MCID: BRN080
MIFTS: 41

Brain Ischemia

Categories: Neuronal diseases

Aliases & Classifications for Brain Ischemia

MalaCards integrated aliases for Brain Ischemia:

Name: Brain Ischemia 38 55 73

Classifications:



External Ids:

UMLS 73 C0007786

Summaries for Brain Ischemia

MalaCards based summary : Brain Ischemia is related to ischemia and transient cerebral ischemia. An important gene associated with Brain Ischemia is KCNB1 (Potassium Voltage-Gated Channel Subfamily B Member 1), and among its related pathways/superpathways are Circadian entrainment and Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF). The drugs Aspirin and Probucol have been mentioned in the context of this disorder. Affiliated tissues include Brain and Brain.

Wikipedia : 76 Brain ischemia (a.k.a. cerebral ischemia, cerebrovascular ischemia) is a condition in which there is... more...

Related Diseases for Brain Ischemia

Diseases related to Brain Ischemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 82)
# Related Disease Score Top Affiliating Genes
1 ischemia 31.1 ADORA1 EDN1 GFAP MAP2 NOS2
2 transient cerebral ischemia 11.3
3 hypoxia 10.2
4 anaplastic ganglioglioma 10.2 GFAP NES
5 central nervous system germ cell tumor 10.2 GFAP NES
6 central nervous system primitive neuroectodermal neoplasm 10.2 GFAP NES
7 ependymoblastoma 10.2 GFAP NES
8 astroblastoma 10.2 GFAP NES
9 medulloepithelioma 10.2 GFAP NES
10 subependymoma 10.2 GFAP NES
11 ependymoma 10.2 GFAP NES
12 tanycytic ependymoma 10.2 GFAP NES
13 papillary ependymoma 10.2 GFAP NES
14 gliomatosis cerebri 10.2 GFAP NES
15 subependymal giant cell astrocytoma 10.2 GFAP NES
16 retinitis pigmentosa 42 10.1 GFAP NES
17 brain glioma 10.1 GFAP NES
18 chiari malformation 10.1 GFAP MAP2
19 brain injury 10.1
20 neurilemmoma 10.1 GFAP NES
21 hemimegalencephaly 10.1 GFAP MAP2
22 mucopolysaccharidosis, type iiia 10.1 MAP2 NES
23 cerebellar liponeurocytoma 10.1 GFAP MAP2
24 meningioma, radiation-induced 10.1 GFAP NOS2
25 supratentorial cancer 10.1 GFAP NES
26 diabetic angiopathy 10.1 EDN1 NOS2
27 optic nerve neoplasm 10.1 MAP2 NES
28 cerebrum cancer 10.1 GFAP NES
29 neuronal migration disorders 10.1 MAP2 NES
30 hyperglycemia 10.1
31 sleeping sickness 10.1 HSPA8 NOS2
32 hepatopulmonary syndrome 10.1 EDN1 NOS2
33 scrapie 10.1 GFAP MAP2
34 alzheimer disease 10.0
35 cerebral artery occlusion 10.0
36 spinal cord injury 10.0 GFAP NOS2
37 nervous system disease 10.0 GFAP NES NOS2
38 dysembryoplastic neuroepithelial tumor 10.0 GFAP MAP2 NES
39 central neurocytoma 10.0 GFAP MAP2 NES
40 optic nerve glioma 10.0 GFAP MAP2 NES
41 ganglioglioma 10.0 GFAP MAP2 NES
42 cardiac arrest 10.0
43 toxic encephalopathy 10.0 GFAP MAP2
44 depression 9.9
45 idiopathic hypercalciuria 9.9 ADCY10 EDN1
46 impotence 9.9 EDN1 NOS2
47 central nervous system cancer 9.9 GFAP NES
48 aging 9.9
49 dementia 9.9
50 vascular dementia 9.9

Graphical network of the top 20 diseases related to Brain Ischemia:



Diseases related to Brain Ischemia

Symptoms & Phenotypes for Brain Ischemia

Drugs & Therapeutics for Brain Ischemia

Drugs for Brain Ischemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 477)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 50-78-2 2244
2
Probucol Approved, Investigational Phase 4 23288-49-5 4912
3
Cilostazol Approved, Investigational Phase 4,Phase 3 73963-72-1 2754
4
Levodopa Approved Phase 4 59-92-7 6047
5
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-61-6, 62-31-7 681
6
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 113665-84-2, 120202-66-6 60606
7
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1,Not Applicable 55142-85-3 5472
8
Atenolol Approved Phase 4 29122-68-7 2249
9
Valsartan Approved, Investigational Phase 4,Not Applicable 137862-53-4 60846
10
Angiotensin II Approved, Investigational Phase 4,Phase 2 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
11
Heparin Approved, Investigational Phase 4,Phase 3 9005-49-6 772 46507594
12
Nadroparin Approved, Investigational Phase 4
13 tannic acid Approved Phase 4,Phase 3,Phase 2,Not Applicable
14
Benzocaine Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 94-09-7, 1994-09-7 2337
15
Zinc Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 7440-66-6
16
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 7487-88-9 24083
17
Dalteparin Approved Phase 4,Phase 3,Phase 2 9005-49-6
18
Warfarin Approved Phase 4,Phase 2,Phase 3 81-81-2 6691 54678486
19 Edoxaban Approved Phase 4,Phase 2,Phase 3,Not Applicable 480449-70-5
20
Rivaroxaban Approved Phase 4,Phase 2,Not Applicable 366789-02-8
21
Apixaban Approved Phase 4,Phase 3,Not Applicable 503612-47-3 10182969
22 Piracetam Approved, Investigational Phase 4,Phase 2 7491-74-9
23
Tocopherol Approved, Investigational Phase 4,Phase 2,Phase 1 1406-66-2 14986
24
Dipyridamole Approved Phase 4,Not Applicable 58-32-2 3108
25
Pseudoephedrine Approved Phase 4,Phase 2,Not Applicable 90-82-4 7028
26
Oxymetazoline Approved, Investigational Phase 4,Phase 2 1491-59-4 4636
27
Ephedrine Approved Phase 4,Phase 2,Not Applicable 299-42-3 9294
28
Phenylephrine Approved Phase 4,Phase 2 59-42-7 6041
29
Nimodipine Approved, Investigational Phase 4,Not Applicable 66085-59-4 4497
30
Triflusal Approved, Investigational Phase 4 322-79-2
31
Racepinephrine Approved Phase 4,Phase 2,Phase 3,Not Applicable 329-65-7 838
32
Epinephrine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Not Applicable 51-43-4 5816
33
Losartan Approved Phase 4 114798-26-4 3961
34
Amlodipine Approved Phase 4,Phase 2,Not Applicable 88150-42-9 2162
35
Antipyrine Approved, Investigational Phase 4,Phase 3,Phase 2 60-80-0 2206
36
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
37
Enoxaparin Approved Phase 4,Phase 3 9005-49-6 772
38
Tranexamic Acid Approved Phase 4 1197-18-8 5526
39
Pravastatin Approved Phase 4,Phase 3 81093-37-0 54687
40
Simvastatin Approved Phase 4,Phase 3,Phase 2,Not Applicable 79902-63-9 54454
41
Iron Approved Phase 4,Phase 2,Early Phase 1 7439-89-6 23925
42
Allopurinol Approved Phase 4,Phase 3 315-30-0 2094
43
Fluvastatin Approved Phase 4 93957-54-1 1548972
44
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
45
Abciximab Approved Phase 4,Phase 3 143653-53-6
46
Serine Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Not Applicable 56-45-1 5951
47
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 1 59-02-9 14985
48
Vitamin C Approved, Nutraceutical Phase 4,Phase 2,Not Applicable 50-81-7 5785 54670067
49
Choline Approved, Nutraceutical Phase 4,Phase 3 62-49-7 305
50 Tocotrienol Investigational Phase 4,Phase 2,Phase 1 6829-55-6

Interventional clinical trials:

(show top 50) (show all 961)
# Name Status NCT ID Phase Drugs
1 PreventIon of IMT Progression in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage-IMT Study Unknown status NCT02483169 Phase 4 cilostazol;Probucol;Aspirin;placebo of cilostazol;Placebo of aspirin
2 PreventIon of CArdiovascular Events in iSchemic Stroke Patients With High Risk of Cerebral HemOrrhage Unknown status NCT01013532 Phase 4 Cilostazol;Probucol;Aspirin;placebo of cilostazol;placebo of aspirin
3 Delayed Vasospasm After Aneurysm With the Standardization Treatment of Traditional Chinese Medicine Unknown status NCT01840761 Phase 4 herbal drug;placebo
4 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
5 The Middle East Dual Anti-platelet Treatment in Acute Transient Ischemic Attack Unknown status NCT02144831 Phase 4 anti-thrombotic treatment using Aspirin (ASA 75-325mg) and Clopidogrel (75mg)
6 The Dynamic Effect of Non-cytochrome P450 Isoenzyme 3A4(CYP3A4)-Metabolized and Cytochrome P450 Isoenzyme 3A4(CYP3A4)-Metabolized Statins on Clopidogrel Resistance in Patients With Cerebral Infarction Unknown status NCT02411903 Phase 4 atorvastatin and clopidogrel;rosuvastatin and clopidogrel
7 The Effect of Erigeron Injection on Acute Cerebral Infarction Serum VEGF, MMP-9 and EPC Levels Unknown status NCT01926834 Phase 4 Erigeron Injection;placebo
8 Effect of Rosuvastatin on Prognosis of Clinical Response in Acute Ischemic Stroke Patients(REPAIRS) Unknown status NCT02484027 Phase 4 Rosuvastatin
9 The Impact of NBP on the Collateral Circulation in ICA/M1 Occlusion Unknown status NCT02594995 Phase 4 NBP
10 Comprehensive Reparative Therapy in Ischemic Stroke COMplex Repair in Ischemic Stroke-Arm Unknown status NCT02581371 Phase 4 Cerebrolysin infusion
11 Comparison of Peripheral and Cerebral Arterial Flow in Acute Ischemic Stroke: Fimasartan vs. Valsartan vs. Atenolol Unknown status NCT02403349 Phase 4 Fimasartan;Valsartan;Atenolol
12 Safety and Efficacy of Heparin and Nadroparin in the Acute Phase of Ischemic Stroke Unknown status NCT01862978 Phase 4 Heparin;Nadroparin;Placebo
13 Efficacy Study of Huatuo Zaizao Pills in Improving of Neural Function in Acute Ischemic Stroke Unknown status NCT01758536 Phase 4 Huatuo Zaizao Pills
14 Sleep Disordered Breathing in Transient Ischemic Attack (TIA)/Ischemic Stroke and Continuous Positive Airway Pressure (CPAP) Treatment Efficacy Unknown status NCT01097967 Phase 4
15 Valsartan Efficacy on Modest Blood Pressure Reduction in Acute Ischemic Stroke Unknown status NCT00874601 Phase 4 Diovan® (valsartan)
16 Comparison of Two Strategies for Glycemic Control in Acute Ischemic Stroke Unknown status NCT00747279 Phase 4 Intensive insulin therapy
17 The Effectiveness and Safety of Butylphthalide Soft Capsules in Secondary Prevention of Ischemic Stroke Trial Unknown status NCT00724724 Phase 4 Butylphthalide Soft Capsules;Aspirin
18 Single High Dose Vitamin C, E in Severe Birth Asphyxia Completed NCT01743742 Phase 4 Vitamin E, Vitamin C
19 ESPRIT: European/Australasian Stroke Prevention in Reversible Ischaemia Trial Completed NCT00161070 Phase 4 anticoagulation;aspirin and dipyridamole;aspirin alone
20 Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth Completed NCT00120588 Phase 4 magnesium
21 Post-marketing Clinical Study of Alteplase for Acute Ischemic Stroke (Japan Alteplase Clinical Trial Ⅱ:J-ACT Ⅱ) Completed NCT00412867 Phase 4 Alteplase
22 The Effect of Cilostazol Compared to Aspirin on Endothelial Function in Acute Cerebral Ischemia Patients Completed NCT03116269 Phase 4 Cilostazol 100mg;Aspirin
23 The Effect of Ventilation on Cerebral Oxygenation in the Sitting Position Completed NCT01546636 Phase 4
24 Compared Efficacy and Tolerance of Two Vasopressors Used to Treat Preoperative Hypotension During Carotid Surgery Completed NCT01794273 Phase 4 ephedrine and phenylephrine
