MCID: BRN080
MIFTS: 43

Brain Ischemia

Categories: Neuronal diseases

Aliases & Classifications for Brain Ischemia

MalaCards integrated aliases for Brain Ischemia:

Name: Brain Ischemia 39 56 74

Classifications:



External Ids:

UMLS 74 C0007786

Summaries for Brain Ischemia

MalaCards based summary : Brain Ischemia is related to ischemia and transient cerebral ischemia. An important gene associated with Brain Ischemia is KCNB1 (Potassium Voltage-Gated Channel Subfamily B Member 1), and among its related pathways/superpathways are Circadian entrainment and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). The drugs Aspirin and Probucol have been mentioned in the context of this disorder. Affiliated tissues include Brain and Brain.

Wikipedia : 77 Brain ischemia (a.k.a. cerebral ischemia, cerebrovascular ischemia) is a condition in which there is... more...

Related Diseases for Brain Ischemia

Diseases related to Brain Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 88)
# Related Disease Score Top Affiliating Genes
1 ischemia 30.8 ADORA1 EDN1 GFAP MAP2 NOS2
2 transient cerebral ischemia 11.3
3 anaplastic ganglioglioma 10.3 GFAP NES
4 central nervous system germ cell tumor 10.3 GFAP NES
5 central nervous system primitive neuroectodermal neoplasm 10.3 GFAP NES
6 ependymoblastoma 10.3 GFAP NES
7 astroblastoma 10.3 GFAP NES
8 medulloepithelioma 10.3 GFAP NES
9 subependymoma 10.3 GFAP NES
10 ependymoma 10.3 GFAP NES
11 tanycytic ependymoma 10.3 GFAP NES
12 papillary ependymoma 10.3 GFAP NES
13 gliomatosis cerebri 10.3 GFAP NES
14 subependymal giant cell astrocytoma 10.3 GFAP NES
15 hypoxia 10.2
16 retinitis pigmentosa 42 10.2 GFAP NES
17 brain glioma 10.2 GFAP NES
18 infratentorial cancer 10.2 GFAP NES
19 chiari malformation 10.2 GFAP MAP2
20 neurilemmoma 10.2 GFAP NES
21 hemimegalencephaly 10.2 GFAP MAP2
22 supratentorial cancer 10.2 GFAP NES
23 meningioma, radiation-induced 10.2 GFAP NOS2
24 cerebellar liponeurocytoma 10.2 GFAP MAP2
25 mucopolysaccharidosis, type iiia 10.2 MAP2 NES
26 cerebrum cancer 10.2 GFAP NES
27 diabetic angiopathy 10.1 EDN1 NOS2
28 brain injury 10.1
29 optic nerve neoplasm 10.1 MAP2 NES
30 neuronal migration disorders 10.1 MAP2 NES
31 hepatopulmonary syndrome 10.1 EDN1 NOS2
32 scrapie 10.1 GFAP MAP2
33 hyperglycemia 10.1
34 sleeping sickness 10.1 HSPA8 NOS2
35 spinal cord injury 10.1 GFAP NOS2
36 alzheimer disease 10.0
37 cerebral artery occlusion 10.0
38 nervous system disease 10.0 GFAP NES NOS2
39 toxic encephalopathy 10.0 GFAP MAP2
40 dysembryoplastic neuroepithelial tumor 10.0 GFAP MAP2 NES
41 central neurocytoma 10.0 GFAP MAP2 NES
42 optic nerve glioma 10.0 GFAP MAP2 NES
43 ganglioglioma 10.0 GFAP MAP2 NES
44 central nervous system cancer 10.0 GFAP NES
45 aging 10.0
46 cardiac arrest 10.0
47 depression 10.0
48 impotence 10.0 EDN1 NOS2
49 idiopathic hypercalciuria 9.9 ADCY10 EDN1
50 dementia 9.9

Graphical network of the top 20 diseases related to Brain Ischemia:



