MCID: BRN034
MIFTS: 33

Brain Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Meningioma

MalaCards integrated aliases for Brain Meningioma:

Name: Brain Meningioma 12 15
Intracranial Meningioma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060106
UMLS 70 C0349604

Summaries for Brain Meningioma

Disease Ontology : 12 A brain cancer that is characterized by tumor of the meninges, that develops from the membranes that surround the brain and spinal cord, has material basis in abnormally proliferating cells derives from meningeal cells of embryonic ectoderm origin.

MalaCards based summary : Brain Meningioma, also known as intracranial meningioma, is related to secretory meningioma and meningioma, familial, and has symptoms including seizures and headache. An important gene associated with Brain Meningioma is NF2 (Neurofibromin 2). The drugs Everolimus and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include Brain, spinal cord and breast, and related phenotypes are Increased ionizing radiation sensitivity and mortality/aging

Related Diseases for Brain Meningioma

Diseases related to Brain Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 secretory meningioma 30.7 TRAF7 NF2
2 meningioma, familial 30.0 TRAF7 PGR NF2
3 benign meningioma 29.8 TRAF7 PGR NF2
4 childhood brain meningioma 11.4
5 intracranial meningioma 10.4
6 lymphoplasmacyte-rich meningioma 10.4
7 pediatric meningioma 10.2 TRAF7 NF2
8 psammomatous meningioma 10.2 TRAF7 NF2
9 meninges hemangiopericytoma 10.2 TRAF7 NF2
10 angiomatous meningioma 10.2 TRAF7 NF2
11 cerebellopontine angle tumor 10.2 NF2 HEYL
12 intraneural perineurioma 10.2 TRAF7 NF2
13 frontal convexity meningioma 10.2 TRAF7 NF2
14 chordoid meningioma 10.2 TRAF7 NF2
15 lung meningioma 10.1 PGR NF2
16 rhabdoid meningioma 10.1 TRAF7 NF2
17 polyp of corpus uteri 10.1 PGR NF2
18 fibrous meningioma 10.1 TRAF7 NF2
19 cerebellopontine angle meningioma 10.1 HEYL AMPH
20 skull base meningioma 10.1 TRAF7 SMO NF2
21 chordoid glioma 10.1 PGR NF2
22 meningioma, radiation-induced 10.1 TRAF7 SMO NF2
23 peritoneal mesothelioma 10.0 PGR NF2
24 olfactory groove meningioma 10.0 TRAF7 PGR NF2
25 lateral ventricle meningioma 10.0 WDR74 NSA2
26 anterior cranial fossa meningioma 10.0 TRAF7 PGR NF2
27 transitional meningioma 10.0 TRAF7 PGR NF2
28 meningothelial meningioma 10.0 TRAF7 PGR NF2
29 spinal canal and spinal cord meningioma 10.0 TRAF7 PGR NF2
30 spinal meningioma 10.0 TRAF7 PGR NF2
31 clear cell meningioma 10.0 TRAF7 PGR NF2
32 cerebral meningioma 9.9 PGR LIFR
33 spinal cord disease 9.9 NF2 AMPH
34 skull base cancer 9.8 TRAF7 SMO PGR NF2
35 robinow syndrome, autosomal dominant 1 9.8 WDR74 NSA2
36 calvarial hyperostosis 9.8
37 carotid stenosis 9.8
38 neuroendocrine tumor 9.8
39 hyperostosis 9.8
40 radiculopathy 9.8
41 back pain 9.8
42 intraventricular meningioma 9.7 WDR74 TRAF7 NSA2 NF2

Graphical network of the top 20 diseases related to Brain Meningioma:



Diseases related to Brain Meningioma

Symptoms & Phenotypes for Brain Meningioma

UMLS symptoms related to Brain Meningioma:


seizures; headache

GenomeRNAi Phenotypes related to Brain Meningioma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased ionizing radiation sensitivity GR00232-A-1 8.62 NSA2 SMO

MGI Mouse Phenotypes related to Brain Meningioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.28 AMPH HEYL LIFR NF2 NSA2 PGR

Drugs & Therapeutics for Brain Meningioma

Drugs for Brain Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3
3 Angiogenesis Inhibitors Phase 2
4 Antineoplastic Agents, Immunological Phase 2
5 Immunosuppressive Agents Phase 2
6 Immunologic Factors Phase 2
7
Ropivacaine Approved 84057-95-4 71273 175805
8 Anesthetics
9 Anesthetics, Local

