MCID: BRN034
MIFTS: 32

Brain Meningioma

Categories: Cancer diseases, Neuronal diseases
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Aliases & Classifications for Brain Meningioma

MalaCards integrated aliases for Brain Meningioma:

Name: Brain Meningioma 11 14
Intracranial Meningioma 71

Classifications:



External Ids:

Disease Ontology 11 DOID:0060106
UMLS 71 C0349604

Summaries for Brain Meningioma

Disease Ontology: 11 A brain cancer that is characterized by tumor of the meninges, that develops from the membranes that surround the brain and spinal cord, has material basis in abnormally proliferating cells derives from meningeal cells of embryonic ectoderm origin.

MalaCards based summary: Brain Meningioma, also known as intracranial meningioma, is related to benign meningioma and intracranial meningioma, and has symptoms including headache and seizures. An important gene associated with Brain Meningioma is NF2 (NF2, Moesin-Ezrin-Radixin Like (MERLIN) Tumor Suppressor), and among its related pathways/superpathways are RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known and Tumor suppressor activity of SMARCB1. The drugs Everolimus and Bevacizumab have been mentioned in the context of this disorder. Affiliated tissues include Brain, spinal cord and temporal lobe, and related phenotype is Increased proliferation.

Related Diseases for Brain Meningioma

Diseases related to Brain Meningioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 benign meningioma 30.1 TRAF7 PGR NF2
2 intracranial meningioma 28.4 TRAF7 SSTR2 SST SMARCE1 SMARCB1 PGR
3 meningioma, familial 28.2 TRAF7 SSTR2 SST SMO SMARCE1 SMARCB1
4 childhood brain meningioma 11.4
5 foramen magnum meningioma 10.3 TRAF7 NF2
6 tuberculum sellae meningioma 10.3 TRAF7 NF2
7 sella turcica neoplasm 10.3 TRAF7 NF2
8 intraneural perineurioma 10.3 TRAF7 NF2
9 lung meningioma 10.2 PGR NF2
10 polyp of corpus uteri 10.2 PGR NF2
11 epidural spinal canal neoplasm 10.1 PAGE2 NF2
12 sphenoorbital meningioma 10.1 TRAF7 SMARCE1 NF2
13 cavernous sinus meningioma 10.1 TRAF7 SMARCE1 NF2
14 intraventricular meningioma 10.1 TRAF7 SMARCE1 NF2
15 endocrine pancreas disease 10.1 SSTR2 SST
16 carcinoid tumors, intestinal 10.1 SSTR2 SST
17 choroid plexus meningioma 10.1 HOXA6 DPYSL5
18 gastrointestinal neuroendocrine tumor 10.1 SSTR2 SST
19 pulmonary neuroendocrine tumor 10.1 SSTR2 SST
20 esophageal neuroendocrine tumor 10.1 SSTR2 SST
21 pancreatic endocrine carcinoma 10.1 SSTR2 SST
22 hormone producing pituitary cancer 10.1 SSTR2 SST
23 hyperpituitarism 10.1 SSTR2 SST
24 cerebellopontine angle meningioma 10.1 SMARCE1 NF2 DPYSL5
25 petroclival meningioma 10.0 TRAF7 PAGE2 NF2
26 somatostatinoma 10.0 SSTR2 SST
27 full schwannomatosis 10.0 SMARCB1 NF2
28 acth-secreting pituitary adenoma 10.0 SSTR2 SST
29 posterior pituitary gland neoplasm 10.0 SMARCB1 NF2
30 peripheral nerve schwannoma 10.0 SMARCB1 NF2
31 microcystic meningioma 10.0 TRAF7 SSTR2 SMARCE1 NF2
32 pineal region meningioma 10.0 SMARCB1 NF2
33 plexiform schwannoma 10.0 SMARCB1 NF2
34 schwannomatosis 1 10.0 SMARCB1 NF2
35 cerebellopontine angle tumor 10.0 SMARCB1 NF2
36 psammomatous meningioma 10.0 TRAF7 SSTR2 PGR NF2
37 cellular schwannoma 10.0 SMARCB1 NF2
38 atypical neurofibroma 10.0 SMARCB1 NF2
39 melanotic neurilemmoma 10.0 SMARCB1 NF2
40 schwannoma of twelfth cranial nerve 10.0 SMARCB1 NF2
41 carney complex variant 10.0 SST NF2 ARMC5
42 hypoglossal nerve disease 10.0 SMARCB1 NF2
43 spinal cord ependymoma 10.0 SMARCB1 NF2
44 anaplastic ependymoma 9.9 SMARCB1 NF2
45 brain cancer 9.9
46 multiple endocrine neoplasia, type i 9.9 SSTR2 SST ARMC5
47 functioning pituitary adenoma 9.9 SSTR2 SST
48 plexiform neurofibroma 9.9 SMARCB1 NF2
49 high grade ependymoma 9.9 SMARCB1 NF2
50 cerebral ventricle cancer 9.9 SMARCB1 NF2