Diseases related to Brain Ischemia

Symptoms & Phenotypes for Brain Ischemia

Drugs & Therapeutics for Brain Ischemia

Drugs for Brain Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 492)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
2
Probucol Approved, Investigational Phase 4 23288-49-5 4912
3
Cilostazol Approved, Investigational Phase 4,Phase 3 73963-72-1 2754
4
Levodopa Approved Phase 4 59-92-7 6047
5
Dopamine Approved Phase 4,Phase 2,Phase 3,Not Applicable 62-31-7, 51-61-6 681
6
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 120202-66-6, 113665-84-2 60606
7
Atorvastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 134523-00-5 60823
8
Atenolol Approved Phase 4 29122-68-7 2249
9
Valsartan Approved, Investigational Phase 4,Not Applicable 137862-53-4 60846
10
Angiotensin II Approved, Investigational Phase 4,Phase 2 11128-99-7, 68521-88-0, 4474-91-3 172198
11
Heparin Approved, Investigational Phase 4,Phase 3,Not Applicable 9005-49-6 46507594 772
12
Nadroparin Approved, Investigational Phase 4
13
tannic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable 1401-55-4
14
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
15
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3 7440-66-6 32051
16
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 7487-88-9 24083
17
Edaravone Approved, Investigational Phase 4,Phase 3,Phase 2 89-25-8 70335
18
Dalteparin Approved Phase 4,Phase 3,Phase 2,Not Applicable 9005-49-6
19
Warfarin Approved Phase 4,Phase 2,Phase 3 81-81-2 54678486 6691
20
Rivaroxaban Approved Phase 4,Phase 2,Not Applicable 366789-02-8
21
Apixaban Approved Phase 4,Phase 3,Not Applicable 503612-47-3 10182969
22
Edoxaban Approved Phase 4,Phase 2,Phase 3,Not Applicable 480449-70-5
23
Tocopherol Approved, Investigational Phase 4,Phase 2,Phase 1 1406-66-2 14986
24
Dipyridamole Approved Phase 4,Not Applicable 58-32-2 3108
25
Pseudoephedrine Approved Phase 4,Phase 2,Not Applicable 90-82-4 7028
26
Oxymetazoline Approved, Investigational Phase 4,Phase 2 1491-59-4 4636
27
Ephedrine Approved Phase 4,Phase 2,Not Applicable 299-42-3 9294
28
Phenylephrine Approved Phase 4,Phase 2 59-42-7 6041
29
Nimodipine Approved, Investigational Phase 4,Not Applicable 66085-59-4 4497
30
Triflusal Approved, Investigational Phase 4 322-79-2
31
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 51-43-4 5816
32
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Not Applicable 329-65-7 838
33
Losartan Approved Phase 4 114798-26-4 3961
34
Amlodipine Approved Phase 4,Phase 2,Not Applicable 88150-42-9 2162
35
Histamine Approved, Investigational Phase 4 51-45-6 774
36
Enoxaparin Approved Phase 4,Phase 3 9005-49-6 772
37
Ticlopidine Approved Phase 4 55142-85-3 5472
38
Tranexamic Acid Approved Phase 4 1197-18-8 5526
39
Simvastatin Approved Phase 4,Phase 3,Phase 2,Not Applicable 79902-63-9 54454
40
Pravastatin Approved Phase 4,Phase 3 81093-37-0 54687
41
Iron Approved, Experimental Phase 4,Phase 2,Early Phase 1 7439-89-6, 15438-31-0 27284 23925
42
Allopurinol Approved Phase 4,Phase 3 315-30-0 2094
43
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
44
Abciximab Approved Phase 4,Phase 3 143653-53-6
45
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-70-2 271
46
Serine Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 56-45-1 5951
47
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 59-02-9 14985
48
Vitamin C Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 50-81-7 54670067 5785
49
Choline Approved, Nutraceutical Phase 4,Phase 3 62-49-7 305
50
Dabigatran Investigational Phase 4,Phase 2,Not Applicable 211914-51-1

Interventional clinical trials:

