Normal saline
42 Micronized Oral Progesterone and Effect on Time Symptomatic From Concussion: A Pilot Study Completed NCT01809639 Phase 4 Progesterone;Placebo
43 Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity Completed NCT00178646 Phase 4 Botox
44 Magnetic Resonance Imaging and Neurodevelopmental Outcomes in Preterm Infants Following Administration of High-Dose Caffeine - A Pilot Study Completed NCT00809055 Phase 4 Caffeine citrate
45 Clinical Interest of Endovascular Cooling in the Management of Cardiac Arrest: Impact on Mortality in a Randomized Medico-economical Trial (the ICEREA Study) Completed NCT00392639 Phase 4
46 An Open-Label Trial of Memantine for Cognitive Impairment in Patients With Post-Traumatic Stress Disorder Completed NCT02258828 Phase 4 Memantine
47 The Effect of Amantadine on Movement Disorder in Ataxia-Telangiectasia Completed NCT00950196 Phase 4 amantadine sulphate
48 Progesterone Augmentation of Nicotine Replacement Therapy Study Completed NCT02685072 Phase 4 Progesterone (200 mgs BID);Placebo
49 Restrictive vs. Liberal Oxygen Therapy for Trauma Patients. PILOT: The TRAUMOX Trial Completed NCT03491644 Phase 4 Titrated Oxygen;Liberal Oxygen
50 The Effect of Two Different Rates of Nitroglycerin Infusion on Cerebral Rewarming During Rewarming Period of Hypothermic Cardiopulmonary Bypass Completed NCT03251599 Phase 4 Glyceryl trinitrate 0.2;Glyceryl trinitrate 0.5

Search NIH Clinical Center for Brain Injury

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Injury cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Injury:
Hematopoietic stem cells for treatment of ischemic brain injury
Embryonic/Adult Cultured Cells Related to Brain Injury:
Bone marrow-derived hematopoietic stem cells (family)

Genetic Tests for Brain Injury

Anatomical Context for Brain Injury

MalaCards organs/tissues related to Brain Injury:

Brain, Testes, Heart, Bone, Pituitary, Cortex, Spinal Cord

Publications for Brain Injury

Articles related to Brain Injury:

