MCID: BRN034
MIFTS: 29

Brain Meningioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Brain Meningioma

MalaCards integrated aliases for Brain Meningioma:

Name: Brain Meningioma 38 12 15
Intracranial Meningioma 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060106
UMLS 73 C0349604

Summaries for Brain Meningioma

Disease Ontology : 12 A brain cancer that is characterized by tumor of the meninges, that develops from the membranes that surround the brain and spinal cord, has material basis in abnormally proliferating cells derives from meningeal cells of embryonic ectoderm origin.

MalaCards based summary : Brain Meningioma, also known as intracranial meningioma, is related to childhood brain meningioma and ischemia, and has symptoms including seizures and headache. An important gene associated with Brain Meningioma is CASP9 (Caspase 9). The drugs Pasireotide and Everolimus have been mentioned in the context of this disorder. Affiliated tissues include Brain, brain and spinal cord.

Related Diseases for Brain Meningioma

Diseases related to Brain Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 childhood brain meningioma 12.4
2 ischemia 9.8 CASP9 GFAP
3 medulloblastoma 9.8 CASP9 GFAP
4 ewing sarcoma 9.8 CASP9 GFAP
5 calvarial hyperostosis 9.7
6 hyperostosis 9.7
7 radiculopathy 9.7
8 alzheimer disease 9.7 CASP9 GFAP

Graphical network of the top 20 diseases related to Brain Meningioma:



Diseases related to Brain Meningioma

Symptoms & Phenotypes for Brain Meningioma

UMLS symptoms related to Brain Meningioma:


seizures, headache

Drugs & Therapeutics for Brain Meningioma

Drugs for Brain Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 31)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pasireotide Approved Phase 2 396091-73-9 9941444
2
Everolimus Approved Phase 2 159351-69-6 6442177
3
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
4
Sirolimus Approved, Investigational Phase 2 53123-88-9 46835353 6436030 5284616
5
Bevacizumab Approved, Investigational Phase 2 216974-75-3
6
Somatostatin Approved, Investigational Phase 2 51110-01-1, 38916-34-6 53481605
7 Hormones Phase 2
8 Hormone Antagonists Phase 2
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
10 Immunologic Factors Phase 2,Phase 1
11 Antifungal Agents Phase 2
12 Antibiotics, Antitubercular Phase 2
13 Anti-Infective Agents Phase 2
14 Immunosuppressive Agents Phase 2
15 Angiogenesis Inhibitors Phase 2
16 Angiogenesis Modulating Agents Phase 2
17 Anti-Bacterial Agents Phase 2
18
Cobalt Approved, Experimental Phase 1 7440-48-4 104729
19 Antibodies Phase 1
20 Antibodies, Monoclonal Phase 1
21 Immunoglobulins Phase 1
22
Heparin Approved, Investigational 9005-49-6 772 46507594
23
Dalteparin Approved 9005-49-6
24
Enoxaparin Approved 9005-49-6 772
25
Ropivacaine Approved Not Applicable 84057-95-4 175805 71273
26 calcium heparin
27 Heparin, Low-Molecular-Weight
28 Anesthetics Not Applicable
29 Anesthetics, Local Not Applicable
30 Central Nervous System Depressants Not Applicable
31 Peripheral Nervous System Agents Not Applicable

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery Recruiting NCT03180268 Phase 3
2 Radiotherapy or Radiosurgery Compared With Observation Alone in Treating Patients With Newly Diagnosed, Benign Meningioma That Has Been Partially Removed by Surgery Terminated NCT00104936 Phase 3
3 Monthly SOM230C for Recurrent or Progressive Meningioma Completed NCT00859040 Phase 2 SOM230C
4 Vismodegib and FAK Inhibitor GSK2256098 in Treating Patients With Progressive Meningiomas Suspended NCT02523014 Phase 2 vismodegib;GSK2256098
5 Trial of the Combination of Bevacizumab and Everolimus in Patients With Refractory, Progressive Intracranial Meningioma Terminated NCT00972335 Phase 2 Everolimus;Bevacizumab
6 Phase II Study of SOM230 in Patients With Recurrent or Progressive Meningioma Terminated NCT00813592 Phase 2 SOM230B
7 Hyperbaric Oxygen Therapy Can Improve Neurological State Post Meningioma Removal Surgery Unknown status NCT02084927 Phase 1
8 Neoadjuvant Avelumab and Hypofractionated Proton Radiation Therapy Followed by Surgery for Recurrent Radiation-refractory Meningioma Recruiting NCT03267836 Phase 1 Avelumab
9 A Comparative Study of Prophylactic Anticoagulation in Meningioma Surgery Completed NCT01941602 prophylactic enoxaparin
10 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
11 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127
12 Effects of Scalp Nerve Block With Ropivacaine on Postoperative Recovery Quality Not yet recruiting NCT03648034 Not Applicable

Search NIH Clinical Center for Brain Meningioma

Genetic Tests for Brain Meningioma

Anatomical Context for Brain Meningioma

MalaCards organs/tissues related to Brain Meningioma:

41
Brain, Spinal Cord, Bone, Lung, Pituitary, Prostate, Heart
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Brain Meningioma:
# Tissue Anatomical CompartmentCell Relevance
1 Brain Anterior Dura Mater Affected by disease

Publications for Brain Meningioma

Articles related to Brain Meningioma:

(show top 50) (show all 264)
# Title Authors Year
1
Intracranial Meningioma Surgery: Value-Based Care Determinants in New York State, 1995-2015. ( 30010072 )
2018
2
Surgical outcome in elderly patients with intracranial meningioma. ( 30031568 )
2018
3
High-Frequency Irreversible Electroporation for Intracranial Meningioma: A Feasibility Study in a Spontaneous Canine Tumor Model. ( 30071778 )
2018
4
Is the Simpson Grading System Applicable to Estimate the Risk of Tumor Progression After Microsurgery for Recurrent Intracranial Meningioma? ( 30081236 )
2018
5
Iatrogenic subcutaneous metastasis from WHO Grade I intracranial meningioma. ( 30253907 )
2018
6
Intracranial meningioma: Experience with stereotactic radiotherapy. ( 30358227 )
2018
7
Preoperative grading of intracranial meningioma by magnetic resonance spectroscopy (1H-MRS). ( 30452483 )
2018
8
Atypical Intracranial Meningioma with Metastasis to C-7 Vertebral Body: A Case Report. ( 30465962 )
2018
9
Predictive factors of complications post intracranial meningioma surgery leading to early unplanned reoperations - a single center study. ( 30467430 )
2018
10
Treatment of grade II-III intracranial meningioma with helical tomotherapy. ( 30528356 )
2018
11
Single-Fractionated Stereotactic Radiosurgery for Intracranial Meningioma in Elderly Patients: 25-Year Experience at a Single Institution. ( 29554374 )
2018
12
Intracranial meningioma with carcinoma tumor-to-tumor metastasis: two case reports. ( 29698064 )
2018
13
Intracranial meningioma as primary presentation for an undiagnosed collision metastatic breast cancer: Case report and literature review. ( 29725531 )
2018
14
Evaluation of particle radiotherapy for the re-irradiation of recurrent intracranial meningioma. ( 29739417 )
2018
15
Outcome of elderly patients undergoing intracranial meningioma resection: a single center experience. ( 29808631 )
2018
16
National care among patients with WHO grade I intracranial meningioma. ( 29910033 )
2018
17
Widespread disseminated osseous metastases of intracranial meningioma with over 27-year-survivorship: a unique, idiosyncratic case. ( 29948769 )
2018
18
Multiple extraneural metastases from a benign intracranial meningioma. ( 29323008 )
2018
19
Long-term control and predictors of seizures in intracranial meningioma surgery: a population-based study. ( 29327143 )
2018
20
Surgery in elderly patients with intracranial meningioma: neuropsychological functioning during a long term follow-up. ( 29330748 )
2018
21
Isolated Extracranial Intraosseous Metastasis of an Intracranial Meningioma following Bevacizumab Therapy: Case Report and Review of the Literature. ( 29492134 )
2018
22
Surgical treatment and outcome in patients over 80 years old with intracranial meningioma. ( 29518711 )
2018
23
Sudden Unexpected Deaths Due to Intracranial Meningioma: Presentation of Six Fatal Cases, Review of the Literature, and A Discussion of the Mechanisms of Death. ( 28834541 )
2018
24
Quality of life after surgery for intracranial meningioma. ( 28902404 )
2018
25
Heterotopic Cutaneous Meningioma: An Unusual Presentation Occurring in a Patient With a Remote History of Intracranial Meningioma. ( 28984696 )
2018
26
Surgical Management of Giant Intracranial Meningioma: Operative Nuances, Challenges, and Outcome. ( 28987827 )
2018
27
Intracranial Meningioma in Patients Age <35 Years: Evolution of the Disease in the Era of Human Immunodeficiency Virus Infection. ( 28987830 )
2018
28
Near-infrared fluorescent image-guided surgery for intracranial meningioma. ( 28387632 )
2018
29
Retrospective Analysis of 449 Intracranial Meningioma Patients Operated Between 2007 and 2013 at a Single Institute. ( 27593846 )
2018
30
Donor-Cell Origin High-Risk Myelodysplastic Syndrome Synchronous with an Intracranial Meningioma-Like Tumor, 8 Years after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia. ( 28839454 )
2017
31
Evaluation of Ventriculoperitoneal Shunt-Related Complications in Intracranial Meningioma with Hydrocephalus. ( 28180040 )
2017
32
Fluorescein Sodium in Intracranial Meningioma Surgery. ( 29179415 )
2017
33
In Reply to the Letter to the Editor "Fluorescein Sodium in Intracranial Meningioma Surgery". ( 29179416 )
2017
34
Recurred Intracranial Meningioma: A Retrospective Analysis for Treatment Outcome and Prognostic Factor. ( 29188205 )
2017
35
Successful embolisation of an intracranial meningioma via a right-sided aortic arch. ( 29269362 )
2017
36
Development of a giant cornu cutaneum in a patient with a coincidental foreknown intracranial meningioma. ( 29368323 )
2017
37
Long-Term Volume Reduction Effects of Endovascular Embolization for Intracranial Meningioma: Preliminary Experience of 5 Cases. ( 28624563 )
2017
38
Stereotactic radiotherapy as primary definitive or postoperative treatment of intracranial meningioma of WHO grade II and III leads to better disease control than stereotactic radiotherapy of recurrent meningioma. ( 28667597 )
2017
39
Progression-Free Survival and Factors Associated with Postoperative Recurrence in 126 Patients with Atypical Intracranial Meningioma. ( 28838877 )
2017
40
Evaluation of acute normovolemic hemodilution in patients undergoing intracranial meningioma resection: A quasi-experimental trial. ( 28930850 )
2017
41
Rescue Measure in Giant Intracranial Meningioma Resection by Tranexamic Acid. ( 28936089 )
2017
42
Volumetric response of intracranial meningioma after photon or particle irradiation. ( 27911139 )
2017
43
Regression of intracranial meningioma following treatment with nivolumab: Case report and review of the literature. ( 28089420 )
2017
44
Assessment of intracranial meningioma-associated calcifications using susceptibility-weighted MRI. ( 28106942 )
2017
45
Effect of tranexamic acid on intraoperative blood loss and transfusion requirements in patients undergoing excision of intracranial meningioma. ( 28283245 )
2017
46
Application of Surgical Apgar Score in intracranial meningioma surgery. ( 28384177 )
2017
47
Simple Tumor Localization Scale for Estimating Management Outcome of Intracranial Meningioma. ( 28526644 )
2017
48
Close follow-up after discontinuation of cyproterone acetate: a possible option to defer surgery in patients with voluminous intracranial meningioma. ( 27857037 )
2017
49
Expansive Extracranial Growth of Intracranial Meningioma in Neurofibromatosis Type 2. ( 27272842 )
2016
50
Iatrogenic Seeding of Tumor Cells in Thigh Soft Tissue Upon Surgical Removal of Intracranial Meningioma. ( 27303610 )
2016

Variations for Brain Meningioma

Expression for Brain Meningioma

Search GEO for disease gene expression data for Brain Meningioma.

Pathways for Brain Meningioma

GO Terms for Brain Meningioma

Sources for Brain Meningioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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