(show top 50) (show all 986)
# Name Status NCT ID Phase Drugs
1 PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study Unknown status NCT02483169 Phase 4 cilostazol;Probucol;Aspirin;placebo of cilostazol;Placebo of aspirin
2 PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage Unknown status NCT01013532 Phase 4 Cilostazol;Probucol;Aspirin;placebo of cilostazol;placebo of aspirin
3 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
4 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
5 The Middle East Dual Anti-platelet Treatment in Acute Transient Ischemic Attack Unknown status NCT02144831 Phase 4 anti-thrombotic treatment using Aspirin (ASA 75-325mg) and Clopidogrel (75mg)
6 The Dynamic Effect of Non-cytochrome P450 Isoenzyme 3A4(CYP3A4)-Metabolized and Cytochrome P450 Isoenzyme 3A4(CYP3A4)-Metabolized Statins on Clopidogrel Resistance in Patients With Cerebral Infarction Unknown status NCT02411903 Phase 4 atorvastatin and clopidogrel;rosuvastatin and clopidogrel
7 The Effect of Erigeron Injection on Acute Cerebral Infarction Serum VEGF, MMP-9 and EPC Levels Unknown status NCT01926834 Phase 4 Erigeron Injection;placebo
8 Effect of Rosuvastatin on Prognosis of Clinical Response in Acute Ischemic Stroke Patients(REPAIRS) Unknown status NCT02484027 Phase 4 Rosuvastatin
9 The Impact of NBP on the Collateral Circulation in ICA/M1 Occlusion Unknown status NCT02594995 Phase 4 NBP
10 Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm Unknown status NCT02581371 Phase 4 Cerebrolysin infusion
11 Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol Unknown status NCT02403349 Phase 4 Fimasartan;Valsartan;Atenolol
12 Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke Unknown status NCT01862978 Phase 4 Heparin;Nadroparin;Placebo
13 Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke Unknown status NCT01758536 Phase 4 Huatuo Zaizao Pills
14 Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy Unknown status NCT01097967 Phase 4
15 Valsartan Efficacy on Modest Blood Pressure Reduction in Acute Ischemic Stroke Unknown status NCT00874601 Phase 4 Diovan® (valsartan)
16 Comparison of Two Strategies for Glycemic Control in Acute Ischemic Stroke Unknown status NCT00747279 Phase 4 Intensive insulin therapy
17 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
18 Single High Dose Vitamin C, E in Severe Birth Asphyxia Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
19 ESPRIT: European/Australasian Stroke Prevention in Reversible Ischaemia Trial Completed NCT00161070 Phase 4 anticoagulation;aspirin and dipyridamole;aspirin alone
20 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
21 Post-marketing Clinical Study of Alteplase for Acute Ischemic Stroke (Japan Alteplase Clinical Trial Ⅱ:J-ACT Ⅱ) Completed NCT00412867 Phase 4 Alteplase
22 The Effect of Cilostazol Compared to Aspirin on Endothelial Function in Acute Cerebral Ischemia Patients Completed NCT03116269 Phase 4 Cilostazol 100mg;Aspirin
23 The Effect of Ventilation on Cerebral Oxygenation in the Sitting Position Completed NCT01546636 Phase 4
24 Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery Completed NCT01794273 Phase 4 ephedrine and phenylephrine
25 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Boostrix™ Vaccine in Pregnant Women Completed NCT02377349 Phase 4 Saline placebo
26 Clopidogrel Response and CYP2C19 Genotype in Ischemic Stroke Patients Completed NCT03385538 Phase 4 Clopidogrel
27 Nimodipine for Treating Acute Massive Cerebral Infarction Completed NCT02248233 Phase 4 Nimodipine;Saline + citicoline
28 Cilostazol Stroke Prevention Study for Antiplatelet Combination Completed NCT01995370 Phase 4 aspirin;clopidogrel;cilostazol
29 Clopidogrel for Acute Ischaemia of Recent Onset Completed NCT02776540 Phase 4 Clopidogrel;Aspirin
30 AdminiStration of Statin On Acute Ischemic stRoke patienT Trial Completed NCT02549846 Phase 4 Statin
31 Curative Efficacy of Secondary Prevention for Patients With Ischemic Stroke Through Syndrome Differentiation of TCM Completed NCT02334969 Phase 4 Naoxintong Capsule;Placebo
32 Atorvastatin in Acute Stroke Treatment Completed NCT02225834 Phase 4 Atorvastatin
33 A Safety Study of Ginkgolides Meglumine Injection in the Treatment of Ischemic Stroke. Completed NCT01958957 Phase 4 Ginkgolides Meglumine Injection
34 Tongxinluo Capsule in Ischemic Stroke Patients(TISS) Completed NCT01919671 Phase 4 Tongxinluo capsule;placebo capsule
35 Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping Completed NCT01174693 Phase 4 Triflusal;Clopidogrel
36 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4 Qizhitongluo Capsule;Naoxintong Capsule;Aspirin Enteric-coated Tablets;placebo
37 Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler Completed NCT00741286 Phase 4 Aspirin;cilostazol
38 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
39 Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke Completed NCT01109836 Phase 4
40 Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO) Completed NCT01088672 Phase 4
41 Overcome Biochemical Aspirin Resistance Through Cilostazol Combination Completed NCT00446641 Phase 4 Cilostazol;placebo
42 Establishment and Evaluation to the Effects of a Clinical Pathway for Acute Ischemic Stroke Completed NCT00966316 Phase 4 aspirin,chinese herbs;
43 Safety and Efficacy of Clopidogrel for Cerebral Infarction Treatment Completed NCT00386191 Phase 4 clopidogrel (SR25990C)
44 Preventing Recurrent Vascular Events in Patients With Stroke or Transient Ischemic Attack Completed NCT00931788 Phase 4 Antihypertensive agents and lipid lowering therapy
45 Study of Continuous Cardiac Monitoring to Assess Atrial Fibrillation After Cryptogenic Stroke Completed NCT00924638 Phase 4
46 AISTCM-Outcome Measurement of Acute Ischemic Stroke With Traditional Chinese Medicine Completed NCT00351806 Phase 4 Erigeron breviscapus injection;hua tuo zai zao wan (a herbal medicine pill);Compound stroke herbal medicine (8 herbal)
47 The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke Completed NCT00868283 Phase 4 Cerebrolysin;0.9% Saline Solution
48 Study of Cilostazol and Probucol Alone and in Combination on Atherosclerosis Related Biomarker---atherosclerosis Cerebral Infarction Patient as Study Subject Completed NCT00823875 Phase 4 Cilostazol group;Probucol group;Cilostazol + Probucol group;control group
49 Cilostazol in Acute Ischemic Stroke Treatment (CAIST) Completed NCT00272454 Phase 4 Cilostazol;Aspirin
50 Platelet Hyperreactivity to Aspirin and Stroke Completed NCT00766896 Phase 4 Aspirin (platelet sensitive versus platelet hyperreactivity)

