Brain Meningioma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Sources

Aliases & Classifications for Brain Meningioma

MalaCards integrated aliases for Brain Meningioma:

Name: Brain Meningioma ¹¹ ¹⁴

Intracranial Meningioma ⁷¹

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0060106

UMLS ⁷¹ C0349604

Sources

Summaries for Brain Meningioma

Disease Ontology: ¹¹ A brain cancer that is characterized by tumor of the meninges, that develops from the membranes that surround the brain and spinal cord, has material basis in abnormally proliferating cells derives from meningeal cells of embryonic ectoderm origin.

MalaCards based summary: Brain Meningioma, also known as intracranial meningioma, is related to benign meningioma and intracranial meningioma, and has symptoms including headache and seizures. An important gene associated with Brain Meningioma is NF2 (NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor), and among its related pathways/superpathways are RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known and Tumor suppressor activity of SMARCB1. The drugs Everolimus and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include Brain, spinal cord and temporal lobe, and related phenotype is Increased proliferation.

Sources

Related Diseases for Brain Meningioma

Diseases related to Brain Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)

#	Related Disease	Score	Top Affiliating Genes
1	benign meningioma	30.1	TRAF7 PGR NF2
2	intracranial meningioma	28.4	TRAF7 SSTR2 SST SMARCE1 SMARCB1 PGR
3	meningioma, familial	28.2	TRAF7 SSTR2 SST SMO SMARCE1 SMARCB1
4	childhood brain meningioma	11.4
5	foramen magnum meningioma	10.3	TRAF7 NF2
6	tuberculum sellae meningioma	10.3	TRAF7 NF2
7	sella turcica neoplasm	10.3	TRAF7 NF2
8	intraneural perineurioma	10.3	TRAF7 NF2
9	lung meningioma	10.2	PGR NF2
10	polyp of corpus uteri	10.2	PGR NF2
11	epidural spinal canal neoplasm	10.1	PAGE2 NF2
12	sphenoorbital meningioma	10.1	TRAF7 SMARCE1 NF2
13	cavernous sinus meningioma	10.1	TRAF7 SMARCE1 NF2
14	intraventricular meningioma	10.1	TRAF7 SMARCE1 NF2
15	endocrine pancreas disease	10.1	SSTR2 SST
16	carcinoid tumors, intestinal	10.1	SSTR2 SST
17	choroid plexus meningioma	10.1	HOXA6 DPYSL5
18	gastrointestinal neuroendocrine tumor	10.1	SSTR2 SST
19	pulmonary neuroendocrine tumor	10.1	SSTR2 SST
20	esophageal neuroendocrine tumor	10.1	SSTR2 SST
21	pancreatic endocrine carcinoma	10.1	SSTR2 SST
22	hormone producing pituitary cancer	10.1	SSTR2 SST
23	hyperpituitarism	10.1	SSTR2 SST
24	cerebellopontine angle meningioma	10.1	SMARCE1 NF2 DPYSL5
25	petroclival meningioma	10.0	TRAF7 PAGE2 NF2
26	somatostatinoma	10.0	SSTR2 SST
27	full schwannomatosis	10.0	SMARCB1 NF2
28	acth-secreting pituitary adenoma	10.0	SSTR2 SST
29	posterior pituitary gland neoplasm	10.0	SMARCB1 NF2
30	peripheral nerve schwannoma	10.0	SMARCB1 NF2
31	microcystic meningioma	10.0	TRAF7 SSTR2 SMARCE1 NF2
32	pineal region meningioma	10.0	SMARCB1 NF2
33	plexiform schwannoma	10.0	SMARCB1 NF2
34	schwannomatosis 1	10.0	SMARCB1 NF2
35	cerebellopontine angle tumor	10.0	SMARCB1 NF2
36	psammomatous meningioma	10.0	TRAF7 SSTR2 PGR NF2
37	cellular schwannoma	10.0	SMARCB1 NF2
38	atypical neurofibroma	10.0	SMARCB1 NF2
39	melanotic neurilemmoma	10.0	SMARCB1 NF2
40	schwannoma of twelfth cranial nerve	10.0	SMARCB1 NF2
41	carney complex variant	10.0	SST NF2 ARMC5
42	hypoglossal nerve disease	10.0	SMARCB1 NF2
43	spinal cord ependymoma	10.0	SMARCB1 NF2
44	anaplastic ependymoma	9.9	SMARCB1 NF2
45	brain cancer	9.9
46	multiple endocrine neoplasia, type i	9.9	SSTR2 SST ARMC5
47	functioning pituitary adenoma	9.9	SSTR2 SST
48	plexiform neurofibroma	9.9	SMARCB1 NF2
49	high grade ependymoma	9.9	SMARCB1 NF2
50	cerebral ventricle cancer	9.9	SMARCB1 NF2