25 Clopidogrel Response and CYP2C19 Genotype in Ischemic Stroke Patients Completed NCT03385538 Phase 4 Clopidogrel
26 Nimodipine for Treating Acute Massive Cerebral Infarction Completed NCT02248233 Phase 4 Nimodipine;Saline + citicoline
27 AdminiStration of Statin On Acute Ischemic stRoke patienT Trial Completed NCT02549846 Phase 4 Statin
28 Curative Efficacy of Secondary Prevention for Patients With Ischemic Stroke Through Syndrome Differentiation of TCM Completed NCT02334969 Phase 4 Naoxintong Capsule;Placebo
29 Atorvastatin in Acute Stroke Treatment Completed NCT02225834 Phase 4 Atorvastatin
30 A Safety Study of Ginkgolides Meglumine Injection in the Treatment of Ischemic Stroke. Completed NCT01958957 Phase 4 Ginkgolides Meglumine Injection
31 Tongxinluo Capsule in Ischemic Stroke Patients(TISS) Completed NCT01919671 Phase 4 Tongxinluo capsule;placebo capsule
32 Comparison of Triflusal and Clopidogrel in Secondary Prevention of Stroke Based on the Genotyping Completed NCT01174693 Phase 4 Triflusal;Clopidogrel
33 Efficacy and Safety of Qizhitongluo Capsule in the Recovery Phase of Ischemic Stroke Completed NCT01762163 Phase 4 Qizhitongluo Capsule;Naoxintong Capsule;Aspirin Enteric-coated Tablets;placebo
34 Effect of Cilostazol in the Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler Completed NCT00741286 Phase 4 Aspirin;cilostazol
35 The Safety and Efficacy of Cilostazol in Ischemic Stroke Patients With Peripheral Arterial Disease (SPAD Study) Completed NCT01188824 Phase 4 Cilostazol
36 Austrian Polyintervention Study to Prevent Cognitive Decline After Ischemic Stroke Completed NCT01109836 Phase 4
37 Thrombectomy REvascularization of Large Vessel Occlusions in Acute Ischemic Stroke (TREVO) Completed NCT01088672 Phase 4
38 Overcome Biochemical Aspirin Resistance Through Cilostazol Combination Completed NCT00446641 Phase 4 Cilostazol;placebo
39 Establishment and Evaluation to the Effects of a Clinical Pathway for Acute Ischemic Stroke Completed NCT00966316 Phase 4 aspirin,chinese herbs;
40 Safety and Efficacy of Clopidogrel for Cerebral Infarction Treatment Completed NCT00386191 Phase 4 clopidogrel (SR25990C)
41 Preventing Recurrent Vascular Events in Patients With Stroke or Transient Ischemic Attack Completed NCT00931788 Phase 4 Antihypertensive agents and lipid lowering therapy
42 Study of Continuous Cardiac Monitoring to Assess Atrial Fibrillation After Cryptogenic Stroke Completed NCT00924638 Phase 4
43 AISTCM-Outcome Measurement of Acute Ischemic Stroke With Traditional Chinese Medicine Completed NCT00351806 Phase 4 Erigeron breviscapus injection;hua tuo zai zao wan (a herbal medicine pill);Compound stroke herbal medicine (8 herbal)
44 The Safety and Efficacy of Cerebrolysin in Patients With Acute Ischemic Stroke Completed NCT00868283 Phase 4 Cerebrolysin;0.9% Saline Solution
45 Study of Cilostazol and Probucol Alone and in Combination on Atherosclerosis Related Biomarker---atherosclerosis Cerebral Infarction Patient as Study Subject Completed NCT00823875 Phase 4 Cilostazol group;Probucol group;Cilostazol + Probucol group;control group
46 Cilostazol in Acute Ischemic Stroke Treatment (CAIST) Completed NCT00272454 Phase 4 Cilostazol;Aspirin
47 Platelet Hyperreactivity to Aspirin and Stroke Completed NCT00766896 Phase 4 Aspirin (platelet sensitive versus platelet hyperreactivity)
48 The Effect of Losartan Versus Amlodipine-based Therapy in Ischemic Stroke (0954-338)(COMPLETED) Completed NCT00754429 Phase 4 losartan;amlodipine
49 Post-marketing Study of Cilostazol (Cilostazol Stroke Prevention Study 2) Completed NCT00234065 Phase 4 Cilostazol;Aspirin
50 Edaravone-Sodium Ozagrel Comparative Post-Marketing Study on Acute Ischemic Stroke Completed NCT00200356 Phase 4 Edaravone;Sodium Ozagrel