Search NIH Clinical Center for Brain Ischemia

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Ischemia:
Mesenchymal stem cell-derived neuronal progenitor cells for the treatment of ischemic brain damage
Embryonic/Adult Cultured Cells Related to Brain Ischemia:
Neural progenitor cells PMIDs: 21300404

Genetic Tests for Brain Ischemia

Anatomical Context for Brain Ischemia

MalaCards organs/tissues related to Brain Ischemia:

42
Brain, Bone, Heart, Bone Marrow, Endothelial, Testes, Cortex
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Brain Ischemia:
# Tissue Anatomical CompartmentCell Relevance
1 Brain Forebrain White Matter Fibrous Astrocyte Cells Potential therapeutic candidate
2 Brain Neocortex Protoplasmic Astrocyte Cells Potential therapeutic candidate

Publications for Brain Ischemia

Articles related to Brain Ischemia:

(show top 50) (show all 1092)
# Title Authors Year
1
Understanding aging effects on brain ischemia. ( 31010536 )
2019
2
The role of reactive oxygen species in angiogenesis and preventing tissue injury after brain ischemia. ( 30594490 )
2019
3
Oleoylethanolamide inhibits glial activation via moudulating PPARα and promotes motor function recovery after brain ischemia. ( 30660821 )
2019
4
Effect of intravenous injection of antagomiR-1 on brain ischemia. ( 30707419 )
2019
5
CT perfusion hypervolemia: brain ischemia or stroke mimic? ( 30719544 )
2019
6
A Polyphenol-Enriched Supplement Exerts Potent Epigenetic-Protective Activity in a Cell-Based Model of Brain Ischemia. ( 30736313 )
2019
7
The role of degenerative pathways in the development of irreversible consequences after brain ischemia. ( 30762008 )
2019
8
Neuroprotective effect of grape seed extract on brain ischemia: a proteomic approach. ( 30796716 )
2019
9
Tlr2 Deficiency is Associated with Enhanced Elements of Neuronal Repair and Caspase 3 Activation Following Brain Ischemia. ( 30808918 )
2019
10
Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats. ( 30822224 )
2019
11
Neurotherapeutic potential of kolaviron on neurotransmitter dysregulation, excitotoxicity, mitochondrial electron transport chain dysfunction and redox imbalance in 2-VO brain ischemia/reperfusion injury. ( 30841465 )
2019
12
Combined citicoline and docosahexaenoic acid treatment improves cognitive dysfunction following transient brain ischemia. ( 30871872 )
2019
13
Bioinformatic analysis to explore key genes associated with brain ischemia-reperfusion injury in rats. ( 30889366 )
2019
14
Anti-inflammatory Effects of Traditional Chinese Medicines on Preclinical in vivo Models of Brain Ischemia-Reperfusion-Injury: Prospects for Neuroprotective Drug Discovery and Therapy. ( 30930774 )
2019
15
Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury. ( 30967639 )
2019
16
Photobiomodulation and Coenzyme Q10 Treatments Attenuate Cognitive Impairment Associated With Model of Transient Global Brain Ischemia in Artificially Aged Mice. ( 30983970 )
2019
17
Protective STA-MCA bypass to prevent brain ischemia during high-flow bypass surgery: case series of 10 patients. ( 31004241 )
2019
18
Effect of G-CSF on the Spatial Arrangement of CA1 Hippocampal Pyramidal Neurons after Brain Ischemia in the male Rats. ( 31005633 )
2019
19
Global brain ischemia in rats is associated with mitochondrial release and downregulation of Mfn2 in the cerebral cortex, but not the hippocampus. ( 31017259 )
2019
20
Role of Perivascular Oligodendrocyte Precursor Cells in Angiogenesis After Brain Ischemia. ( 31020902 )
2019
21
Redox-dependent loss of flavin by mitochondrial complex I in brain ischemia/reperfusion injury. ( 31037949 )
2019
22