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Observation Versus Conventional-Fractionated Radiotherapy or Radiosurgery After Non-radical Surgery for Benign Intracranial Meningiomas: A Phase III Study Terminated NCT00104936 Phase 3
2 Phase II Trial of SMO/AKT/NF2 Inhibitors in Progressive Meningiomas With SMO/AKT/NF2 Mutations Suspended NCT02523014 Phase 2 vismodegib;GSK2256098
3 A Phase II Trial of the Combination of Bevacizumab and Everolimus in Patients With Refractory, Progressive Intracranial Meningioma Terminated NCT00972335 Phase 2 Everolimus;Bevacizumab
4 Hyperbaric Oxygen Therapy Can Improve Neurological State Post Meningioma Removal Surgery -Randomized Prospective Trial Unknown status NCT02084927 Phase 1
5 Effects of Preoperative Scalp Nerve Block on Postoperative Recovery Quality in Patients Undergoing Excision of Intracranial Meningioma Completed NCT03648034
6 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127
7 Spheno_orbital Meningioma Enplaque With Proptosis; Surgical Techniques and Outcomes Not yet recruiting NCT04710485

Search NIH Clinical Center for Brain Meningioma

Genetic Tests for Brain Meningioma

Anatomical Context for Brain Meningioma

MalaCards organs/tissues related to Brain Meningioma:

40
Brain, Spinal Cord, Breast, Pituitary, Endothelial, Colon, Lung
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Brain Meningioma:
# Tissue Anatomical CompartmentCell Relevance
1 Brain Anterior Dura Mater Affected by disease

Publications for Brain Meningioma

Articles related to Brain Meningioma:

(show top 50) (show all 875)
# Title Authors PMID Year
1
Effect of Surgeon Experience on Surgical Outcome of 80-Year-Old or Older Intracranial Meningioma Patients. 61
33422717 2021
2
Trends in the Management Paradigms of Intracranial Meningioma. 61
33777636 2021
3
Postpartum Recovery From Meningioma-Related Oculomotor Palsy. 61
33706360 2021
4
Clinical Outcome and Recurrence After Meningioma Surgery: An Experience from a Developing Country, Nepal. 61
33359878 2021
5
Value of KI-67/MIB-1 labeling index and simpson grading system to predict the recurrence of who grade I intracranial meningiomas compared to who grade II. 61
33775343 2021
6
Impact of meningioma surgery on use of antiepileptic, antidepressant, and sedative drugs: A Swedish nationwide matched cohort study. 61
33773085 2021
7
Efficacy of endovascular intratumoral embolization for meningioma: assessment using dynamic susceptibility contrast-enhanced perfusion-weighted imaging. 61
33722964 2021
8
Incidence and type of brain herniation associated with intracranial meningioma in dogs and cats. 61
33342961 2021
9
Meningioma MRI radiomics and machine learning: systematic review, quality score assessment, and meta-analysis. 61
33649882 2021
10
Study on intracranial meningioma using PET ligand investigation during follow-up over years (SIMPLIFY). 61
33694025 2021
11
Meningiomas and cyproterone acetate: a retrospective, monocentric cohort of 388 patients treated by surgery or radiotherapy for intracranial meningioma. 61
33392938 2021
12
Nation-wide Brain Tumor Registry-based Study of Intracranial Meningioma in Japan: Analysis of Surgery-related Risks. 61
33361655 2021
13
Subcutaneous seeding following surgical excision of an intracranial meningioma in a cat. 61
33588467 2021
14
Use of high dose cyproterone acetate and risk of intracranial meningioma in women: cohort study. 61
33536184 2021
15
Neurosurgery for intracranial meningioma in patients aged more than 80 years: benefits and rationale. 61
33470146 2021
16
Prediction of Meningioma WHO Grade Using PET Findings: A Systematic Review and Meta-Analysis. 61
33135239 2021
17
Management strategies and clinical follow-up of pregnant women with intracranial meningioma. 61
33767778 2021
18
Determinants and predictors for the long-term disease burden of intracranial meningioma patients. 61
33073326 2021
19
Predicting meningioma consistency and brain-meningioma interface with intraoperative strain ultrasound elastography: a novel application to guide surgical strategy. 61
33386015 2021
20
Long-Term Disease Burden and Survivorship Issues After Surgery and Radiotherapy of Intracranial Meningioma Patients. 61
32818258 2020
21
Surgical treatment of rostrotentorial meningioma complicated by foraminal herniation in the cat. 61
32478635 2020
22
ACKT: A Proposal for a Novel Score to Predict Prolonged Mechanical Ventilation after Surgical Treatment of Meningioma in Geriatric Patients. 61
33396290 2020
23
The Outcome of Intracranial Meningioma Surgery in Octogenarians: Matched Cohort Study. 61
32916350 2020
24
Mapping angiography and transarterial technetium macroaggregated albumin particle simulation of recurrent atypical intracranial meningioma: feasibility for potential vascular brachytherapy. 61
32983300 2020
25
A Grade I Intracranial Meningioma with Metastasis to Multiple Vertebral Bodies: A Case Report and Literature Review. 61
33329973 2020
26
Image-Guided Multisession Radiosurgery of Skull Base Meningiomas. 61
33260363 2020
27
Breast carcinoma metastasis in a resected meningioma with early diagnosis of oligometastatic disease: a case report. 61
33161726 2020
28
Stereotactic Radiosurgery for Intracranial Noncavernous Sinus Benign Meningioma: International Stereotactic Radiosurgery Society Systematic Review, Meta-Analysis and Practice Guideline. 61
32463867 2020
29
Metastasis of pulmonary adenocarcinoma to right occipital parafalcine meningioma: A case report and literature review. 61
33126391 2020
30
Treatment of intracranial meningioma with single-session and fractionated radiosurgery: a propensity score matching study. 61
33116194 2020
31
Frailty predicts worse outcomes after intracranial meningioma surgery irrespective of existing prognostic factors. 61
33002880 2020
32
Use of MRI increases interobserver agreement on gross tumor volume for imaging-diagnosed canine intracranial meningioma. 61
33090601 2020
33
Prognostic value of the Simpson grading scale in modern meningioma surgery: Barrow Neurological Institute experience. 61
33096534 2020
34
Intracranial meningioma and concomitant cavernous malformation: A series description and review of the literature. 61
32861039 2020
35
Estrogen hormone replacement therapy in incidental intracranial meningioma: a growth-rate analysis. 61
33087798 2020
36
Risk factors for preoperative seizures in intracranial meningiomas. 61
33056948 2020
37
Intracranial Meningiomas in the Elderly: Clinical, Surgical and Economic Evaluation. A Multicentric Experience. 61
32962243 2020
38
Pre-surgical embolization of intracranial meningioma with Onyx: A safety and efficacy study. 61
31229578 2020
39
Location and Diameter of Intracranial Meningioma as Predictors of Peritumoral Brain Oedema and Mass Effect. 61
32423785 2020
40
The effect of socioeconomic status on age at diagnosis and overall survival in patients with intracranial meningioma. 61
32878534 2020
41
Response assessment of somatostatin receptor targeted radioligand therapies for progressive intracranial meningioma. 61
32691404 2020
42
Investigating Effective Factors on Estimated Hemorrhage Intraoperative in Brain Meningioma Surgery. 61
33643556 2020
43
Augmented reality in intracranial meningioma surgery: report of a case and systematic review. 61
32347678 2020
44
The Ki-67 Proliferation Index as a Marker of Time to Recurrence in Intracranial Meningioma. 61
32614441 2020
45
Socioeconomic burden and quality of life in meningioma patients. 61
32128657 2020
46
Central retinal artery occlusion combined with posterior ciliary artery occlusion after preoperative embolization of the middle meningeal artery for intracranial meningioma: A case report. 61
32664165 2020
47
Risk of tumor recurrence in intracranial meningiomas: comparative analyses of the predictive value of the postoperative tumor volume and the Simpson classification. 61
32679565 2020
48
Total DNA methylation as a biomarker of DNA damage and tumor malignancy in intracranial meningiomas. 61
32493231 2020
49
Treatment Outcomes of Incidental Intracranial Meningiomas: Results from the IMPACT Cohort. 61
32200011 2020
50
Differentiation of intracranial meningioma from dural metastasis with somatostatin receptor scintigraphy: An underutilised solution to a common problem. 61
31995193 2020

Variations for Brain Meningioma

Expression for Brain Meningioma

Search GEO for disease gene expression data for Brain Meningioma.

Pathways for Brain Meningioma

GO Terms for Brain Meningioma

Cellular components related to Brain Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 preribosome, large subunit precursor GO:0030687 8.62 WDR74 NSA2

Biological processes related to Brain Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.33 SMO PGR HEYL
2 odontogenesis of dentin-containing tooth GO:0042475 8.96 SMO NF2
3 regulation of neurogenesis GO:0050767 8.62 NF2 HEYL

Sources for Brain Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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