Search NIH Clinical Center for Brain Ischemia

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Brain Ischemia cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Brain Ischemia:
Mesenchymal stem cell-derived neuronal progenitor cells for the treatment of ischemic brain damage
Embryonic/Adult Cultured Cells Related to Brain Ischemia:
Neural progenitor cells PMIDs: 21300404

Genetic Tests for Brain Ischemia

Anatomical Context for Brain Ischemia

MalaCards organs/tissues related to Brain Ischemia:

41
Brain, Heart, Cortex, Endothelial, Bone, Monocytes, Spinal Cord
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Brain Ischemia:
# Tissue Anatomical CompartmentCell Relevance
1 Brain Forebrain White Matter Fibrous Astrocyte Cells Potential therapeutic candidate
2 Brain Neocortex Protoplasmic Astrocyte Cells Potential therapeutic candidate

Publications for Brain Ischemia

Articles related to Brain Ischemia:

(show top 50) (show all 1009)
# Title Authors Year
1
Mechanism of Tau Hyperphosphorylation Involving Lysosomal Enzyme Asparagine Endopeptidase in a Mouse Model of Brain Ischemia. ( 29689717 )
2018
2
Neuroprotective effects of valproic acid on brain ischemia are related to its HDAC and GSK3 inhibitions. ( 29452136 )
2018
3
Critical Role of Flavin and Glutathione in Complex I-Mediated Bioenergetic Failure in Brain Ischemia/Reperfusion Injury. ( 29643256 )
2018
4
The protective effect of alpha-lipoic acid against brain ischemia and reperfusion injury via mTOR signaling pathway in rats. ( 29432779 )
2018
5
Acute and long-term NCX activation reduces brain injury and restores behavioral functions in mice subjected to neonatal brain ischemia. ( 29551690 )
2018
6
Multidetector CT angiography of the Circle of Willis: association of its variants with carotid artery disease and brain ischemia. ( 29922933 )
2018
7
HMG-CoA Reductase Inhibitors Relieve Endoplasmic Reticulum Stress by Autophagy Inhibition in Rats With Permanent Brain Ischemia. ( 29970982 )
2018
8
Role of mTORC1 Controlling Proteostasis after Brain Ischemia. ( 29497356 )
2018
9
Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury. ( 29695462 )
2018
10
SUMOylation in brain ischemia: Patterns, targets, and translational implications. ( 29148315 )
2018
11
Reactive Oxygen Species Play a Biphasic Role in Brain Ischemia. ( 29420085 )
2018
12
Publisher Correction: Inhibitory modulation of cytochrome c oxidase activity with specific near-infrared light wavelengths attenuates brain ischemia/reperfusion injury. ( 29695825 )
2018
13
Activation of JAK/STAT3 restores NK-cell function and improves immune defense after brain ischemia. ( 29401578 )
2018
14
Faim2 contributes to neuroprotection by erythropoietin in transient brain ischemia. ( 29315561 )
2018
15
Therapeutic Potential of Pretreatment with Allograft Sertoli Cells Transplantation in Brain Ischemia by Improving Oxidative Defenses. ( 29550901 )
2018
16
Bioinformatics analysis of microarray data to reveal the pathogenesis of brain ischemia. ( 29749511 )
2018
17
A de novo Ser111Thr variant in aquaporin-4 in a patient with intellectual disability, transient signs of brain ischemia, transient cardiac hypertrophy, and progressive gait disturbance. ( 29437797 )
2018
18
Flavonoids and its neuroprotective effects on brain ischemia and neurodegenerative diseases. ( 29577854 )
2018
19
Enhancement of bradykinin-induced relaxation by focal brain ischemia in the rat middle cerebral artery: Receptor expression upregulation and activation of multiple pathways. ( 29912902 )
2018
20
Inhibitory modulation of cytochrome c oxidase activity with specific near-infrared light wavelengths attenuates brain ischemia/reperfusion injury. ( 29472564 )
2018
21
Quantitative imaging mass spectroscopy reveals roles of heme oxygenase-2 for protecting against transhemispheric diaschisis in the brain ischemia. ( 30087547 )
2018
22
The protective effect of melatonin on brain ischemia and reperfusion in rats and humans: In vivo assessment and a randomized controlled trial. ( 30098076 )
2018
23
Changes of Doublecortin-Immunoreactive Cells from the Acute Phase to Chronic Phase After Transient Global Brain Ischemia in Rat Cingulate Cortex. ( 30178326 )
2018
24
Contributions of the Hippocampal CA3 Circuitry to Acute Seizures and Hyperexcitability Responses in Mouse Models of Brain Ischemia. ( 30210302 )
2018
25
Tau Protein Dysfunction after Brain Ischemia. ( 30282370 )
2018
26
Intranasal delivery of a Fas-blocking peptide attenuates Fas-mediated apoptosis in brain ischemia. ( 30301943 )
2018
27
Ischemic postconditioning confers cerebroprotection by stabilizing VDACs after brain ischemia. ( 30305621 )
2018
28
PAMAM dendrimers: blood-brain barrier transport and neuronal uptake after focal brain ischemia. ( 30308255 )
2018
29
Histone Hyperacetylation as a Response to Global Brain Ischemia Associated with Hyperhomocysteinemia in Rats. ( 30322095 )
2018
30
Cofilin-actin rod formation in neuronal processes after brain ischemia. ( 30325927 )
2018
31
Sevoflurane preconditioning induces tolerance to brain ischemia partially via inhibiting thioredoxin-1 nitration. ( 30447684 )
2018
32
Preconditioning exercise reduces brain damage and neuronal apoptosis through enhanced endogenous 14-3-3γ after focal brain ischemia in rats. ( 30478609 )
2018
33
Neuroprotective and Neurological/Cognitive Enhancement Effects of Curcumin after Brain Ischemia Injury with Alzheimer's Disease Phenotype. ( 30545070 )
2018
34
Glutamate dehydrogenase as a neuroprotective target against brain ischemia and reperfusion. ( 27845178 )
2017
35
Semi-synthetic sapogenin exerts neuroprotective effects by skewing the brain ischemia reperfusion transcriptome towards inflammatory resolution. ( 28390980 )
2017
36
Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage. ( 29248829 )
2017
37
Corrigendum to "NCX1 and NCX3: Two new effectors of delayed preconditioning in brain ischemia" [Neurobiol. Dis. 45 (2012) 616-623]. ( 27939918 )
2017
38
Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia. ( 28843543 )
2017
39
LOTUS overexpression accelerates neuronal plasticity after focal brain ischemia in mice. ( 28880879 )
2017
40
Early Reperfusion After Brain Ischemia Has Beneficial Effects Beyond Rescuing Neurons. ( 28626056 )
2017
41
Curcumin reverses neurochemical, histological and immuno-histochemical alterations in the model of global brain ischemia. ( 28053883 )
2017
42
Combined l-citrulline and glutathione administration prevents neuronal cell death following transient brain ischemia. ( 28315310 )
2017
43
Shifting Perceptions of Risk and Reward: Use of Anticoagulation in Patients With Acute Brain Ischemia and Atrial Fibrillation: Nine-Year Data From a National Acute Stroke Registry (National Acute Stroke Israeli Survey [NASIS]). ( 28258255 )
2017
44
Nontraditional Lipid Variables Predict Recurrent Brain Ischemia in Embolic Stroke of Undetermined Source. ( 28412318 )
2017
45
A new threshold of apparent diffusion coefficient values in white matter after successful tissue plasminogen activator treatment for acute brain ischemia. ( 28187865 )
2017
46
Sigma-1 receptor in brain ischemia/reperfusion: Possible role in the NR2A-induced pathway to regulate brain-derived neurotrophic factor. ( 28431607 )
2017
47
Transplantation of feeder-free human induced pluripotent stem cell-derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia. ( 29110329 )
2017
48
Brain ischemia: CT and MRI techniques in acute ischemic stroke. ( 29054448 )
2017
49
The effects of Y-27632 on pial microvessels during global brain ischemia and reperfusion in rabbits. ( 28270098 )
2017
50
Reverse electron transfer results in a loss of flavin from mitochondrial complex I: Potential mechanism for brain ischemia reperfusion injury. ( 28914132 )
2017

