MCID: BRN034
MIFTS: 22

Brain Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Meningioma

MalaCards integrated aliases for Brain Meningioma:

Name: Brain Meningioma 38 12 15
Intracranial Meningioma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060106

Summaries for Brain Meningioma

MalaCards based summary : Brain Meningioma, also known as intracranial meningioma, is related to childhood brain meningioma and calvarial hyperostosis, and has symptoms including headache and seizures. An important gene associated with Brain Meningioma is CASP9 (Caspase 9). The drugs Bevacizumab and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include Brain, brain and bone.

Related Diseases for Brain Meningioma

Diseases related to Brain Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 childhood brain meningioma 12.0
2 calvarial hyperostosis 9.6
3 hyperostosis 9.6
4 cervicitis 9.6
5 radiculopathy 9.6
6 back pain 9.6
7 medulloblastoma 9.2 CASP9 GFAP
8 alzheimer disease 9.0 CASP9 GFAP

Graphical network of the top 20 diseases related to Brain Meningioma:



Diseases related to Brain Meningioma

Symptoms & Phenotypes for Brain Meningioma

UMLS symptoms related to Brain Meningioma:


headache, seizures

Drugs & Therapeutics for Brain Meningioma

Drugs for Brain Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
4
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
5
Somatostatin Approved, Investigational Phase 2 38916-34-6, 51110-01-1 53481605
6 Hormone Antagonists Phase 2
7 Hormones Phase 2
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
9 Angiogenesis Inhibitors Phase 2
10 Angiogenesis Modulating Agents Phase 2
11 Anti-Bacterial Agents Phase 2
12 Antibiotics, Antitubercular Phase 2
13 Antifungal Agents Phase 2
14 Anti-Infective Agents Phase 2
15 Immunosuppressive Agents Phase 2
16 Antibodies Phase 1
17 Antibodies, Monoclonal Phase 1
18
Cobalt Phase 1 7440-48-4 104729
19 Immunoglobulins Phase 1
20
Dalteparin Approved 9005-49-6
21
Enoxaparin Approved 9005-49-6 772
22
Heparin Approved, Investigational 9005-49-6 772 46507594
23 calcium heparin
24 Heparin, Low-Molecular-Weight

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Radiotherapy or Radiosurgery Compared With Observation Alone in Treating Patients With Newly Diagnosed, Benign Meningioma That Has Been Partially Removed by Surgery Terminated NCT00104936 Phase 3
2 Monthly SOM230C for Recurrent or Progressive Meningioma Completed NCT00859040 Phase 2 SOM230C
3 Vismodegib and FAK Inhibitor GSK2256098 in Treating Patients With Progressive Meningiomas Suspended NCT02523014 Phase 2 vismodegib;GSK2256098
4 Trial of the Combination of Bevacizumab and Everolimus in Patients With Refractory, Progressive Intracranial Meningioma Terminated NCT00972335 Phase 2 Everolimus;Bevacizumab
5 Phase II Study of SOM230 in Patients With Recurrent or Progressive Meningioma Terminated NCT00813592 Phase 2 SOM230B
6 Hyperbaric Oxygen Therapy Can Improve Neurological State Post Meningioma Removal Surgery Unknown status NCT02084927 Phase 1
7 Neoadjuvant Avelumab and Hypofractionated Proton Radiation Therapy Followed by Surgery for Recurrent Radiation-refractory Meningioma Recruiting NCT03267836 Phase 1 Avelumab
8 A Comparative Study of Prophylactic Anticoagulation in Meningioma Surgery Completed NCT01941602 prophylactic enoxaparin
9 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
10 Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery Recruiting NCT03180268 Not Applicable
11 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127

Search NIH Clinical Center for Brain Meningioma

Genetic Tests for Brain Meningioma

Anatomical Context for Brain Meningioma

MalaCards organs/tissues related to Brain Meningioma:

41
Brain, Bone
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Brain Meningioma:
# Tissue Anatomical CompartmentCell Relevance
1 Brain Anterior Dura Mater Affected by disease

Publications for Brain Meningioma

Articles related to Brain Meningioma:

# Title Authors Year
1
Carotid artery stenting in patients with brain meningioma. ( 24791910 )
2014
2
Rare giant bilateral calvarial hyperostosis across the superior sagittal sinus secondary to brain meningioma: A case report. ( 24959261 )
2014
3
Brain meningioma with initial manifestation similar to cervical radiculopathy: a case report. ( 25028552 )
2014
4
Surgical Resection of Twenty-Three Cases of Brain Meningioma. ( 24200893 )
2013
5
Brain meningioma in a patient with complaints of low back pain and leg weakness. ( 23126500 )
2013
6
Brain meningioma invading and destructing the skull bone: replacement of the missing bone in vivo. ( 22933971 )
2011
7
Microscopic anatomy of the brain-meningioma interface. ( 18095106 )
2005
8
The occurrence of polyunsaturated aldehydes in choline-containing phosphoglycerides of a human brain meningioma. ( 6064623 )
1967

Variations for Brain Meningioma

Expression for Brain Meningioma

Search GEO for disease gene expression data for Brain Meningioma.

Pathways for Brain Meningioma

GO Terms for Brain Meningioma

Sources for Brain Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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