Protective STA-MCA bypass to prevent brain ischemia during high-flow bypass surgery: case series of 10 patients. ( 31041595 )
2019
23
Global brain ischemia in a dog with concurrent multiorgan dysfunction syndrome after bite wound trauma. ( 31060620 )
2019
24
Early TLR4 blockade reduces ROS and inflammation triggered by microglial pro-inflammatory phenotype in rodents and human brain ischemia models. ( 31074003 )
2019
25
Establishment of Brain Ischemia Model in Tree Shrew. ( 31077648 )
2019
26
Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury. ( 29695462 )
2018
27
Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia. ( 29551690 )
2018
28
SUMOylation in brain ischemia: Patterns, targets, and translational implications. ( 29148315 )
2018
29
Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage. ( 29248829 )
2018
30
G5G2.5 core-shell tecto-dendrimer specifically targets reactive glia in brain ischemia. ( 29280499 )
2018
31
Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia. ( 29315561 )
2018
32
Activation of JAK/STAT3 restores NK-cell function and improves immune defense after brain ischemia. ( 29401578 )
2018
33
Reactive Oxygen Species Play a Biphasic Role in Brain Ischemia. ( 29420085 )
2018
34
The protective effect of alpha-lipoic acid against brain ischemia and reperfusion injury via mTOR signaling pathway in rats. ( 29432779 )
2018
35
A de novo Ser111Thr variant in aquaporin-4 in a patient with intellectual disability, transient signs of brain ischemia, transient cardiac hypertrophy, and progressive gait disturbance. ( 29437797 )
2018
36
Neuroprotective effects of valproic acid on brain ischemia are related to its HDAC and GSK3 inhibitions. ( 29452136 )
2018
37
Inhibitory modulation of cytochrome c oxidase activity with specific near-infrared light wavelengths attenuates brain ischemia/reperfusion injury. ( 29472564 )
2018
38
Role of mTORC1 Controlling Proteostasis after Brain Ischemia. ( 29497356 )
2018
39
Therapeutic Potential of Pretreatment with Allograft Sertoli Cells Transplantation in Brain Ischemia by Improving Oxidative Defenses. ( 29550901 )
2018
40
Flavonoids and its Neuroprotective Effects on Brain Ischemia and Neurodegenerative Diseases. ( 29577854 )
2018
41
Critical Role of Flavin and Glutathione in Complex I-Mediated Bioenergetic Failure in Brain Ischemia/Reperfusion Injury. ( 29643256 )
2018
42
Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia. ( 29689717 )
2018
43
Publisher Correction: Inhibitory modulation of cytochrome c oxidase activity with specific near-infrared light wavelengths attenuates brain ischemia/reperfusion injury. ( 29695825 )
2018
44
Bioinformatics analysis of microarray data to reveal the pathogenesis of brain ischemia. ( 29749511 )
2018
45
Enhancement of bradykinin-induced relaxation by focal brain ischemia in the rat middle cerebral artery: Receptor expression upregulation and activation of multiple pathways. ( 29912902 )
2018
46
Multidetector CT angiography of the Circle of Willis: association of its variants with carotid artery disease and brain ischemia. ( 29922933 )
2018
47
HMG-CoA Reductase Inhibitors Relieve Endoplasmic Reticulum Stress by Autophagy Inhibition in Rats With Permanent Brain Ischemia. ( 29970982 )
2018
48
Quantitative imaging mass spectroscopy reveals roles of heme oxygenase-2 for protecting against transhemispheric diaschisis in the brain ischemia. ( 30087547 )
2018
49
The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: In vivo assessment and a randomized controlled trial. ( 30098076 )
2018
50
Changes of Doublecortin-Immunoreactive Cells from the Acute Phase to Chronic Phase After Transient Global Brain Ischemia in Rat Cingulate Cortex. ( 30178326 )
2018