Graphical network of the top 20 diseases related to Brain Meningioma:

Sources

Symptoms & Phenotypes for Brain Meningioma

UMLS symptoms related to Brain Meningioma:

headache; seizures

GenomeRNAi Phenotypes related to Brain Meningioma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased proliferation	GR00094-A	8.62	NF2 SMARCB1

Sources

Drugs & Therapeutics for Brain Meningioma

Drugs for Brain Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Everolimus

Approved

Phase 2

159351-69-6

70789204 6442177

2

Bevacizumab

Approved, Investigational

Phase 2

216974-75-3

135329020

3

Angiogenesis Inhibitors

Phase 2

4

Immunosuppressive Agents

Phase 2

5

Antineoplastic Agents, Immunological

Phase 2

6

Immunologic Factors

Phase 2

7

Ropivacaine

Approved

84057-95-4

71273 175805

8

Tranexamic acid

Approved

1197-18-8

5526

9

Coal tar

Approved

8007-45-2

10

Anesthetics, Local

11

Anesthetics

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma	Recruiting	NCT03180268	Phase 3
2	Phase II Trial of SMO/ AKT/ NF2/CDK Inhibitors in Progressive Meningiomas With SMO/ AKT/ NF2/CDK Pathway Mutations	Recruiting	NCT02523014	Phase 2	Vismodegib;FAK Inhibitor GSK2256098;Capivasertib;Abemaciclib
3	A Phase II Trial of the Combination of Bevacizumab and Everolimus in Patients With Refractory, Progressive Intracranial Meningioma	Terminated	NCT00972335	Phase 2	Everolimus;Bevacizumab
4	Hyperbaric Oxygen Therapy Can Improve Neurological State Post Meningioma Removal Surgery -Randomized Prospective Trial	Unknown status	NCT02084927	Phase 1
5	Effects of Preoperative Scalp Nerve Block on Postoperative Recovery Quality in Patients Undergoing Excision of Intracranial Meningioma	Completed	NCT03648034
6	Effect of Tranexamic Acid on Intraoperative Blood Loss in Patients Undergoing Brain Meningioma Resections: Study Protocol of a Randomised Controlled Trial	Recruiting	NCT05230381		Continous infusion;Single infusion;Placebo
7	Therapeutic Endovascular Embolization for Intracranial Meningioma	Recruiting	NCT05416567
8	Multisession Radiosurgery in Large Meningiomas	Active, not recruiting	NCT02974127
9	Spheno_orbital Meningioma Enplaque With Proptosis; Surgical Techniques and Outcomes	Not yet recruiting	NCT04710485

Search NIH Clinical Center for Brain Meningioma

Sources

Genetic Tests for Brain Meningioma

Sources

Anatomical Context for Brain Meningioma

Organs/tissues related to Brain Meningioma:

MalaCards : Brain, Spinal Cord, Temporal Lobe, Bone, Pituitary

Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Brain Meningioma:

#	Tissue Anatomical CompartmentCell	Relevance
1	Brain Anterior Dura Mater	Affected by disease

Sources

Publications for Brain Meningioma

Articles related to Brain Meningioma:

(show all 41)