(show top 50) (show all 30000)
# Title Authors PMID Year
Moderate/severe traumatic brain injury as a trigger of chronic neurodegeneration in humans. 61
31960805 2020
Risk factors for corticosteroid insufficiency during the sub-acute phase of acute traumatic brain injury. 61
31960811 2020
Fast-tracking regenerative medicine for traumatic brain injury. 61
31960797 2020
Exosome-mediated crosstalk between microglia and neural stem cells in the repair of brain injury. 61
31823874 2020
The extended renin-angiotensin system: a promising target for traumatic brain injury therapeutics. 61
31823875 2020
Remote ischemic conditioning improves outcome independent of anesthetic effects following shockwave-induced traumatic brain injury. 61
31909289 2020
Caffeine consumption during development alters spine density and recovery from repetitive mild traumatic brain injury in young adult rats. 61
31705690 2020
Inhibiting endogenous tissue plasminogen activator enhanced neuronal apoptosis and axonal injury after traumatic brain injury. 61
31638090 2020
Management of Paroxysmal Sympathetic Hyperactivity with Dexmedetomidine and Propranolol Following Traumatic Brain Injury in a Pediatric Patient. 61
31984161 2020
The assessment of the peak of reflex cough in subjects with acquired brain injury and tracheostomy and healthy controls. 61
31899352 2020
Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model. 61
31904409 2020
Effect of eye movement reactivation on visual memory among individuals with moderate-to-severe traumatic brain injury (TBI). 61
31847796 2020
A novel mouse model for the study of endogenous neural stem and progenitor cells after traumatic brain injury. 61
31751572 2020
Greater neurodegeneration and behavioral deficits after single closed head traumatic brain injury in adolescent versus adult male mice. 61
31541497 2020
miR‑222 regulates brain injury and inflammation following intracerebral hemorrhage by targeting ITGB8. 61
31894320 2020
Role of quetiapine in protection of neurodegeneration after traumatic brain injury. 61
30913942 2020
Phycocyanobilin reduces brain injury after endothelin-1- induced focal cerebral ischaemia. 61
31732975 2020
Sustained neuronal and microglial alterations are associated with diverse neurobehavioral dysfunction long after experimental brain injury. 61
31843705 2020
Posttraumatic Stress Disorder, Traumatic Brain Injury, Sleep, and Performance in Military Personnel. 61
32005353 2020
Traumatic Brain Injury: An Overview of Epidemiology, Pathophysiology, and Medical Management. 61
32035565 2020
Neuroprotection of Cyperus esculentus L. orientin against cerebral ischemia/reperfusion induced brain injury. 61
31571667 2020
Intranasal wnt-3a alleviates neuronal apoptosis in early brain injury post subarachnoid hemorrhage via the regulation of wnt target PPAN mediated by the moonlighting role of aldolase C. 61
31899197 2020
Adiponectin reduces brain injury after intracerebral hemorrhage by reducing NLRP3 inflammasome expression. 61
31607194 2020
Juvenile mild traumatic brain injury elicits distinct spatiotemporal astrocyte responses. 61
31670865 2020
Modulation of autophagy in traumatic brain injury. 61
31512236 2020
Altered resting-state functional connectivity within the developing social brain after pediatric traumatic brain injury. 61
31617298 2020
Optimized Sleep After Brain Injury (OSABI): A Pilot Study of a Sleep Hygiene Intervention for Individuals With Moderate to Severe Traumatic Brain Injury. 61
31884895 2020
Could Neurotracker be used as a clinical marker of recovery following pediatric mild traumatic brain injury? An exploratory study. 61
32013583 2020
Influence of Blood-Brain Barrier Integrity on Brain Protein Biomarker Clearance in Severe Traumatic Brain Injury: A Longitudinal Prospective Study. 61
32013731 2020
Alterations in Peripheral Organs following Combined Hypoxemia and Hemorrhagic Shock in a Rat Model of Penetrating Ballistic-Like Brain Injury. 61
31595817 2020
A Mouse Model for Juvenile, Lateral Fluid Percussion Brain Injury Reveals Sex-Dependent Differences in Neuroinflammation and Functional Recovery. 61
31621484 2020
Music Therapy Enhances Executive Functions and Prefrontal Structural Neuroplasticity after Traumatic Brain Injury: Evidence from a Randomized Controlled Trial. 61
31642408 2020
History of traumatic brain injury interferes with accurate diagnosis of Alzheimer's dementia: a nation-wide case-control study. 61
31707905 2020
A commentary for neuropsychologists on CDC's guideline on the diagnosis and management of mild traumatic brain injury among children. 61
31530221 2020
The reproducibility and responsiveness of subjective assessment of upper limb associated reactions in people with acquired brain injury during walking. 61
31775541 2020
Acute administration of perampanel, an AMPA receptor antagonist, reduces cognitive impairments after traumatic brain injury in rats. 61
32027929 2020
Interferon-β plays a detrimental role in experimental traumatic brain injury by enhancing neuroinflammation that drives chronic neurodegeneration. 61
32029532 2020
Editorial for "Evaluating the Therapeutic Effect of Low-Intensity Transcranial Ultrasound on Traumatic Brain Injury With Diffusion Kurtosis Imaging". 61
32031305 2020
Characterization of Ionic and Lipid Gradients within Corpus Callosum White Matter after Diffuse Traumatic Brain Injury in the Rat. 61
31850738 2020
Multimodal imaging of hair follicle bulge-derived stem cells in a mouse model of traumatic brain injury. 61
32036485 2020
Suppression of NDRG2 alleviates brain injury after intracerebral hemorrhage through mitigating astrocyte-drived glutamate neurotoxicity via NF-κB/GLT1 signaling. 61
31843625 2020
Empathy for people with similar experiences: Can the perception-action model explain empathy impairments after traumatic brain injury? 61
31514609 2020
Therapeutic strategies for ketosis induction and their potential efficacy for the treatment of acute brain injury and neurodegenerative diseases. 61
31785349 2020
A novel mouse model of mild traumatic brain injury using laser-induced shock waves. 61
32036028 2020
IL-13 Ameliorates Neuroinflammation and Promotes Functional Recovery after Traumatic Brain Injury. 61
32034062 2020
Traumatic Brain Injury and Pediatric Acute Respiratory Distress Syndrome: Moving the Field Forward. 61
32032266 2020
A novel rat model of heterotopic ossification after polytrauma with traumatic brain injury. 61
32032779 2020
What characterises work and workplaces that retain their employees following acquired brain injury? Systematic review. 61
31907293 2020
Protective effects of </i>N<i>-oleoylglycine in a mouse model of mild traumatic brain injury. 61
32017529 2020
Experiences of fatigue in daily life of people with acquired brain injury: a qualitative study. 61
32017641 2020

Variations for Brain Injury

Expression for Brain Injury

Search GEO for disease gene expression data for Brain Injury.

Pathways for Brain Injury

GO Terms for Brain Injury

Cellular components related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.03 S100B IL6 IL10 IGF1 EPO ENO2
2 extracellular region GO:0005576 9.96 SPTAN1 S100B MAPT IL6 IL10 IGF1
3 dendrite GO:0030425 9.77 MAPT DRD2 COMT BDNF APOE
4 axon GO:0030424 9.72 UCHL1 MAPT DRD2 COMT BDNF
5 glial cell projection GO:0097386 9.4 MAPT GFAP
6 cell body GO:0044297 9.26 MAPT GFAP EPO COMT
7 neuronal cell body GO:0043025 9.17 UCHL1 S100B MBP MAPT ENO2 CASP3
8 astrocyte end-foot GO:0097450 9.16 GFAP AQP4

Biological processes related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to lipopolysaccharide GO:0032496 9.67 IL10 EPO COMT CASP3
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.61 IL6 IGF1 EPO
3 long-term synaptic potentiation GO:0060291 9.5 SLC24A2 S100B GFAP
4 negative regulation of heterotypic cell-cell adhesion GO:0034115 9.46 MBP IL10
5 axonal transport of mitochondrion GO:0019896 9.4 UCHL1 MAPT
6 regulation of neurotransmitter uptake GO:0051580 9.26 GFAP DRD2
7 response to glucocorticoid GO:0051384 9.26 S100B IL6 IL10 CASP3
8 response to inactivity GO:0014854 9.16 IL10 DRD2
9 memory GO:0007613 9.02 SLC24A2 S100B MAPT BDNF ASIC1

Molecular functions related to Brain Injury according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 UCHL1 SPTAN1 S100B MBP MAPT IL6
2 lipoprotein particle binding GO:0071813 9.16 MAPT APOE
3 growth factor activity GO:0008083 8.92 IL6 IL10 IGF1 BDNF

Sources for Brain Injury

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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