Variations for Brain Ischemia

Expression for Brain Ischemia

Search GEO for disease gene expression data for Brain Ischemia.

Pathways for Brain Ischemia

GO Terms for Brain Ischemia

Cellular components related to Brain Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 9.32 GFAP NES
2 terminal bouton GO:0043195 9.26 ADORA1 HSPA8
3 basal part of cell GO:0045178 9.16 ADCY10 EDN1
4 cell body GO:0044297 9.13 ADORA1 GFAP MAP2
5 dendrite GO:0030425 9.02 ADCY10 ADORA1 HSPA8 KCNB1 MAP2

Biological processes related to Brain Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron death GO:1901216 9.43 ADORA1 PARP1
2 response to hypoxia GO:0001666 9.43 ADORA1 EDN1 NOS2
3 regulation of sensory perception of pain GO:0051930 9.4 ADORA1 EDN1
4 negative regulation of blood pressure GO:0045776 9.37 ADORA1 NOS2
5 positive regulation of cardiac muscle hypertrophy GO:0010613 9.32 EDN1 PARP1
6 regulation of cellular protein localization GO:1903827 9.16 MAP2 PARP1
7 regulation of protein complex assembly GO:0043254 8.96 GFAP HSPA8
8 negative regulation of hormone secretion GO:0046888 8.62 ADORA1 EDN1

Molecular functions related to Brain Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.8 GFAP MAP2 NES

Sources for Brain Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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