#	Title	Authors	PMID	Year
1	Deep neural networks allow expert-level brain meningioma segmentation and present potential for improvement of clinical practice. ⁶²	Boaro A...Arnaout O	36104424	2022
2	Ceftazidime-avibactam and intrapleural amikacin therapy for extensively drug-resistant Pseudomonas aeruginosa thoracic empyema: A case report. ⁶²	Chen TT...Liu HY	35713457	2022
3	Medical thoracoscopy-diagnosed pleural angiosarcoma after complete resection of brain meningioma in an adolescent male. ⁶²	Ai L...Li Y	35181210	2022
4	Atypical Presentation of Transcranial Extension of Intracranial Meningiomas. ⁶²	Nahm WJ...Hinds B	35171886	2022
5	Outcomes of Preserving the Hypertrophic Arachnoid Membrane in the Brain-meningioma Interface: Long-term Follow-up. ⁶²	Nakasu Y...Hayashi N	34719581	2022
6	Sternal Metastasis of Brain Meningioma - A Case Report. ⁶²	Matsumura S...Adachi N	34281871	2021
7	Predicting meningioma consistency and brain-meningioma interface with intraoperative strain ultrasound elastography: a novel application to guide surgical strategy. ⁶²	Della Pepa GM...Olivi A	33386015	2021
8	Investigating Effective Factors on Estimated Hemorrhage Intraoperative in Brain Meningioma Surgery. ⁶²	Tabibkhooei A...Ebrahimnia F	33643556	2020
9	Total DNA methylation as a biomarker of DNA damage and tumor malignancy in intracranial meningiomas. ⁶²	Barciszewska AM	32493231	2020
10	Multiple Pulmonary and Pleural Metastases in Recurrent Intracranial Meningioma with Genetic Changes: Case Report and Review of the Literature. ⁶²	He N...Lei K	31954911	2020
11	Microscopic brain invasion in meningiomas previously classified as WHO grade I is not associated with patient outcome. ⁶²	Biczok A...Schichor C	31713016	2019
12	LGR5 and Downstream Intracellular Signaling Proteins Play Critical Roles in the Cell Proliferation of Neuroblastoma, Meningioma and Pituitary Adenoma. ⁶²	Hwang M...Koh SH	31698554	2019
13	Dosimetric comparison of conformal technique (3D) with volumetric modulated arc therapy with respect to doses obtained in the temporal lobe area in patients irradiated for brain meningioma. ⁶²	Trembecki L...Maciejczyk A	31193916	2019
14	Prevalence of hitherto unknown brain meningioma detected on 68Ga-DOTATATE positron-emission tomography/computed tomography in patients with metastatic neuroendocrine tumor and exploring potential of 177Lu-DOTATATE peptide receptor radionuclide therapy as single-shot treatment approach targeting both tumors. ⁶²	Parghane RV...Basu S	31040748	2019
15	The Sovereignty of Primary Cranial Tumors-Meningiomas: Vetting the Cardinal Epidemiological Features. ⁶²	Rami A...Amer AS	30814776	2018
16	Nanoparticle-enabled experimentally trained wavelet-domain denoising method for optical coherence tomography. ⁶²	Dolganova IN...Zaytsev KI	29644811	2018
17	Role of Caspase-9 Gene Ex5+32 G>A (rs1052576) Variant in Susceptibility to Primary Brain Tumors. ⁶²	Ozdogan S...Isbir T	28870924	2017
18	Radiologic and histologic features of the T2 hyperintensity rim of meningiomas on magnetic resonance images. ⁶²	Uchida H...Arita K	28059671	2017
19	Ideomotor Apraxia Due to Injury of the Superior Longitudinal Fasciculus. ⁶²	Jang SH...Jang WH	27003199	2016
20	Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery. ⁶²	Spinelli AE...Boschi F	27156713	2016
21	Rare giant bilateral calvarial hyperostosis across the superior sagittal sinus secondary to brain meningioma: A case report. ⁶²	Zhang H...Zhang X	24959261	2014
22	Vertebral metastases from intracranial meningioma. ⁶²	Zaghouani H...Kraiem C	25298865	2014
23	Surgical resection of twenty-three cases of brain meningioma. ⁶²	Ijiri A...Nakade T	24200893	2014
24	Carotid artery stenting in patients with brain meningioma. ⁶²	Mirabella D...Bajardi G	24791910	2014
25	Brain meningioma with initial manifestation similar to cervical radiculopathy: a case report. ⁶²	Huang YH...Chou LW	25028552	2014
26	Brain meningioma in a patient with complaints of low back pain and leg weakness. ⁶²	Pottkotter K...Di Stasi S	23126500	2013
27	Brain meningioma invading and destructing the skull bone: replacement of the missing bone in vivo. ⁶²	Velnar T...Limbaeck-Stokin C	22933971	2011
28	Nervous system tumors in adult immigrants to Sweden by subsite and histology. ⁶²	Mousavi SM...Hemminki K	21175998	2011
29	[Clinical application of the plasma substitutes in patients with postoperative complications after surgeries for brain meningioma]. ⁶²	Kvasha MS...Pushkareva TM	21698934	2011
30	Brain surface motion imaging to predict adhesions between meningiomas and the brain surface. ⁶²	Taoka T...Kichikawa K	20333508	2010
31	Extraneural metastases from cranial meningioma: a case report. ⁶²	Abboud M...Geara FB	19580667	2009
32	[What is your diagnosis? Extradural brain meningioma with rhabdoid features]. ⁶²		16382986	2005
33	Microscopic anatomy of the brain-meningioma interface. ⁶²	Nakasu S...Matsuda M	18095106	2005
34	[Combined approach to the treatment of severe aortic stenosis and to three coronary vessel diseases in patients with brain meningioma and severe stenosis of internal carotid artery]. ⁶²	Simek M...Plesnikova Y	16335703	2005
35	Evaluation of the tumor-brain interface of intracranial meningiomas on MR imaging including FLAIR images. ⁶²	Takeguchi T...Ohnishi T	16222110	2003
36	Stereotactic radiosurgery for meningiomas. ⁶²	Chin LS...Regine WF	15669817	2003
37	[Significance of the unbalanced expression of Th1/Th2 type cytokines in human glioma]. ⁶²	Hu YS...Sun R	12901105	2001
38	Analysis of chromosome 22 loci in meningioma. Alterations in the leukemia inhibitory factor (LIF) locus. ⁶²	Pergolizzi RG...Erster SH	7916188	1994
39	[Diagnosis of cerebral meningioma before hospitalization]. ⁶²	Kamalova GM	7785249	1994
40	Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors. ⁶²	Rao JS...Sawaya R	8485704	1993
41	The occurrence of polyunsaturated aldehydes in choline-containing phosphoglycerides of a human brain meningioma. ⁶²	Bell OE...White HB	6064623	1967