Graphical network of the top 20 diseases related to Brain Meningioma:



Diseases related to Brain Meningioma

Symptoms & Phenotypes for Brain Meningioma

UMLS symptoms related to Brain Meningioma:


headache; seizures

GenomeRNAi Phenotypes related to Brain Meningioma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

Drugs & Therapeutics for Brain Meningioma

Drugs for Brain Meningioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Everolimus Approved Phase 2 159351-69-6 70789204 6442177
2
Bevacizumab Approved, Investigational Phase 2 216974-75-3 135329020
3 Angiogenesis Inhibitors Phase 2
4 Immunosuppressive Agents Phase 2
5 Antineoplastic Agents, Immunological Phase 2
6 Immunologic Factors Phase 2
7
Ropivacaine Approved 84057-95-4 71273 175805
8
Tranexamic acid Approved 1197-18-8 5526
9
Coal tar Approved 8007-45-2
10 Anesthetics, Local
11 Anesthetics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma Recruiting NCT03180268 Phase 3
2 Phase II Trial of SMO/ AKT/ NF2/CDK Inhibitors in Progressive Meningiomas With SMO/ AKT/ NF2/CDK Pathway Mutations Recruiting NCT02523014 Phase 2 Vismodegib;FAK Inhibitor GSK2256098;Capivasertib;Abemaciclib
3 A Phase II Trial of the Combination of Bevacizumab and Everolimus in Patients With Refractory, Progressive Intracranial Meningioma Terminated NCT00972335 Phase 2 Everolimus;Bevacizumab
4 Hyperbaric Oxygen Therapy Can Improve Neurological State Post Meningioma Removal Surgery -Randomized Prospective Trial Unknown status NCT02084927 Phase 1
5 Effects of Preoperative Scalp Nerve Block on Postoperative Recovery Quality in Patients Undergoing Excision of Intracranial Meningioma Completed NCT03648034
6 Effect of Tranexamic Acid on Intraoperative Blood Loss in Patients Undergoing Brain Meningioma Resections: Study Protocol of a Randomised Controlled Trial Recruiting NCT05230381 Continous infusion;Single infusion;Placebo
7 Therapeutic Endovascular Embolization for Intracranial Meningioma Recruiting NCT05416567
8 Multisession Radiosurgery in Large Meningiomas Active, not recruiting NCT02974127
9 Spheno_orbital Meningioma Enplaque With Proptosis; Surgical Techniques and Outcomes Not yet recruiting NCT04710485

Search NIH Clinical Center for Brain Meningioma

Genetic Tests for Brain Meningioma

Anatomical Context for Brain Meningioma

Organs/tissues related to Brain Meningioma:

MalaCards : Brain, Spinal Cord, Temporal Lobe, Bone, Pituitary
LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Brain Meningioma:
# Tissue Anatomical CompartmentCell Relevance
1 Brain Anterior Dura Mater Affected by disease

Publications for Brain Meningioma

Articles related to Brain Meningioma:

(show all 41)
# Title Authors PMID Year
1
Deep neural networks allow expert-level brain meningioma segmentation and present potential for improvement of clinical practice. 62
36104424 2022
2
Ceftazidime-avibactam and intrapleural amikacin therapy for extensively drug-resistant Pseudomonas aeruginosa thoracic empyema: A case report. 62
35713457 2022
3
Medical thoracoscopy-diagnosed pleural angiosarcoma after complete resection of brain meningioma in an adolescent male. 62
35181210 2022
4
Atypical Presentation of Transcranial Extension of Intracranial Meningiomas. 62
35171886 2022
5
Outcomes of Preserving the Hypertrophic Arachnoid Membrane in the Brain-meningioma Interface: Long-term Follow-up. 62
34719581 2022
6
Sternal Metastasis of Brain Meningioma - A Case Report. 62
34281871 2021
7
Predicting meningioma consistency and brain-meningioma interface with intraoperative strain ultrasound elastography: a novel application to guide surgical strategy. 62
33386015 2021
8
Investigating Effective Factors on Estimated Hemorrhage Intraoperative in Brain Meningioma Surgery. 62
33643556 2020
9
Total DNA methylation as a biomarker of DNA damage and tumor malignancy in intracranial meningiomas. 62
32493231 2020
10
Multiple Pulmonary and Pleural Metastases in Recurrent Intracranial Meningioma with Genetic Changes: Case Report and Review of the Literature. 62
31954911 2020
11
Microscopic brain invasion in meningiomas previously classified as WHO grade I is not associated with patient outcome. 62
31713016 2019
12
LGR5 and Downstream Intracellular Signaling Proteins Play Critical Roles in the Cell Proliferation of Neuroblastoma, Meningioma and Pituitary Adenoma. 62
31698554 2019
13
Dosimetric comparison of conformal technique (3D) with volumetric modulated arc therapy with respect to doses obtained in the temporal lobe area in patients irradiated for brain meningioma. 62
31193916 2019
14
Prevalence of hitherto unknown brain meningioma detected on 68Ga-DOTATATE positron-emission tomography/computed tomography in patients with metastatic neuroendocrine tumor and exploring potential of 177Lu-DOTATATE peptide receptor radionuclide therapy as single-shot treatment approach targeting both tumors. 62
31040748 2019
15
The Sovereignty of Primary Cranial Tumors-Meningiomas: Vetting the Cardinal Epidemiological Features. 62
30814776 2018
16
Nanoparticle-enabled experimentally trained wavelet-domain denoising method for optical coherence tomography. 62
29644811 2018
17
Role of Caspase-9 Gene Ex5+32 G>A (rs1052576) Variant in Susceptibility to Primary Brain Tumors. 62
28870924 2017
18
Radiologic and histologic features of the T2 hyperintensity rim of meningiomas on magnetic resonance images. 62
28059671 2017
19
Ideomotor Apraxia Due to Injury of the Superior Longitudinal Fasciculus. 62
27003199 2016
20
Cerenkov and radioluminescence imaging of brain tumor specimens during neurosurgery. 62
27156713 2016
21
Rare giant bilateral calvarial hyperostosis across the superior sagittal sinus secondary to brain meningioma: A case report. 62
24959261 2014
22
Vertebral metastases from intracranial meningioma. 62
25298865 2014
23
Surgical resection of twenty-three cases of brain meningioma. 62
24200893 2014
24
Carotid artery stenting in patients with brain meningioma. 62
24791910 2014
25
Brain meningioma with initial manifestation similar to cervical radiculopathy: a case report. 62
25028552 2014
26
Brain meningioma in a patient with complaints of low back pain and leg weakness. 62
23126500 2013
27
Brain meningioma invading and destructing the skull bone: replacement of the missing bone in vivo. 62
22933971 2011
28
Nervous system tumors in adult immigrants to Sweden by subsite and histology. 62
21175998 2011
29
[Clinical application of the plasma substitutes in patients with postoperative complications after surgeries for brain meningioma]. 62
21698934 2011
30
Brain surface motion imaging to predict adhesions between meningiomas and the brain surface. 62
20333508 2010
31
Extraneural metastases from cranial meningioma: a case report. 62
19580667 2009
32
[What is your diagnosis? Extradural brain meningioma with rhabdoid features]. 62
16382986 2005
33
Microscopic anatomy of the brain-meningioma interface. 62
18095106 2005
34
[Combined approach to the treatment of severe aortic stenosis and to three coronary vessel diseases in patients with brain meningioma and severe stenosis of internal carotid artery]. 62
16335703 2005
35
Evaluation of the tumor-brain interface of intracranial meningiomas on MR imaging including FLAIR images. 62
16222110 2003
36
Stereotactic radiosurgery for meningiomas. 62
15669817 2003
37
[Significance of the unbalanced expression of Th1/Th2 type cytokines in human glioma]. 62
12901105 2001
38
Analysis of chromosome 22 loci in meningioma. Alterations in the leukemia inhibitory factor (LIF) locus. 62
7916188 1994
39
[Diagnosis of cerebral meningioma before hospitalization]. 62
7785249 1994
40
Elevated levels of M(r) 92,000 type IV collagenase in human brain tumors. 62
8485704 1993
41
The occurrence of polyunsaturated aldehydes in choline-containing phosphoglycerides of a human brain meningioma. 62
6064623 1967

Variations for Brain Meningioma

Expression for Brain Meningioma

Search GEO for disease gene expression data for Brain Meningioma.

Pathways for Brain Meningioma

GO Terms for Brain Meningioma

Cellular components related to Brain Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nBAF complex GO:0071565 9.62 SMARCE1 SMARCB1
2 RSC-type complex GO:0016586 9.56 SMARCE1 SMARCB1
3 npBAF complex GO:0071564 9.46 SMARCE1 SMARCB1
4 brahma complex GO:0035060 9.26 SMARCE1 SMARCB1
5 bBAF complex GO:0140092 8.92 SMARCE1 SMARCB1

Biological processes related to Brain Meningioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleosome disassembly GO:0006337 9.26 SMARCE1 SMARCB1
2 positive regulation of cell differentiation GO:0045597 9.1 SMARCE1 SMARCB1 NF2

Sources for Brain Meningioma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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