Variations for Brain Ischemia

Expression for Brain Ischemia

Search GEO for disease gene expression data for Brain Ischemia.

Pathways for Brain Ischemia

GO Terms for Brain Ischemia

Cellular components related to Brain Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 9.32 GFAP NES
2 terminal bouton GO:0043195 9.26 ADORA1 HSPA8
3 basal part of cell GO:0045178 9.16 ADCY10 EDN1
4 cell body GO:0044297 9.13 ADORA1 GFAP MAP2
5 dendrite GO:0030425 9.02 ADCY10 ADORA1 HSPA8 KCNB1 MAP2

Biological processes related to Brain Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of neuron death GO:1901216 9.43 ADORA1 PARP1
2 response to hypoxia GO:0001666 9.43 ADORA1 EDN1 NOS2
3 regulation of sensory perception of pain GO:0051930 9.4 ADORA1 EDN1
4 negative regulation of blood pressure GO:0045776 9.37 ADORA1 NOS2
5 positive regulation of cardiac muscle hypertrophy GO:0010613 9.32 EDN1 PARP1
6 regulation of cellular protein localization GO:1903827 9.16 MAP2 PARP1
7 regulation of protein complex assembly GO:0043254 8.96 GFAP HSPA8
8 negative regulation of hormone secretion GO:0046888 8.62 ADORA1 EDN1

Molecular functions related to Brain Ischemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.8 GFAP MAP2 NES

Sources for Brain Ischemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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