Sources

Genes for Brain Meningioma

Genes related to Brain Meningioma (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	NF2	NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor	Protein Coding	6.43	DISEASES inferred ¹⁴
2	TRAF7	TNF Receptor Associated Factor 7	Protein Coding	5.21	DISEASES inferred ¹⁴
3	SSTR2	Somatostatin Receptor 2	Protein Coding	4.79	DISEASES inferred ¹⁴
4	SH2D2A	SH2 Domain Containing 2A	Protein Coding	4.51	DISEASES inferred ¹⁴
5	SMARCE1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily E, Member 1	Protein Coding	4.42	DISEASES inferred ¹⁴
6	PGR	Progesterone Receptor	Protein Coding	4.37	DISEASES inferred ¹⁴
7	ARMC5	Armadillo Repeat Containing 5	Protein Coding	4.37	DISEASES inferred ¹⁴
8	DPYSL5	Dihydropyrimidinase Like 5	Protein Coding	4.34	DISEASES inferred ¹⁴
9	HOXA6	Homeobox A6	Protein Coding	4.33	DISEASES inferred ¹⁴
10	PAGE2	PAGE Family Member 2	Protein Coding	4.28	DISEASES inferred ¹⁴
11	SMO	Smoothened, Frizzled Class Receptor	Protein Coding	4.27	DISEASES inferred ¹⁴
12	SMARCB1	SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1	Protein Coding	4.27	DISEASES inferred ¹⁴
13	SST	Somatostatin	Protein Coding	4.16	DISEASES inferred ¹⁴

Sources

Variations for Brain Meningioma

Sources

Expression for Brain Meningioma

Search GEO for disease gene expression data for Brain Meningioma.

Sources

Pathways for Brain Meningioma

Pathways related to Brain Meningioma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known ⁶⁶	10.74	SMARCE1 SMARCB1
2	Tumor suppressor activity of SMARCB1 ⁷⁴ Show member pathways GLI proteins bind promoters of Hh responsive genes to promote transcription ⁶⁶	10.33	SMO SMARCE1 SMARCB1
3	Validated nuclear estrogen receptor beta network ⁶¹	10.13	SMARCE1 SMARCB1

Sources

GO Terms for Brain Meningioma

Cellular components related to Brain Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nBAF complex	GO:0071565	9.62	SMARCE1 SMARCB1
2	RSC-type complex	GO:0016586	9.56	SMARCE1 SMARCB1
3	npBAF complex	GO:0071564	9.46	SMARCE1 SMARCB1
4	brahma complex	GO:0035060	9.26	SMARCE1 SMARCB1
5	bBAF complex	GO:0140092	8.92	SMARCE1 SMARCB1

Biological processes related to Brain Meningioma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	nucleosome disassembly	GO:0006337	9.26	SMARCE1 SMARCB1
2	positive regulation of cell differentiation	GO:0045597	9.1	SMARCE1 SMARCB1 NF2

Sources

Sources for Brain Meningioma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: BRN034 MIFTS: 32	Brain Meningioma Categories: Cancer diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables